PGM5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Phosphoglucomutases (EC 5.2.2.2.), such as PGM5, are phosphotransferases involved in interconversion of glucose-1-phosphate and glucose-6-phosphate. PGM activity is essential in formation of carbohydrates from glucose-6-phosphate and in formation of glucose-6-phosphate from galactose and glycogen (Edwards et al., 1995 [PubMed 8586438]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)7.28858164
2cardiac myofibril assembly (GO:0055003)7.26912550
3negative regulation of potassium ion transmembrane transporter activity (GO:1901017)6.37926574
4myofibril assembly (GO:0030239)6.37470903
5actin-myosin filament sliding (GO:0033275)5.92153076
6muscle filament sliding (GO:0030049)5.92153076
7negative regulation of potassium ion transmembrane transport (GO:1901380)5.78437648
8cardiac muscle cell development (GO:0055013)5.69826709
9cardiac cell development (GO:0055006)5.53407892
10positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.27485886
11plasma membrane repair (GO:0001778)5.22925410
12cardiac muscle contraction (GO:0060048)5.14982215
13actomyosin structure organization (GO:0031032)5.13273870
14actin-mediated cell contraction (GO:0070252)5.08592991
15regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO5.06902284
16bundle of His cell to Purkinje myocyte communication (GO:0086069)5.00805071
17regulation of skeletal muscle contraction (GO:0014819)4.96091907
18heart trabecula formation (GO:0060347)4.74584099
19regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.70000333
20ventricular cardiac muscle cell action potential (GO:0086005)4.61692418
21ventricular cardiac muscle tissue morphogenesis (GO:0055010)4.54414803
22cardiac muscle tissue morphogenesis (GO:0055008)4.54409951
23regulation of relaxation of muscle (GO:1901077)4.39188412
24regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.38987036
25muscle tissue morphogenesis (GO:0060415)4.38388068
26regulation of actin filament-based movement (GO:1903115)4.38338684
27tricarboxylic acid cycle (GO:0006099)4.33806540
28cardiac muscle hypertrophy (GO:0003300)4.21602996
29regulation of sarcomere organization (GO:0060297)4.19939105
30cellular response to epinephrine stimulus (GO:0071872)4.12731072
31actin filament-based movement (GO:0030048)4.09672860
32carnitine shuttle (GO:0006853)4.07366748
33adult heart development (GO:0007512)4.05463663
34striated muscle hypertrophy (GO:0014897)4.01537832
35regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.99152001
36striated muscle contraction (GO:0006941)3.94538485
37negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.86276193
38response to epinephrine (GO:0071871)3.85250639
39regulation of cardioblast differentiation (GO:0051890)3.81936782
40extracellular matrix assembly (GO:0085029)3.80488012
41cell communication involved in cardiac conduction (GO:0086065)3.77750562
42regulation of the force of heart contraction (GO:0002026)3.73823678
43regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.73757914
44regulation of striated muscle contraction (GO:0006942)3.72609018
45cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.67512539
46regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.61706230
47fatty acid transmembrane transport (GO:1902001)3.60531490
48trabecula formation (GO:0060343)3.59341959
49muscle hypertrophy (GO:0014896)3.56053550
50relaxation of cardiac muscle (GO:0055119)3.54932332
51regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.52141813
52negative regulation of striated muscle cell apoptotic process (GO:0010664)3.50596499
53cGMP-mediated signaling (GO:0019934)3.44409207
54regulation of cell communication by electrical coupling (GO:0010649)3.43629437
55striated muscle adaptation (GO:0014888)3.41914801
56regulation of membrane repolarization (GO:0060306)3.34445173
57cardiac muscle cell proliferation (GO:0060038)3.31307336
58striated muscle cell development (GO:0055002)3.29051389
59relaxation of muscle (GO:0090075)3.27003392
60response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.26751192
61muscle contraction (GO:0006936)3.23622396
62cell migration involved in heart development (GO:0060973)3.22292012
63relaxation of smooth muscle (GO:0044557)3.20321668
64skeletal muscle contraction (GO:0003009)3.19492221
65sarcoplasmic reticulum calcium ion transport (GO:0070296)3.18006493
66cell communication by electrical coupling (GO:0010644)3.15325669
67creatine metabolic process (GO:0006600)3.12509729
68regulation of acyl-CoA biosynthetic process (GO:0050812)3.12193582
69regulation of ATPase activity (GO:0043462)3.12091496
70regulation of ATP catabolic process (GO:1903289)3.12091496
71cardiac chamber formation (GO:0003207)3.11744865
72cardiac muscle cell action potential involved in contraction (GO:0086002)3.10023405
73cardiac muscle cell action potential (GO:0086001)3.09501853
74heart process (GO:0003015)3.08598054
75heart contraction (GO:0060047)3.08598054
76muscle hypertrophy in response to stress (GO:0003299)3.07556430
77cardiac muscle adaptation (GO:0014887)3.07556430
78cardiac muscle hypertrophy in response to stress (GO:0014898)3.07556430
79regulation of cardiac muscle contraction (GO:0055117)3.06820039
80regulation of cardiac muscle cell contraction (GO:0086004)3.05475009
81muscle system process (GO:0003012)3.03613882
82positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.03486384
83regulation of heart rate (GO:0002027)3.02468850
84negative regulation of potassium ion transport (GO:0043267)3.01920155
85hypotonic response (GO:0006971)3.01451016
86desmosome organization (GO:0002934)3.00014043
872-oxoglutarate metabolic process (GO:0006103)2.99983841
88carnitine transmembrane transport (GO:1902603)2.98150992
89regulation of muscle contraction (GO:0006937)2.94637721
90cardiac ventricle formation (GO:0003211)2.94269587
91peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.93958801
92regulation of heart contraction (GO:0008016)2.91500878
93response to inactivity (GO:0014854)2.90872787
94epithelial cell-cell adhesion (GO:0090136)2.89089383
95muscle cell development (GO:0055001)2.88636532
96regulation of fatty acid oxidation (GO:0046320)2.87851314
97muscle adaptation (GO:0043500)2.87216005
98positive regulation of myotube differentiation (GO:0010831)2.86415433
99response to caffeine (GO:0031000)2.85563400
100neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.83388985
101endocardial cushion morphogenesis (GO:0003203)2.83333867
102negative regulation of myotube differentiation (GO:0010832)2.80319097
103cardiac conduction (GO:0061337)2.80259984
104negative regulation of protein localization to cell surface (GO:2000009)2.80179248
105ventricular cardiac muscle cell development (GO:0055015)2.79051650
106regulation of cofactor metabolic process (GO:0051193)2.78664503
107regulation of coenzyme metabolic process (GO:0051196)2.78664503
108outflow tract septum morphogenesis (GO:0003148)2.78158024
109positive regulation of heart contraction (GO:0045823)2.77639840
110muscle fiber development (GO:0048747)2.77495777
111fibroblast migration (GO:0010761)2.77100739
112mesenchyme morphogenesis (GO:0072132)2.75048726
113negative regulation of heart growth (GO:0061117)2.74307664
114negative regulation of cardiac muscle tissue growth (GO:0055022)2.74307664
115amino-acid betaine transport (GO:0015838)2.72673594
116carnitine transport (GO:0015879)2.72673594
117regulation of calcium ion transmembrane transport (GO:1903169)2.71604422
118regulation of calcium ion transmembrane transporter activity (GO:1901019)2.71604422
119regulation of muscle system process (GO:0090257)2.71507697
120glucocorticoid biosynthetic process (GO:0006704)2.70023045
121urinary tract smooth muscle contraction (GO:0014848)2.69440432
122growth hormone secretion (GO:0030252)2.66268230
123skeletal muscle adaptation (GO:0043501)2.64192943
124positive regulation of vascular permeability (GO:0043117)2.61041380
125skeletal muscle tissue development (GO:0007519)2.60627342
126positive regulation of cation channel activity (GO:2001259)2.54091070
127striated muscle atrophy (GO:0014891)2.53686260
128regulation of myoblast differentiation (GO:0045661)2.47854089
129positive regulation of heart rate (GO:0010460)2.45034328
130negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.44685149
131muscle cell fate commitment (GO:0042693)2.44669374

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.44830851
2EP300_21415370_ChIP-Seq_HL-1_Mouse3.95991464
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.68190413
4RARG_19884340_ChIP-ChIP_MEFs_Mouse2.93034046
5ESR1_20079471_ChIP-ChIP_T-47D_Human2.89427008
6TBX20_22328084_ChIP-Seq_HEART_Mouse2.89271830
7TBX20_22080862_ChIP-Seq_HEART_Mouse2.89271830
8BP1_19119308_ChIP-ChIP_Hs578T_Human2.68090496
9CLOCK_20551151_ChIP-Seq_293T_Human2.60503563
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.60356775
11EZH2_22144423_ChIP-Seq_EOC_Human2.47443389
12ESR2_21235772_ChIP-Seq_MCF-7_Human2.45120446
13ZNF263_19887448_ChIP-Seq_K562_Human2.39708430
14EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.36691543
15CDX2_19796622_ChIP-Seq_MESCs_Mouse2.34683515
16* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.33199080
17TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.33165873
18SMAD_19615063_ChIP-ChIP_OVARY_Human2.24619530
19CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.07183244
20TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.04575922
21MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.03939722
22GBX2_23144817_ChIP-Seq_PC3_Human2.03314204
23ESR1_21235772_ChIP-Seq_MCF-7_Human1.89754710
24PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.88602926
25* PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.87514406
26ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.84347244
27NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.70190522
28NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.68650405
29PPAR_26484153_Chip-Seq_NCI-H1993_Human1.67924517
30TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.56263029
31ISL1_27105846_Chip-Seq_CPCs_Mouse1.55882614
32ZNF217_24962896_ChIP-Seq_MCF-7_Human1.53802055
33RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.53475294
34WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.52497453
35SOX9_24532713_ChIP-Seq_HFSC_Mouse1.51745197
36CJUN_26792858_Chip-Seq_BT549_Human1.50309904
37TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.49068127
38GATA4_21415370_ChIP-Seq_HL-1_Mouse1.46057628
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43794373
40WT1_19549856_ChIP-ChIP_CCG9911_Human1.43304413
41* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.42419437
42FOXO3_23340844_ChIP-Seq_DLD1_Human1.41785201
43STAT6_21828071_ChIP-Seq_BEAS2B_Human1.40913696
44RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40728647
45ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.39657254
46KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.39009883
47FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.38921390
48AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.38217777
49SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.38074362
50RNF2_18974828_ChIP-Seq_MESCs_Mouse1.36665097
51EZH2_18974828_ChIP-Seq_MESCs_Mouse1.36665097
52KDM2B_26808549_Chip-Seq_SUP-B15_Human1.36371930
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.35896009
54* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.33428580
55CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.32084124
56RUNX1_27514584_Chip-Seq_MCF-7_Human1.31141264
57ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.31083532
58AHR_22903824_ChIP-Seq_MCF-7_Human1.30877174
59GATA2_21666600_ChIP-Seq_HMVEC_Human1.30231216
60SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.28102367
61SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.27648777
62RACK7_27058665_Chip-Seq_MCF-7_Human1.24018741
63PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.24017157
64ELK3_25401928_ChIP-Seq_HUVEC_Human1.23779260
65HIF1A_21447827_ChIP-Seq_MCF-7_Human1.22918253
66SMAD4_21799915_ChIP-Seq_A2780_Human1.22887231
67NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.22063104
68NRF2_20460467_ChIP-Seq_MEFs_Mouse1.22063104
69STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.21612978
70SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.20465187
71THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.20306916
72SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.18925567
73WT1_25993318_ChIP-Seq_PODOCYTE_Human1.18627130
74NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.18530749
75ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.18480923
76LXR_22158963_ChIP-Seq_LIVER_Mouse1.16701489
77SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16672150
78NFIB_24661679_ChIP-Seq_LUNG_Mouse1.16593085
79DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.15704370
80CTNNB1_20460455_ChIP-Seq_HCT116_Human1.13092434
81JARID2_20075857_ChIP-Seq_MESCs_Mouse1.10625623
82ARNT_22903824_ChIP-Seq_MCF-7_Human1.10268368
83Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.10065311
84FOXA2_19822575_ChIP-Seq_HepG2_Human1.09737002
85SOX2_20726797_ChIP-Seq_SW620_Human1.08404741
86NR3C1_23031785_ChIP-Seq_PC12_Mouse1.06963527
87GATA1_22025678_ChIP-Seq_K562_Human1.06536250
88SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.06496413
89SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.06496413
90GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06404133
91CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.02177053
92PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.02085441
93SOX2_27498859_Chip-Seq_STOMACH_Mouse1.01496188
94PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.01169225
95* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.99797133
96SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.99586901
97ATF3_27146783_Chip-Seq_COLON_Human0.99340042
98TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.99051321
99ZFP281_18757296_ChIP-ChIP_E14_Mouse0.99006031
100VDR_24787735_ChIP-Seq_THP-1_Human0.99004597
101RNF2_27304074_Chip-Seq_ESCs_Mouse0.98328841
102KDM2B_26808549_Chip-Seq_K562_Human0.96639330
103SMAD4_21741376_ChIP-Seq_HESCs_Human0.96392895
104TP53_18474530_ChIP-ChIP_U2OS_Human0.96189904
105EED_16625203_ChIP-ChIP_MESCs_Mouse0.96000731
106P300_27058665_Chip-Seq_ZR-75-30cells_Human0.94862074
107KDM2B_26808549_Chip-Seq_DND41_Human0.94639283
108NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94413839
109SMC1_22415368_ChIP-Seq_MEFs_Mouse0.94337780
110GATA3_24758297_ChIP-Seq_MCF-7_Human0.94166262
111* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.93602541
112FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.93599761
113EZH2_27304074_Chip-Seq_ESCs_Mouse0.93591620
114EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.93559551
115AR_21572438_ChIP-Seq_LNCaP_Human0.93382820
116SMAD3_21741376_ChIP-Seq_HESCs_Human0.93267424
117* EZH2_27294783_Chip-Seq_ESCs_Mouse0.92636345
118IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.92431592
119TCF4_18268006_ChIP-ChIP_LS174T_Human0.92229785
120CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.90723064
121BRD4_25478319_ChIP-Seq_HGPS_Human0.90399584
122VDR_22108803_ChIP-Seq_LS180_Human0.89690630
123UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.89584849
124LXR_22292898_ChIP-Seq_THP-1_Human0.89421767
125SALL4_18804426_ChIP-ChIP_XEN_Mouse0.89218378
126TP53_16413492_ChIP-PET_HCT116_Human0.89184255
127TP53_20018659_ChIP-ChIP_R1E_Mouse0.89106138
128CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.88709038
129AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.88294351
130PPARA_22158963_ChIP-Seq_LIVER_Mouse0.87638273
131* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.87459071
132SOX2_21211035_ChIP-Seq_LN229_Gbm0.87059778
133PCGF2_27294783_Chip-Seq_NPCs_Mouse0.87054817
134DROSHA_22980978_ChIP-Seq_HELA_Human0.86990111
135SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.85621695
136SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.85310481
137IGF1R_20145208_ChIP-Seq_DFB_Human0.85121839
138JARID2_20064375_ChIP-Seq_MESCs_Mouse0.83950687
139MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.83839851
140FOXM1_26456572_ChIP-Seq_MCF-7_Human0.83557257
141SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.82881489
142* TCF4_23295773_ChIP-Seq_U87_Human0.82646853
143ZFP57_27257070_Chip-Seq_ESCs_Mouse0.82319754
144TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82283166
145PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80521662

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis6.17599388
2MP0004084_abnormal_cardiac_muscle5.07511855
3MP0000751_myopathy4.51035740
4MP0004036_abnormal_muscle_relaxation3.89296942
5MP0004215_abnormal_myocardial_fiber3.82301492
6MP0005330_cardiomyopathy3.62969593
7MP0003646_muscle_fatigue3.43801312
8MP0000749_muscle_degeneration3.11686549
9MP0008438_abnormal_cutaneous_collagen2.80277356
10MP0004087_abnormal_muscle_fiber2.77889971
11MP0002972_abnormal_cardiac_muscle2.66947335
12MP0000750_abnormal_muscle_regeneration2.61350958
13MP0005620_abnormal_muscle_contractility2.46917757
14MP0008775_abnormal_heart_ventricle2.40357008
15MP0010630_abnormal_cardiac_muscle2.38567481
16MP0003137_abnormal_impulse_conducting2.28746968
17MP0005385_cardiovascular_system_phenoty2.23338055
18MP0001544_abnormal_cardiovascular_syste2.23338055
19MP0006138_congestive_heart_failure2.21601681
20MP0004484_altered_response_of2.16896256
21MP0004130_abnormal_muscle_cell2.16890436
22MP0002106_abnormal_muscle_physiology2.00240438
23MP0003828_pulmonary_edema1.99541911
24MP0004145_abnormal_muscle_electrophysio1.97713524
25MP0005275_abnormal_skin_tensile1.87057109
26MP0003705_abnormal_hypodermis_morpholog1.86147735
27MP0002269_muscular_atrophy1.77804658
28MP0004085_abnormal_heartbeat1.76582704
29MP0005369_muscle_phenotype1.71849962
30MP0004272_abnormal_basement_membrane1.71357621
31MP0000759_abnormal_skeletal_muscle1.66903349
32MP0000747_muscle_weakness1.60569759
33MP0003279_aneurysm1.59215404
34MP0005595_abnormal_vascular_smooth1.51314995
35MP0005503_abnormal_tendon_morphology1.44298068
36MP0010368_abnormal_lymphatic_system1.43554495
37MP0001958_emphysema1.41223559
38MP0005623_abnormal_meninges_morphology1.37144958
39MP0001661_extended_life_span1.35035660
40MP0003566_abnormal_cell_adhesion1.33503755
41MP0003950_abnormal_plasma_membrane1.33010412
42MP0005666_abnormal_adipose_tissue1.31922543
43MP0002127_abnormal_cardiovascular_syste1.30319758
44MP0003567_abnormal_fetal_cardiomyocyte1.29544868
45MP0004233_abnormal_muscle_weight1.28407797
46MP0003221_abnormal_cardiomyocyte_apopto1.27711778
47MP0000733_abnormal_muscle_development1.22676303
48MP0004510_myositis1.22446181
49MP0002108_abnormal_muscle_morphology1.19871101
50MP0005167_abnormal_blood-brain_barrier1.15076760
51MP0000516_abnormal_urinary_system1.14925724
52MP0005367_renal/urinary_system_phenotyp1.14925724
53MP0000767_abnormal_smooth_muscle1.14656253
54MP0009384_cardiac_valve_regurgitation1.14421295
55MP0000266_abnormal_heart_morphology1.13744800
56MP0010386_abnormal_urinary_bladder1.13076884
57MP0003724_increased_susceptibility_to1.12078145
58MP0002234_abnormal_pharynx_morphology1.07840011
59MP0006054_spinal_hemorrhage1.06509226
60MP0004185_abnormal_adipocyte_glucose1.05483703
61MP0001664_abnormal_digestion1.05025522
62MP0005451_abnormal_body_composition1.04544756
63MP0000534_abnormal_ureter_morphology1.02440454
64MP0000537_abnormal_urethra_morphology1.00372449
65MP0000343_altered_response_to0.97376902
66MP0009780_abnormal_chondrocyte_physiolo0.97088119
67MP0000230_abnormal_systemic_arterial0.96765942
68MP0005375_adipose_tissue_phenotype0.95901458
69MP0003941_abnormal_skin_development0.94780627
70MP0001879_abnormal_lymphatic_vessel0.94248518
71MP0003879_abnormal_hair_cell0.93017514
72MP0002128_abnormal_blood_circulation0.91847581
73MP0002332_abnormal_exercise_endurance0.90474781
74MP0005165_increased_susceptibility_to0.88338960
75MP0003303_peritoneal_inflammation0.88273723
76MP0003385_abnormal_body_wall0.85382709
77MP0000013_abnormal_adipose_tissue0.85192782
78MP0005377_hearing/vestibular/ear_phenot0.81322508
79MP0003878_abnormal_ear_physiology0.81322508
80MP0002933_joint_inflammation0.78853634
81MP0002254_reproductive_system_inflammat0.78294167
82MP0003045_fibrosis0.77622741
83MP0005164_abnormal_response_to0.76022183
84MP0002925_abnormal_cardiovascular_devel0.75443724
85MP0005670_abnormal_white_adipose0.73730093
86MP0001299_abnormal_eye_distance/0.73403971
87MP0002998_abnormal_bone_remodeling0.71156241
88MP0002168_other_aberrant_phenotype0.71044938
89MP0000003_abnormal_adipose_tissue0.70969059
90MP0010234_abnormal_vibrissa_follicle0.70859127
91MP0002295_abnormal_pulmonary_circulatio0.69779938
92MP0004147_increased_porphyrin_level0.69543637
93MP0005187_abnormal_penis_morphology0.68630829
94MP0005023_abnormal_wound_healing0.68598970
95MP0002971_abnormal_brown_adipose0.68408429
96MP0000249_abnormal_blood_vessel0.66595665
97MP0001756_abnormal_urination0.65707193
98MP0005508_abnormal_skeleton_morphology0.65523253
99MP0001614_abnormal_blood_vessel0.65201833
100MP0000428_abnormal_craniofacial_morphol0.65201713
101MP0009250_abnormal_appendicular_skeleto0.64901204
102MP0000462_abnormal_digestive_system0.64620727
103MP0006036_abnormal_mitochondrial_physio0.63259428
104MP0001270_distended_abdomen0.61996241
105MP0002249_abnormal_larynx_morphology0.61416990
106MP0009115_abnormal_fat_cell0.58732174
107MP0000762_abnormal_tongue_morphology0.58544695
108MP0003935_abnormal_craniofacial_develop0.58063735
109MP0003300_gastrointestinal_ulcer0.57693862
110MP0000538_abnormal_urinary_bladder0.57289961
111MP0002166_altered_tumor_susceptibility0.57189866
112MP0002896_abnormal_bone_mineralization0.56843986
113MP0005266_abnormal_metabolism0.56514397
114MP0005248_abnormal_Harderian_gland0.55621584
115MP0001485_abnormal_pinna_reflex0.55123696
116MP0001533_abnormal_skeleton_physiology0.54314940
117MP0001501_abnormal_sleep_pattern0.51263590
118MP0008004_abnormal_stomach_pH0.51018089
119MP0003942_abnormal_urinary_system0.50448539
120MP0003091_abnormal_cell_migration0.49541715
121MP0002115_abnormal_skeleton_extremities0.48974363
122MP0002060_abnormal_skin_morphology0.48655782
123MP0005390_skeleton_phenotype0.46441232
124MP0005166_decreased_susceptibility_to0.46217949
125MP0005409_darkened_coat_color0.42675929
126MP0004883_abnormal_blood_vessel0.42628906
127MP0005171_absent_coat_pigmentation0.41897023

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)7.09633217
2Ventricular tachycardia (HP:0004756)5.74461643
3Right ventricular cardiomyopathy (HP:0011663)5.23056021
4Muscle fiber splitting (HP:0003555)5.22213057
5Calf muscle hypertrophy (HP:0008981)5.16082632
6Abnormality of the calf musculature (HP:0001430)4.96805361
7Hyporeflexia of lower limbs (HP:0002600)4.81279518
8Atrial fibrillation (HP:0005110)4.79868677
9Lipoatrophy (HP:0100578)4.62455748
10Aortic aneurysm (HP:0004942)4.59499742
11Muscle hypertrophy of the lower extremities (HP:0008968)4.56757818
12Primary atrial arrhythmia (HP:0001692)4.45307771
13Exercise-induced muscle cramps (HP:0003710)4.30082572
14Supraventricular tachycardia (HP:0004755)4.26159235
15Supraventricular arrhythmia (HP:0005115)4.23739650
16Exercise-induced myalgia (HP:0003738)4.20061209
17Aortic dissection (HP:0002647)4.02328423
18Increased connective tissue (HP:0009025)4.00385084
19Type 1 muscle fiber predominance (HP:0003803)3.88528349
20Facial diplegia (HP:0001349)3.82480825
21Subaortic stenosis (HP:0001682)3.82320344
22Abnormality of the left ventricular outflow tract (HP:0011103)3.82320344
23Syncope (HP:0001279)3.80347660
24Dilated cardiomyopathy (HP:0001644)3.66844078
25Bundle branch block (HP:0011710)3.66669672
26Palpitations (HP:0001962)3.49869179
27EMG: myopathic abnormalities (HP:0003458)3.49560193
28Prolonged QT interval (HP:0001657)3.44180617
29Asymmetric septal hypertrophy (HP:0001670)3.33784806
30Ventricular arrhythmia (HP:0004308)3.31219717
31Myoglobinuria (HP:0002913)3.30702489
32Broad metatarsal (HP:0001783)3.08097641
33Atrioventricular block (HP:0001678)3.08045565
34Heart block (HP:0012722)3.06303401
35Scapular winging (HP:0003691)3.02367083
36Ankle contracture (HP:0006466)3.02203331
37Difficulty running (HP:0009046)2.97738293
38Hypoplastic ischia (HP:0003175)2.97527632
39Abnormal atrioventricular conduction (HP:0005150)2.95436002
40Increased density of long bones (HP:0006392)2.95030147
41Mildly elevated creatine phosphokinase (HP:0008180)2.88520799
42Ventricular fibrillation (HP:0001663)2.86670399
43Increased variability in muscle fiber diameter (HP:0003557)2.84139818
44Difficulty climbing stairs (HP:0003551)2.83047620
45Centrally nucleated skeletal muscle fibers (HP:0003687)2.80815530
46Papilledema (HP:0001085)2.77843100
47Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.77605230
48Areflexia of lower limbs (HP:0002522)2.74217019
49Myotonia (HP:0002486)2.70965916
50Cerebral aneurysm (HP:0004944)2.65925952
51Aneurysm (HP:0002617)2.63424964
52Abnormality of the ischium (HP:0003174)2.61926559
53Abnormality of skeletal muscle fiber size (HP:0012084)2.53286442
54Limb-girdle muscle atrophy (HP:0003797)2.49248643
55Bulbar palsy (HP:0001283)2.47545932
56Rimmed vacuoles (HP:0003805)2.46540712
57Testicular atrophy (HP:0000029)2.43583255
58Ulnar deviation of the wrist (HP:0003049)2.37335982
59Hip contracture (HP:0003273)2.33083959
60Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.29808174
61Premature rupture of membranes (HP:0001788)2.29802773
62Protrusio acetabuli (HP:0003179)2.29721111
63Bicuspid aortic valve (HP:0001647)2.28385992
64Rhabdomyolysis (HP:0003201)2.26858263
65Complement deficiency (HP:0004431)2.25930556
66Distal lower limb muscle weakness (HP:0009053)2.25655492
67Abnormal EKG (HP:0003115)2.25626655
68Neck muscle weakness (HP:0000467)2.20293634
69Frequent falls (HP:0002359)2.18802792
70Muscle fiber inclusion bodies (HP:0100299)2.13976410
71Decreased circulating renin level (HP:0003351)2.07683083
72Malnutrition (HP:0004395)2.05991747
73Lymphangioma (HP:0100764)2.05667804
74Abnormality of the foot musculature (HP:0001436)2.05504990
75Round ear (HP:0100830)2.04220793
76Palmoplantar keratoderma (HP:0000982)2.04220335
77Spinal rigidity (HP:0003306)2.01583621
78Knee flexion contracture (HP:0006380)1.97789773
79Pulmonary artery stenosis (HP:0004415)1.97223898
80Dysmetric saccades (HP:0000641)1.96230069
81Foot dorsiflexor weakness (HP:0009027)1.95117859
82Long toe (HP:0010511)1.94620371
83Left ventricular hypertrophy (HP:0001712)1.92532027
84Steppage gait (HP:0003376)1.91709008
85Persistence of primary teeth (HP:0006335)1.91030682
86Shallow orbits (HP:0000586)1.91001649
87Stroke (HP:0001297)1.89615071
88Vascular tortuosity (HP:0004948)1.89363080
89Generalized muscle weakness (HP:0003324)1.88733637
90Bradycardia (HP:0001662)1.88300979
91Myopathic facies (HP:0002058)1.88218581
92Distal arthrogryposis (HP:0005684)1.88190897
93Abnormality of the 4th metacarpal (HP:0010012)1.87062664
94Hypoplasia of the iris (HP:0007676)1.86153593
95Rectal prolapse (HP:0002035)1.85746490
96Gowers sign (HP:0003391)1.84781055
97Conjunctival hamartoma (HP:0100780)1.84417508
98Proximal amyotrophy (HP:0007126)1.83758516
99Limited hip movement (HP:0008800)1.83386802
100Absent phalangeal crease (HP:0006109)1.83094081
101Ketoacidosis (HP:0001993)1.82699812
102Sudden cardiac death (HP:0001645)1.82497506
103Short hallux (HP:0010109)1.79288282
104Neoplasm of the heart (HP:0100544)1.78695949
105Calcaneovalgus deformity (HP:0001848)1.78692754
106Abnormality of the shoulder girdle musculature (HP:0001435)1.78045752
107Broad ribs (HP:0000885)1.77960195
108Abnormality of complement system (HP:0005339)1.76493508
109Overgrowth (HP:0001548)1.75721448
110Bell-shaped thorax (HP:0001591)1.75624440
111Abnormality of the pubic bones (HP:0003172)1.72458937
112Mitral valve prolapse (HP:0001634)1.71599642
113Osteolytic defects of the phalanges of the hand (HP:0009771)1.71171809
114Osteolytic defects of the hand bones (HP:0009699)1.71171809
115Dilatation of the ascending aorta (HP:0005111)1.70855295
116Nemaline bodies (HP:0003798)1.70662885
117Hematochezia (HP:0002573)1.68217741
118Wrist flexion contracture (HP:0001239)1.67936310
119Aplasia/Hypoplasia of the hallux (HP:0008362)1.67666435
120Congestive heart failure (HP:0001635)1.67259996
121Hamartoma of the eye (HP:0010568)1.66123290
122Distal lower limb amyotrophy (HP:0008944)1.65972866
123Hypoglycemic coma (HP:0001325)1.65867915
124Muscular dystrophy (HP:0003560)1.62415773
125EMG: neuropathic changes (HP:0003445)1.61928445
126Gastrointestinal dysmotility (HP:0002579)1.60826179
127Aortic regurgitation (HP:0001659)1.60523259
128Limb-girdle muscle weakness (HP:0003325)1.59903726

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN6.36291899
2MYLK6.02392240
3DMPK3.75110038
4LMTK23.63019485
5TRIB33.14991677
6DDR23.02008696
7PKN22.71257278
8OBSCN2.54060449
9PHKG12.49293267
10PHKG22.49293267
11PIK3CA2.11955297
12PDK32.05897704
13PDK42.05897704
14LATS11.98125629
15RIPK11.69621032
16PDGFRA1.60772178
17TIE11.60222258
18PDK21.58488112
19BCKDK1.53352300
20SIK11.47650207
21PIK3CG1.33931078
22PAK21.31694405
23ILK1.28815286
24STK391.23550441
25PAK31.22654078
26ROCK11.21939163
27TGFBR21.20054192
28CDC42BPA1.19999454
29MAPKAPK31.12862067
30TRPM71.11146509
31FRK1.06058963
32NLK1.05295940
33PTK61.01784116
34EEF2K1.01515068
35MUSK0.99035242
36STK240.97750645
37EPHB20.97641910
38AKT30.97502559
39STK38L0.95810583
40MOS0.95354383
41PRKD10.94654967
42NEK10.92964716
43MAP3K60.90618470
44DAPK30.89801382
45FER0.87819321
46MAPK70.87318448
47EPHB10.80871347
48ROCK20.80776237
49CAMK2D0.78545110
50MAP3K70.76700839
51WNK40.75580741
52LIMK10.73832286
53MAPK40.73710072
54MARK20.72552923
55WNK10.72531568
56LRRK20.71933236
57EPHA30.70072061
58NUAK10.69927176
59ERN10.67877709
60SGK20.67396200
61RPS6KC10.64477574
62RPS6KL10.64477574
63LATS20.64292610
64INSRR0.63108925
65MAP3K30.62484797
66PTK2B0.61312505
67MELK0.60760190
68PINK10.58192856
69FGFR20.53920762
70PRKAA20.53602731
71PRKAA10.53481353
72MAP3K100.53195758
73FLT30.52875410
74MAPK120.52146575
75RPS6KA60.51906090
76STK380.51400681
77SGK30.51144692
78RPS6KA20.49852302
79MARK30.48945281
80CAMK2G0.48556855
81MAP3K50.48231170
82FGFR30.47364349
83MTOR0.47192686
84STK30.46294659
85GRK70.45962151
86PDGFRB0.44184284
87STK40.43555097
88CAMK2A0.43335252
89KDR0.42975435
90ZAK0.42457861
91SGK2230.42403623
92SGK4940.42403623
93ICK0.41724736
94NEK90.40728544
95MAP2K30.40443166
96PRKD20.40008604
97CAMK1D0.39535688
98PRKACB0.39441047
99TESK10.39237561
100MET0.38423953
101CAMK40.37235055
102CAMK1G0.36086413
103CAMK10.36067246
104PTK20.35957103
105PRKG10.35822764
106CAMK2B0.34212493
107ACVR1B0.34014999
108MAP3K130.33775240
109RET0.33059378
110FGFR40.32525597
111JAK10.31849183
112FGFR10.31768936
113PKN10.30669757
114PRKCH0.30061813
115ADRBK10.29508672
116BLK0.28641807
117TBK10.27866010
118PDPK10.27747308
119PRKACA0.27562274
120PRKCE0.26885978
121MAP3K10.26775017
122MAP2K10.26717278
123PRKACG0.26434712
124JAK20.26321915
125RPS6KA10.25186601
126GSK3A0.24211037
127PAK40.23879714
128AKT20.23626121

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.58343063
2Dilated cardiomyopathy_Homo sapiens_hsa054143.85649838
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.82992326
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.38775917
5Cardiac muscle contraction_Homo sapiens_hsa042603.32367454
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.80157347
7Propanoate metabolism_Homo sapiens_hsa006402.62638887
8Fatty acid degradation_Homo sapiens_hsa000712.54481723
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.20757688
10ECM-receptor interaction_Homo sapiens_hsa045122.06133653
11Focal adhesion_Homo sapiens_hsa045101.98916072
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.92713185
13Fatty acid metabolism_Homo sapiens_hsa012121.87136335
14Carbon metabolism_Homo sapiens_hsa012001.72665276
15Viral myocarditis_Homo sapiens_hsa054161.71671422
16Parkinsons disease_Homo sapiens_hsa050121.63734158
17Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.61663207
18Oxidative phosphorylation_Homo sapiens_hsa001901.51491370
19Circadian rhythm_Homo sapiens_hsa047101.50994306
20Ovarian steroidogenesis_Homo sapiens_hsa049131.49919583
21Vascular smooth muscle contraction_Homo sapiens_hsa042701.46169839
22Tight junction_Homo sapiens_hsa045301.35294774
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.34095441
24Alzheimers disease_Homo sapiens_hsa050101.33620671
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.33327069
26Insulin resistance_Homo sapiens_hsa049311.32577865
27Adherens junction_Homo sapiens_hsa045201.31376804
28cGMP-PKG signaling pathway_Homo sapiens_hsa040221.30382360
29Pyruvate metabolism_Homo sapiens_hsa006201.25087491
30PPAR signaling pathway_Homo sapiens_hsa033201.20244291
31Proteoglycans in cancer_Homo sapiens_hsa052051.16262396
32Protein digestion and absorption_Homo sapiens_hsa049741.14940850
33Amoebiasis_Homo sapiens_hsa051461.14212092
34Adipocytokine signaling pathway_Homo sapiens_hsa049201.09443299
35Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.06347950
36Insulin signaling pathway_Homo sapiens_hsa049100.98313995
37Lysine degradation_Homo sapiens_hsa003100.96358899
38Complement and coagulation cascades_Homo sapiens_hsa046100.96043552
39Circadian entrainment_Homo sapiens_hsa047130.95091729
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.93544844
41Salivary secretion_Homo sapiens_hsa049700.92072073
42Malaria_Homo sapiens_hsa051440.91424326
43Small cell lung cancer_Homo sapiens_hsa052220.89508658
44Glucagon signaling pathway_Homo sapiens_hsa049220.88798732
45Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.88264516
46Butanoate metabolism_Homo sapiens_hsa006500.85860486
47Huntingtons disease_Homo sapiens_hsa050160.85653535
48AMPK signaling pathway_Homo sapiens_hsa041520.84933532
49Basal cell carcinoma_Homo sapiens_hsa052170.83179285
50Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.81920201
51Starch and sucrose metabolism_Homo sapiens_hsa005000.81369381
52Oxytocin signaling pathway_Homo sapiens_hsa049210.81257382
53AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.81232227
54Phospholipase D signaling pathway_Homo sapiens_hsa040720.80845744
55Hippo signaling pathway_Homo sapiens_hsa043900.80213365
56Leukocyte transendothelial migration_Homo sapiens_hsa046700.79082644
57Sulfur metabolism_Homo sapiens_hsa009200.78760128
58Histidine metabolism_Homo sapiens_hsa003400.78596758
59ABC transporters_Homo sapiens_hsa020100.75653679
60Prion diseases_Homo sapiens_hsa050200.75173760
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.74685840
62Gastric acid secretion_Homo sapiens_hsa049710.73201154
63Regulation of actin cytoskeleton_Homo sapiens_hsa048100.72658106
64HIF-1 signaling pathway_Homo sapiens_hsa040660.70877319
65Pancreatic secretion_Homo sapiens_hsa049720.70430593
66Notch signaling pathway_Homo sapiens_hsa043300.69414048
67Insulin secretion_Homo sapiens_hsa049110.68084033
68Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68059652
69Glycosaminoglycan degradation_Homo sapiens_hsa005310.66848013
70Pertussis_Homo sapiens_hsa051330.66303028
71Central carbon metabolism in cancer_Homo sapiens_hsa052300.65819892
72Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.64948255
73Calcium signaling pathway_Homo sapiens_hsa040200.63104251
74Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62764485
75Staphylococcus aureus infection_Homo sapiens_hsa051500.62287310
76Fatty acid biosynthesis_Homo sapiens_hsa000610.62118479
77Platelet activation_Homo sapiens_hsa046110.61769700
78Tryptophan metabolism_Homo sapiens_hsa003800.60016031
79Tyrosine metabolism_Homo sapiens_hsa003500.58989853
80Type II diabetes mellitus_Homo sapiens_hsa049300.58402084
81Renin secretion_Homo sapiens_hsa049240.57846689
82Osteoclast differentiation_Homo sapiens_hsa043800.57550353
83Arginine biosynthesis_Homo sapiens_hsa002200.56209660
84Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.55894211
85Cholinergic synapse_Homo sapiens_hsa047250.55676815
86MAPK signaling pathway_Homo sapiens_hsa040100.55664642
87Biosynthesis of amino acids_Homo sapiens_hsa012300.55515884
88TGF-beta signaling pathway_Homo sapiens_hsa043500.53137540
89beta-Alanine metabolism_Homo sapiens_hsa004100.52239026
90PI3K-Akt signaling pathway_Homo sapiens_hsa041510.52014991
91Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.51197177
92Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.51070862
93Dorso-ventral axis formation_Homo sapiens_hsa043200.50375790
94TNF signaling pathway_Homo sapiens_hsa046680.49969292
95Long-term potentiation_Homo sapiens_hsa047200.49958464
96Toxoplasmosis_Homo sapiens_hsa051450.49384628
97Fatty acid elongation_Homo sapiens_hsa000620.48875139
98Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.48514763
99Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.47383246
100Prolactin signaling pathway_Homo sapiens_hsa049170.46784350
101cAMP signaling pathway_Homo sapiens_hsa040240.45642464
102Jak-STAT signaling pathway_Homo sapiens_hsa046300.45525821
103mTOR signaling pathway_Homo sapiens_hsa041500.44488999
104Melanogenesis_Homo sapiens_hsa049160.43995396
105Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.43020514
106Wnt signaling pathway_Homo sapiens_hsa043100.42344653
107Pathways in cancer_Homo sapiens_hsa052000.42292429
108Arginine and proline metabolism_Homo sapiens_hsa003300.42263301
109Chronic myeloid leukemia_Homo sapiens_hsa052200.41635049
110Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41119664
111Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.41033625
112Other glycan degradation_Homo sapiens_hsa005110.40924103
113Phosphatidylinositol signaling system_Homo sapiens_hsa040700.40864654
114Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40409799
115Bladder cancer_Homo sapiens_hsa052190.40386905
116Endometrial cancer_Homo sapiens_hsa052130.40255868
117Renal cell carcinoma_Homo sapiens_hsa052110.39955773
118Bile secretion_Homo sapiens_hsa049760.38577561
119Renin-angiotensin system_Homo sapiens_hsa046140.37630736
120Estrogen signaling pathway_Homo sapiens_hsa049150.36775133
121Glioma_Homo sapiens_hsa052140.36098008
122Melanoma_Homo sapiens_hsa052180.35412684
123Choline metabolism in cancer_Homo sapiens_hsa052310.35361696
124Hedgehog signaling pathway_Homo sapiens_hsa043400.35333346
125Serotonergic synapse_Homo sapiens_hsa047260.35130384
126Toll-like receptor signaling pathway_Homo sapiens_hsa046200.34773593
127MicroRNAs in cancer_Homo sapiens_hsa052060.33899182
128Mineral absorption_Homo sapiens_hsa049780.33300971
129Galactose metabolism_Homo sapiens_hsa000520.31392206
130Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.31336920
131Rap1 signaling pathway_Homo sapiens_hsa040150.31237668
132VEGF signaling pathway_Homo sapiens_hsa043700.30934527
133FoxO signaling pathway_Homo sapiens_hsa040680.28674960
134Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28647364
135Gap junction_Homo sapiens_hsa045400.28586378
136GnRH signaling pathway_Homo sapiens_hsa049120.27668256
137Phenylalanine metabolism_Homo sapiens_hsa003600.25839517

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