PFN4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)9.53300020
2acrosome reaction (GO:0007340)9.15335442
3axonemal dynein complex assembly (GO:0070286)9.02596123
4multicellular organism reproduction (GO:0032504)8.62430826
5epithelial cilium movement (GO:0003351)8.45017537
6sperm-egg recognition (GO:0035036)8.37286741
7acrosome assembly (GO:0001675)7.92961537
8motile cilium assembly (GO:0044458)7.92311836
9cell wall macromolecule catabolic process (GO:0016998)7.81651209
10cell wall macromolecule metabolic process (GO:0044036)7.81651209
11plasma membrane fusion (GO:0045026)7.79010261
12binding of sperm to zona pellucida (GO:0007339)7.74047346
13male meiosis (GO:0007140)7.64585968
14spermatid development (GO:0007286)7.58547004
15cilium movement (GO:0003341)7.45072002
16cell-cell recognition (GO:0009988)7.40945914
17synaptonemal complex organization (GO:0070193)7.38574995
18regulation of cilium movement (GO:0003352)7.35865956
19synaptonemal complex assembly (GO:0007130)7.03055655
20reproduction (GO:0000003)7.00919970
21epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.90173075
22negative regulation of inclusion body assembly (GO:0090084)6.33970432
23DNA methylation involved in gamete generation (GO:0043046)6.22537799
24single fertilization (GO:0007338)6.06508103
25sperm capacitation (GO:0048240)5.88709216
26fertilization (GO:0009566)5.37317956
27male meiosis I (GO:0007141)5.35535880
28spermatogenesis (GO:0007283)5.25168780
29male gamete generation (GO:0048232)5.23839340
30regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022355.15224025
31regulation of inclusion body assembly (GO:0090083)5.04390129
32calcium ion-dependent exocytosis (GO:0017156)4.97205774
33regulation of cardioblast proliferation (GO:0003264)4.96580992
34regulation of secondary heart field cardioblast proliferation (GO:0003266)4.96580992
35microtubule depolymerization (GO:0007019)4.93174080
36gamete generation (GO:0007276)4.90325247
37microtubule severing (GO:0051013)4.89024451
38ventricular system development (GO:0021591)4.72025810
39regulation of microtubule-based movement (GO:0060632)4.61889029
40chromosome organization involved in meiosis (GO:0070192)4.60053501
41nephron tubule formation (GO:0072079)4.49657606
42meiotic nuclear division (GO:0007126)4.48464912
43cell morphogenesis involved in neuron differentiation (GO:0048667)4.45695402
44cullin deneddylation (GO:0010388)4.43428753
45negative regulation of mesenchymal cell apoptotic process (GO:2001054)4.40091254
46germ cell development (GO:0007281)4.39132981
47meiosis I (GO:0007127)4.36144254
48positive regulation of male gonad development (GO:2000020)4.35569085
49neuron fate determination (GO:0048664)4.33191613
50cellular process involved in reproduction in multicellular organism (GO:0022412)4.31941309
51regulation of cell proliferation involved in heart morphogenesis (GO:2000136)4.28792062
52protein K6-linked ubiquitination (GO:0085020)4.25550799
53limb bud formation (GO:0060174)4.17620739
54cell recognition (GO:0008037)4.15968860
55establishment of nucleus localization (GO:0040023)4.13932544
56positive regulation of growth hormone secretion (GO:0060124)4.13790645
57protein polyglutamylation (GO:0018095)4.08400238
58meiotic cell cycle (GO:0051321)4.08241774
59protein localization to cilium (GO:0061512)4.04333488
60organic cation transport (GO:0015695)3.93745255
61axoneme assembly (GO:0035082)3.87128204
62multicellular organismal reproductive process (GO:0048609)3.85452737
63protein deneddylation (GO:0000338)3.83777888
64regulation of meiosis I (GO:0060631)3.83492724
65response to pheromone (GO:0019236)3.82832185
66spermatid nucleus differentiation (GO:0007289)3.81582208
67adult feeding behavior (GO:0008343)3.78758975
68radial glial cell differentiation (GO:0060019)3.76705599
69left/right pattern formation (GO:0060972)3.74353970
70otic vesicle formation (GO:0030916)3.70972570
71dopaminergic neuron differentiation (GO:0071542)3.69988574
72positive regulation of extracellular matrix organization (GO:1903055)3.65429913
73regulation of male gonad development (GO:2000018)3.49909759
74growth hormone secretion (GO:0030252)3.48895593
75parental behavior (GO:0060746)3.47771876
76intraciliary transport (GO:0042073)3.45600859
77seminiferous tubule development (GO:0072520)3.45593216
78fucose catabolic process (GO:0019317)3.43621708
79L-fucose metabolic process (GO:0042354)3.43621708
80L-fucose catabolic process (GO:0042355)3.43621708
81startle response (GO:0001964)3.43450356
82left/right axis specification (GO:0070986)3.41038029
83maternal behavior (GO:0042711)3.38809583
84establishment of protein localization to mitochondrial membrane (GO:0090151)3.37761440
85protein targeting to Golgi (GO:0000042)3.36051005
86establishment of protein localization to Golgi (GO:0072600)3.32319314
87ether metabolic process (GO:0018904)3.31359340
88regulation of mesenchymal cell apoptotic process (GO:2001053)3.30971952
89norepinephrine metabolic process (GO:0042415)3.29911655
90microtubule polymerization or depolymerization (GO:0031109)3.27240770
91protein localization to Golgi apparatus (GO:0034067)3.26487693
92dopamine transport (GO:0015872)3.23109568
93positive regulation of mitochondrial fission (GO:0090141)3.22101487
94regulation of type B pancreatic cell apoptotic process (GO:2000674)3.21264897
95toxin metabolic process (GO:0009404)3.20695718
96regulation of glucokinase activity (GO:0033131)3.18581639
97regulation of hexokinase activity (GO:1903299)3.18581639
98response to redox state (GO:0051775)3.15958297
99endocrine pancreas development (GO:0031018)3.15176218
100resolution of meiotic recombination intermediates (GO:0000712)3.09427494
101regulation of heart morphogenesis (GO:2000826)3.08719765
102neuron projection extension involved in neuron projection guidance (GO:1902284)3.06354941
103axon extension involved in axon guidance (GO:0048846)3.06354941
104microtubule-based movement (GO:0007018)3.06325705
105retrograde transport, vesicle recycling within Golgi (GO:0000301)3.03988599
106smoothened signaling pathway (GO:0007224)3.02397411
107vocalization behavior (GO:0071625)3.02243916
108cilium morphogenesis (GO:0060271)3.01442155
109type B pancreatic cell development (GO:0003323)2.99872039
110negative regulation of organelle assembly (GO:1902116)2.99518416
111cilium organization (GO:0044782)2.99412589
112pancreas development (GO:0031016)2.99376183
113ganglion development (GO:0061548)2.98565990
114multicellular organismal development (GO:0007275)2.97274924
115nonmotile primary cilium assembly (GO:0035058)2.97122892
116meiotic cell cycle process (GO:1903046)2.95415257
117neural crest cell development (GO:0014032)2.95319517
118gene silencing by RNA (GO:0031047)2.94091959
119glycerol ether metabolic process (GO:0006662)2.92821802
120cilium assembly (GO:0042384)2.90602257
121nucleoside diphosphate phosphorylation (GO:0006165)2.89078209
122polyol catabolic process (GO:0046174)2.88196592
123axon ensheathment in central nervous system (GO:0032291)2.87773932
124central nervous system myelination (GO:0022010)2.87773932
125chaperone-mediated protein complex assembly (GO:0051131)2.87197090
126organelle disassembly (GO:1903008)2.87100573
127multicellular organismal reproductive behavior (GO:0033057)2.83966883
128regulation of podosome assembly (GO:0071801)2.79448883
129protein refolding (GO:0042026)2.77047060
130meiotic chromosome segregation (GO:0045132)2.75674443
131phagocytosis, recognition (GO:0006910)2.74742321
132cellular component assembly involved in morphogenesis (GO:0010927)2.74709478
133nucleus localization (GO:0051647)2.74679290
134notochord development (GO:0030903)2.72335095
135nephron tubule morphogenesis (GO:0072078)2.72298561
136nephron epithelium morphogenesis (GO:0072088)2.72298561
137embryonic epithelial tube formation (GO:0001838)2.71752104
138Sertoli cell development (GO:0060009)2.71333169
139sex differentiation (GO:0007548)2.69193421
140chondrocyte proliferation (GO:0035988)2.68588369
141retinal ganglion cell axon guidance (GO:0031290)2.67303404
142stem cell development (GO:0048864)2.66810249
143negative regulation of oligodendrocyte differentiation (GO:0048715)2.64750821
144regulation of spindle checkpoint (GO:0090231)2.63706301
145lactate metabolic process (GO:0006089)2.63485478
146endocardial cushion morphogenesis (GO:0003203)2.62407847
147single strand break repair (GO:0000012)2.62197117
148regulation of growth hormone secretion (GO:0060123)2.61412850
149neural tube formation (GO:0001841)2.61173463
150negative regulation of protein autophosphorylation (GO:0031953)2.60828779
151GTP biosynthetic process (GO:0006183)2.60815329
152axis elongation (GO:0003401)2.59883253
153photoreceptor cell differentiation (GO:0046530)2.58188106
154eye photoreceptor cell differentiation (GO:0001754)2.58188106
155mesenchymal-epithelial cell signaling (GO:0060638)2.58047539
156male sex determination (GO:0030238)2.57099770
157chromosome condensation (GO:0030261)2.56282259
158heart process (GO:0003015)2.56024615
159alditol metabolic process (GO:0019400)2.54968473
160neuron cell-cell adhesion (GO:0007158)2.53342043
161mitochondrial fission (GO:0000266)2.53325172
162centriole replication (GO:0007099)2.51664444
163DNA packaging (GO:0006323)2.51521984
164monoubiquitinated protein deubiquitination (GO:0035520)2.49703133
165synapsis (GO:0007129)2.45123470
166regulation of acrosome reaction (GO:0060046)2.44334500
167glycerol metabolic process (GO:0006071)2.42532155
168peptidyl-glutamic acid modification (GO:0018200)2.40021279
169locomotory exploration behavior (GO:0035641)2.39717456
170glycolytic process (GO:0006096)2.38271642
171genitalia morphogenesis (GO:0035112)2.36429020
172protein localization to synapse (GO:0035418)2.35027918
173centriole assembly (GO:0098534)2.32790864
174protein K11-linked deubiquitination (GO:0035871)2.29130510
175appendage development (GO:0048736)2.27319588
176limb development (GO:0060173)2.27319588
177mitochondrion degradation (GO:0000422)2.23501707
178exploration behavior (GO:0035640)2.20815358
179calcium ion import (GO:0070509)2.18786436
180cilium or flagellum-dependent cell motility (GO:0001539)10.5324665
181sperm motility (GO:0030317)10.1524975
182fusion of sperm to egg plasma membrane (GO:0007342)10.1049523

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse6.60465183
2EZH2_22144423_ChIP-Seq_EOC_Human5.94206465
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.52970994
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.01140198
5IGF1R_20145208_ChIP-Seq_DFB_Human2.90107406
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.87483658
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.65966517
8GATA1_22025678_ChIP-Seq_K562_Human2.37145717
9ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.37142010
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.25869837
11STAT6_21828071_ChIP-Seq_BEAS2B_Human2.24534094
12PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.18329899
13BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.17030000
14PIAS1_25552417_ChIP-Seq_VCAP_Human2.10793042
15VDR_22108803_ChIP-Seq_LS180_Human2.10282396
16TAF15_26573619_Chip-Seq_HEK293_Human2.06746432
17RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.06080489
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.05228851
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.05171002
20GATA1_26923725_Chip-Seq_HPCs_Mouse2.02516968
21ZNF274_21170338_ChIP-Seq_K562_Hela2.01819596
22CTBP2_25329375_ChIP-Seq_LNCAP_Human1.99674325
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.97359912
24REST_21632747_ChIP-Seq_MESCs_Mouse1.91227201
25EWS_26573619_Chip-Seq_HEK293_Human1.91218700
26CBX2_27304074_Chip-Seq_ESCs_Mouse1.89155156
27ZFP57_27257070_Chip-Seq_ESCs_Mouse1.87382026
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.85030857
29GBX2_23144817_ChIP-Seq_PC3_Human1.81067909
30AR_21572438_ChIP-Seq_LNCaP_Human1.76523731
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.72355797
32NOTCH1_21737748_ChIP-Seq_TLL_Human1.65251508
33RNF2_27304074_Chip-Seq_NSC_Mouse1.61650771
34NR3C1_21868756_ChIP-Seq_MCF10A_Human1.61244110
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.60702446
36ELK1_19687146_ChIP-ChIP_HELA_Human1.59031144
37MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.57450862
38* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.55271945
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.53738870
40FUS_26573619_Chip-Seq_HEK293_Human1.53229293
41TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.52188393
42TAL1_26923725_Chip-Seq_HPCs_Mouse1.49385023
43TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.48430288
44NANOG_18555785_Chip-Seq_ESCs_Mouse1.46939653
45KDM2B_26808549_Chip-Seq_REH_Human1.46808032
46ELK4_26923725_Chip-Seq_MESODERM_Mouse1.46794750
47EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.44668117
48MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.44418893
49CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.44356702
50SUZ12_27294783_Chip-Seq_NPCs_Mouse1.40795350
51CDX2_19796622_ChIP-Seq_MESCs_Mouse1.40746285
52NFE2_27457419_Chip-Seq_LIVER_Mouse1.40281644
53* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.38444194
54OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38171411
55POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.37310970
56TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37310970
57SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36826335
58ER_23166858_ChIP-Seq_MCF-7_Human1.35640007
59CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.33752180
60TP53_18474530_ChIP-ChIP_U2OS_Human1.33682654
61CBP_20019798_ChIP-Seq_JUKART_Human1.33117111
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33117111
63SMAD4_21799915_ChIP-Seq_A2780_Human1.32361865
64SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.29041731
65TP53_22573176_ChIP-Seq_HFKS_Human1.28585100
66RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.28408531
67MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.28124362
68EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.27859987
69PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27499041
70FLI1_21867929_ChIP-Seq_TH2_Mouse1.26678383
71NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.26256978
72NRF2_20460467_ChIP-Seq_MEFs_Mouse1.26256978
73SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.25648740
74* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.24608201
75* KAP1_22055183_ChIP-Seq_ESCs_Mouse1.23294271
76PHF8_20622853_ChIP-Seq_HELA_Human1.21763975
77POU3F2_20337985_ChIP-ChIP_501MEL_Human1.21740582
78CMYC_18555785_Chip-Seq_ESCs_Mouse1.21695540
79WDR5_24793694_ChIP-Seq_LNCAP_Human1.20555983
80REST_18959480_ChIP-ChIP_MESCs_Mouse1.20463168
81BCAT_22108803_ChIP-Seq_LS180_Human1.20019119
82CJUN_26792858_Chip-Seq_BT549_Human1.19977754
83HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.19663107
84TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19490710
85SUZ12_27294783_Chip-Seq_ESCs_Mouse1.19406145
86ARNT_22903824_ChIP-Seq_MCF-7_Human1.18949584
87STAT1_17558387_ChIP-Seq_HELA_Human1.18851760
88UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18644178
89PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.18596254
90IRF1_19129219_ChIP-ChIP_H3396_Human1.18102611
91ETV1_20927104_ChIP-Seq_GIST48_Human1.16924831
92P53_22387025_ChIP-Seq_ESCs_Mouse1.16135892
93GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.16090123
94FOXA1_27270436_Chip-Seq_PROSTATE_Human1.15969860
95FOXA1_25329375_ChIP-Seq_VCAP_Human1.15969860
96TCF4_22108803_ChIP-Seq_LS180_Human1.15841864
97SOX2_21211035_ChIP-Seq_LN229_Gbm1.15436792
98PCGF2_27294783_Chip-Seq_NPCs_Mouse1.15321607
99RBPJ_21746931_ChIP-Seq_IB4_Human1.14391389
100FOXM1_26456572_ChIP-Seq_MCF-7_Human1.13479694
101E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.13355884
102CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.13199893
103HNFA_21074721_ChIP-Seq_CACO-2_Human1.13174428
104SMAD3_21741376_ChIP-Seq_EPCs_Human1.12617313
105EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.12518597
106TCF4_23295773_ChIP-Seq_U87_Human1.12409908
107CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.12274571
108P300_18555785_Chip-Seq_ESCs_Mouse1.12028076
109STAT3_18555785_Chip-Seq_ESCs_Mouse1.11946311
110BMI1_23680149_ChIP-Seq_NPCS_Mouse1.11942494
111AHR_22903824_ChIP-Seq_MCF-7_Human1.10516896
112P300_19829295_ChIP-Seq_ESCs_Human1.09839416
113SUZ12_18555785_Chip-Seq_ESCs_Mouse1.09751791
114HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.09425831
115GABP_17652178_ChIP-ChIP_JURKAT_Human1.09146082
116EZH2_27294783_Chip-Seq_NPCs_Mouse1.08663013
117OCT4_18555785_Chip-Seq_ESCs_Mouse1.08243548
118E2F1_18555785_Chip-Seq_ESCs_Mouse1.07420178
119TP53_16413492_ChIP-PET_HCT116_Human1.07172748
120SMAD4_21741376_ChIP-Seq_EPCs_Human1.06618799
121EZH2_27294783_Chip-Seq_ESCs_Mouse1.06541165
122CRX_20693478_ChIP-Seq_RETINA_Mouse1.06405474
123TBX3_20139965_ChIP-Seq_MESCs_Mouse1.06375778
124CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.05992400
125RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.05840550
126SOX9_26525672_Chip-Seq_HEART_Mouse1.05688805
127NFYB_21822215_ChIP-Seq_K562_Human1.05409872
128SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04967605
129RUNX2_22187159_ChIP-Seq_PCA_Human1.04911918
130CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04746721
131KLF4_18555785_Chip-Seq_ESCs_Mouse1.04619703
132SOX2_19829295_ChIP-Seq_ESCs_Human1.04085298
133NANOG_19829295_ChIP-Seq_ESCs_Human1.04085298
134AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03718258
135KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.03191374
136HTT_18923047_ChIP-ChIP_STHdh_Human1.02984367
137TBL1_22424771_ChIP-Seq_293T_Human1.01819863
138MTF2_20144788_ChIP-Seq_MESCs_Mouse1.01303477
139SOX2_18555785_Chip-Seq_ESCs_Mouse1.00507794
140TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99866128
141* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.98463332
142CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97925151
143STAT3_23295773_ChIP-Seq_U87_Human0.95951120
144RNF2_27304074_Chip-Seq_ESCs_Mouse0.95830504
145RUNX1_27457419_Chip-Seq_LIVER_Mouse0.95179901
146AR_25329375_ChIP-Seq_VCAP_Human0.95008951
147ESRRB_18555785_Chip-Seq_ESCs_Mouse0.95006977
148OCT4_21477851_ChIP-Seq_ESCs_Mouse0.94765405
149CTCF_18555785_Chip-Seq_ESCs_Mouse0.94159560
150GATA3_21867929_ChIP-Seq_TH1_Mouse0.94067365
151GF1_26923725_Chip-Seq_HPCs_Mouse0.93691097
152SOX2_22085726_ChIP-Seq_NPCs_Mouse0.93177966
153FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93099092

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009780_abnormal_chondrocyte_physiolo4.97509529
2MP0003698_abnormal_male_reproductive4.51315905
3MP0008877_abnormal_DNA_methylation4.33812276
4MP0001929_abnormal_gametogenesis4.19243688
5MP0002928_abnormal_bile_duct3.62521772
6MP0003283_abnormal_digestive_organ3.28162554
7MP0003880_abnormal_central_pattern2.92608035
8MP0002210_abnormal_sex_determination2.88848102
9MP0002837_dystrophic_cardiac_calcinosis2.76768590
10MP0002161_abnormal_fertility/fecundity2.58509939
11MP0002653_abnormal_ependyma_morphology2.51596128
12MP0000569_abnormal_digit_pigmentation2.44649318
13MP0002638_abnormal_pupillary_reflex2.42400366
14MP0005084_abnormal_gallbladder_morpholo2.39872019
15MP0000749_muscle_degeneration2.37755360
16MP0001145_abnormal_male_reproductive2.37351457
17MP0000372_irregular_coat_pigmentation2.31338775
18MP0004270_analgesia2.30666013
19MP0000653_abnormal_sex_gland2.22594274
20MP0001529_abnormal_vocalization2.21891640
21MP0004859_abnormal_synaptic_plasticity2.20131216
22MP0009046_muscle_twitch2.16523840
23MP0005503_abnormal_tendon_morphology2.14278069
24MP0004084_abnormal_cardiac_muscle2.05384539
25MP0003646_muscle_fatigue2.05316572
26MP0004215_abnormal_myocardial_fiber2.01838191
27MP0005410_abnormal_fertilization10.8640207
28MP0003329_amyloid_beta_deposits1.98968806
29MP0003635_abnormal_synaptic_transmissio1.95704901
30MP0005248_abnormal_Harderian_gland1.93901282
31MP0001486_abnormal_startle_reflex1.79270420
32MP0005646_abnormal_pituitary_gland1.74339653
33MP0009745_abnormal_behavioral_response1.67092560
34MP0002063_abnormal_learning/memory/cond1.59502632
35MP0002572_abnormal_emotion/affect_behav1.57105518
36MP0001984_abnormal_olfaction1.54680321
37MP0002272_abnormal_nervous_system1.54313703
38MP0008775_abnormal_heart_ventricle1.51902363
39MP0001968_abnormal_touch/_nociception1.50111100
40MP0003195_calcinosis1.49382572
41MP0002064_seizures1.48838976
42MP0009250_abnormal_appendicular_skeleto1.47970745
43MP0002233_abnormal_nose_morphology1.47179966
44MP0006054_spinal_hemorrhage1.45423209
45MP0005171_absent_coat_pigmentation1.45340363
46MP0000647_abnormal_sebaceous_gland1.44196802
47MP0002090_abnormal_vision1.42376595
48MP0001440_abnormal_grooming_behavior1.41583461
49MP0005623_abnormal_meninges_morphology1.40845342
50MP0002736_abnormal_nociception_after1.40598620
51MP0002102_abnormal_ear_morphology1.40197435
52MP0002734_abnormal_mechanical_nocicepti1.40151939
53MP0002160_abnormal_reproductive_system1.39590792
54MP0001905_abnormal_dopamine_level1.37673795
55MP0002938_white_spotting1.36346464
56MP0005360_urolithiasis1.34158929
57MP0003937_abnormal_limbs/digits/tail_de1.32323954
58MP0000427_abnormal_hair_cycle1.31781020
59MP0003718_maternal_effect1.31345092
60MP0002282_abnormal_trachea_morphology1.30801605
61MP0005423_abnormal_somatic_nervous1.29742950
62MP0000778_abnormal_nervous_system1.28441843
63MP0006276_abnormal_autonomic_nervous1.23973312
64MP0010234_abnormal_vibrissa_follicle1.22305791
65MP0008007_abnormal_cellular_replicative1.21738827
66MP0008058_abnormal_DNA_repair1.20180025
67MP0005551_abnormal_eye_electrophysiolog1.18232133
68MP0008875_abnormal_xenobiotic_pharmacok1.15888701
69MP0005379_endocrine/exocrine_gland_phen1.14253717
70MP0002067_abnormal_sensory_capabilities1.13722362
71MP0003136_yellow_coat_color1.12408624
72MP0000383_abnormal_hair_follicle1.11692846
73MP0000534_abnormal_ureter_morphology1.11325487
74MP0001958_emphysema1.10917663
75MP0008438_abnormal_cutaneous_collagen1.10056640
76MP0010678_abnormal_skin_adnexa1.09624719
77MP0004742_abnormal_vestibular_system1.09404269
78MP0002269_muscular_atrophy1.07328701
79MP0003806_abnormal_nucleotide_metabolis1.06236349
80MP0004782_abnormal_surfactant_physiolog1.05934952
81MP0001502_abnormal_circadian_rhythm1.05610085
82MP0009697_abnormal_copulation1.04983775
83MP0000920_abnormal_myelination1.04377554
84MP0003252_abnormal_bile_duct1.04182155
85MP0005330_cardiomyopathy1.00793537
86MP0000358_abnormal_cell_content/1.00173207
87MP0001286_abnormal_eye_development1.00105811
88MP0005167_abnormal_blood-brain_barrier0.99752537
89MP0010030_abnormal_orbit_morphology0.98381098
90MP0004924_abnormal_behavior0.97454261
91MP0005386_behavior/neurological_phenoty0.97454261
92MP0003950_abnormal_plasma_membrane0.96872448
93MP0001963_abnormal_hearing_physiology0.94459128
94MP0002909_abnormal_adrenal_gland0.94242746
95MP0002152_abnormal_brain_morphology0.94199305
96MP0000631_abnormal_neuroendocrine_gland0.93872470
97MP0004885_abnormal_endolymph0.93840761
98MP0001485_abnormal_pinna_reflex0.93380587
99MP0002882_abnormal_neuron_morphology0.93219406
100MP0000955_abnormal_spinal_cord0.92380615
101MP0004233_abnormal_muscle_weight0.90664926
102MP0006072_abnormal_retinal_apoptosis0.89919416
103MP0003632_abnormal_nervous_system0.89691760
104MP0001970_abnormal_pain_threshold0.89141129
105MP0008569_lethality_at_weaning0.88871525
106MP0010386_abnormal_urinary_bladder0.88372490
107MP0004145_abnormal_muscle_electrophysio0.88241050
108MP0000751_myopathy0.88175506
109MP0008057_abnormal_DNA_replication0.87718252
110MP0002066_abnormal_motor_capabilities/c0.86666965
111MP0005451_abnormal_body_composition0.86587527
112MP0002229_neurodegeneration0.86091815
113MP0002557_abnormal_social/conspecific_i0.85142648
114MP0000013_abnormal_adipose_tissue0.84835090
115MP0000604_amyloidosis0.84813609
116MP0003631_nervous_system_phenotype0.84482366
117MP0002733_abnormal_thermal_nociception0.84246809
118MP0000538_abnormal_urinary_bladder0.83904103
119MP0004142_abnormal_muscle_tone0.82896360
120MP0003634_abnormal_glial_cell0.82772402
121MP0008995_early_reproductive_senescence0.82149562
122MP0000537_abnormal_urethra_morphology0.81209207
123MP0002896_abnormal_bone_mineralization0.81187204
124MP0005187_abnormal_penis_morphology0.81183517
125MP0001765_abnormal_ion_homeostasis0.80752020
126MP0002932_abnormal_joint_morphology0.78959861
127MP0002697_abnormal_eye_size0.78495569
128MP0002822_catalepsy0.78090822
129MP0005220_abnormal_exocrine_pancreas0.77670090
130MP0006035_abnormal_mitochondrial_morpho0.77579874
131MP0008789_abnormal_olfactory_epithelium0.76951800
132MP0003786_premature_aging0.75914721
133MP0009703_decreased_birth_body0.75863794
134MP0001944_abnormal_pancreas_morphology0.75107220
135MP0002184_abnormal_innervation0.74426017
136MP0002752_abnormal_somatic_nervous0.74325474
137MP0003755_abnormal_palate_morphology0.74304945
138MP0005391_vision/eye_phenotype0.73839273
139MP0006138_congestive_heart_failure0.73716261
140MP0003633_abnormal_nervous_system0.73693871
141MP0000462_abnormal_digestive_system0.73595730
142MP0005389_reproductive_system_phenotype0.73201699
143MP0002109_abnormal_limb_morphology0.72947468
144MP0000163_abnormal_cartilage_morphology0.72673504
145MP0004085_abnormal_heartbeat0.72267763
146MP0002115_abnormal_skeleton_extremities0.72148797
147MP0002735_abnormal_chemical_nociception0.71658827
148MP0002114_abnormal_axial_skeleton0.71620136
149MP0005670_abnormal_white_adipose0.70095408
150MP0002127_abnormal_cardiovascular_syste0.69962939
151MP0003137_abnormal_impulse_conducting0.69295829
152MP0004811_abnormal_neuron_physiology0.68447903
153MP0005253_abnormal_eye_physiology0.68217271
154MP0003699_abnormal_female_reproductive0.68082690
155MP0003938_abnormal_ear_development0.67838337
156MP0003861_abnormal_nervous_system0.67118682
157MP0003122_maternal_imprinting0.66275678
158MP0000026_abnormal_inner_ear0.66067033
159MP0005647_abnormal_sex_gland0.65210281
160MP0003879_abnormal_hair_cell0.63142332
161MP0003787_abnormal_imprinting0.62433231
162MP0003690_abnormal_glial_cell0.61911087
163MP0005409_darkened_coat_color0.57559274
164MP0004043_abnormal_pH_regulation0.56970836
165MP0001501_abnormal_sleep_pattern0.56121988
166MP0003121_genomic_imprinting0.55609317
167MP0004036_abnormal_muscle_relaxation0.53741184
168MP0005195_abnormal_posterior_eye0.52790012
169MP0005645_abnormal_hypothalamus_physiol0.52020457
170MP0006036_abnormal_mitochondrial_physio0.51540586

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)8.47149750
2Abnormal respiratory motile cilium morphology (HP:0005938)8.09088461
3Abnormal respiratory epithelium morphology (HP:0012253)8.09088461
4Cerebellar dysplasia (HP:0007033)7.17392288
5Rhinitis (HP:0012384)7.06702520
6Type II lissencephaly (HP:0007260)6.92441724
7Abnormal ciliary motility (HP:0012262)6.92049319
8Infertility (HP:0000789)5.96874626
9Chronic bronchitis (HP:0004469)5.94884586
10Calf muscle hypertrophy (HP:0008981)5.02022074
11Shoulder girdle muscle weakness (HP:0003547)4.58060280
12Muscle hypertrophy of the lower extremities (HP:0008968)4.40104605
13Nasal polyposis (HP:0100582)4.29952350
14Pelvic girdle muscle weakness (HP:0003749)4.14761957
15Nephronophthisis (HP:0000090)4.07754287
16Abnormality of the hip-girdle musculature (HP:0001445)4.05556623
17Abnormality of the musculature of the pelvis (HP:0001469)4.05556623
18Hypoplasia of the pons (HP:0012110)4.01895303
19Male infertility (HP:0003251)3.96638802
2011 pairs of ribs (HP:0000878)3.79505417
21Bronchiectasis (HP:0002110)3.76181139
22Limb-girdle muscle atrophy (HP:0003797)3.73375379
23Abnormality of the pons (HP:0007361)3.66420943
24Myoglobinuria (HP:0002913)3.50566321
25True hermaphroditism (HP:0010459)3.41318150
26Abnormality of the nasal mucosa (HP:0000433)3.30702604
27Medial flaring of the eyebrow (HP:0010747)3.10632042
28Increased corneal curvature (HP:0100692)3.10205107
29Keratoconus (HP:0000563)3.10205107
30Aplasia/Hypoplasia of the fovea (HP:0008060)3.08870845
31Hypoplasia of the fovea (HP:0007750)3.08870845
32Bronchitis (HP:0012387)3.02822385
33Abnormality of the renal medulla (HP:0100957)2.99102206
34Neonatal short-limb short stature (HP:0008921)2.96461354
35Barrel-shaped chest (HP:0001552)2.95661206
36Frequent falls (HP:0002359)2.93111259
37Abnormality of midbrain morphology (HP:0002418)2.84640599
38Molar tooth sign on MRI (HP:0002419)2.84640599
39Concave nail (HP:0001598)2.76218758
40Neurofibrillary tangles (HP:0002185)2.74119742
41Oligodactyly (hands) (HP:0001180)2.70540175
42Abnormality of the fibula (HP:0002991)2.69719483
43Abnormal spermatogenesis (HP:0008669)2.63612265
44Abnormal sex determination (HP:0012244)2.62031302
45Sex reversal (HP:0012245)2.62031302
46Hypoplastic iliac wings (HP:0002866)2.60582138
47Hypoglycemic coma (HP:0001325)2.58494486
48Abnormal finger flexion creases (HP:0006143)2.52285273
49Congenital stationary night blindness (HP:0007642)2.49275463
50Fibular aplasia (HP:0002990)2.48829641
51Abnormality of the calf musculature (HP:0001430)2.47875189
52Lissencephaly (HP:0001339)2.45703301
53Severe muscular hypotonia (HP:0006829)2.44935891
54Tubulointerstitial nephritis (HP:0001970)2.42961835
55Gait imbalance (HP:0002141)2.41615748
56Left ventricular hypertrophy (HP:0001712)2.40830144
57Recurrent otitis media (HP:0000403)2.39613220
58Limb-girdle muscle weakness (HP:0003325)2.36306327
59Meningocele (HP:0002435)2.34718420
60Abnormality of the fovea (HP:0000493)2.32114806
61Hypothermia (HP:0002045)2.30805294
62Difficulty climbing stairs (HP:0003551)2.29469204
63Hypoventilation (HP:0002791)2.29100456
64Amyotrophic lateral sclerosis (HP:0007354)2.28406685
65Retinal dysplasia (HP:0007973)2.27138658
66Focal motor seizures (HP:0011153)2.26531737
67Fibular hypoplasia (HP:0003038)2.26363698
68Pancreatic cysts (HP:0001737)2.25694489
69Neuroendocrine neoplasm (HP:0100634)2.25202930
70Gonadotropin excess (HP:0000837)2.25188484
71Congenital primary aphakia (HP:0007707)2.22550929
72Recurrent sinusitis (HP:0011108)2.21690599
73Hypoplasia of the capital femoral epiphysis (HP:0003090)2.20720757
74Abnormal hair whorl (HP:0010721)2.20578802
75Abnormality of the lower motor neuron (HP:0002366)2.20488941
76Cholecystitis (HP:0001082)2.18492544
77Abnormal gallbladder physiology (HP:0012438)2.18492544
78Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.18270455
79Degeneration of the lateral corticospinal tracts (HP:0002314)2.18270455
80Polydipsia (HP:0001959)2.14751899
81Abnormal drinking behavior (HP:0030082)2.14751899
82Cerebral inclusion bodies (HP:0100314)2.14222982
83Hypoplastic pelvis (HP:0008839)2.14137933
843-Methylglutaconic aciduria (HP:0003535)2.13778725
85Myokymia (HP:0002411)2.10734432
86Abnormality of the vitreous humor (HP:0004327)2.04228359
87Spastic tetraparesis (HP:0001285)2.03830579
88Disproportionate short-trunk short stature (HP:0003521)2.03121505
89Azoospermia (HP:0000027)2.00941315
90Abnormality of the renal cortex (HP:0011035)2.00818679
91Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.2629191
92Dynein arm defect of respiratory motile cilia (HP:0012255)10.7366356
93Absent/shortened dynein arms (HP:0200106)10.7366356
94Nephrogenic diabetes insipidus (HP:0009806)1.98941493
95Tubular atrophy (HP:0000092)1.98271180
96Sensory axonal neuropathy (HP:0003390)1.98228045
97Scrotal hypoplasia (HP:0000046)1.96967880
98Tubulointerstitial abnormality (HP:0001969)1.95554311
99Aplasia/Hypoplasia of the macula (HP:0008059)1.95444140
100EMG: myopathic abnormalities (HP:0003458)1.93772218
101Aplasia/Hypoplasia of the fibula (HP:0006492)1.91352302
102Missing ribs (HP:0000921)1.91253736
103Aplasia/Hypoplasia of the lens (HP:0008063)1.90732080
104Gaze-evoked nystagmus (HP:0000640)1.87928659
105Abnormal rod and cone electroretinograms (HP:0008323)1.87256343
106Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.85796104
107Pheochromocytoma (HP:0002666)1.85402718
108Hemiparesis (HP:0001269)1.85258759
109Generalized aminoaciduria (HP:0002909)1.84034136
110Aplasia/hypoplasia of the uterus (HP:0008684)1.83535513
111Chronic hepatic failure (HP:0100626)1.83129982
112Male pseudohermaphroditism (HP:0000037)1.82882010
113Postaxial foot polydactyly (HP:0001830)1.81823854
114Genital tract atresia (HP:0001827)1.81018117
115Proximal tubulopathy (HP:0000114)1.80997469
116Progressive cerebellar ataxia (HP:0002073)1.80532728
117Postaxial hand polydactyly (HP:0001162)1.80093496
118Vaginal atresia (HP:0000148)1.79047311
119Polyphagia (HP:0002591)1.78535855
120Aplasia/Hypoplasia affecting the retina (HP:0008061)1.78396569
121Aplasia/Hypoplasia of the scapulae (HP:0006713)1.78090897
122Hypoplastic scapulae (HP:0000882)1.78090897
123Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.76661543
124Absent epiphyses (HP:0010577)1.76661543
125Choroideremia (HP:0001139)1.74885316
126Atonic seizures (HP:0010819)1.74728830
127Abnormality of the corticospinal tract (HP:0002492)1.74382827
128Intellectual disability, profound (HP:0002187)1.73132829
129Poor coordination (HP:0002370)1.72143619
130Oculomotor apraxia (HP:0000657)1.71764817
131Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.69962670
132Proximal amyotrophy (HP:0007126)1.69663341
133Muscular dystrophy (HP:0003560)1.69241220
134Hypoplastic ischia (HP:0003175)1.68731160
135Impulsivity (HP:0100710)1.68264756
136Hypoplastic ilia (HP:0000946)1.67304723
137Central scotoma (HP:0000603)1.65248208
138Abnormality of permanent molar morphology (HP:0011071)1.64614110
139Abnormality of the dental root (HP:0006486)1.64614110
140Taurodontia (HP:0000679)1.64614110
141Epileptic encephalopathy (HP:0200134)1.63485345
142Renal cortical cysts (HP:0000803)1.63352317
143Short femoral neck (HP:0100864)1.62695141
144Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.62527534
145Pancreatic fibrosis (HP:0100732)1.61249078
146Supernumerary spleens (HP:0009799)1.60560003
147Peripheral hypomyelination (HP:0007182)1.59885070
148Abnormality of dentin (HP:0010299)1.58225469
149Stage 5 chronic kidney disease (HP:0003774)1.56536143
150Abnormality of the dental pulp (HP:0006479)1.50778311
151Supranuclear gaze palsy (HP:0000605)1.49191962
152Progressive inability to walk (HP:0002505)1.47979968
153Hyperventilation (HP:0002883)1.47908799
154Abnormality of molar morphology (HP:0011070)1.47890437
155Abnormality of molar (HP:0011077)1.47890437
156Spastic gait (HP:0002064)1.47611281
157Congenital hepatic fibrosis (HP:0002612)1.47230748
158Delayed gross motor development (HP:0002194)1.45876256
159Abnormality of renal excretion (HP:0011036)1.45495140
160Termporal pattern (HP:0011008)1.45491891
161Insidious onset (HP:0003587)1.45491891
162Aplasia involving bones of the upper limbs (HP:0009823)1.44755979
163Aplasia of the phalanges of the hand (HP:0009802)1.44755979
164Aplasia involving bones of the extremities (HP:0009825)1.44755979
165Focal seizures (HP:0007359)1.42267786
166Tubulointerstitial fibrosis (HP:0005576)1.41526131
167Renal dysplasia (HP:0000110)1.41405674
168Short ribs (HP:0000773)1.40013086
169Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.39982866
170Optic disc pallor (HP:0000543)1.39880820
171Impaired vibratory sensation (HP:0002495)1.37847881
172Clonus (HP:0002169)1.37619876
173Abnormality of ocular smooth pursuit (HP:0000617)1.37124985

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.18238661
2PDK47.18238661
3PDK24.58725556
4PRKD34.39009898
5FRK3.66286845
6TESK13.31020909
7STK393.19480972
8PNCK2.91565169
9ICK2.84327095
10MAP3K22.36239565
11WNK42.27617978
12VRK12.23244091
13PTK2B1.94254375
14ADRBK21.93532164
15TSSK61.92949712
16MAP3K121.75899708
17EPHA41.75349026
18ERBB31.52561034
19MUSK1.49955908
20STK381.47700851
21MKNK11.41452599
22CASK1.41440652
23EPHA21.40682749
24MAP3K41.37383347
25PLK31.34177406
26TYRO31.30226594
27MAP4K21.29617120
28EIF2AK31.28326617
29OXSR11.25986117
30NTRK21.23761090
31MARK11.17905442
32TNIK1.17534079
33MAP2K71.14648468
34NEK21.13184218
35WNK11.13173544
36BRD41.12126745
37CSNK1G10.98707864
38GRK10.96337093
39INSRR0.95968747
40MAP3K90.95410358
41FER0.95283049
42MST40.94198823
43PASK0.93764676
44DDR20.93592190
45ROCK10.92960706
46MET0.91793652
47MAPKAPK50.91771439
48MAP3K60.89951064
49PDK10.89512115
50CDK190.88894112
51PAK60.87086632
52MAPKAPK30.86997795
53NTRK30.85333913
54CDK80.84716268
55MAPK130.84238801
56STK38L0.83678507
57TESK20.83552695
58ERBB40.83315757
59BRAF0.81022657
60CCNB10.79198848
61MST1R0.77575451
62LATS20.75971375
63MAP2K10.74845490
64STK30.73653223
65IRAK30.73488396
66AKT30.71274536
67MINK10.71271392
68PRKCE0.70055632
69PINK10.70018595
70PAK20.69547016
71BMPR1B0.69032273
72CSNK1A1L0.68937450
73DYRK30.68248835
74CDC70.67766424
75CAMK2A0.66342466
76BCR0.66219726
77ADRBK10.65560963
78TTK0.63788392
79GSK3A0.63206557
80CDK120.63063574
81CDK30.63038976
82LMTK20.61958108
83MAP2K40.60127086
84MAPK150.59877076
85CDK180.59646384
86CDK150.59225136
87UHMK10.58654259
88CDK140.58234349
89PDPK10.56733362
90BLK0.56627624
91ACVR1B0.54807809
92TGFBR10.52836292
93PLK10.52770056
94CDK50.52447800
95PRKCG0.51017119
96YES10.50530983
97PRKD10.49852850
98PLK40.49727431
99CDK11A0.48654444
100KSR20.47474170
101TAF10.46423276
102MARK20.45494965
103RIPK40.45111215
104DAPK30.43933061
105PTK20.43326787
106CDC42BPA0.43089707
107WEE10.42163512
108TRIM280.41735168
109CHEK20.41509021
110PHKG20.40240790
111PHKG10.40240790
112TAOK10.39471603
113DYRK1B0.38387558
114ARAF0.37282271
115SGK2230.36950897
116SGK4940.36950897
117IRAK20.36268433
118NTRK10.35774601
119STK160.35567294
120TLK10.34015055
121EIF2AK10.33793194
122PAK30.33166735
123CAMK2B0.32595744
124CSNK1G20.32581148
125DYRK20.32409000
126CHUK0.31845606
127PLK20.31826342
128MAP3K70.31709071
129DYRK1A0.31521792
130CHEK10.30606844
131TAOK30.29751780
132ABL10.29546878
133CDK90.29454429
134RAF10.29194896
135FGR0.28804887
136PKN10.28037691
137NEK60.27410079
138DAPK20.24912667
139WNK30.24482395
140MAP3K50.24383697
141LATS10.24137895
142TGFBR20.23987060
143MKNK20.23824911
144CAMK2D0.23043357
145CSNK1G30.22230678
146PRKD20.22146115
147BMPR20.20283423
148PRKACA0.19598633
149STK110.18325254
150CSNK1D0.18180819
151PAK10.18171652
152PRKG10.17286508
153KSR10.17250275
154PRKACB0.16461057
155ATM0.16168288

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049505.24499714
2Vitamin B6 metabolism_Homo sapiens_hsa007503.99884203
3Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.40239427
4Fatty acid biosynthesis_Homo sapiens_hsa000612.88296253
5Pyruvate metabolism_Homo sapiens_hsa006202.86592996
6Primary bile acid biosynthesis_Homo sapiens_hsa001202.67295758
7Protein export_Homo sapiens_hsa030602.63728249
8Nicotine addiction_Homo sapiens_hsa050332.47568521
9Regulation of autophagy_Homo sapiens_hsa041402.44842080
10Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.41180037
11Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.36124347
12Dorso-ventral axis formation_Homo sapiens_hsa043202.31776631
13Propanoate metabolism_Homo sapiens_hsa006402.27751850
14Linoleic acid metabolism_Homo sapiens_hsa005912.19547632
15Huntingtons disease_Homo sapiens_hsa050162.18944086
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.16623037
17Amphetamine addiction_Homo sapiens_hsa050312.15971899
18Ether lipid metabolism_Homo sapiens_hsa005652.15161243
19Cardiac muscle contraction_Homo sapiens_hsa042602.06521477
20Oxidative phosphorylation_Homo sapiens_hsa001902.01984859
21Oocyte meiosis_Homo sapiens_hsa041141.99606830
22Basal transcription factors_Homo sapiens_hsa030221.91113509
23Synaptic vesicle cycle_Homo sapiens_hsa047211.79500116
24Glutamatergic synapse_Homo sapiens_hsa047241.75144725
25Collecting duct acid secretion_Homo sapiens_hsa049661.73686286
26Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.72290389
27Long-term potentiation_Homo sapiens_hsa047201.71189376
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.69266189
29Glucagon signaling pathway_Homo sapiens_hsa049221.59831919
30Non-homologous end-joining_Homo sapiens_hsa034501.52272315
31Circadian entrainment_Homo sapiens_hsa047131.51080634
32Renin secretion_Homo sapiens_hsa049241.49354697
33Peroxisome_Homo sapiens_hsa041461.48680162
34Parkinsons disease_Homo sapiens_hsa050121.47555765
35Alzheimers disease_Homo sapiens_hsa050101.46829336
36Tryptophan metabolism_Homo sapiens_hsa003801.45476749
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.44538057
38Morphine addiction_Homo sapiens_hsa050321.44041126
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.40042128
40Glycerophospholipid metabolism_Homo sapiens_hsa005641.39959667
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.36973204
42Homologous recombination_Homo sapiens_hsa034401.36689329
43GABAergic synapse_Homo sapiens_hsa047271.34084650
44Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.33082018
45Salivary secretion_Homo sapiens_hsa049701.26764978
46Systemic lupus erythematosus_Homo sapiens_hsa053221.26381700
47Circadian rhythm_Homo sapiens_hsa047101.22966040
48Glycerolipid metabolism_Homo sapiens_hsa005611.22230334
49Calcium signaling pathway_Homo sapiens_hsa040201.18692438
50Insulin secretion_Homo sapiens_hsa049111.17319275
51Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.16260541
52Chemical carcinogenesis_Homo sapiens_hsa052041.13498611
53Dopaminergic synapse_Homo sapiens_hsa047281.12948291
54Taste transduction_Homo sapiens_hsa047421.11364374
55Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.10084753
56Cocaine addiction_Homo sapiens_hsa050301.09871428
57Gastric acid secretion_Homo sapiens_hsa049711.09315667
58Olfactory transduction_Homo sapiens_hsa047401.09094928
59Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.02000698
60Arginine and proline metabolism_Homo sapiens_hsa003301.01730622
61Mismatch repair_Homo sapiens_hsa034301.01195067
62ABC transporters_Homo sapiens_hsa020101.00969860
63Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.00633683
64Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.98394865
65Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.98077992
66Cysteine and methionine metabolism_Homo sapiens_hsa002700.96275787
67beta-Alanine metabolism_Homo sapiens_hsa004100.95683529
68Serotonergic synapse_Homo sapiens_hsa047260.94300168
69Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.94108767
70Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.92485039
71Fatty acid elongation_Homo sapiens_hsa000620.91787959
72Pentose phosphate pathway_Homo sapiens_hsa000300.91187418
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.91142985
74Asthma_Homo sapiens_hsa053100.90833150
75Carbohydrate digestion and absorption_Homo sapiens_hsa049730.89955716
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.89323402
77Estrogen signaling pathway_Homo sapiens_hsa049150.88194482
78Fatty acid metabolism_Homo sapiens_hsa012120.87013723
79p53 signaling pathway_Homo sapiens_hsa041150.86883800
80Ovarian steroidogenesis_Homo sapiens_hsa049130.84994274
81Long-term depression_Homo sapiens_hsa047300.82418866
82Fanconi anemia pathway_Homo sapiens_hsa034600.80593199
83Dilated cardiomyopathy_Homo sapiens_hsa054140.80274231
84cGMP-PKG signaling pathway_Homo sapiens_hsa040220.79072540
85Oxytocin signaling pathway_Homo sapiens_hsa049210.78959025
86cAMP signaling pathway_Homo sapiens_hsa040240.78476678
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.77738723
88Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.77200654
89PPAR signaling pathway_Homo sapiens_hsa033200.76868513
90Tight junction_Homo sapiens_hsa045300.76492729
91Mineral absorption_Homo sapiens_hsa049780.73757962
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.72099351
93Phototransduction_Homo sapiens_hsa047440.71637826
94Steroid biosynthesis_Homo sapiens_hsa001000.71013365
95Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.69376793
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.69339271
97Purine metabolism_Homo sapiens_hsa002300.69273116
98Legionellosis_Homo sapiens_hsa051340.69231189
99Aldosterone synthesis and secretion_Homo sapiens_hsa049250.69065996
100Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68390349
101Rheumatoid arthritis_Homo sapiens_hsa053230.65424226
102ECM-receptor interaction_Homo sapiens_hsa045120.65327112
103mRNA surveillance pathway_Homo sapiens_hsa030150.64362922
104Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.62761617
105Carbon metabolism_Homo sapiens_hsa012000.61637433
106Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.59903493
107Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.59264850
108Staphylococcus aureus infection_Homo sapiens_hsa051500.58758837
109Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58560684
110Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58367199
111Gap junction_Homo sapiens_hsa045400.57333333
112Nitrogen metabolism_Homo sapiens_hsa009100.56803093
113Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.56253838
114Fatty acid degradation_Homo sapiens_hsa000710.54724512
115Sulfur metabolism_Homo sapiens_hsa009200.53656459
116Phagosome_Homo sapiens_hsa041450.53535504
117Axon guidance_Homo sapiens_hsa043600.53529085
118Cholinergic synapse_Homo sapiens_hsa047250.53229503
119Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52916476
120Basal cell carcinoma_Homo sapiens_hsa052170.52763543
121Vibrio cholerae infection_Homo sapiens_hsa051100.52387147
122Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52003608
123Folate biosynthesis_Homo sapiens_hsa007900.51393510
124Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51143893
125Thyroid hormone synthesis_Homo sapiens_hsa049180.50360060
126TGF-beta signaling pathway_Homo sapiens_hsa043500.49395271
127Fructose and mannose metabolism_Homo sapiens_hsa000510.47814004
128Metabolic pathways_Homo sapiens_hsa011000.47650161
129Arachidonic acid metabolism_Homo sapiens_hsa005900.47394916
130Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47371608
131Glutathione metabolism_Homo sapiens_hsa004800.46548279
132Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.46289625
133Hedgehog signaling pathway_Homo sapiens_hsa043400.46171009
134N-Glycan biosynthesis_Homo sapiens_hsa005100.45477168
135Butanoate metabolism_Homo sapiens_hsa006500.45043834
136Alcoholism_Homo sapiens_hsa050340.44355203
137Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.44088339
138Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.43282236
139Sphingolipid metabolism_Homo sapiens_hsa006000.43215017
140Retinol metabolism_Homo sapiens_hsa008300.42389380
141Nucleotide excision repair_Homo sapiens_hsa034200.41774771
142Selenocompound metabolism_Homo sapiens_hsa004500.41404153
143Adherens junction_Homo sapiens_hsa045200.40895902
144GnRH signaling pathway_Homo sapiens_hsa049120.40849269
145Leishmaniasis_Homo sapiens_hsa051400.40392090
146Bile secretion_Homo sapiens_hsa049760.40359121
147Inositol phosphate metabolism_Homo sapiens_hsa005620.39358465
148Phospholipase D signaling pathway_Homo sapiens_hsa040720.39190261
149Complement and coagulation cascades_Homo sapiens_hsa046100.38572700
150Pancreatic secretion_Homo sapiens_hsa049720.38384829
151One carbon pool by folate_Homo sapiens_hsa006700.37330626
152Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.36081571

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