PFDN5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the prefoldin alpha subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. The encoded protein may also repress the transcriptional activity of the proto-oncogene c-Myc. Alternatively spliced transcript variants encoding different isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)8.95873800
2translational termination (GO:0006415)8.44521927
3ribosomal small subunit biogenesis (GO:0042274)8.41183402
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.90187143
5energy coupled proton transport, down electrochemical gradient (GO:0015985)7.55237950
6ATP synthesis coupled proton transport (GO:0015986)7.55237950
7cotranslational protein targeting to membrane (GO:0006613)7.44303174
8SRP-dependent cotranslational protein targeting to membrane (GO:0006614)7.40647009
9protein targeting to ER (GO:0045047)7.36485701
10establishment of protein localization to endoplasmic reticulum (GO:0072599)7.04656076
11protein localization to endoplasmic reticulum (GO:0070972)6.93565023
12ribosomal small subunit assembly (GO:0000028)6.92955389
13mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.85882168
14translational elongation (GO:0006414)6.80199456
15viral life cycle (GO:0019058)6.65299930
16cellular protein complex disassembly (GO:0043624)6.61424419
17respiratory electron transport chain (GO:0022904)6.07238671
18nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.99950594
19electron transport chain (GO:0022900)5.94006471
20translational initiation (GO:0006413)5.58752338
21protein complex disassembly (GO:0043241)5.48992756
22protein neddylation (GO:0045116)5.37026516
23maturation of SSU-rRNA (GO:0030490)5.22984903
24macromolecular complex disassembly (GO:0032984)5.14067467
25establishment of protein localization to mitochondrial membrane (GO:0090151)5.12410948
26ribosomal large subunit biogenesis (GO:0042273)4.99973948
27protein targeting to membrane (GO:0006612)4.98433415
28GTP biosynthetic process (GO:0006183)4.39353678
29chaperone-mediated protein transport (GO:0072321)4.21491719
30translation (GO:0006412)4.19767426
31hydrogen ion transmembrane transport (GO:1902600)3.90499254
32nuclear-transcribed mRNA catabolic process (GO:0000956)3.85092589
33protein complex biogenesis (GO:0070271)3.80697251
34purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.76694730
35platelet dense granule organization (GO:0060155)3.67253004
36mRNA catabolic process (GO:0006402)3.62640382
37purine nucleoside triphosphate biosynthetic process (GO:0009145)3.60290793
38ATP biosynthetic process (GO:0006754)3.58792173
39establishment of protein localization to membrane (GO:0090150)3.58070226
40UTP biosynthetic process (GO:0006228)3.53000786
41proton transport (GO:0015992)3.42076041
42protein targeting (GO:0006605)3.40361715
43mitochondrial respiratory chain complex I assembly (GO:0032981)3.40180388
44NADH dehydrogenase complex assembly (GO:0010257)3.40180388
45mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.40180388
46hydrogen transport (GO:0006818)3.32903933
47mitochondrial respiratory chain complex assembly (GO:0033108)3.31571076
48ribonucleoside triphosphate biosynthetic process (GO:0009201)3.19748046
49response to interferon-beta (GO:0035456)3.19617323
50cellular response to interferon-beta (GO:0035458)3.10392025
51RNA catabolic process (GO:0006401)3.09032545
52protein localization to membrane (GO:0072657)2.99813645
53establishment of protein localization to organelle (GO:0072594)2.94473524
54UTP metabolic process (GO:0046051)2.93207678
55central nervous system myelination (GO:0022010)2.89389110
56axon ensheathment in central nervous system (GO:0032291)2.89389110
57tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.86599152
58RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.86599152
59keratinocyte development (GO:0003334)2.86003867
60epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.85056450
61guanosine-containing compound biosynthetic process (GO:1901070)2.84790371
62positive regulation of respiratory burst (GO:0060267)2.83030357
63CTP biosynthetic process (GO:0006241)2.81443171
64CTP metabolic process (GO:0046036)2.81443171
65cilium movement (GO:0003341)2.80311829
66transcription elongation from RNA polymerase III promoter (GO:0006385)2.75322081
67termination of RNA polymerase III transcription (GO:0006386)2.75322081
68inner mitochondrial membrane organization (GO:0007007)2.73405904
69epithelial cilium movement (GO:0003351)2.73019122
70regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.71652992
71DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.69189222
72cytidine metabolic process (GO:0046087)2.68010989
73cytidine catabolic process (GO:0006216)2.68010989
74cytidine deamination (GO:0009972)2.68010989
75protein targeting to mitochondrion (GO:0006626)2.67563151
76purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.66557005
77nucleoside diphosphate phosphorylation (GO:0006165)2.64920131
78regulation of cellular amino acid metabolic process (GO:0006521)2.64467446
79ribonucleoprotein complex biogenesis (GO:0022613)2.64232387
80negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.63183514
81cellular component biogenesis (GO:0044085)2.62970426
82establishment of protein localization to mitochondrion (GO:0072655)2.56546178
83nucleoside triphosphate biosynthetic process (GO:0009142)2.56452744
84proteasome assembly (GO:0043248)2.56288004
85signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.54985702
86signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.54985702
87signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.54985702
88antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.54395332
89signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.54006109
90intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.54006109
91oxidative phosphorylation (GO:0006119)2.51254676
92purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.45169468
93purine nucleoside monophosphate biosynthetic process (GO:0009127)2.45169468
94regulation of oxidative phosphorylation (GO:0002082)2.43811724
95respiratory chain complex IV assembly (GO:0008535)2.42926758
96dopamine biosynthetic process (GO:0042416)2.41919077
97axonemal dynein complex assembly (GO:0070286)2.41470077
98axoneme assembly (GO:0035082)2.41355501
99positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.41311300
100intracellular protein transmembrane import (GO:0044743)2.40536209
101deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.39440476
102protein localization to mitochondrion (GO:0070585)2.36964029
103pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.35855800
104negative regulation of response to food (GO:0032096)2.34458736
105negative regulation of appetite (GO:0032099)2.34458736
106regulation of catecholamine metabolic process (GO:0042069)2.34047521
107regulation of dopamine metabolic process (GO:0042053)2.34047521
108mitochondrial transport (GO:0006839)2.32319369
109DNA deamination (GO:0045006)2.31457054
110negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.30811755
111cytochrome complex assembly (GO:0017004)2.30699548
112negative regulation of heart rate (GO:0010459)2.29329383
113pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.28645084
114ATP hydrolysis coupled proton transport (GO:0015991)2.27324996
115energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.27324996
116GPI anchor biosynthetic process (GO:0006506)2.24726592
117regulation of mitochondrial translation (GO:0070129)2.17519766
118regulation of cilium movement (GO:0003352)2.16491085
119dopamine transport (GO:0015872)2.15891830
120calcium-mediated signaling using intracellular calcium source (GO:0035584)2.15444019
121cullin deneddylation (GO:0010388)2.15157719
122regulation of protein kinase A signaling (GO:0010738)2.13897141
123sequestering of actin monomers (GO:0042989)2.12960695
124antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.09206885
125viral protein processing (GO:0019082)2.07851852

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat6.64699558
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.26438135
3EZH2_22144423_ChIP-Seq_EOC_Human3.78558104
4ELF1_17652178_ChIP-ChIP_JURKAT_Human3.38783896
5BMI1_23680149_ChIP-Seq_NPCS_Mouse2.91882859
6IRF8_22096565_ChIP-ChIP_GC-B_Human2.70283531
7* GABP_17652178_ChIP-ChIP_JURKAT_Human2.60617522
8VDR_22108803_ChIP-Seq_LS180_Human2.54280769
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.46341023
10CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.20762803
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.18623545
12CBX2_27304074_Chip-Seq_ESCs_Mouse2.18527702
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.12974644
14FOXP3_21729870_ChIP-Seq_TREG_Human2.10703653
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.09769561
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.08642649
17* EST1_17652178_ChIP-ChIP_JURKAT_Human2.05770352
18* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.00059999
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.96799985
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.96034219
21JARID2_20075857_ChIP-Seq_MESCs_Mouse1.86899408
22IKZF1_21737484_ChIP-ChIP_HCT116_Human1.86729499
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.86274090
24KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.84872382
25EED_16625203_ChIP-ChIP_MESCs_Mouse1.81542979
26* ETS1_20019798_ChIP-Seq_JURKAT_Human1.78852190
27SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.77967728
28CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.77597660
29ELK1_22589737_ChIP-Seq_MCF10A_Human1.77189341
30SUZ12_27294783_Chip-Seq_ESCs_Mouse1.77067704
31SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.76626212
32SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.76529218
33PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.73810384
34* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.72225405
35SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.71989672
36IRF8_21731497_ChIP-ChIP_J774_Mouse1.71330571
37SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.71054850
38BP1_19119308_ChIP-ChIP_Hs578T_Human1.70640094
39TAF15_26573619_Chip-Seq_HEK293_Human1.67052567
40HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.64001082
41* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.62971669
42STAT6_21828071_ChIP-Seq_BEAS2B_Human1.62154053
43RNF2_27304074_Chip-Seq_NSC_Mouse1.56565185
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.54718023
45CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.52098657
46* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.50605346
47IRF1_19129219_ChIP-ChIP_H3396_Human1.49801311
48EZH2_27294783_Chip-Seq_ESCs_Mouse1.45133966
49TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.44492396
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.43484221
51ZNF274_21170338_ChIP-Seq_K562_Hela1.41080096
52ELK1_19687146_ChIP-ChIP_HELA_Human1.37396279
53* TTF2_22483619_ChIP-Seq_HELA_Human1.36962905
54ERG_21242973_ChIP-ChIP_JURKAT_Human1.35587457
55RNF2_18974828_ChIP-Seq_MESCs_Mouse1.34398659
56EZH2_18974828_ChIP-Seq_MESCs_Mouse1.34398659
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.33969903
58STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.33815178
59MTF2_20144788_ChIP-Seq_MESCs_Mouse1.29721232
60STAT1_20625510_ChIP-Seq_HELA_Human1.29370477
61TP53_22573176_ChIP-Seq_HFKS_Human1.27839261
62SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.27478761
63POU5F1_16153702_ChIP-ChIP_HESCs_Human1.26299288
64HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.25867780
65CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.25010190
66IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.24199660
67ERG_20517297_ChIP-Seq_VCAP_Human1.23955062
68RNF2_27304074_Chip-Seq_ESCs_Mouse1.22101812
69TP63_17297297_ChIP-ChIP_HaCaT_Human1.21243630
70NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.21024130
71SRY_22984422_ChIP-ChIP_TESTIS_Rat1.20521771
72THAP11_20581084_ChIP-Seq_MESCs_Mouse1.20435596
73TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.19389645
74* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.19200084
75ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.17582243
76AR_20517297_ChIP-Seq_VCAP_Human1.17018175
77CTBP2_25329375_ChIP-Seq_LNCAP_Human1.16773329
78NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.15775360
79MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.14658198
80BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.13841097
81AR_21572438_ChIP-Seq_LNCaP_Human1.13493354
82E2F1_18555785_ChIP-Seq_MESCs_Mouse1.13213229
83* SPI1_23547873_ChIP-Seq_NB4_Human1.11835102
84DCP1A_22483619_ChIP-Seq_HELA_Human1.11663704
85* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11398739
86CDX2_19796622_ChIP-Seq_MESCs_Mouse1.10370653
87* TP53_20018659_ChIP-ChIP_R1E_Mouse1.09462185
88EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.08896002
89GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08775686
90FUS_26573619_Chip-Seq_HEK293_Human1.08574286
91CTCF_18555785_ChIP-Seq_MESCs_Mouse1.08409708
92PADI4_21655091_ChIP-ChIP_MCF-7_Human1.08023611
93HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.05524553
94FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.05421175
95CREB1_15753290_ChIP-ChIP_HEK293T_Human1.04712872
96YY1_21170310_ChIP-Seq_MESCs_Mouse1.04319401
97MYC_19079543_ChIP-ChIP_MESCs_Mouse1.03996806
98RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.03108055
99GBX2_23144817_ChIP-Seq_PC3_Human1.02667870
100FOXA1_27270436_Chip-Seq_PROSTATE_Human1.01980339
101FOXA1_25329375_ChIP-Seq_VCAP_Human1.01980339
102POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01706897
103EWS_26573619_Chip-Seq_HEK293_Human1.01572361
104CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.01051974
105GATA3_26560356_Chip-Seq_TH2_Human0.99959682
106MYC_18555785_ChIP-Seq_MESCs_Mouse0.98311459
107* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.98144721
108* GABP_19822575_ChIP-Seq_HepG2_Human0.97749966
109RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.97440020
110MYC_19030024_ChIP-ChIP_MESCs_Mouse0.96863803
111PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.96849661
112PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.96606259
113PCGF2_27294783_Chip-Seq_ESCs_Mouse0.96079094
114P300_19829295_ChIP-Seq_ESCs_Human0.95341990
115EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.93856539
116FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.92626997
117TAF2_19829295_ChIP-Seq_ESCs_Human0.91764263
118CTCF_26484167_Chip-Seq_Bcells_Mouse0.91511092
119REST_21632747_ChIP-Seq_MESCs_Mouse0.91493915
120* VDR_23849224_ChIP-Seq_CD4+_Human0.89897975
121GATA3_21878914_ChIP-Seq_MCF-7_Human0.87938098
122* SRF_21415370_ChIP-Seq_HL-1_Mouse0.86926671
123SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.86419791
124CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.86314706
125MYC_19829295_ChIP-Seq_ESCs_Human0.85390308
126NANOG_20526341_ChIP-Seq_ESCs_Human0.85298295
127KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.85106164
128PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.84973762
129XRN2_22483619_ChIP-Seq_HELA_Human0.83934750
130FLI1_27457419_Chip-Seq_LIVER_Mouse0.83527450
131P300_27268052_Chip-Seq_Bcells_Human0.82388277
132ETV2_25802403_ChIP-Seq_MESCs_Mouse0.82095311
133NANOG_19829295_ChIP-Seq_ESCs_Human0.82066597
134SOX2_19829295_ChIP-Seq_ESCs_Human0.82066597
135YY1_22570637_ChIP-Seq_MALME-3M_Human0.81572921
136TOP2B_26459242_ChIP-Seq_MCF-7_Human0.80770865
137HTT_18923047_ChIP-ChIP_STHdh_Human0.80034547
138BCL6_27268052_Chip-Seq_Bcells_Human0.79937240
139SMC3_22415368_ChIP-Seq_MEFs_Mouse0.79399392
140RING1B_27294783_Chip-Seq_ESCs_Mouse0.79220196
141GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.78403810
142* MYC_18940864_ChIP-ChIP_HL60_Human0.76050251
143TRIM28_21343339_ChIP-Seq_HEK293_Human0.75960584
144ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.75810155
145PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.73280929
146RAD21_21589869_ChIP-Seq_MESCs_Mouse0.72212294
147REST_18959480_ChIP-ChIP_MESCs_Mouse0.72182437
148LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.72127117
149RING1B_27294783_Chip-Seq_NPCs_Mouse0.71222707
150PCGF2_27294783_Chip-Seq_NPCs_Mouse0.70440161
151ER_23166858_ChIP-Seq_MCF-7_Human0.70387834
152MYC_18358816_ChIP-ChIP_MESCs_Mouse0.70050945
153SA1_22415368_ChIP-Seq_MEFs_Mouse0.69420321

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation6.12453920
2MP0003880_abnormal_central_pattern3.83253224
3MP0003136_yellow_coat_color3.15224682
4MP0002163_abnormal_gland_morphology2.85257795
5MP0003806_abnormal_nucleotide_metabolis2.69523016
6MP0006276_abnormal_autonomic_nervous2.45125891
7MP0010386_abnormal_urinary_bladder2.35090887
8MP0001905_abnormal_dopamine_level2.34002552
9MP0002009_preneoplasia2.26655419
10MP0002638_abnormal_pupillary_reflex2.26492206
11MP0003186_abnormal_redox_activity2.22453096
12MP0005379_endocrine/exocrine_gland_phen2.14861579
13MP0005171_absent_coat_pigmentation2.13493414
14MP0001529_abnormal_vocalization2.08813046
15MP0005645_abnormal_hypothalamus_physiol2.02179500
16MP0009785_altered_susceptibility_to1.97667173
17MP0005075_abnormal_melanosome_morpholog1.97272332
18MP0004381_abnormal_hair_follicle1.93355829
19MP0005174_abnormal_tail_pigmentation1.89312186
20MP0001968_abnormal_touch/_nociception1.88765073
21MP0005409_darkened_coat_color1.86875971
22MP0001188_hyperpigmentation1.82578814
23MP0002277_abnormal_respiratory_mucosa1.81364486
24MP0002736_abnormal_nociception_after1.67745816
25MP0006036_abnormal_mitochondrial_physio1.67153496
26MP0005423_abnormal_somatic_nervous1.63548664
27MP0001970_abnormal_pain_threshold1.60172046
28MP0001346_abnormal_lacrimal_gland1.57471396
29MP0001800_abnormal_humoral_immune1.55817196
30MP0002095_abnormal_skin_pigmentation1.51788531
31MP0002723_abnormal_immune_serum1.48088114
32MP0000372_irregular_coat_pigmentation1.47695938
33MP0002572_abnormal_emotion/affect_behav1.46933327
34MP0005025_abnormal_response_to1.45184090
35MP0001440_abnormal_grooming_behavior1.43563658
36MP0004142_abnormal_muscle_tone1.43412940
37MP0002938_white_spotting1.42838026
38MP0002653_abnormal_ependyma_morphology1.40942429
39MP0005646_abnormal_pituitary_gland1.40161383
40MP0001853_heart_inflammation1.38825098
41MP0002148_abnormal_hypersensitivity_rea1.37929597
42MP0000685_abnormal_immune_system1.36586770
43MP0001986_abnormal_taste_sensitivity1.35905230
44MP0002272_abnormal_nervous_system1.34959566
45MP0002420_abnormal_adaptive_immunity1.34672112
46MP0002452_abnormal_antigen_presenting1.34581341
47MP0002064_seizures1.33324186
48MP0002102_abnormal_ear_morphology1.33215964
49MP0009745_abnormal_behavioral_response1.33196340
50MP0001819_abnormal_immune_cell1.32826910
51MP0004147_increased_porphyrin_level1.29903283
52MP0002796_impaired_skin_barrier1.29210769
53MP0003283_abnormal_digestive_organ1.28865308
54MP0000778_abnormal_nervous_system1.27999532
55MP0009333_abnormal_splenocyte_physiolog1.27967802
56MP0000538_abnormal_urinary_bladder1.26864033
57MP0002733_abnormal_thermal_nociception1.26838870
58MP0002822_catalepsy1.26267976
59MP0001984_abnormal_olfaction1.24874322
60MP0002282_abnormal_trachea_morphology1.22300860
61MP0002837_dystrophic_cardiac_calcinosis1.22193158
62MP0004742_abnormal_vestibular_system1.21315223
63MP0002735_abnormal_chemical_nociception1.18201012
64MP0002419_abnormal_innate_immunity1.17296463
65MP0000049_abnormal_middle_ear1.14911730
66MP0000762_abnormal_tongue_morphology1.14487309
67MP0003941_abnormal_skin_development1.14126741
68MP0008875_abnormal_xenobiotic_pharmacok1.13717883
69MP0001845_abnormal_inflammatory_respons1.13692590
70MP0004019_abnormal_vitamin_homeostasis1.11474957
71MP0003436_decreased_susceptibility_to1.11413971
72* MP0006072_abnormal_retinal_apoptosis1.10453641
73MP0009046_muscle_twitch1.08147029
74MP0003635_abnormal_synaptic_transmissio1.06976830
75MP0003724_increased_susceptibility_to1.06593774
76MP0002405_respiratory_system_inflammati1.06526422
77MP0002734_abnormal_mechanical_nocicepti1.05171670
78MP0002063_abnormal_learning/memory/cond1.04821256
79MP0001501_abnormal_sleep_pattern1.04700206
80MP0002184_abnormal_innervation1.04575044
81MP0002876_abnormal_thyroid_physiology1.04075799
82MP0001727_abnormal_embryo_implantation1.03271279
83MP0000026_abnormal_inner_ear1.03024161
84MP0009764_decreased_sensitivity_to1.02244451
85MP0002751_abnormal_autonomic_nervous1.01411224
86MP0002928_abnormal_bile_duct1.01005385
87MP0002249_abnormal_larynx_morphology1.00022794
88MP0004885_abnormal_endolymph0.99936060
89MP0003011_delayed_dark_adaptation0.99811936
90MP0008469_abnormal_protein_level0.99697668
91MP0002693_abnormal_pancreas_physiology0.99471531
92MP0002557_abnormal_social/conspecific_i0.98221206
93MP0000631_abnormal_neuroendocrine_gland0.96082121
94MP0001664_abnormal_digestion0.96002582
95MP0001764_abnormal_homeostasis0.95119633
96MP0008789_abnormal_olfactory_epithelium0.94868326
97MP0002132_abnormal_respiratory_system0.94629035
98MP0000343_altered_response_to0.94169076
99MP0003938_abnormal_ear_development0.94061509
100MP0002138_abnormal_hepatobiliary_system0.92886699
101MP0002067_abnormal_sensory_capabilities0.91070371
102MP0009250_abnormal_appendicular_skeleto0.90916584
103MP0005410_abnormal_fertilization0.90902970
104MP0000462_abnormal_digestive_system0.89147726
105MP0003763_abnormal_thymus_physiology0.88990659
106MP0004133_heterotaxia0.88971483
107MP0000716_abnormal_immune_system0.88637809
108MP0000015_abnormal_ear_pigmentation0.88499871
109MP0003195_calcinosis0.87136558
110MP0006292_abnormal_olfactory_placode0.86903017
111MP0006035_abnormal_mitochondrial_morpho0.86900022
112MP0003315_abnormal_perineum_morphology0.86777027
113MP0001756_abnormal_urination0.86384721
114MP0000613_abnormal_salivary_gland0.85698579
115MP0001485_abnormal_pinna_reflex0.85522245
116MP0001873_stomach_inflammation0.83995156
117MP0008872_abnormal_physiological_respon0.83335078
118MP0003122_maternal_imprinting0.82700957
119MP0003878_abnormal_ear_physiology0.81435815
120MP0005377_hearing/vestibular/ear_phenot0.81435815
121MP0001502_abnormal_circadian_rhythm0.81220411
122MP0008004_abnormal_stomach_pH0.80966159
123MP0001835_abnormal_antigen_presentation0.80952787
124MP0002166_altered_tumor_susceptibility0.80438900
125MP0005058_abnormal_lysosome_morphology0.79857190
126MP0003866_abnormal_defecation0.79339976
127MP0000681_abnormal_thyroid_gland0.78904690
128MP0002006_tumorigenesis0.78299413
129MP0005381_digestive/alimentary_phenotyp0.77378948
130MP0005636_abnormal_mineral_homeostasis0.76748117
131MP0001340_abnormal_eyelid_morphology0.75657967
132MP0000689_abnormal_spleen_morphology0.75548069
133* MP0002752_abnormal_somatic_nervous0.75414328
134MP0001486_abnormal_startle_reflex0.75049234
135* MP0005551_abnormal_eye_electrophysiolog0.74868084
136MP0002909_abnormal_adrenal_gland0.74855590
137MP0001963_abnormal_hearing_physiology0.74642678
138MP0002933_joint_inflammation0.73377112
139MP0009643_abnormal_urine_homeostasis0.73222203
140MP0010030_abnormal_orbit_morphology0.72275954
141MP0001533_abnormal_skeleton_physiology0.72137666
142MP0005671_abnormal_response_to0.72119292
143* MP0005253_abnormal_eye_physiology0.72054001
144MP0006082_CNS_inflammation0.71702165
145MP0000920_abnormal_myelination0.71459049
146MP0005408_hypopigmentation0.71282921
147MP0005084_abnormal_gallbladder_morpholo0.71139917
148MP0003638_abnormal_response/metabolism_0.71089317
149MP0000470_abnormal_stomach_morphology0.66609516
150MP0001790_abnormal_immune_system0.66516582
151MP0005387_immune_system_phenotype0.66516582
152MP0005000_abnormal_immune_tolerance0.64312655
153MP0005310_abnormal_salivary_gland0.64261563

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.13510951
2Abnormality of cells of the erythroid lineage (HP:0012130)6.11779997
3Mitochondrial inheritance (HP:0001427)5.37781580
4Abnormal mitochondria in muscle tissue (HP:0008316)5.34185703
5Progressive macrocephaly (HP:0004481)5.30925784
6Abnormal number of erythroid precursors (HP:0012131)5.22287791
7Acute encephalopathy (HP:0006846)4.80112373
8Reticulocytopenia (HP:0001896)4.80058854
9Increased hepatocellular lipid droplets (HP:0006565)4.63502277
10Macrocytic anemia (HP:0001972)4.27138336
11Renal Fanconi syndrome (HP:0001994)4.16033638
12Abnormal hemoglobin (HP:0011902)4.09031002
13Increased CSF lactate (HP:0002490)4.05785300
14Hepatocellular necrosis (HP:0001404)3.97791055
15Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.92181215
16Lipid accumulation in hepatocytes (HP:0006561)3.90866119
17Exertional dyspnea (HP:0002875)3.78810154
18Concave nail (HP:0001598)3.68424875
19Pallor (HP:0000980)3.62993863
20Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.56596531
21Abnormal respiratory epithelium morphology (HP:0012253)3.36114321
22Abnormal respiratory motile cilium morphology (HP:0005938)3.36114321
23Optic disc pallor (HP:0000543)3.35127476
24Parakeratosis (HP:0001036)3.27355623
25Increased intramyocellular lipid droplets (HP:0012240)3.18846110
26Abnormal ciliary motility (HP:0012262)3.18833217
27Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.18330584
28Hepatic necrosis (HP:0002605)3.07682898
293-Methylglutaconic aciduria (HP:0003535)3.00179513
30Exercise intolerance (HP:0003546)2.95031138
31Increased IgM level (HP:0003496)2.94221919
32Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.87827112
33Decreased activity of mitochondrial respiratory chain (HP:0008972)2.87827112
34Abnormal respiratory motile cilium physiology (HP:0012261)2.87287907
35Respiratory failure (HP:0002878)2.87164108
36Abnormality of the axillary hair (HP:0100134)2.84695990
37Abnormality of secondary sexual hair (HP:0009888)2.84695990
38Pancreatic cysts (HP:0001737)2.79743230
39Cerebral edema (HP:0002181)2.76295966
40Aplasia/Hypoplasia of the sacrum (HP:0008517)2.75279579
41Abnormality of renal resorption (HP:0011038)2.75276210
42Pancreatic fibrosis (HP:0100732)2.74814241
43Leukodystrophy (HP:0002415)2.72689943
44Congenital ichthyosiform erythroderma (HP:0007431)2.69301187
45Aplastic anemia (HP:0001915)2.63737523
46Abnormality of midbrain morphology (HP:0002418)2.61928228
47Molar tooth sign on MRI (HP:0002419)2.61928228
48Stomatitis (HP:0010280)2.56262418
49Abnormality of placental membranes (HP:0011409)2.53905878
50Amniotic constriction ring (HP:0009775)2.53905878
51True hermaphroditism (HP:0010459)2.52805900
52Increased muscle lipid content (HP:0009058)2.52529693
53Respiratory difficulties (HP:0002880)2.51749278
54Elevated erythrocyte sedimentation rate (HP:0003565)2.45799186
55Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.45194710
56Hypothermia (HP:0002045)2.44694547
57Absent/shortened dynein arms (HP:0200106)2.35279853
58Dynein arm defect of respiratory motile cilia (HP:0012255)2.35279853
59Medial flaring of the eyebrow (HP:0010747)2.33141480
60Nephronophthisis (HP:0000090)2.27889374
61Congenital stationary night blindness (HP:0007642)2.25548920
62Myokymia (HP:0002411)2.23466223
63Lactic acidosis (HP:0003128)2.23282812
64Rhinitis (HP:0012384)2.20469366
65Generalized aminoaciduria (HP:0002909)2.15843179
66Hyperphosphaturia (HP:0003109)2.14851945
67X-linked dominant inheritance (HP:0001423)2.11139097
68Fragile nails (HP:0001808)2.09398367
69Congenital, generalized hypertrichosis (HP:0004540)2.07623172
70Lethargy (HP:0001254)2.03670432
71Hypotrichosis (HP:0001006)2.03131383
72Oral leukoplakia (HP:0002745)2.02643398
73Abnormality of glycosphingolipid metabolism (HP:0004343)2.02198115
74Abnormality of glycolipid metabolism (HP:0010969)2.02198115
75Abnormality of liposaccharide metabolism (HP:0010968)2.02198115
76Gait imbalance (HP:0002141)2.01044774
77Congenital primary aphakia (HP:0007707)1.99418307
78Vacuolated lymphocytes (HP:0001922)1.99321219
79Increased serum lactate (HP:0002151)1.93941024
80CNS demyelination (HP:0007305)1.93617192
81Stenosis of the external auditory canal (HP:0000402)1.86409185
82Type I transferrin isoform profile (HP:0003642)1.86303751
83Popliteal pterygium (HP:0009756)1.85381658
84Abnormal rod and cone electroretinograms (HP:0008323)1.85375238
85Aplasia/hypoplasia of the uterus (HP:0008684)1.84489695
86Sensory axonal neuropathy (HP:0003390)1.83218460
87Abnormal urine phosphate concentration (HP:0012599)1.80308262
88Vaginal atresia (HP:0000148)1.79921452
89Methylmalonic acidemia (HP:0002912)1.79401693
90Abnormality of the renal medulla (HP:0100957)1.78815627
91Retinal dysplasia (HP:0007973)1.78281506
92Nephrogenic diabetes insipidus (HP:0009806)1.76582550
93Genital tract atresia (HP:0001827)1.73603625
94Large for gestational age (HP:0001520)1.73503928
95Limb dystonia (HP:0002451)1.73494247
96Aplasia cutis congenita (HP:0001057)1.72269407
97Woolly hair (HP:0002224)1.72168541
98Depressed nasal ridge (HP:0000457)1.70935127
99Hypoplasia of the ulna (HP:0003022)1.70020649
100Recurrent bacterial skin infections (HP:0005406)1.69450053
101Abnormality of the renal cortex (HP:0011035)1.68265329
102Hypoplasia of the radius (HP:0002984)1.67415593
103Recurrent abscess formation (HP:0002722)1.67113260
104IgM deficiency (HP:0002850)1.66368618
105Panhypogammaglobulinemia (HP:0003139)1.66087962
106Abnormal biliary tract physiology (HP:0012439)1.66081551
107Bile duct proliferation (HP:0001408)1.66081551
108Abnormal pupillary function (HP:0007686)1.65949238
109Sclerocornea (HP:0000647)1.64343893
110Recurrent sinusitis (HP:0011108)1.64017085
111Pancytopenia (HP:0001876)1.63366782
112Abnormality of the prostate (HP:0008775)1.63275192
113IgG deficiency (HP:0004315)1.63178456
114Dicarboxylic aciduria (HP:0003215)1.61706755
115Abnormality of dicarboxylic acid metabolism (HP:0010995)1.61706755
116Neutropenia (HP:0001875)1.61486492
117Thrombocytosis (HP:0001894)1.60978417
118Renal tubular dysfunction (HP:0000124)1.60654250
119Methylmalonic aciduria (HP:0012120)1.59280044
120Abnormal autonomic nervous system physiology (HP:0012332)1.59074474
121Degeneration of anterior horn cells (HP:0002398)1.58753813
122Abnormality of the anterior horn cell (HP:0006802)1.58753813
123Septo-optic dysplasia (HP:0100842)1.58321310
124Abnormal drinking behavior (HP:0030082)1.57078875
125Polydipsia (HP:0001959)1.57078875
126Emotional lability (HP:0000712)1.55697422
127Amelogenesis imperfecta (HP:0000705)1.55583897
128Esotropia (HP:0000565)1.54959982
129Abnormality of urine glucose concentration (HP:0011016)1.54766133
130Glycosuria (HP:0003076)1.54766133
131Increased serum pyruvate (HP:0003542)1.54198812
132Abnormality of glycolysis (HP:0004366)1.54198812
133Patchy hypopigmentation of hair (HP:0011365)1.53902283
134Aplasia/Hypoplasia of the lens (HP:0008063)1.53528432
135Chronic sinusitis (HP:0011109)1.52750061
136Obstructive lung disease (HP:0006536)1.51019454
137Chronic obstructive pulmonary disease (HP:0006510)1.51019454
138Migraine (HP:0002076)1.49372453
139Bronchiectasis (HP:0002110)1.48247421
140Nasolacrimal duct obstruction (HP:0000579)1.48190442
141Absent rod-and cone-mediated responses on ERG (HP:0007688)1.47486850
142Polyphagia (HP:0002591)1.46763165
143Partial duplication of thumb phalanx (HP:0009944)1.45294027
144Hypertensive crisis (HP:0100735)1.42961708
145Congenital sensorineural hearing impairment (HP:0008527)1.42690844

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.00731901
2MAP3K123.81105150
3NME23.31018191
4NME13.21651688
5MAPK153.07250946
6MST43.01095676
7TLK12.50119521
8FGR2.42422618
9PASK2.39928781
10CASK2.26461264
11MYLK2.17246955
12TAOK32.07421905
13CDK192.04888677
14ZAK2.03417389
15TESK22.03115526
16STK391.99429371
17PIM21.96492546
18UHMK11.95734225
19GRK71.82442659
20MAP4K21.79273084
21RIPK41.78143662
22STK161.77519335
23BMPR1B1.71145423
24MUSK1.65241672
25MAP2K61.63845595
26BCKDK1.61291842
27MAP4K11.57896948
28GRK51.48172804
29PBK1.47160493
30BMPR21.39754733
31ARAF1.36783064
32KIT1.33997446
33OXSR11.33562110
34WNK41.33163998
35NUAK11.32665518
36PRKD21.31612541
37ADRBK21.31428774
38DYRK21.30338129
39ITK1.29861228
40TEC1.25718237
41MST1R1.25386259
42KDR1.25058935
43MAPKAPK51.23452549
44YES11.23000553
45ILK1.22276408
46MAP3K61.19157793
47TBK11.16026146
48CAMK2B1.12819169
49INSRR1.12206777
50LIMK11.11764616
51MATK1.10962822
52TAOK21.10069361
53IKBKE1.07335384
54VRK11.06647717
55MAP3K111.04050277
56TNIK1.01142947
57FGFR21.00802115
58TYK20.99372341
59BCR0.99053577
60DAPK30.98294953
61EPHB20.94661280
62MAP2K70.94592888
63PNCK0.93328473
64NTRK20.93204727
65MAPK130.92481917
66ADRBK10.90920750
67CAMK2A0.89463365
68BLK0.88591727
69CAMKK20.84353914
70DAPK10.83743155
71CAMK2D0.83372145
72CSF1R0.80435716
73GRK10.80219859
74FES0.80208261
75PKN10.79693069
76PRKCQ0.79439555
77MAPKAPK30.78312100
78BTK0.78213440
79DDR20.76968855
80LRRK20.75519945
81TNK20.73388778
82CAMK2G0.71497545
83PRKCE0.69582399
84TGFBR10.69248419
85CSNK1G30.68745554
86WNK30.68210285
87FRK0.68150655
88IRAK20.68130828
89MAP2K20.65416448
90CSNK1G10.65006711
91SYK0.64884463
92DYRK1B0.64532018
93ROCK20.63888441
94MARK10.62736962
95PDK20.61687166
96TIE10.61662532
97CSK0.61498734
98IKBKB0.61197238
99PHKG10.60863636
100PHKG20.60863636
101LYN0.59669421
102SRPK10.59008347
103CDK80.58769605
104EPHA40.58273048
105MAPK40.57886515
106RPS6KC10.56672956
107RPS6KL10.56672956
108ABL20.55022501
109PTK2B0.53623734
110TXK0.53466985
111ZAP700.52575719
112PRKACA0.51598658
113IRAK40.50487448
114ERBB30.50481720
115PRKCG0.50336995
116RPS6KA50.49665123
117SIK20.49604162
118CDK30.48315623
119RPS6KA60.48151072
120CSNK2A10.46163987
121PIK3CG0.46129779
122HIPK20.45939834
123LCK0.45663086
124TRPM70.45063760
125GRK60.44082818
126JAK30.43917980
127OBSCN0.42835099
128GSK3A0.42255634
129BRAF0.41417934
130CSNK2A20.40809438
131MARK30.40482952
132CSNK1G20.40445730
133CDK50.39450935
134PRKCD0.39264643
135PINK10.39074950
136PRKCA0.37862427
137DAPK20.37680802
138MAP3K40.37678566
139TESK10.36221320
140PIM10.35014299
141HCK0.33582899
142ABL10.31085136
143CSNK1A10.28399723

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.59353368
2Oxidative phosphorylation_Homo sapiens_hsa001905.94236951
3Parkinsons disease_Homo sapiens_hsa050124.92121761
4Alzheimers disease_Homo sapiens_hsa050103.97209128
5Huntingtons disease_Homo sapiens_hsa050163.60671398
6Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.16660222
7Protein export_Homo sapiens_hsa030602.81573867
8Proteasome_Homo sapiens_hsa030502.58551653
9Cardiac muscle contraction_Homo sapiens_hsa042602.46888526
10RNA polymerase_Homo sapiens_hsa030202.01788102
11Collecting duct acid secretion_Homo sapiens_hsa049661.80440172
12Antigen processing and presentation_Homo sapiens_hsa046121.53887749
13Graft-versus-host disease_Homo sapiens_hsa053321.30321061
14Phototransduction_Homo sapiens_hsa047441.26588232
15Vibrio cholerae infection_Homo sapiens_hsa051101.24503347
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.19427698
17Nicotine addiction_Homo sapiens_hsa050331.17446421
18Rheumatoid arthritis_Homo sapiens_hsa053231.17443437
19Serotonergic synapse_Homo sapiens_hsa047261.09657962
20Staphylococcus aureus infection_Homo sapiens_hsa051501.04581509
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.00478102
22Fatty acid elongation_Homo sapiens_hsa000620.96616532
23SNARE interactions in vesicular transport_Homo sapiens_hsa041300.96193002
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.95486288
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.92426273
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.90601185
27Regulation of autophagy_Homo sapiens_hsa041400.90102315
28Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.89734884
29Sulfur metabolism_Homo sapiens_hsa009200.88731233
30Taste transduction_Homo sapiens_hsa047420.85242899
31Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85100885
32Peroxisome_Homo sapiens_hsa041460.83733416
33Ether lipid metabolism_Homo sapiens_hsa005650.82471967
34Arachidonic acid metabolism_Homo sapiens_hsa005900.80961018
35Nitrogen metabolism_Homo sapiens_hsa009100.79474068
36Primary immunodeficiency_Homo sapiens_hsa053400.78267064
37Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.77850965
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.77232382
39Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.74243427
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.73688440
41Leishmaniasis_Homo sapiens_hsa051400.72354719
42GABAergic synapse_Homo sapiens_hsa047270.70996849
43Allograft rejection_Homo sapiens_hsa053300.69309334
44Chemical carcinogenesis_Homo sapiens_hsa052040.69244394
45Folate biosynthesis_Homo sapiens_hsa007900.69080202
46Other glycan degradation_Homo sapiens_hsa005110.68423436
47Spliceosome_Homo sapiens_hsa030400.68175374
48RNA degradation_Homo sapiens_hsa030180.67139079
49Autoimmune thyroid disease_Homo sapiens_hsa053200.67122447
50Morphine addiction_Homo sapiens_hsa050320.66144158
51Butanoate metabolism_Homo sapiens_hsa006500.65392973
52Renin secretion_Homo sapiens_hsa049240.64064571
53Long-term depression_Homo sapiens_hsa047300.63688193
54Sulfur relay system_Homo sapiens_hsa041220.63380663
55Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.60558541
56Linoleic acid metabolism_Homo sapiens_hsa005910.60414065
57Systemic lupus erythematosus_Homo sapiens_hsa053220.60000291
58Phagosome_Homo sapiens_hsa041450.58842618
59Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.57987996
60Glutamatergic synapse_Homo sapiens_hsa047240.57742765
61Sphingolipid metabolism_Homo sapiens_hsa006000.56862812
62Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.55599637
63Basal transcription factors_Homo sapiens_hsa030220.55323678
64Pyrimidine metabolism_Homo sapiens_hsa002400.55019577
65Amphetamine addiction_Homo sapiens_hsa050310.54146462
66Lysosome_Homo sapiens_hsa041420.53398672
67Primary bile acid biosynthesis_Homo sapiens_hsa001200.53041350
68Intestinal immune network for IgA production_Homo sapiens_hsa046720.52619808
69Asthma_Homo sapiens_hsa053100.50629575
70Synaptic vesicle cycle_Homo sapiens_hsa047210.49879352
71Viral myocarditis_Homo sapiens_hsa054160.49281176
72Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49113636
73Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.48579099
74Dopaminergic synapse_Homo sapiens_hsa047280.47598085
75Circadian entrainment_Homo sapiens_hsa047130.46068624
76African trypanosomiasis_Homo sapiens_hsa051430.45774350
77Nucleotide excision repair_Homo sapiens_hsa034200.44063837
78Glutathione metabolism_Homo sapiens_hsa004800.43347636
79Salivary secretion_Homo sapiens_hsa049700.42944071
80Tryptophan metabolism_Homo sapiens_hsa003800.42868006
81Pancreatic secretion_Homo sapiens_hsa049720.41205452
82Axon guidance_Homo sapiens_hsa043600.39663196
83Gastric acid secretion_Homo sapiens_hsa049710.39562588
84Metabolic pathways_Homo sapiens_hsa011000.39282127
85Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.38983807
86Melanogenesis_Homo sapiens_hsa049160.38909372
87Cocaine addiction_Homo sapiens_hsa050300.38773992
88Cholinergic synapse_Homo sapiens_hsa047250.38550257
89Calcium signaling pathway_Homo sapiens_hsa040200.37735805
90NOD-like receptor signaling pathway_Homo sapiens_hsa046210.37565676
91Olfactory transduction_Homo sapiens_hsa047400.37550966
92Maturity onset diabetes of the young_Homo sapiens_hsa049500.37542405
93Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.37211979
94Type I diabetes mellitus_Homo sapiens_hsa049400.37086253
95Mineral absorption_Homo sapiens_hsa049780.36076753
96Epstein-Barr virus infection_Homo sapiens_hsa051690.35850305
97Propanoate metabolism_Homo sapiens_hsa006400.35430539
98Hedgehog signaling pathway_Homo sapiens_hsa043400.35090584
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.33923959
100Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.33523846
101Hematopoietic cell lineage_Homo sapiens_hsa046400.33174384
102Purine metabolism_Homo sapiens_hsa002300.32781350
103Vascular smooth muscle contraction_Homo sapiens_hsa042700.32467071
104alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32318091
105Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.31918198
106Homologous recombination_Homo sapiens_hsa034400.31636631
107Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.31481150
108Mismatch repair_Homo sapiens_hsa034300.29855653
109GnRH signaling pathway_Homo sapiens_hsa049120.29644000
110NF-kappa B signaling pathway_Homo sapiens_hsa040640.29560458
111Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.29305039
112Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.28305537
113Gap junction_Homo sapiens_hsa045400.28020332
114Ras signaling pathway_Homo sapiens_hsa040140.27844271
115Long-term potentiation_Homo sapiens_hsa047200.26573239
116Alcoholism_Homo sapiens_hsa050340.26480256
117Tuberculosis_Homo sapiens_hsa051520.24533130
118Legionellosis_Homo sapiens_hsa051340.23705323
119Malaria_Homo sapiens_hsa051440.23276743
120Oxytocin signaling pathway_Homo sapiens_hsa049210.23028985
121Pertussis_Homo sapiens_hsa051330.21912458
122Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.21597571
123Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.21235977
124Wnt signaling pathway_Homo sapiens_hsa043100.19861335
125Insulin secretion_Homo sapiens_hsa049110.19478344
126Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.19157445
127Fanconi anemia pathway_Homo sapiens_hsa034600.19137410
128Tyrosine metabolism_Homo sapiens_hsa003500.18922475
129RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.18620489
130T cell receptor signaling pathway_Homo sapiens_hsa046600.18370861
131Sphingolipid signaling pathway_Homo sapiens_hsa040710.17736994
132Glycosaminoglycan degradation_Homo sapiens_hsa005310.17518803
133VEGF signaling pathway_Homo sapiens_hsa043700.16666056
134Herpes simplex infection_Homo sapiens_hsa051680.16537238
135Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.16488908
136One carbon pool by folate_Homo sapiens_hsa006700.16009835
137Retinol metabolism_Homo sapiens_hsa008300.15722443
138Drug metabolism - other enzymes_Homo sapiens_hsa009830.08251515
139Toxoplasmosis_Homo sapiens_hsa051450.07122033

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