PF4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet aggregation. This protein is chemotactic for numerous other cell type and also functions as an inhibitor of hematopoiesis, angiogenesis and T-cell function. The protein also exhibits antimicrobial activity against Plasmodium falciparum. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1eosinophil chemotaxis (GO:0048245)9.79435942
2eosinophil migration (GO:0072677)8.67846143
3neutrophil activation involved in immune response (GO:0002283)7.47803774
4thrombin receptor signaling pathway (GO:0070493)7.25470098
5protein neddylation (GO:0045116)6.53458031
6regulation of platelet aggregation (GO:0090330)6.44260056
7positive regulation of monocyte chemotaxis (GO:0090026)5.92674271
8leukocyte migration involved in inflammatory response (GO:0002523)5.78900856
9macrophage activation involved in immune response (GO:0002281)5.57717155
10monocyte chemotaxis (GO:0002548)5.52735121
11modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.45963775
12positive regulation by organism of defense response of other organism involved in symbiotic interact5.45963775
13modulation by symbiont of host immune response (GO:0052553)5.45963775
14positive regulation by symbiont of host defense response (GO:0052509)5.45963775
15modulation by symbiont of host defense response (GO:0052031)5.45963775
16modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.45963775
17response to peptidoglycan (GO:0032494)5.43854270
18platelet aggregation (GO:0070527)5.30582617
19blood coagulation, intrinsic pathway (GO:0007597)5.20137714
20pinocytosis (GO:0006907)5.15941186
21negative regulation of homotypic cell-cell adhesion (GO:0034111)5.15147988
22granulocyte activation (GO:0036230)4.98156773
23antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.97327877
24positive regulation of mast cell activation (GO:0033005)4.91444971
25microglial cell activation (GO:0001774)4.91247597
26adenosine receptor signaling pathway (GO:0001973)4.86835156
27regulation of lymphocyte chemotaxis (GO:1901623)4.83578628
28negative regulation of thymocyte apoptotic process (GO:0070244)4.81681612
29detection of molecule of bacterial origin (GO:0032490)4.77475096
30negative regulation of platelet activation (GO:0010544)4.69281936
31myeloid cell activation involved in immune response (GO:0002275)4.58984556
32triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.52670247
33cellular extravasation (GO:0045123)4.48404782
34macrophage activation (GO:0042116)4.46646935
35angiogenesis involved in wound healing (GO:0060055)4.42563899
36phagocytosis, engulfment (GO:0006911)4.41603272
37positive regulation of lymphocyte migration (GO:2000403)4.41533826
38regulation of integrin-mediated signaling pathway (GO:2001044)4.37000696
39positive regulation of endothelial cell differentiation (GO:0045603)4.36218842
40regulation of monocyte chemotaxis (GO:0090025)4.35899808
41cellular response to ethanol (GO:0071361)4.32775616
42neutrophil activation (GO:0042119)4.32073224
43lipoxygenase pathway (GO:0019372)4.31905468
44negative regulation of norepinephrine secretion (GO:0010700)4.27126214
45regulation of integrin activation (GO:0033623)4.24067772
46regulation of mononuclear cell migration (GO:0071675)4.17148248
47positive regulation of cellular amide metabolic process (GO:0034250)4.10437144
48lipopolysaccharide-mediated signaling pathway (GO:0031663)4.06066600
49production of molecular mediator involved in inflammatory response (GO:0002532)4.06021356
50lymphocyte chemotaxis (GO:0048247)4.05666441
51negative regulation of heart rate (GO:0010459)4.02811134
52respiratory burst (GO:0045730)4.02083492
53T-helper 1 type immune response (GO:0042088)4.01210981
54megakaryocyte development (GO:0035855)4.00391710
55positive regulation of antigen processing and presentation (GO:0002579)3.99126497
56negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.95727135
57regulation of lymphocyte migration (GO:2000401)3.90231972
58homotypic cell-cell adhesion (GO:0034109)3.87265898
59purinergic nucleotide receptor signaling pathway (GO:0035590)3.85783561
60regulation of homotypic cell-cell adhesion (GO:0034110)3.84018965
61regulation of B cell receptor signaling pathway (GO:0050855)3.74863049
62polyamine biosynthetic process (GO:0006596)3.74193985
63granulocyte chemotaxis (GO:0071621)3.73829402
64negative regulation of T-helper cell differentiation (GO:0045623)3.73232710
65negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.73232710
66regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.69432030
67* platelet degranulation (GO:0002576)3.65806535
68low-density lipoprotein particle remodeling (GO:0034374)3.63151276
69negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.61832906
70platelet formation (GO:0030220)3.59290567
71granulocyte migration (GO:0097530)3.57513105
72positive regulation of hemostasis (GO:1900048)3.56794612
73positive regulation of blood coagulation (GO:0030194)3.56794612
74sexual reproduction (GO:0019953)3.55822674
75cytidine deamination (GO:0009972)3.52823323
76cytidine metabolic process (GO:0046087)3.52823323
77cytidine catabolic process (GO:0006216)3.52823323
78regulation of macrophage chemotaxis (GO:0010758)3.51425580
79dendritic cell chemotaxis (GO:0002407)3.50969660
80* platelet activation (GO:0030168)3.50658335
81negative regulation of bone mineralization (GO:0030502)3.50302104
82regulation of platelet activation (GO:0010543)3.48808487
83detection of external biotic stimulus (GO:0098581)3.48743130
84regulation of mast cell activation (GO:0033003)3.47927514
85negative regulation of response to food (GO:0032096)3.46878587
86negative regulation of appetite (GO:0032099)3.46878587
87regulation of antigen processing and presentation (GO:0002577)3.44066939
88immunoglobulin mediated immune response (GO:0016064)3.41965847
89T cell migration (GO:0072678)3.41545330
90positive regulation of mast cell degranulation (GO:0043306)3.39851362
91positive regulation of mast cell activation involved in immune response (GO:0033008)3.39851362
92negative regulation of T cell apoptotic process (GO:0070233)3.37900368
93regulation of T-helper 1 cell differentiation (GO:0045625)3.37660320
94positive regulation of leukocyte chemotaxis (GO:0002690)3.34751462
95positive regulation of leukocyte migration (GO:0002687)3.34682684
96regulation of lipoprotein metabolic process (GO:0050746)3.34607215
97purinergic receptor signaling pathway (GO:0035587)3.32814708
98macrophage chemotaxis (GO:0048246)3.32356178
99G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.31234775
100negative regulation of granulocyte differentiation (GO:0030853)3.29813920
101response to host immune response (GO:0052572)3.29446305
102response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.29446305
103positive regulation of Rho protein signal transduction (GO:0035025)3.27614890
104positive regulation of receptor recycling (GO:0001921)3.26949253
105fusion of sperm to egg plasma membrane (GO:0007342)3.25970239
106regulation of dendritic cell antigen processing and presentation (GO:0002604)3.25949017
107positive regulation of systemic arterial blood pressure (GO:0003084)3.25781957
108regulation of Golgi to plasma membrane protein transport (GO:0042996)3.25755573
109dendritic cell migration (GO:0036336)3.22527427
110myeloid leukocyte activation (GO:0002274)3.20786354
111cyclooxygenase pathway (GO:0019371)3.20559538
112positive regulation of coagulation (GO:0050820)3.18478348
113positive regulation of interleukin-1 beta secretion (GO:0050718)3.17962698
114positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.17942147
115negative regulation of protein localization to cell surface (GO:2000009)3.17707695
116termination of G-protein coupled receptor signaling pathway (GO:0038032)3.16816907
117regulation of tolerance induction (GO:0002643)3.16555297
118positive regulation of interferon-alpha production (GO:0032727)3.15060786
119termination of signal transduction (GO:0023021)3.14741441
120negative regulation of biomineral tissue development (GO:0070168)3.14662765
121* leukocyte chemotaxis (GO:0030595)3.13110211
122positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.11439094
123skeletal muscle tissue regeneration (GO:0043403)3.08246116
124hydrogen peroxide biosynthetic process (GO:0050665)3.05486605
125myeloid leukocyte migration (GO:0097529)3.04453863
126negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.03626128
127neutrophil chemotaxis (GO:0030593)3.03384581
128regulation of interferon-alpha production (GO:0032647)3.02967665
129lens fiber cell differentiation (GO:0070306)3.01233959
130autophagic vacuole fusion (GO:0000046)3.00844092
131leukocyte degranulation (GO:0043299)3.00824751
132regulation of leukocyte chemotaxis (GO:0002688)3.00395148
133regulation of female receptivity (GO:0045924)2.99924924
134positive regulation of B cell differentiation (GO:0045579)2.99544519
135regulation of mast cell degranulation (GO:0043304)2.99133885
136negative regulation of interleukin-12 production (GO:0032695)2.98447177
137regulation of inositol phosphate biosynthetic process (GO:0010919)2.98440842
138extracellular fibril organization (GO:0043206)2.98254588
139membrane invagination (GO:0010324)2.97604298
140superoxide anion generation (GO:0042554)2.97079063
141negative regulation of heart contraction (GO:0045822)2.96832634
142regulation of regulatory T cell differentiation (GO:0045589)2.96427719
143positive regulation of T-helper 1 type immune response (GO:0002827)2.96148058
144neutrophil migration (GO:1990266)2.94943077
145Arp2/3 complex-mediated actin nucleation (GO:0034314)2.94891501
146positive regulation of interleukin-1 secretion (GO:0050716)2.94474791
147regulation of clathrin-mediated endocytosis (GO:2000369)2.93866365
148response to muramyl dipeptide (GO:0032495)2.93122438
149response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.91779818
150response to host (GO:0075136)2.91779818
151response to host defenses (GO:0052200)2.91779818
152negative regulation of neural precursor cell proliferation (GO:2000178)2.91068838
153regulation of T-helper 2 cell differentiation (GO:0045628)2.91068436
154detection of biotic stimulus (GO:0009595)2.89278065
155negative regulation of calcium ion transport into cytosol (GO:0010523)2.88926973
156mast cell activation (GO:0045576)2.87875439
157pyrimidine nucleoside catabolic process (GO:0046135)2.86606362
158positive regulation of granulocyte differentiation (GO:0030854)2.86295537
159regulation of endothelial cell differentiation (GO:0045601)2.85736809
160positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.85233905
161negative regulation of cell killing (GO:0031342)2.83692532
162negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.83692532
163regulation of norepinephrine secretion (GO:0014061)2.83385023
164regulation of hemostasis (GO:1900046)2.83321693
165regulation of blood coagulation (GO:0030193)2.83321693
166cellular biogenic amine biosynthetic process (GO:0042401)2.83204138
167regulation of apoptotic cell clearance (GO:2000425)2.83147345
168regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)2.82505860
169regulation of interferon-beta biosynthetic process (GO:0045357)2.81435672
170regulation of mast cell activation involved in immune response (GO:0033006)2.81251185
171regulation of cholesterol storage (GO:0010885)2.80073556
172regulation of interleukin-1 beta secretion (GO:0050706)2.79323941
173G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.79121206
174positive regulation of B cell mediated immunity (GO:0002714)2.78440013
175positive regulation of immunoglobulin mediated immune response (GO:0002891)2.78440013
176beta-amyloid metabolic process (GO:0050435)2.77657923
177vesicle targeting (GO:0006903)2.76673307
178negative regulation of stress fiber assembly (GO:0051497)2.73818243
179long-chain fatty acid biosynthetic process (GO:0042759)2.72947301
180monoamine transport (GO:0015844)2.72440617
181regulation of myeloid leukocyte mediated immunity (GO:0002886)2.71076878
182positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.70970455
183positive regulation of gamma-delta T cell activation (GO:0046645)2.70877695
184regulation of thymocyte apoptotic process (GO:0070243)2.69921086

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse6.37056842
2* IRF8_27001747_Chip-Seq_BMDM_Mouse4.80028212
3SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.52579083
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.90371911
5NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.85474964
6Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.43706608
7* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.41638643
8SCL_19346495_ChIP-Seq_HPC-7_Human3.35418570
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.96636841
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.92023282
11NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.78774890
12MYB_21317192_ChIP-Seq_ERMYB_Mouse2.57657312
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.49194022
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.44097142
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.38544545
16SPI1_23547873_ChIP-Seq_NB4_Human2.26844587
17* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.21271828
18* LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.17847586
19PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse2.14800165
20RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.11484049
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.09998583
22EZH2_22144423_ChIP-Seq_EOC_Human2.09163543
23VDR_24787735_ChIP-Seq_THP-1_Human2.03031854
24BP1_19119308_ChIP-ChIP_Hs578T_Human11.3081405
25STAT4_19710469_ChIP-ChIP_TH1__Mouse1.98859219
26PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.95574705
27* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.89535793
28BRD4_27068464_Chip-Seq_AML-cells_Mouse1.86289896
29IKZF1_21737484_ChIP-ChIP_HCT116_Human1.85443075
30* RUNX1_22412390_ChIP-Seq_EML_Mouse1.78596625
31SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.76287361
32PU_27001747_Chip-Seq_BMDM_Mouse1.75772043
33EGR1_19032775_ChIP-ChIP_M12_Human1.73392834
34SRY_22984422_ChIP-ChIP_TESTIS_Rat1.71793384
35VDR_24763502_ChIP-Seq_THP-1_Human1.69076548
36IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.68824594
37ELK4_26923725_Chip-Seq_MESODERM_Mouse1.68137767
38CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.66985598
39RUNX_20019798_ChIP-Seq_JUKART_Human1.64801191
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63958702
41CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.60942104
42STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.59618046
43SPI1_23127762_ChIP-Seq_K562_Human1.58505849
44NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.58007862
45HTT_18923047_ChIP-ChIP_STHdh_Human1.56312226
46CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.55662736
47GBX2_23144817_ChIP-Seq_PC3_Human1.54478890
48GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.54230407
49CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.53410397
50GATA1_19941827_ChIP-Seq_MEL86_Mouse1.52472627
51PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.46934266
52* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.45316133
53GATA1_19941826_ChIP-Seq_K562_Human1.43166361
54RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38691010
55GATA2_21666600_ChIP-Seq_HMVEC_Human1.37522169
56* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.35401991
57PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29729217
58KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.24485938
59SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20950414
60* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.20203009
61* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.19751949
62THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.18222560
63ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.17338990
64PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.16093917
65EGR1_19374776_ChIP-ChIP_THP-1_Human1.13634397
66VDR_21846776_ChIP-Seq_THP-1_Human1.13463168
67FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.09844234
68SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08452643
69* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.08338795
70GATA2_22383799_ChIP-Seq_G1ME_Mouse1.08034064
71CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.06852704
72GATA2_19941826_ChIP-Seq_K562_Human1.03811869
73PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03678642
74MYB_26560356_Chip-Seq_TH2_Human1.02905796
75BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01846472
76NCOR1_26117541_ChIP-Seq_K562_Human1.01668055
77MAF_26560356_Chip-Seq_TH1_Human1.00766593
78SALL4_22934838_ChIP-ChIP_CD34+_Human0.97443305
79* SPI1_20517297_ChIP-Seq_HL60_Human0.96130193
80FOXM1_23109430_ChIP-Seq_U2OS_Human0.94631453
81GATA1_19941827_ChIP-Seq_MEL_Mouse0.94463221
82WT1_19549856_ChIP-ChIP_CCG9911_Human0.94035055
83* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.92366244
84STAT6_21828071_ChIP-Seq_BEAS2B_Human0.91928676
85MYB_26560356_Chip-Seq_TH1_Human0.88720403
86GATA3_26560356_Chip-Seq_TH2_Human0.86527334
87STAT1_20625510_ChIP-Seq_HELA_Human0.86403468
88GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86353507
89GATA1_22025678_ChIP-Seq_K562_Human0.86268177
90ESR1_20079471_ChIP-ChIP_T-47D_Human0.85884059
91SMRT_27268052_Chip-Seq_Bcells_Human0.84799062
92CDX2_19796622_ChIP-Seq_MESCs_Mouse0.84620509
93TAF15_26573619_Chip-Seq_HEK293_Human0.84372325
94CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.82690731
95EGR1_23403033_ChIP-Seq_LIVER_Mouse0.82565011
96OCT1_27270436_Chip-Seq_PROSTATE_Human0.80933436
97FOXO3_23340844_ChIP-Seq_DLD1_Human0.80839215
98GATA3_21878914_ChIP-Seq_MCF-7_Human0.79868359
99NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.77845953
100TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.77393709
101VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.77347879
102EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.76219465
103UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.74237847
104NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.74223434
105NRF2_20460467_ChIP-Seq_MEFs_Mouse0.74223434
106* LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.73801835
107E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.73470816
108GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71785227
109TCF4_18268006_ChIP-ChIP_LS174T_Human0.71489308
110CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.70989188
111SMAD_19615063_ChIP-ChIP_OVARY_Human0.70922846
112RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.70801283
113* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70698065
114CDX2_20551321_ChIP-Seq_CACO-2_Human0.69252714
115NANOG_20526341_ChIP-Seq_ESCs_Human0.68989841
116* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.68884318
117TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.65995793
118* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.65840713
119UTX_26944678_Chip-Seq_JUKART_Human0.64411358
120TRIM28_21343339_ChIP-Seq_HEK293_Human0.60557463
121CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.59453918
122ETS1_22383799_ChIP-Seq_G1ME_Mouse0.58830320
123EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.57855061
124TCF7_22412390_ChIP-Seq_EML_Mouse0.57491725
125HOXB4_20404135_ChIP-ChIP_EML_Mouse0.56645687
126GATA3_27048872_Chip-Seq_THYMUS_Human0.53376106
127FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.53026941
128CJUN_26792858_Chip-Seq_BT549_Human0.52184556
129P63_26484246_Chip-Seq_KERATINOCYTES_Human0.51967756
130ESR1_21235772_ChIP-Seq_MCF-7_Human0.48620359

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology4.68121723
2MP0002148_abnormal_hypersensitivity_rea4.45647324
3MP0003436_decreased_susceptibility_to4.07052958
4MP0001835_abnormal_antigen_presentation3.90435561
5MP0009840_abnormal_foam_cell3.70128460
6MP0002419_abnormal_innate_immunity3.38098926
7MP0005464_abnormal_platelet_physiology3.17818176
8MP0005000_abnormal_immune_tolerance3.11465658
9MP0000343_altered_response_to2.91385946
10MP0006082_CNS_inflammation2.81503911
11MP0005083_abnormal_biliary_tract2.78798058
12MP0005025_abnormal_response_to2.74817381
13MP0009785_altered_susceptibility_to2.59373270
14MP0003724_increased_susceptibility_to2.50349087
15MP0002452_abnormal_antigen_presenting2.47298473
16MP0005387_immune_system_phenotype2.42934423
17MP0001790_abnormal_immune_system2.42934423
18MP0001533_abnormal_skeleton_physiology2.41290247
19MP0002723_abnormal_immune_serum2.30100204
20MP0001800_abnormal_humoral_immune2.27058442
21MP0003303_peritoneal_inflammation2.18787566
22MP0005671_abnormal_response_to2.18545173
23MP0002736_abnormal_nociception_after2.16193636
24MP0002405_respiratory_system_inflammati2.14546487
25MP0000685_abnormal_immune_system2.05697072
26MP0005084_abnormal_gallbladder_morpholo2.01762794
27MP0002420_abnormal_adaptive_immunity2.01689172
28MP0003690_abnormal_glial_cell2.00677969
29MP0001819_abnormal_immune_cell1.99059009
30MP0003191_abnormal_cellular_cholesterol1.97845736
31MP0002638_abnormal_pupillary_reflex1.97696503
32MP0003566_abnormal_cell_adhesion1.94670844
33MP0000569_abnormal_digit_pigmentation1.83517686
34MP0001845_abnormal_inflammatory_respons1.81364722
35MP0003172_abnormal_lysosome_physiology1.81297321
36MP0000230_abnormal_systemic_arterial1.77595487
37MP0002132_abnormal_respiratory_system1.74194083
38MP0003075_altered_response_to1.73776852
39MP0004130_abnormal_muscle_cell1.71942381
40MP0006054_spinal_hemorrhage1.68381512
41MP0005174_abnormal_tail_pigmentation1.65351300
42MP0000604_amyloidosis1.63527432
43MP0004084_abnormal_cardiac_muscle1.61927617
44MP0001853_heart_inflammation1.61549863
45MP0010368_abnormal_lymphatic_system1.57408299
46MP0005167_abnormal_blood-brain_barrier1.54139955
47MP0009764_decreased_sensitivity_to1.53478611
48MP0003638_abnormal_response/metabolism_1.53300236
49MP0004510_myositis1.51245478
50MP0008469_abnormal_protein_level1.50797543
51MP0002998_abnormal_bone_remodeling1.48495044
52MP0001663_abnormal_digestive_system1.44733068
53MP0002254_reproductive_system_inflammat1.43815009
54MP0010155_abnormal_intestine_physiology1.43031536
55MP0005164_abnormal_response_to1.42679147
56MP0001968_abnormal_touch/_nociception1.39849122
57MP0002277_abnormal_respiratory_mucosa1.39296368
58MP0000716_abnormal_immune_system1.35295027
59MP0005310_abnormal_salivary_gland1.35158208
60MP0001727_abnormal_embryo_implantation1.35069671
61MP0003828_pulmonary_edema1.34389028
62MP0008872_abnormal_physiological_respon1.33770522
63MP0003866_abnormal_defecation1.32891591
64MP0000689_abnormal_spleen_morphology1.31305550
65MP0000015_abnormal_ear_pigmentation1.30017808
66MP0003879_abnormal_hair_cell1.29022230
67MP0000465_gastrointestinal_hemorrhage1.25364034
68MP0005410_abnormal_fertilization1.25136097
69MP0009333_abnormal_splenocyte_physiolog1.21811737
70MP0001879_abnormal_lymphatic_vessel1.20894031
71MP0003448_altered_tumor_morphology1.20163195
72MP0003279_aneurysm1.19829284
73MP0004036_abnormal_muscle_relaxation1.19356625
74MP0000249_abnormal_blood_vessel1.17023728
75MP0008775_abnormal_heart_ventricle1.16509613
76MP0003300_gastrointestinal_ulcer1.16109099
77* MP0002398_abnormal_bone_marrow1.14901207
78* MP0002429_abnormal_blood_cell1.14254460
79MP0004883_abnormal_blood_vessel1.13271549
80MP0005166_decreased_susceptibility_to1.10192175
81MP0002722_abnormal_immune_system1.09694788
82MP0009763_increased_sensitivity_to1.09679937
83MP0000920_abnormal_myelination1.07424272
84MP0005390_skeleton_phenotype1.05631611
85MP0003656_abnormal_erythrocyte_physiolo1.01867849
86MP0002653_abnormal_ependyma_morphology1.01114686
87MP0002733_abnormal_thermal_nociception0.98259413
88MP0008874_decreased_physiological_sensi0.97225526
89MP0001851_eye_inflammation0.97179447
90MP0004947_skin_inflammation0.96118621
91MP0005646_abnormal_pituitary_gland0.95247899
92MP0002006_tumorigenesis0.93287017
93MP0009765_abnormal_xenobiotic_induced0.92272321
94MP0003186_abnormal_redox_activity0.91398750
95MP0009278_abnormal_bone_marrow0.90831979
96MP0005409_darkened_coat_color0.89713309
97MP0002138_abnormal_hepatobiliary_system0.89384662
98MP0008438_abnormal_cutaneous_collagen0.89202871
99MP0005381_digestive/alimentary_phenotyp0.88416017
100MP0002396_abnormal_hematopoietic_system0.88240408
101MP0005397_hematopoietic_system_phenotyp0.86608571
102MP0001545_abnormal_hematopoietic_system0.86608571
103* MP0009642_abnormal_blood_homeostasis0.86136127
104MP0000703_abnormal_thymus_morphology0.86071837
105MP0003183_abnormal_peptide_metabolism0.85240967
106MP0000858_altered_metastatic_potential0.82025374
107MP0009697_abnormal_copulation0.80110162
108MP0003795_abnormal_bone_structure0.79974440
109MP0002095_abnormal_skin_pigmentation0.79458183
110MP0002136_abnormal_kidney_physiology0.78589798
111MP0002295_abnormal_pulmonary_circulatio0.78342205
112MP0001664_abnormal_digestion0.77071251
113MP0005165_increased_susceptibility_to0.76275038
114MP0000490_abnormal_crypts_of0.75267884
115MP0000767_abnormal_smooth_muscle0.74236432
116MP0008260_abnormal_autophagy0.74065658
117MP0004782_abnormal_surfactant_physiolog0.72403804
118MP0001970_abnormal_pain_threshold0.72401232
119MP0001765_abnormal_ion_homeostasis0.70750545
120MP0005197_abnormal_uvea_morphology0.69273857
121MP0004381_abnormal_hair_follicle0.68019397
122MP0008873_increased_physiological_sensi0.67629740
123MP0004484_altered_response_of0.66875236
124MP0005535_abnormal_body_temperature0.66518341
125MP0001915_intracranial_hemorrhage0.66422076
126MP0004808_abnormal_hematopoietic_stem0.65643107
127MP0005408_hypopigmentation0.64546772
128MP0002090_abnormal_vision0.63308922
129MP0005023_abnormal_wound_healing0.62871765
130MP0006276_abnormal_autonomic_nervous0.62810552
131MP0003763_abnormal_thymus_physiology0.62370151
132MP0003011_delayed_dark_adaptation0.62186776
133MP0005365_abnormal_bile_salt0.61420738
134MP0002118_abnormal_lipid_homeostasis0.61331002
135MP0000609_abnormal_liver_physiology0.60938386
136MP0000371_diluted_coat_color0.60343898
137MP0004147_increased_porphyrin_level0.60204883
138MP0005085_abnormal_gallbladder_physiolo0.59319874
139MP0002933_joint_inflammation0.59157900
140MP0008004_abnormal_stomach_pH0.58752847
141MP0004019_abnormal_vitamin_homeostasis0.58590303
142MP0010329_abnormal_lipoprotein_level0.58542496

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)8.30862198
2Recurrent abscess formation (HP:0002722)7.40986468
3Glomerulonephritis (HP:0000099)6.53772820
4Recurrent bacterial skin infections (HP:0005406)6.49410978
5Eczematoid dermatitis (HP:0000976)5.53708989
6Hyperlipoproteinemia (HP:0010980)5.34252804
7Vacuolated lymphocytes (HP:0001922)5.25915966
8Axonal loss (HP:0003447)5.14251962
9Agnosia (HP:0010524)5.01358316
10Abnormality of complement system (HP:0005339)4.94327412
11Disinhibition (HP:0000734)4.88071484
12Complement deficiency (HP:0004431)4.86487901
13Recurrent gram-negative bacterial infections (HP:0005420)4.67389309
14Prostate neoplasm (HP:0100787)4.62912098
15Increased neuronal autofluorescent lipopigment (HP:0002074)4.61862848
16Spontaneous hematomas (HP:0007420)4.60365776
17Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)4.37489185
18Increased cerebral lipofuscin (HP:0011813)4.32973091
19Petechiae (HP:0000967)4.27486266
20Joint hemorrhage (HP:0005261)4.09016560
21Poikilocytosis (HP:0004447)3.96679426
22Prolonged bleeding time (HP:0003010)3.93086039
23Acanthocytosis (HP:0001927)3.76125143
24Dysostosis multiplex (HP:0000943)3.73745645
25Purpura (HP:0000979)3.70265220
26Nephritis (HP:0000123)3.69311701
27Abnormality of macrophages (HP:0004311)3.69185475
28Mediastinal lymphadenopathy (HP:0100721)3.58087082
29Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.54907692
30Recurrent skin infections (HP:0001581)3.51849263
31Dyschromatopsia (HP:0007641)3.45047848
32Bruising susceptibility (HP:0000978)3.43145640
33Upper motor neuron abnormality (HP:0002127)3.34127619
34Increased density of long bones (HP:0006392)3.31472390
35Abnormality of the heme biosynthetic pathway (HP:0010472)3.30140112
36Obstructive lung disease (HP:0006536)3.29453111
37Chronic obstructive pulmonary disease (HP:0006510)3.29453111
38Menorrhagia (HP:0000132)3.27461087
39Basal ganglia calcification (HP:0002135)3.22960093
40Abnormality of the prostate (HP:0008775)3.18546127
41Gingivitis (HP:0000230)3.15284792
42Epistaxis (HP:0000421)3.10916717
43Pathologic fracture (HP:0002756)3.04478640
44Large eyes (HP:0001090)3.02941739
45Abnormal pupillary function (HP:0007686)3.02849111
46Abnormality of lateral ventricle (HP:0030047)2.92701199
47Paralysis (HP:0003470)2.88237059
48Thick nail (HP:0001805)2.81658951
49Abnormality of the common coagulation pathway (HP:0010990)2.81046749
50Abnormality of the vasculature of the conjunctiva (HP:0008054)2.77798827
51Cellulitis (HP:0100658)2.76922727
52Abnormal platelet volume (HP:0011876)2.76365205
53Stomatitis (HP:0010280)2.67710477
54Gingival bleeding (HP:0000225)2.67256512
55Inappropriate behavior (HP:0000719)2.59875086
56Recurrent viral infections (HP:0004429)2.57911281
57Increased IgM level (HP:0003496)2.53753357
58Pustule (HP:0200039)2.52003058
59Recurrent fungal infections (HP:0002841)2.48665198
60Periodontitis (HP:0000704)2.46130899
61Joint swelling (HP:0001386)2.45386463
62Urticaria (HP:0001025)2.44613988
63Panhypogammaglobulinemia (HP:0003139)2.43351491
64Conjunctival telangiectasia (HP:0000524)2.41988664
65Encephalitis (HP:0002383)2.41037807
66Colitis (HP:0002583)2.38165781
67Decreased central vision (HP:0007663)2.37011232
68Abnormal number of erythroid precursors (HP:0012131)2.36757076
69Progressive visual loss (HP:0000529)2.36633329
70Arterial thrombosis (HP:0004420)2.34423015
71Tinnitus (HP:0000360)2.33192935
72Increased mean platelet volume (HP:0011877)2.31640373
73Inflammation of the large intestine (HP:0002037)2.28778475
74Hematochezia (HP:0002573)2.24707851
75Hypokinesia (HP:0002375)2.23961294
76Neurofibrillary tangles (HP:0002185)2.23815600
77Osteolytic defects of the hand bones (HP:0009699)2.23810668
78Osteolytic defects of the phalanges of the hand (HP:0009771)2.23810668
79Bone cyst (HP:0012062)2.23796601
80Abnormality of glycolipid metabolism (HP:0010969)2.22439408
81Abnormality of liposaccharide metabolism (HP:0010968)2.22439408
82Abnormality of glycosphingolipid metabolism (HP:0004343)2.22439408
83Myocardial infarction (HP:0001658)2.21719219
84Personality changes (HP:0000751)2.21309003
85Meningitis (HP:0001287)2.21296118
86Episodic fever (HP:0001954)2.18187550
87Abnormality of cells of the erythroid lineage (HP:0012130)2.18117999
88Urinary glycosaminoglycan excretion (HP:0003541)2.16162730
89Mucopolysacchariduria (HP:0008155)2.16162730
90Bone pain (HP:0002653)2.16125971
91Abnormal auditory evoked potentials (HP:0006958)2.15986304
92Xanthomatosis (HP:0000991)2.15694953
93Osteomyelitis (HP:0002754)2.14473659
94Dysautonomia (HP:0002459)2.10864421
95Myositis (HP:0100614)2.10599220
96Chest pain (HP:0100749)2.09011510
97Peripheral demyelination (HP:0011096)2.08238558
98Aplasia cutis congenita (HP:0001057)2.07407804
99Apathy (HP:0000741)2.06431518
100Gastrointestinal inflammation (HP:0004386)2.06019531
101Polycythemia (HP:0001901)2.05433551
102Abnormality of transition element cation homeostasis (HP:0011030)2.03632515
103Hepatosplenomegaly (HP:0001433)2.01532555
104Ventricular fibrillation (HP:0001663)1.97356116
105Orchitis (HP:0100796)1.97290261
106Diminished motivation (HP:0000745)1.96684672
107Upper limb muscle weakness (HP:0003484)1.96405498
108Elevated erythrocyte sedimentation rate (HP:0003565)1.93997253
109Autoimmune hemolytic anemia (HP:0001890)1.93533316
110Optic neuritis (HP:0100653)1.91788132
111Retrobulbar optic neuritis (HP:0100654)1.91788132
112Vertigo (HP:0002321)1.89662374
113Sepsis (HP:0100806)1.89299328
114Generalized aminoaciduria (HP:0002909)1.88765974
115Agammaglobulinemia (HP:0004432)1.88525227
116Abnormality of mucopolysaccharide metabolism (HP:0011020)1.87100992
117Abnormality of polysaccharide metabolism (HP:0011012)1.87100992
118Abnormality of glycosaminoglycan metabolism (HP:0004371)1.87100992
119Chronic otitis media (HP:0000389)1.86372560
120Nausea (HP:0002018)1.82605582
121Interstitial pulmonary disease (HP:0006530)1.82113255
122Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.82038254
123Recurrent pneumonia (HP:0006532)1.81493627
124Absent/shortened dynein arms (HP:0200106)1.77400744
125Dynein arm defect of respiratory motile cilia (HP:0012255)1.77400744
126Spontaneous abortion (HP:0005268)1.76878354
127Leukocytosis (HP:0001974)1.76005416
128Abnormality of iron homeostasis (HP:0011031)1.75924735
129Papillary thyroid carcinoma (HP:0002895)1.74522778
130Increased serum ferritin (HP:0003281)1.72361570
131Abnormal platelet function (HP:0011869)1.71956928
132Impaired platelet aggregation (HP:0003540)1.71956928
133Abnormality of male internal genitalia (HP:0000022)1.71030206
134Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.70659295
135Autoimmune thrombocytopenia (HP:0001973)1.70267869
136Abnormal ciliary motility (HP:0012262)1.70036962
137Hyperthyroidism (HP:0000836)1.68442253
138Thrombophlebitis (HP:0004418)1.62463051
139Diplopia (HP:0000651)1.62014565
140Abnormality of binocular vision (HP:0011514)1.62014565
141Male infertility (HP:0003251)1.61546937
142Thyroid-stimulating hormone excess (HP:0002925)1.58371339
143Hypochromic microcytic anemia (HP:0004840)1.56066075
144Granulocytopenia (HP:0001913)1.55468232
145Keratoconjunctivitis sicca (HP:0001097)1.54942148
146Muscle fibrillation (HP:0010546)1.53359502
147Eosinophilia (HP:0001880)1.52023081
148Pulmonary embolism (HP:0002204)1.51647319
149Vasculitis (HP:0002633)1.48161033
150Uterine leiomyosarcoma (HP:0002891)1.46487363
151Leiomyosarcoma (HP:0100243)1.46487363
152Amaurosis fugax (HP:0100576)1.46411409
153Hypophosphatemic rickets (HP:0004912)1.46310688
154Microcytic anemia (HP:0001935)1.46292184
155Mucosal telangiectasiae (HP:0100579)1.44062822
156Transitional cell carcinoma of the bladder (HP:0006740)1.43536293
157Abnormal respiratory epithelium morphology (HP:0012253)1.43398743
158Abnormal respiratory motile cilium morphology (HP:0005938)1.43398743
159Distal lower limb amyotrophy (HP:0008944)1.43304995
160Biliary tract neoplasm (HP:0100574)1.42019601
161Arthralgia (HP:0002829)1.41242667

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK8.37610581
2MST44.94203935
3RIPK43.54265766
4EIF2AK12.82249130
5TGFBR22.65536638
6TYK22.64235564
7MAP3K142.62043480
8IRAK32.29147256
9GRK72.13991504
10IRAK42.10301888
11TEC2.05812118
12BMPR1B2.00748050
13BTK1.97971440
14TXK1.91628914
15LYN1.63390840
16ILK1.60156921
17MAP4K11.54703654
18MAP3K101.51461959
19SYK1.45501784
20DMPK1.45110376
21YES11.44950884
22PIM21.37177143
23PBK1.35771930
24IKBKB1.34608642
25STK31.33003039
26TGFBR11.32283099
27CLK11.30226546
28STK101.21138323
29MAP3K121.20020097
30TBK11.19342864
31NME21.18703649
32HCK1.17796560
33CSF1R1.17629826
34EPHB21.17117496
35LCK1.15018899
36KIT1.13412697
37SCYL21.11579376
38PAK11.10757269
39TAOK31.08075366
40MAPKAPK31.06360198
41PIK3CG1.06018092
42ITK1.04159706
43ZAP701.03047787
44LMTK21.01637830
45PLK21.01257591
46BMPR20.97945124
47CSK0.97436365
48PAK40.97059154
49EPHB10.94933335
50IKBKE0.93965205
51PIM10.93772394
52SIK30.93492439
53TAOK10.91002962
54TNK20.89695047
55MARK30.89050407
56TAOK20.88765959
57ACVR1B0.87097466
58STK240.86771024
59MAPK120.85338360
60IRAK10.85282131
61EIF2AK20.84282373
62JAK10.83814538
63ARAF0.83294213
64MATK0.77970366
65FES0.77776136
66PRKCD0.76886046
67PDK10.76820765
68MAP3K50.75486732
69JAK20.75361306
70MST1R0.74784268
71IGF1R0.74274060
72FGR0.71847895
73ERBB20.71722261
74MAP2K30.69138386
75EPHA30.68501540
76ADRBK20.67945059
77PKN10.67710554
78TRPM70.66428351
79ABL20.66328327
80EGFR0.64401531
81RET0.64085492
82TESK20.63324728
83STK40.61848375
84KDR0.61803530
85TNIK0.60914276
86MKNK20.60558022
87PDPK10.60179987
88DAPK20.60064466
89MAP3K110.57766423
90MAPKAPK50.56982435
91CHUK0.55761854
92CDK60.54955980
93MOS0.53467598
94BMX0.53420167
95FER0.51664492
96MELK0.51224483
97MAP2K10.50812312
98NUAK10.50642451
99PRKACG0.50595850
100FYN0.47650603
101PRKCQ0.47102189
102PDGFRB0.46071659
103CAMKK20.44519268
104ADRBK10.44466248
105MKNK10.43835231
106GRK50.42846613
107JAK30.39659214
108ABL10.38754678
109NEK90.37382764
110DAPK30.36763198
111CDK80.35923654
112MAPKAPK20.35167207
113HIPK20.35081540
114LRRK20.34393272
115NLK0.34107474
116TRIM280.33264968
117MYLK0.32162243
118MAP3K30.32125729
119CAMKK10.31512348
120MAP2K20.31473601
121PAK30.31329875
122PRKD10.31289151
123PNCK0.31179021
124IRAK20.30964181
125CAMK1D0.30885544
126MAP3K10.30618039
127GRK10.30354450
128INSRR0.29525444
129RAF10.29000594
130PRKCB0.28458829
131TLK10.28153749
132DAPK10.26639229
133MAPK40.25958593
134GRK60.25563111
135RPS6KA40.25297722
136PRKG10.25044674
137SRC0.24909329
138DYRK1B0.24135956
139PTK2B0.23519218
140PRKCA0.23319794
141MAPK130.22896638
142RPS6KA60.22742831
143TTN0.22310212
144MINK10.21500276

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051506.44740357
2Leishmaniasis_Homo sapiens_hsa051402.97073195
3Pertussis_Homo sapiens_hsa051332.92306174
4Complement and coagulation cascades_Homo sapiens_hsa046102.81397893
5Other glycan degradation_Homo sapiens_hsa005112.64632893
6Osteoclast differentiation_Homo sapiens_hsa043802.60902302
7Lysosome_Homo sapiens_hsa041422.48009411
8Toll-like receptor signaling pathway_Homo sapiens_hsa046202.42385355
9Graft-versus-host disease_Homo sapiens_hsa053322.40994433
10Legionellosis_Homo sapiens_hsa051342.29804399
11Rheumatoid arthritis_Homo sapiens_hsa053232.24726213
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.24211174
13Tuberculosis_Homo sapiens_hsa051522.19675890
14Salmonella infection_Homo sapiens_hsa051322.17435690
15Phagosome_Homo sapiens_hsa041452.12652622
16Allograft rejection_Homo sapiens_hsa053302.08024281
17NOD-like receptor signaling pathway_Homo sapiens_hsa046212.05226578
18Malaria_Homo sapiens_hsa051442.02170723
19Hematopoietic cell lineage_Homo sapiens_hsa046401.99798500
20Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.79096893
21* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.77882771
22NF-kappa B signaling pathway_Homo sapiens_hsa040641.72648177
23Prion diseases_Homo sapiens_hsa050201.71307364
24Type I diabetes mellitus_Homo sapiens_hsa049401.69107858
25Nitrogen metabolism_Homo sapiens_hsa009101.65171213
26* Chemokine signaling pathway_Homo sapiens_hsa040621.64626800
27Gap junction_Homo sapiens_hsa045401.64406163
28Glycosaminoglycan degradation_Homo sapiens_hsa005311.56486264
29Intestinal immune network for IgA production_Homo sapiens_hsa046721.56149565
30Asthma_Homo sapiens_hsa053101.54051707
31Vascular smooth muscle contraction_Homo sapiens_hsa042701.50602040
32Measles_Homo sapiens_hsa051621.47393635
33Collecting duct acid secretion_Homo sapiens_hsa049661.46282599
34Serotonergic synapse_Homo sapiens_hsa047261.43100975
35B cell receptor signaling pathway_Homo sapiens_hsa046621.42115070
36Toxoplasmosis_Homo sapiens_hsa051451.30379510
37Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.27879599
38Arachidonic acid metabolism_Homo sapiens_hsa005901.26066150
39Platelet activation_Homo sapiens_hsa046111.24449236
40Olfactory transduction_Homo sapiens_hsa047401.20637988
41Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.18583311
42Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.18134545
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.10731171
44Alcoholism_Homo sapiens_hsa050341.07217867
45Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.06257682
46Shigellosis_Homo sapiens_hsa051311.05307298
47Sulfur metabolism_Homo sapiens_hsa009201.04220159
48Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.04105797
49Phospholipase D signaling pathway_Homo sapiens_hsa040721.03290201
50Ribosome_Homo sapiens_hsa030101.02209126
51Glycerolipid metabolism_Homo sapiens_hsa005611.02176666
52RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.97508945
53Influenza A_Homo sapiens_hsa051640.95525231
54African trypanosomiasis_Homo sapiens_hsa051430.95368717
55Amoebiasis_Homo sapiens_hsa051460.93378057
56Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.93265105
57Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.92414442
58AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.90825941
59Long-term depression_Homo sapiens_hsa047300.90619250
60Jak-STAT signaling pathway_Homo sapiens_hsa046300.90045674
61Herpes simplex infection_Homo sapiens_hsa051680.89719728
62Primary immunodeficiency_Homo sapiens_hsa053400.86796134
63Circadian entrainment_Homo sapiens_hsa047130.85993321
64TNF signaling pathway_Homo sapiens_hsa046680.84577795
65Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.84426565
66Morphine addiction_Homo sapiens_hsa050320.82692884
67Linoleic acid metabolism_Homo sapiens_hsa005910.80838086
68Rap1 signaling pathway_Homo sapiens_hsa040150.80721611
69Autoimmune thyroid disease_Homo sapiens_hsa053200.79385177
70Antigen processing and presentation_Homo sapiens_hsa046120.78038408
71Apoptosis_Homo sapiens_hsa042100.77686418
72Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75235496
73Leukocyte transendothelial migration_Homo sapiens_hsa046700.75214719
74Choline metabolism in cancer_Homo sapiens_hsa052310.75138866
75Non-small cell lung cancer_Homo sapiens_hsa052230.74382753
76Glycerophospholipid metabolism_Homo sapiens_hsa005640.71048424
77Pentose and glucuronate interconversions_Homo sapiens_hsa000400.70475245
78Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.69353023
79Viral myocarditis_Homo sapiens_hsa054160.67888700
80Mineral absorption_Homo sapiens_hsa049780.66768431
81Sphingolipid metabolism_Homo sapiens_hsa006000.66595215
82Systemic lupus erythematosus_Homo sapiens_hsa053220.63172765
83Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62170895
84Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61575535
85Ras signaling pathway_Homo sapiens_hsa040140.60679142
86Gastric acid secretion_Homo sapiens_hsa049710.59932728
87Endocytosis_Homo sapiens_hsa041440.59023029
88Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57292564
89Viral carcinogenesis_Homo sapiens_hsa052030.54679654
90Endometrial cancer_Homo sapiens_hsa052130.54234016
91Calcium signaling pathway_Homo sapiens_hsa040200.53857684
92Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53463579
93Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.52076263
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50207360
95ABC transporters_Homo sapiens_hsa020100.50045658
96Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.49788686
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.49295569
98Cholinergic synapse_Homo sapiens_hsa047250.48476410
99VEGF signaling pathway_Homo sapiens_hsa043700.47179460
100Dilated cardiomyopathy_Homo sapiens_hsa054140.45803782
101Renin secretion_Homo sapiens_hsa049240.45614812
102Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45601227
103Acute myeloid leukemia_Homo sapiens_hsa052210.45221336
104Glutathione metabolism_Homo sapiens_hsa004800.44719829
105GABAergic synapse_Homo sapiens_hsa047270.43823362
106cGMP-PKG signaling pathway_Homo sapiens_hsa040220.42595458
107Steroid hormone biosynthesis_Homo sapiens_hsa001400.41892035
108Ether lipid metabolism_Homo sapiens_hsa005650.41220930
109Fat digestion and absorption_Homo sapiens_hsa049750.41195709
110Renal cell carcinoma_Homo sapiens_hsa052110.40963702
111Regulation of actin cytoskeleton_Homo sapiens_hsa048100.40916741
112Pancreatic cancer_Homo sapiens_hsa052120.39179924
113Caffeine metabolism_Homo sapiens_hsa002320.35007432
114ECM-receptor interaction_Homo sapiens_hsa045120.34440757
115Hepatitis B_Homo sapiens_hsa051610.32735324
116Neurotrophin signaling pathway_Homo sapiens_hsa047220.31648684
117T cell receptor signaling pathway_Homo sapiens_hsa046600.30782101
118SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28542541
119Chronic myeloid leukemia_Homo sapiens_hsa052200.26406813
120Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.24777745
121Sphingolipid signaling pathway_Homo sapiens_hsa040710.24292785
122Hepatitis C_Homo sapiens_hsa051600.23291086
123N-Glycan biosynthesis_Homo sapiens_hsa005100.21462362
124Renin-angiotensin system_Homo sapiens_hsa046140.20178002
125Chemical carcinogenesis_Homo sapiens_hsa052040.19977540
126Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.19828969
127Small cell lung cancer_Homo sapiens_hsa052220.19514423
128Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.19348689
129Histidine metabolism_Homo sapiens_hsa003400.18883204
130Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.16647226
131Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.15906219
132HIF-1 signaling pathway_Homo sapiens_hsa040660.12112177
133Starch and sucrose metabolism_Homo sapiens_hsa005000.11749673
134Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.11706796
135Focal adhesion_Homo sapiens_hsa045100.08382740
136Proteoglycans in cancer_Homo sapiens_hsa052050.07964098
137Pancreatic secretion_Homo sapiens_hsa049720.07656211
138Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.07543984
139Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.06934447
140Adherens junction_Homo sapiens_hsa045200.06308056
141Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.05435848

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