PGAM1P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)5.95490004
2maturation of 5.8S rRNA (GO:0000460)5.57560825
3signal peptide processing (GO:0006465)5.54023385
4negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.84748452
5retinal cone cell development (GO:0046549)4.84086639
6cullin deneddylation (GO:0010388)4.70444584
7regulation of cellular amino acid metabolic process (GO:0006521)4.66467579
8DNA strand renaturation (GO:0000733)4.55649316
9DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.52576509
10positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.50585017
11negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.49221333
12negative regulation of ligase activity (GO:0051352)4.49221333
13chaperone-mediated protein transport (GO:0072321)4.47863123
14intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)4.43004399
15signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)4.43004399
16positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)4.40025285
17regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)4.40025285
18regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.38802445
19signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)4.38446162
20signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)4.38446162
21signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)4.38446162
22mitochondrial RNA metabolic process (GO:0000959)4.31001431
23cellular response to leptin stimulus (GO:0044320)4.30073967
24ubiquinone biosynthetic process (GO:0006744)4.29176377
25protein deneddylation (GO:0000338)4.20540812
26signal transduction involved in DNA damage checkpoint (GO:0072422)4.18408087
27signal transduction involved in DNA integrity checkpoint (GO:0072401)4.18408087
28fatty acid elongation (GO:0030497)4.15538930
29signal transduction involved in cell cycle checkpoint (GO:0072395)4.11616853
30regulation of chronic inflammatory response (GO:0002676)4.10582723
31ribosome assembly (GO:0042255)4.09348635
32anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.99319950
33ubiquinone metabolic process (GO:0006743)3.97177461
34positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.81503632
35positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.77537501
36DNA deamination (GO:0045006)3.72500765
37response to leptin (GO:0044321)3.71182418
38GTP biosynthetic process (GO:0006183)3.68211836
39energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.66455793
40ATP hydrolysis coupled proton transport (GO:0015991)3.66455793
41mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.61033716
42regulation of MHC class II biosynthetic process (GO:0045346)3.56561975
43protein targeting to mitochondrion (GO:0006626)3.56519565
44regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.53888623
45rRNA modification (GO:0000154)3.53794280
46positive regulation of ligase activity (GO:0051351)3.52562129
47water-soluble vitamin biosynthetic process (GO:0042364)3.48097997
48antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.47627183
49mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.46457202
50transcription elongation from RNA polymerase III promoter (GO:0006385)3.46417157
51termination of RNA polymerase III transcription (GO:0006386)3.46417157
52regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.45114297
53DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.42248644
54quinone biosynthetic process (GO:1901663)3.38655207
55regulation of cellular amine metabolic process (GO:0033238)3.37133165
56UTP biosynthetic process (GO:0006228)3.33688760
57DNA damage response, detection of DNA damage (GO:0042769)3.32313366
58regulation of ubiquitin-protein transferase activity (GO:0051438)3.31967736
59glial cell proliferation (GO:0014009)3.31842549
60spliceosomal snRNP assembly (GO:0000387)3.28477851
61lysine metabolic process (GO:0006553)3.27953956
62lysine catabolic process (GO:0006554)3.27953956
63respiratory electron transport chain (GO:0022904)3.26263693
647-methylguanosine mRNA capping (GO:0006370)3.26182400
65positive regulation of cell cycle arrest (GO:0071158)3.25769269
66response to misfolded protein (GO:0051788)3.25084537
67establishment of protein localization to mitochondrion (GO:0072655)3.24498103
68regulation of isotype switching to IgG isotypes (GO:0048302)3.22739775
69protein localization to mitochondrion (GO:0070585)3.21705533
70electron transport chain (GO:0022900)3.18111320
71rRNA methylation (GO:0031167)3.17484769
727-methylguanosine RNA capping (GO:0009452)3.17168523
73RNA capping (GO:0036260)3.17168523
74replication fork processing (GO:0031297)3.16342675
75antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.15484115
76regulation of cardiac muscle cell contraction (GO:0086004)3.12887998
77regulation of ligase activity (GO:0051340)3.12856428
78amino acid activation (GO:0043038)3.10028304
79tRNA aminoacylation (GO:0043039)3.10028304
80positive regulation of chemokine biosynthetic process (GO:0045080)3.07546468
81pseudouridine synthesis (GO:0001522)3.06649734
82ATP synthesis coupled proton transport (GO:0015986)3.05273261
83energy coupled proton transport, down electrochemical gradient (GO:0015985)3.05273261
84tetrahydrofolate metabolic process (GO:0046653)3.02795245
85signal transduction in response to DNA damage (GO:0042770)2.99146544
86negative regulation of protein ubiquitination (GO:0031397)2.97713492
87mitochondrial respiratory chain complex assembly (GO:0033108)2.94680657
88modulation of growth of symbiont involved in interaction with host (GO:0044144)2.94096128
89regulation of growth of symbiont in host (GO:0044126)2.94096128
90negative regulation of growth of symbiont in host (GO:0044130)2.94096128
91negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.94096128
92protein complex biogenesis (GO:0070271)2.93477915
93regulation of relaxation of muscle (GO:1901077)2.93461993
94coenzyme catabolic process (GO:0009109)2.93165876
95UTP metabolic process (GO:0046051)2.93124541
96preassembly of GPI anchor in ER membrane (GO:0016254)2.92329788
97NADH dehydrogenase complex assembly (GO:0010257)2.91439137
98mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.91439137
99mitochondrial respiratory chain complex I assembly (GO:0032981)2.91439137
100tRNA aminoacylation for protein translation (GO:0006418)2.89872491

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NOTCH1_17114293_ChIP-ChIP_T-ALL_Human5.65760422
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.40053788
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.86206593
4EST1_17652178_ChIP-ChIP_JURKAT_Human4.69152617
5CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.24270625
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.76797213
7CREB1_15753290_ChIP-ChIP_HEK293T_Human3.53584705
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.43412264
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.34666442
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.16121418
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.00467402
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.70869691
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.56617219
14VDR_23849224_ChIP-Seq_CD4+_Human2.52944741
15DCP1A_22483619_ChIP-Seq_HELA_Human2.47887285
16DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.47490178
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.43326698
18YY1_21170310_ChIP-Seq_MESCs_Mouse2.42910585
19PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.40810382
20SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.40741797
21SRF_21415370_ChIP-Seq_HL-1_Mouse2.36781621
22FOXP3_21729870_ChIP-Seq_TREG_Human2.24465021
23EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.17326346
24THAP11_20581084_ChIP-Seq_MESCs_Mouse2.06795586
25PADI4_21655091_ChIP-ChIP_MCF-7_Human2.05091160
26HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.02918080
27MYC_18358816_ChIP-ChIP_MESCs_Mouse2.01570056
28ELK1_19687146_ChIP-ChIP_HELA_Human1.93396391
29MYC_19030024_ChIP-ChIP_MESCs_Mouse1.92791105
30ELF1_17652178_ChIP-ChIP_JURKAT_Human1.90899227
31YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.89781015
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.81010677
33GABP_19822575_ChIP-Seq_HepG2_Human1.75571437
34E2F4_17652178_ChIP-ChIP_JURKAT_Human1.68622256
35XRN2_22483619_ChIP-Seq_HELA_Human1.67168775
36VDR_22108803_ChIP-Seq_LS180_Human1.63542744
37TTF2_22483619_ChIP-Seq_HELA_Human1.62830300
38CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.61633391
39E2F1_18555785_ChIP-Seq_MESCs_Mouse1.60966195
40HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.60445004
41MYC_19079543_ChIP-ChIP_MESCs_Mouse1.58703400
42ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.58700836
43ELK1_22589737_ChIP-Seq_MCF10A_Human1.54801000
44ESR1_15608294_ChIP-ChIP_MCF-7_Human1.54480627
45ZNF274_21170338_ChIP-Seq_K562_Hela1.53199960
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.47493547
47PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47220621
48CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.46557543
49FUS_26573619_Chip-Seq_HEK293_Human1.41395449
50FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.35310525
51NOTCH1_21737748_ChIP-Seq_TLL_Human1.23627666
52CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.22707531
53MYC_18940864_ChIP-ChIP_HL60_Human1.22570025
54CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.21045391
55NANOG_18555785_ChIP-Seq_MESCs_Mouse1.19725853
56PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.19380894
57ERG_20517297_ChIP-Seq_VCAP_Human1.13163466
58IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.10707950
59IRF1_19129219_ChIP-ChIP_H3396_Human1.10440795
60PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.10402187
61KDM5A_27292631_Chip-Seq_BREAST_Human1.08862127
62ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.06945555
63POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.06235365
64GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04766884
65TFEB_21752829_ChIP-Seq_HELA_Human1.04687075
66MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.04260499
67EWS_26573619_Chip-Seq_HEK293_Human1.03315574
68TAF15_26573619_Chip-Seq_HEK293_Human1.02812281
69FLI1_27457419_Chip-Seq_LIVER_Mouse1.01939849
70HIF1A_21447827_ChIP-Seq_MCF-7_Human1.01906600
71FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.01229392
72CIITA_25753668_ChIP-Seq_RAJI_Human0.98120645
73NELFA_20434984_ChIP-Seq_ESCs_Mouse0.97997579
74CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.97264108
75CTBP2_25329375_ChIP-Seq_LNCAP_Human0.95970631
76FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.95573153
77AR_20517297_ChIP-Seq_VCAP_Human0.95402009
78TP53_22573176_ChIP-Seq_HFKS_Human0.93124226
79NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.90763911
80SOX2_18555785_ChIP-Seq_MESCs_Mouse0.90548365
81ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.88217313
82PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.85622233
83SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.85142138
84GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.81993265
85SALL4_22934838_ChIP-ChIP_CD34+_Human0.80650822
86CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.79765224
87BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.75912421
88FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75867266
89PCGF2_27294783_Chip-Seq_ESCs_Mouse0.75425686
90MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.75239969
91MYCN_18555785_ChIP-Seq_MESCs_Mouse0.73211063
92TCF4_22108803_ChIP-Seq_LS180_Human0.72165128
93ELF5_23300383_ChIP-Seq_T47D_Human0.71947572
94KLF5_20875108_ChIP-Seq_MESCs_Mouse0.71781372
95PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.71607053
96ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.71253924
97POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.71080055
98HOXB7_26014856_ChIP-Seq_BT474_Human0.68965740
99KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.68769122
100TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.67487355

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color6.31824117
2MP0001873_stomach_inflammation4.12109874
3MP0001661_extended_life_span3.85444218
4MP0008058_abnormal_DNA_repair3.35201251
5MP0000579_abnormal_nail_morphology3.06845943
6MP0003950_abnormal_plasma_membrane2.86890843
7MP0002638_abnormal_pupillary_reflex2.65304085
8MP0002736_abnormal_nociception_after2.54003982
9MP0005423_abnormal_somatic_nervous2.30137469
10MP0003186_abnormal_redox_activity2.22270823
11MP0005551_abnormal_eye_electrophysiolog2.21858760
12MP0001853_heart_inflammation2.19531564
13MP0003011_delayed_dark_adaptation2.13168637
14MP0005275_abnormal_skin_tensile2.11923115
15MP0001835_abnormal_antigen_presentation2.02039660
16MP0001502_abnormal_circadian_rhythm1.94710711
17MP0001984_abnormal_olfaction1.92737505
18MP0005253_abnormal_eye_physiology1.91756517
19MP0004782_abnormal_surfactant_physiolog1.89478636
20MP0001968_abnormal_touch/_nociception1.89096202
21MP0001905_abnormal_dopamine_level1.87799479
22MP0003693_abnormal_embryo_hatching1.85479411
23MP0000685_abnormal_immune_system1.84530296
24MP0004381_abnormal_hair_follicle1.83177594
25MP0000647_abnormal_sebaceous_gland1.76564913
26MP0002938_white_spotting1.71540832
27MP0003880_abnormal_central_pattern1.69370976
28MP0003718_maternal_effect1.63368900
29MP0000427_abnormal_hair_cycle1.61722243
30MP0006072_abnormal_retinal_apoptosis1.61495174
31MP0004145_abnormal_muscle_electrophysio1.57565182
32MP0000383_abnormal_hair_follicle1.55997521
33MP0005075_abnormal_melanosome_morpholog1.54161611
34MP0002095_abnormal_skin_pigmentation1.50637855
35MP0009697_abnormal_copulation1.50149464
36MP0003646_muscle_fatigue1.46469148
37MP0004957_abnormal_blastocyst_morpholog1.44824997
38MP0005410_abnormal_fertilization1.42035284
39MP0005671_abnormal_response_to1.39367291
40MP0002102_abnormal_ear_morphology1.34501641
41MP0008875_abnormal_xenobiotic_pharmacok1.31777427
42MP0003111_abnormal_nucleus_morphology1.30330907
43MP0001529_abnormal_vocalization1.26143117
44MP0001348_abnormal_lacrimal_gland1.22865645
45MP0010094_abnormal_chromosome_stability1.21660121
46MP0006035_abnormal_mitochondrial_morpho1.18283278
47MP0003329_amyloid_beta_deposits1.15802588
48MP0001501_abnormal_sleep_pattern1.14617915
49MP0002405_respiratory_system_inflammati1.14098230
50MP0008007_abnormal_cellular_replicative1.13077578
51MP0005310_abnormal_salivary_gland1.12625613
52MP0006036_abnormal_mitochondrial_physio1.06463158
53MP0008932_abnormal_embryonic_tissue1.04916305
54MP0002132_abnormal_respiratory_system1.02590426
55MP0004043_abnormal_pH_regulation1.02025160
56MP0001986_abnormal_taste_sensitivity0.99355635
57MP0009764_decreased_sensitivity_to0.98682485
58MP0001727_abnormal_embryo_implantation0.96857737
59MP0002090_abnormal_vision0.96376358
60MP0003252_abnormal_bile_duct0.95280640
61MP0009053_abnormal_anal_canal0.94570622
62MP0003195_calcinosis0.93431812
63MP0003786_premature_aging0.92589248
64MP0009785_altered_susceptibility_to0.92503221
65MP0008770_decreased_survivor_rate0.90169697
66MP0002822_catalepsy0.88777845
67MP0003941_abnormal_skin_development0.86035806
68MP0002751_abnormal_autonomic_nervous0.85901834
69MP0002148_abnormal_hypersensitivity_rea0.85648295
70MP0002734_abnormal_mechanical_nocicepti0.85046490
71MP0005332_abnormal_amino_acid0.83955865
72MP0008260_abnormal_autophagy0.83635166
73MP0001243_abnormal_dermal_layer0.83040149
74MP0001764_abnormal_homeostasis0.81461289
75MP0002254_reproductive_system_inflammat0.80390371
76MP0008872_abnormal_physiological_respon0.77918490
77MP0010307_abnormal_tumor_latency0.77350671
78MP0008569_lethality_at_weaning0.76653595
79MP0009333_abnormal_splenocyte_physiolog0.75726781
80MP0003077_abnormal_cell_cycle0.73475390
81MP0004142_abnormal_muscle_tone0.71696298
82MP0002396_abnormal_hematopoietic_system0.67185679
83MP0010771_integument_phenotype0.66705774
84MP0001919_abnormal_reproductive_system0.66046334
85MP0000751_myopathy0.65382435
86MP0000749_muscle_degeneration0.63265482
87MP0001324_abnormal_eye_pigmentation0.62734753
88MP0001970_abnormal_pain_threshold0.62596978
89MP0002272_abnormal_nervous_system0.62130673
90MP0002653_abnormal_ependyma_morphology0.61320802
91MP0001958_emphysema0.60742351
92MP0002210_abnormal_sex_determination0.60356753
93MP0004215_abnormal_myocardial_fiber0.58935615
94MP0001929_abnormal_gametogenesis0.58831107
95MP0003806_abnormal_nucleotide_metabolis0.58427547
96MP0005636_abnormal_mineral_homeostasis0.56685892
97MP0008789_abnormal_olfactory_epithelium0.55666847
98MP0008873_increased_physiological_sensi0.54298935
99MP0004859_abnormal_synaptic_plasticity0.54203517
100MP0005171_absent_coat_pigmentation0.53796999

Predicted human phenotypes

RankGene SetZ-score
1Follicular hyperkeratosis (HP:0007502)5.19973661
2Congenital, generalized hypertrichosis (HP:0004540)4.91360518
3Acute necrotizing encephalopathy (HP:0006965)4.71191042
4Pili torti (HP:0003777)4.50978309
5Hepatocellular necrosis (HP:0001404)4.49405253
6Methylmalonic acidemia (HP:0002912)4.48240915
7Acute encephalopathy (HP:0006846)4.34772026
8Methylmalonic aciduria (HP:0012120)4.34184114
9Abnormal mitochondria in muscle tissue (HP:0008316)4.29746950
10Hepatic necrosis (HP:0002605)4.28740330
11Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.12319879
12Decreased activity of mitochondrial respiratory chain (HP:0008972)4.12319879
13Large for gestational age (HP:0001520)4.10932907
14Mitochondrial inheritance (HP:0001427)4.05798684
15Increased CSF lactate (HP:0002490)4.03299479
16Progressive macrocephaly (HP:0004481)3.65975505
17Duplicated collecting system (HP:0000081)3.52547662
18Abnormality of the pons (HP:0007361)3.50779625
19Neonatal respiratory distress (HP:0002643)3.36266467
20Increased serum lactate (HP:0002151)3.34093987
21Hypoglycemic coma (HP:0001325)3.32163164
22Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.16028395
23Increased hepatocellular lipid droplets (HP:0006565)3.15950781
24Microvesicular hepatic steatosis (HP:0001414)3.06748111
25Abnormality of the renal collecting system (HP:0004742)3.04181163
26Cerebral edema (HP:0002181)3.01867060
27Abnormality of homocysteine metabolism (HP:0010919)3.01774172
28Homocystinuria (HP:0002156)3.01774172
29Abnormality of the vitamin B12 metabolism (HP:0004341)3.00402366
30Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.90139817
31Abnormality of the anterior horn cell (HP:0006802)2.89927646
32Degeneration of anterior horn cells (HP:0002398)2.89927646
33Abnormality of methionine metabolism (HP:0010901)2.89226332
34Exercise intolerance (HP:0003546)2.88746290
35Abnormal hair laboratory examination (HP:0003328)2.87772494
36Sparse eyelashes (HP:0000653)2.80923444
37Lipid accumulation in hepatocytes (HP:0006561)2.80192998
38CNS demyelination (HP:0007305)2.80082858
39Lactic acidosis (HP:0003128)2.79663145
40Ketoacidosis (HP:0001993)2.78485741
41Abnormality of vitamin B metabolism (HP:0004340)2.73589432
42Cerebral hypomyelination (HP:0006808)2.72112891
43CNS hypomyelination (HP:0003429)2.69540754
44Lethargy (HP:0001254)2.64299428
45Abnormality of dicarboxylic acid metabolism (HP:0010995)2.57469042
46Dicarboxylic aciduria (HP:0003215)2.57469042
47Respiratory failure (HP:0002878)2.57026769
48Optic disc pallor (HP:0000543)2.49505158
49Thyroid-stimulating hormone excess (HP:0002925)2.46397428
50Oral leukoplakia (HP:0002745)2.40037370
51Medial flaring of the eyebrow (HP:0010747)2.37823685
52Hypoplasia of the capital femoral epiphysis (HP:0003090)2.34536523
53Brittle hair (HP:0002299)2.33261602
54Type I transferrin isoform profile (HP:0003642)2.27938482
55Abnormality of aspartate family amino acid metabolism (HP:0010899)2.26470315
56Hyperglycinemia (HP:0002154)2.23000337
57Emotional lability (HP:0000712)2.21912466
58Hypoglycemic seizures (HP:0002173)2.21188154
59Leukodystrophy (HP:0002415)2.19420604
60Action tremor (HP:0002345)2.15893583
61Generalized aminoaciduria (HP:0002909)2.14700897
62Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.14203844
63Spastic tetraparesis (HP:0001285)2.13675921
64Woolly hair (HP:0002224)2.13320258
653-Methylglutaconic aciduria (HP:0003535)2.12435691
66Pancytopenia (HP:0001876)2.06073060
67Reticulocytopenia (HP:0001896)2.05190530
68Premature ovarian failure (HP:0008209)2.02768385
69Ulnar claw (HP:0001178)2.02319392
70Respiratory difficulties (HP:0002880)1.99915044
71Abnormal number of erythroid precursors (HP:0012131)1.98973785
72Blindness (HP:0000618)1.97726683
73Hyperglycinuria (HP:0003108)1.97550227
74Atrophy/Degeneration involving motor neurons (HP:0007373)1.96143569
75Renal Fanconi syndrome (HP:0001994)1.95776365
76Hypoplasia of the pons (HP:0012110)1.95045568
77Increased intramyocellular lipid droplets (HP:0012240)1.93282082
78Progressive inability to walk (HP:0002505)1.92178508
79Ragged-red muscle fibers (HP:0003200)1.92154897
80Exercise-induced muscle cramps (HP:0003710)1.89828900
81Cellular immunodeficiency (HP:0005374)1.88425179
82Abnormality of glycine metabolism (HP:0010895)1.85988116
83Abnormality of serine family amino acid metabolism (HP:0010894)1.85988116
84Hyperinsulinemic hypoglycemia (HP:0000825)1.85222892
85Short 5th finger (HP:0009237)1.83094724
86Chronic bronchitis (HP:0004469)1.80784842
87Ketosis (HP:0001946)1.80485968
88Abnormality of urine glucose concentration (HP:0011016)1.78953863
89Glycosuria (HP:0003076)1.78953863
90Ureteral duplication (HP:0000073)1.78368275
91Inability to walk (HP:0002540)1.77500180
92Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.75801937
93Gliosis (HP:0002171)1.74159504
94Gait imbalance (HP:0002141)1.71759815
95Congenital primary aphakia (HP:0007707)1.70393066
96Abnormality of serum amino acid levels (HP:0003112)1.69862116
97Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.68301522
98Absent epiphyses (HP:0010577)1.68301522
99Attenuation of retinal blood vessels (HP:0007843)1.67932337
100Postnatal microcephaly (HP:0005484)1.67238111

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME13.30414309
2NEK62.84626943
3VRK22.79558171
4TSSK62.77541145
5TXK2.67809792
6STK162.63075606
7MKNK22.50804245
8EIF2AK32.35513062
9MKNK12.16584311
10BMPR1B2.07703180
11PDK210.8898948
12BUB11.98630108
13TRIM281.95086583
14NEK11.87276081
15CCNB11.81116191
16SRPK11.76994584
17MAPKAPK31.75856823
18PBK1.65610383
19TLK11.51075717
20VRK11.45703027
21EIF2AK11.25611433
22MST41.15525181
23NUAK11.12779444
24PASK1.10059094
25NTRK21.08823691
26BCKDK1.06283578
27MAPK70.95516004
28WNK30.92602083
29ADRBK20.91617347
30PLK30.90323654
31PKN20.88719267
32GRK10.86839558
33PINK10.85050771
34PLK40.84700287
35MAPK120.83369145
36PRKCG0.79809064
37EIF2AK20.79665930
38ZAK0.78805002
39WNK40.76970038
40BCR0.75408781
41PIM20.75036113
42ALK0.74579284
43DAPK10.64735612
44PHKG20.57881831
45PHKG10.57881831
46FGFR10.54907811
47DYRK1A0.54357553
48MAPKAPK50.54351259
49MAP4K20.54157468
50TTK0.54119437
51RPS6KA50.53696994
52CSNK1G10.52203642
53TEC0.48685255
54TGFBR10.48140045
55FGR0.46116557
56CDK80.43699765
57STK40.42663969
58FLT30.41436206
59FRK0.41162531
60NME20.38991854
61PRKG20.38796092
62PLK20.38374626
63INSRR0.38136192
64PLK10.36550534
65STK390.35872881
66BRD40.35841309
67PTK2B0.35816418
68PRKCI0.35621492
69MUSK0.35044775
70CSNK1G30.34949805
71DYRK20.33394181
72CSNK1A1L0.32629929
73PAK30.32070379
74CDC70.31925006
75SIK30.31211181
76CSNK2A20.29697351
77STK380.28903395
78PDK10.28104228
79ATR0.27874114
80AURKA0.26014956
81PIK3CA0.24959052
82CAMK2A0.23921786
83PRKCH0.23627419
84CSNK1E0.21997693
85ADRBK10.21643760
86CSNK2A10.21464094
87PRKACA0.20259728
88CSNK1A10.20031937
89MAP3K90.19603951
90MARK30.17404292
91ERBB40.17190010
92PRKCE0.17144708
93PDPK10.16539722
94TESK20.16520936
95TIE10.16284730
96PAK60.15972479
97PRKCA0.14910171
98MAP3K40.14896260
99PRKACG0.14782471
100LRRK20.14189948

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.93019906
2RNA polymerase_Homo sapiens_hsa030203.34097845
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.24529710
4Oxidative phosphorylation_Homo sapiens_hsa001903.15296179
5Protein export_Homo sapiens_hsa030602.68859822
6One carbon pool by folate_Homo sapiens_hsa006702.67173759
7Parkinsons disease_Homo sapiens_hsa050122.42299189
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.39802561
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.37277264
10Propanoate metabolism_Homo sapiens_hsa006402.30561928
11Fatty acid elongation_Homo sapiens_hsa000622.29976720
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.11572838
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.07663407
14Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.06605984
15Pyruvate metabolism_Homo sapiens_hsa006202.04438072
16Collecting duct acid secretion_Homo sapiens_hsa049661.98593865
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.89253135
18Ribosome_Homo sapiens_hsa030101.78321652
19Huntingtons disease_Homo sapiens_hsa050161.75084898
20Cysteine and methionine metabolism_Homo sapiens_hsa002701.59305997
21Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.56583326
22Alzheimers disease_Homo sapiens_hsa050101.55572848
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.54676501
24Pyrimidine metabolism_Homo sapiens_hsa002401.44765787
25Basal transcription factors_Homo sapiens_hsa030221.35566024
26Mismatch repair_Homo sapiens_hsa034301.34508816
27beta-Alanine metabolism_Homo sapiens_hsa004101.34435527
28Purine metabolism_Homo sapiens_hsa002301.34214921
29RNA degradation_Homo sapiens_hsa030181.34142528
30Spliceosome_Homo sapiens_hsa030401.33648154
31Biosynthesis of amino acids_Homo sapiens_hsa012301.30879854
32Homologous recombination_Homo sapiens_hsa034401.22535362
33RNA transport_Homo sapiens_hsa030131.21701401
34Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.19002910
35Carbon metabolism_Homo sapiens_hsa012001.17455961
36Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.15303648
37Nucleotide excision repair_Homo sapiens_hsa034201.12569329
38Butanoate metabolism_Homo sapiens_hsa006501.06028972
39Fatty acid metabolism_Homo sapiens_hsa012121.04109474
40Regulation of autophagy_Homo sapiens_hsa041401.02418718
41Cardiac muscle contraction_Homo sapiens_hsa042601.01136638
42Renin-angiotensin system_Homo sapiens_hsa046140.97413650
43Rheumatoid arthritis_Homo sapiens_hsa053230.95706036
44Peroxisome_Homo sapiens_hsa041460.93059600
45Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.88498867
46Nitrogen metabolism_Homo sapiens_hsa009100.88051014
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.86474989
48Tryptophan metabolism_Homo sapiens_hsa003800.85439240
49DNA replication_Homo sapiens_hsa030300.83413809
50Metabolic pathways_Homo sapiens_hsa011000.79789984
51Cyanoamino acid metabolism_Homo sapiens_hsa004600.77218967
52Fatty acid degradation_Homo sapiens_hsa000710.76792835
53Vibrio cholerae infection_Homo sapiens_hsa051100.76615956
54Primary bile acid biosynthesis_Homo sapiens_hsa001200.75067896
55Glutathione metabolism_Homo sapiens_hsa004800.74630915
56Arginine and proline metabolism_Homo sapiens_hsa003300.68174419
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.67986141
58Fanconi anemia pathway_Homo sapiens_hsa034600.65929846
59Synaptic vesicle cycle_Homo sapiens_hsa047210.65670665
602-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.63200224
61N-Glycan biosynthesis_Homo sapiens_hsa005100.62983912
62Folate biosynthesis_Homo sapiens_hsa007900.62571164
63ABC transporters_Homo sapiens_hsa020100.62100017
64Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.58855429
65Glycerolipid metabolism_Homo sapiens_hsa005610.58077168
66Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.55249210
67alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53798103
68Olfactory transduction_Homo sapiens_hsa047400.53574207
69Phototransduction_Homo sapiens_hsa047440.51907875
70SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50656342
71Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.50234282
72Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.45208903
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39071724
74Histidine metabolism_Homo sapiens_hsa003400.38079826
75Fructose and mannose metabolism_Homo sapiens_hsa000510.37937141
76Asthma_Homo sapiens_hsa053100.37161219
77Lysine degradation_Homo sapiens_hsa003100.35701741
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35025621
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33855816
80Type I diabetes mellitus_Homo sapiens_hsa049400.32952308
81Chemical carcinogenesis_Homo sapiens_hsa052040.32947562
82Epstein-Barr virus infection_Homo sapiens_hsa051690.32805529
83Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.31431155
84Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.30432026
85Linoleic acid metabolism_Homo sapiens_hsa005910.30338982
86Hedgehog signaling pathway_Homo sapiens_hsa043400.29873354
87Hematopoietic cell lineage_Homo sapiens_hsa046400.28879351
88Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.28835077
89Ether lipid metabolism_Homo sapiens_hsa005650.28823702
90Primary immunodeficiency_Homo sapiens_hsa053400.27976443
91Vitamin digestion and absorption_Homo sapiens_hsa049770.27498562
92Maturity onset diabetes of the young_Homo sapiens_hsa049500.26470851
93Base excision repair_Homo sapiens_hsa034100.24262181
94Sulfur relay system_Homo sapiens_hsa041220.22924557
95Non-homologous end-joining_Homo sapiens_hsa034500.20737753
96Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.19882707
97Antigen processing and presentation_Homo sapiens_hsa046120.19614821
98Jak-STAT signaling pathway_Homo sapiens_hsa046300.18884316
99Allograft rejection_Homo sapiens_hsa053300.18675253
100Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.17403097

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