PFKL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the liver (L) subunit of an enzyme that catalyzes the conversion of D-fructose 6-phosphate to D-fructose 1,6-bisphosphate, which is a key step in glucose metabolism (glycolysis). This enzyme is a tetramer that may be composed of different subunits encoded by distinct genes in different tissues. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.26912860
2regulation of translational fidelity (GO:0006450)4.71214817
3regulation of gene silencing by RNA (GO:0060966)4.65681289
4regulation of posttranscriptional gene silencing (GO:0060147)4.65681289
5regulation of gene silencing by miRNA (GO:0060964)4.65681289
6pentose-phosphate shunt (GO:0006098)4.47212137
7pre-miRNA processing (GO:0031054)4.46110518
8folic acid-containing compound biosynthetic process (GO:0009396)4.43203758
9IMP biosynthetic process (GO:0006188)4.38008516
10peptidyl-arginine omega-N-methylation (GO:0035247)4.31453780
11negative regulation of erythrocyte differentiation (GO:0045647)4.25274216
12mannose metabolic process (GO:0006013)4.21135415
13paraxial mesoderm development (GO:0048339)4.14228668
14* glycolytic process (GO:0006096)4.05341256
15regulation of translational termination (GO:0006449)3.89299833
16retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.82689613
17protein localization to kinetochore (GO:0034501)3.82119263
18heterochromatin organization (GO:0070828)3.81551024
19NADPH regeneration (GO:0006740)3.78402909
20IMP metabolic process (GO:0046040)3.74192232
21proline biosynthetic process (GO:0006561)3.74069147
22nuclear pore organization (GO:0006999)3.65560388
23peptidyl-arginine methylation (GO:0018216)3.64485051
24peptidyl-arginine N-methylation (GO:0035246)3.64485051
25peptidyl-lysine dimethylation (GO:0018027)3.63485348
26histone arginine methylation (GO:0034969)3.53586199
27negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.48353728
28protein retention in ER lumen (GO:0006621)3.47704922
29establishment of apical/basal cell polarity (GO:0035089)3.45439694
30barbed-end actin filament capping (GO:0051016)3.45135969
31mitotic nuclear envelope disassembly (GO:0007077)3.42064474
32maternal placenta development (GO:0001893)3.40882427
33positive regulation of Cdc42 GTPase activity (GO:0043089)3.40560851
34positive regulation of SMAD protein import into nucleus (GO:0060391)3.40490018
35nucleobase biosynthetic process (GO:0046112)3.34212606
36nuclear pore complex assembly (GO:0051292)3.33611132
37protein localization to endosome (GO:0036010)3.32541007
38spliceosomal tri-snRNP complex assembly (GO:0000244)3.32367244
39protein hydroxylation (GO:0018126)3.32107486
40peptidyl-proline hydroxylation (GO:0019511)3.31915819
41nodal signaling pathway (GO:0038092)3.30247122
42apoptotic process involved in morphogenesis (GO:0060561)3.29872323
43tricarboxylic acid cycle (GO:0006099)3.29314204
44glucose 6-phosphate metabolic process (GO:0051156)3.28415298
45nuclear envelope disassembly (GO:0051081)3.25188521
46membrane disassembly (GO:0030397)3.25188521
47pinocytosis (GO:0006907)3.22757570
48DNA duplex unwinding (GO:0032508)3.20710433
49maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.19269616
50negative regulation of histone methylation (GO:0031061)3.18929888
51DNA geometric change (GO:0032392)3.17550197
52mitotic G1 DNA damage checkpoint (GO:0031571)3.17424131
53regulation of extracellular matrix disassembly (GO:0010715)3.16735335
54formation of translation preinitiation complex (GO:0001731)3.15589733
55regulation of cholesterol homeostasis (GO:2000188)3.14985375
56regulation of hippo signaling (GO:0035330)3.13151776
57DNA replication-dependent nucleosome assembly (GO:0006335)3.10529262
58DNA replication-dependent nucleosome organization (GO:0034723)3.10529262
59negative regulation of cell size (GO:0045792)3.09253417
604-hydroxyproline metabolic process (GO:0019471)3.08473959
61dosage compensation (GO:0007549)3.07637363
62DNA replication initiation (GO:0006270)3.05018459
63polarized epithelial cell differentiation (GO:0030859)3.03674376
64DNA strand elongation involved in DNA replication (GO:0006271)3.02974313
65epithelial cell differentiation involved in prostate gland development (GO:0060742)3.02637518
66semaphorin-plexin signaling pathway (GO:0071526)3.01573550
67regulation of glucose import in response to insulin stimulus (GO:2001273)2.99226950
68* pyruvate metabolic process (GO:0006090)2.95361192
69regulation of SMAD protein import into nucleus (GO:0060390)2.95317877
70activation of Rac GTPase activity (GO:0032863)2.93756052
71glucose catabolic process (GO:0006007)2.93713969
72establishment or maintenance of monopolar cell polarity (GO:0061339)2.91509756
73establishment of monopolar cell polarity (GO:0061162)2.91509756
74regulation of mammary gland epithelial cell proliferation (GO:0033599)2.91274830
75negative regulation of RNA splicing (GO:0033119)2.90620207
76positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.86985843
77DNA strand elongation (GO:0022616)2.86731881
78regulation of cofactor metabolic process (GO:0051193)2.86635779
79regulation of coenzyme metabolic process (GO:0051196)2.86635779
80proline metabolic process (GO:0006560)2.83989571
81galactose catabolic process (GO:0019388)2.82430573
82cytoskeletal anchoring at plasma membrane (GO:0007016)2.82238585
83positive regulation of transcription regulatory region DNA binding (GO:2000679)2.81061795
84modulation by symbiont of host cellular process (GO:0044068)2.80568941
85NIK/NF-kappaB signaling (GO:0038061)2.79099194
86translational elongation (GO:0006414)2.76447342
87viral transcription (GO:0019083)2.76336791
88sister chromatid segregation (GO:0000819)2.74613220
89apoptotic process involved in development (GO:1902742)2.73830577
90regulation of early endosome to late endosome transport (GO:2000641)2.73669757
91antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.73215425
92mitotic sister chromatid segregation (GO:0000070)2.73213218
93antigen processing and presentation of endogenous antigen (GO:0019883)2.72799398
94protein localization to chromosome, centromeric region (GO:0071459)2.72579834
95response to laminar fluid shear stress (GO:0034616)2.71910356
96gluconeogenesis (GO:0006094)2.71259693
97endothelial cell chemotaxis (GO:0035767)2.70690692
98activation of MAPKKK activity (GO:0000185)2.70563961
99thymic T cell selection (GO:0045061)2.70056189
100basement membrane organization (GO:0071711)2.70033761
101regulation of histone H3-K9 methylation (GO:0051570)2.69996916
102antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.69080862
103ribosomal small subunit assembly (GO:0000028)2.68511236
104chaperone-mediated protein complex assembly (GO:0051131)2.67909268
105translational termination (GO:0006415)2.66258045
106negative regulation of mRNA processing (GO:0050686)2.65386921
107glucocorticoid receptor signaling pathway (GO:0042921)2.64756787
108NADH metabolic process (GO:0006734)2.63966923
109urea cycle (GO:0000050)2.63606626
110adherens junction assembly (GO:0034333)2.63533947
111positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.62961578
112protein kinase C signaling (GO:0070528)2.62810830
113embryonic process involved in female pregnancy (GO:0060136)2.61988819
114GDP-mannose metabolic process (GO:0019673)2.61607540
115purine nucleobase biosynthetic process (GO:0009113)2.61386557
116amyloid precursor protein catabolic process (GO:0042987)2.61157701
117mRNA stabilization (GO:0048255)2.58726439
118RNA stabilization (GO:0043489)2.58726439
119establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.57631499
120negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.57569361
121epithelial cell-cell adhesion (GO:0090136)2.56903635
122chromatin assembly (GO:0031497)2.56801505
123negative regulation of fatty acid transport (GO:2000192)2.56151499
124modulation by virus of host process (GO:0019054)2.56122914
125positive regulation of synapse maturation (GO:0090129)2.55274058
126adhesion of symbiont to host (GO:0044406)2.54990679
127embryonic foregut morphogenesis (GO:0048617)2.54858528
128nuclear envelope organization (GO:0006998)2.54736703
129positive regulation of RNA splicing (GO:0033120)2.54654574
130regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.54530892
131regulation of cholesterol biosynthetic process (GO:0045540)2.54191263
132stress fiber assembly (GO:0043149)2.53928677
133negative regulation of viral release from host cell (GO:1902187)2.52980334
134cell-substrate adherens junction assembly (GO:0007045)2.52812794
135focal adhesion assembly (GO:0048041)2.52812794
136cardiac myofibril assembly (GO:0055003)2.52539413
137regulation of type I interferon-mediated signaling pathway (GO:0060338)2.52145444
138tricarboxylic acid metabolic process (GO:0072350)2.52128319
139cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.51844746
140negative regulation of mRNA metabolic process (GO:1903312)2.51805149
141regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.50974417
142activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.50907501
143activation of JUN kinase activity (GO:0007257)2.50534545
144tRNA aminoacylation for protein translation (GO:0006418)2.50177117
145response to muramyl dipeptide (GO:0032495)2.49619410
146translational initiation (GO:0006413)2.46718616
147mitotic G1/S transition checkpoint (GO:0044819)2.46403667
148intracellular estrogen receptor signaling pathway (GO:0030520)2.45831637
149nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.45483247
150positive thymic T cell selection (GO:0045059)2.45189857
151regulation of gene silencing (GO:0060968)2.44972462
152COPI coating of Golgi vesicle (GO:0048205)2.44899680
153Golgi transport vesicle coating (GO:0048200)2.44899680
154cell communication by electrical coupling (GO:0010644)2.44867989
155peptidyl-tyrosine autophosphorylation (GO:0038083)2.44381392
156positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.42002699
157planar cell polarity pathway involved in neural tube closure (GO:0090179)2.40638177
158positive regulation of fatty acid biosynthetic process (GO:0045723)2.40158540
159positive regulation of nuclease activity (GO:0032075)2.39844679
160positive regulation of histone deacetylation (GO:0031065)2.38491370
161regulation of cholesterol metabolic process (GO:0090181)2.38253314
162regulation of cholesterol storage (GO:0010885)2.37655428
163regulation of defense response to virus by virus (GO:0050690)2.37260813
164urea metabolic process (GO:0019627)2.36930109
165glutamine family amino acid biosynthetic process (GO:0009084)2.36034960
166regulation of necrotic cell death (GO:0010939)2.35670562
167cell-cell junction maintenance (GO:0045217)2.32573622
168UV protection (GO:0009650)2.31898396
1693-UTR-mediated mRNA stabilization (GO:0070935)2.31718969
170modulation by virus of host morphology or physiology (GO:0019048)2.31137955
171endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.29258838
172vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.28883756
173cellular response to virus (GO:0098586)2.28813636
174peptide catabolic process (GO:0043171)2.26373235
175regulation of extracellular matrix organization (GO:1903053)2.26148991
176negative regulation of myotube differentiation (GO:0010832)2.25833670
177nitrogen cycle metabolic process (GO:0071941)2.25625502
178vascular endothelial growth factor signaling pathway (GO:0038084)2.22522894
179positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.22492498
180cell-substrate junction assembly (GO:0007044)2.22437862
181positive regulation of blood vessel endothelial cell migration (GO:0043536)2.21933039
182branching involved in mammary gland duct morphogenesis (GO:0060444)2.20858210
183positive regulation by symbiont of host defense response (GO:0052509)2.19720164
184modulation by symbiont of host defense response (GO:0052031)2.19720164
185modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.19720164
186positive regulation by organism of defense response of other organism involved in symbiotic interact2.19720164
187modulation by symbiont of host immune response (GO:0052553)2.19720164

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.34313739
2* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.96106687
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.39332523
4* MYC_18555785_ChIP-Seq_MESCs_Mouse3.25600011
5EGR1_19374776_ChIP-ChIP_THP-1_Human2.84651496
6MYC_22102868_ChIP-Seq_BL_Human2.74651771
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.74635902
8THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.71996258
9POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.49987998
10ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.47067111
11* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.38826098
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.38281091
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.17650816
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.04856790
15TP63_17297297_ChIP-ChIP_HaCaT_Human2.04412073
16ESR1_15608294_ChIP-ChIP_MCF-7_Human2.03412735
17ZFP281_18757296_ChIP-ChIP_E14_Mouse1.99809429
18* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.99631044
19* HIF1A_21447827_ChIP-Seq_MCF-7_Human1.99199837
20* XRN2_22483619_ChIP-Seq_HELA_Human1.97449018
21SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.96999515
22TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.93130322
23VDR_21846776_ChIP-Seq_THP-1_Human1.80529992
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.80445559
25* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.76908841
26STAT3_1855785_ChIP-Seq_MESCs_Mouse1.75795188
27* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.75677562
28ZNF263_19887448_ChIP-Seq_K562_Human1.73029474
29ESR2_21235772_ChIP-Seq_MCF-7_Human1.70284215
30NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.66691020
31NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.66609887
32HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.66227853
33KDM2B_26808549_Chip-Seq_K562_Human1.65179746
34VDR_24763502_ChIP-Seq_THP-1_Human1.64741132
35ELK3_25401928_ChIP-Seq_HUVEC_Human1.60804987
36SRY_22984422_ChIP-ChIP_TESTIS_Rat1.59947176
37TET1_21451524_ChIP-Seq_MESCs_Mouse1.59646055
38KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.55739627
39ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.55453130
40CIITA_25753668_ChIP-Seq_RAJI_Human1.53375574
41NANOG_18555785_ChIP-Seq_MESCs_Mouse1.52449808
42* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.51215146
43E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.51134588
44SA1_27219007_Chip-Seq_ERYTHROID_Human1.50956764
45TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.50746498
46CLOCK_20551151_ChIP-Seq_293T_Human1.49741086
47CTCF_27219007_Chip-Seq_ERYTHROID_Human1.49442180
48MAF_26560356_Chip-Seq_TH1_Human1.48534363
49KDM2B_26808549_Chip-Seq_DND41_Human1.48354637
50LXR_22292898_ChIP-Seq_THP-1_Human1.48267470
51* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.47919763
52SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.47545111
53ERG_21242973_ChIP-ChIP_JURKAT_Human1.47178370
54RARG_19884340_ChIP-ChIP_MEFs_Mouse1.45243147
55SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.44507604
56* SMC4_20622854_ChIP-Seq_HELA_Human1.43912920
57DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.39725337
58DNAJC2_21179169_ChIP-ChIP_NT2_Human1.39261507
59TCF3_18692474_ChIP-Seq_MEFs_Mouse1.37898948
60ATF3_27146783_Chip-Seq_COLON_Human1.36970859
61* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.36146024
62E2F1_21310950_ChIP-Seq_MCF-7_Human1.36056081
63CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.35838331
64KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.34100779
65ETS1_20019798_ChIP-Seq_JURKAT_Human1.33291981
66ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.33251556
67THAP11_20581084_ChIP-Seq_MESCs_Mouse1.33136659
68EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32811751
69UTX_26944678_Chip-Seq_JUKART_Human1.32299750
70ZFP281_27345836_Chip-Seq_ESCs_Mouse1.31588452
71AR_21909140_ChIP-Seq_LNCAP_Human1.31368267
72KLF4_18555785_ChIP-Seq_MESCs_Mouse1.31319680
73MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.29625382
74* RACK7_27058665_Chip-Seq_MCF-7_Human1.29431633
75* MAF_26560356_Chip-Seq_TH2_Human1.28987180
76KDM2B_26808549_Chip-Seq_JURKAT_Human1.28607259
77* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.28309249
78CREB1_26743006_Chip-Seq_LNCaP_Human1.27879827
79TCF7_22412390_ChIP-Seq_EML_Mouse1.27872065
80RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.26835176
81* BCOR_27268052_Chip-Seq_Bcells_Human1.26781534
82NANOG_21062744_ChIP-ChIP_HESCs_Human1.26749619
83KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.26732678
84KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.26732678
85KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.26732678
86RUNX1_22412390_ChIP-Seq_EML_Mouse1.26429148
87CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.24558518
88* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.24407762
89* BCL6_27268052_Chip-Seq_Bcells_Human1.24153467
90POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.24106318
91MYCN_18555785_ChIP-Seq_MESCs_Mouse1.23277547
92TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.23191184
93KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.22182259
94KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.21941298
95TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.21685613
96TP53_22127205_ChIP-Seq_IMR90_Human1.21636515
97KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.21252812
98SOX2_18555785_ChIP-Seq_MESCs_Mouse1.20951665
99PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20696337
100* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.20695368
101* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.19371371
102TTF2_22483619_ChIP-Seq_HELA_Human1.19358671
103TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.19337573
104* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.18645113
105BRD4_27068464_Chip-Seq_AML-cells_Mouse1.18545329
106VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.18373796
107TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17458411
108P300_27058665_Chip-Seq_ZR-75-30cells_Human1.17444135
109MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.16823892
110SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.15914181
111CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.15430275
112RUNX1_27514584_Chip-Seq_MCF-7_Human1.14737279
113STAT6_21828071_ChIP-Seq_BEAS2B_Human1.14485944
114MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.14259846
115PPARA_22158963_ChIP-Seq_LIVER_Mouse1.13795413
116SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.13438577
117KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.13375864
118P68_20966046_ChIP-Seq_HELA_Human1.13077417
119CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.12976485
120ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.11804502
121* GATA1_19941827_ChIP-Seq_MEL_Mouse1.10496256
122KDM5A_27292631_Chip-Seq_BREAST_Human1.09829435
123RXR_22158963_ChIP-Seq_LIVER_Mouse1.09576453
124* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.09251905
125ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.08632427
126BP1_19119308_ChIP-ChIP_Hs578T_Human1.08166658
127NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.07728133
128TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.07197261
129GABP_19822575_ChIP-Seq_HepG2_Human1.07193996
130UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.07145523
131TFEB_21752829_ChIP-Seq_HELA_Human1.06171468
132STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.04841624
133MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.04728326
134RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.04200207
135* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03918755
136CTCF_27219007_Chip-Seq_Bcells_Human1.03661103
137CTCF_26484167_Chip-Seq_Bcells_Mouse1.02547798
138EST1_17652178_ChIP-ChIP_JURKAT_Human1.02232519
139SOX2_18692474_ChIP-Seq_MEFs_Mouse1.01240658
140DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.00629522
141GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00409102
142MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.00229189
143KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.00137871
144NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.00036070
145ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.99650369
146* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.98906216
147SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.97900100
148SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.97657409
149POU5F1_16518401_ChIP-PET_MESCs_Mouse0.97306814
150POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.97095137
151DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.96967510
152NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.96142667
153RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.95822323
154NCOR1_26117541_ChIP-Seq_K562_Human0.95402353
155ELF1_20517297_ChIP-Seq_JURKAT_Human0.94005203
156NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.93751565
157SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.93646234

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology3.93015234
2MP0003705_abnormal_hypodermis_morpholog3.49778492
3MP0005451_abnormal_body_composition3.21595998
4MP0009840_abnormal_foam_cell3.20773985
5MP0003123_paternal_imprinting3.02303748
6MP0004084_abnormal_cardiac_muscle2.83065584
7MP0010352_gastrointestinal_tract_polyps2.80136818
8MP0010234_abnormal_vibrissa_follicle2.72452559
9MP0008260_abnormal_autophagy2.67827911
10MP0002653_abnormal_ependyma_morphology2.65953192
11MP0003283_abnormal_digestive_organ2.63767125
12MP0004233_abnormal_muscle_weight2.60112449
13MP0003191_abnormal_cellular_cholesterol2.48242736
14MP0003303_peritoneal_inflammation2.41641714
15MP0003436_decreased_susceptibility_to2.35257899
16MP0003172_abnormal_lysosome_physiology2.28560747
17MP0003111_abnormal_nucleus_morphology2.22008464
18MP0005076_abnormal_cell_differentiation2.18993622
19MP0004957_abnormal_blastocyst_morpholog2.16041075
20MP0010030_abnormal_orbit_morphology2.13236130
21MP0001730_embryonic_growth_arrest2.06646083
22MP0003077_abnormal_cell_cycle2.04120273
23MP0003567_abnormal_fetal_cardiomyocyte2.02132528
24MP0003566_abnormal_cell_adhesion1.99026193
25MP0003300_gastrointestinal_ulcer1.97194506
26MP0003329_amyloid_beta_deposits1.96177370
27MP0000537_abnormal_urethra_morphology1.90987039
28MP0003183_abnormal_peptide_metabolism1.85392149
29MP0010094_abnormal_chromosome_stability1.82836749
30MP0005360_urolithiasis1.78523805
31MP0001849_ear_inflammation1.75085747
32MP0005380_embryogenesis_phenotype1.71742488
33MP0001672_abnormal_embryogenesis/_devel1.71742488
34MP0005670_abnormal_white_adipose1.70251629
35MP0003984_embryonic_growth_retardation1.69450803
36MP0002088_abnormal_embryonic_growth/wei1.68698216
37MP0010307_abnormal_tumor_latency1.68050036
38MP0005257_abnormal_intraocular_pressure1.67915772
39MP0003693_abnormal_embryo_hatching1.67726702
40MP0002084_abnormal_developmental_patter1.66768070
41MP0004197_abnormal_fetal_growth/weight/1.64850090
42MP0004947_skin_inflammation1.63804034
43MP0001697_abnormal_embryo_size1.63783900
44MP0000350_abnormal_cell_proliferation1.62468727
45MP0003453_abnormal_keratinocyte_physiol1.60795515
46MP0010630_abnormal_cardiac_muscle1.60167799
47MP0003091_abnormal_cell_migration1.57276459
48MP0004264_abnormal_extraembryonic_tissu1.55915202
49MP0005666_abnormal_adipose_tissue1.55625898
50MP0003119_abnormal_digestive_system1.55618733
51MP0005623_abnormal_meninges_morphology1.52526792
52MP0002085_abnormal_embryonic_tissue1.51820314
53MP0004858_abnormal_nervous_system1.51261366
54MP0001958_emphysema1.51026840
55MP0002080_prenatal_lethality1.50905731
56MP0008007_abnormal_cellular_replicative1.50383460
57MP0000858_altered_metastatic_potential1.50209664
58MP0000750_abnormal_muscle_regeneration1.49895402
59MP0002796_impaired_skin_barrier1.46885662
60MP0000685_abnormal_immune_system1.46873427
61MP0002086_abnormal_extraembryonic_tissu1.45680801
62MP0003646_muscle_fatigue1.45206199
63MP0004272_abnormal_basement_membrane1.44869018
64MP0008775_abnormal_heart_ventricle1.44806302
65MP0003279_aneurysm1.44735559
66MP0003122_maternal_imprinting1.44348956
67MP0003121_genomic_imprinting1.43876654
68MP0000604_amyloidosis1.42347041
69MP0004185_abnormal_adipocyte_glucose1.40589902
70MP0005409_darkened_coat_color1.39002577
71MP0006138_congestive_heart_failure1.37048629
72MP0002837_dystrophic_cardiac_calcinosis1.36465947
73MP0004133_heterotaxia1.35870296
74MP0010155_abnormal_intestine_physiology1.35440197
75MP0009333_abnormal_splenocyte_physiolog1.31023779
76MP0002234_abnormal_pharynx_morphology1.30348758
77MP0005025_abnormal_response_to1.29568128
78MP0005464_abnormal_platelet_physiology1.28344211
79MP0005330_cardiomyopathy1.27999250
80MP0000751_myopathy1.27392535
81MP0000490_abnormal_crypts_of1.27148056
82MP0008438_abnormal_cutaneous_collagen1.26811074
83MP0001873_stomach_inflammation1.26363777
84MP0003878_abnormal_ear_physiology1.25554165
85MP0005377_hearing/vestibular/ear_phenot1.25554165
86MP0004087_abnormal_muscle_fiber1.25137412
87MP0002877_abnormal_melanocyte_morpholog1.24029562
88MP0002269_muscular_atrophy1.23657952
89MP0008932_abnormal_embryonic_tissue1.22131755
90MP0003763_abnormal_thymus_physiology1.20211313
91MP0005501_abnormal_skin_physiology1.18523563
92MP0005385_cardiovascular_system_phenoty1.18383990
93MP0001544_abnormal_cardiovascular_syste1.18383990
94MP0009053_abnormal_anal_canal1.18269537
95MP0009672_abnormal_birth_weight1.17416090
96MP0001545_abnormal_hematopoietic_system1.17253440
97MP0005397_hematopoietic_system_phenotyp1.17253440
98MP0001348_abnormal_lacrimal_gland1.17227865
99MP0005375_adipose_tissue_phenotype1.15921177
100MP0003115_abnormal_respiratory_system1.15678621
101MP0003221_abnormal_cardiomyocyte_apopto1.15389592
102MP0004215_abnormal_myocardial_fiber1.15138784
103MP0005023_abnormal_wound_healing1.14088601
104MP0005000_abnormal_immune_tolerance1.13464550
105MP0002419_abnormal_innate_immunity1.12502663
106MP0004130_abnormal_muscle_cell1.11360316
107MP0003075_altered_response_to1.11154979
108MP0001293_anophthalmia1.10764381
109MP0006072_abnormal_retinal_apoptosis1.10123474
110MP0001835_abnormal_antigen_presentation1.10102830
111MP0001790_abnormal_immune_system1.07511157
112MP0005387_immune_system_phenotype1.07511157
113MP0003866_abnormal_defecation1.07421525
114MP0000534_abnormal_ureter_morphology1.07063353
115MP0008770_decreased_survivor_rate1.06809689
116MP0000465_gastrointestinal_hemorrhage1.05713130
117MP0002998_abnormal_bone_remodeling1.04819046
118MP0001533_abnormal_skeleton_physiology1.04741450
119MP0000371_diluted_coat_color1.03476596
120MP0000266_abnormal_heart_morphology1.03206001
121MP0004036_abnormal_muscle_relaxation1.02792739
122MP0002925_abnormal_cardiovascular_devel1.01917025
123MP0002060_abnormal_skin_morphology1.01126976
124MP0002249_abnormal_larynx_morphology1.00472846
125MP0000733_abnormal_muscle_development0.95788919
126MP0009384_cardiac_valve_regurgitation0.95644202
127MP0003890_abnormal_embryonic-extraembry0.95227049
128MP0008961_abnormal_basal_metabolism0.94499387
129MP0002139_abnormal_hepatobiliary_system0.92249692
130MP0004510_myositis0.92066584
131MP0000767_abnormal_smooth_muscle0.91425013
132MP0003942_abnormal_urinary_system0.91408879
133MP0002127_abnormal_cardiovascular_syste0.90689463
134MP0002909_abnormal_adrenal_gland0.90344196
135MP0000003_abnormal_adipose_tissue0.89175537
136MP0004782_abnormal_surfactant_physiolog0.89169986
137MP0001915_intracranial_hemorrhage0.88951020
138MP0000358_abnormal_cell_content/0.88444261
139MP0002452_abnormal_antigen_presenting0.88380663
140MP0002972_abnormal_cardiac_muscle0.88063070
141MP0005621_abnormal_cell_physiology0.87950577
142MP0009931_abnormal_skin_appearance0.87671233
143MP0001819_abnormal_immune_cell0.87564970
144MP0002420_abnormal_adaptive_immunity0.87210947
145MP0002089_abnormal_postnatal_growth/wei0.86844870
146MP0002697_abnormal_eye_size0.86266422
147MP0001800_abnormal_humoral_immune0.84585664
148MP0000759_abnormal_skeletal_muscle0.84146319
149MP0004381_abnormal_hair_follicle0.83032641
150MP0002396_abnormal_hematopoietic_system0.82892137
151MP0002111_abnormal_tail_morphology0.82807082
152MP0000313_abnormal_cell_death0.82399178
153MP0002723_abnormal_immune_serum0.81595406
154MP0002098_abnormal_vibrissa_morphology0.81461332
155MP0002166_altered_tumor_susceptibility0.81221062
156MP0000681_abnormal_thyroid_gland0.80978707
157MP0003634_abnormal_glial_cell0.80495461
158MP0000477_abnormal_intestine_morphology0.80274669
159MP0008874_decreased_physiological_sensi0.80189581
160MP0009278_abnormal_bone_marrow0.80107134
161MP0002398_abnormal_bone_marrow0.79953914
162MP0000716_abnormal_immune_system0.79171882
163MP0003828_pulmonary_edema0.77451512
164MP0002429_abnormal_blood_cell0.77364229
165MP0001216_abnormal_epidermal_layer0.77178107
166MP0000678_abnormal_parathyroid_gland0.76553214
167MP0000372_irregular_coat_pigmentation0.76470543
168MP0006054_spinal_hemorrhage0.76373185
169MP0000428_abnormal_craniofacial_morphol0.75858578
170MP0009703_decreased_birth_body0.74434884
171MP0002896_abnormal_bone_mineralization0.70211508
172MP0001845_abnormal_inflammatory_respons0.69507277
173MP0000747_muscle_weakness0.68850192
174MP0002933_joint_inflammation0.68412212
175MP0005166_decreased_susceptibility_to0.68232109
176MP0005390_skeleton_phenotype0.68006297
177MP0003690_abnormal_glial_cell0.66267015
178MP0002722_abnormal_immune_system0.65790751

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)4.64123008
2Myoglobinuria (HP:0002913)3.56294031
3Exercise-induced muscle cramps (HP:0003710)3.55368926
4Abnormality of the astrocytes (HP:0100707)3.45126554
5Astrocytoma (HP:0009592)3.45126554
6Hyperacusis (HP:0010780)3.37061262
7Cerebral aneurysm (HP:0004944)3.13365465
8Abnormality of the lower motor neuron (HP:0002366)3.10677125
9Rhabdomyolysis (HP:0003201)3.05149277
10Premature rupture of membranes (HP:0001788)2.97844937
11Angiofibromas (HP:0010615)2.96582645
12Adenoma sebaceum (HP:0009720)2.96582645
13J-shaped sella turcica (HP:0002680)2.89430158
14Renal duplication (HP:0000075)2.89192092
15Hand muscle atrophy (HP:0009130)2.88865344
16Selective tooth agenesis (HP:0001592)2.88520696
17Vertebral compression fractures (HP:0002953)2.78591207
18Cholecystitis (HP:0001082)2.75498040
19Abnormal gallbladder physiology (HP:0012438)2.75498040
20Thin bony cortex (HP:0002753)2.73405487
21Hemorrhage of the eye (HP:0011885)2.70563270
22Upper limb amyotrophy (HP:0009129)2.67496501
23Distal upper limb amyotrophy (HP:0007149)2.67496501
24Dysostosis multiplex (HP:0000943)2.62543076
25Protrusio acetabuli (HP:0003179)2.59003487
26Annular pancreas (HP:0001734)2.54535028
27Distal lower limb amyotrophy (HP:0008944)2.54074271
28Cellulitis (HP:0100658)2.53983131
29Shallow orbits (HP:0000586)2.53722498
30Broad face (HP:0000283)2.51278966
31Flat acetabular roof (HP:0003180)2.45522675
32Colon cancer (HP:0003003)2.44932872
33Insomnia (HP:0100785)2.43430442
34Cervical subluxation (HP:0003308)2.41879127
35Eczematoid dermatitis (HP:0000976)2.41620245
36Biconcave vertebral bodies (HP:0004586)2.38829233
37Deviation of the thumb (HP:0009603)2.37626345
38Centrally nucleated skeletal muscle fibers (HP:0003687)2.35707482
39Bowel diverticulosis (HP:0005222)2.35607485
40Colitis (HP:0002583)2.34518440
41Proximal placement of thumb (HP:0009623)2.31650905
42Glioma (HP:0009733)2.30448251
43Sudden death (HP:0001699)2.30401695
44Pointed chin (HP:0000307)2.29530499
45Systemic lupus erythematosus (HP:0002725)2.28022657
46Elfin facies (HP:0004428)2.27505377
47Posterior subcapsular cataract (HP:0007787)2.27445793
48Increased cerebral lipofuscin (HP:0011813)2.25571885
49Broad palm (HP:0001169)2.23714023
50Deep venous thrombosis (HP:0002625)2.23339735
51Abnormality of the Achilles tendon (HP:0005109)2.19765934
52Enlarged penis (HP:0000040)2.19651317
53Increased nuchal translucency (HP:0010880)2.18505501
54Abnormality of glycolipid metabolism (HP:0010969)2.17996769
55Abnormality of liposaccharide metabolism (HP:0010968)2.17996769
56Abnormality of glycosphingolipid metabolism (HP:0004343)2.17996769
57Distal lower limb muscle weakness (HP:0009053)2.15552071
58Disproportionate tall stature (HP:0001519)2.14861995
59Missing ribs (HP:0000921)2.13908539
60Polygenic inheritance (HP:0010982)2.13201406
61Hypopigmentation of the fundus (HP:0007894)2.13149262
62Stridor (HP:0010307)2.12632757
63Lymphangioma (HP:0100764)2.10852530
64Dysmetric saccades (HP:0000641)2.10093178
65Fibroma (HP:0010614)2.09563721
66Aneurysm (HP:0002617)2.09025197
67Multiple enchondromatosis (HP:0005701)2.08702257
68Mucopolysacchariduria (HP:0008155)2.08032664
69Urinary glycosaminoglycan excretion (HP:0003541)2.08032664
70Emphysema (HP:0002097)2.07083181
71Intestinal polyp (HP:0005266)2.04807732
72Neuronal loss in central nervous system (HP:0002529)2.03494374
73Abnormality of mucopolysaccharide metabolism (HP:0011020)2.02226074
74Abnormality of polysaccharide metabolism (HP:0011012)2.02226074
75Abnormality of glycosaminoglycan metabolism (HP:0004371)2.02226074
76Ankle contracture (HP:0006466)2.01633757
77Spastic diplegia (HP:0001264)2.00450612
78Ulnar bowing (HP:0003031)1.99379018
79Ventricular tachycardia (HP:0004756)1.99267184
80Scotoma (HP:0000575)1.98678699
81Ragged-red muscle fibers (HP:0003200)1.98613752
82Abnormality of the thoracic spine (HP:0100711)1.98141593
83Reticulocytosis (HP:0001923)1.97729742
84Obstructive sleep apnea (HP:0002870)1.97310862
85Long palpebral fissure (HP:0000637)1.97285473
86Medulloblastoma (HP:0002885)1.97083303
87Cerebral inclusion bodies (HP:0100314)1.96275446
88Intestinal polyposis (HP:0200008)1.95973304
89Abnormality of glycolysis (HP:0004366)1.95586012
90Increased serum pyruvate (HP:0003542)1.95586012
91Fibrous tissue neoplasm (HP:0012316)1.95293464
92Neurofibrillary tangles (HP:0002185)1.94724343
93Pendular nystagmus (HP:0012043)1.94700697
94Central scotoma (HP:0000603)1.94384815
95Limb-girdle muscle atrophy (HP:0003797)1.93885923
96Increased connective tissue (HP:0009025)1.93599555
97Gastrointestinal dysmotility (HP:0002579)1.92939054
98Pseudobulbar signs (HP:0002200)1.92881738
99Bladder diverticulum (HP:0000015)1.92874874
100Loss of speech (HP:0002371)1.91759634
101Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.90955426
102Increased neuronal autofluorescent lipopigment (HP:0002074)1.90212658
103Segmental peripheral demyelination/remyelination (HP:0003481)1.89637369
104Gastrointestinal stroma tumor (HP:0100723)1.89618765
105Difficulty climbing stairs (HP:0003551)1.88832580
106Right ventricular cardiomyopathy (HP:0011663)1.88786137
107Renovascular hypertension (HP:0100817)1.88662897
108Increased IgE level (HP:0003212)1.88560713
109Neoplasm of the oral cavity (HP:0100649)1.87690206
110Congenital stationary night blindness (HP:0007642)1.87278382
111Asymmetry of the thorax (HP:0001555)1.86826026
112Flattened epiphyses (HP:0003071)1.86393601
113Axonal loss (HP:0003447)1.85083523
114Freckling (HP:0001480)1.84828105
115Resting tremor (HP:0002322)1.84691515
116Overriding aorta (HP:0002623)1.84010288
117Malnutrition (HP:0004395)1.83689737
118Gastrointestinal inflammation (HP:0004386)1.83059186
119Growth hormone excess (HP:0000845)1.82887534
120Cutaneous melanoma (HP:0012056)1.82513006
121Thoracic kyphosis (HP:0002942)1.82386558
122Mitral regurgitation (HP:0001653)1.82369220
123Abnormality of abdominal situs (HP:0011620)1.82145015
124Abdominal situs inversus (HP:0003363)1.82145015
125Short humerus (HP:0005792)1.81190200
126Blue sclerae (HP:0000592)1.80013594
127Vertebral hypoplasia (HP:0008417)1.79890628
128Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.79890628
129Increased variability in muscle fiber diameter (HP:0003557)1.79318034
130Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.79264025
131Short 4th metacarpal (HP:0010044)1.79264025
132Nuclear cataract (HP:0100018)1.79203729
133Premature skin wrinkling (HP:0100678)1.79118883
134Abdominal distention (HP:0003270)1.78379810
135Hypertriglyceridemia (HP:0002155)1.78029054
136Achilles tendon contracture (HP:0001771)1.77842060
137Megalocornea (HP:0000485)1.77352313
138Esophageal atresia (HP:0002032)1.76993352
139Hypercortisolism (HP:0001578)1.76570152
140Abnormality of macrophages (HP:0004311)1.76443972
141Abnormality of complement system (HP:0005339)1.76421232
142Abnormality of reticulocytes (HP:0004312)1.76409013
143Biliary tract neoplasm (HP:0100574)1.75920085
144Hypertensive crisis (HP:0100735)1.75382670
145Wormian bones (HP:0002645)1.75341686
146Neoplasm of the rectum (HP:0100743)1.75225668
147Aplasia/hypoplasia of the humerus (HP:0006507)1.74219357
148Back pain (HP:0003418)1.73786532
149Hyperparathyroidism (HP:0000843)1.73743181
150Intellectual disability, profound (HP:0002187)1.73709136
151Neoplasm of the heart (HP:0100544)1.73570997
152Gastrointestinal carcinoma (HP:0002672)1.73541227
153Malignant gastrointestinal tract tumors (HP:0006749)1.73541227
154Deformed sella turcica (HP:0002681)1.73436609
155Basal cell carcinoma (HP:0002671)1.72646869
156Subacute progressive viral hepatitis (HP:0006572)1.72609433
157High pitched voice (HP:0001620)1.71795382
158Flat cornea (HP:0007720)1.71530747
159Mildly elevated creatine phosphokinase (HP:0008180)1.71094242
160Deep palmar crease (HP:0006191)1.70641126
161Neoplasm of striated muscle (HP:0009728)1.69447962
162Abnormality of the 4th metacarpal (HP:0010012)1.67432363
163Lower limb amyotrophy (HP:0007210)1.66830582
164Interstitial pulmonary disease (HP:0006530)1.66681174
165Atrophic scars (HP:0001075)1.66454227
166Supranuclear gaze palsy (HP:0000605)1.65751483
167Radial bowing (HP:0002986)1.65411890
168Skin tags (HP:0010609)1.64987805
169Neoplasm of the pancreas (HP:0002894)1.64952130
170Supraventricular arrhythmia (HP:0005115)1.64649752
171Short phalanx of the thumb (HP:0009660)1.64402528
172Agammaglobulinemia (HP:0004432)1.63669209
173Ovarian neoplasm (HP:0100615)1.63663196
174Scapular winging (HP:0003691)1.62811193
175Fragile skin (HP:0001030)1.62612765
176Joint stiffness (HP:0001387)1.61456092
177Elevated alkaline phosphatase (HP:0003155)1.60654430
178Bone pain (HP:0002653)1.60500003
179Patellar dislocation (HP:0002999)1.58401949

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PKN25.68984610
2TRIB34.00060526
3EEF2K3.89961075
4SMG13.59624247
5NEK13.36692944
6PRPF4B3.23489899
7FLT32.97685296
8MAP4K12.46968034
9FGFR42.12204597
10NME22.11676160
11TSSK62.11581726
12MAP3K102.00890796
13KSR21.88058819
14MAP3K91.83212429
15CDC71.82709160
16SCYL21.81867244
17IRAK31.81205161
18BMX1.77751499
19PAK41.71723993
20TTN1.67311900
21RPS6KB21.66409584
22WEE11.64687990
23RIPK11.63015033
24MAP3K131.62585784
25TIE11.57301840
26BUB11.55801800
27EPHA21.55385767
28CAMK1D1.52641614
29NEK21.49019497
30ALK1.42147073
31SIK11.39326984
32PDGFRA1.38725581
33LATS21.37758404
34FGFR11.34440963
35PASK1.33131073
36CDK121.32744280
37MST1R1.32600786
38RIPK41.32312901
39TBK11.30791959
40MAP3K81.25345928
41SIK21.24719219
42MET1.19936267
43PRKD21.18454513
44TTK1.16556117
45PTK61.15940442
46LRRK21.14621047
47TGFBR11.09785981
48LMTK21.08969093
49KSR11.08067306
50TYK21.04908452
51PRKD31.02512352
52MAPKAPK31.01686379
53DAPK11.00502975
54CDK40.98697156
55ERN10.97582570
56DAPK30.96595592
57MAP3K140.95625237
58MTOR0.95051113
59BCKDK0.93097251
60MARK20.92693209
61ICK0.92189835
62PDPK10.91787117
63MAP3K10.90751430
64TESK20.89554272
65ILK0.89532155
66EPHB10.87267457
67PAK60.84940151
68KDR0.84454397
69PDK40.83698099
70PDK30.83698099
71MAPK110.83472869
72DYRK1B0.81839186
73PIM20.78167643
74AKT20.76754939
75PTK20.75399759
76CAMK1G0.75044208
77RET0.74747143
78JAK30.74617458
79PLK10.72493089
80HIPK20.71823514
81CSF1R0.71750462
82CDK70.71331288
83PAK20.68809507
84DDR20.68183558
85TNK20.65656917
86MAP3K30.65389344
87BLK0.65010061
88MAP3K60.64991853
89FER0.64104112
90ATR0.60754401
91TESK10.59715936
92CHEK10.59670124
93BTK0.59537382
94IRAK40.58869057
95TAOK20.58237163
96AURKB0.57913003
97MAP3K110.57473017
98SIK30.56874350
99PRKG20.56509212
100PAK10.56077444
101PDK10.55258866
102ZAP700.54601228
103RAF10.54210806
104STK100.52867221
105RPS6KA60.49530970
106TAOK10.48931458
107GRK60.48688667
108CAMKK10.48442548
109MATK0.48422269
110CDK20.47786924
111AURKA0.47255313
112MAP2K10.47221806
113MAP3K70.46260246
114EPHB20.46155063
115FGFR30.45723162
116MAPK120.44238584
117PLK30.44029098
118MAP2K30.43466699
119FES0.43388335
120DAPK20.43003305
121ARAF0.42032528
122BRAF0.41111684
123TYRO30.39744947
124LATS10.39735833
125JAK10.39731294
126CDK60.39205855
127RPS6KL10.38880488
128RPS6KC10.38880488
129MINK10.38689963
130FGR0.38051017
131RPS6KA10.37952485
132IKBKE0.36909799
133MAP2K20.36569602
134CAMK40.36446699
135MAPKAPK20.36281810
136PRKD10.36171853
137NEK90.36102095
138BRSK10.35938874
139MAPK40.34734340
140NTRK10.34258133
141CDK90.33627018
142CDK11A0.33551003
143EIF2AK10.33037060
144CAMK10.31312626
145RPS6KA20.30005481
146CDC42BPA0.29881604
147SRC0.29398225

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.80396420
2Other glycan degradation_Homo sapiens_hsa005113.38528587
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.02514981
4DNA replication_Homo sapiens_hsa030302.81171775
5Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.56588095
6* Central carbon metabolism in cancer_Homo sapiens_hsa052302.54405967
7* Biosynthesis of amino acids_Homo sapiens_hsa012302.52769700
8* Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.35828517
9* Carbon metabolism_Homo sapiens_hsa012002.28199929
10Mismatch repair_Homo sapiens_hsa034302.16919170
11One carbon pool by folate_Homo sapiens_hsa006702.07115799
12Glycosaminoglycan degradation_Homo sapiens_hsa005312.06020015
13* HIF-1 signaling pathway_Homo sapiens_hsa040661.93948147
14Spliceosome_Homo sapiens_hsa030401.89803403
15RNA transport_Homo sapiens_hsa030131.87361984
16B cell receptor signaling pathway_Homo sapiens_hsa046621.71972729
17Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.68811481
18Base excision repair_Homo sapiens_hsa034101.61040729
19Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.59785977
20Cell cycle_Homo sapiens_hsa041101.55039248
21Bladder cancer_Homo sapiens_hsa052191.51945462
22mTOR signaling pathway_Homo sapiens_hsa041501.47283420
23Thyroid cancer_Homo sapiens_hsa052161.36862900
24Lysosome_Homo sapiens_hsa041421.36480506
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.34356941
26* Fructose and mannose metabolism_Homo sapiens_hsa000511.32779435
27Pyruvate metabolism_Homo sapiens_hsa006201.26854345
28Chronic myeloid leukemia_Homo sapiens_hsa052201.24142617
29Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.21270939
30Prion diseases_Homo sapiens_hsa050201.20996983
31Leishmaniasis_Homo sapiens_hsa051401.17096613
32Ribosome_Homo sapiens_hsa030101.16340210
33Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.15517006
34mRNA surveillance pathway_Homo sapiens_hsa030151.14884214
35Oocyte meiosis_Homo sapiens_hsa041141.12627438
36Dilated cardiomyopathy_Homo sapiens_hsa054141.10928036
37Hepatitis C_Homo sapiens_hsa051601.10710870
38Osteoclast differentiation_Homo sapiens_hsa043801.09770937
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.07962535
40Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.07170675
41* Galactose metabolism_Homo sapiens_hsa000521.06086636
42Toxoplasmosis_Homo sapiens_hsa051451.05940479
43Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.05525751
44Leukocyte transendothelial migration_Homo sapiens_hsa046701.03658938
45Toll-like receptor signaling pathway_Homo sapiens_hsa046201.01446006
46Hippo signaling pathway_Homo sapiens_hsa043901.00991653
47Nucleotide excision repair_Homo sapiens_hsa034200.99397627
48Insulin signaling pathway_Homo sapiens_hsa049100.99286668
49Proteoglycans in cancer_Homo sapiens_hsa052050.98978858
50Thyroid hormone signaling pathway_Homo sapiens_hsa049190.98830616
51Non-small cell lung cancer_Homo sapiens_hsa052230.98180140
52Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.97517038
53Glioma_Homo sapiens_hsa052140.97417124
54Phospholipase D signaling pathway_Homo sapiens_hsa040720.97149057
55Notch signaling pathway_Homo sapiens_hsa043300.96530627
56Adherens junction_Homo sapiens_hsa045200.94705298
57Influenza A_Homo sapiens_hsa051640.93107902
58MicroRNAs in cancer_Homo sapiens_hsa052060.91637853
59Sulfur relay system_Homo sapiens_hsa041220.91550002
60Basal cell carcinoma_Homo sapiens_hsa052170.91513156
61Apoptosis_Homo sapiens_hsa042100.90569697
62* Glucagon signaling pathway_Homo sapiens_hsa049220.90530382
63Hepatitis B_Homo sapiens_hsa051610.88417265
64Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.87687950
65Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.86781609
66Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.86389495
67Viral carcinogenesis_Homo sapiens_hsa052030.85944258
68Endometrial cancer_Homo sapiens_hsa052130.85334249
69ErbB signaling pathway_Homo sapiens_hsa040120.85064376
70Shigellosis_Homo sapiens_hsa051310.84820016
71Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.84497249
72GnRH signaling pathway_Homo sapiens_hsa049120.84266090
73Colorectal cancer_Homo sapiens_hsa052100.83758896
74Staphylococcus aureus infection_Homo sapiens_hsa051500.83250638
75Vibrio cholerae infection_Homo sapiens_hsa051100.82271235
76HTLV-I infection_Homo sapiens_hsa051660.81287815
77Small cell lung cancer_Homo sapiens_hsa052220.81198044
78Choline metabolism in cancer_Homo sapiens_hsa052310.80846767
79Cyanoamino acid metabolism_Homo sapiens_hsa004600.80781633
80Tuberculosis_Homo sapiens_hsa051520.80223310
81VEGF signaling pathway_Homo sapiens_hsa043700.79858885
82Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.77353778
83Arginine biosynthesis_Homo sapiens_hsa002200.76719166
84Amoebiasis_Homo sapiens_hsa051460.75989102
85Acute myeloid leukemia_Homo sapiens_hsa052210.75508031
86Endocytosis_Homo sapiens_hsa041440.75050291
87Focal adhesion_Homo sapiens_hsa045100.74824734
88Cardiac muscle contraction_Homo sapiens_hsa042600.74752181
89Fatty acid biosynthesis_Homo sapiens_hsa000610.74706117
90Renin-angiotensin system_Homo sapiens_hsa046140.74578972
91Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.74356137
92Melanogenesis_Homo sapiens_hsa049160.74319589
93Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.74120738
94Salmonella infection_Homo sapiens_hsa051320.73959759
95* AMPK signaling pathway_Homo sapiens_hsa041520.73123975
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.72941130
97TNF signaling pathway_Homo sapiens_hsa046680.72660896
98Tight junction_Homo sapiens_hsa045300.72570917
99Renal cell carcinoma_Homo sapiens_hsa052110.72202350
100Allograft rejection_Homo sapiens_hsa053300.71774742
101Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.71683078
102Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71661550
103Estrogen signaling pathway_Homo sapiens_hsa049150.71650758
104Prolactin signaling pathway_Homo sapiens_hsa049170.71494943
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.70987265
106Herpes simplex infection_Homo sapiens_hsa051680.69910368
107Inositol phosphate metabolism_Homo sapiens_hsa005620.68050831
108Intestinal immune network for IgA production_Homo sapiens_hsa046720.67590897
109Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.67471494
110Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.67102132
111Pertussis_Homo sapiens_hsa051330.65079772
112Hedgehog signaling pathway_Homo sapiens_hsa043400.64730061
113Melanoma_Homo sapiens_hsa052180.63167472
114Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62198507
115NF-kappa B signaling pathway_Homo sapiens_hsa040640.61932136
116p53 signaling pathway_Homo sapiens_hsa041150.61179885
117Autoimmune thyroid disease_Homo sapiens_hsa053200.60794868
118Propanoate metabolism_Homo sapiens_hsa006400.60735323
119Lysine degradation_Homo sapiens_hsa003100.60653594
120Cysteine and methionine metabolism_Homo sapiens_hsa002700.59954033
121Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.59935468
122Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58553927
123RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.58464350
124Insulin resistance_Homo sapiens_hsa049310.57875338
125Pathways in cancer_Homo sapiens_hsa052000.57799447
126Gap junction_Homo sapiens_hsa045400.57788732
127Synaptic vesicle cycle_Homo sapiens_hsa047210.57604751
128Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56026300
129* Pentose phosphate pathway_Homo sapiens_hsa000300.55355945
130Primary immunodeficiency_Homo sapiens_hsa053400.55271216
131Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.54919279
132Phenylalanine metabolism_Homo sapiens_hsa003600.54224200
133Systemic lupus erythematosus_Homo sapiens_hsa053220.53826106
134Type II diabetes mellitus_Homo sapiens_hsa049300.53212766
135Alcoholism_Homo sapiens_hsa050340.52703217
136Platelet activation_Homo sapiens_hsa046110.52360525
137* RNA degradation_Homo sapiens_hsa030180.52081516
138Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51634578
139Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51435837
140PPAR signaling pathway_Homo sapiens_hsa033200.49510243
141Rap1 signaling pathway_Homo sapiens_hsa040150.49391483
142Phototransduction_Homo sapiens_hsa047440.49276053
143Phagosome_Homo sapiens_hsa041450.49116350
144Adipocytokine signaling pathway_Homo sapiens_hsa049200.48291023
145Legionellosis_Homo sapiens_hsa051340.46246583
146Viral myocarditis_Homo sapiens_hsa054160.43865178
147Long-term potentiation_Homo sapiens_hsa047200.43449617
148Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.41169376
149cGMP-PKG signaling pathway_Homo sapiens_hsa040220.41153505
150Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.39922500
151Pancreatic cancer_Homo sapiens_hsa052120.39835067
152AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.39686904
153Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39671018
154Oxytocin signaling pathway_Homo sapiens_hsa049210.39202337
155Fatty acid metabolism_Homo sapiens_hsa012120.38654099
156Pyrimidine metabolism_Homo sapiens_hsa002400.38561594

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