PFKFB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis. Multiple alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1actin-myosin filament sliding (GO:0033275)8.49897690
2muscle filament sliding (GO:0030049)8.49897690
3sarcoplasmic reticulum calcium ion transport (GO:0070296)7.83007625
4regulation of skeletal muscle contraction (GO:0014819)7.11077217
5skeletal muscle contraction (GO:0003009)6.98073905
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.96663625
7L-phenylalanine catabolic process (GO:0006559)6.96663625
8actin-mediated cell contraction (GO:0070252)6.96347665
9L-phenylalanine metabolic process (GO:0006558)6.79356200
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.79356200
11creatine metabolic process (GO:0006600)6.62778454
12aromatic amino acid family catabolic process (GO:0009074)6.33029683
13triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.00736414
14tryptophan catabolic process (GO:0006569)5.78743371
15indole-containing compound catabolic process (GO:0042436)5.78743371
16indolalkylamine catabolic process (GO:0046218)5.78743371
17exogenous drug catabolic process (GO:0042738)5.69915618
18kynurenine metabolic process (GO:0070189)5.69373033
19alpha-linolenic acid metabolic process (GO:0036109)5.61661321
20glyoxylate metabolic process (GO:0046487)5.50742877
21bile acid biosynthetic process (GO:0006699)5.43463313
22tryptophan metabolic process (GO:0006568)5.42513670
23urea metabolic process (GO:0019627)5.41799444
24urea cycle (GO:0000050)5.41799444
25response to muscle activity (GO:0014850)5.37447481
26glycogen catabolic process (GO:0005980)5.33206977
27negative regulation of fibrinolysis (GO:0051918)5.30097284
28NADH metabolic process (GO:0006734)5.28457040
29regulation of relaxation of muscle (GO:1901077)5.26458060
30complement activation, alternative pathway (GO:0006957)5.25712780
31response to stimulus involved in regulation of muscle adaptation (GO:0014874)5.23019283
32actin filament-based movement (GO:0030048)5.15335219
33sulfur amino acid catabolic process (GO:0000098)5.11208200
34high-density lipoprotein particle remodeling (GO:0034375)5.09636694
35regulation of protein activation cascade (GO:2000257)5.06724074
36serine family amino acid catabolic process (GO:0009071)5.04504592
37cysteine metabolic process (GO:0006534)5.04430705
38regulation of triglyceride catabolic process (GO:0010896)5.03725348
39regulation of fibrinolysis (GO:0051917)5.02511320
40peptidyl-glutamic acid carboxylation (GO:0017187)5.02013853
41protein carboxylation (GO:0018214)5.02013853
42glucan catabolic process (GO:0009251)4.99083006
43nitrogen cycle metabolic process (GO:0071941)4.98041556
44myofibril assembly (GO:0030239)4.94861289
45fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.90804262
46striated muscle contraction (GO:0006941)4.87514062
47positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.86389490
48lysine catabolic process (GO:0006554)4.78693885
49lysine metabolic process (GO:0006553)4.78693885
50skeletal muscle fiber development (GO:0048741)4.75002788
51regulation of complement activation (GO:0030449)4.74333704
52cellular polysaccharide catabolic process (GO:0044247)4.69375282
53bile acid metabolic process (GO:0008206)4.64380172
54aromatic amino acid family metabolic process (GO:0009072)4.61133120
55glycine metabolic process (GO:0006544)4.59979975
56triglyceride homeostasis (GO:0070328)4.59343250
57acylglycerol homeostasis (GO:0055090)4.59343250
58amino-acid betaine metabolic process (GO:0006577)4.59134509
59epoxygenase P450 pathway (GO:0019373)4.58383183
60oxaloacetate metabolic process (GO:0006107)4.55733622
61homocysteine metabolic process (GO:0050667)4.52273716
62alpha-amino acid catabolic process (GO:1901606)4.50480148
63plasma lipoprotein particle clearance (GO:0034381)4.49430631
64regulation of cholesterol esterification (GO:0010872)4.46664080
65reverse cholesterol transport (GO:0043691)4.42964035
66protein-lipid complex remodeling (GO:0034368)4.42366266
67macromolecular complex remodeling (GO:0034367)4.42366266
68plasma lipoprotein particle remodeling (GO:0034369)4.42366266
69tyrosine metabolic process (GO:0006570)4.42257871
70myotube cell development (GO:0014904)4.39716719
71glucan biosynthetic process (GO:0009250)4.35741365
72glycogen biosynthetic process (GO:0005978)4.35741365
73regulation of sequestering of triglyceride (GO:0010889)4.30531807
74skeletal muscle adaptation (GO:0043501)4.29118777
75omega-hydroxylase P450 pathway (GO:0097267)4.25611283
76sarcomere organization (GO:0045214)4.24521196
77cellular ketone body metabolic process (GO:0046950)4.23045473
78regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.22792594
79polysaccharide catabolic process (GO:0000272)4.21936458
80phospholipid efflux (GO:0033700)4.20629280
81acetyl-CoA metabolic process (GO:0006084)4.16293648
82serine family amino acid metabolic process (GO:0009069)4.15882897
83cellular amino acid catabolic process (GO:0009063)4.14882680
84negative regulation of cholesterol transport (GO:0032375)4.14447061
85negative regulation of sterol transport (GO:0032372)4.14447061
86response to mercury ion (GO:0046689)4.10502262
87response to inactivity (GO:0014854)4.07338137
88ethanol oxidation (GO:0006069)4.06956784
89muscle contraction (GO:0006936)4.03056695
90indolalkylamine metabolic process (GO:0006586)4.02695383
912-oxoglutarate metabolic process (GO:0006103)4.02223590
92coenzyme catabolic process (GO:0009109)4.01791797
93imidazole-containing compound metabolic process (GO:0052803)3.97764791
94arginine metabolic process (GO:0006525)3.95077081
95valine metabolic process (GO:0006573)3.93882864
96cellular biogenic amine catabolic process (GO:0042402)3.93496133
97amine catabolic process (GO:0009310)3.93496133
98plasma membrane repair (GO:0001778)3.93484753
99serine family amino acid biosynthetic process (GO:0009070)3.93142680
100positive regulation of fatty acid beta-oxidation (GO:0032000)3.92672372
101positive regulation of lipid catabolic process (GO:0050996)3.92067653
102carnitine shuttle (GO:0006853)3.91336117
103fatty acid beta-oxidation (GO:0006635)3.90322599
104bile acid and bile salt transport (GO:0015721)3.84505758
105phospholipid homeostasis (GO:0055091)3.83605120
106ethanol metabolic process (GO:0006067)3.82132092
107fatty acid oxidation (GO:0019395)3.78186326
108plasma lipoprotein particle assembly (GO:0034377)3.77090949
109triglyceride catabolic process (GO:0019433)3.76684945
110benzene-containing compound metabolic process (GO:0042537)3.76326492
111carboxylic acid catabolic process (GO:0046395)3.76018092
112organic acid catabolic process (GO:0016054)3.76018092
113cellular glucuronidation (GO:0052695)3.73926177
114fatty acid transmembrane transport (GO:1902001)3.73052653
115glycogen metabolic process (GO:0005977)3.72988574
116cholesterol efflux (GO:0033344)3.72762685
117fatty acid homeostasis (GO:0055089)3.70912409
118* gluconeogenesis (GO:0006094)3.70677263
119cardiac myofibril assembly (GO:0055003)3.70493369
120dicarboxylic acid biosynthetic process (GO:0043650)3.70222947
121lipid oxidation (GO:0034440)3.69852669
122cytolysis (GO:0019835)3.69431210
123glutamate metabolic process (GO:0006536)3.67347716
124fatty acid catabolic process (GO:0009062)3.67200940
125cellular glucan metabolic process (GO:0006073)3.64852956
126glucan metabolic process (GO:0044042)3.64852956
127cellular modified amino acid catabolic process (GO:0042219)3.64362807
128fibrinolysis (GO:0042730)3.62939601
129blood coagulation, intrinsic pathway (GO:0007597)3.62847369
130monocarboxylic acid catabolic process (GO:0072329)3.62453333
131ketone body metabolic process (GO:1902224)3.62276007
132aldehyde catabolic process (GO:0046185)3.62199689
133negative regulation of lipase activity (GO:0060192)3.62188582
134short-chain fatty acid metabolic process (GO:0046459)3.61396725
135negative regulation of fatty acid biosynthetic process (GO:0045717)3.59566697
136very-low-density lipoprotein particle assembly (GO:0034379)3.59346024
137cholesterol homeostasis (GO:0042632)3.58226971
138carnitine metabolic process (GO:0009437)3.57851823
139neutral lipid catabolic process (GO:0046461)3.56914892
140acylglycerol catabolic process (GO:0046464)3.56914892
141positive regulation of lipoprotein lipase activity (GO:0051006)3.56818009
142positive regulation of triglyceride lipase activity (GO:0061365)3.56818009
143muscle system process (GO:0003012)3.56549498
144aspartate family amino acid catabolic process (GO:0009068)3.56495426
145complement activation (GO:0006956)3.55267530
146complement activation, classical pathway (GO:0006958)3.54405044
147drug catabolic process (GO:0042737)3.54280794
148succinate metabolic process (GO:0006105)3.40456812
149actomyosin structure organization (GO:0031032)3.39580165
150* hexose biosynthetic process (GO:0019319)3.38624427
151cardiac muscle contraction (GO:0060048)3.36241642
152tricarboxylic acid cycle (GO:0006099)3.32266908
153drug metabolic process (GO:0017144)3.25309850
154muscle fiber development (GO:0048747)3.23255214
155skeletal muscle tissue development (GO:0007519)3.22102059
156regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.21555571
157oxidative demethylation (GO:0070989)3.17944175
158regulation of cell communication by electrical coupling (GO:0010649)3.12218767
159response to activity (GO:0014823)3.11829851
160striated muscle adaptation (GO:0014888)3.09057266
161cellular carbohydrate catabolic process (GO:0044275)3.07550785
162regulation of plasminogen activation (GO:0010755)3.06485054
163* fructose metabolic process (GO:0006000)2.99560204
164* monosaccharide biosynthetic process (GO:0046364)2.97313389
165cardiac muscle hypertrophy (GO:0003300)2.93602568
166skeletal muscle tissue regeneration (GO:0043403)2.93246384

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.59150086
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.78247259
3PPARA_22158963_ChIP-Seq_LIVER_Mouse6.66012575
4EGR1_23403033_ChIP-Seq_LIVER_Mouse6.25275002
5LXR_22158963_ChIP-Seq_LIVER_Mouse5.80129395
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.94530151
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.71721117
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.93603082
9BP1_19119308_ChIP-ChIP_Hs578T_Human3.71260355
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.55967202
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.14338869
12ESR1_20079471_ChIP-ChIP_T-47D_Human2.41025105
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.22449684
14CDX2_19796622_ChIP-Seq_MESCs_Mouse2.11207829
15* HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.09279369
16CLOCK_20551151_ChIP-Seq_293T_Human2.03339649
17ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.9590751
18TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.84348983
19PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.75055643
20STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.66599027
21EZH2_22144423_ChIP-Seq_EOC_Human1.65807933
22GATA1_22025678_ChIP-Seq_K562_Human1.61566141
23CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.54085625
24ESR2_21235772_ChIP-Seq_MCF-7_Human1.52944559
25ESR1_15608294_ChIP-ChIP_MCF-7_Human1.43266892
26EP300_21415370_ChIP-Seq_HL-1_Mouse1.40180457
27TRIM28_21343339_ChIP-Seq_HEK293_Human1.35261329
28EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.30917795
29ZNF263_19887448_ChIP-Seq_K562_Human1.28433082
30HNF4A_19822575_ChIP-Seq_HepG2_Human1.26300375
31STAT3_1855785_ChIP-Seq_MESCs_Mouse1.25975841
32EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.23993202
33STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.22105651
34CTCF_27219007_Chip-Seq_Bcells_Human1.21659374
35NFIB_24661679_ChIP-Seq_LUNG_Mouse1.20979703
36* FOXA2_19822575_ChIP-Seq_HepG2_Human1.20618582
37HTT_18923047_ChIP-ChIP_STHdh_Human1.19316314
38RXRA_24833708_ChIP-Seq_LIVER_Mouse1.14462746
39GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.13188165
40SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12351885
41NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.11289448
42MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.09716241
43TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.09575787
44MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.05602037
45ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.05417155
46RARG_19884340_ChIP-ChIP_MEFs_Mouse1.03616455
47THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.03605992
48AR_21909140_ChIP-Seq_LNCAP_Human1.02163920
49GATA4_21415370_ChIP-Seq_HL-1_Mouse1.01752820
50NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.00379914
51SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.99492132
52NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.96617069
53STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.95845124
54E2F7_22180533_ChIP-Seq_HELA_Human0.95253430
55PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.95221391
56DROSHA_22980978_ChIP-Seq_HELA_Human0.95008529
57LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.94699034
58DNAJC2_21179169_ChIP-ChIP_NT2_Human0.94208519
59IGF1R_20145208_ChIP-Seq_DFB_Human0.92859163
60MYC_27129775_Chip-Seq_CORNEA_Mouse0.91608518
61ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.90716966
62CBP_21632823_ChIP-Seq_H3396_Human0.90511841
63ESR1_21235772_ChIP-Seq_MCF-7_Human0.90390851
64RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87523471
65IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.87513284
66SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.86012846
67SA1_27219007_Chip-Seq_Bcells_Human0.85710980
68SMC3_22415368_ChIP-Seq_MEFs_Mouse0.85077900
69CRX_20693478_ChIP-Seq_RETINA_Mouse0.84985072
70CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.83219534
71ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.83026567
72E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.82662711
73TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81382341
74IRF8_22096565_ChIP-ChIP_GC-B_Human0.81163471
75GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.80516654
76OCT4_20526341_ChIP-Seq_ESCs_Human0.79959214
77AUTS2_25519132_ChIP-Seq_293T-REX_Human0.79599584
78NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.78844275
79NRF2_20460467_ChIP-Seq_MEFs_Mouse0.78844275
80PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.77285077
81SUZ12_27294783_Chip-Seq_NPCs_Mouse0.77168854
82SALL4_18804426_ChIP-ChIP_XEN_Mouse0.76863281
83RARA_24833708_ChIP-Seq_LIVER_Mouse0.76846886
84POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.76494676
85BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.76021362
86* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.75958299
87OCT4_21477851_ChIP-Seq_ESCs_Mouse0.74612721
88PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.74573255
89EZH2_27294783_Chip-Seq_NPCs_Mouse0.74431379
90CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.73969550
91GATA4_25053715_ChIP-Seq_YYC3_Human0.73849798
92SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.72059101
93SOX2_27498859_Chip-Seq_STOMACH_Mouse0.71645079
94KAP1_22055183_ChIP-Seq_ESCs_Mouse0.71190447
95CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.71086337
96RBPJ_22232070_ChIP-Seq_NCS_Mouse0.70155396
97CTCF_21964334_ChIP-Seq_BJAB-B_Human0.69648794
98ERG_21242973_ChIP-ChIP_JURKAT_Human0.69438772
99* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.68712373
100GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.67878875
101CEBPB_22108803_ChIP-Seq_LS180_Human0.67191534
102ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.65988245
103LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.65180981
104GATA6_21074721_ChIP-Seq_CACO-2_Human0.64719295
105PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.63842721
106PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.63769400
107RARB_24833708_ChIP-Seq_LIVER_Mouse0.63293974
108FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.63197256
109PHF8_20622853_ChIP-Seq_HELA_Human0.63181703
110CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.62322188
111P53_21459846_ChIP-Seq_SAOS-2_Human0.61151288
112E2F1_18555785_ChIP-Seq_MESCs_Mouse0.60199622
113SRF_21415370_ChIP-Seq_HL-1_Mouse0.59830920
114CREB1_15753290_ChIP-ChIP_HEK293T_Human0.58579185
115PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.57092894
116FOXM1_23109430_ChIP-Seq_U2OS_Human0.56204417
117MYC_18358816_ChIP-ChIP_MESCs_Mouse0.55141188
118MYC_18555785_ChIP-Seq_MESCs_Mouse0.54412327
119FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.53234032
120OCT4_18692474_ChIP-Seq_MEFs_Mouse0.52928473
121RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.52157071
122KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.51896914
123BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.51796592
124CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.51769436
125SOX2_18692474_ChIP-Seq_MEFs_Mouse0.51631479
126FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.49385977
127Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.48661069
128AR_20517297_ChIP-Seq_VCAP_Human0.48552499
129GATA6_25053715_ChIP-Seq_YYC3_Human0.47286226
130GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.46683166
131FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.46557400
132LXR_22292898_ChIP-Seq_THP-1_Human0.46504014
133FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.46123019
134GATA1_19941826_ChIP-Seq_K562_Human0.45671525
135ATF3_27146783_Chip-Seq_COLON_Human0.44723942
136TBX20_22080862_ChIP-Seq_HEART_Mouse0.44572078
137TBX20_22328084_ChIP-Seq_HEART_Mouse0.44572078
138BCOR_27268052_Chip-Seq_Bcells_Human0.43979631
139HIF1A_21447827_ChIP-Seq_MCF-7_Human0.43759183
140RAD21_21589869_ChIP-Seq_MESCs_Mouse0.43668875
141BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.43551508
142* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.43529871
143BCL6_27268052_Chip-Seq_Bcells_Human0.43331209
144NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.42817465
145TCF3_18692474_ChIP-Seq_MEFs_Mouse0.42807609
146NELFA_20434984_ChIP-Seq_ESCs_Mouse0.41938633
147BRD4_27068464_Chip-Seq_AML-cells_Mouse0.41894048
148GATA1_19941827_ChIP-Seq_MEL_Mouse0.41714424
149PPAR_26484153_Chip-Seq_NCI-H1993_Human0.41575966
150CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.40643007
151CTCF_21964334_Chip-Seq_Bcells_Human0.40173496
152TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.40074986
153GATA1_22383799_ChIP-Seq_G1ME_Mouse0.39641750
154SPI1_20517297_ChIP-Seq_HL60_Human0.39526398
155PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.39379347

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.50528427
2MP0005360_urolithiasis6.75847038
3MP0005085_abnormal_gallbladder_physiolo5.86604701
4MP0005365_abnormal_bile_salt5.69706165
5MP0004145_abnormal_muscle_electrophysio5.64940199
6MP0000751_myopathy5.07903038
7MP0008875_abnormal_xenobiotic_pharmacok4.48071314
8MP0003806_abnormal_nucleotide_metabolis4.36552005
9MP0010329_abnormal_lipoprotein_level3.61646472
10MP0003252_abnormal_bile_duct3.36663395
11MP0009840_abnormal_foam_cell3.09141753
12MP0002106_abnormal_muscle_physiology3.05591949
13MP0005083_abnormal_biliary_tract2.95601664
14MP0000759_abnormal_skeletal_muscle2.91509943
15MP0005369_muscle_phenotype2.61798991
16MP0005332_abnormal_amino_acid2.60245132
17MP0003191_abnormal_cellular_cholesterol2.51231132
18MP0004084_abnormal_cardiac_muscle2.26681384
19MP0001666_abnormal_nutrient_absorption2.25537750
20MP0003195_calcinosis2.25308220
21MP0004233_abnormal_muscle_weight2.25074596
22MP0000609_abnormal_liver_physiology2.24442394
23MP0005670_abnormal_white_adipose2.24389312
24MP0002118_abnormal_lipid_homeostasis2.14804884
25MP0000750_abnormal_muscle_regeneration2.10809026
26MP0005451_abnormal_body_composition1.96357159
27MP0005319_abnormal_enzyme/_coenzyme1.90727258
28MP0001764_abnormal_homeostasis1.80164298
29MP0004019_abnormal_vitamin_homeostasis1.78714300
30MP0009697_abnormal_copulation1.74960537
31MP0002108_abnormal_muscle_morphology1.74225119
32MP0003186_abnormal_redox_activity1.68393433
33MP0003705_abnormal_hypodermis_morpholog1.66627454
34MP0004130_abnormal_muscle_cell1.66450094
35MP0002972_abnormal_cardiac_muscle1.62681291
36MP0002138_abnormal_hepatobiliary_system1.62112845
37MP0000733_abnormal_muscle_development1.59733646
38MP0005584_abnormal_enzyme/coenzyme_acti1.52605544
39MP0003868_abnormal_feces_composition1.50396616
40MP0005666_abnormal_adipose_tissue1.48206080
41MP0000013_abnormal_adipose_tissue1.47910039
42MP0006036_abnormal_mitochondrial_physio1.42844599
43MP0002837_dystrophic_cardiac_calcinosis1.39155928
44MP0004215_abnormal_myocardial_fiber1.36193431
45MP0000598_abnormal_liver_morphology1.29070677
46MP0003656_abnormal_erythrocyte_physiolo1.29068225
47MP0000003_abnormal_adipose_tissue1.27855950
48MP0009780_abnormal_chondrocyte_physiolo1.18802647
49MP0003011_delayed_dark_adaptation1.18742170
50MP0002971_abnormal_brown_adipose1.18060355
51MP0009643_abnormal_urine_homeostasis1.16938881
52MP0004484_altered_response_of1.16805622
53MP0003950_abnormal_plasma_membrane1.16484419
54MP0003646_muscle_fatigue1.12831370
55MP0002127_abnormal_cardiovascular_syste1.10184921
56MP0004185_abnormal_adipocyte_glucose1.04300371
57MP0009763_increased_sensitivity_to1.03574639
58MP0005647_abnormal_sex_gland1.01975843
59MP0005334_abnormal_fat_pad1.00131668
60MP0005266_abnormal_metabolism0.96862309
61MP0005376_homeostasis/metabolism_phenot0.91011837
62MP0002269_muscular_atrophy0.89202931
63MP0002078_abnormal_glucose_homeostasis0.88739427
64MP0001661_extended_life_span0.87469531
65MP0002254_reproductive_system_inflammat0.85069453
66MP0006035_abnormal_mitochondrial_morpho0.84222234
67MP0010368_abnormal_lymphatic_system0.82848400
68MP0008469_abnormal_protein_level0.82376727
69MP0009642_abnormal_blood_homeostasis0.81093789
70MP0009764_decreased_sensitivity_to0.81092697
71MP0005167_abnormal_blood-brain_barrier0.80691498
72MP0003879_abnormal_hair_cell0.79420718
73MP0004510_myositis0.78591114
74MP0004270_analgesia0.77433571
75MP0009115_abnormal_fat_cell0.76778191
76MP0005408_hypopigmentation0.76719885
77MP0002876_abnormal_thyroid_physiology0.74812581
78MP0005636_abnormal_mineral_homeostasis0.74064470
79MP0005375_adipose_tissue_phenotype0.73342980
80MP0002970_abnormal_white_adipose0.73048332
81MP0005535_abnormal_body_temperature0.68399264
82MP0003828_pulmonary_edema0.66929668
83MP0005330_cardiomyopathy0.64432096
84MP0000604_amyloidosis0.63805834
85MP0003221_abnormal_cardiomyocyte_apopto0.62878526
86MP0003718_maternal_effect0.62835267
87MP0000749_muscle_degeneration0.62365036
88MP0004147_increased_porphyrin_level0.62033819
89MP0009765_abnormal_xenobiotic_induced0.61788830
90MP0009053_abnormal_anal_canal0.61328858
91MP0009672_abnormal_birth_weight0.59996597
92MP0005448_abnormal_energy_balance0.59723002
93MP0002822_catalepsy0.59485868
94MP0001756_abnormal_urination0.58380960
95MP0001853_heart_inflammation0.58254979
96MP0002638_abnormal_pupillary_reflex0.57575581
97MP0005084_abnormal_gallbladder_morpholo0.57168020
98MP0004036_abnormal_muscle_relaxation0.53795262
99MP0002332_abnormal_exercise_endurance0.53250564
100MP0005464_abnormal_platelet_physiology0.53018864
101MP0004087_abnormal_muscle_fiber0.51583244
102MP0005395_other_phenotype0.50235581
103MP0002796_impaired_skin_barrier0.49381496
104MP0003137_abnormal_impulse_conducting0.47981821
105MP0003436_decreased_susceptibility_to0.47553863
106MP0003045_fibrosis0.47165886
107MP0005166_decreased_susceptibility_to0.47081731
108MP0003959_abnormal_lean_body0.46027151
109MP0005220_abnormal_exocrine_pancreas0.44801619
110MP0000747_muscle_weakness0.44534846
111MP0003690_abnormal_glial_cell0.44170240
112MP0000266_abnormal_heart_morphology0.43960857
113MP0002132_abnormal_respiratory_system0.43726512
114MP0004043_abnormal_pH_regulation0.43237109
115MP0001544_abnormal_cardiovascular_syste0.41781206
116MP0005385_cardiovascular_system_phenoty0.41781206
117MP0001243_abnormal_dermal_layer0.41444729
118MP0002128_abnormal_blood_circulation0.41058995
119MP0004085_abnormal_heartbeat0.40009421
120MP0008873_increased_physiological_sensi0.39878868
121MP0003948_abnormal_gas_homeostasis0.39503406
122MP0008775_abnormal_heart_ventricle0.39329497
123MP0006138_congestive_heart_failure0.38854444
124MP0005620_abnormal_muscle_contractility0.38831711
125MP0002136_abnormal_kidney_physiology0.38679870
126MP0001881_abnormal_mammary_gland0.38425880
127MP0005452_abnormal_adipose_tissue0.37775285
128MP0000249_abnormal_blood_vessel0.37136951
129MP0005023_abnormal_wound_healing0.37036992
130MP0003953_abnormal_hormone_level0.36351576
131MP0010630_abnormal_cardiac_muscle0.35835369
132MP0003724_increased_susceptibility_to0.35521513
133MP0000639_abnormal_adrenal_gland0.35279956
134MP0002060_abnormal_skin_morphology0.33553670
135MP0000427_abnormal_hair_cycle0.30697947

Predicted human phenotypes

RankGene SetZ-score
1Nemaline bodies (HP:0003798)9.99232769
2Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)9.66034367
3Type 1 muscle fiber predominance (HP:0003803)7.36533114
4Exercise-induced muscle cramps (HP:0003710)7.00581614
5Deep venous thrombosis (HP:0002625)6.51724218
6Abnormality of aromatic amino acid family metabolism (HP:0004338)6.42994768
7Intrahepatic cholestasis (HP:0001406)6.30516000
8Abnormality of monocarboxylic acid metabolism (HP:0010996)6.02962381
9Hypobetalipoproteinemia (HP:0003563)5.84723850
10Prolonged partial thromboplastin time (HP:0003645)5.69385862
11Xanthomatosis (HP:0000991)5.69040056
12Muscle hypertrophy of the lower extremities (HP:0008968)5.64491962
13Distal arthrogryposis (HP:0005684)5.24428189
14Myopathic facies (HP:0002058)5.23203681
15Hyperlipoproteinemia (HP:0010980)5.09750101
16Complement deficiency (HP:0004431)5.07137590
17Calf muscle hypertrophy (HP:0008981)4.87019633
18Hyperammonemia (HP:0001987)4.73832575
19Hypolipoproteinemia (HP:0010981)4.73399949
20EMG: myopathic abnormalities (HP:0003458)4.72609037
21Muscle fiber splitting (HP:0003555)4.55095336
22Round ear (HP:0100830)4.53857648
23Epidermoid cyst (HP:0200040)4.52960735
24Hypoglycemic coma (HP:0001325)4.49728676
25Hyperglycinemia (HP:0002154)4.47459993
26Hypoalphalipoproteinemia (HP:0003233)4.42387530
27Hyperglycinuria (HP:0003108)4.41037683
28Ketosis (HP:0001946)4.38519841
29Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.34974394
30Joint hemorrhage (HP:0005261)4.30374594
31Abnormality of serine family amino acid metabolism (HP:0010894)4.19843704
32Abnormality of glycine metabolism (HP:0010895)4.19843704
33Ulnar deviation of the wrist (HP:0003049)4.19571668
34Hyporeflexia of lower limbs (HP:0002600)4.16153606
35Abnormality of methionine metabolism (HP:0010901)4.11259511
36Abnormality of skeletal muscle fiber size (HP:0012084)4.09950344
37Rimmed vacuoles (HP:0003805)4.07293047
38Neck muscle weakness (HP:0000467)4.02999010
39Abnormality of sulfur amino acid metabolism (HP:0004339)3.96794200
40Abnormality of the common coagulation pathway (HP:0010990)3.91828575
41Abnormality of aspartate family amino acid metabolism (HP:0010899)3.89549838
42Difficulty running (HP:0009046)3.88581053
43Centrally nucleated skeletal muscle fibers (HP:0003687)3.87657236
44Abnormality of the calf musculature (HP:0001430)3.84493344
45Muscle stiffness (HP:0003552)3.82778586
46Abnormality of fatty-acid metabolism (HP:0004359)3.79238809
47Abnormality of pyrimidine metabolism (HP:0004353)3.78695439
48Abnormality of glutamine family amino acid metabolism (HP:0010902)3.78544448
49Increased connective tissue (HP:0009025)3.72351778
50Abnormality of complement system (HP:0005339)3.69947972
51Subaortic stenosis (HP:0001682)3.52633676
52Abnormality of the left ventricular outflow tract (HP:0011103)3.52633676
53Increased variability in muscle fiber diameter (HP:0003557)3.50789306
54Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.49354373
55Fat malabsorption (HP:0002630)3.47009570
56Calcaneovalgus deformity (HP:0001848)3.45817389
57Abnormality of the intrinsic pathway (HP:0010989)3.41019556
58Dicarboxylic aciduria (HP:0003215)3.32856997
59Abnormality of dicarboxylic acid metabolism (HP:0010995)3.32856997
60Abnormality of serum amino acid levels (HP:0003112)3.28124722
61Ketoacidosis (HP:0001993)3.27887097
62Absent phalangeal crease (HP:0006109)3.27389843
63Hypercholesterolemia (HP:0003124)3.23663096
64Myotonia (HP:0002486)3.19612094
65Distal lower limb muscle weakness (HP:0009053)3.18476992
66Frequent falls (HP:0002359)3.14385866
67Hyperbilirubinemia (HP:0002904)3.13307959
68Asymmetric septal hypertrophy (HP:0001670)3.11086477
69Abnormality of nucleobase metabolism (HP:0010932)3.03149646
70Deformed tarsal bones (HP:0008119)3.02570703
71Hypochromic microcytic anemia (HP:0004840)3.01212066
72Malignant hyperthermia (HP:0002047)2.92071707
73Myocardial infarction (HP:0001658)2.87688038
74Myoglobinuria (HP:0002913)2.85878080
75Lethargy (HP:0001254)2.85586861
76Cerebral edema (HP:0002181)2.81335721
77Delayed CNS myelination (HP:0002188)2.78596869
78Metabolic acidosis (HP:0001942)2.78519692
79Cholelithiasis (HP:0001081)2.75085586
80Areflexia of lower limbs (HP:0002522)2.75018194
81Hepatocellular carcinoma (HP:0001402)2.72744235
82Abnormal gallbladder morphology (HP:0012437)2.70819551
83Spontaneous abortion (HP:0005268)2.70099092
84Skin nodule (HP:0200036)2.68940539
85Abnormal finger flexion creases (HP:0006143)2.67977423
86Conjugated hyperbilirubinemia (HP:0002908)2.67001966
87Steatorrhea (HP:0002570)2.66975606
88Abnormality of purine metabolism (HP:0004352)2.65376750
89Rhabdomyolysis (HP:0003201)2.63727601
90EMG: neuropathic changes (HP:0003445)2.61189458
91Nausea (HP:0002018)2.56244539
92Generalized aminoaciduria (HP:0002909)2.52555305
93Sudden death (HP:0001699)2.51895788
94Generalized muscle weakness (HP:0003324)2.46097452
95Systemic lupus erythematosus (HP:0002725)2.43423474
96Spastic diplegia (HP:0001264)2.41750996
97Bulbar palsy (HP:0001283)2.39869329
98Bundle branch block (HP:0011710)2.39629312
99Oligomenorrhea (HP:0000876)2.39531141
100Mildly elevated creatine phosphokinase (HP:0008180)2.34385783
101Gowers sign (HP:0003391)2.33718867
102Cholecystitis (HP:0001082)2.33663182
103Abnormal gallbladder physiology (HP:0012438)2.33663182
104Hypertriglyceridemia (HP:0002155)2.31582233
105Renal cortical cysts (HP:0000803)2.30366847
106Distal lower limb amyotrophy (HP:0008944)2.26630732
107Gout (HP:0001997)2.24666985
108Hyperkalemia (HP:0002153)2.24346058
109Vomiting (HP:0002013)2.20850811
110Neonatal onset (HP:0003623)2.20146177
111Hypoglycemic seizures (HP:0002173)2.19932543
112Pancreatitis (HP:0001733)2.16733841
113Slender build (HP:0001533)2.16539450
114Dilated cardiomyopathy (HP:0001644)2.13039439
115Late onset (HP:0003584)2.12264664
116Acanthocytosis (HP:0001927)2.11488887
117Hyperglycemia (HP:0003074)2.11013494
118Esophageal varix (HP:0002040)2.08405831
119Spinal rigidity (HP:0003306)2.08344469
120Abnormality of the gallbladder (HP:0005264)2.07595062
121Proximal tubulopathy (HP:0000114)2.07486584
122Recurrent gram-negative bacterial infections (HP:0005420)2.07210167
123Irritability (HP:0000737)2.06355982
124Scapular winging (HP:0003691)2.05860566
125Limb-girdle muscle atrophy (HP:0003797)2.05675065
126Abnormal cartilage morphology (HP:0002763)2.03336502
127Poikilocytosis (HP:0004447)2.02169067
128Vascular calcification (HP:0004934)2.01625547
129Abnormality of the calcaneus (HP:0008364)2.01124455
130Fetal akinesia sequence (HP:0001989)2.01102423
131Weak cry (HP:0001612)2.00094813
132Muscle fiber inclusion bodies (HP:0100299)10.2108515
133Paralysis (HP:0003470)1.99402535
134Hyperinsulinemic hypoglycemia (HP:0000825)1.99367702
135Heart block (HP:0012722)1.96766720
136Increased serum pyruvate (HP:0003542)1.96693578
137Abnormality of glycolysis (HP:0004366)1.96693578
138Brushfield spots (HP:0001088)1.95786084
139Abnormality of iron homeostasis (HP:0011031)1.95437941
140Opisthotonus (HP:0002179)1.94170862
141Abnormality of the neuromuscular junction (HP:0003398)1.93994310
142Fatigable weakness (HP:0003473)1.93994310
143Abnormality of proline metabolism (HP:0010907)1.93852207
144Hydroxyprolinuria (HP:0003080)1.93852207
145Progressive muscle weakness (HP:0003323)1.93099557
146Hemorrhage of the eye (HP:0011885)1.92517486
147Gingival bleeding (HP:0000225)1.92208564
148Malnutrition (HP:0004395)1.91781949
149Ventricular tachycardia (HP:0004756)1.91050814
150Exercise-induced myalgia (HP:0003738)1.89789641
151Thrombophlebitis (HP:0004418)1.88853523
152Abnormality of transition element cation homeostasis (HP:0011030)1.87876847
153Reticulocytosis (HP:0001923)1.87375069
154Glomerulonephritis (HP:0000099)1.87211676
155Menorrhagia (HP:0000132)1.86542293
156Abnormal atrioventricular conduction (HP:0005150)1.84739996
157Lipoatrophy (HP:0100578)1.83959057
158Enlarged kidneys (HP:0000105)1.83695852
159Increased purine levels (HP:0004368)1.82929307
160Hyperuricemia (HP:0002149)1.82929307
161Hepatic necrosis (HP:0002605)1.82671969
162Abnormality of the foot musculature (HP:0001436)1.77767286
163Waddling gait (HP:0002515)1.77728138
164Hip contracture (HP:0003273)1.77457559
165Muscular dystrophy (HP:0003560)1.75599776
166Ragged-red muscle fibers (HP:0003200)1.74710388
167Proximal amyotrophy (HP:0007126)1.74515966
168Increased muscle lipid content (HP:0009058)1.72255450
169Exercise intolerance (HP:0003546)1.70703666
170Difficulty climbing stairs (HP:0003551)1.66884188
171Foot dorsiflexor weakness (HP:0009027)1.64339347
172Abnormality of the shoulder girdle musculature (HP:0001435)1.62401574
173Lower limb amyotrophy (HP:0007210)1.60077338
174Respiratory insufficiency due to muscle weakness (HP:0002747)1.58747826
175Facial diplegia (HP:0001349)1.57290466

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.05642292
2SIK13.86303692
3ERN13.39568005
4FGFR43.39061819
5TRIB32.83079671
6OBSCN2.67311704
7PKN22.57143695
8NEK12.11559322
9ERBB42.09481047
10NEK92.03685591
11MAPK111.90513474
12TTN1.90452857
13PDK41.87897089
14PDK31.87897089
15LATS11.87228016
16FLT31.80925833
17MAP2K31.80629136
18PIK3CG1.78344360
19CAMK1D1.66990357
20INSRR1.58644986
21MAP2K41.54531753
22PINK11.51867968
23TYK21.50964170
24TAOK31.47577436
25STK38L1.39804746
26PRKAA21.39076483
27MST1R1.31016270
28MUSK1.30060405
29EEF2K1.25754382
30KDR1.24125471
31RIPK11.23640482
32ABL21.22595567
33TRPM71.07760808
34PHKG21.06552450
35PHKG11.06552450
36EIF2AK11.04419543
37PTK61.03155999
38JAK21.01363417
39CDK41.00946958
40CDK60.98946542
41LATS20.97640551
42MAP3K70.91105962
43MAPK120.90579830
44PIK3CA0.88447014
45PDK20.88130536
46PRKAA10.88126568
47MAP3K130.86467937
48ICK0.85839861
49MAPKAPK30.85020175
50MAP3K30.83915154
51MOS0.83857733
52NME10.83168887
53DYRK1B0.79379328
54MAP2K60.78781621
55MARK10.75143352
56MAP3K100.68343561
57FGFR30.66201628
58MAPK40.65898055
59CCNB10.65730090
60MAPK70.64969508
61NEK20.64255911
62CAMK40.63969986
63ERBB20.62735520
64CAMK10.61788366
65TTK0.61713029
66BUB10.61536521
67JAK10.61093501
68IKBKE0.60758303
69LIMK10.60574144
70TIE10.59840610
71CDC70.59820630
72ACVR1B0.59293199
73MTOR0.58882791
74EPHA30.58761981
75TBK10.55871132
76TAOK20.55180823
77ERBB30.55147454
78FRK0.55074573
79MAP3K80.54212584
80GRK60.54109181
81CAMK1G0.54015900
82* PRKG10.53916972
83LMTK20.53373094
84DMPK0.52699611
85MAP3K110.52029215
86* PRKACG0.51977049
87IRAK30.49480449
88SGK20.48149872
89STK30.47836990
90KSR20.44634530
91PKN10.44456257
92MET0.43560066
93NME20.43363582
94CSF1R0.42314424
95PDPK10.42299326
96FGFR20.41600225
97PRKACA0.40791522
98EPHA20.40133884
99RPS6KA40.38747066
100RPS6KB20.37550874
101TGFBR20.37524188
102PTK20.36915184
103GSK3A0.36714896
104PLK40.36521533
105CAMK2D0.36061975
106WEE10.36058717
107MAP3K10.35762051
108CDK120.35429459
109PRPF4B0.35412883
110RPS6KA30.35136038
111CAMK2B0.34657669
112DAPK20.34487584
113MAP3K50.34475484
114MAP2K10.34215908
115EIF2AK30.34174605
116STK40.33761538
117PIM10.33627791
118SGK10.32395797
119SGK30.31947688
120MAP4K10.31810858
121CAMK2G0.31125178
122PRKACB0.30348153
123AKT20.30044884
124NLK0.29945711
125EPHB10.29704057
126CAMK2A0.29381938
127TNK20.29348080
128PLK10.28805349
129ROCK10.28382650
130PRKCZ0.28235807
131SGK4940.27966738
132SGK2230.27966738
133PDK10.27722639
134MAP3K60.26695175
135MELK0.26147986
136STK100.26018080
137ARAF0.24517824
138FGFR10.24025042
139RPS6KB10.23108453
140MAPK100.22686485
141PRKG20.18724166
142MAPK130.15374045
143ZAP700.13437709
144PRKD10.12628658
145MAPK30.11408099
146MARK20.10067942
147PDGFRA0.09126857
148IGF1R0.08567875
149DDR20.07633625
150RPS6KA10.06423426
151STK110.05736472

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.14298218
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.37523710
3Nitrogen metabolism_Homo sapiens_hsa009103.13759167
4Arginine biosynthesis_Homo sapiens_hsa002202.93140939
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.93109376
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.84375922
7Fatty acid degradation_Homo sapiens_hsa000712.70749033
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.65481045
9Tryptophan metabolism_Homo sapiens_hsa003802.60291195
10Complement and coagulation cascades_Homo sapiens_hsa046102.55369934
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.54245005
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.47293494
13Propanoate metabolism_Homo sapiens_hsa006402.42725378
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.18969604
15PPAR signaling pathway_Homo sapiens_hsa033202.14287169
16Fatty acid metabolism_Homo sapiens_hsa012122.06013465
17Peroxisome_Homo sapiens_hsa041462.05270661
18Butanoate metabolism_Homo sapiens_hsa006502.05061750
19Pentose and glucuronate interconversions_Homo sapiens_hsa000402.04260311
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.91251448
21beta-Alanine metabolism_Homo sapiens_hsa004101.79192777
22Caffeine metabolism_Homo sapiens_hsa002321.78760249
23Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.77255879
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.76462149
25Chemical carcinogenesis_Homo sapiens_hsa052041.75393826
26Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.72906906
27Pyruvate metabolism_Homo sapiens_hsa006201.69212999
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.68406201
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.61348609
30Histidine metabolism_Homo sapiens_hsa003401.61327828
31Staphylococcus aureus infection_Homo sapiens_hsa051501.60034171
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.59445450
33Carbon metabolism_Homo sapiens_hsa012001.59040207
34Phenylalanine metabolism_Homo sapiens_hsa003601.58476928
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.56448283
36Selenocompound metabolism_Homo sapiens_hsa004501.55076273
37Biosynthesis of amino acids_Homo sapiens_hsa012301.51409570
38Dilated cardiomyopathy_Homo sapiens_hsa054141.51112238
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.49909266
40Retinol metabolism_Homo sapiens_hsa008301.46584840
41Cardiac muscle contraction_Homo sapiens_hsa042601.44282794
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.41989530
43Tyrosine metabolism_Homo sapiens_hsa003501.41324388
44Starch and sucrose metabolism_Homo sapiens_hsa005001.40282651
45Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.38322033
46Fatty acid elongation_Homo sapiens_hsa000621.26269436
47Folate biosynthesis_Homo sapiens_hsa007901.23303374
48Fat digestion and absorption_Homo sapiens_hsa049751.22696655
49Bile secretion_Homo sapiens_hsa049761.20271603
50Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.13989311
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.13550612
52One carbon pool by folate_Homo sapiens_hsa006701.10270381
53ABC transporters_Homo sapiens_hsa020101.08703526
54Vitamin B6 metabolism_Homo sapiens_hsa007501.07294784
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.97352766
56Arginine and proline metabolism_Homo sapiens_hsa003300.95565029
57Sulfur metabolism_Homo sapiens_hsa009200.92838734
58Sulfur relay system_Homo sapiens_hsa041220.92267741
59Steroid biosynthesis_Homo sapiens_hsa001000.89099515
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.88469232
61Fatty acid biosynthesis_Homo sapiens_hsa000610.88153476
62Cyanoamino acid metabolism_Homo sapiens_hsa004600.87025183
63Pentose phosphate pathway_Homo sapiens_hsa000300.83936200
64Lysine degradation_Homo sapiens_hsa003100.83075616
65Glycerolipid metabolism_Homo sapiens_hsa005610.81389192
66Vitamin digestion and absorption_Homo sapiens_hsa049770.72030347
67Glutathione metabolism_Homo sapiens_hsa004800.71225005
68Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.69338155
69Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.69126021
70Maturity onset diabetes of the young_Homo sapiens_hsa049500.67689254
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.56813234
72Oxytocin signaling pathway_Homo sapiens_hsa049210.52781483
73Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.50993391
74Metabolic pathways_Homo sapiens_hsa011000.50565421
75Calcium signaling pathway_Homo sapiens_hsa040200.50217411
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.46364316
77Galactose metabolism_Homo sapiens_hsa000520.44821232
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.41326671
79Insulin resistance_Homo sapiens_hsa049310.40923042
80cGMP-PKG signaling pathway_Homo sapiens_hsa040220.40165020
81Alzheimers disease_Homo sapiens_hsa050100.32989863
82* Fructose and mannose metabolism_Homo sapiens_hsa000510.32477933
83alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32471835
84Parkinsons disease_Homo sapiens_hsa050120.28607247
85* AMPK signaling pathway_Homo sapiens_hsa041520.27398074
86Linoleic acid metabolism_Homo sapiens_hsa005910.26970967
87* Glucagon signaling pathway_Homo sapiens_hsa049220.24130015
88Prion diseases_Homo sapiens_hsa050200.19170658
89Renin secretion_Homo sapiens_hsa049240.17616980
90Glycerophospholipid metabolism_Homo sapiens_hsa005640.17550847
91Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.15627285
92Tight junction_Homo sapiens_hsa045300.11035191
93Insulin signaling pathway_Homo sapiens_hsa049100.10672830
94FoxO signaling pathway_Homo sapiens_hsa040680.10589364
95Oxidative phosphorylation_Homo sapiens_hsa001900.10463442
96Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.07018368
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.06126015
98Pertussis_Homo sapiens_hsa051330.04953477
99Long-term potentiation_Homo sapiens_hsa047200.04149872
100Gastric acid secretion_Homo sapiens_hsa049710.03752072
101Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.02410924
102Central carbon metabolism in cancer_Homo sapiens_hsa052300.01369575
103Focal adhesion_Homo sapiens_hsa045100.00781859
104Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.2237037
105Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2204598
106Purine metabolism_Homo sapiens_hsa00230-0.2169037
107Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923-0.2067870
108Circadian rhythm_Homo sapiens_hsa04710-0.2066482
109RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.1998406
110Mismatch repair_Homo sapiens_hsa03430-0.1935007
111Hepatitis C_Homo sapiens_hsa05160-0.1875480
112Regulation of autophagy_Homo sapiens_hsa04140-0.1611047
113Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.1321411
114Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1247934
115Proteasome_Homo sapiens_hsa03050-0.1147909
116Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.1132294
117Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1049170
118Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0172760
119Pyrimidine metabolism_Homo sapiens_hsa00240-0.0137289

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