PGAM1P7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1dosage compensation (GO:0007549)6.03680299
2regulation of centriole replication (GO:0046599)5.42801855
3piRNA metabolic process (GO:0034587)4.70798171
4protein K6-linked ubiquitination (GO:0085020)4.41650028
5terpenoid biosynthetic process (GO:0016114)4.35524328
6regulation of ER to Golgi vesicle-mediated transport (GO:0060628)4.22735435
7regulation of DNA endoreduplication (GO:0032875)4.13140804
8regulation of B cell receptor signaling pathway (GO:0050855)3.92438509
9regulation of histone H3-K9 methylation (GO:0051570)3.84645064
10cellular response to antibiotic (GO:0071236)3.76146690
11maturation of 5.8S rRNA (GO:0000460)3.72345932
12diterpenoid biosynthetic process (GO:0016102)3.64041902
13nuclear pore organization (GO:0006999)3.50404846
14keratinocyte development (GO:0003334)3.47347296
15regulation of chromatin silencing (GO:0031935)3.46415369
16histone H3-K36 demethylation (GO:0070544)3.42694083
17positive regulation of natural killer cell differentiation (GO:0032825)3.34718539
18positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.34646660
19regulation of RNA export from nucleus (GO:0046831)3.31824689
20centriole replication (GO:0007099)3.28353702
21mature B cell differentiation (GO:0002335)3.24493946
22positive regulation of interleukin-17 production (GO:0032740)3.12579722
23B cell receptor signaling pathway (GO:0050853)3.12436166
24mitotic sister chromatid cohesion (GO:0007064)3.05943418
25sister chromatid cohesion (GO:0007062)3.05770263
26cell wall macromolecule catabolic process (GO:0016998)3.04036001
27DNA methylation involved in gamete generation (GO:0043046)3.00434461
28ribosome assembly (GO:0042255)2.98481611
29nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.97807674
30regulation of defense response to virus by host (GO:0050691)2.97370530
31B cell proliferation (GO:0042100)2.97001504
32negative regulation of organelle assembly (GO:1902116)2.93961111
33proteasome assembly (GO:0043248)2.90371231
34cellular response to vitamin D (GO:0071305)2.90072999
35gene silencing by RNA (GO:0031047)2.86877663
36peroxisome fission (GO:0016559)2.86452103
37positive regulation of protein homodimerization activity (GO:0090073)2.83883615
38ear development (GO:0043583)2.83661588
39regulation of p38MAPK cascade (GO:1900744)2.83207726
40cellular response to dsRNA (GO:0071359)2.79076810
41striated muscle atrophy (GO:0014891)2.78176977
42positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.77192120
43response to hydroperoxide (GO:0033194)2.76387352
44postreplication repair (GO:0006301)2.74477233
45histone mRNA catabolic process (GO:0071044)2.73553216
46ventricular system development (GO:0021591)2.73009652
47negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.71564606
48regulation of cellular amino acid metabolic process (GO:0006521)2.69044924
49regulation of germinal center formation (GO:0002634)2.66810389
50nuclear pore complex assembly (GO:0051292)2.65869047
51muscle atrophy (GO:0014889)2.64392002
52regulation of T-helper 1 cell differentiation (GO:0045625)2.63990563
53formation of translation preinitiation complex (GO:0001731)2.63540013
54positive regulation of histone H3-K4 methylation (GO:0051571)2.63003183
55regulation of interferon-beta production (GO:0032648)2.61367970
56pinocytosis (GO:0006907)2.60717291
57positive regulation of granulocyte differentiation (GO:0030854)2.60469775
58rRNA catabolic process (GO:0016075)2.60163801
59regulation of centrosome duplication (GO:0010824)2.59186447
60mitochondrial calcium ion transport (GO:0006851)2.57258124
61DNA geometric change (GO:0032392)2.56927069
62regulation of cholesterol esterification (GO:0010872)2.56798673
63regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.56541658
64synapsis (GO:0007129)2.56353944
65CENP-A containing nucleosome assembly (GO:0034080)2.56108527
66DNA duplex unwinding (GO:0032508)2.55830217
67positive regulation of mitochondrial fission (GO:0090141)2.55390611
68cellular response to exogenous dsRNA (GO:0071360)2.54703232
69regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.53334622
70positive regulation of interferon-beta production (GO:0032728)2.52593795
71DNA unwinding involved in DNA replication (GO:0006268)2.52214820
72ER overload response (GO:0006983)2.49922689
73regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.49275679
74negative regulation of ligase activity (GO:0051352)2.48776529
75negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.48776529
76negative regulation of calcium ion transport into cytosol (GO:0010523)2.48768372
77AMP metabolic process (GO:0046033)2.48276374
78DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.48131136
79negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.47483702
80RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.47330310
81signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.46919914
82intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.46919914
83mammary gland epithelial cell proliferation (GO:0033598)2.46313153
84G2 DNA damage checkpoint (GO:0031572)2.45357114
85natural killer cell differentiation (GO:0001779)2.44848036
86anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.44020277
87cellular response to interleukin-4 (GO:0071353)2.43412876
88signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.43265690
89signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.43265690
90signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.43265690
91negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.42079869
92lymphocyte proliferation (GO:0046651)2.41817867
93mitotic G2 DNA damage checkpoint (GO:0007095)2.40204503
94mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.39947397
95positive regulation of tyrosine phosphorylation of Stat3 protein (GO:0042517)2.39784395
96negative regulation of striated muscle cell apoptotic process (GO:0010664)2.39084917
97skeletal muscle adaptation (GO:0043501)2.37895195
98regulation of centrosome cycle (GO:0046605)2.37812115
99cell wall macromolecule metabolic process (GO:0044036)2.37763532
100regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.37193534

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.61885767
2RBPJ_22232070_ChIP-Seq_NCS_Mouse3.86279868
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.59478913
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.11547369
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.10362071
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.88714019
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.75638396
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.69053105
9VDR_23849224_ChIP-Seq_CD4+_Human2.65671670
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.44166098
11ESR1_15608294_ChIP-ChIP_MCF-7_Human2.39538500
12STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.35607353
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.27149399
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.25784992
15PADI4_21655091_ChIP-ChIP_MCF-7_Human2.20353332
16FOXP3_21729870_ChIP-Seq_TREG_Human2.10859932
17FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.10368969
18E2F1_21310950_ChIP-Seq_MCF-7_Human2.05987620
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.04695441
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.97770288
21SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.97218034
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.94641413
23SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.89807603
24POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.87247980
25DCP1A_22483619_ChIP-Seq_HELA_Human1.86834193
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.85566844
27FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.79805671
28ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.78815490
29PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76831277
30KDM5A_27292631_Chip-Seq_BREAST_Human1.71647612
31PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.71025448
32TFEB_21752829_ChIP-Seq_HELA_Human1.70455904
33IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.69947016
34MYB_21317192_ChIP-Seq_ERMYB_Mouse1.68444606
35MYB_26560356_Chip-Seq_TH2_Human1.67704896
36CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.64801939
37ETS1_20019798_ChIP-Seq_JURKAT_Human1.64618215
38SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.64230805
39SALL1_21062744_ChIP-ChIP_HESCs_Human1.61544218
40MYC_22102868_ChIP-Seq_BL_Human1.61202051
41SPI1_23547873_ChIP-Seq_NB4_Human1.59945166
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.59718525
43MYB_26560356_Chip-Seq_TH1_Human1.56954056
44MYC_19030024_ChIP-ChIP_MESCs_Mouse1.55635966
45KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.54776183
46TP63_19390658_ChIP-ChIP_HaCaT_Human1.52989304
47GABP_19822575_ChIP-Seq_HepG2_Human1.49785912
48ELF5_23300383_ChIP-Seq_T47D_Human1.46646401
49CREB1_15753290_ChIP-ChIP_HEK293T_Human1.41226870
50AR_21909140_ChIP-Seq_LNCAP_Human1.38739293
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.37106369
52NELFA_20434984_ChIP-Seq_ESCs_Mouse1.36424190
53IRF8_21731497_ChIP-ChIP_J774_Mouse1.34059199
54ERG_20887958_ChIP-Seq_HPC-7_Mouse1.32776744
55SRF_21415370_ChIP-Seq_HL-1_Mouse1.32563666
56CIITA_25753668_ChIP-Seq_RAJI_Human1.32189315
57GATA1_22025678_ChIP-Seq_K562_Human1.31547909
58ELK1_19687146_ChIP-ChIP_HELA_Human1.29372362
59CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.29155760
60MYC_18358816_ChIP-ChIP_MESCs_Mouse1.28900567
61NOTCH1_21737748_ChIP-Seq_TLL_Human1.26201017
62PKCTHETA_26484144_Chip-Seq_BREAST_Human1.24514888
63HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.24021126
64PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.22943788
65MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.21444624
66ESR1_20079471_ChIP-ChIP_T-47D_Human1.21284830
67SMAD_19615063_ChIP-ChIP_OVARY_Human1.20396060
68EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.20025576
69E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.18574826
70SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.17571950
71YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16890319
72FLI1_27457419_Chip-Seq_LIVER_Mouse1.16437545
73TTF2_22483619_ChIP-Seq_HELA_Human1.15899865
74E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.11328675
75MYCN_18555785_ChIP-Seq_MESCs_Mouse1.11132548
76MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.10960538
77MYC_19079543_ChIP-ChIP_MESCs_Mouse1.08176197
78VDR_24787735_ChIP-Seq_THP-1_Human1.07187375
79GATA3_26560356_Chip-Seq_TH2_Human1.07040294
80HIF1A_21447827_ChIP-Seq_MCF-7_Human1.07027838
81FOXM1_23109430_ChIP-Seq_U2OS_Human1.06115150
82ZNF274_21170338_ChIP-Seq_K562_Hela1.05586858
83PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.04696359
84EGR1_23403033_ChIP-Seq_LIVER_Mouse1.04675674
85E2F1_18555785_ChIP-Seq_MESCs_Mouse1.03752769
86GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.03173529
87GATA3_27048872_Chip-Seq_THYMUS_Human1.02627342
88ERG_20517297_ChIP-Seq_VCAP_Human1.00699262
89ZFX_18555785_ChIP-Seq_MESCs_Mouse1.00147480
90IRF8_27001747_Chip-Seq_BMDM_Mouse0.99319378
91HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.98752787
92NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.98716800
93XRN2_22483619_ChIP-Seq_HELA_Human0.94546828
94TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94521718
95TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.92129359
96BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.91554281
97GATA3_24758297_ChIP-Seq_MCF-7_Human0.89862614
98STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.86974817
99BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.86715752
100IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.85797580

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.41986952
2MP0010094_abnormal_chromosome_stability3.68709626
3MP0005451_abnormal_body_composition3.20593953
4MP0003693_abnormal_embryo_hatching3.18561792
5MP0001835_abnormal_antigen_presentation3.16789188
6MP0000427_abnormal_hair_cycle2.77291757
7MP0002396_abnormal_hematopoietic_system2.74687050
8MP0008877_abnormal_DNA_methylation2.61749626
9MP0000372_irregular_coat_pigmentation2.56043963
10MP0002139_abnormal_hepatobiliary_system2.51879227
11MP0005408_hypopigmentation2.37321141
12MP0003950_abnormal_plasma_membrane2.27431045
13MP0002138_abnormal_hepatobiliary_system2.27430299
14MP0009697_abnormal_copulation2.23326521
15MP0003828_pulmonary_edema2.14351607
16MP0010307_abnormal_tumor_latency2.12699261
17MP0010234_abnormal_vibrissa_follicle2.08515305
18MP0003077_abnormal_cell_cycle2.08465944
19MP0003221_abnormal_cardiomyocyte_apopto2.02178848
20MP0005084_abnormal_gallbladder_morpholo2.01978092
21MP0001800_abnormal_humoral_immune1.95349851
22MP0003172_abnormal_lysosome_physiology1.88062263
23MP0002166_altered_tumor_susceptibility1.86788302
24MP0000749_muscle_degeneration1.84068445
25MP0003786_premature_aging1.80572504
26MP0002006_tumorigenesis1.74534245
27MP0004957_abnormal_blastocyst_morpholog1.73827258
28MP0003111_abnormal_nucleus_morphology1.63231687
29MP0004808_abnormal_hematopoietic_stem1.57759159
30MP0008058_abnormal_DNA_repair1.56428775
31MP0008007_abnormal_cellular_replicative1.53823098
32MP0004264_abnormal_extraembryonic_tissu1.52713902
33MP0000685_abnormal_immune_system1.49429908
34MP0002796_impaired_skin_barrier1.46911091
35MP0001853_heart_inflammation1.42693352
36MP0002452_abnormal_antigen_presenting1.42074243
37MP0005075_abnormal_melanosome_morpholog1.40878086
38MP0000467_abnormal_esophagus_morphology1.40057601
39MP0002837_dystrophic_cardiac_calcinosis1.30743422
40MP0002098_abnormal_vibrissa_morphology1.29751551
41MP0000350_abnormal_cell_proliferation1.29011710
42MP0003787_abnormal_imprinting1.26648395
43MP0002398_abnormal_bone_marrow1.23140193
44MP0002723_abnormal_immune_serum1.23042148
45MP0001216_abnormal_epidermal_layer1.15321824
46MP0010678_abnormal_skin_adnexa1.14012429
47MP0001697_abnormal_embryo_size1.13469720
48MP0001819_abnormal_immune_cell1.12443710
49MP0005000_abnormal_immune_tolerance1.12270806
50MP0002420_abnormal_adaptive_immunity1.10793019
51MP0003186_abnormal_redox_activity1.09986292
52MP0002127_abnormal_cardiovascular_syste1.07123398
53MP0000627_abnormal_mammary_gland1.06842172
54MP0002019_abnormal_tumor_incidence1.05969637
55MP0006035_abnormal_mitochondrial_morpho1.04971864
56MP0001881_abnormal_mammary_gland1.04881797
57MP0003718_maternal_effect1.03785337
58MP0000689_abnormal_spleen_morphology1.03766510
59MP0006054_spinal_hemorrhage1.03649531
60MP0000716_abnormal_immune_system1.00862018
61MP0000313_abnormal_cell_death1.00700407
62MP0000377_abnormal_hair_follicle0.99579257
63MP0006036_abnormal_mitochondrial_physio0.98513460
64MP0003091_abnormal_cell_migration0.97727014
65MP0001790_abnormal_immune_system0.97445629
66MP0005387_immune_system_phenotype0.97445629
67MP0001764_abnormal_homeostasis0.96463912
68MP0010352_gastrointestinal_tract_polyps0.95914515
69MP0002210_abnormal_sex_determination0.95763001
70MP0003763_abnormal_thymus_physiology0.94371824
71MP0002148_abnormal_hypersensitivity_rea0.92468948
72MP0003984_embryonic_growth_retardation0.90439244
73MP0009333_abnormal_splenocyte_physiolog0.90174389
74MP0002429_abnormal_blood_cell0.88517769
75MP0002877_abnormal_melanocyte_morpholog0.88370751
76MP0000383_abnormal_hair_follicle0.88105719
77MP0002722_abnormal_immune_system0.86799123
78MP0001191_abnormal_skin_condition0.85464744
79MP0000358_abnormal_cell_content/0.85015840
80MP0008932_abnormal_embryonic_tissue0.84967056
81MP0002088_abnormal_embryonic_growth/wei0.84896200
82MP0002269_muscular_atrophy0.83859729
83MP0000470_abnormal_stomach_morphology0.83126798
84MP0001243_abnormal_dermal_layer0.82953943
85MP0005621_abnormal_cell_physiology0.82878719
86MP0001661_extended_life_span0.82381928
87MP0002928_abnormal_bile_duct0.81509476
88MP0003252_abnormal_bile_duct0.80959232
89MP0002086_abnormal_extraembryonic_tissu0.77234451
90MP0005380_embryogenesis_phenotype0.77066781
91MP0001672_abnormal_embryogenesis/_devel0.77066781
92MP0001730_embryonic_growth_arrest0.76381469
93MP0005501_abnormal_skin_physiology0.73263238
94MP0008961_abnormal_basal_metabolism0.72917037
95MP0001873_stomach_inflammation0.72784389
96MP0005058_abnormal_lysosome_morphology0.72243569
97MP0003936_abnormal_reproductive_system0.71893349
98MP0001666_abnormal_nutrient_absorption0.71431520
99MP0001929_abnormal_gametogenesis0.71233479
100MP0003699_abnormal_female_reproductive0.71125231

Predicted human phenotypes

RankGene SetZ-score
1Febrile seizures (HP:0002373)5.46045296
2Tubulointerstitial nephritis (HP:0001970)4.68847625
3Abnormality of dental color (HP:0011073)4.39088793
4Axonal loss (HP:0003447)4.24463222
5Recurrent bronchitis (HP:0002837)4.11698549
6Diaphragmatic weakness (HP:0009113)4.01111400
7Cone-rod dystrophy (HP:0000548)3.97426630
8Abnormality of the frontal sinuses (HP:0002687)3.97160115
9Alopecia of scalp (HP:0002293)3.69136499
10B lymphocytopenia (HP:0010976)3.55627367
11Amelogenesis imperfecta (HP:0000705)3.50187478
12Sparse lateral eyebrow (HP:0005338)3.32440949
13Abnormality of B cell number (HP:0010975)3.07900813
14Chronic sinusitis (HP:0011109)3.06862173
15Microretrognathia (HP:0000308)2.97902043
16Renal cortical cysts (HP:0000803)2.94138995
17Agammaglobulinemia (HP:0004432)2.85466111
18Spinal cord lesions (HP:0100561)2.68043312
19Syringomyelia (HP:0003396)2.68043312
20Ureteral obstruction (HP:0006000)2.66213482
21Neonatal respiratory distress (HP:0002643)2.65873693
22Ragged-red muscle fibers (HP:0003200)2.58471060
23Colitis (HP:0002583)2.57805707
24Hypoplasia of the uterus (HP:0000013)2.54509874
25Abnormal umbilical cord blood vessels (HP:0011403)2.53577211
26Single umbilical artery (HP:0001195)2.53577211
27Abnormality of the fetal cardiovascular system (HP:0010948)2.53577211
28Unilateral renal agenesis (HP:0000122)2.53306628
29Aplasia/Hypoplasia of the sacrum (HP:0008517)2.52877766
30Aqueductal stenosis (HP:0002410)2.50077647
31Hypoplasia of the thymus (HP:0000778)2.49913910
32Gout (HP:0001997)2.49625856
33Bronchitis (HP:0012387)2.44804149
34Anal stenosis (HP:0002025)2.42538475
35Recurrent gram-negative bacterial infections (HP:0005420)2.41623622
36Glucose intolerance (HP:0000833)2.40294255
37Hypothermia (HP:0002045)2.38414057
38Chromosomal breakage induced by crosslinking agents (HP:0003221)2.33192460
39Panhypogammaglobulinemia (HP:0003139)2.31341833
40Prominent nose (HP:0000448)2.27293438
41Decreased central vision (HP:0007663)2.25863900
42Reduced antithrombin III activity (HP:0001976)2.25411595
43Fragile nails (HP:0001808)2.25273294
44Recurrent viral infections (HP:0004429)2.23980350
45Chronic diarrhea (HP:0002028)2.22437234
46Rhabdomyosarcoma (HP:0002859)2.22401486
47Short chin (HP:0000331)2.20769996
48Chromsome breakage (HP:0040012)2.19616389
49Abnormality of chromosome stability (HP:0003220)2.18534940
50Aplasia/Hypoplasia of the thymus (HP:0010515)2.16752032
51Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.16200783
52Ureteral stenosis (HP:0000071)2.15066863
53Woolly hair (HP:0002224)2.14577243
54Personality changes (HP:0000751)2.13599247
55Macroorchidism (HP:0000053)2.11833267
56Clubbing of toes (HP:0100760)2.09166117
57Increased neuronal autofluorescent lipopigment (HP:0002074)2.08725710
58Glioma (HP:0009733)2.05863894
59Acute myeloid leukemia (HP:0004808)2.03352457
60Abnormality of the umbilical cord (HP:0010881)1.99624210
61Recurrent abscess formation (HP:0002722)1.99480632
62Abnormal pancreas size (HP:0012094)1.99266714
63Seborrheic dermatitis (HP:0001051)1.99228549
64Gastrointestinal infarctions (HP:0005244)1.97812948
65Mediastinal lymphadenopathy (HP:0100721)1.95442687
66Lip pit (HP:0100267)1.95299552
67Tubular atrophy (HP:0000092)1.95086979
68Shawl scrotum (HP:0000049)1.93369396
69Myelodysplasia (HP:0002863)1.93174151
70Absent frontal sinuses (HP:0002688)1.92140827
71Acute lymphatic leukemia (HP:0006721)1.91570732
72Erythema (HP:0010783)1.90787649
73Metaphyseal dysplasia (HP:0100255)1.89802398
74Facial diplegia (HP:0001349)1.89689557
75Short clavicles (HP:0000894)1.89592150
76Abnormality of the astrocytes (HP:0100707)1.88512918
77Astrocytoma (HP:0009592)1.88512918
78Abnormality of transition element cation homeostasis (HP:0011030)1.88347286
79Selective tooth agenesis (HP:0001592)1.83559535
80Aplasia/Hypoplasia of the uvula (HP:0010293)1.83266263
81Autoimmune hemolytic anemia (HP:0001890)1.82390226
82Short nail (HP:0001799)1.82150606
83Deep philtrum (HP:0002002)1.80847746
84Microvesicular hepatic steatosis (HP:0001414)1.78816156
85Hypoparathyroidism (HP:0000829)1.77807362
86Osteomalacia (HP:0002749)1.75545754
87Freckling (HP:0001480)1.74639812
88Hypoproteinemia (HP:0003075)1.74515574
89Abnormality of the preputium (HP:0100587)1.73480554
90Deep palmar crease (HP:0006191)1.73310095
91Abnormal rod and cone electroretinograms (HP:0008323)1.71954606
92Follicular hyperkeratosis (HP:0007502)1.70957976
93Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.69959232
94Rectovaginal fistula (HP:0000143)1.69861776
95Rectal fistula (HP:0100590)1.69861776
96Short middle phalanx of the 5th finger (HP:0004220)1.69504929
97Hepatic necrosis (HP:0002605)1.69396901
98Tubulointerstitial abnormality (HP:0001969)1.69291551
99Atelectasis (HP:0100750)1.68533068
100Gastrointestinal stroma tumor (HP:0100723)1.68254379

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BMPR26.65526525
2CDK194.28232104
3RIPK43.94697719
4EIF2AK33.31307671
5MST42.67405700
6PLK42.61043308
7CASK2.57774843
8AKT32.52822237
9BRD42.48533598
10SCYL22.43242432
11PNCK2.42428094
12CCNB12.32448387
13STK162.00435310
14MAP3K121.99564174
15TAF11.83416915
16STK391.77116622
17OXSR11.66455350
18TESK21.55484888
19NUAK11.52943821
20CDC71.49550552
21EIF2AK11.41249464
22CDK41.37346045
23IKBKB1.36496866
24NME21.35982679
25TRIM281.32562301
26MAP3K141.31054080
27KIT1.21285919
28TSSK61.19795120
29MST1R1.19011173
30MAP4K11.18293920
31ILK1.18235761
32CAMK1G1.17026830
33TRPM71.16788694
34RPS6KB21.15416566
35MATK1.13372755
36CSF1R1.12712349
37TEC1.11746924
38VRK21.10335785
39ATR1.03496523
40TAOK31.03093048
41CDK71.02306164
42CDK30.95938451
43LRRK20.93837218
44TBK10.90978758
45DAPK10.90659151
46MUSK0.89733725
47EIF2AK20.81382107
48IRAK10.71332197
49BTK0.70544261
50TNIK0.67730653
51BUB10.67337242
52CDK120.66832535
53ERBB30.65993647
54CHEK10.63971891
55MAPKAPK30.59664948
56PAK40.59321353
57SYK0.59160066
58MAP2K60.58352430
59VRK10.58339174
60SMG10.57649723
61STK380.57583253
62CHEK20.56467080
63STK40.55575166
64MARK30.54743534
65FRK0.53716482
66OBSCN0.53514041
67IKBKE0.52029553
68PLK10.51824794
69EPHA20.51178692
70WEE10.47934459
71WNK40.47682921
72RPS6KA40.47551267
73PRKD20.46905387
74PBK0.46604235
75CDK60.46241413
76ABL10.45848577
77HCK0.45620248
78CDK80.44947343
79MKNK20.42075292
80ATM0.41942066
81TXK0.40019320
82CDK90.36483596
83ITK0.36194191
84BRSK20.35178806
85NEK10.34876284
86AURKB0.34788496
87SIK30.34294817
88CSNK2A20.31430789
89IRAK40.29175084
90MKNK10.28056419
91NME10.27408235
92MAPK70.25548605
93MTOR0.25307333
94PIK3CG0.25117214
95TTK0.24986622
96CDK10.24581738
97CSNK2A10.24301748
98PIM20.23981176
99JAK30.23408205
100PLK30.22660830

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.83933356
2Intestinal immune network for IgA production_Homo sapiens_hsa046723.48253832
3Asthma_Homo sapiens_hsa053103.39903819
4Allograft rejection_Homo sapiens_hsa053302.59566885
5Autoimmune thyroid disease_Homo sapiens_hsa053202.45049579
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.40955760
7DNA replication_Homo sapiens_hsa030302.33793634
8Homologous recombination_Homo sapiens_hsa034402.28653064
9Graft-versus-host disease_Homo sapiens_hsa053322.25885809
10RNA degradation_Homo sapiens_hsa030182.19459479
11Protein export_Homo sapiens_hsa030602.05910620
12Non-homologous end-joining_Homo sapiens_hsa034502.04002090
13Type I diabetes mellitus_Homo sapiens_hsa049402.02481199
14Antigen processing and presentation_Homo sapiens_hsa046121.99631422
15RNA transport_Homo sapiens_hsa030131.95266263
16B cell receptor signaling pathway_Homo sapiens_hsa046621.82254109
17Fanconi anemia pathway_Homo sapiens_hsa034601.81829770
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.80235607
19Base excision repair_Homo sapiens_hsa034101.76834385
20Rheumatoid arthritis_Homo sapiens_hsa053231.70449928
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.67946745
22Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.60693463
23Spliceosome_Homo sapiens_hsa030401.59588554
24RNA polymerase_Homo sapiens_hsa030201.50515123
25Cell cycle_Homo sapiens_hsa041101.44464798
26Collecting duct acid secretion_Homo sapiens_hsa049661.43212364
27Herpes simplex infection_Homo sapiens_hsa051681.38998543
28Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.37481835
29Viral myocarditis_Homo sapiens_hsa054161.36550069
30Primary immunodeficiency_Homo sapiens_hsa053401.19951016
31mRNA surveillance pathway_Homo sapiens_hsa030151.19710168
32Nucleotide excision repair_Homo sapiens_hsa034201.19246351
33Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.18339223
34Leishmaniasis_Homo sapiens_hsa051401.16890067
35Mismatch repair_Homo sapiens_hsa034301.14057490
36Influenza A_Homo sapiens_hsa051641.12593998
37Other glycan degradation_Homo sapiens_hsa005111.12445235
38Hepatitis B_Homo sapiens_hsa051611.09274783
39Vibrio cholerae infection_Homo sapiens_hsa051101.09263215
40Selenocompound metabolism_Homo sapiens_hsa004501.07020797
41Propanoate metabolism_Homo sapiens_hsa006401.06885962
42One carbon pool by folate_Homo sapiens_hsa006701.05654281
43Glycosaminoglycan degradation_Homo sapiens_hsa005311.04714624
44Toxoplasmosis_Homo sapiens_hsa051451.02823920
45Basal transcription factors_Homo sapiens_hsa030221.01211666
46Epstein-Barr virus infection_Homo sapiens_hsa051690.99846511
47Small cell lung cancer_Homo sapiens_hsa052220.99796859
48Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.98006671
49Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.95854806
50Pyrimidine metabolism_Homo sapiens_hsa002400.93880778
51Sulfur metabolism_Homo sapiens_hsa009200.93355935
52p53 signaling pathway_Homo sapiens_hsa041150.92952277
53Systemic lupus erythematosus_Homo sapiens_hsa053220.90907558
54RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.89055826
55NF-kappa B signaling pathway_Homo sapiens_hsa040640.88399758
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87688198
57Lysine degradation_Homo sapiens_hsa003100.86062052
58Viral carcinogenesis_Homo sapiens_hsa052030.85810163
59Measles_Homo sapiens_hsa051620.84405167
60Tuberculosis_Homo sapiens_hsa051520.80171429
61Jak-STAT signaling pathway_Homo sapiens_hsa046300.78762607
62Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.76473629
63Purine metabolism_Homo sapiens_hsa002300.75916561
64HTLV-I infection_Homo sapiens_hsa051660.74381632
65Legionellosis_Homo sapiens_hsa051340.73394688
66Caffeine metabolism_Homo sapiens_hsa002320.72736509
67Acute myeloid leukemia_Homo sapiens_hsa052210.69083522
68TNF signaling pathway_Homo sapiens_hsa046680.63529584
69Shigellosis_Homo sapiens_hsa051310.62457434
70T cell receptor signaling pathway_Homo sapiens_hsa046600.58937317
71Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58754283
72Prostate cancer_Homo sapiens_hsa052150.57060398
73Transcriptional misregulation in cancer_Homo sapiens_hsa052020.56038329
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.55451044
75Toll-like receptor signaling pathway_Homo sapiens_hsa046200.55001144
76Linoleic acid metabolism_Homo sapiens_hsa005910.54813124
77Apoptosis_Homo sapiens_hsa042100.53367070
78Thyroid hormone synthesis_Homo sapiens_hsa049180.52692672
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50558634
80Oocyte meiosis_Homo sapiens_hsa041140.48988754
81Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.48110533
82Dorso-ventral axis formation_Homo sapiens_hsa043200.47860058
83Non-small cell lung cancer_Homo sapiens_hsa052230.46274120
84alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.46161983
85Pancreatic cancer_Homo sapiens_hsa052120.44517600
86Chronic myeloid leukemia_Homo sapiens_hsa052200.43535854
87Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.38911143
88Cysteine and methionine metabolism_Homo sapiens_hsa002700.38635998
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.37486345
90NOD-like receptor signaling pathway_Homo sapiens_hsa046210.36458865
91mTOR signaling pathway_Homo sapiens_hsa041500.35215425
92Arachidonic acid metabolism_Homo sapiens_hsa005900.33470683
93Inositol phosphate metabolism_Homo sapiens_hsa005620.32863097
94Fructose and mannose metabolism_Homo sapiens_hsa000510.28788692
95Platelet activation_Homo sapiens_hsa046110.25017864
96Ether lipid metabolism_Homo sapiens_hsa005650.23754191
97Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.23474262
98beta-Alanine metabolism_Homo sapiens_hsa004100.23362689
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.21948361
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.21184246

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