PEX5L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)5.53985059
2central nervous system myelination (GO:0022010)5.53985059
3synaptic vesicle maturation (GO:0016188)5.47035575
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.22524602
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.93319865
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.83936814
7glutamate secretion (GO:0014047)4.60781553
8neuronal action potential propagation (GO:0019227)4.56537108
9L-amino acid import (GO:0043092)4.47603572
10locomotory exploration behavior (GO:0035641)4.47245358
11synaptic vesicle exocytosis (GO:0016079)4.44258915
12cerebellar granule cell differentiation (GO:0021707)4.38032113
13regulation of synaptic vesicle exocytosis (GO:2000300)4.33293404
14ionotropic glutamate receptor signaling pathway (GO:0035235)4.26412350
15postsynaptic membrane organization (GO:0001941)4.21786141
16cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.13774435
17vocalization behavior (GO:0071625)4.06496584
18protein localization to synapse (GO:0035418)4.05788835
19positive regulation of synapse maturation (GO:0090129)4.03397531
20neuron cell-cell adhesion (GO:0007158)4.01015936
21regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.92219777
22synaptic vesicle docking involved in exocytosis (GO:0016081)3.91939635
23regulation of neuronal synaptic plasticity (GO:0048168)3.91166910
24regulation of synaptic vesicle transport (GO:1902803)3.86826953
25synaptic transmission, glutamatergic (GO:0035249)3.83944269
26cellular potassium ion homeostasis (GO:0030007)3.81048601
27glycine transport (GO:0015816)3.80702830
28regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.73037981
29neuron-neuron synaptic transmission (GO:0007270)3.69705902
30glutamate receptor signaling pathway (GO:0007215)3.69044649
31regulation of long-term neuronal synaptic plasticity (GO:0048169)3.66477684
32regulation of glutamate receptor signaling pathway (GO:1900449)3.64708642
33negative regulation of dendrite morphogenesis (GO:0050774)3.61274940
34positive regulation of dendritic spine development (GO:0060999)3.56336036
35membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.54425564
36proline transport (GO:0015824)3.51966443
37dendritic spine morphogenesis (GO:0060997)3.50106411
38neurotransmitter secretion (GO:0007269)3.49617988
39cellular sodium ion homeostasis (GO:0006883)3.47419985
40cell communication by electrical coupling (GO:0010644)3.47366786
41transmission of nerve impulse (GO:0019226)3.46975453
42neuron recognition (GO:0008038)3.45395124
43gamma-aminobutyric acid transport (GO:0015812)3.44700436
44neurotransmitter uptake (GO:0001504)3.43315752
45long-term memory (GO:0007616)3.42108481
46adult walking behavior (GO:0007628)3.41314964
47regulation of excitatory postsynaptic membrane potential (GO:0060079)3.39970804
48exploration behavior (GO:0035640)3.37755049
49serotonin metabolic process (GO:0042428)3.37035011
50positive regulation of membrane potential (GO:0045838)3.35230073
51regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.34575874
52presynaptic membrane organization (GO:0097090)3.32485914
53amino acid import (GO:0043090)3.32301094
54neuromuscular synaptic transmission (GO:0007274)3.30549677
55positive regulation of neurotransmitter secretion (GO:0001956)3.29606051
56sodium ion export (GO:0071436)3.28596844
57phosphorelay signal transduction system (GO:0000160)3.28260785
58acidic amino acid transport (GO:0015800)3.26309026
59neurotransmitter transport (GO:0006836)3.25733411
60regulation of postsynaptic membrane potential (GO:0060078)3.25284322
61regulation of rhodopsin mediated signaling pathway (GO:0022400)3.23272874
62neuronal ion channel clustering (GO:0045161)3.21684300
63presynaptic membrane assembly (GO:0097105)3.21398857
64regulation of synapse maturation (GO:0090128)3.21282015
65regulation of dendritic spine development (GO:0060998)3.21041947
66negative regulation of synaptic transmission, GABAergic (GO:0032229)3.20050969
67synaptic transmission (GO:0007268)3.19797023
68rhodopsin mediated signaling pathway (GO:0016056)3.17855343
69myelination (GO:0042552)3.17290964
70regulation of synaptic plasticity (GO:0048167)3.17046783
71neuromuscular process controlling posture (GO:0050884)3.16847822
72layer formation in cerebral cortex (GO:0021819)3.15840255
73axon ensheathment (GO:0008366)3.15059931
74ensheathment of neurons (GO:0007272)3.15059931
75detection of calcium ion (GO:0005513)3.14502399
76regulation of ARF protein signal transduction (GO:0032012)3.14283983
77potassium ion import (GO:0010107)3.14261684
78cell differentiation in hindbrain (GO:0021533)3.13624952
79chemosensory behavior (GO:0007635)3.13204170
80regulation of voltage-gated calcium channel activity (GO:1901385)3.12545891
81regulation of synaptic transmission (GO:0050804)3.12170989
82positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.11829755
83membrane hyperpolarization (GO:0060081)3.10764850
84gamma-aminobutyric acid signaling pathway (GO:0007214)3.10301531
85negative regulation of neurotransmitter transport (GO:0051589)3.07483446
86axonal fasciculation (GO:0007413)3.07073472
87cerebellar Purkinje cell differentiation (GO:0021702)3.06442078
88regulation of synapse structural plasticity (GO:0051823)3.03960571
89regulation of neurotransmitter secretion (GO:0046928)3.02666806
90primary amino compound metabolic process (GO:1901160)3.01867422
91long-term synaptic potentiation (GO:0060291)3.01554250
92regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.00822898
93regulation of dendritic spine morphogenesis (GO:0061001)3.00011165
94neuromuscular process controlling balance (GO:0050885)2.99922321
95synaptic vesicle endocytosis (GO:0048488)2.99453748
96negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.98584906
97potassium ion homeostasis (GO:0055075)2.96786529
98positive regulation of dendritic spine morphogenesis (GO:0061003)2.94457903
99cell communication involved in cardiac conduction (GO:0086065)2.94275061
100establishment of synaptic vesicle localization (GO:0097480)2.92810337
101synaptic vesicle transport (GO:0048489)2.92810337
102neurotransmitter-gated ion channel clustering (GO:0072578)2.92335289
103regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.92018411
104regulation of vesicle fusion (GO:0031338)2.90399430
105vesicle transport along microtubule (GO:0047496)2.89757970
106startle response (GO:0001964)2.89398380
107dendrite morphogenesis (GO:0048813)2.89287029
108establishment of mitochondrion localization (GO:0051654)2.88180614
109long-chain fatty acid biosynthetic process (GO:0042759)2.86324476
110membrane depolarization (GO:0051899)2.86079271
111membrane depolarization during action potential (GO:0086010)2.85104738
112regulation of neurotransmitter levels (GO:0001505)2.84499870
113regulation of neurotransmitter transport (GO:0051588)2.83690644
114positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.81311661
115positive regulation of neurotransmitter transport (GO:0051590)2.79075641
116eye photoreceptor cell differentiation (GO:0001754)2.78682421
117photoreceptor cell differentiation (GO:0046530)2.78682421
118nerve growth factor signaling pathway (GO:0038180)2.78432027
119negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.78017781
120organelle transport along microtubule (GO:0072384)2.77329756
121regulation of synaptic transmission, glutamatergic (GO:0051966)2.77027968
122dendritic spine organization (GO:0097061)2.75684529
123innervation (GO:0060384)2.75158508
124positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.73536526
125peptidyl-tyrosine autophosphorylation (GO:0038083)2.72676686
126neuromuscular process (GO:0050905)2.71825635
127negative regulation of neurotransmitter secretion (GO:0046929)2.71355668
128auditory behavior (GO:0031223)2.70536127

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.09007989
2GBX2_23144817_ChIP-Seq_PC3_Human3.61812201
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.87848249
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.82089816
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.73508953
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.50366983
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.50366983
8SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.42636590
9* DROSHA_22980978_ChIP-Seq_HELA_Human2.42507079
10MTF2_20144788_ChIP-Seq_MESCs_Mouse2.42080375
11RARB_27405468_Chip-Seq_BRAIN_Mouse2.37043296
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.36467040
13* REST_21632747_ChIP-Seq_MESCs_Mouse2.35979827
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.33535167
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.29957950
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.23930768
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.22811239
18SUZ12_27294783_Chip-Seq_ESCs_Mouse2.14921841
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.11993397
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.06582877
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.00945248
22REST_18959480_ChIP-ChIP_MESCs_Mouse1.91750084
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.91220045
24AR_21572438_ChIP-Seq_LNCaP_Human1.79998273
25RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.70267426
26IKZF1_21737484_ChIP-ChIP_HCT116_Human1.68300910
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.62531262
28SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61673286
29TAF15_26573619_Chip-Seq_HEK293_Human1.61047803
30SMAD4_21799915_ChIP-Seq_A2780_Human1.56986087
31SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.56488130
32MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.55488098
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.50785118
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.49166020
35EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.45787753
36* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.44810939
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.44665964
38OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41973160
39* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40652662
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39016825
41SMAD3_21741376_ChIP-Seq_EPCs_Human1.36882936
42* P300_19829295_ChIP-Seq_ESCs_Human1.32659244
43* STAT3_23295773_ChIP-Seq_U87_Human1.32260642
44SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31384683
45TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30162687
46PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.29947277
47RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.29111002
48NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.25626215
49ERG_21242973_ChIP-ChIP_JURKAT_Human1.24328917
50PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.23479102
51CDX2_19796622_ChIP-Seq_MESCs_Mouse1.21832258
52* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.21601880
53RING1B_27294783_Chip-Seq_ESCs_Mouse1.20819369
54CTNNB1_20460455_ChIP-Seq_HCT116_Human1.20514337
55VDR_22108803_ChIP-Seq_LS180_Human1.20323794
56VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.19881736
57CBX2_27304074_Chip-Seq_ESCs_Mouse1.18813247
58SOX2_21211035_ChIP-Seq_LN229_Gbm1.16673563
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.16326020
60* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.14827597
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13919477
62TCF4_23295773_ChIP-Seq_U87_Human1.12519401
63P53_22127205_ChIP-Seq_FIBROBLAST_Human1.11684336
64POU3F2_20337985_ChIP-ChIP_501MEL_Human1.10661663
65* AR_19668381_ChIP-Seq_PC3_Human1.09790645
66ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09665429
67POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09630306
68TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09630306
69* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.09195989
70AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09117077
71IGF1R_20145208_ChIP-Seq_DFB_Human1.08899956
72* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08459435
73ARNT_22903824_ChIP-Seq_MCF-7_Human1.08263624
74SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.07953429
75RING1B_27294783_Chip-Seq_NPCs_Mouse1.07436906
76AR_25329375_ChIP-Seq_VCAP_Human1.07250575
77AHR_22903824_ChIP-Seq_MCF-7_Human1.05440645
78CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.05377628
79TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04890816
80THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.04579211
81PRDM14_20953172_ChIP-Seq_ESCs_Human1.04279916
82BMI1_23680149_ChIP-Seq_NPCS_Mouse1.04195307
83GATA1_26923725_Chip-Seq_HPCs_Mouse1.04130103
84LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03294208
85MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00505313
86NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00320405
87SMAD_19615063_ChIP-ChIP_OVARY_Human1.00278602
88* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00083505
89ER_23166858_ChIP-Seq_MCF-7_Human0.99918104
90ZNF274_21170338_ChIP-Seq_K562_Hela0.99058261
91* NANOG_18555785_Chip-Seq_ESCs_Mouse0.97294345
92TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.96660137
93SOX9_26525672_Chip-Seq_HEART_Mouse0.95964312
94TP53_16413492_ChIP-PET_HCT116_Human0.95901344
95SMAD3_21741376_ChIP-Seq_HESCs_Human0.94259156
96RUNX2_22187159_ChIP-Seq_PCA_Human0.94207242
97KDM2B_26808549_Chip-Seq_REH_Human0.93334371
98SMAD3_21741376_ChIP-Seq_ESCs_Human0.93181700
99UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.93155579
100MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.92339787
101* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.92157367
102DNAJC2_21179169_ChIP-ChIP_NT2_Human0.92120578
103SMAD4_21741376_ChIP-Seq_HESCs_Human0.91783078
104CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91775110
105RNF2_27304074_Chip-Seq_NSC_Mouse0.91528908
106KDM2B_26808549_Chip-Seq_K562_Human0.91511634
107BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.91044317
108CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.90183571
109TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.89688030
110ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.88815113
111LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87032497
112FUS_26573619_Chip-Seq_HEK293_Human0.86577816
113EP300_21415370_ChIP-Seq_HL-1_Mouse0.86509266

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.84238145
2MP0003880_abnormal_central_pattern5.13354971
3MP0004270_analgesia3.92064976
4MP0003635_abnormal_synaptic_transmissio3.67839128
5MP0002064_seizures3.11085487
6MP0009745_abnormal_behavioral_response3.05065692
7MP0005423_abnormal_somatic_nervous3.04261375
8MP0002272_abnormal_nervous_system2.94877495
9MP0002063_abnormal_learning/memory/cond2.87091523
10MP0001486_abnormal_startle_reflex2.84573870
11MP0005551_abnormal_eye_electrophysiolog2.68459071
12MP0009046_muscle_twitch2.68266926
13MP0001968_abnormal_touch/_nociception2.47848964
14MP0002572_abnormal_emotion/affect_behav2.45985099
15MP0002734_abnormal_mechanical_nocicepti2.41579414
16MP0000920_abnormal_myelination2.39298022
17MP0002822_catalepsy2.22929588
18MP0003329_amyloid_beta_deposits2.10107077
19MP0004885_abnormal_endolymph2.09992733
20MP0001501_abnormal_sleep_pattern1.97405856
21MP0008569_lethality_at_weaning1.89529145
22MP0002735_abnormal_chemical_nociception1.86913795
23MP0002067_abnormal_sensory_capabilities1.83502862
24MP0002229_neurodegeneration1.83006136
25MP0001440_abnormal_grooming_behavior1.81667940
26MP0002736_abnormal_nociception_after1.81237279
27MP0001970_abnormal_pain_threshold1.80775036
28MP0000778_abnormal_nervous_system1.79800154
29MP0002733_abnormal_thermal_nociception1.68565638
30MP0002882_abnormal_neuron_morphology1.67272804
31MP0005253_abnormal_eye_physiology1.67016165
32MP0003690_abnormal_glial_cell1.63545530
33MP0000955_abnormal_spinal_cord1.63239018
34MP0004142_abnormal_muscle_tone1.61386259
35MP0009780_abnormal_chondrocyte_physiolo1.55796332
36MP0003633_abnormal_nervous_system1.55361202
37MP0006072_abnormal_retinal_apoptosis1.54513785
38MP0004811_abnormal_neuron_physiology1.53420015
39MP0005386_behavior/neurological_phenoty1.51038621
40MP0004924_abnormal_behavior1.51038621
41MP0004742_abnormal_vestibular_system1.50465699
42MP0003634_abnormal_glial_cell1.50397915
43MP0001529_abnormal_vocalization1.47946462
44MP0002184_abnormal_innervation1.46902425
45MP0001984_abnormal_olfaction1.44806758
46MP0002066_abnormal_motor_capabilities/c1.43316723
47MP0002557_abnormal_social/conspecific_i1.41958196
48MP0005646_abnormal_pituitary_gland1.41612379
49MP0001905_abnormal_dopamine_level1.40718724
50MP0003631_nervous_system_phenotype1.36779988
51MP0001502_abnormal_circadian_rhythm1.34236329
52MP0005409_darkened_coat_color1.31366404
53MP0003123_paternal_imprinting1.29585254
54MP0002909_abnormal_adrenal_gland1.29023752
55MP0003011_delayed_dark_adaptation1.24536650
56MP0001485_abnormal_pinna_reflex1.24437115
57MP0005171_absent_coat_pigmentation1.20724892
58MP0002752_abnormal_somatic_nervous1.20325044
59MP0004043_abnormal_pH_regulation1.19541064
60MP0005410_abnormal_fertilization1.18176796
61MP0004858_abnormal_nervous_system1.18167495
62MP0000569_abnormal_digit_pigmentation1.17733152
63MP0004147_increased_porphyrin_level1.13916245
64MP0005645_abnormal_hypothalamus_physiol1.13597459
65MP0003879_abnormal_hair_cell1.11731701
66MP0003632_abnormal_nervous_system1.11684274
67MP0003950_abnormal_plasma_membrane1.10367343
68MP0003122_maternal_imprinting1.08078271
69MP0005195_abnormal_posterior_eye1.08000185
70MP0006276_abnormal_autonomic_nervous1.07348127
71MP0004145_abnormal_muscle_electrophysio1.06917513
72MP0001963_abnormal_hearing_physiology1.06533227
73MP0002090_abnormal_vision1.06048050
74MP0002152_abnormal_brain_morphology1.02503590
75MP0008877_abnormal_DNA_methylation0.95535228
76MP0001177_atelectasis0.93245887
77MP0003787_abnormal_imprinting0.90998513
78MP0000604_amyloidosis0.88696942
79MP0001188_hyperpigmentation0.85960575
80MP0000013_abnormal_adipose_tissue0.82350060
81MP0003075_altered_response_to0.78996035
82MP0002069_abnormal_eating/drinking_beha0.78189953
83MP0001346_abnormal_lacrimal_gland0.77237630
84MP0001299_abnormal_eye_distance/0.76979092
85MP0001348_abnormal_lacrimal_gland0.76558063
86MP0000747_muscle_weakness0.75118424
87MP0002638_abnormal_pupillary_reflex0.74904106
88MP0005623_abnormal_meninges_morphology0.74690344
89MP0004085_abnormal_heartbeat0.74393530
90MP0008874_decreased_physiological_sensi0.73227872
91MP0000631_abnormal_neuroendocrine_gland0.67857930
92MP0000751_myopathy0.67843408
93MP0008872_abnormal_physiological_respon0.66964048
94MP0005394_taste/olfaction_phenotype0.66952135
95MP0005499_abnormal_olfactory_system0.66952135
96MP0004130_abnormal_muscle_cell0.65549493
97MP0005535_abnormal_body_temperature0.64244804
98MP0003283_abnormal_digestive_organ0.62744246
99MP0003137_abnormal_impulse_conducting0.61903604
100MP0003136_yellow_coat_color0.61226274
101MP0003045_fibrosis0.60517285
102MP0010769_abnormal_survival0.60293921
103MP0001664_abnormal_digestion0.59641690
104MP0003121_genomic_imprinting0.58483213
105MP0005391_vision/eye_phenotype0.58421430
106MP0010386_abnormal_urinary_bladder0.58258133
107MP0010770_preweaning_lethality0.57801376
108MP0002082_postnatal_lethality0.57801376
109MP0010768_mortality/aging0.57001234
110MP0001324_abnormal_eye_pigmentation0.56868201
111MP0001986_abnormal_taste_sensitivity0.56073463
112MP0005167_abnormal_blood-brain_barrier0.56035941
113MP0000026_abnormal_inner_ear0.54266978
114MP0003861_abnormal_nervous_system0.53326297
115MP0000566_synostosis0.51189071
116MP0001943_abnormal_respiration0.50321898
117MP0003956_abnormal_body_size0.49964098
118MP0000579_abnormal_nail_morphology0.49175160
119MP0004215_abnormal_myocardial_fiber0.46678868

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.11148681
2Myokymia (HP:0002411)6.10314851
3Focal seizures (HP:0007359)4.49949437
4Supranuclear gaze palsy (HP:0000605)4.27856261
5Neurofibrillary tangles (HP:0002185)3.97341398
6Epileptic encephalopathy (HP:0200134)3.89895987
7Congenital stationary night blindness (HP:0007642)3.86650924
8Action tremor (HP:0002345)3.78995571
9Ankle clonus (HP:0011448)3.75843709
10Visual hallucinations (HP:0002367)3.64447208
11Atonic seizures (HP:0010819)3.60527431
12Dysmetria (HP:0001310)3.54868833
13Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.53510008
14Degeneration of the lateral corticospinal tracts (HP:0002314)3.53510008
15Progressive cerebellar ataxia (HP:0002073)3.52579266
16Central scotoma (HP:0000603)3.46495894
17Febrile seizures (HP:0002373)3.40394706
18Bony spicule pigmentary retinopathy (HP:0007737)3.40263840
19Peripheral hypomyelination (HP:0007182)3.26391823
20Spastic gait (HP:0002064)3.23393043
21Abnormality of the corticospinal tract (HP:0002492)3.22596096
22Cerebral inclusion bodies (HP:0100314)3.21747148
23Abnormality of macular pigmentation (HP:0008002)3.17555873
24Hemiplegia (HP:0002301)3.13949836
25Status epilepticus (HP:0002133)3.10120752
26Intention tremor (HP:0002080)3.09354517
27Absence seizures (HP:0002121)3.03114182
28Generalized tonic-clonic seizures (HP:0002069)3.02372731
29Dialeptic seizures (HP:0011146)3.00078370
30Insidious onset (HP:0003587)2.95472102
31Termporal pattern (HP:0011008)2.95472102
32Dysdiadochokinesis (HP:0002075)2.94567854
33Scanning speech (HP:0002168)2.92983402
34Postural instability (HP:0002172)2.91734180
35Gaze-evoked nystagmus (HP:0000640)2.91394419
36Onion bulb formation (HP:0003383)2.87939610
37Broad-based gait (HP:0002136)2.87322814
38EEG with generalized epileptiform discharges (HP:0011198)2.85055078
39Truncal ataxia (HP:0002078)2.84066895
40Scotoma (HP:0000575)2.74417001
41Urinary bladder sphincter dysfunction (HP:0002839)2.72104087
42Abnormal rod and cone electroretinograms (HP:0008323)2.71585783
43Absent rod-and cone-mediated responses on ERG (HP:0007688)2.69727170
44Hypsarrhythmia (HP:0002521)2.65636330
45Depression (HP:0000716)2.64922674
46Obstructive sleep apnea (HP:0002870)2.63085771
47Impaired vibration sensation in the lower limbs (HP:0002166)2.61858837
48Urinary urgency (HP:0000012)2.59175878
49Choroideremia (HP:0001139)2.55931936
50Hyperventilation (HP:0002883)2.55398047
51Dyschromatopsia (HP:0007641)2.55346861
52Anxiety (HP:0000739)2.54637198
53Akinesia (HP:0002304)2.53866842
54Poor eye contact (HP:0000817)2.50395334
55Megalencephaly (HP:0001355)2.49609509
56Lower limb muscle weakness (HP:0007340)2.45754464
57Abolished electroretinogram (ERG) (HP:0000550)2.45726811
58Morphological abnormality of the pyramidal tract (HP:0002062)2.45629551
59Decreased central vision (HP:0007663)2.45042008
60Retinal dysplasia (HP:0007973)2.43849672
61Pheochromocytoma (HP:0002666)2.40524711
62Tetraplegia (HP:0002445)2.38637196
63Annular pancreas (HP:0001734)2.37462851
64Impaired vibratory sensation (HP:0002495)2.31356073
65Impaired social interactions (HP:0000735)2.27591487
66Abnormal social behavior (HP:0012433)2.27591487
67Cerebral hypomyelination (HP:0006808)2.27431175
68Hemiparesis (HP:0001269)2.26406393
69Abnormality of ocular smooth pursuit (HP:0000617)2.24132518
70Mutism (HP:0002300)2.22478158
71Increased circulating renin level (HP:0000848)2.22473701
72Torticollis (HP:0000473)2.21532393
73Sleep apnea (HP:0010535)2.17245764
74Excessive salivation (HP:0003781)2.17039350
75Drooling (HP:0002307)2.17039350
76Abnormal eating behavior (HP:0100738)2.14773499
77Clonus (HP:0002169)2.14607140
78Delusions (HP:0000746)2.14589122
79Choreoathetosis (HP:0001266)2.14154843
80Craniofacial dystonia (HP:0012179)2.13502236
81Amblyopia (HP:0000646)2.13455574
82Attenuation of retinal blood vessels (HP:0007843)2.12981893
83Bundle branch block (HP:0011710)2.12925213
84Absent speech (HP:0001344)2.11292595
85Slow saccadic eye movements (HP:0000514)2.10411487
86Genetic anticipation (HP:0003743)2.07151301
87Blue irides (HP:0000635)2.06426090
88Clumsiness (HP:0002312)2.05661112
89Limb dystonia (HP:0002451)2.04900656
90Progressive inability to walk (HP:0002505)2.03989668
91Bradykinesia (HP:0002067)2.02893682
92Papilledema (HP:0001085)2.02488286
93Abnormal auditory evoked potentials (HP:0006958)2.02486643
94CNS hypomyelination (HP:0003429)2.02080556
95Generalized myoclonic seizures (HP:0002123)2.00719758
96Alacrima (HP:0000522)2.00713304
97Neuroendocrine neoplasm (HP:0100634)2.00018484
98Thickened helices (HP:0000391)1.98989246
99Abnormality of binocular vision (HP:0011514)1.98729148
100Diplopia (HP:0000651)1.98729148
101Split foot (HP:0001839)1.96670057
102Focal dystonia (HP:0004373)1.96521514
103Spastic tetraparesis (HP:0001285)1.95715608
104Aplasia involving bones of the extremities (HP:0009825)1.94791777
105Aplasia involving bones of the upper limbs (HP:0009823)1.94791777
106Aplasia of the phalanges of the hand (HP:0009802)1.94791777
107Type II lissencephaly (HP:0007260)1.94400267
108Absent/shortened dynein arms (HP:0200106)1.93527119
109Dynein arm defect of respiratory motile cilia (HP:0012255)1.93527119
110Rigidity (HP:0002063)1.92311738
111Rapidly progressive (HP:0003678)1.92114713
112Incomplete penetrance (HP:0003829)1.91489571
113Abnormality of saccadic eye movements (HP:0000570)1.90595033
114Epileptiform EEG discharges (HP:0011182)1.90418468
115Impaired smooth pursuit (HP:0007772)1.88535302
116Paraplegia (HP:0010550)1.87993979
117Spastic paraplegia (HP:0001258)1.87858995
118Stereotypic behavior (HP:0000733)1.87352304
119Dysmetric saccades (HP:0000641)1.87128646
120Insomnia (HP:0100785)1.86287242
121Neuronal loss in central nervous system (HP:0002529)1.85947888
122Fetal akinesia sequence (HP:0001989)1.85325250
123Hammertoe (HP:0001765)1.84613497
124Polyphagia (HP:0002591)1.84365041
125Apathy (HP:0000741)1.84004227
126Abnormality of the periventricular white matter (HP:0002518)1.82738925
127Decreased motor nerve conduction velocity (HP:0003431)1.82284833
128Abnormality of the lower motor neuron (HP:0002366)1.79211165
129Prolonged QT interval (HP:0001657)1.78625385
130Spastic tetraplegia (HP:0002510)1.76742897
131Inability to walk (HP:0002540)1.75974590
132Bronchomalacia (HP:0002780)1.74777539

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA43.93639344
2NTRK33.86950722
3STK392.80525706
4PRKD32.71732220
5MAP3K92.63203410
6MAP3K42.33462492
7OXSR12.29535886
8PAK62.24898019
9NTRK12.16671840
10MARK12.07680131
11MINK11.99220261
12MAP2K71.83480768
13DAPK21.78924071
14KSR21.78845606
15CDK191.74691823
16LATS21.71090645
17TNIK1.68474348
18PNCK1.65360916
19UHMK11.64873832
20WNK11.62460605
21RIPK41.59598944
22NTRK21.56966683
23CDK51.55907861
24CAMK2B1.55768161
25SGK4941.51583437
26SGK2231.51583437
27CASK1.47242553
28PKN11.43603375
29PINK11.41801857
30CAMKK11.40254678
31MAP2K41.27639911
32PRPF4B1.26447737
33WNK41.26121826
34MAPKAPK51.25377701
35MAP3K21.22335088
36CAMK2D1.20159239
37NEK61.16571427
38TYRO31.16116584
39FGFR21.13896782
40GRK51.13187877
41CAMK2A1.13167721
42MAPK131.10833925
43FRK1.09538024
44STK381.09040590
45FES1.08332354
46ARAF1.05893547
47PLK21.04186483
48PRKCH1.03426525
49PHKG11.00854926
50PHKG21.00854926
51PRKCG0.99859465
52MARK20.99819927
53MAP3K130.97072252
54PAK30.96496444
55CAMK2G0.92091582
56BCR0.91826632
57GRK10.91148384
58SIK20.88175534
59STK110.87970970
60CSNK1G20.87451410
61CDK150.87211419
62CDK140.86997342
63PDPK10.85325037
64CDK180.85190516
65CAMK10.83254705
66ROCK20.81317299
67PTK2B0.81101466
68BMPR20.80989636
69CAMK40.80901734
70KSR10.79912723
71PDK10.79904042
72MAP3K120.76154643
73CDK11A0.75338292
74SGK10.72990338
75ALK0.72946068
76MAPK120.70405966
77DAPK10.68959699
78RET0.68268165
79EPHB10.68120737
80CAMKK20.66107199
81ICK0.64559968
82CAMK1G0.64360255
83PRKCE0.63552702
84CSNK1A1L0.63108949
85MAP3K10.62799541
86FGR0.62754529
87LIMK10.62528796
88DYRK1A0.62097972
89INSRR0.56621415
90MAP3K70.56424544
91FYN0.55949167
92CLK10.55726401
93PRKD10.55461559
94CSNK1G30.55360446
95MAPK100.54019717
96CDC42BPA0.51940152
97CCNB10.51639127
98SGK30.51345362
99TNK20.50213300
100SGK20.49945140
101BRAF0.49552813
102PRKCZ0.49137640
103RPS6KA30.48193457
104RIPK10.46764656
105PRKCQ0.46611279
106LMTK20.46259349
107HIPK20.44693303
108PRKG10.44513801
109AKT30.42440130
110IRAK20.41598172
111BRSK10.40885871
112CSNK1D0.39802776
113PRKCA0.38376625
114PRKCB0.37337107
115MAP3K110.36323846
116CSNK1E0.35557694
117DAPK30.35162673
118CSNK1A10.33915075
119GSK3B0.31824987
120PRKACA0.30460677

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.72334416
2Nicotine addiction_Homo sapiens_hsa050333.06731455
3Synaptic vesicle cycle_Homo sapiens_hsa047212.84487613
4GABAergic synapse_Homo sapiens_hsa047272.68004869
5Olfactory transduction_Homo sapiens_hsa047402.63788740
6Glutamatergic synapse_Homo sapiens_hsa047242.62668889
7Nitrogen metabolism_Homo sapiens_hsa009102.58294147
8Circadian entrainment_Homo sapiens_hsa047132.53891269
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.44965851
10Morphine addiction_Homo sapiens_hsa050322.35532996
11Long-term potentiation_Homo sapiens_hsa047202.29695557
12Amphetamine addiction_Homo sapiens_hsa050312.19907470
13Salivary secretion_Homo sapiens_hsa049702.10125176
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.06332974
15Dopaminergic synapse_Homo sapiens_hsa047282.00147160
16Insulin secretion_Homo sapiens_hsa049111.97870205
17Gastric acid secretion_Homo sapiens_hsa049711.86823632
18Cholinergic synapse_Homo sapiens_hsa047251.82689748
19Serotonergic synapse_Homo sapiens_hsa047261.66699164
20Cocaine addiction_Homo sapiens_hsa050301.64627313
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.57824209
22Long-term depression_Homo sapiens_hsa047301.57170582
23Taste transduction_Homo sapiens_hsa047421.57000903
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.52297880
25Renin secretion_Homo sapiens_hsa049241.49515198
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.47152078
27Oxytocin signaling pathway_Homo sapiens_hsa049211.41433365
28Calcium signaling pathway_Homo sapiens_hsa040201.39408743
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.38881119
30cAMP signaling pathway_Homo sapiens_hsa040241.27366064
31Axon guidance_Homo sapiens_hsa043601.25378962
32Phosphatidylinositol signaling system_Homo sapiens_hsa040701.24905829
33GnRH signaling pathway_Homo sapiens_hsa049121.17340694
34Collecting duct acid secretion_Homo sapiens_hsa049661.12981051
35Gap junction_Homo sapiens_hsa045401.12334289
36Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.11507514
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.08086263
38Pancreatic secretion_Homo sapiens_hsa049721.05422138
39Type II diabetes mellitus_Homo sapiens_hsa049301.03437684
40Vascular smooth muscle contraction_Homo sapiens_hsa042701.01040950
41cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00427891
42ErbB signaling pathway_Homo sapiens_hsa040120.95281865
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95221872
44Vibrio cholerae infection_Homo sapiens_hsa051100.93651301
45Dorso-ventral axis formation_Homo sapiens_hsa043200.91275789
46Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.91140120
47Phospholipase D signaling pathway_Homo sapiens_hsa040720.89121978
48Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.89075228
49Estrogen signaling pathway_Homo sapiens_hsa049150.86426138
50Melanogenesis_Homo sapiens_hsa049160.86143823
51Ether lipid metabolism_Homo sapiens_hsa005650.86027071
52Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.85764488
53Cardiac muscle contraction_Homo sapiens_hsa042600.84903234
54Histidine metabolism_Homo sapiens_hsa003400.84264134
55Glioma_Homo sapiens_hsa052140.83117145
56Thyroid hormone synthesis_Homo sapiens_hsa049180.77364304
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.76243482
58SNARE interactions in vesicular transport_Homo sapiens_hsa041300.75765598
59Ras signaling pathway_Homo sapiens_hsa040140.70868456
60Choline metabolism in cancer_Homo sapiens_hsa052310.70613487
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70210863
62Inositol phosphate metabolism_Homo sapiens_hsa005620.68634702
63Sphingolipid signaling pathway_Homo sapiens_hsa040710.67106264
64Endocytosis_Homo sapiens_hsa041440.66709100
65MAPK signaling pathway_Homo sapiens_hsa040100.65618557
66Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62895416
67Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62513765
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62034212
69Dilated cardiomyopathy_Homo sapiens_hsa054140.60371673
70Oocyte meiosis_Homo sapiens_hsa041140.57439318
71Renal cell carcinoma_Homo sapiens_hsa052110.55952531
72Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.55771769
73Fatty acid elongation_Homo sapiens_hsa000620.54438101
74Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53656141
75Glycerophospholipid metabolism_Homo sapiens_hsa005640.52325454
76beta-Alanine metabolism_Homo sapiens_hsa004100.51904100
77Bile secretion_Homo sapiens_hsa049760.49254035
78Ovarian steroidogenesis_Homo sapiens_hsa049130.49205272
79VEGF signaling pathway_Homo sapiens_hsa043700.49137232
80Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48671252
81Rap1 signaling pathway_Homo sapiens_hsa040150.47088508
82Mineral absorption_Homo sapiens_hsa049780.46123202
83Arginine and proline metabolism_Homo sapiens_hsa003300.45276143
84Alcoholism_Homo sapiens_hsa050340.44238728
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44142586
86Fatty acid biosynthesis_Homo sapiens_hsa000610.43912459
87Tight junction_Homo sapiens_hsa045300.43110530
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42825910
89Prion diseases_Homo sapiens_hsa050200.40223071
90Wnt signaling pathway_Homo sapiens_hsa043100.38922122
91Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.38327804
92Circadian rhythm_Homo sapiens_hsa047100.37246042
93Vitamin B6 metabolism_Homo sapiens_hsa007500.35973115
94Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.33944070
95Chemokine signaling pathway_Homo sapiens_hsa040620.33415740
96Glucagon signaling pathway_Homo sapiens_hsa049220.33134000
97Sphingolipid metabolism_Homo sapiens_hsa006000.32819209
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32608233
99Thyroid hormone signaling pathway_Homo sapiens_hsa049190.31915843
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.31869548
101Longevity regulating pathway - mammal_Homo sapiens_hsa042110.31583539
102Hippo signaling pathway_Homo sapiens_hsa043900.30486079
103Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.28759559
104African trypanosomiasis_Homo sapiens_hsa051430.28468422
105Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.27998354
106ABC transporters_Homo sapiens_hsa020100.27236492
107Alzheimers disease_Homo sapiens_hsa050100.26309000
108Type I diabetes mellitus_Homo sapiens_hsa049400.26123464
109Arginine biosynthesis_Homo sapiens_hsa002200.25063744
110mTOR signaling pathway_Homo sapiens_hsa041500.24204764
111Butanoate metabolism_Homo sapiens_hsa006500.24025709

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