PGM2L1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)6.37954903
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.04672318
3synaptic vesicle exocytosis (GO:0016079)5.77511810
4glutamate secretion (GO:0014047)5.68240903
5vocalization behavior (GO:0071625)5.63576307
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.51415758
7synaptic vesicle maturation (GO:0016188)5.47423712
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.39756796
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.39575022
10locomotory exploration behavior (GO:0035641)5.38060029
11protein localization to synapse (GO:0035418)5.24040324
12neuron cell-cell adhesion (GO:0007158)5.21361923
13synaptic vesicle docking involved in exocytosis (GO:0016081)5.16833194
14regulation of synaptic vesicle exocytosis (GO:2000300)5.14378731
15nucleobase catabolic process (GO:0046113)5.12718222
16regulation of glutamate receptor signaling pathway (GO:1900449)4.98036199
17ionotropic glutamate receptor signaling pathway (GO:0035235)4.77574966
18exploration behavior (GO:0035640)4.63511401
19regulation of synaptic vesicle transport (GO:1902803)4.58230300
20regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.55745732
21glutamate receptor signaling pathway (GO:0007215)4.49135767
22neuronal action potential propagation (GO:0019227)4.43206041
23regulation of long-term neuronal synaptic plasticity (GO:0048169)4.37713610
24layer formation in cerebral cortex (GO:0021819)4.35512195
25synaptic transmission, glutamatergic (GO:0035249)4.30215745
26neurotransmitter secretion (GO:0007269)4.28106365
27proline transport (GO:0015824)4.19909679
28neuron-neuron synaptic transmission (GO:0007270)4.18855126
29neurotransmitter-gated ion channel clustering (GO:0072578)4.18203388
30regulation of neuronal synaptic plasticity (GO:0048168)4.17777063
31neuron recognition (GO:0008038)4.06281187
32behavioral response to nicotine (GO:0035095)3.98060176
33positive regulation of synapse maturation (GO:0090129)3.95997358
34presynaptic membrane assembly (GO:0097105)3.95757382
35postsynaptic membrane organization (GO:0001941)3.93087999
36regulation of excitatory postsynaptic membrane potential (GO:0060079)3.93081507
37negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.91382950
38neurofilament cytoskeleton organization (GO:0060052)3.90778972
39dendritic spine morphogenesis (GO:0060997)3.89994123
40regulation of synapse structural plasticity (GO:0051823)3.88393140
41regulation of postsynaptic membrane potential (GO:0060078)3.80874711
42gamma-aminobutyric acid signaling pathway (GO:0007214)3.79353109
43long-term memory (GO:0007616)3.78964190
44axonal fasciculation (GO:0007413)3.72611414
45positive regulation of membrane potential (GO:0045838)3.68066500
46establishment of mitochondrion localization (GO:0051654)3.66677593
47positive regulation of synapse assembly (GO:0051965)3.62643090
48synaptic vesicle endocytosis (GO:0048488)3.61900580
49regulation of synaptic plasticity (GO:0048167)3.61893390
50negative regulation of synaptic transmission, GABAergic (GO:0032229)3.59154325
51long-term synaptic potentiation (GO:0060291)3.56786316
52response to histamine (GO:0034776)3.55660149
53presynaptic membrane organization (GO:0097090)3.54092087
54regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.53007503
55gamma-aminobutyric acid transport (GO:0015812)3.52347019
56regulation of neurotransmitter secretion (GO:0046928)3.51651629
57positive regulation of neurotransmitter secretion (GO:0001956)3.50416419
58neurotransmitter transport (GO:0006836)3.49661324
59regulation of dendritic spine morphogenesis (GO:0061001)3.49577877
60G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.46758265
61positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.45442926
62cellular potassium ion homeostasis (GO:0030007)3.45147733
63neuronal action potential (GO:0019228)3.42637494
64activation of protein kinase A activity (GO:0034199)3.42247986
65innervation (GO:0060384)3.40286441
66regulation of synaptic transmission, glutamatergic (GO:0051966)3.36587354
67behavioral defense response (GO:0002209)3.34229140
68behavioral fear response (GO:0001662)3.34229140
69regulation of vesicle fusion (GO:0031338)3.33670418
70membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.29510501
71cerebellar Purkinje cell differentiation (GO:0021702)3.29113934
72dendrite morphogenesis (GO:0048813)3.26019031
73cerebellar granule cell differentiation (GO:0021707)3.25580510
74G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.23112319
75regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.22429148
76transmission of nerve impulse (GO:0019226)3.21917375
77mechanosensory behavior (GO:0007638)3.21256946
78synapse assembly (GO:0007416)3.21200975
79fear response (GO:0042596)3.19992702
80vesicle transport along microtubule (GO:0047496)3.18932029
81regulation of neurotransmitter levels (GO:0001505)3.18010413
82membrane depolarization (GO:0051899)3.16650950
83cell migration in hindbrain (GO:0021535)3.15464492
84positive regulation of neurotransmitter transport (GO:0051590)3.13867958
85positive regulation of synaptic transmission, GABAergic (GO:0032230)3.13632342
86regulation of dendritic spine development (GO:0060998)3.13501590
87regulation of neurotransmitter transport (GO:0051588)3.13488774
88positive regulation of action potential (GO:0045760)3.13481259
89learning (GO:0007612)3.12406029
90positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.11846858
91mitochondrion transport along microtubule (GO:0047497)3.07231236
92establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.07231236
93regulation of synapse maturation (GO:0090128)3.06884500
94organelle transport along microtubule (GO:0072384)3.06433248
95central nervous system projection neuron axonogenesis (GO:0021952)3.04946614
96social behavior (GO:0035176)3.02264608
97intraspecies interaction between organisms (GO:0051703)3.02264608
98auditory behavior (GO:0031223)3.01185214
99synaptic transmission (GO:0007268)3.00828643
100membrane depolarization during action potential (GO:0086010)3.00005688
101regulation of synaptic transmission (GO:0050804)2.99316160
102neuromuscular process controlling balance (GO:0050885)2.99255519
103serotonin metabolic process (GO:0042428)2.99036811
104synapse organization (GO:0050808)2.97811136
105positive regulation of synaptic transmission (GO:0050806)2.97257594
106startle response (GO:0001964)2.94915101
107neuromuscular synaptic transmission (GO:0007274)2.94823176
108axon extension (GO:0048675)2.94289431
109response to auditory stimulus (GO:0010996)2.93673481
110positive regulation of dendritic spine morphogenesis (GO:0061003)2.93257547
111negative regulation of dendrite morphogenesis (GO:0050774)2.92810985
112long term synaptic depression (GO:0060292)2.92798401
113positive regulation of microtubule polymerization or depolymerization (GO:0031112)2.92708610
114regulation of synapse assembly (GO:0051963)2.90242899
115dendritic spine organization (GO:0097061)2.89727387
116establishment of synaptic vesicle localization (GO:0097480)2.89628819
117synaptic vesicle transport (GO:0048489)2.89628819
118positive regulation of dendritic spine development (GO:0060999)2.89555751
119epithelial cell differentiation involved in kidney development (GO:0035850)2.86523196
120central nervous system neuron axonogenesis (GO:0021955)2.83929875
121heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.79479445
122regulation of action potential (GO:0098900)2.79000923
123behavioral response to ethanol (GO:0048149)2.78856794
124glycosphingolipid biosynthetic process (GO:0006688)2.78611534
125positive regulation of vesicle fusion (GO:0031340)2.78350308
126regulation of synaptic transmission, GABAergic (GO:0032228)2.78012887
127neuronal ion channel clustering (GO:0045161)2.77344896
128adult behavior (GO:0030534)2.77160280
129dendrite development (GO:0016358)2.77036792
130adult walking behavior (GO:0007628)2.76726188
131negative regulation of microtubule polymerization (GO:0031115)2.75957612
132protein localization to cilium (GO:0061512)2.74226768
133behavioral response to cocaine (GO:0048148)2.72862457
134retinal ganglion cell axon guidance (GO:0031290)2.71040077
135adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.70380993
136regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.69813461

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.33257499
2GBX2_23144817_ChIP-Seq_PC3_Human4.01510134
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.13100363
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.06996792
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.97572368
6REST_21632747_ChIP-Seq_MESCs_Mouse2.69125442
7SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.61293019
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.57487992
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.57487992
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.47313711
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.45686498
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.43503139
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.41425153
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.38896542
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.37752154
16RARB_27405468_Chip-Seq_BRAIN_Mouse2.32744792
17DROSHA_22980978_ChIP-Seq_HELA_Human2.22789480
18TAF15_26573619_Chip-Seq_HEK293_Human2.19150783
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.17263420
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.16266060
21CTBP2_25329375_ChIP-Seq_LNCAP_Human2.14259757
22REST_18959480_ChIP-ChIP_MESCs_Mouse2.11252802
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.08385855
24SUZ12_27294783_Chip-Seq_ESCs_Mouse2.06859448
25EZH2_27294783_Chip-Seq_ESCs_Mouse2.06120046
26AR_21572438_ChIP-Seq_LNCaP_Human2.04160942
27CTBP1_25329375_ChIP-Seq_LNCAP_Human2.03644639
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.03333595
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.93476146
30IKZF1_21737484_ChIP-ChIP_HCT116_Human1.88683181
31SMAD4_21799915_ChIP-Seq_A2780_Human1.86347030
32CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.84757092
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.83315406
34ZFP57_27257070_Chip-Seq_ESCs_Mouse1.79829746
35P300_19829295_ChIP-Seq_ESCs_Human1.66945202
36ZNF274_21170338_ChIP-Seq_K562_Hela1.60272587
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.59704377
38HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.59507959
39MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.57571604
40SMAD_19615063_ChIP-ChIP_OVARY_Human1.54365628
41NR3C1_23031785_ChIP-Seq_PC12_Mouse1.48748240
42* EWS_26573619_Chip-Seq_HEK293_Human1.48711998
43SALL1_21062744_ChIP-ChIP_HESCs_Human1.47165949
44SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46862489
45* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.46601046
46AR_25329375_ChIP-Seq_VCAP_Human1.46521261
47POU3F2_20337985_ChIP-ChIP_501MEL_Human1.46479327
48EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44311384
49TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43995373
50SMAD3_21741376_ChIP-Seq_EPCs_Human1.42577941
51SOX2_21211035_ChIP-Seq_LN229_Gbm1.42393377
52TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42072650
53FUS_26573619_Chip-Seq_HEK293_Human1.40756278
54OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37396077
55GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36453123
56FLI1_27457419_Chip-Seq_LIVER_Mouse1.36239498
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.33902910
58IGF1R_20145208_ChIP-Seq_DFB_Human1.33623519
59STAT3_23295773_ChIP-Seq_U87_Human1.32223203
60CBX2_27304074_Chip-Seq_ESCs_Mouse1.31781250
61* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.31531902
62ERG_21242973_ChIP-ChIP_JURKAT_Human1.28778205
63SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28606394
64RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.25874347
65AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.25802909
66ARNT_22903824_ChIP-Seq_MCF-7_Human1.25201156
67PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.23398157
68KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.22166541
69CDX2_19796622_ChIP-Seq_MESCs_Mouse1.21855852
70AR_19668381_ChIP-Seq_PC3_Human1.20479545
71RING1B_27294783_Chip-Seq_ESCs_Mouse1.20419652
72RNF2_27304074_Chip-Seq_NSC_Mouse1.20126404
73TP53_16413492_ChIP-PET_HCT116_Human1.19874034
74ZNF217_24962896_ChIP-Seq_MCF-7_Human1.19647395
75TCF4_23295773_ChIP-Seq_U87_Human1.18502091
76TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18307366
77AHR_22903824_ChIP-Seq_MCF-7_Human1.18015821
78P53_22127205_ChIP-Seq_FIBROBLAST_Human1.17082624
79YAP1_20516196_ChIP-Seq_MESCs_Mouse1.15522737
80PRDM14_20953172_ChIP-Seq_ESCs_Human1.15279185
81CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.14592514
82MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14250476
83PCGF2_27294783_Chip-Seq_ESCs_Mouse1.14097909
84IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.12760886
85CBP_20019798_ChIP-Seq_JUKART_Human1.12760886
86POU5F1_16153702_ChIP-ChIP_HESCs_Human1.12221601
87RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.11541955
88RBPJ_22232070_ChIP-Seq_NCS_Mouse1.10778033
89RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.10689555
90UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10073442
91LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09752565
92RUNX2_22187159_ChIP-Seq_PCA_Human1.08957556
93STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.08539098
94GATA1_26923725_Chip-Seq_HPCs_Mouse1.07080942
95RING1B_27294783_Chip-Seq_NPCs_Mouse1.06768897
96VDR_22108803_ChIP-Seq_LS180_Human1.05912500
97EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05219879
98TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05056073
99POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05056073
100TAL1_26923725_Chip-Seq_HPCs_Mouse1.05036687
101BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.04898074
102KDM2B_26808549_Chip-Seq_REH_Human1.04361641
103FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.04358472
104JUN_21703547_ChIP-Seq_K562_Human1.03893943
105WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03785522
106CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.02130258
107TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02041121
108ER_23166858_ChIP-Seq_MCF-7_Human1.01397137
109TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01344909
110TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.00635299
111NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99800774
112TP53_18474530_ChIP-ChIP_U2OS_Human0.99396464
113MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98905166
114SMAD3_21741376_ChIP-Seq_ESCs_Human0.98066377
115NANOG_18555785_Chip-Seq_ESCs_Mouse0.97420768
116CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96874089
117BCAT_22108803_ChIP-Seq_LS180_Human0.96443770
118ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.92722218
119* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.91570961
120TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91309356
121SMAD4_21741376_ChIP-Seq_HESCs_Human0.89725017

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.47939977
2MP0003880_abnormal_central_pattern5.20549318
3MP0003635_abnormal_synaptic_transmissio4.22110239
4MP0004270_analgesia4.13672524
5MP0001968_abnormal_touch/_nociception3.49825156
6MP0009745_abnormal_behavioral_response3.44406607
7MP0002063_abnormal_learning/memory/cond3.43882350
8MP0002064_seizures3.13821563
9MP0009046_muscle_twitch2.96746291
10MP0002734_abnormal_mechanical_nocicepti2.95187442
11MP0002572_abnormal_emotion/affect_behav2.90892920
12MP0002735_abnormal_chemical_nociception2.79939543
13MP0002736_abnormal_nociception_after2.75963481
14MP0005423_abnormal_somatic_nervous2.59195680
15MP0002272_abnormal_nervous_system2.50992939
16MP0001486_abnormal_startle_reflex2.41134926
17MP0001440_abnormal_grooming_behavior2.37352499
18MP0002733_abnormal_thermal_nociception2.26932630
19MP0001501_abnormal_sleep_pattern2.23284234
20MP0001970_abnormal_pain_threshold2.13904166
21MP0009780_abnormal_chondrocyte_physiolo2.13115837
22MP0002067_abnormal_sensory_capabilities2.10064040
23MP0000778_abnormal_nervous_system2.08475150
24MP0002184_abnormal_innervation2.02090775
25MP0006276_abnormal_autonomic_nervous2.00755271
26MP0003121_genomic_imprinting1.94892693
27MP0002102_abnormal_ear_morphology1.86492167
28MP0005386_behavior/neurological_phenoty1.85879241
29MP0004924_abnormal_behavior1.85879241
30MP0003329_amyloid_beta_deposits1.83187454
31MP0002557_abnormal_social/conspecific_i1.79242848
32MP0004811_abnormal_neuron_physiology1.79061792
33MP0002822_catalepsy1.77888430
34MP0004858_abnormal_nervous_system1.74552504
35MP0008569_lethality_at_weaning1.74385513
36MP0003879_abnormal_hair_cell1.71456216
37MP0008877_abnormal_DNA_methylation1.68957611
38MP0004133_heterotaxia1.56407097
39MP0002909_abnormal_adrenal_gland1.55561855
40MP0000955_abnormal_spinal_cord1.55249994
41MP0003890_abnormal_embryonic-extraembry1.54307048
42MP0001984_abnormal_olfaction1.52734569
43MP0003787_abnormal_imprinting1.51256140
44MP0002882_abnormal_neuron_morphology1.43458524
45MP0002066_abnormal_motor_capabilities/c1.41150900
46MP0001188_hyperpigmentation1.39964419
47MP0001905_abnormal_dopamine_level1.36963185
48MP0005646_abnormal_pituitary_gland1.36520458
49MP0003633_abnormal_nervous_system1.30595758
50MP0002638_abnormal_pupillary_reflex1.19566489
51MP0004885_abnormal_endolymph1.18960995
52MP0000569_abnormal_digit_pigmentation1.17538462
53MP0001502_abnormal_circadian_rhythm1.16380704
54MP0005645_abnormal_hypothalamus_physiol1.15450769
55MP0002152_abnormal_brain_morphology1.12875851
56MP0004142_abnormal_muscle_tone1.12751686
57MP0002837_dystrophic_cardiac_calcinosis1.12398024
58MP0001529_abnormal_vocalization1.11878240
59MP0003631_nervous_system_phenotype1.11215109
60MP0003119_abnormal_digestive_system1.08577275
61MP0010386_abnormal_urinary_bladder1.08495983
62MP0008872_abnormal_physiological_respon1.03094355
63MP0003122_maternal_imprinting1.01572675
64MP0002234_abnormal_pharynx_morphology0.98998967
65MP0004145_abnormal_muscle_electrophysio0.97935351
66MP0003123_paternal_imprinting0.93363177
67MP0008874_decreased_physiological_sensi0.92781426
68MP0002229_neurodegeneration0.91653428
69MP0001986_abnormal_taste_sensitivity0.90857785
70MP0002069_abnormal_eating/drinking_beha0.90130480
71MP0002876_abnormal_thyroid_physiology0.89999038
72MP0004484_altered_response_of0.88951810
73MP0000751_myopathy0.88003775
74MP0004742_abnormal_vestibular_system0.87704049
75MP0005253_abnormal_eye_physiology0.87448423
76MP0005551_abnormal_eye_electrophysiolog0.86493614
77MP0006072_abnormal_retinal_apoptosis0.85611068
78MP0001963_abnormal_hearing_physiology0.84694465
79MP0000604_amyloidosis0.82347877
80MP0004085_abnormal_heartbeat0.81623422
81MP0005535_abnormal_body_temperature0.81164708
82MP0001299_abnormal_eye_distance/0.80331112
83MP0010234_abnormal_vibrissa_follicle0.79503938
84MP0003283_abnormal_digestive_organ0.78922528
85MP0000631_abnormal_neuroendocrine_gland0.76742236
86MP0005394_taste/olfaction_phenotype0.76225159
87MP0005499_abnormal_olfactory_system0.76225159
88MP0002752_abnormal_somatic_nervous0.76013417
89MP0004147_increased_porphyrin_level0.75989047
90MP0005084_abnormal_gallbladder_morpholo0.73661648
91MP0005195_abnormal_posterior_eye0.73139487
92MP0004215_abnormal_myocardial_fiber0.72664493
93MP0003632_abnormal_nervous_system0.72013156
94MP0005187_abnormal_penis_morphology0.70752967
95MP0001177_atelectasis0.70331091
96MP0003937_abnormal_limbs/digits/tail_de0.69362844
97MP0003567_abnormal_fetal_cardiomyocyte0.69046997
98MP0003938_abnormal_ear_development0.69033700
99MP0000049_abnormal_middle_ear0.68589110
100MP0005409_darkened_coat_color0.68525318
101MP0002081_perinatal_lethality0.68464525
102MP0004510_myositis0.68022638
103MP0003634_abnormal_glial_cell0.66347849
104MP0001664_abnormal_digestion0.65193610
105MP0000566_synostosis0.64683182
106MP0008961_abnormal_basal_metabolism0.64405364
107MP0006292_abnormal_olfactory_placode0.61721285
108MP0003861_abnormal_nervous_system0.61139793
109MP0004233_abnormal_muscle_weight0.59361115
110MP0002090_abnormal_vision0.55516709
111MP0001943_abnormal_respiration0.54553273
112MP0010769_abnormal_survival0.53093447
113MP0010770_preweaning_lethality0.53070723
114MP0002082_postnatal_lethality0.53070723
115MP0003956_abnormal_body_size0.51659424
116MP0003075_altered_response_to0.51244949
117MP0010768_mortality/aging0.49843360
118MP0003137_abnormal_impulse_conducting0.49338171
119MP0000026_abnormal_inner_ear0.47523729
120MP0001485_abnormal_pinna_reflex0.46668994
121MP0000920_abnormal_myelination0.45910088
122MP0000013_abnormal_adipose_tissue0.45609647
123MP0002751_abnormal_autonomic_nervous0.45425641
124MP0000015_abnormal_ear_pigmentation0.45253313

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.97205828
2Myokymia (HP:0002411)6.02489660
3Focal seizures (HP:0007359)6.00387582
4Visual hallucinations (HP:0002367)5.54764683
5Epileptic encephalopathy (HP:0200134)5.53957774
6Atonic seizures (HP:0010819)4.91803625
7Febrile seizures (HP:0002373)4.62709355
8Absence seizures (HP:0002121)4.55511661
9Progressive cerebellar ataxia (HP:0002073)4.43983178
10Hyperventilation (HP:0002883)4.38185871
11Dialeptic seizures (HP:0011146)4.12885801
12Broad-based gait (HP:0002136)4.07405456
13Generalized tonic-clonic seizures (HP:0002069)3.97155660
14Poor eye contact (HP:0000817)3.64620134
15Supranuclear gaze palsy (HP:0000605)3.49243255
16Action tremor (HP:0002345)3.48189524
17Amblyopia (HP:0000646)3.40995164
18Papilledema (HP:0001085)3.40613333
19Drooling (HP:0002307)3.34673009
20Excessive salivation (HP:0003781)3.34673009
21Gaze-evoked nystagmus (HP:0000640)3.33715134
22Mutism (HP:0002300)3.33210813
23Impaired social interactions (HP:0000735)3.17214694
24Abnormal social behavior (HP:0012433)3.17214694
25Urinary bladder sphincter dysfunction (HP:0002839)3.13130578
26Impaired vibration sensation in the lower limbs (HP:0002166)3.12505654
27Truncal ataxia (HP:0002078)3.12431599
28Insidious onset (HP:0003587)3.06971538
29Termporal pattern (HP:0011008)3.06971538
30Depression (HP:0000716)2.94509935
31Ankle clonus (HP:0011448)2.92992021
32Dysdiadochokinesis (HP:0002075)2.91380418
33Genetic anticipation (HP:0003743)2.89408026
34Epileptiform EEG discharges (HP:0011182)2.89060258
35Cerebral inclusion bodies (HP:0100314)2.85311637
36Amyotrophic lateral sclerosis (HP:0007354)2.82856074
37Dysmetria (HP:0001310)2.81896832
38Lissencephaly (HP:0001339)2.81028829
39Abnormality of the corticospinal tract (HP:0002492)2.80500623
40Progressive inability to walk (HP:0002505)2.78843840
41Absent speech (HP:0001344)2.77858552
42Inability to walk (HP:0002540)2.77200371
43Hypothermia (HP:0002045)2.74934775
44Abnormality of binocular vision (HP:0011514)2.74247342
45Diplopia (HP:0000651)2.74247342
46Abnormal eating behavior (HP:0100738)2.69789894
47EEG with generalized epileptiform discharges (HP:0011198)2.69774738
48Urinary urgency (HP:0000012)2.69523866
49Impaired smooth pursuit (HP:0007772)2.66985110
50Anxiety (HP:0000739)2.66551557
51Inappropriate behavior (HP:0000719)2.63205236
52Stereotypic behavior (HP:0000733)2.62323950
53Postural instability (HP:0002172)2.62036013
54Abnormality of the labia minora (HP:0012880)2.56757465
55Protruding tongue (HP:0010808)2.56601306
56Abnormality of the lower motor neuron (HP:0002366)2.55009897
57Fetal akinesia sequence (HP:0001989)2.54433199
58Limb dystonia (HP:0002451)2.52651481
59Hypsarrhythmia (HP:0002521)2.50575615
60Neurofibrillary tangles (HP:0002185)2.47648646
61Pachygyria (HP:0001302)2.43954212
62Bradykinesia (HP:0002067)2.42404550
63Polyphagia (HP:0002591)2.41079957
64Nephronophthisis (HP:0000090)2.39206169
65Scanning speech (HP:0002168)2.37067803
66Medial flaring of the eyebrow (HP:0010747)2.35120398
67Spastic gait (HP:0002064)2.35009578
68Akinesia (HP:0002304)2.33723588
69Hemiparesis (HP:0001269)2.33169687
70Morphological abnormality of the pyramidal tract (HP:0002062)2.32660787
71Abnormality of midbrain morphology (HP:0002418)2.31548867
72Molar tooth sign on MRI (HP:0002419)2.31548867
73Status epilepticus (HP:0002133)2.31140857
74Cortical dysplasia (HP:0002539)2.30166442
75Abnormality of ocular smooth pursuit (HP:0000617)2.28318854
76Generalized myoclonic seizures (HP:0002123)2.24916246
77Pheochromocytoma (HP:0002666)2.23698006
78Abnormality of salivation (HP:0100755)2.22087184
79Agitation (HP:0000713)2.19977993
80Spastic tetraplegia (HP:0002510)2.19342084
81Torticollis (HP:0000473)2.19095663
82Abnormal respiratory epithelium morphology (HP:0012253)2.17027485
83Abnormal respiratory motile cilium morphology (HP:0005938)2.17027485
84Dysmetric saccades (HP:0000641)2.16432039
85Pancreatic fibrosis (HP:0100732)2.14948578
86Congenital primary aphakia (HP:0007707)2.14738961
87Blue irides (HP:0000635)2.14678167
88Impaired vibratory sensation (HP:0002495)2.14426173
89Specific learning disability (HP:0001328)2.12736781
90Poor suck (HP:0002033)2.10347232
91Generalized hypopigmentation of hair (HP:0011358)2.10075309
92Ulnar claw (HP:0001178)2.09723017
93Hyperthyroidism (HP:0000836)2.09473946
94Obstructive sleep apnea (HP:0002870)2.09206931
95Pancreatic cysts (HP:0001737)2.08842524
96Genital tract atresia (HP:0001827)2.08747520
97Focal dystonia (HP:0004373)2.06913111
98Vaginal atresia (HP:0000148)2.04724500
99Intention tremor (HP:0002080)2.04461541
100True hermaphroditism (HP:0010459)2.04433289
101Nephrogenic diabetes insipidus (HP:0009806)2.04206430
102Gait imbalance (HP:0002141)2.02623530
103Lower limb muscle weakness (HP:0007340)2.02332437
104Muscular hypotonia of the trunk (HP:0008936)1.96480449
105Megalencephaly (HP:0001355)1.96432299
106Sleep apnea (HP:0010535)1.96429129
107Aqueductal stenosis (HP:0002410)1.95247090
108Gait ataxia (HP:0002066)1.94569704
109Neuroendocrine neoplasm (HP:0100634)1.92487829
110Fair hair (HP:0002286)1.92169255
111Esotropia (HP:0000565)1.91553640
112Exotropia (HP:0000577)1.89615285
113Delusions (HP:0000746)1.87966569
114Incomplete penetrance (HP:0003829)1.86867651
115Aplasia/Hypoplasia of the brainstem (HP:0007362)1.85461405
116Hypoplasia of the brainstem (HP:0002365)1.85461405
117Dynein arm defect of respiratory motile cilia (HP:0012255)1.84899182
118Absent/shortened dynein arms (HP:0200106)1.84899182
119Degeneration of the lateral corticospinal tracts (HP:0002314)1.84064000
120Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.84064000
121Widely spaced teeth (HP:0000687)1.83724097
122Abnormality of the renal medulla (HP:0100957)1.82969152
123Volvulus (HP:0002580)1.82916618
124Psychosis (HP:0000709)1.80955210
125Craniofacial dystonia (HP:0012179)1.80201301
126Hemiplegia (HP:0002301)1.79254365
127Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.78824211
128Hypoventilation (HP:0002791)1.76890071
129Lower limb amyotrophy (HP:0007210)1.76662605
130Apathy (HP:0000741)1.76635697
131Intellectual disability, severe (HP:0010864)1.73710124
132Retinal dysplasia (HP:0007973)1.73137535
133Optic nerve hypoplasia (HP:0000609)1.73126082
134Decreased muscle mass (HP:0003199)1.70500827
135Poor coordination (HP:0002370)1.67946258
136Hypoplasia of the corpus callosum (HP:0002079)1.66693289
137Failure to thrive in infancy (HP:0001531)1.66574726
138Abnormal hair whorl (HP:0010721)1.62141736

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.32669159
2MARK13.99601684
3MAP3K93.86697424
4EPHA43.68085500
5MAP3K43.40528067
6MAP2K73.01803847
7CASK2.96237750
8MINK12.78471736
9DAPK22.65350039
10MAP3K122.54735776
11RIPK42.48300851
12MAP2K42.19954892
13BCR2.10197522
14TRIM281.99019930
15DAPK11.92563534
16KSR21.90803790
17PAK61.87207483
18PNCK1.86820647
19PLK21.85980498
20NTRK21.81436690
21NTRK11.70665775
22KSR11.70040921
23CDK191.66993325
24MAPK131.58818918
25PINK11.57159164
26GRK51.55416822
27CAMKK11.54010287
28TNIK1.47025003
29CDK51.44821324
30SIK21.39737314
31LATS21.38296121
32BMPR1B1.27400385
33INSRR1.24663197
34PRPF4B1.21767805
35MAP3K21.19731709
36PRKCG1.15963356
37DYRK31.15811218
38CAMKK21.15688405
39MAP4K21.07336529
40PHKG21.06329303
41PHKG11.06329303
42ARAF1.06253481
43ADRBK21.06036321
44CAMK2A1.02612904
45CCNB11.01042545
46BMPR20.96960314
47PRKD30.96513077
48FES0.95470104
49MKNK20.94411259
50CSNK1G30.94003110
51RET0.90217850
52AKT30.90043868
53STK380.89080620
54CSNK1G20.88464569
55CDK180.85555311
56CSNK1G10.83698484
57RAF10.83424573
58UHMK10.83386943
59CDK140.83349061
60MAP3K60.82430407
61PTK2B0.82060837
62CDK150.81469127
63CSNK1A1L0.81365813
64MAP3K130.80834720
65CAMK10.79273526
66PKN10.78409401
67STK110.77442071
68CAMK2B0.77382006
69NME10.76090418
70OXSR10.74492890
71EPHA30.73745529
72SCYL20.72237222
73SGK20.71349323
74DYRK1A0.71174251
75CDK11A0.70128624
76SGK4940.69942430
77SGK2230.69942430
78EPHB20.69635112
79TAOK10.66267926
80SGK10.64557699
81GRK10.62840464
82TYRO30.61827433
83PAK30.61521387
84PDK10.58373009
85FRK0.56459139
86MARK20.55547376
87PRKCE0.53489444
88FGR0.52859968
89SGK30.51696865
90MAPK120.50549390
91PRKCZ0.47654222
92PRKG10.47639662
93PDPK10.46682452
94TSSK60.46565877
95PRKCH0.45730739
96CAMK1G0.45265157
97STK390.44754373
98LMTK20.44479539
99MAP3K10.43590541
100SIK30.43440096
101CSNK1E0.43326657
102RPS6KA20.42103435
103PRKACA0.41947385
104RPS6KA40.41758449
105FYN0.41399075
106MAP2K10.40671996
107FER0.40085804
108WNK40.39850256
109ERBB30.38979821
110PRKACB0.38604894
111RPS6KA30.37889702
112MAPKAPK50.37362449
113CSNK1D0.36759074
114MAP3K70.36730471
115CAMK2D0.36258865
116DAPK30.35610084
117MKNK10.35531398
118DYRK1B0.34479886
119WNK30.32268314
120PLK30.32201635
121ALK0.31762615
122MAPK100.31559677
123PDK40.30685091
124PDK30.30685091
125ACVR1B0.30500871
126PRKCB0.30139755
127DYRK20.29883715
128CSNK1A10.29403208
129LIMK10.29300126
130TAF10.27618289
131ADRBK10.27408068
132TNK20.27108409
133MAP3K50.26840563
134TIE10.26749200
135CAMK40.26498427
136CAMK2G0.26384516
137MAPK90.25523826

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.81117754
2Synaptic vesicle cycle_Homo sapiens_hsa047213.34217642
3Long-term potentiation_Homo sapiens_hsa047202.89826976
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.75050929
5Circadian entrainment_Homo sapiens_hsa047132.68054955
6Glutamatergic synapse_Homo sapiens_hsa047242.56313624
7Olfactory transduction_Homo sapiens_hsa047402.53624954
8Amphetamine addiction_Homo sapiens_hsa050312.50113714
9GABAergic synapse_Homo sapiens_hsa047272.48691097
10Morphine addiction_Homo sapiens_hsa050322.42347855
11Dopaminergic synapse_Homo sapiens_hsa047282.24505681
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.20818393
13Salivary secretion_Homo sapiens_hsa049702.19870369
14Insulin secretion_Homo sapiens_hsa049111.90765313
15Renin secretion_Homo sapiens_hsa049241.86727849
16Cholinergic synapse_Homo sapiens_hsa047251.86187429
17Long-term depression_Homo sapiens_hsa047301.83204122
18Gastric acid secretion_Homo sapiens_hsa049711.83139876
19Taste transduction_Homo sapiens_hsa047421.83117168
20Serotonergic synapse_Homo sapiens_hsa047261.79492696
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.76905039
22Collecting duct acid secretion_Homo sapiens_hsa049661.73178256
23Oxytocin signaling pathway_Homo sapiens_hsa049211.69273928
24Calcium signaling pathway_Homo sapiens_hsa040201.58842627
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.57485567
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.52579331
27GnRH signaling pathway_Homo sapiens_hsa049121.49286435
28Cocaine addiction_Homo sapiens_hsa050301.46500089
29Gap junction_Homo sapiens_hsa045401.43747425
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.40670446
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.40635934
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.36023436
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.29345520
34Oxidative phosphorylation_Homo sapiens_hsa001901.26466888
35Glioma_Homo sapiens_hsa052141.24842143
36Parkinsons disease_Homo sapiens_hsa050121.23994283
37Estrogen signaling pathway_Homo sapiens_hsa049151.23834952
38Axon guidance_Homo sapiens_hsa043601.22800035
39cAMP signaling pathway_Homo sapiens_hsa040241.20839950
40Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.20710143
41Protein export_Homo sapiens_hsa030601.16496415
42ErbB signaling pathway_Homo sapiens_hsa040121.16369152
43Steroid biosynthesis_Homo sapiens_hsa001001.16271962
44Phosphatidylinositol signaling system_Homo sapiens_hsa040701.14703207
45Type II diabetes mellitus_Homo sapiens_hsa049301.11884799
46Vibrio cholerae infection_Homo sapiens_hsa051101.08903628
47Melanogenesis_Homo sapiens_hsa049161.06554479
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.06099293
49cGMP-PKG signaling pathway_Homo sapiens_hsa040221.06074431
50Butanoate metabolism_Homo sapiens_hsa006501.04298911
51Oocyte meiosis_Homo sapiens_hsa041140.97451472
52Phototransduction_Homo sapiens_hsa047440.96443713
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.92079352
54Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.89287668
55Dorso-ventral axis formation_Homo sapiens_hsa043200.88691778
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.87376048
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86647513
58Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.85007873
59Cardiac muscle contraction_Homo sapiens_hsa042600.84262337
60Pancreatic secretion_Homo sapiens_hsa049720.79841309
61Choline metabolism in cancer_Homo sapiens_hsa052310.79277324
62VEGF signaling pathway_Homo sapiens_hsa043700.77558434
63Phospholipase D signaling pathway_Homo sapiens_hsa040720.76850919
64Huntingtons disease_Homo sapiens_hsa050160.75533147
65Thyroid hormone synthesis_Homo sapiens_hsa049180.75297304
66Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.74984439
67Ether lipid metabolism_Homo sapiens_hsa005650.73784267
68Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.72904076
69Basal transcription factors_Homo sapiens_hsa030220.72775084
70MAPK signaling pathway_Homo sapiens_hsa040100.72632802
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72242541
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.69710768
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.69576378
74Hippo signaling pathway_Homo sapiens_hsa043900.63957048
75Endometrial cancer_Homo sapiens_hsa052130.63403256
76Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62663564
77Ras signaling pathway_Homo sapiens_hsa040140.60911893
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.60482301
79Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60296506
80Selenocompound metabolism_Homo sapiens_hsa004500.58868018
81Linoleic acid metabolism_Homo sapiens_hsa005910.58396823
82Glucagon signaling pathway_Homo sapiens_hsa049220.58230696
83Dilated cardiomyopathy_Homo sapiens_hsa054140.57010492
84mTOR signaling pathway_Homo sapiens_hsa041500.56598123
85Maturity onset diabetes of the young_Homo sapiens_hsa049500.56048720
86Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.54750767
87Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54035864
88alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53318486
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52791977
90African trypanosomiasis_Homo sapiens_hsa051430.52592173
91Hedgehog signaling pathway_Homo sapiens_hsa043400.52229837
92Rap1 signaling pathway_Homo sapiens_hsa040150.51911881
93Alzheimers disease_Homo sapiens_hsa050100.50863874
94Alcoholism_Homo sapiens_hsa050340.50522428
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50369226
96Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50239102
97Regulation of autophagy_Homo sapiens_hsa041400.50176779
98Wnt signaling pathway_Homo sapiens_hsa043100.49592708
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49191919
100Non-small cell lung cancer_Homo sapiens_hsa052230.48663750
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47543594
102Inositol phosphate metabolism_Homo sapiens_hsa005620.47521123
103Ovarian steroidogenesis_Homo sapiens_hsa049130.46626958
104Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.45255677
105Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45165468
106Renal cell carcinoma_Homo sapiens_hsa052110.44138077
107Insulin signaling pathway_Homo sapiens_hsa049100.43658739
108Colorectal cancer_Homo sapiens_hsa052100.43211860
109Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.42889087
110Circadian rhythm_Homo sapiens_hsa047100.42160271
111Tight junction_Homo sapiens_hsa045300.41560547
112Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.41128111
113Nitrogen metabolism_Homo sapiens_hsa009100.40345401
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39812983
115Endocytosis_Homo sapiens_hsa041440.39469375
116Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39079264
117Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.38112412
118Prion diseases_Homo sapiens_hsa050200.37061980
119Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.34508001
120Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.33551122
121SNARE interactions in vesicular transport_Homo sapiens_hsa041300.30521199
122Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.29841252
123Chemokine signaling pathway_Homo sapiens_hsa040620.29596991
124Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.28795223
125Prolactin signaling pathway_Homo sapiens_hsa049170.28524967
126Type I diabetes mellitus_Homo sapiens_hsa049400.27698263
127Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.27639192
128Bile secretion_Homo sapiens_hsa049760.26700759
129Rheumatoid arthritis_Homo sapiens_hsa053230.26209536
130Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.24201998

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