PGM3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the phosphohexose mutase family. The encoded protein mediates both glycogen formation and utilization by catalyzing the interconversion of glucose-1-phosphate and glucose-6-phosphate. A non-synonymous single nucleotide polymorphism in this gene may play a role in resistance to diabetic nephropathy and neuropathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)5.66632990
2Golgi transport vesicle coating (GO:0048200)5.66632990
3purine nucleobase biosynthetic process (GO:0009113)4.77093472
4signal peptide processing (GO:0006465)4.53723884
5nucleobase biosynthetic process (GO:0046112)4.39918820
6COPII vesicle coating (GO:0048208)4.35415488
7cullin deneddylation (GO:0010388)4.22788914
8protein deneddylation (GO:0000338)3.96457428
9folic acid-containing compound biosynthetic process (GO:0009396)3.91585266
10maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.82160368
11formation of translation preinitiation complex (GO:0001731)3.76565823
12transcription elongation from RNA polymerase III promoter (GO:0006385)3.74238757
13termination of RNA polymerase III transcription (GO:0006386)3.74238757
14GDP-mannose metabolic process (GO:0019673)3.67540727
15folic acid metabolic process (GO:0046655)3.53860130
16proteasome assembly (GO:0043248)3.52577384
17rRNA modification (GO:0000154)3.50785425
18* nucleotide-sugar biosynthetic process (GO:0009226)3.44380801
19pteridine-containing compound biosynthetic process (GO:0042559)3.41555721
207-methylguanosine mRNA capping (GO:0006370)3.37672457
217-methylguanosine RNA capping (GO:0009452)3.37438662
22RNA capping (GO:0036260)3.37438662
23* UDP-N-acetylglucosamine metabolic process (GO:0006047)3.33353546
24protein retention in ER lumen (GO:0006621)3.25911051
25mitotic metaphase plate congression (GO:0007080)3.24608544
26RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.22962171
27tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.22962171
28maturation of SSU-rRNA (GO:0030490)3.19811410
29negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.19809692
30ribosome assembly (GO:0042255)3.18856558
31ribosome biogenesis (GO:0042254)3.14219747
32rRNA methylation (GO:0031167)3.13443730
33positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.11270684
34anterior/posterior axis specification, embryo (GO:0008595)3.10904344
35peptidyl-histidine modification (GO:0018202)3.09127143
36L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.07390072
37regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.05120841
38regulation of cellular amino acid metabolic process (GO:0006521)3.01113421
39transcription from RNA polymerase I promoter (GO:0006360)2.99247149
40lactate metabolic process (GO:0006089)2.99190778
41termination of RNA polymerase I transcription (GO:0006363)2.98379453
42DNA double-strand break processing (GO:0000729)2.98065011
43proline biosynthetic process (GO:0006561)2.96941627
44amino acid salvage (GO:0043102)2.96020794
45L-methionine salvage (GO:0071267)2.96020794
46L-methionine biosynthetic process (GO:0071265)2.96020794
47negative regulation of ligase activity (GO:0051352)2.96005158
48negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.96005158
49DNA deamination (GO:0045006)2.94397975
50anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.93180554
51regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.92355783
52DNA replication checkpoint (GO:0000076)2.92232989
53folic acid-containing compound metabolic process (GO:0006760)2.90050353
54tRNA aminoacylation for protein translation (GO:0006418)2.89584969
55transcription elongation from RNA polymerase I promoter (GO:0006362)2.89580809
56tetrahydrofolate metabolic process (GO:0046653)2.89051705
57* dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.86967379
58pyrimidine-containing compound transmembrane transport (GO:0072531)2.84210754
59ER overload response (GO:0006983)2.81884217
60ribonucleoprotein complex biogenesis (GO:0022613)2.81632983
61amino acid activation (GO:0043038)2.81459646
62tRNA aminoacylation (GO:0043039)2.81459646
63transcription-coupled nucleotide-excision repair (GO:0006283)2.81154699
64SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.80561955
65serine family amino acid biosynthetic process (GO:0009070)2.80153019
66antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.79991043
67cotranslational protein targeting to membrane (GO:0006613)2.76951719
68L-serine metabolic process (GO:0006563)2.76548165
69ribosomal large subunit biogenesis (GO:0042273)2.76201271
70positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.76006884
71protein peptidyl-prolyl isomerization (GO:0000413)2.75953278
72pteridine-containing compound metabolic process (GO:0042558)2.75452085
73DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.75028532
74signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.74514706
75signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.74514706
76signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.74514706
77transcription initiation from RNA polymerase I promoter (GO:0006361)2.73611163
78protein targeting to ER (GO:0045047)2.72533062
79signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.72338183
80intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.72338183
81folic acid transport (GO:0015884)2.71778189
82regulation of mitochondrial translation (GO:0070129)2.70626342
83pseudouridine synthesis (GO:0001522)2.70345411
84glycine metabolic process (GO:0006544)2.70212735
85maturation of 5.8S rRNA (GO:0000460)2.69620759
86signal transduction involved in DNA integrity checkpoint (GO:0072401)2.69113901
87signal transduction involved in DNA damage checkpoint (GO:0072422)2.69113901
88positive regulation of protein autophosphorylation (GO:0031954)2.68773025
89translation (GO:0006412)2.68032109
90spliceosomal snRNP assembly (GO:0000387)2.67593735
91IMP biosynthetic process (GO:0006188)2.67039871
92methionine biosynthetic process (GO:0009086)2.66584273
93antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.66323936
94positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.66162053
95metaphase plate congression (GO:0051310)2.65742914
96signal transduction involved in cell cycle checkpoint (GO:0072395)2.65370329
97nucleotide transmembrane transport (GO:1901679)2.64724150
98positive regulation of ligase activity (GO:0051351)2.64242363
99* nucleotide-sugar metabolic process (GO:0009225)2.63933409
100protein localization to endoplasmic reticulum (GO:0070972)2.62915978
101ribosomal small subunit assembly (GO:0000028)2.61282719
102sulfur amino acid biosynthetic process (GO:0000097)2.60832196
103transcription elongation from RNA polymerase II promoter (GO:0006368)2.60344057
104chondrocyte proliferation (GO:0035988)2.59744852
105retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.59263473
106antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.58610873
107protein maturation by protein folding (GO:0022417)2.58217327
108non-recombinational repair (GO:0000726)2.57619679
109double-strand break repair via nonhomologous end joining (GO:0006303)2.57619679
110nuclear pore organization (GO:0006999)2.57606940
111female gonad development (GO:0008585)2.57471469
112zinc ion transport (GO:0006829)2.53572456
113nuclear pore complex assembly (GO:0051292)2.52841800
114mitotic sister chromatid cohesion (GO:0007064)2.52561395
115ventricular cardiac muscle cell development (GO:0055015)2.45642682
116cholesterol biosynthetic process (GO:0006695)2.43430218
117regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.43290655
118ER to Golgi vesicle-mediated transport (GO:0006888)2.42750327
119regulation of cholesterol esterification (GO:0010872)2.37149536
120protein prenylation (GO:0018342)2.36560029
121prenylation (GO:0097354)2.36560029
122branched-chain amino acid catabolic process (GO:0009083)2.31797828
123water-soluble vitamin biosynthetic process (GO:0042364)2.30737933
124vesicle coating (GO:0006901)2.30272106
125regulation of centriole replication (GO:0046599)2.30227134
126collagen fibril organization (GO:0030199)2.29599826
127response to X-ray (GO:0010165)2.29346943
128sterol biosynthetic process (GO:0016126)2.29036244
129cell adhesion mediated by integrin (GO:0033627)2.28797327
130regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.24363086
131lysine catabolic process (GO:0006554)2.23815611
132lysine metabolic process (GO:0006553)2.23815611
133high-density lipoprotein particle remodeling (GO:0034375)2.22390577
134regulation of transforming growth factor beta2 production (GO:0032909)2.21448925
135protein heterotetramerization (GO:0051290)2.20964864
136reverse cholesterol transport (GO:0043691)2.20173716
137lipid particle organization (GO:0034389)2.19734943
138synapsis (GO:0007129)2.19442193
139acrosome assembly (GO:0001675)2.19146905
140CENP-A containing nucleosome assembly (GO:0034080)2.18924695
141negative regulation of keratinocyte proliferation (GO:0010839)2.18426130
142chromatin remodeling at centromere (GO:0031055)2.18266925
143peptidyl-cysteine modification (GO:0018198)2.17778514
144sequestering of extracellular ligand from receptor (GO:0035581)2.17571636
145response to redox state (GO:0051775)2.17529044
146regulation of DNA endoreduplication (GO:0032875)2.15742976
147regulation of acyl-CoA biosynthetic process (GO:0050812)2.13175117
148regulation of sulfur metabolic process (GO:0042762)2.12717566
149intestinal cholesterol absorption (GO:0030299)2.12473105
150regulation of non-canonical Wnt signaling pathway (GO:2000050)2.12385915
151genitalia morphogenesis (GO:0035112)2.12084895
152negative regulation of lipase activity (GO:0060192)2.11023978
153replication fork processing (GO:0031297)2.10747896
154regulation of coenzyme metabolic process (GO:0051196)2.09707907
155regulation of cofactor metabolic process (GO:0051193)2.09707907
156resolution of meiotic recombination intermediates (GO:0000712)2.09592832
157embryonic foregut morphogenesis (GO:0048617)2.07434208
158negative chemotaxis (GO:0050919)2.07116469
159negative regulation of axon extension involved in axon guidance (GO:0048843)2.05879212
160regulation of Rac protein signal transduction (GO:0035020)2.05619299
1614-hydroxyproline metabolic process (GO:0019471)2.05070833
162regulation of meiosis I (GO:0060631)2.03493801
163paraxial mesoderm development (GO:0048339)2.02639125
164negative regulation of DNA-dependent DNA replication (GO:2000104)2.02459073
165vascular smooth muscle contraction (GO:0014829)2.02165979
166histone exchange (GO:0043486)2.01959065
167retina vasculature morphogenesis in camera-type eye (GO:0061299)2.01478919
168glucuronate metabolic process (GO:0019585)2.01008514
169uronic acid metabolic process (GO:0006063)2.01008514
170regulation of plasminogen activation (GO:0010755)2.00748124
171fatty acid elongation (GO:0030497)2.00217468
172regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)1.99839092
173aldehyde catabolic process (GO:0046185)1.99411333
174cellular glucuronidation (GO:0052695)1.98602642
175spindle checkpoint (GO:0031577)1.98511090
176dorsal/ventral axis specification (GO:0009950)1.97183174
177transcytosis (GO:0045056)1.95395364

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.65813154
2E2F7_22180533_ChIP-Seq_HELA_Human4.32408786
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.24467901
4MYC_18555785_ChIP-Seq_MESCs_Mouse4.04027334
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.76729342
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.50590882
7CREB1_15753290_ChIP-ChIP_HEK293T_Human3.48715400
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.36856713
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.24347962
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.20568033
11CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.81488895
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.80699783
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.80582116
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.76727521
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.61615009
16* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.54465760
17* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.48375757
18VDR_23849224_ChIP-Seq_CD4+_Human2.47950980
19POU3F2_20337985_ChIP-ChIP_501MEL_Human2.46069667
20PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.43255860
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.41241058
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.40085683
23DCP1A_22483619_ChIP-Seq_HELA_Human2.39437149
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.35181085
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.26491279
26PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.16257423
27SRF_21415370_ChIP-Seq_HL-1_Mouse2.11375805
28FUS_26573619_Chip-Seq_HEK293_Human2.10621202
29ELK1_19687146_ChIP-ChIP_HELA_Human2.10303313
30GABP_19822575_ChIP-Seq_HepG2_Human2.08611884
31FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.07730937
32CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.06611706
33* XRN2_22483619_ChIP-Seq_HELA_Human2.06166510
34FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.05812725
35FOXP3_21729870_ChIP-Seq_TREG_Human2.05715027
36FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.03968917
37AR_21909140_ChIP-Seq_LNCAP_Human2.02257960
38CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.01845902
39ZFP57_27257070_Chip-Seq_ESCs_Mouse2.01089165
40E2F4_17652178_ChIP-ChIP_JURKAT_Human1.98394355
41FLI1_27457419_Chip-Seq_LIVER_Mouse1.93770311
42WT1_19549856_ChIP-ChIP_CCG9911_Human1.92535275
43MYCN_18555785_ChIP-Seq_MESCs_Mouse1.87436116
44THAP11_20581084_ChIP-Seq_MESCs_Mouse1.86651384
45GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.85979025
46AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.85501633
47EWS_26573619_Chip-Seq_HEK293_Human1.82938329
48P300_19829295_ChIP-Seq_ESCs_Human1.82669245
49MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.80587704
50POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.78638094
51ZNF274_21170338_ChIP-Seq_K562_Hela1.78592780
52GBX2_23144817_ChIP-Seq_PC3_Human1.78278567
53SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.73870694
54PIAS1_25552417_ChIP-Seq_VCAP_Human1.71136088
55NANOG_18555785_ChIP-Seq_MESCs_Mouse1.71042324
56PCGF2_27294783_Chip-Seq_ESCs_Mouse1.70750649
57ZFX_18555785_ChIP-Seq_MESCs_Mouse1.66886851
58PADI4_21655091_ChIP-ChIP_MCF-7_Human1.65775731
59* ELK1_22589737_ChIP-Seq_MCF10A_Human1.64125393
60MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.63909726
61HOXB4_20404135_ChIP-ChIP_EML_Mouse1.60309101
62SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.60248917
63TTF2_22483619_ChIP-Seq_HELA_Human1.60121974
64YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.59158742
65CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.57865760
66* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.57799423
67YY1_21170310_ChIP-Seq_MESCs_Mouse1.54403364
68EZH2_27294783_Chip-Seq_NPCs_Mouse1.53185252
69TAF15_26573619_Chip-Seq_HEK293_Human1.50129954
70PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.49033980
71OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48500813
72TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.47460487
73BRD4_25478319_ChIP-Seq_HGPS_Human1.47315811
74ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.47229290
75EGR1_23403033_ChIP-Seq_LIVER_Mouse1.44606358
76ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.43958067
77RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.43758996
78HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.43540420
79SUZ12_27294783_Chip-Seq_NPCs_Mouse1.42180732
80VDR_22108803_ChIP-Seq_LS180_Human1.38245080
81ERG_20887958_ChIP-Seq_HPC-7_Mouse1.37715891
82SMAD4_21799915_ChIP-Seq_A2780_Human1.36527893
83CDX2_19796622_ChIP-Seq_MESCs_Mouse1.35376769
84CJUN_26792858_Chip-Seq_BT549_Human1.35161639
85IGF1R_20145208_ChIP-Seq_DFB_Human1.34359964
86POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.32604375
87PCGF2_27294783_Chip-Seq_NPCs_Mouse1.32535489
88KDM5A_27292631_Chip-Seq_BREAST_Human1.32473106
89MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.32195358
90SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.32082906
91CTBP2_25329375_ChIP-Seq_LNCAP_Human1.31863740
92NRF2_20460467_ChIP-Seq_MEFs_Mouse1.30947286
93NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.30947286
94SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.30506181
95SOX17_20123909_ChIP-Seq_XEN_Mouse1.30444449
96SALL1_21062744_ChIP-ChIP_HESCs_Human1.28869693
97TFEB_21752829_ChIP-Seq_HELA_Human1.28305343
98SMAD_19615063_ChIP-ChIP_OVARY_Human1.27960271
99DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.26619032
100NFE2_27457419_Chip-Seq_LIVER_Mouse1.26524192
101NANOG_18555785_Chip-Seq_ESCs_Mouse1.24582906
102SMAD3_21741376_ChIP-Seq_EPCs_Human1.24373833
103TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.24176525
104CDX2_22108803_ChIP-Seq_LS180_Human1.23936893
105TP53_18474530_ChIP-ChIP_U2OS_Human1.23602413
106SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.23521958
107POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.23483538
108* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.23462481
109SALL4_18804426_ChIP-ChIP_XEN_Mouse1.22863641
110FOXM1_26456572_ChIP-Seq_MCF-7_Human1.22150803
111POU5F1_16153702_ChIP-ChIP_HESCs_Human1.21197080
112TRIM28_21343339_ChIP-Seq_HEK293_Human1.19908534
113EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.19470388
114* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.18228279
115SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17913497
116CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.15454751
117SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.15298442
118* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14977980
119CRX_20693478_ChIP-Seq_RETINA_Mouse1.14070840
120PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.13882273
121STAT3_23295773_ChIP-Seq_U87_Human1.12561870
122ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.11651881
123RBPJ_22232070_ChIP-Seq_NCS_Mouse1.11578697
124CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.11455603
125TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.11170884
126TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.10527015
127E2F1_21310950_ChIP-Seq_MCF-7_Human1.08641000
128SOX2_18555785_ChIP-Seq_MESCs_Mouse1.08338711
129KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06748589
130EP300_21415370_ChIP-Seq_HL-1_Mouse1.06636457
131ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06008073
132ER_23166858_ChIP-Seq_MCF-7_Human1.04921279
133E2F1_18555785_Chip-Seq_ESCs_Mouse1.04284368
134BCAT_22108803_ChIP-Seq_LS180_Human1.03919666
135BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.03381236
136P53_22387025_ChIP-Seq_ESCs_Mouse1.03083813
137FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.03001569
138CBP_20019798_ChIP-Seq_JUKART_Human1.02783099
139IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.02783099
140CMYC_18555785_Chip-Seq_ESCs_Mouse1.02555523
141MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.01413052
142TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01397571
143STAT3_1855785_ChIP-Seq_MESCs_Mouse1.00497029
144SUZ12_18555785_Chip-Seq_ESCs_Mouse1.00286060
145NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.98905418
146P300_18555785_Chip-Seq_ESCs_Mouse0.98430733
147TCF4_22108803_ChIP-Seq_LS180_Human0.98131105
148AR_25329375_ChIP-Seq_VCAP_Human0.97695909
149RXR_22158963_ChIP-Seq_LIVER_Mouse0.96800612
150CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.96159339
151NOTCH1_21737748_ChIP-Seq_TLL_Human0.95973133
152SOX2_18555785_Chip-Seq_ESCs_Mouse0.95435856
153JUN_21703547_ChIP-Seq_K562_Human0.93841488
154KLF4_18555785_ChIP-Seq_MESCs_Mouse0.93678437
155CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.93306122
156STAT3_18555785_Chip-Seq_ESCs_Mouse0.93004380
157MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.92684137
158PPARA_22158963_ChIP-Seq_LIVER_Mouse0.90714405
159CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.90536976
160E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.89406934
161KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.89019062
162NANOG_16153702_ChIP-ChIP_HESCs_Human0.87672713
163MYC_18940864_ChIP-ChIP_HL60_Human0.85804285
164TCF3_18692474_ChIP-Seq_MEFs_Mouse0.84885721
165IRF1_19129219_ChIP-ChIP_H3396_Human0.84715742
166FOXM1_23109430_ChIP-Seq_U2OS_Human0.84523163
167CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.83344501
168SOX2_18692474_ChIP-Seq_MEFs_Mouse0.82283418
169SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.81799415
170EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.80071797
171NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.79113426
172KAP1_22055183_ChIP-Seq_ESCs_Mouse0.78688003
173GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.78272315
174CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.77084868
175* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.76980725
176TP63_19390658_ChIP-ChIP_HaCaT_Human0.75946186

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis4.53873321
2MP0003693_abnormal_embryo_hatching3.87293296
3MP0004272_abnormal_basement_membrane3.17144731
4MP0002139_abnormal_hepatobiliary_system3.14185699
5MP0004957_abnormal_blastocyst_morpholog2.98726117
6MP0005365_abnormal_bile_salt2.77302785
7MP0003950_abnormal_plasma_membrane2.52379656
8MP0008058_abnormal_DNA_repair2.41572079
9MP0005085_abnormal_gallbladder_physiolo2.36873893
10* MP0005220_abnormal_exocrine_pancreas2.32582332
11MP0005360_urolithiasis2.32261701
12MP0008057_abnormal_DNA_replication2.32152473
13MP0003283_abnormal_digestive_organ2.29728130
14MP0005503_abnormal_tendon_morphology2.24832027
15MP0003195_calcinosis2.06559072
16MP0003077_abnormal_cell_cycle1.98839252
17MP0003111_abnormal_nucleus_morphology1.98535800
18MP0009780_abnormal_chondrocyte_physiolo1.92811205
19MP0009697_abnormal_copulation1.91751938
20MP0010094_abnormal_chromosome_stability1.89673668
21MP0008932_abnormal_embryonic_tissue1.88331414
22MP0000566_synostosis1.85056681
23MP0003718_maternal_effect1.83345730
24MP0003123_paternal_imprinting1.81120909
25MP0006054_spinal_hemorrhage1.80904940
26MP0008007_abnormal_cellular_replicative1.77244909
27MP0003186_abnormal_redox_activity1.76278796
28MP0001666_abnormal_nutrient_absorption1.75595738
29MP0005379_endocrine/exocrine_gland_phen1.75296170
30MP0008438_abnormal_cutaneous_collagen1.74480070
31MP0005084_abnormal_gallbladder_morpholo1.74446129
32MP0004264_abnormal_extraembryonic_tissu1.65621536
33MP0001299_abnormal_eye_distance/1.61541046
34MP0010386_abnormal_urinary_bladder1.61198309
35MP0005171_absent_coat_pigmentation1.58295661
36MP0002254_reproductive_system_inflammat1.55704968
37MP0009384_cardiac_valve_regurgitation1.50723754
38MP0002102_abnormal_ear_morphology1.49013743
39MP0005408_hypopigmentation1.48613000
40MP0001764_abnormal_homeostasis1.45891821
41MP0010030_abnormal_orbit_morphology1.44205033
42MP0005332_abnormal_amino_acid1.43487722
43MP0000462_abnormal_digestive_system1.42113726
44* MP0001944_abnormal_pancreas_morphology1.41694132
45MP0001542_abnormal_bone_strength1.40732646
46MP0003252_abnormal_bile_duct1.40239927
47MP0002163_abnormal_gland_morphology1.38527700
48MP0002693_abnormal_pancreas_physiology1.38194228
49MP0001730_embryonic_growth_arrest1.35548912
50MP0005623_abnormal_meninges_morphology1.34595255
51MP0002233_abnormal_nose_morphology1.29550805
52MP0003755_abnormal_palate_morphology1.29229387
53MP0005367_renal/urinary_system_phenotyp1.28066558
54MP0000516_abnormal_urinary_system1.28066558
55MP0004043_abnormal_pH_regulation1.27331438
56MP0000372_irregular_coat_pigmentation1.26215358
57MP0010368_abnormal_lymphatic_system1.24909868
58MP0003385_abnormal_body_wall1.22739835
59MP0009379_abnormal_foot_pigmentation1.22689946
60MP0006292_abnormal_olfactory_placode1.21614886
61MP0001661_extended_life_span1.20652968
62MP0000013_abnormal_adipose_tissue1.20141393
63MP0003890_abnormal_embryonic-extraembry1.19085546
64MP0000350_abnormal_cell_proliferation1.15926710
65MP0003786_premature_aging1.14418206
66MP0003122_maternal_imprinting1.13101021
67MP0009643_abnormal_urine_homeostasis1.12998880
68MP0002282_abnormal_trachea_morphology1.12605306
69MP0002938_white_spotting1.11994554
70MP0005083_abnormal_biliary_tract1.09489382
71MP0009250_abnormal_appendicular_skeleto1.08829496
72MP0001984_abnormal_olfaction1.08232743
73MP0008875_abnormal_xenobiotic_pharmacok1.07804606
74MP0004019_abnormal_vitamin_homeostasis1.07654833
75MP0005187_abnormal_penis_morphology1.07552564
76MP0006072_abnormal_retinal_apoptosis1.04832165
77MP0002933_joint_inflammation1.04507034
78MP0004134_abnormal_chest_morphology1.03775368
79MP0003119_abnormal_digestive_system1.01852876
80MP0005253_abnormal_eye_physiology1.01708014
81MP0003566_abnormal_cell_adhesion1.01035069
82MP0000538_abnormal_urinary_bladder1.00843397
83MP0002090_abnormal_vision1.00449576
84MP0005636_abnormal_mineral_homeostasis0.99465229
85MP0010234_abnormal_vibrissa_follicle0.97721803
86MP0008877_abnormal_DNA_methylation0.97627756
87MP0002111_abnormal_tail_morphology0.96371948
88MP0005275_abnormal_skin_tensile0.96066177
89MP0002697_abnormal_eye_size0.95774716
90MP0002877_abnormal_melanocyte_morpholog0.95050227
91MP0000490_abnormal_crypts_of0.94869428
92MP0001697_abnormal_embryo_size0.93546180
93MP0003942_abnormal_urinary_system0.92832508
94MP0003935_abnormal_craniofacial_develop0.92719238
95MP0005508_abnormal_skeleton_morphology0.91939176
96MP0000163_abnormal_cartilage_morphology0.90912611
97MP0002085_abnormal_embryonic_tissue0.90286364
98MP0001672_abnormal_embryogenesis/_devel0.89400336
99MP0005380_embryogenesis_phenotype0.89400336
100MP0010329_abnormal_lipoprotein_level0.88767831
101MP0001243_abnormal_dermal_layer0.88709789
102MP0004215_abnormal_myocardial_fiber0.88670112
103MP0003567_abnormal_fetal_cardiomyocyte0.88598479
104MP0004197_abnormal_fetal_growth/weight/0.88108670
105MP0003937_abnormal_limbs/digits/tail_de0.87734078
106MP0000647_abnormal_sebaceous_gland0.87518541
107MP0003183_abnormal_peptide_metabolism0.87266175
108MP0009703_decreased_birth_body0.86974313
109MP0002138_abnormal_hepatobiliary_system0.86735285
110MP0001756_abnormal_urination0.85722220
111MP0000432_abnormal_head_morphology0.85686356
112MP0005197_abnormal_uvea_morphology0.85503388
113MP0001188_hyperpigmentation0.85190481
114* MP0002080_prenatal_lethality0.85145771
115MP0009333_abnormal_splenocyte_physiolog0.85108236
116MP0005551_abnormal_eye_electrophysiolog0.84891315
117MP0001293_anophthalmia0.84726298
118MP0001915_intracranial_hemorrhage0.83626167
119MP0001177_atelectasis0.82545134
120* MP0003868_abnormal_feces_composition0.81742551
121MP0003136_yellow_coat_color0.81246858
122MP0000762_abnormal_tongue_morphology0.79835611
123MP0001529_abnormal_vocalization0.79657167
124MP0003121_genomic_imprinting0.79544462
125MP0003941_abnormal_skin_development0.78875416
126MP0005395_other_phenotype0.77746859
127MP0004133_heterotaxia0.77560682
128MP0002060_abnormal_skin_morphology0.77364847
129MP0005257_abnormal_intraocular_pressure0.76617245
130MP0003984_embryonic_growth_retardation0.76511306
131MP0000427_abnormal_hair_cycle0.76319060
132MP0002108_abnormal_muscle_morphology0.76049485
133MP0002168_other_aberrant_phenotype0.75618958
134MP0002088_abnormal_embryonic_growth/wei0.74843521
135MP0000358_abnormal_cell_content/0.74086895
136MP0000639_abnormal_adrenal_gland0.73532440
137MP0002084_abnormal_developmental_patter0.72838024
138MP0006036_abnormal_mitochondrial_physio0.71395000
139MP0002751_abnormal_autonomic_nervous0.71181594
140MP0005391_vision/eye_phenotype0.70875814
141MP0002295_abnormal_pulmonary_circulatio0.70505016
142MP0005319_abnormal_enzyme/_coenzyme0.70435075
143MP0001286_abnormal_eye_development0.70127993
144MP0002876_abnormal_thyroid_physiology0.69854360
145MP0002089_abnormal_postnatal_growth/wei0.69657108
146MP0002078_abnormal_glucose_homeostasis0.67455437
147MP0010352_gastrointestinal_tract_polyps0.67296442
148MP0002896_abnormal_bone_mineralization0.66939771
149MP0005389_reproductive_system_phenotype0.66857411
150* MP0000613_abnormal_salivary_gland0.66269381

Predicted human phenotypes

RankGene SetZ-score
1Irregular epiphyses (HP:0010582)3.72039788
2Birth length less than 3rd percentile (HP:0003561)3.47549241
3Delayed epiphyseal ossification (HP:0002663)3.34988272
4Premature rupture of membranes (HP:0001788)3.18217786
5Hyperinsulinemic hypoglycemia (HP:0000825)3.17735900
6Type I transferrin isoform profile (HP:0003642)3.14671947
7Hypoglycemic coma (HP:0001325)3.13046992
8Hypoglycemic seizures (HP:0002173)3.10043097
9Small epiphyses (HP:0010585)3.09075612
10Abnormality of aromatic amino acid family metabolism (HP:0004338)3.06190940
11Abnormality of the intrinsic pathway (HP:0010989)2.97616022
12Hypobetalipoproteinemia (HP:0003563)2.92521353
13Flat capital femoral epiphysis (HP:0003370)2.89152006
14Hypolipoproteinemia (HP:0010981)2.87399634
15Carpal bone hypoplasia (HP:0001498)2.83527831
16Symptomatic seizures (HP:0011145)2.82750204
17Epiphyseal dysplasia (HP:0002656)2.77872396
18Rough bone trabeculation (HP:0100670)2.75281435
19Hyperglycinemia (HP:0002154)2.71796968
20Intrahepatic cholestasis (HP:0001406)2.70166966
21Abnormal protein glycosylation (HP:0012346)2.69813132
22Abnormal glycosylation (HP:0012345)2.69813132
23Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.69813132
24Abnormal protein N-linked glycosylation (HP:0012347)2.69813132
25Abnormality of the anterior horn cell (HP:0006802)2.69547473
26Degeneration of anterior horn cells (HP:0002398)2.69547473
27Abnormal tarsal ossification (HP:0008369)2.69034321
28Increased serum pyruvate (HP:0003542)2.68300983
29Abnormality of glycolysis (HP:0004366)2.68300983
30Reduced antithrombin III activity (HP:0001976)2.66580363
31Follicular hyperkeratosis (HP:0007502)2.65652767
32Genu varum (HP:0002970)2.63079021
33Breast hypoplasia (HP:0003187)2.62581866
34Soft skin (HP:0000977)2.57329256
35Hyperglycemia (HP:0003074)2.51065804
36Irregular vertebral endplates (HP:0003301)2.48536143
37Abnormal pancreas size (HP:0012094)2.43585888
38Cerebral hypomyelination (HP:0006808)2.40807477
39Bifid tongue (HP:0010297)2.38574597
40Megaloblastic anemia (HP:0001889)2.37409435
41Metaphyseal cupping (HP:0003021)2.35917135
42Aortic dissection (HP:0002647)2.34922558
43Generalized aminoaciduria (HP:0002909)2.33341072
44Abnormality of serum amino acid levels (HP:0003112)2.27998251
45Aplastic anemia (HP:0001915)2.27176895
46Beaking of vertebral bodies (HP:0004568)2.26741912
47Proximal tubulopathy (HP:0000114)2.25343142
48Abnormality of monocarboxylic acid metabolism (HP:0010996)2.24909128
49Abnormal trabecular bone morphology (HP:0100671)2.24567438
50Abnormality of methionine metabolism (HP:0010901)2.23819070
51Abnormality of the vertebral endplates (HP:0005106)2.21444166
52Secondary amenorrhea (HP:0000869)2.18761450
53Cardiovascular calcification (HP:0011915)2.17197301
54Hepatic necrosis (HP:0002605)2.16222051
55Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.14548402
56Metaphyseal dysplasia (HP:0100255)2.13908576
57Glycosuria (HP:0003076)2.12694717
58Abnormality of urine glucose concentration (HP:0011016)2.12694717
59Ependymoma (HP:0002888)2.11538160
60Delayed gross motor development (HP:0002194)2.11317835
61Intestinal atresia (HP:0011100)2.10225177
62Fat malabsorption (HP:0002630)2.07926393
63Hyperglycinuria (HP:0003108)2.07438790
64Abnormality of aspartate family amino acid metabolism (HP:0010899)2.06825517
65Abnormality of dentin (HP:0010299)2.06645482
66Volvulus (HP:0002580)2.06401941
67Abnormal foot bone ossification (HP:0010675)2.05545992
68Absent epiphyses (HP:0010577)2.05345064
69Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.05345064
70Aplasia/hypoplasia of the uterus (HP:0008684)2.05066426
71Gout (HP:0001997)2.04547129
72Oral leukoplakia (HP:0002745)2.03966688
73Abnormality of glycine metabolism (HP:0010895)2.03198536
74Abnormality of serine family amino acid metabolism (HP:0010894)2.03198536
7511 pairs of ribs (HP:0000878)2.02419946
76Vascular tortuosity (HP:0004948)2.02147423
77Abnormal biliary tract morphology (HP:0012440)2.02102060
78Hypoalphalipoproteinemia (HP:0003233)2.00218958
79Abnormality of the labia minora (HP:0012880)1.99561996
80Abnormality of sulfur amino acid metabolism (HP:0004339)1.98457518
81Acute encephalopathy (HP:0006846)1.98085233
82Arterial tortuosity (HP:0005116)1.97271723
83Vitreoretinal degeneration (HP:0000655)1.96278873
84Abnormal cartilage morphology (HP:0002763)1.93875411
85Conjugated hyperbilirubinemia (HP:0002908)1.93675148
86Metaphyseal irregularity (HP:0003025)1.92841118
87Hypothermia (HP:0002045)1.92731842
88Prolonged partial thromboplastin time (HP:0003645)1.92455940
89Methylmalonic acidemia (HP:0002912)1.91640654
90Abnormal hemoglobin (HP:0011902)1.88094531
91Abnormal umbilical cord blood vessels (HP:0011403)1.88069248
92Single umbilical artery (HP:0001195)1.88069248
93Abnormality of the fetal cardiovascular system (HP:0010948)1.88069248
94Aplasia/Hypoplasia involving the musculature (HP:0001460)1.88007465
95Patchy hypopigmentation of hair (HP:0011365)1.87843644
96Acute necrotizing encephalopathy (HP:0006965)1.86797422
97Vascular calcification (HP:0004934)1.86523158
98Enlarged epiphyses (HP:0010580)1.85245646
99Abnormal lung lobation (HP:0002101)1.84374857
100Abnormality of the astrocytes (HP:0100707)1.83938729
101Astrocytoma (HP:0009592)1.83938729
102Lethargy (HP:0001254)1.83137493
103Increased CSF lactate (HP:0002490)1.82925405
104Stillbirth (HP:0003826)1.82447913
105Decreased muscle mass (HP:0003199)1.82102303
106Platyspondyly (HP:0000926)1.80658701
107Microvesicular hepatic steatosis (HP:0001414)1.79603442
108Insulin-resistant diabetes mellitus (HP:0000831)1.79581334
109Mitochondrial inheritance (HP:0001427)1.79250072
110Abnormal delivery (HP:0001787)1.78821019
111Abnormality of femoral epiphyses (HP:0006499)1.78409048
112Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.78409048
113Pancreatic islet-cell hyperplasia (HP:0004510)1.78294690
114Abnormality of the femoral head (HP:0003368)1.78264166
115Increased serum lactate (HP:0002151)1.78089075
116Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.77847895
117Prominent metopic ridge (HP:0005487)1.77818003
118Abnormal epiphyseal ossification (HP:0010656)1.77794431
119Meckel diverticulum (HP:0002245)1.77793936
120Stenosis of the external auditory canal (HP:0000402)1.77587200
121Abnormality of the common coagulation pathway (HP:0010990)1.77490997
122Cervical subluxation (HP:0003308)1.77434340
123CNS demyelination (HP:0007305)1.77338251
124Steatorrhea (HP:0002570)1.77328844
125Hepatocellular necrosis (HP:0001404)1.76752368
126Cupped ribs (HP:0000887)1.76388536
127Colon cancer (HP:0003003)1.76051060
128Abnormality of the epiphysis of the femoral head (HP:0010574)1.75371322
129Adrenal hypoplasia (HP:0000835)1.75175964
130Increased corneal curvature (HP:0100692)1.74700323
131Keratoconus (HP:0000563)1.74700323
132Cerebral edema (HP:0002181)1.73929083
133Abnormality of vitamin B metabolism (HP:0004340)1.73213822
134Glioma (HP:0009733)1.72977130
135Microretrognathia (HP:0000308)1.72647235
136Biconcave vertebral bodies (HP:0004586)1.72414351
137Protuberant abdomen (HP:0001538)1.72286151
138Spontaneous abortion (HP:0005268)1.70115457
139Chronic hepatic failure (HP:0100626)1.68722008
140Hypoplastic labia majora (HP:0000059)1.67283372
141Labial hypoplasia (HP:0000066)1.67024035
142Abnormality of the ileum (HP:0001549)1.66815873
143Chromsome breakage (HP:0040012)1.66376638
144Rhabdomyosarcoma (HP:0002859)1.64735371
145Supernumerary spleens (HP:0009799)1.63870439
146Hypoplastic female external genitalia (HP:0012815)1.61594580
147Abnormality of vitamin metabolism (HP:0100508)1.61118892
148Hypoplastic pelvis (HP:0008839)1.61086405
149Mitral stenosis (HP:0001718)1.60404578
150Chorioretinal atrophy (HP:0000533)1.59701252
151Papillary thyroid carcinoma (HP:0002895)1.58298097
152Abnormality of chromosome stability (HP:0003220)1.58130564
153Aplasia/Hypoplasia of the uvula (HP:0010293)1.57857112
154Pulmonic stenosis (HP:0001642)1.57389733
155Renal cortical cysts (HP:0000803)1.56600418
156Aplasia/Hypoplasia of the tibia (HP:0005772)1.56412692
157Disproportionate short-trunk short stature (HP:0003521)1.55992599
158Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.53653150
159Abnormality of alanine metabolism (HP:0010916)1.53653150
160Hyperalaninemia (HP:0003348)1.53653150
161Short tibia (HP:0005736)1.53642949
162Chromosomal breakage induced by crosslinking agents (HP:0003221)1.52462203
163Abnormality of the vitamin B12 metabolism (HP:0004341)1.51678822
164Protrusio acetabuli (HP:0003179)1.48554373
165Abnormality of the labia majora (HP:0012881)1.47071178
166Abnormality of the duodenum (HP:0002246)1.46649247
167Abnormality of the pancreatic islet cells (HP:0006476)1.46490877
168Abnormality of endocrine pancreas physiology (HP:0012093)1.46490877
169Gonadotropin excess (HP:0000837)1.45479553
170Small hand (HP:0200055)1.45382547
171Genital tract atresia (HP:0001827)1.44696962
172Curly hair (HP:0002212)1.42283889
173Abnormality of the umbilical cord (HP:0010881)1.42181511

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.17491803
2EIF2AK13.53487445
3EIF2AK33.40516884
4STK163.11687845
5TRIM282.98835826
6PASK2.94178675
7BRSK22.89649697
8BCKDK2.82793246
9WEE12.62964330
10FRK2.45771651
11NME22.24873651
12ACVR1B2.18506842
13STK38L2.01968333
14PNCK1.98569596
15EPHA21.97611948
16PLK41.94723978
17AKT31.91872226
18CASK1.90743494
19TNIK1.83349649
20TESK21.83150296
21VRK11.80387766
22TSSK61.80087430
23IRAK31.74522391
24MAPK151.73913130
25SRPK11.64233877
26STK391.59176073
27PLK31.56464275
28PBK1.55187681
29NME11.46044115
30INSRR1.43594041
31MKNK11.43581408
32BCR1.39336732
33DYRK31.34037031
34NUAK11.30523831
35DYRK21.29207365
36BRSK11.25809159
37PLK11.25305212
38TLK11.22631063
39FGFR21.20776738
40MST41.20201700
41MYLK1.19922597
42TTK1.18836677
43EIF2AK21.17936741
44NEK21.16908746
45MAP3K121.16060635
46LIMK11.15715894
47BMPR1B1.12565212
48MET1.10503327
49WNK31.07231651
50MKNK21.04830438
51FGFR11.04273764
52ZAK1.04228004
53CDC71.04083586
54FLT31.03285599
55AURKB1.02896136
56TAOK30.98715513
57AURKA0.96592952
58CDK80.96376998
59GRK10.95561704
60TESK10.94958950
61SCYL20.94633354
62MAP3K40.92337103
63PIK3CG0.88642497
64MAP4K20.87045430
65PRKCE0.86299662
66RPS6KA40.85740798
67ATR0.82394535
68RPS6KB20.82123890
69PTK20.81642418
70MAP3K30.77493426
71PRKCI0.77250113
72BRD40.73532211
73PIM20.73219953
74CDK70.73185273
75LATS10.71223508
76IRAK40.69984389
77PDGFRA0.69477645
78SIK30.67064133
79WNK40.62366052
80PAK40.61033833
81CSNK2A20.60105754
82CSNK2A10.59720315
83KSR10.59600262
84BRAF0.59318442
85PDK20.57838804
86CAMK1G0.57556543
87CHEK10.57246488
88CHEK20.57049380
89TIE10.56980636
90ROCK10.56166322
91ERBB40.55754109
92LATS20.55749545
93ABL20.54383537
94STK30.53263026
95NEK90.50886781
96PDK40.50636977
97PDK30.50636977
98DMPK0.49145007
99TGFBR20.48488421
100CCNB10.46944113
101STK240.46882184
102MAPKAPK50.46631805
103EPHB20.46317844
104FER0.44444521
105TEC0.42788282
106MELK0.42597688
107CSNK1G30.42551525
108ATM0.42519078
109NEK10.42481980
110CSNK1A1L0.42075131
111CSNK1G20.41869490
112ERBB30.41630113
113MAP3K80.41550440
114OXSR10.40919322
115YES10.40901740
116NEK60.40900791
117PAK20.40820459
118TAF10.40519806
119PRKCG0.39638452
120CLK10.39426894
121ILK0.38655115
122KDR0.37715122
123ROCK20.37519788
124ERN10.37328461
125GSK3A0.37291321
126NLK0.37078349
127CSNK1E0.36917158
128CSNK1G10.36496333
129TGFBR10.36135964
130ADRBK20.35666796
131PLK20.35376462
132PAK10.34078516
133PAK30.33022605
134RPS6KA50.32847034
135LMTK20.31732741
136DDR20.31490007
137MINK10.30988928
138MAP2K70.29909157
139CDK20.29816964

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030604.26592497
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.38744013
3Proteasome_Homo sapiens_hsa030503.25868726
4RNA polymerase_Homo sapiens_hsa030203.21489016
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.59320557
6Mismatch repair_Homo sapiens_hsa034302.21739805
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.21689484
8Folate biosynthesis_Homo sapiens_hsa007902.18668998
9* Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.10339747
10Pyrimidine metabolism_Homo sapiens_hsa002402.00853316
11Ribosome_Homo sapiens_hsa030101.99776144
12One carbon pool by folate_Homo sapiens_hsa006701.97384890
13DNA replication_Homo sapiens_hsa030301.96712718
14Sulfur metabolism_Homo sapiens_hsa009201.96021588
15Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.94807473
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.88105271
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.87909336
18RNA transport_Homo sapiens_hsa030131.85126931
19Selenocompound metabolism_Homo sapiens_hsa004501.80020838
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.77302551
21Nucleotide excision repair_Homo sapiens_hsa034201.72008917
22Steroid biosynthesis_Homo sapiens_hsa001001.63073267
23Spliceosome_Homo sapiens_hsa030401.52366090
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.47234778
25Vitamin B6 metabolism_Homo sapiens_hsa007501.46372570
26Homologous recombination_Homo sapiens_hsa034401.46086275
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.42587090
28Basal transcription factors_Homo sapiens_hsa030221.40548906
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.33214801
30Base excision repair_Homo sapiens_hsa034101.27748097
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.24840098
32Fatty acid elongation_Homo sapiens_hsa000621.24769506
33Caffeine metabolism_Homo sapiens_hsa002321.24548318
34Drug metabolism - other enzymes_Homo sapiens_hsa009831.23744430
35N-Glycan biosynthesis_Homo sapiens_hsa005101.21893014
36Cell cycle_Homo sapiens_hsa041101.19147153
37TGF-beta signaling pathway_Homo sapiens_hsa043501.13515606
38Butanoate metabolism_Homo sapiens_hsa006501.12835034
39Purine metabolism_Homo sapiens_hsa002301.10254877
40Other glycan degradation_Homo sapiens_hsa005111.06504641
41Tryptophan metabolism_Homo sapiens_hsa003801.05755202
42Retinol metabolism_Homo sapiens_hsa008301.05006392
43Arginine and proline metabolism_Homo sapiens_hsa003301.03938713
44Peroxisome_Homo sapiens_hsa041461.01017612
45Fanconi anemia pathway_Homo sapiens_hsa034601.00722328
46Oxidative phosphorylation_Homo sapiens_hsa001900.99419035
47Steroid hormone biosynthesis_Homo sapiens_hsa001400.98838816
48Biosynthesis of amino acids_Homo sapiens_hsa012300.96628272
49Vibrio cholerae infection_Homo sapiens_hsa051100.96191198
50Non-homologous end-joining_Homo sapiens_hsa034500.95964144
51Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.94523260
52Glutathione metabolism_Homo sapiens_hsa004800.93482904
53Primary bile acid biosynthesis_Homo sapiens_hsa001200.93331023
54Cysteine and methionine metabolism_Homo sapiens_hsa002700.93127901
55RNA degradation_Homo sapiens_hsa030180.92772555
56Vitamin digestion and absorption_Homo sapiens_hsa049770.92152084
57p53 signaling pathway_Homo sapiens_hsa041150.90948935
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.90044015
59ECM-receptor interaction_Homo sapiens_hsa045120.89563708
60Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.89344928
61Pentose phosphate pathway_Homo sapiens_hsa000300.88792030
62Fructose and mannose metabolism_Homo sapiens_hsa000510.84735907
63Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.80834234
64Galactose metabolism_Homo sapiens_hsa000520.80336483
65Hippo signaling pathway_Homo sapiens_hsa043900.80113135
66Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.78304956
67Arginine biosynthesis_Homo sapiens_hsa002200.77622111
68Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.77406842
69Pentose and glucuronate interconversions_Homo sapiens_hsa000400.77366210
70* Metabolic pathways_Homo sapiens_hsa011000.75768019
71Carbon metabolism_Homo sapiens_hsa012000.75038468
72Pyruvate metabolism_Homo sapiens_hsa006200.73075883
73Sulfur relay system_Homo sapiens_hsa041220.72420972
742-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.70553064
75Histidine metabolism_Homo sapiens_hsa003400.69911768
76Adherens junction_Homo sapiens_hsa045200.69392787
77Nitrogen metabolism_Homo sapiens_hsa009100.68434707
78Regulation of autophagy_Homo sapiens_hsa041400.67507122
79Fat digestion and absorption_Homo sapiens_hsa049750.67051200
80Propanoate metabolism_Homo sapiens_hsa006400.66742915
81Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.66468419
82Lysine degradation_Homo sapiens_hsa003100.66334387
83Circadian rhythm_Homo sapiens_hsa047100.66187067
84PPAR signaling pathway_Homo sapiens_hsa033200.65480010
85Huntingtons disease_Homo sapiens_hsa050160.65312033
86Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.64962734
87Parkinsons disease_Homo sapiens_hsa050120.64552997
88Tight junction_Homo sapiens_hsa045300.63633075
89Fatty acid degradation_Homo sapiens_hsa000710.62742046
90beta-Alanine metabolism_Homo sapiens_hsa004100.61634741
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61296806
92Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60852652
93Phenylalanine metabolism_Homo sapiens_hsa003600.58575260
94Epstein-Barr virus infection_Homo sapiens_hsa051690.57961064
95Hedgehog signaling pathway_Homo sapiens_hsa043400.54937100
96Arachidonic acid metabolism_Homo sapiens_hsa005900.54003054
97Tyrosine metabolism_Homo sapiens_hsa003500.53667804
98Antigen processing and presentation_Homo sapiens_hsa046120.53575093
99Mineral absorption_Homo sapiens_hsa049780.53529757
100Sphingolipid metabolism_Homo sapiens_hsa006000.50114864
101Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.48958188
102mRNA surveillance pathway_Homo sapiens_hsa030150.48351812
103Oocyte meiosis_Homo sapiens_hsa041140.47525418
104Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.47368160
105Starch and sucrose metabolism_Homo sapiens_hsa005000.47178386
106Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45821848
107Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.45641300
108Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.45008057
109Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43497188
110Cyanoamino acid metabolism_Homo sapiens_hsa004600.42476245
111Renin-angiotensin system_Homo sapiens_hsa046140.42144982
112Complement and coagulation cascades_Homo sapiens_hsa046100.41671142
113Ether lipid metabolism_Homo sapiens_hsa005650.41386502
114Basal cell carcinoma_Homo sapiens_hsa052170.40868681
115Glycerolipid metabolism_Homo sapiens_hsa005610.40742850
116Fatty acid biosynthesis_Homo sapiens_hsa000610.40662468
117Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40465571
118Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.40230613
119Fatty acid metabolism_Homo sapiens_hsa012120.39527262
120Chemical carcinogenesis_Homo sapiens_hsa052040.39466148
121Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38908978
122Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.36715669
123Legionellosis_Homo sapiens_hsa051340.36447883
124Linoleic acid metabolism_Homo sapiens_hsa005910.35508713
125Lysosome_Homo sapiens_hsa041420.35493198
126Protein digestion and absorption_Homo sapiens_hsa049740.33621071
127Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.33597216

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