PFDN6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: PFDN6 is a subunit of the heteromeric prefoldin complex that chaperones nascent actin (see MIM 102560) and alpha- and beta-tubulin (see MIM 602529 and MIM 191130, respectively) chains pending their transfer to the cytosolic chaperonin containing TCP1 (MIM 186980) (CCT) complex (Hansen et al., 1999 [PubMed 10209023]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.09234747
2viral transcription (GO:0019083)5.41024215
3translational termination (GO:0006415)5.26583475
4ribosomal small subunit biogenesis (GO:0042274)5.23457463
5maturation of SSU-rRNA (GO:0030490)5.19818702
6ribosomal small subunit assembly (GO:0000028)5.10472887
7proteasome assembly (GO:0043248)4.94482508
8ribosomal large subunit biogenesis (GO:0042273)4.91521859
9regulation of translational fidelity (GO:0006450)4.75378471
10translational elongation (GO:0006414)4.73678628
11mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.66301923
12proline biosynthetic process (GO:0006561)4.59170647
13SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.59103909
14DNA unwinding involved in DNA replication (GO:0006268)4.58261154
15transcription elongation from RNA polymerase III promoter (GO:0006385)4.55081427
16termination of RNA polymerase III transcription (GO:0006386)4.55081427
17cotranslational protein targeting to membrane (GO:0006613)4.53830463
18translational initiation (GO:0006413)4.51162310
19protein targeting to ER (GO:0045047)4.50163421
20ribonucleoprotein complex biogenesis (GO:0022613)4.41059057
21establishment of protein localization to mitochondrial membrane (GO:0090151)4.39105890
22energy coupled proton transport, down electrochemical gradient (GO:0015985)4.37594801
23ATP synthesis coupled proton transport (GO:0015986)4.37594801
24negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.34792079
25spliceosomal snRNP assembly (GO:0000387)4.34135856
26cellular protein complex disassembly (GO:0043624)4.30128334
27protein localization to endoplasmic reticulum (GO:0070972)4.28947083
28negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.26154618
29establishment of protein localization to endoplasmic reticulum (GO:0072599)4.26136348
30viral life cycle (GO:0019058)4.19691293
31mitotic chromosome condensation (GO:0007076)4.18826547
32nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.14521782
33DNA strand elongation involved in DNA replication (GO:0006271)4.12671080
34translation (GO:0006412)4.11159174
35formation of translation preinitiation complex (GO:0001731)4.07966092
36COPI coating of Golgi vesicle (GO:0048205)4.04835269
37Golgi transport vesicle coating (GO:0048200)4.04835269
38telomere maintenance via semi-conservative replication (GO:0032201)4.04465569
39positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.01538346
40ribosome biogenesis (GO:0042254)3.98783500
417-methylguanosine mRNA capping (GO:0006370)3.97971058
42spliceosomal complex assembly (GO:0000245)3.96946677
43nucleobase biosynthetic process (GO:0046112)3.96925328
44rRNA processing (GO:0006364)3.96892734
45negative regulation of ligase activity (GO:0051352)3.94171409
46negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.94171409
47regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.93616707
48anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.93370746
49DNA strand elongation (GO:0022616)3.91227312
50purine nucleobase biosynthetic process (GO:0009113)3.88701779
517-methylguanosine RNA capping (GO:0009452)3.88648014
52RNA capping (GO:0036260)3.88648014
53chaperone-mediated protein transport (GO:0072321)3.87162910
54pseudouridine synthesis (GO:0001522)3.87136864
55rRNA metabolic process (GO:0016072)3.85484195
56histone H2B ubiquitination (GO:0033523)3.85024423
57cellular component biogenesis (GO:0044085)3.83186308
58regulation of early endosome to late endosome transport (GO:2000641)3.81653149
59regulation of mammary gland epithelial cell proliferation (GO:0033599)3.80518782
60nucleobase-containing small molecule interconversion (GO:0015949)3.79065635
61protein complex disassembly (GO:0043241)3.79050165
62regulation of cellular amino acid metabolic process (GO:0006521)3.76204537
63rRNA modification (GO:0000154)3.74583218
64positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling3.73958942
65nuclear pore complex assembly (GO:0051292)3.73693077
66spliceosomal tri-snRNP complex assembly (GO:0000244)3.72933567
67DNA replication initiation (GO:0006270)3.72206187
68DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.71592402
69regulation of mitochondrial translation (GO:0070129)3.69993602
70heterochromatin organization (GO:0070828)3.69090747
71DNA replication checkpoint (GO:0000076)3.67995176
72protein maturation by protein folding (GO:0022417)3.66976414
73protein retention in ER lumen (GO:0006621)3.66800807
74transcription-coupled nucleotide-excision repair (GO:0006283)3.66573040
75establishment of protein localization to mitochondrion (GO:0072655)3.65332132
76intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.64716871
77signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.64716871
78protein targeting to mitochondrion (GO:0006626)3.64468084
79macromolecular complex disassembly (GO:0032984)3.64022668
80signal transduction involved in DNA integrity checkpoint (GO:0072401)3.63800372
81signal transduction involved in DNA damage checkpoint (GO:0072422)3.63800372
82signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.63586979
83signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.63586979
84signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.63586979
85mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.63011495
86ribosome assembly (GO:0042255)3.62265366
87signal transduction involved in cell cycle checkpoint (GO:0072395)3.59567020
88L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.58895421
89positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.56124523
90maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.55603113
91establishment of integrated proviral latency (GO:0075713)3.54522659
92telomere maintenance via recombination (GO:0000722)3.53403656
93exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.51651343
94protein neddylation (GO:0045116)3.50083199
95nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.49524491
96transcription from RNA polymerase I promoter (GO:0006360)3.44470829
97positive regulation of ligase activity (GO:0051351)3.39775567
98transcription elongation from RNA polymerase I promoter (GO:0006362)3.38797431
99antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.37125040
100protein localization to mitochondrion (GO:0070585)3.35472567
101cullin deneddylation (GO:0010388)3.34263779
102viral mRNA export from host cell nucleus (GO:0046784)3.32560936
1033-UTR-mediated mRNA stabilization (GO:0070935)3.30678212
104retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.30400213
105respiratory electron transport chain (GO:0022904)3.30356351
106nuclear-transcribed mRNA catabolic process (GO:0000956)3.26904350
107termination of RNA polymerase I transcription (GO:0006363)3.26861152
108negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.26682680
109protein deneddylation (GO:0000338)3.25390822
110protein targeting to membrane (GO:0006612)3.25189831
111negative regulation of DNA-templated transcription, elongation (GO:0032785)3.22875076
112deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.22465401
113pentose-phosphate shunt (GO:0006098)3.22387279
114electron transport chain (GO:0022900)3.21945079
115negative regulation of erythrocyte differentiation (GO:0045647)3.21888589
116peptidyl-arginine omega-N-methylation (GO:0035247)3.20757305
117regulation of ubiquitin-protein transferase activity (GO:0051438)3.19463274
118mitotic recombination (GO:0006312)3.17703020
119CENP-A containing nucleosome assembly (GO:0034080)3.15352366
120mitochondrial fusion (GO:0008053)3.13482874
121amino acid salvage (GO:0043102)3.12712626
122L-methionine salvage (GO:0071267)3.12712626
123L-methionine biosynthetic process (GO:0071265)3.12712626
124chromatin remodeling at centromere (GO:0031055)3.12648922
125telomere maintenance via telomere lengthening (GO:0010833)3.12216592
126antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.10863918
127NADH dehydrogenase complex assembly (GO:0010257)3.09451769
128regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 3.03152168
129protein localization to endosome (GO:0036010)3.01293987
130pore complex assembly (GO:0046931)3.00593583
131proline metabolic process (GO:0006560)2.99497306
132protein-DNA complex disassembly (GO:0032986)2.99423421
133nucleosome disassembly (GO:0006337)2.99423421
134nuclear pore organization (GO:0006999)2.97032564
135DNA topological change (GO:0006265)2.96091499
136apoptotic process involved in morphogenesis (GO:0060561)2.94579460
137regulation of translational termination (GO:0006449)2.91897064
138N-glycan processing (GO:0006491)2.85470857
139glucose 6-phosphate metabolic process (GO:0051156)2.80633181
140positive regulation of DNA-templated transcription, elongation (GO:0032786)2.78028017
141regulation of nucleobase-containing compound transport (GO:0032239)2.76377550
142L-serine metabolic process (GO:0006563)2.75917603
143positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.73277759
144regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.73277759
145glucose catabolic process (GO:0006007)2.71754733
146folic acid metabolic process (GO:0046655)2.71292329
147protein localization to chromosome, centromeric region (GO:0071459)2.71139252
148RNA stabilization (GO:0043489)2.70706636
149mRNA stabilization (GO:0048255)2.70706636
150regulation of RNA export from nucleus (GO:0046831)2.70667741
151mitotic sister chromatid segregation (GO:0000070)2.68601081
152mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.68302141
153protein export from nucleus (GO:0006611)2.67540704
154NADPH regeneration (GO:0006740)2.67402583
155protoporphyrinogen IX metabolic process (GO:0046501)2.66013872
156histone arginine methylation (GO:0034969)2.65284253
157GDP-mannose metabolic process (GO:0019673)2.63745633
158mRNA catabolic process (GO:0006402)2.61355391
159activation of MAPKKK activity (GO:0000185)2.60378026
160pentose metabolic process (GO:0019321)2.60113603
161negative regulation of RNA splicing (GO:0033119)2.59946973
162negative regulation of organelle assembly (GO:1902116)2.57938046
163modulation by symbiont of host cellular process (GO:0044068)2.57526981
164protein insertion into membrane (GO:0051205)2.57073489
165regulation of chromatin binding (GO:0035561)2.56066124
166RNA catabolic process (GO:0006401)2.55820208
167modulation by virus of host process (GO:0019054)2.51469488
168myeloid cell homeostasis (GO:0002262)2.50589683
169protein complex localization (GO:0031503)2.48734928
170intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.48148673
171atrioventricular valve morphogenesis (GO:0003181)2.48003977

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.07828367
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.48235275
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.19932616
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.06660498
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.86309392
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.83486834
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.80693821
8* ETS1_20019798_ChIP-Seq_JURKAT_Human3.70834669
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.50419206
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.38546347
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.27196454
12MYC_18358816_ChIP-ChIP_MESCs_Mouse3.24062585
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.19659489
14MYC_19079543_ChIP-ChIP_MESCs_Mouse3.11818213
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.09895455
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.96642287
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.75996205
18E2F4_17652178_ChIP-ChIP_JURKAT_Human2.68832179
19XRN2_22483619_ChIP-Seq_HELA_Human2.62698832
20* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.61883991
21MYC_22102868_ChIP-Seq_BL_Human2.55831669
22* VDR_23849224_ChIP-Seq_CD4+_Human2.53970524
23THAP11_20581084_ChIP-Seq_MESCs_Mouse2.49352460
24* VDR_21846776_ChIP-Seq_THP-1_Human2.44434477
25FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.43663457
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.34549460
27YY1_21170310_ChIP-Seq_MESCs_Mouse2.32803942
28ELF1_17652178_ChIP-ChIP_JURKAT_Human2.30181065
29E2F1_18555785_ChIP-Seq_MESCs_Mouse2.29856760
30DCP1A_22483619_ChIP-Seq_HELA_Human2.26988245
31NELFA_20434984_ChIP-Seq_ESCs_Mouse2.19366649
32FOXP3_21729870_ChIP-Seq_TREG_Human2.12232209
33GABP_19822575_ChIP-Seq_HepG2_Human2.11566084
34FOXM1_23109430_ChIP-Seq_U2OS_Human2.09827610
35ZNF263_19887448_ChIP-Seq_K562_Human2.06118388
36TTF2_22483619_ChIP-Seq_HELA_Human2.04736454
37* LXR_22292898_ChIP-Seq_THP-1_Human2.04045173
38MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.00350821
39TP63_17297297_ChIP-ChIP_HaCaT_Human1.94969857
40ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.92316541
41PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.89437172
42SRF_21415370_ChIP-Seq_HL-1_Mouse1.86593541
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.84468434
44MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.78098804
45PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.77842871
46ELK3_25401928_ChIP-Seq_HUVEC_Human1.77677664
47NANOG_18555785_ChIP-Seq_MESCs_Mouse1.72837311
48THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.69899849
49KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.69381978
50NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.68821969
51ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.67252850
52MYCN_18555785_ChIP-Seq_MESCs_Mouse1.64601553
53SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.63184957
54ELK1_19687146_ChIP-ChIP_HELA_Human1.63039913
55RACK7_27058665_Chip-Seq_MCF-7_Human1.61882404
56FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.59302770
57EGR1_19374776_ChIP-ChIP_THP-1_Human1.59036172
58YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.53874320
59TET1_21451524_ChIP-Seq_MESCs_Mouse1.53057621
60RARG_19884340_ChIP-ChIP_MEFs_Mouse1.52314911
61TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.51861463
62NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.49675349
63CIITA_25753668_ChIP-Seq_RAJI_Human1.47347534
64PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46123937
65CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.45029798
66ZFX_18555785_ChIP-Seq_MESCs_Mouse1.44462746
67POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.43670772
68CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.42962383
69HOXB4_20404135_ChIP-ChIP_EML_Mouse1.42226202
70CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.40789358
71FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.40743223
72P68_20966046_ChIP-Seq_HELA_Human1.37913060
73KDM5A_27292631_Chip-Seq_BREAST_Human1.37141212
74KDM2B_26808549_Chip-Seq_DND41_Human1.34906318
75BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.31211226
76ELK1_22589737_ChIP-Seq_MCF10A_Human1.30738783
77MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.30384314
78KDM2B_26808549_Chip-Seq_SUP-B15_Human1.26672496
79KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.25762303
80TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.25342246
81ZFP281_18757296_ChIP-ChIP_E14_Mouse1.24667336
82ESR1_15608294_ChIP-ChIP_MCF-7_Human1.23819797
83POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.23282895
84AR_21909140_ChIP-Seq_LNCAP_Human1.22678341
85E2F1_21310950_ChIP-Seq_MCF-7_Human1.21963405
86UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.21866051
87ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.21631117
88NCOR1_26117541_ChIP-Seq_K562_Human1.21302657
89TCF7_22412390_ChIP-Seq_EML_Mouse1.20757922
90ERG_20887958_ChIP-Seq_HPC-7_Mouse1.19263553
91MAF_26560356_Chip-Seq_TH1_Human1.18179644
92SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.17086458
93CTCF_27219007_Chip-Seq_ERYTHROID_Human1.15820962
94SA1_27219007_Chip-Seq_ERYTHROID_Human1.15275098
95ELF1_20517297_ChIP-Seq_JURKAT_Human1.15145014
96MYC_18940864_ChIP-ChIP_HL60_Human1.14864003
97KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.14799219
98SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.13459719
99MAF_26560356_Chip-Seq_TH2_Human1.13342334
100ATF3_27146783_Chip-Seq_COLON_Human1.13200374
101SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.12424287
102SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.12199339
103EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11961186
104SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.10576092
105TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10324007
106ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.10146084
107KDM2B_26808549_Chip-Seq_K562_Human1.09568543
108DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08613062
109STAT3_1855785_ChIP-Seq_MESCs_Mouse1.08377127
110CLOCK_20551151_ChIP-Seq_293T_Human1.07915058
111SRY_22984422_ChIP-ChIP_TESTIS_Rat1.06664828
112EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.06605943
113PADI4_21655091_ChIP-ChIP_MCF-7_Human1.06470054
114SMC4_20622854_ChIP-Seq_HELA_Human1.06006511
115ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.05794542
116SOX2_18555785_ChIP-Seq_MESCs_Mouse1.05433660
117KLF4_18555785_ChIP-Seq_MESCs_Mouse1.03061478
118KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.02231066
119CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.01744377
120KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.01654732
121TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00920857
122CREB1_26743006_Chip-Seq_LNCaP_Human1.00424120
123ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.99999235
124HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.99881201
125CTCF_18555785_ChIP-Seq_MESCs_Mouse0.98647493
126OCT4_18692474_ChIP-Seq_MEFs_Mouse0.97324502
127SOX2_18692474_ChIP-Seq_MEFs_Mouse0.95163613
128CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.94353360
129HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.92888811
130E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92775895
131YY1_22570637_ChIP-Seq_MALME-3M_Human0.90038106
132FOXP1_21924763_ChIP-Seq_HESCs_Human0.88386496
133SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.87925286
134TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87682668
135TFEB_21752829_ChIP-Seq_HELA_Human0.85436498
136CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.84439461
137CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.81807522
138NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.80849022
139CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.80472655
140EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.79099227
141FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78042828
142SOX17_20123909_ChIP-Seq_XEN_Mouse0.77171272
143DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.76949267
144CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.74452386
145TBX5_21415370_ChIP-Seq_HL-1_Mouse0.74157369
146GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.73246396

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.92562213
2MP0004957_abnormal_blastocyst_morpholog4.76924524
3MP0003111_abnormal_nucleus_morphology4.11407132
4MP0010094_abnormal_chromosome_stability3.74894044
5MP0003077_abnormal_cell_cycle3.62822433
6MP0005058_abnormal_lysosome_morphology3.41063772
7MP0008932_abnormal_embryonic_tissue3.28043503
8MP0008057_abnormal_DNA_replication3.24114238
9MP0003705_abnormal_hypodermis_morpholog3.20165430
10MP0002877_abnormal_melanocyte_morpholog3.18628121
11MP0008058_abnormal_DNA_repair3.13814306
12MP0003806_abnormal_nucleotide_metabolis2.85432656
13MP0004185_abnormal_adipocyte_glucose2.79393980
14MP0009379_abnormal_foot_pigmentation2.69857183
15MP0003718_maternal_effect2.69558757
16MP0001348_abnormal_lacrimal_gland2.49496873
17MP0001529_abnormal_vocalization2.42245958
18MP0004233_abnormal_muscle_weight2.42074728
19MP0003123_paternal_imprinting2.29957682
20MP0003786_premature_aging2.27577836
21MP0008877_abnormal_DNA_methylation2.17592505
22MP0001730_embryonic_growth_arrest2.16523033
23MP0009840_abnormal_foam_cell2.11112746
24MP0006036_abnormal_mitochondrial_physio2.05575248
25MP0008007_abnormal_cellular_replicative2.01296552
26MP0005076_abnormal_cell_differentiation1.98757650
27MP0003186_abnormal_redox_activity1.81586684
28MP0003315_abnormal_perineum_morphology1.80116721
29MP0006035_abnormal_mitochondrial_morpho1.77445165
30MP0000678_abnormal_parathyroid_gland1.75554691
31MP0000350_abnormal_cell_proliferation1.74383991
32MP0009333_abnormal_splenocyte_physiolog1.72436625
33MP0003136_yellow_coat_color1.72067738
34MP0002653_abnormal_ependyma_morphology1.67833509
35MP0005501_abnormal_skin_physiology1.65306592
36MP0005623_abnormal_meninges_morphology1.63517590
37MP0003329_amyloid_beta_deposits1.62257827
38MP0010234_abnormal_vibrissa_follicle1.61519491
39MP0002132_abnormal_respiratory_system1.60149029
40MP0001661_extended_life_span1.57881688
41MP0006292_abnormal_olfactory_placode1.55757069
42MP0001905_abnormal_dopamine_level1.53522601
43MP0003453_abnormal_keratinocyte_physiol1.52531192
44MP0000747_muscle_weakness1.51240193
45MP0003566_abnormal_cell_adhesion1.50633176
46MP0004858_abnormal_nervous_system1.47399866
47MP0005666_abnormal_adipose_tissue1.47027946
48MP0001697_abnormal_embryo_size1.44651503
49MP0004133_heterotaxia1.39923922
50MP0000313_abnormal_cell_death1.38500200
51MP0009672_abnormal_birth_weight1.38227288
52MP0002080_prenatal_lethality1.36994561
53MP0003191_abnormal_cellular_cholesterol1.33081991
54MP0001849_ear_inflammation1.32559258
55MP0003656_abnormal_erythrocyte_physiolo1.32023437
56MP0002210_abnormal_sex_determination1.29892234
57MP0002160_abnormal_reproductive_system1.29605134
58MP0008260_abnormal_autophagy1.29308555
59MP0002089_abnormal_postnatal_growth/wei1.27907002
60MP0005083_abnormal_biliary_tract1.27299412
61MP0008789_abnormal_olfactory_epithelium1.26759678
62MP0000537_abnormal_urethra_morphology1.26312537
63MP0002751_abnormal_autonomic_nervous1.25823762
64MP0002638_abnormal_pupillary_reflex1.25738483
65MP0000490_abnormal_crypts_of1.22716162
66MP0002796_impaired_skin_barrier1.21018665
67MP0001853_heart_inflammation1.20562616
68MP0000358_abnormal_cell_content/1.20402542
69MP0001672_abnormal_embryogenesis/_devel1.19125108
70MP0005380_embryogenesis_phenotype1.19125108
71MP0001986_abnormal_taste_sensitivity1.17753508
72MP0005257_abnormal_intraocular_pressure1.17605038
73MP0004142_abnormal_muscle_tone1.15829778
74MP0002085_abnormal_embryonic_tissue1.15038299
75MP0001145_abnormal_male_reproductive1.13795790
76MP0002019_abnormal_tumor_incidence1.13751939
77MP0005375_adipose_tissue_phenotype1.12677957
78MP0010030_abnormal_orbit_morphology1.08433132
79MP0001727_abnormal_embryo_implantation1.05400584
80MP0000759_abnormal_skeletal_muscle1.03941425
81MP0001929_abnormal_gametogenesis1.03580530
82MP0005389_reproductive_system_phenotype1.00398616
83MP0005408_hypopigmentation0.97428192
84MP0000003_abnormal_adipose_tissue0.96517162
85MP0010307_abnormal_tumor_latency0.96471463
86MP0009053_abnormal_anal_canal0.96087063
87MP0003984_embryonic_growth_retardation0.95189144
88MP0004947_skin_inflammation0.94992402
89MP0003115_abnormal_respiratory_system0.94332020
90MP0000653_abnormal_sex_gland0.93490562
91MP0004147_increased_porphyrin_level0.93437464
92MP0002088_abnormal_embryonic_growth/wei0.90737118
93MP0003436_decreased_susceptibility_to0.89750734
94MP0002163_abnormal_gland_morphology0.88924987
95MP0003646_muscle_fatigue0.87906655
96MP0005075_abnormal_melanosome_morpholog0.87201788
97MP0001764_abnormal_homeostasis0.85863005
98MP0005621_abnormal_cell_physiology0.85691325
99MP0005266_abnormal_metabolism0.85129868
100MP0005499_abnormal_olfactory_system0.84194655
101MP0005394_taste/olfaction_phenotype0.84194655
102MP0009931_abnormal_skin_appearance0.83872835
103MP0003879_abnormal_hair_cell0.83846520
104MP0003942_abnormal_urinary_system0.83617831
105MP0004381_abnormal_hair_follicle0.83412291
106MP0002092_abnormal_eye_morphology0.81494439
107MP0003567_abnormal_fetal_cardiomyocyte0.80353061
108MP0002084_abnormal_developmental_patter0.79311596
109MP0002396_abnormal_hematopoietic_system0.79065422
110MP0001919_abnormal_reproductive_system0.77977103
111MP0003303_peritoneal_inflammation0.76270867
112MP0001293_anophthalmia0.75765658
113MP0003698_abnormal_male_reproductive0.75043369
114MP0003119_abnormal_digestive_system0.74313997
115MP0001216_abnormal_epidermal_layer0.74085881
116MP0005193_abnormal_anterior_eye0.73892326
117MP0004087_abnormal_muscle_fiber0.73851038
118MP0002269_muscular_atrophy0.73814666
119MP0003172_abnormal_lysosome_physiology0.73391503
120MP0000733_abnormal_muscle_development0.72974485
121MP0001881_abnormal_mammary_gland0.72737506
122MP0006276_abnormal_autonomic_nervous0.72634719
123MP0000609_abnormal_liver_physiology0.72110680
124MP0006072_abnormal_retinal_apoptosis0.71406299
125MP0000604_amyloidosis0.70972495
126MP0002938_white_spotting0.70698762
127MP0000703_abnormal_thymus_morphology0.69727965
128MP0001346_abnormal_lacrimal_gland0.69671509
129MP0009278_abnormal_bone_marrow0.68586217
130MP0004808_abnormal_hematopoietic_stem0.67080320
131MP0002697_abnormal_eye_size0.65408233
132MP0004264_abnormal_extraembryonic_tissu0.65372021
133MP0002722_abnormal_immune_system0.65280953
134MP0003221_abnormal_cardiomyocyte_apopto0.63851259
135MP0003763_abnormal_thymus_physiology0.63768487
136MP0004145_abnormal_muscle_electrophysio0.62810798
137MP0003938_abnormal_ear_development0.62689128
138MP0002102_abnormal_ear_morphology0.62435637
139MP0000750_abnormal_muscle_regeneration0.62171720
140MP0005451_abnormal_body_composition0.61891722
141MP0005397_hematopoietic_system_phenotyp0.61306998
142MP0001545_abnormal_hematopoietic_system0.61306998
143MP0001542_abnormal_bone_strength0.61095458
144MP0003121_genomic_imprinting0.60899002
145MP0000858_altered_metastatic_potential0.60838937
146MP0002736_abnormal_nociception_after0.60428078
147MP0000689_abnormal_spleen_morphology0.59966565
148MP0000049_abnormal_middle_ear0.59106641
149MP0002398_abnormal_bone_marrow0.58240016
150MP0005384_cellular_phenotype0.57693328
151MP0001485_abnormal_pinna_reflex0.57034962
152MP0002086_abnormal_extraembryonic_tissu0.56407897
153MP0002161_abnormal_fertility/fecundity0.56374357
154MP0002429_abnormal_blood_cell0.54800434
155MP0004197_abnormal_fetal_growth/weight/0.53756046
156MP0008872_abnormal_physiological_respon0.53437718
157MP0003941_abnormal_skin_development0.53152540

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.74986288
2Achilles tendon contracture (HP:0001771)5.45126632
3Abnormal number of erythroid precursors (HP:0012131)5.39436842
4Abnormality of the Achilles tendon (HP:0005109)4.96415175
5Acute necrotizing encephalopathy (HP:0006965)4.92300255
6Cerebral hypomyelination (HP:0006808)4.76735252
7Mitochondrial inheritance (HP:0001427)4.58694415
8Hepatocellular necrosis (HP:0001404)4.44349248
9Abnormal mitochondria in muscle tissue (HP:0008316)4.43226450
10Reticulocytopenia (HP:0001896)4.43091732
11Increased CSF lactate (HP:0002490)4.10944579
12Deep palmar crease (HP:0006191)4.09001500
13Breast hypoplasia (HP:0003187)4.08498317
14Macrocytic anemia (HP:0001972)4.02481643
15Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.98666531
16Acute encephalopathy (HP:0006846)3.94633675
17Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.83558274
18Decreased activity of mitochondrial respiratory chain (HP:0008972)3.83558274
19Progressive macrocephaly (HP:0004481)3.82744950
20Birth length less than 3rd percentile (HP:0003561)3.82566463
21Hepatic necrosis (HP:0002605)3.80775389
22Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.61278778
23Increased hepatocellular lipid droplets (HP:0006565)3.59097932
24Increased serum lactate (HP:0002151)3.57661281
25Carpal bone hypoplasia (HP:0001498)3.49088650
26Long palpebral fissure (HP:0000637)3.45722588
27Rough bone trabeculation (HP:0100670)3.40572556
28Pallor (HP:0000980)3.38137228
293-Methylglutaconic aciduria (HP:0003535)3.36761654
30Abnormality of glycolysis (HP:0004366)3.29906253
31Increased serum pyruvate (HP:0003542)3.29906253
32Oral leukoplakia (HP:0002745)3.27468289
33Hyperacusis (HP:0010780)3.22277140
34Lipid accumulation in hepatocytes (HP:0006561)3.10731413
35Insomnia (HP:0100785)3.10120848
36Abnormal gallbladder physiology (HP:0012438)3.06960575
37Cholecystitis (HP:0001082)3.06960575
38Respiratory failure (HP:0002878)3.06527667
39Aplasia/Hypoplasia of the sacrum (HP:0008517)2.99999128
40Lactic acidosis (HP:0003128)2.91299600
41Progressive muscle weakness (HP:0003323)2.89020039
42Exercise intolerance (HP:0003546)2.85266873
43CNS hypomyelination (HP:0003429)2.85098006
44Reticulocytosis (HP:0001923)2.80594136
45Leukodystrophy (HP:0002415)2.79447524
46Vertebral compression fractures (HP:0002953)2.77342611
47Aplasia/Hypoplasia of the patella (HP:0006498)2.75968803
48Patellar aplasia (HP:0006443)2.74620033
49Emotional lability (HP:0000712)2.73648981
50Cerebral edema (HP:0002181)2.73514341
51Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.71052426
52Increased intramyocellular lipid droplets (HP:0012240)2.69368366
53Ragged-red muscle fibers (HP:0003200)2.68912065
54Microvesicular hepatic steatosis (HP:0001414)2.66899432
55Pointed chin (HP:0000307)2.66653841
56CNS demyelination (HP:0007305)2.65769626
57Abnormality of the anterior horn cell (HP:0006802)2.64872170
58Degeneration of anterior horn cells (HP:0002398)2.64872170
59Renal Fanconi syndrome (HP:0001994)2.63765187
60Multiple enchondromatosis (HP:0005701)2.55715747
61Exertional dyspnea (HP:0002875)2.54952382
62Progressive external ophthalmoplegia (HP:0000590)2.48293966
63Abnormal trabecular bone morphology (HP:0100671)2.48218772
64Abnormality of the tricuspid valve (HP:0001702)2.47520659
65Secondary amenorrhea (HP:0000869)2.45610782
66Microretrognathia (HP:0000308)2.42283073
67Trismus (HP:0000211)2.42144659
68Obstructive sleep apnea (HP:0002870)2.42143991
69Aplastic anemia (HP:0001915)2.41689448
70Horseshoe kidney (HP:0000085)2.41092734
71Squamous cell carcinoma (HP:0002860)2.38331792
72Abnormality of the thoracic spine (HP:0100711)2.33352653
73Proximal placement of thumb (HP:0009623)2.32192770
74Deviation of the thumb (HP:0009603)2.31987907
75Premature graying of hair (HP:0002216)2.31250551
76Hyperthyroidism (HP:0000836)2.30540392
77Absent thumb (HP:0009777)2.30537634
78Optic disc pallor (HP:0000543)2.30371765
79Renal duplication (HP:0000075)2.28250416
80Respiratory difficulties (HP:0002880)2.25381329
81Thoracic kyphosis (HP:0002942)2.23943539
82Centrally nucleated skeletal muscle fibers (HP:0003687)2.23723058
83Premature ovarian failure (HP:0008209)2.22947956
84Delusions (HP:0000746)2.22389406
85Absent radius (HP:0003974)2.22097272
86Myopathic facies (HP:0002058)2.21675398
87Distal lower limb amyotrophy (HP:0008944)2.20435305
88Truncus arteriosus (HP:0001660)2.18315679
89Increased muscle lipid content (HP:0009058)2.15577410
90Disproportionate tall stature (HP:0001519)2.14093195
91Overriding aorta (HP:0002623)2.13572694
92Hyperparathyroidism (HP:0000843)2.11386028
93Type I transferrin isoform profile (HP:0003642)2.11360519
94Hypertensive crisis (HP:0100735)2.10804026
95Cellular immunodeficiency (HP:0005374)2.10616894
96Irregular epiphyses (HP:0010582)2.09433885
9711 pairs of ribs (HP:0000878)2.09409941
98Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.08686187
99Abnormality of the heme biosynthetic pathway (HP:0010472)2.07604425
100Aplasia involving forearm bones (HP:0009822)2.07448812
101Absent forearm bone (HP:0003953)2.07448812
102Abnormality of the preputium (HP:0100587)2.05825235
103Impulsivity (HP:0100710)2.02950456
104Pancytopenia (HP:0001876)2.02789919
105Poor head control (HP:0002421)2.02557706
106Sparse eyelashes (HP:0000653)2.00684737
107Increased connective tissue (HP:0009025)1.99249549
108Hypoplasia of the capital femoral epiphysis (HP:0003090)1.98858576
109Cleft eyelid (HP:0000625)1.98278730
110Entropion (HP:0000621)1.98269323
111Meckel diverticulum (HP:0002245)1.97828253
112Abnormality of the ileum (HP:0001549)1.96676832
113Concave nail (HP:0001598)1.96317400
114Triphalangeal thumb (HP:0001199)1.95833142
115Gastrointestinal stroma tumor (HP:0100723)1.95550700
116Poikiloderma (HP:0001029)1.95465492
117Missing ribs (HP:0000921)1.94946553
118Upper limb amyotrophy (HP:0009129)1.94469504
119Distal upper limb amyotrophy (HP:0007149)1.94469504
120Ulnar bowing (HP:0003031)1.94385808
121Abnormality of the calcaneus (HP:0008364)1.93274849
122Aplasia/Hypoplasia involving the musculature (HP:0001460)1.92457616
123Hypoparathyroidism (HP:0000829)1.91154784
124Orthostatic hypotension (HP:0001278)1.89989109
125Colon cancer (HP:0003003)1.89888964
126Abnormality of the labia minora (HP:0012880)1.89298139
127External ophthalmoplegia (HP:0000544)1.88859501
128Deep venous thrombosis (HP:0002625)1.88490512
129Selective tooth agenesis (HP:0001592)1.87628899
130Elfin facies (HP:0004428)1.87523795
131Hypoplasia of the radius (HP:0002984)1.87464748
132Cholelithiasis (HP:0001081)1.86545505
133Abnormal number of incisors (HP:0011064)1.85707014
134Unsteady gait (HP:0002317)1.85262716
135Pseudobulbar signs (HP:0002200)1.85213493
136Glossoptosis (HP:0000162)1.84787305
137Neoplasm of the pancreas (HP:0002894)1.84301491
138Aplasia/hypoplasia of the uterus (HP:0008684)1.83878027
139Generalized hyperpigmentation (HP:0007440)1.83861876
140Postnatal microcephaly (HP:0005484)1.81672160
141Ankyloglossia (HP:0010296)1.81652562
142Broad distal phalanx of finger (HP:0009836)1.81557123
143Cerebral inclusion bodies (HP:0100314)1.81171677
144Stenosis of the external auditory canal (HP:0000402)1.81057929
145Bone marrow hypocellularity (HP:0005528)1.79746676
146Abnormality of the distal phalanges of the toes (HP:0010182)1.79501679
147Lethargy (HP:0001254)1.79163486
148Sparse lateral eyebrow (HP:0005338)1.78247084
149Dysmetric saccades (HP:0000641)1.77784255
150Abnormality of reticulocytes (HP:0004312)1.76178016
151Elbow flexion contracture (HP:0002987)1.73006136
152Patellar dislocation (HP:0002999)1.71581115
153Hypercalcemia (HP:0003072)1.70837746
154Limb hypertonia (HP:0002509)1.70802710
155Redundant skin (HP:0001582)1.69807210
156Megaloblastic anemia (HP:0001889)1.68654420
157Hand muscle atrophy (HP:0009130)1.68322444
158Vertebral arch anomaly (HP:0008438)1.68173265
159Abnormality of the umbilical cord (HP:0010881)1.67889272
160Distal lower limb muscle weakness (HP:0009053)1.67649318
161Hypercortisolism (HP:0001578)1.67614270
162Muscle fiber atrophy (HP:0100295)1.67207089
163Dysphonia (HP:0001618)1.65786448
164Asymmetry of the thorax (HP:0001555)1.64776498
165Calcaneovalgus deformity (HP:0001848)1.64519335
166Rhabdomyolysis (HP:0003201)1.64028286
167Foot dorsiflexor weakness (HP:0009027)1.62529107
168Multiple lipomas (HP:0001012)1.61348892
169Premature rupture of membranes (HP:0001788)1.59173403
170Athetosis (HP:0002305)1.57839314
171Abnormal large intestine physiology (HP:0012700)1.57347612
172Bowel incontinence (HP:0002607)1.56720978
173Abnormality of the gallbladder (HP:0005264)1.56695743
174Back pain (HP:0003418)1.56657181
175Peripheral hypomyelination (HP:0007182)1.56218432
176Rib fusion (HP:0000902)1.55299739
177Fragile nails (HP:0001808)1.55255276
178Arnold-Chiari malformation (HP:0002308)1.54866388
179Thrombocytosis (HP:0001894)1.54369990
180Cellulitis (HP:0100658)1.52872750
181Atelectasis (HP:0100750)1.52705144
182Seborrheic dermatitis (HP:0001051)1.52664496

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.40839199
2TRIB34.11620412
3STK163.90879590
4WEE13.72309352
5TLK13.68376288
6EIF2AK13.66990741
7NME23.55067836
8SMG13.29379358
9ICK3.24237557
10SRPK12.90323950
11TESK22.88000356
12EEF2K2.75081121
13PRPF4B2.54812321
14TSSK62.51459969
15VRK12.43603906
16CDC72.36592214
17PLK42.28021734
18ERN12.08123092
19NME12.05893311
20EIF2AK31.82624724
21CDK121.80730141
22SIK11.77984145
23PIM21.73856241
24PLK11.59527079
25MKNK11.46918253
26PNCK1.45525817
27AURKA1.43361953
28MAP3K91.43165298
29ACVR1B1.41398393
30NEK11.40947356
31BRAF1.40734569
32KSR21.34662107
33BRSK21.34655679
34TAOK21.33579292
35ARAF1.33234883
36TTK1.32039661
37LIMK11.28296914
38CDK191.28092996
39NEK21.27716096
40LATS21.26839557
41DYRK31.22336787
42CDK71.22074659
43TESK11.21687905
44PLK31.20938612
45MKNK21.19713934
46FGFR41.19697524
47AURKB1.19504507
48PBK1.18261634
49MAP3K111.13895713
50BRSK11.12617537
51RPS6KB21.09638209
52RIPK41.08792658
53RIPK11.08231051
54MAP3K101.07762523
55KDR1.05672937
56EPHA21.05508844
57DYRK20.99938180
58BCKDK0.98325020
59PKN20.97756279
60MTOR0.95750804
61VRK20.92121467
62TTN0.91988211
63ATR0.91652723
64CHEK20.91171944
65PDK20.89450781
66PAK10.89386222
67ALK0.88410585
68NTRK10.87086587
69CSNK2A20.85900863
70MAP3K130.85643943
71BLK0.84933164
72SIK20.84808132
73ZAK0.84070224
74CCNB10.83286293
75CSNK2A10.82473933
76DAPK30.81341280
77MARK20.78555238
78ILK0.76690310
79AKT30.76344199
80MAP2K30.75431719
81PDPK10.73584621
82RPS6KA50.71796896
83MAP3K80.71621526
84MAP3K10.71475389
85CHEK10.71093991
86AKT20.69472926
87PRKCI0.69187726
88MAPKAPK50.66858910
89MST40.66792946
90RAF10.65255225
91CASK0.64896251
92RPS6KA40.64206629
93DMPK0.63996061
94CAMK1D0.63315627
95ABL20.62490881
96MAP2K70.62066215
97PRKD30.60769332
98PAK40.60315824
99UHMK10.60307499
100PDGFRA0.57894732
101IRAK40.57429319
102CSNK1G30.57083881
103BMX0.57069547
104PTK20.56097298
105MAPK110.54834485
106MAP3K120.54477629
107EIF2AK20.53099738
108CDK20.53030720
109CDK11A0.52365355
110STK40.51727507
111MOS0.51373855
112CDK140.51067791
113RPS6KA20.50845009
114TYRO30.50538602
115PASK0.49980061
116PTK60.48256886
117CDK40.48191634
118CLK10.48173999
119RPS6KL10.48138140
120RPS6KC10.48138140
121CSNK1E0.47140781
122CDK180.46142450
123CDK150.45913709
124MAP3K60.45798035
125IRAK30.45634748
126BCR0.42919244
127PIM10.42097949
128GRK60.41964110
129MST1R0.41334702
130IRAK20.40070109
131CDK80.38682737
132DAPK10.38383586
133CAMKK10.37080954
134CAMK2B0.36771016
135CDK10.36527429
136GRK50.33128880
137ATM0.31093865
138PINK10.30656193
139MAP2K20.29151017
140MAPKAPK30.29061824
141WNK30.28551060
142LRRK20.27760663
143CAMK2G0.26668020
144OXSR10.25712086
145GRK70.24191821
146MAP4K10.23386041
147STK390.22806371
148SCYL20.21488924
149MYLK0.21050751
150YES10.19455065

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.05069666
2Proteasome_Homo sapiens_hsa030504.67711303
3RNA polymerase_Homo sapiens_hsa030204.22740084
4DNA replication_Homo sapiens_hsa030303.90518989
5Oxidative phosphorylation_Homo sapiens_hsa001903.29247183
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.27923660
7Mismatch repair_Homo sapiens_hsa034303.27197974
8Spliceosome_Homo sapiens_hsa030403.18621196
9Parkinsons disease_Homo sapiens_hsa050123.03978535
10Pyrimidine metabolism_Homo sapiens_hsa002402.69610099
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.51912591
12Homologous recombination_Homo sapiens_hsa034402.47583904
13Nucleotide excision repair_Homo sapiens_hsa034202.45215289
14RNA transport_Homo sapiens_hsa030132.44936572
15Huntingtons disease_Homo sapiens_hsa050162.37506345
16Base excision repair_Homo sapiens_hsa034102.33013149
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.08172557
18Alzheimers disease_Homo sapiens_hsa050101.91646941
19Chronic myeloid leukemia_Homo sapiens_hsa052201.85530543
20Protein export_Homo sapiens_hsa030601.82562580
21Central carbon metabolism in cancer_Homo sapiens_hsa052301.82101421
22Basal transcription factors_Homo sapiens_hsa030221.80478585
23Non-small cell lung cancer_Homo sapiens_hsa052231.80439048
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.79559840
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.73199721
26One carbon pool by folate_Homo sapiens_hsa006701.59539237
27Fanconi anemia pathway_Homo sapiens_hsa034601.59418783
28VEGF signaling pathway_Homo sapiens_hsa043701.56648031
29Acute myeloid leukemia_Homo sapiens_hsa052211.56562807
30Cell cycle_Homo sapiens_hsa041101.56560504
31Sulfur relay system_Homo sapiens_hsa041221.51685173
32Prion diseases_Homo sapiens_hsa050201.50381984
33Purine metabolism_Homo sapiens_hsa002301.49913010
34RNA degradation_Homo sapiens_hsa030181.48049032
35B cell receptor signaling pathway_Homo sapiens_hsa046621.39687026
36Folate biosynthesis_Homo sapiens_hsa007901.37676395
37Pancreatic cancer_Homo sapiens_hsa052121.35451045
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.35329428
39Endometrial cancer_Homo sapiens_hsa052131.28938944
40Other glycan degradation_Homo sapiens_hsa005111.22976856
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.22675359
42Vitamin B6 metabolism_Homo sapiens_hsa007501.21953779
43Renal cell carcinoma_Homo sapiens_hsa052111.20646313
44Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.20636799
45Non-homologous end-joining_Homo sapiens_hsa034501.14167943
46mRNA surveillance pathway_Homo sapiens_hsa030151.03180347
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.02720677
48ErbB signaling pathway_Homo sapiens_hsa040121.02237227
49Glioma_Homo sapiens_hsa052140.99825630
50Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.99350259
51Apoptosis_Homo sapiens_hsa042100.99008967
52Epstein-Barr virus infection_Homo sapiens_hsa051690.98199055
53Cardiac muscle contraction_Homo sapiens_hsa042600.97980229
54Pentose phosphate pathway_Homo sapiens_hsa000300.94009353
55Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.93122405
56Insulin signaling pathway_Homo sapiens_hsa049100.93078181
57Neurotrophin signaling pathway_Homo sapiens_hsa047220.92839763
58Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.92514539
59Notch signaling pathway_Homo sapiens_hsa043300.91456344
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.90395880
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.90197227
62Systemic lupus erythematosus_Homo sapiens_hsa053220.88868286
63Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.87882391
64Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.84430237
65Biosynthesis of amino acids_Homo sapiens_hsa012300.81598400
66Hepatitis B_Homo sapiens_hsa051610.79798987
67Glutathione metabolism_Homo sapiens_hsa004800.77755923
68Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.77300583
69Cyanoamino acid metabolism_Homo sapiens_hsa004600.77112300
70p53 signaling pathway_Homo sapiens_hsa041150.75749001
71Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.73772402
72Colorectal cancer_Homo sapiens_hsa052100.73340125
73Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.70632636
74Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.69502709
75Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68702249
76Metabolic pathways_Homo sapiens_hsa011000.68021492
77Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.67846784
78Carbon metabolism_Homo sapiens_hsa012000.67373532
79Prolactin signaling pathway_Homo sapiens_hsa049170.66879006
80HIF-1 signaling pathway_Homo sapiens_hsa040660.66328013
81Arginine biosynthesis_Homo sapiens_hsa002200.65956983
82Drug metabolism - other enzymes_Homo sapiens_hsa009830.64901184
83Hepatitis C_Homo sapiens_hsa051600.60587507
84Oocyte meiosis_Homo sapiens_hsa041140.58149230
85Regulation of autophagy_Homo sapiens_hsa041400.56969533
86Toll-like receptor signaling pathway_Homo sapiens_hsa046200.56334457
87AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.56191254
88Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54900219
89mTOR signaling pathway_Homo sapiens_hsa041500.54153352
90MicroRNAs in cancer_Homo sapiens_hsa052060.53256944
91Prostate cancer_Homo sapiens_hsa052150.51382453
92Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51076114
932-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.50737442
94Small cell lung cancer_Homo sapiens_hsa052220.50502547
95Endocytosis_Homo sapiens_hsa041440.50346104
96Pyruvate metabolism_Homo sapiens_hsa006200.48720360
97Fructose and mannose metabolism_Homo sapiens_hsa000510.45359774
98Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.45024134
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44723663
100Synaptic vesicle cycle_Homo sapiens_hsa047210.44595674
101Fatty acid elongation_Homo sapiens_hsa000620.44536530
102Arachidonic acid metabolism_Homo sapiens_hsa005900.43770178
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.43165524
104Collecting duct acid secretion_Homo sapiens_hsa049660.40977618
105Linoleic acid metabolism_Homo sapiens_hsa005910.40678895
106Melanoma_Homo sapiens_hsa052180.40610979
107AMPK signaling pathway_Homo sapiens_hsa041520.40541791
108Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40466695
109Arginine and proline metabolism_Homo sapiens_hsa003300.38696784
110Proteoglycans in cancer_Homo sapiens_hsa052050.37277832
111GnRH signaling pathway_Homo sapiens_hsa049120.37190838
112Alcoholism_Homo sapiens_hsa050340.36599896
113Antigen processing and presentation_Homo sapiens_hsa046120.32915764
114Viral carcinogenesis_Homo sapiens_hsa052030.31839271
115Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.31574390
116Primary immunodeficiency_Homo sapiens_hsa053400.31534217
117Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31482845
118Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.30673409
119Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.25726330
120Herpes simplex infection_Homo sapiens_hsa051680.23573137
121SNARE interactions in vesicular transport_Homo sapiens_hsa041300.23164324
122Vibrio cholerae infection_Homo sapiens_hsa051100.20823164
123Phototransduction_Homo sapiens_hsa047440.18677182
124Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.18669819
125Selenocompound metabolism_Homo sapiens_hsa004500.17627631
126Steroid biosynthesis_Homo sapiens_hsa001000.17388716
127alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.16938675
128Thyroid cancer_Homo sapiens_hsa052160.15706916
129N-Glycan biosynthesis_Homo sapiens_hsa005100.15155493
130Phenylalanine metabolism_Homo sapiens_hsa003600.14497217
131Ether lipid metabolism_Homo sapiens_hsa005650.13787521
132Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.13368433
133Asthma_Homo sapiens_hsa053100.12366309
134Allograft rejection_Homo sapiens_hsa053300.11811436
135Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.11348073
136Tyrosine metabolism_Homo sapiens_hsa003500.11308876
137Galactose metabolism_Homo sapiens_hsa000520.10683583
138Legionellosis_Homo sapiens_hsa051340.07286403
139HTLV-I infection_Homo sapiens_hsa051660.06587064
140Graft-versus-host disease_Homo sapiens_hsa053320.05620883
141Sphingolipid metabolism_Homo sapiens_hsa006000.00888395
142Sulfur metabolism_Homo sapiens_hsa009200.00119446
143Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250-0.0675781
144Shigellosis_Homo sapiens_hsa05131-0.0441513
145Peroxisome_Homo sapiens_hsa04146-0.0375930
146Bladder cancer_Homo sapiens_hsa05219-0.0317133
147Glycerophospholipid metabolism_Homo sapiens_hsa00564-0.0290274
148Autoimmune thyroid disease_Homo sapiens_hsa05320-0.0062265

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