PFN1P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular response to ethanol (GO:0071361)5.19307821
2protein K11-linked deubiquitination (GO:0035871)5.08058563
3monoubiquitinated protein deubiquitination (GO:0035520)4.91307520
4establishment of protein localization to Golgi (GO:0072600)4.39331754
5regulation of hippo signaling (GO:0035330)4.35584895
6interkinetic nuclear migration (GO:0022027)4.32329368
7regulation of establishment of cell polarity (GO:2000114)4.21019112
8positive regulation of developmental pigmentation (GO:0048087)4.20452415
9protein K48-linked deubiquitination (GO:0071108)4.06358125
10cytoplasmic mRNA processing body assembly (GO:0033962)4.05614089
11regulation of pigment cell differentiation (GO:0050932)4.05505731
12neural tube formation (GO:0001841)4.00699291
13phospholipid translocation (GO:0045332)4.00564466
14lipid translocation (GO:0034204)4.00564466
15tryptophan catabolic process (GO:0006569)3.82164251
16indole-containing compound catabolic process (GO:0042436)3.82164251
17indolalkylamine catabolic process (GO:0046218)3.82164251
18regulation of translation, ncRNA-mediated (GO:0045974)3.81222575
19negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.81222575
20negative regulation of translation, ncRNA-mediated (GO:0040033)3.81222575
21regulation of establishment or maintenance of cell polarity (GO:0032878)3.58138085
22protein prenylation (GO:0018342)3.49734039
23prenylation (GO:0097354)3.49734039
24pericardium development (GO:0060039)3.47528256
25snRNA transcription (GO:0009301)3.47397996
26detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.47274972
27indolalkylamine metabolic process (GO:0006586)3.44081259
28protein K63-linked deubiquitination (GO:0070536)3.43541067
29negative regulation of complement activation (GO:0045916)3.40939371
30righting reflex (GO:0060013)3.40300752
31tryptophan metabolic process (GO:0006568)3.36392228
32negative regulation of protein activation cascade (GO:2000258)3.29496614
33establishment of protein localization to vacuole (GO:0072666)3.29000283
34protein targeting to vacuole (GO:0006623)3.29000283
35protein targeting to lysosome (GO:0006622)3.29000283
36phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.26123560
37oxidative demethylation (GO:0070989)3.20142080
38retrograde transport, vesicle recycling within Golgi (GO:0000301)3.19296005
39histone mRNA catabolic process (GO:0071044)3.15526546
40cellular response to sterol (GO:0036315)3.14737759
41protein targeting to Golgi (GO:0000042)3.13986356
42histone H3-K4 trimethylation (GO:0080182)3.13669609
43interleukin-6-mediated signaling pathway (GO:0070102)3.04455584
44sulfation (GO:0051923)3.03708553
45cAMP catabolic process (GO:0006198)3.03163247
46reflex (GO:0060004)2.98726006
47photoreceptor cell maintenance (GO:0045494)2.97530827
48cilium or flagellum-dependent cell motility (GO:0001539)2.96822564
49fibroblast migration (GO:0010761)2.90877929
50rRNA catabolic process (GO:0016075)2.89659644
51nucleus localization (GO:0051647)2.85989889
52cyclic nucleotide catabolic process (GO:0009214)2.85423622
53microtubule anchoring (GO:0034453)2.83054906
54kynurenine metabolic process (GO:0070189)2.82565208
55drug catabolic process (GO:0042737)2.80460064
56thyroid hormone metabolic process (GO:0042403)2.79925550
57negative regulation of systemic arterial blood pressure (GO:0003085)2.77354869
58flavonoid metabolic process (GO:0009812)2.73325146
59hepatocyte apoptotic process (GO:0097284)2.69405971
60regulation of MHC class I biosynthetic process (GO:0045343)2.66742671
61UDP-N-acetylglucosamine metabolic process (GO:0006047)2.61969577
62histone H3-K9 methylation (GO:0051567)2.61923603
63negative regulation of sodium ion transport (GO:0010766)2.61830880
64protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.61495802
65response to sterol (GO:0036314)2.56526608
66positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.55707563
67regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.55707563
68signal peptide processing (GO:0006465)2.52485477
69detection of light stimulus involved in visual perception (GO:0050908)2.52457639
70detection of light stimulus involved in sensory perception (GO:0050962)2.52457639
71peptidyl-lysine trimethylation (GO:0018023)2.51074134
72regulation of alkaline phosphatase activity (GO:0010692)2.51012399
73replicative senescence (GO:0090399)2.50240181
74amino-acid betaine transport (GO:0015838)2.50063402
75carnitine transport (GO:0015879)2.50063402
76regulation of protein polyubiquitination (GO:1902914)2.49998442
77adaptation of signaling pathway (GO:0023058)2.48498534
78peptidyl-lysine methylation (GO:0018022)2.45921454
79lymphangiogenesis (GO:0001946)2.45500901
80histone lysine methylation (GO:0034968)2.45342905
81sphingoid metabolic process (GO:0046519)2.44127381
82regulation of gene silencing by miRNA (GO:0060964)2.43578081
83regulation of gene silencing by RNA (GO:0060966)2.43578081
84regulation of posttranscriptional gene silencing (GO:0060147)2.43578081
85regulation of B cell receptor signaling pathway (GO:0050855)2.43235640
86Golgi to endosome transport (GO:0006895)2.42410707
87striated muscle atrophy (GO:0014891)2.40999635
88iron ion import (GO:0097286)2.40674929
89alkaloid metabolic process (GO:0009820)2.39253594
90carnitine transmembrane transport (GO:1902603)2.38877275
91histone H3-K9 modification (GO:0061647)2.38407789
92purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.37576009
933-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.37576009
94negative regulation of humoral immune response (GO:0002921)2.36505093
95positive regulation of mRNA catabolic process (GO:0061014)2.36422523
96interferon-gamma production (GO:0032609)2.35837186
97auditory receptor cell stereocilium organization (GO:0060088)2.32912174
98regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.31380159
99positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.31380159
100activated T cell proliferation (GO:0050798)2.30316217

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.58748040
2CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.13011292
3SMAD_19615063_ChIP-ChIP_OVARY_Human2.83413425
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.78014555
5POU3F2_20337985_ChIP-ChIP_501MEL_Human2.62906214
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.40700398
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.36498171
8SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.36272775
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.34823760
10TAF15_26573619_Chip-Seq_HEK293_Human2.30816737
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.30373910
12AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.29007266
13TP53_16413492_ChIP-PET_HCT116_Human2.19544987
14VDR_22108803_ChIP-Seq_LS180_Human2.05961276
15IGF1R_20145208_ChIP-Seq_DFB_Human2.03311282
16AR_21572438_ChIP-Seq_LNCaP_Human1.97944125
17ER_23166858_ChIP-Seq_MCF-7_Human1.97372739
18STAT3_23295773_ChIP-Seq_U87_Human1.96542923
19ZNF274_21170338_ChIP-Seq_K562_Hela1.94719769
20FLI1_27457419_Chip-Seq_LIVER_Mouse1.94657066
21PIAS1_25552417_ChIP-Seq_VCAP_Human1.92976695
22SALL1_21062744_ChIP-ChIP_HESCs_Human1.92148617
23SMAD4_21799915_ChIP-Seq_A2780_Human1.86198259
24EWS_26573619_Chip-Seq_HEK293_Human1.82949790
25CDX2_19796622_ChIP-Seq_MESCs_Mouse1.82557806
26STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.80724768
27PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.75523398
28P300_19829295_ChIP-Seq_ESCs_Human1.75173348
29FUS_26573619_Chip-Seq_HEK293_Human1.73704351
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.73207621
31ZNF217_24962896_ChIP-Seq_MCF-7_Human1.71142366
32ESR1_20079471_ChIP-ChIP_T-47D_Human1.70565128
33TCF4_23295773_ChIP-Seq_U87_Human1.68440904
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.67933991
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.64113656
36AHR_22903824_ChIP-Seq_MCF-7_Human1.58250417
37IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.57926491
38CBP_20019798_ChIP-Seq_JUKART_Human1.57926491
39NR3C1_21868756_ChIP-Seq_MCF10A_Human1.57437351
40EZH2_27294783_Chip-Seq_NPCs_Mouse1.54823314
41UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.53186944
42FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.51776927
43MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.51737810
44SUZ12_27294783_Chip-Seq_NPCs_Mouse1.50051717
45CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.47480104
46TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.44442050
47RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40956656
48SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40396670
49ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.39989204
50SMAD3_21741376_ChIP-Seq_EPCs_Human1.39761941
51ARNT_22903824_ChIP-Seq_MCF-7_Human1.39609024
52AR_25329375_ChIP-Seq_VCAP_Human1.39015371
53CTBP1_25329375_ChIP-Seq_LNCAP_Human1.38530164
54NFE2_27457419_Chip-Seq_LIVER_Mouse1.38349529
55TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37868409
56POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.37868409
57BCAT_22108803_ChIP-Seq_LS180_Human1.36120658
58SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35384438
59BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.34172744
60PCGF2_27294783_Chip-Seq_NPCs_Mouse1.33619150
61FOXM1_26456572_ChIP-Seq_MCF-7_Human1.29870266
62PRDM14_20953172_ChIP-Seq_ESCs_Human1.27695500
63FLI1_21867929_ChIP-Seq_TH2_Mouse1.27556967
64TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.26713186
65OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26499185
66IRF8_22096565_ChIP-ChIP_GC-B_Human1.25963986
67EGR1_23403033_ChIP-Seq_LIVER_Mouse1.25387581
68RXR_22108803_ChIP-Seq_LS180_Human1.24736073
69CJUN_26792858_Chip-Seq_BT549_Human1.22464087
70OCT4_21477851_ChIP-Seq_ESCs_Mouse1.22162645
71IRF1_19129219_ChIP-ChIP_H3396_Human1.21257910
72TCF4_22108803_ChIP-Seq_LS180_Human1.20327996
73ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.20323777
74CDX2_22108803_ChIP-Seq_LS180_Human1.19706628
75FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.19566531
76NRF2_20460467_ChIP-Seq_MEFs_Mouse1.19403903
77NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.19403903
78CRX_20693478_ChIP-Seq_RETINA_Mouse1.19075371
79CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.18085526
80NANOG_18555785_Chip-Seq_ESCs_Mouse1.17791797
81HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.17601748
82RUNX2_22187159_ChIP-Seq_PCA_Human1.16589139
83CTNNB1_20460455_ChIP-Seq_HCT116_Human1.15931489
84TP53_18474530_ChIP-ChIP_U2OS_Human1.14890978
85TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10925662
86ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.09849133
87E2F1_18555785_Chip-Seq_ESCs_Mouse1.09142516
88GATA2_21666600_ChIP-Seq_HMVEC_Human1.09082279
89TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.08696030
90SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.08219072
91KDM2B_26808549_Chip-Seq_REH_Human1.05271295
92IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.05053358
93NOTCH1_21737748_ChIP-Seq_TLL_Human1.04594307
94EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04549312
95RUNX_20019798_ChIP-Seq_JUKART_Human1.04544648
96P53_22387025_ChIP-Seq_ESCs_Mouse1.03035529
97SOX2_21211035_ChIP-Seq_LN229_Gbm1.01409478
98SMAD4_21741376_ChIP-Seq_EPCs_Human1.01104858
99BRD4_25478319_ChIP-Seq_HGPS_Human1.00042207
100TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99353997

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation6.26888489
2MP0008057_abnormal_DNA_replication6.06243804
3MP0002138_abnormal_hepatobiliary_system4.46123380
4MP0003195_calcinosis4.09084807
5MP0003252_abnormal_bile_duct3.42463862
6MP0003045_fibrosis2.54577690
7MP0000383_abnormal_hair_follicle2.37252407
8MP0002009_preneoplasia2.36815150
9MP0004043_abnormal_pH_regulation2.35579841
10MP0002928_abnormal_bile_duct2.32619204
11MP0005171_absent_coat_pigmentation2.24764252
12MP0000427_abnormal_hair_cycle2.22504250
13MP0005174_abnormal_tail_pigmentation2.21159726
14MP0002168_other_aberrant_phenotype2.15688170
15MP0003950_abnormal_plasma_membrane2.00174914
16MP0002736_abnormal_nociception_after1.82444979
17MP0006054_spinal_hemorrhage1.81902519
18MP0008961_abnormal_basal_metabolism1.79784638
19MP0000371_diluted_coat_color1.77383675
20MP0010678_abnormal_skin_adnexa1.74110049
21MP0001968_abnormal_touch/_nociception1.66031753
22MP0010386_abnormal_urinary_bladder1.61756707
23MP0003890_abnormal_embryonic-extraembry1.59372867
24MP0004381_abnormal_hair_follicle1.55026598
25MP0003763_abnormal_thymus_physiology1.53893747
26MP0005310_abnormal_salivary_gland1.52661959
27MP0001501_abnormal_sleep_pattern1.48918702
28MP0005085_abnormal_gallbladder_physiolo1.46326623
29MP0000015_abnormal_ear_pigmentation1.37417905
30MP0005551_abnormal_eye_electrophysiolog1.33099175
31MP0003300_gastrointestinal_ulcer1.32060999
32MP0003646_muscle_fatigue1.31960862
33MP0001986_abnormal_taste_sensitivity1.31861425
34MP0004130_abnormal_muscle_cell1.31558436
35MP0005167_abnormal_blood-brain_barrier1.25684673
36MP0003136_yellow_coat_color1.25059095
37MP0004142_abnormal_muscle_tone1.22886648
38MP0009697_abnormal_copulation1.20197220
39MP0005266_abnormal_metabolism1.16924922
40MP0003283_abnormal_digestive_organ1.15957143
41MP0005076_abnormal_cell_differentiation1.14941777
42MP0005395_other_phenotype1.13414592
43MP0002102_abnormal_ear_morphology1.11323744
44MP0000013_abnormal_adipose_tissue1.09200372
45MP0005647_abnormal_sex_gland1.07809671
46MP0003943_abnormal_hepatobiliary_system1.07156071
47MP0002876_abnormal_thyroid_physiology1.03970513
48MP0005670_abnormal_white_adipose1.02851465
49MP0004145_abnormal_muscle_electrophysio0.96040002
50MP0009046_muscle_twitch0.95810613
51MP0005253_abnormal_eye_physiology0.94330645
52MP0002166_altered_tumor_susceptibility0.92930364
53MP0005075_abnormal_melanosome_morpholog0.89911877
54MP0003183_abnormal_peptide_metabolism0.89571112
55MP0008877_abnormal_DNA_methylation0.88656466
56MP0000538_abnormal_urinary_bladder0.87731466
57MP0010329_abnormal_lipoprotein_level0.82648860
58MP0002075_abnormal_coat/hair_pigmentati0.81687685
59MP0002332_abnormal_exercise_endurance0.81413329
60MP0002006_tumorigenesis0.81231471
61MP0005164_abnormal_response_to0.80868668
62MP0005376_homeostasis/metabolism_phenot0.80480819
63MP0004883_abnormal_blood_vessel0.79881093
64MP0005386_behavior/neurological_phenoty0.79788144
65MP0004924_abnormal_behavior0.79788144
66MP0005360_urolithiasis0.78499665
67MP0003632_abnormal_nervous_system0.76950392
68MP0005220_abnormal_exocrine_pancreas0.74191787
69MP0009115_abnormal_fat_cell0.70642742
70MP0001984_abnormal_olfaction0.69829074
71MP0004264_abnormal_extraembryonic_tissu0.69627216
72MP0004134_abnormal_chest_morphology0.69443648
73MP0001879_abnormal_lymphatic_vessel0.68702100
74MP0005365_abnormal_bile_salt0.65685787
75MP0001324_abnormal_eye_pigmentation0.65561536
76MP0001486_abnormal_startle_reflex0.65522740
77MP0003868_abnormal_feces_composition0.65295462
78MP0000372_irregular_coat_pigmentation0.64962975
79MP0003724_increased_susceptibility_to0.63149310
80MP0002127_abnormal_cardiovascular_syste0.62843651
81MP0001270_distended_abdomen0.62793081
82MP0001800_abnormal_humoral_immune0.62124946
83MP0000249_abnormal_blood_vessel0.60618674
84MP0004084_abnormal_cardiac_muscle0.59787271
85MP0000230_abnormal_systemic_arterial0.59703318
86MP0002396_abnormal_hematopoietic_system0.59679032
87MP0000470_abnormal_stomach_morphology0.59163794
88MP0004484_altered_response_of0.58406962
89MP0009764_decreased_sensitivity_to0.56573034
90MP0002108_abnormal_muscle_morphology0.56504020
91MP0002751_abnormal_autonomic_nervous0.56095377
92MP0002067_abnormal_sensory_capabilities0.55521367
93MP0001919_abnormal_reproductive_system0.53860399
94MP0001661_extended_life_span0.52953172
95MP0010352_gastrointestinal_tract_polyps0.52160736
96MP0008875_abnormal_xenobiotic_pharmacok0.52073233
97MP0008872_abnormal_physiological_respon0.50854581
98MP0003631_nervous_system_phenotype0.50434886
99MP0003633_abnormal_nervous_system0.49946805
100MP0003091_abnormal_cell_migration0.49694432

Predicted human phenotypes

RankGene SetZ-score
1Hyperventilation (HP:0002883)4.89988020
2Genetic anticipation (HP:0003743)4.63514262
3Fair hair (HP:0002286)3.94606430
4Clumsiness (HP:0002312)3.84121563
5Gaze-evoked nystagmus (HP:0000640)3.73838611
6Protruding tongue (HP:0010808)3.67685198
7Hypoplastic labia majora (HP:0000059)3.67269658
8Abnormality of the renal cortex (HP:0011035)3.61486621
9Chronic hepatic failure (HP:0100626)3.55878551
10Abnormality of the labia majora (HP:0012881)3.43887099
11Pancreatic cysts (HP:0001737)3.39666403
12Generalized hypopigmentation of hair (HP:0011358)3.38101661
13Congenital sensorineural hearing impairment (HP:0008527)3.28028220
14Aplasia/Hypoplasia of the tibia (HP:0005772)3.19277908
15Widely spaced teeth (HP:0000687)2.93153555
16Absent speech (HP:0001344)2.92239465
17Progressive cerebellar ataxia (HP:0002073)2.83367757
18Enlarged kidneys (HP:0000105)2.74454554
19Renal cortical cysts (HP:0000803)2.72088946
20Stomach cancer (HP:0012126)2.70359396
21Abnormality of the nasal septum (HP:0000419)2.69169525
22Abnormality of the renal medulla (HP:0100957)2.63442256
23Short chin (HP:0000331)2.60859504
24Attenuation of retinal blood vessels (HP:0007843)2.52739234
25Febrile seizures (HP:0002373)2.36432890
26Pancreatic fibrosis (HP:0100732)2.35860913
27Blue irides (HP:0000635)2.29230261
28Decreased circulating renin level (HP:0003351)2.21207526
29Facial diplegia (HP:0001349)2.19592881
30Cupped ear (HP:0000378)2.18307587
31Arthropathy (HP:0003040)2.14536762
32Truncal obesity (HP:0001956)2.13467481
33Cerebellar dysplasia (HP:0007033)2.12915363
34Nephronophthisis (HP:0000090)2.12640555
35Abnormal pancreas size (HP:0012094)2.12028397
36Small hand (HP:0200055)2.09301444
37Prominent nose (HP:0000448)2.08768656
38True hermaphroditism (HP:0010459)2.04986606
39Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.04838018
40Thyroiditis (HP:0100646)2.02157716
41Labial hypoplasia (HP:0000066)2.01288795
42Lower limb hyperreflexia (HP:0002395)2.00155495
43Cystic liver disease (HP:0006706)2.00138782
44Acute myeloid leukemia (HP:0004808)1.98231228
45Molar tooth sign on MRI (HP:0002419)1.93265785
46Abnormality of midbrain morphology (HP:0002418)1.93265785
47Abnormality of the ischium (HP:0003174)1.92892317
48Subacute progressive viral hepatitis (HP:0006572)1.91944372
49Hyperkalemia (HP:0002153)1.89131193
50Sandal gap (HP:0001852)1.89119646
51Short foot (HP:0001773)1.87298129
52Narrow palate (HP:0000189)1.84551028
53Tented upper lip vermilion (HP:0010804)1.84163158
54Abnormality of chloride homeostasis (HP:0011422)1.83897998
55Congenital hepatic fibrosis (HP:0002612)1.83566654
56Dysmetric saccades (HP:0000641)1.83493379
57Volvulus (HP:0002580)1.77878176
58Highly arched eyebrow (HP:0002553)1.77070883
59Tubulointerstitial nephritis (HP:0001970)1.77027965
60T lymphocytopenia (HP:0005403)1.75994165
61Absent radius (HP:0003974)1.74480998
62Increased density of long bones (HP:0006392)1.73372832
63Bulbous nose (HP:0000414)1.70699181
64Preaxial foot polydactyly (HP:0001841)1.70209993
65Hypoplastic ischia (HP:0003175)1.70121915
66Abnormality of T cell number (HP:0011839)1.69123574
67Abnormality of secondary sexual hair (HP:0009888)1.68808421
68Abnormality of the axillary hair (HP:0100134)1.68808421
69Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.67486538
70Increased corneal curvature (HP:0100692)1.66804537
71Keratoconus (HP:0000563)1.66804537
72Increased number of teeth (HP:0011069)1.66251295
73Acanthocytosis (HP:0001927)1.66227967
74Clubbing of toes (HP:0100760)1.64910557
75Progressive inability to walk (HP:0002505)1.63632407
76Medial flaring of the eyebrow (HP:0010747)1.63513922
77Abnormality of chromosome stability (HP:0003220)1.62795293
78Portal hypertension (HP:0001409)1.61730878
79Hematochezia (HP:0002573)1.61537475
80Hepatoblastoma (HP:0002884)1.61327208
81Poikiloderma (HP:0001029)1.61280242
82Aplasia involving forearm bones (HP:0009822)1.61148166
83Absent forearm bone (HP:0003953)1.61148166
84Abnormal glucose tolerance (HP:0001952)1.60796846
85Tubulointerstitial abnormality (HP:0001969)1.60763015
86Prostate neoplasm (HP:0100787)1.58489872
87Hypoplastic nipples (HP:0002557)1.57979629
88Type II lissencephaly (HP:0007260)1.57820326
89Macroglossia (HP:0000158)1.57657775
90Neonatal hypoglycemia (HP:0001998)1.56875092
91Abnormality of the right ventricle (HP:0001707)1.56337970
92Hypoplastic female external genitalia (HP:0012815)1.55593510
93Abnormality of the pubic bones (HP:0003172)1.55175108
94Tapered finger (HP:0001182)1.54918975
95Abnormality of incisor morphology (HP:0011063)1.54748542
96Poor coordination (HP:0002370)1.54313939
97Rectal prolapse (HP:0002035)1.54102548
98Bony spicule pigmentary retinopathy (HP:0007737)1.53944842
99Hypopigmentation of the fundus (HP:0007894)1.53291844
100Wide intermamillary distance (HP:0006610)1.52790907

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK8.24560235
2ACVR1B3.73349817
3BMPR1B3.20192908
4AKT33.17095606
5LATS12.43753758
6TAOK32.28331625
7NUAK12.09257250
8LMTK21.79033692
9CDK121.76260458
10TXK1.74457758
11TLK11.71635481
12STK38L1.63603161
13PIK3CA1.63294646
14BRD41.59164742
15FGFR21.54688893
16ZAK1.50275080
17MELK1.47507191
18BLK1.40601729
19ADRBK21.39261714
20MAP3K41.35768712
21PIK3CG1.34389876
22TRPM71.31558892
23TEC1.27255636
24SGK21.25442332
25MKNK21.23114142
26MAPK131.17682577
27TGFBR11.14474284
28NLK1.10798694
29PDGFRB1.06967404
30PDGFRA0.99911565
31CAMK1D0.97327560
32JAK10.94382553
33FER0.93898850
34WNK30.93156398
35CAMK1G0.89469804
36MAPK110.89308755
37BRSK20.87071496
38WNK10.86484295
39ADRBK10.84992301
40PINK10.82455485
41STK30.82103043
42CAMKK20.80434039
43INSRR0.79120198
44MAP3K140.77638092
45DMPK0.77228229
46GRK10.77188856
47EIF2AK30.75546411
48PTK2B0.72317660
49PRKAA20.72198648
50CHUK0.71228875
51RPS6KB20.71222727
52MAP3K70.70891679
53STK390.69233063
54PAK30.68003375
55MAPK70.67521314
56STK380.66427859
57MAP3K20.66061371
58SGK30.64437735
59FGFR30.63370618
60SGK4940.60005919
61SGK2230.60005919
62MARK30.59687799
63IKBKB0.59116182
64ITK0.55189325
65IKBKE0.55142370
66BTK0.54727090
67PRKAA10.53338383
68NEK20.51689872
69PRKCE0.51438143
70OBSCN0.50121827
71EEF2K0.46522761
72BCR0.46420370
73CAMK40.46170335
74KIT0.45548548
75IRAK10.45326704
76ERBB30.44822191
77CDK80.44347954
78TNK20.43498590
79PRKCQ0.42849594
80YES10.41721228
81NTRK30.40712313
82MAP2K10.40633540
83FLT30.39815143
84MAP2K70.38815013
85GRK70.37891849
86OXSR10.37424099
87MET0.37259274
88CSNK1A1L0.36605018
89EIF2AK20.35646728
90TNIK0.35335981
91CSNK1D0.35255496
92MAPKAPK30.34499820
93CASK0.33795500
94SYK0.33344126
95MTOR0.33152921
96MAPK10.32935268
97MKNK10.32281119
98CDK30.31568945
99PDK20.30778210
100WNK40.30004086

Predicted pathways (KEGG)

RankGene SetZ-score
1ABC transporters_Homo sapiens_hsa020102.83656544
2Dorso-ventral axis formation_Homo sapiens_hsa043201.91646907
3Lysine degradation_Homo sapiens_hsa003101.91292567
4Steroid hormone biosynthesis_Homo sapiens_hsa001401.87918215
5Primary bile acid biosynthesis_Homo sapiens_hsa001201.71135888
6Circadian rhythm_Homo sapiens_hsa047101.68794087
7Linoleic acid metabolism_Homo sapiens_hsa005911.63416178
8Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.63001535
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.45563839
10Butanoate metabolism_Homo sapiens_hsa006501.43813956
11Taste transduction_Homo sapiens_hsa047421.43302804
12Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.39382282
13Complement and coagulation cascades_Homo sapiens_hsa046101.37751504
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.35593878
15Nitrogen metabolism_Homo sapiens_hsa009101.30718435
16Selenocompound metabolism_Homo sapiens_hsa004501.27963060
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.25911738
18Tryptophan metabolism_Homo sapiens_hsa003801.23765622
19Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.23741104
20Phototransduction_Homo sapiens_hsa047441.21268533
21Nicotine addiction_Homo sapiens_hsa050331.21000537
22Vascular smooth muscle contraction_Homo sapiens_hsa042701.18464359
23Fanconi anemia pathway_Homo sapiens_hsa034601.17252110
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.16352632
25Retinol metabolism_Homo sapiens_hsa008301.10364326
26Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.09049092
27Histidine metabolism_Homo sapiens_hsa003401.06736750
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.05609141
29Chemical carcinogenesis_Homo sapiens_hsa052041.05325947
30Staphylococcus aureus infection_Homo sapiens_hsa051501.04273978
31Intestinal immune network for IgA production_Homo sapiens_hsa046721.03461877
32FoxO signaling pathway_Homo sapiens_hsa040681.01970804
33Ether lipid metabolism_Homo sapiens_hsa005651.01275621
34Platelet activation_Homo sapiens_hsa046111.01053087
35Homologous recombination_Homo sapiens_hsa034400.99911378
36Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.99484485
37Morphine addiction_Homo sapiens_hsa050320.95287053
38Calcium signaling pathway_Homo sapiens_hsa040200.94281282
39RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.92040239
40NF-kappa B signaling pathway_Homo sapiens_hsa040640.91330105
41Jak-STAT signaling pathway_Homo sapiens_hsa046300.89425385
42TGF-beta signaling pathway_Homo sapiens_hsa043500.88554992
43Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84340910
44Type II diabetes mellitus_Homo sapiens_hsa049300.83829287
45Sphingolipid metabolism_Homo sapiens_hsa006000.83782645
46Serotonergic synapse_Homo sapiens_hsa047260.81543090
47Maturity onset diabetes of the young_Homo sapiens_hsa049500.76241726
48MicroRNAs in cancer_Homo sapiens_hsa052060.74373493
49mTOR signaling pathway_Homo sapiens_hsa041500.74329319
50Insulin resistance_Homo sapiens_hsa049310.74184755
51Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.73945711
52Oxytocin signaling pathway_Homo sapiens_hsa049210.73247033
53Renin secretion_Homo sapiens_hsa049240.73040052
54Glycerolipid metabolism_Homo sapiens_hsa005610.72995727
55Small cell lung cancer_Homo sapiens_hsa052220.72007552
56Caffeine metabolism_Homo sapiens_hsa002320.71950753
57Olfactory transduction_Homo sapiens_hsa047400.71023117
58Circadian entrainment_Homo sapiens_hsa047130.68744509
59Ovarian steroidogenesis_Homo sapiens_hsa049130.68327462
60cAMP signaling pathway_Homo sapiens_hsa040240.68270323
61Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.68212874
62Bile secretion_Homo sapiens_hsa049760.67000162
63Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65003940
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64390269
65Salivary secretion_Homo sapiens_hsa049700.62979584
66Arachidonic acid metabolism_Homo sapiens_hsa005900.62490143
67Prostate cancer_Homo sapiens_hsa052150.61998661
68Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.61823754
69ECM-receptor interaction_Homo sapiens_hsa045120.61732055
70NOD-like receptor signaling pathway_Homo sapiens_hsa046210.61557214
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.61439392
72Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.60215630
73TNF signaling pathway_Homo sapiens_hsa046680.58930354
74Prolactin signaling pathway_Homo sapiens_hsa049170.58652970
75Graft-versus-host disease_Homo sapiens_hsa053320.58279332
76beta-Alanine metabolism_Homo sapiens_hsa004100.58127319
77Choline metabolism in cancer_Homo sapiens_hsa052310.57934120
78Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.57829007
79Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.56347858
80T cell receptor signaling pathway_Homo sapiens_hsa046600.55574728
81Glutamatergic synapse_Homo sapiens_hsa047240.55295650
82Systemic lupus erythematosus_Homo sapiens_hsa053220.55288644
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.54751560
84Cholinergic synapse_Homo sapiens_hsa047250.54386371
85Fatty acid biosynthesis_Homo sapiens_hsa000610.54018115
86cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52759063
87Melanoma_Homo sapiens_hsa052180.51384198
88Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50781074
89Non-small cell lung cancer_Homo sapiens_hsa052230.50239302
90Focal adhesion_Homo sapiens_hsa045100.50082423
91Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.49546352
92Vitamin digestion and absorption_Homo sapiens_hsa049770.48853801
93Gastric acid secretion_Homo sapiens_hsa049710.48319141
94Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47771122
95Basal transcription factors_Homo sapiens_hsa030220.47476508
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46356139
97Asthma_Homo sapiens_hsa053100.46326060
98Glioma_Homo sapiens_hsa052140.45965226
99Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.45769859
100Toxoplasmosis_Homo sapiens_hsa051450.45702673

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