PEX14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an essential component of the peroxisomal import machinery. The protein is integrated into peroxisome membranes with its C-terminus exposed to the cytosol, and interacts with the cytosolic receptor for proteins containing a PTS1 peroxisomal targeting signal. The protein also functions as a transcriptional corepressor and interacts with a histone deacetylase. A mutation in this gene results in one form of Zellweger syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1histone H4-K12 acetylation (GO:0043983)9.22098611
2lipopolysaccharide metabolic process (GO:0008653)8.93064288
3negative regulation of glycogen biosynthetic process (GO:0045719)7.96625627
4protein-cofactor linkage (GO:0018065)7.41024042
5nucleotide transport (GO:0006862)7.32014178
6regulation of isotype switching to IgG isotypes (GO:0048302)7.17288854
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.45445242
8L-phenylalanine metabolic process (GO:0006558)6.45445242
9negative regulation of glycogen metabolic process (GO:0070874)6.39973085
10L-phenylalanine catabolic process (GO:0006559)6.34459135
11erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.34459135
12rRNA catabolic process (GO:0016075)6.25588286
13positive regulation of isotype switching (GO:0045830)6.18794949
14DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla6.14090476
15spliceosomal snRNP assembly (GO:0000387)5.99554810
16antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.91121096
17DNA damage response, signal transduction resulting in transcription (GO:0042772)5.84558716
18antigen processing and presentation via MHC class Ib (GO:0002475)5.79027312
19DNA deamination (GO:0045006)5.66990776
20regulation of telomere maintenance via telomerase (GO:0032210)5.66036274
21triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.59253207
22glyoxylate metabolic process (GO:0046487)5.53577059
23aromatic amino acid family catabolic process (GO:0009074)5.49365832
24extracellular regulation of signal transduction (GO:1900115)5.46755000
25extracellular negative regulation of signal transduction (GO:1900116)5.46755000
26sulfur amino acid catabolic process (GO:0000098)5.42023667
27macrophage chemotaxis (GO:0048246)5.37567652
28alpha-linolenic acid metabolic process (GO:0036109)5.35573542
29negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.35130281
30negative regulation of cell killing (GO:0031342)5.35130281
31positive regulation of DNA recombination (GO:0045911)5.20682059
32kynurenine metabolic process (GO:0070189)5.15497395
33negative regulation of fibrinolysis (GO:0051918)5.10239671
34lysine metabolic process (GO:0006553)5.08810570
35lysine catabolic process (GO:0006554)5.08810570
36bile acid biosynthetic process (GO:0006699)5.01256563
37cysteine metabolic process (GO:0006534)4.97498740
38microglial cell activation (GO:0001774)4.94843088
39urea cycle (GO:0000050)4.91990724
40urea metabolic process (GO:0019627)4.91990724
41high-density lipoprotein particle remodeling (GO:0034375)4.90959801
42regulation of energy homeostasis (GO:2000505)4.88944866
43fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.83373777
44tryptophan catabolic process (GO:0006569)4.82791243
45indole-containing compound catabolic process (GO:0042436)4.82791243
46indolalkylamine catabolic process (GO:0046218)4.82791243
47serine family amino acid catabolic process (GO:0009071)4.82679815
48macrophage activation involved in immune response (GO:0002281)4.79820280
49adaptation of signaling pathway (GO:0023058)4.78797040
50negative regulation of telomerase activity (GO:0051974)4.73404864
51negative regulation of sterol transport (GO:0032372)4.68624110
52negative regulation of cholesterol transport (GO:0032375)4.68624110
53regulation of monocyte differentiation (GO:0045655)4.68597359
54positive regulation of mast cell degranulation (GO:0043306)4.62796517
55positive regulation of mast cell activation involved in immune response (GO:0033008)4.62796517
56keratan sulfate biosynthetic process (GO:0018146)4.59693414
57antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.58194648
58RNA capping (GO:0036260)4.56119693
597-methylguanosine RNA capping (GO:0009452)4.56119693
60negative regulation of telomere maintenance (GO:0032205)4.55769526
61nitrogen cycle metabolic process (GO:0071941)4.54102377
62tryptophan metabolic process (GO:0006568)4.53142417
63regulation of fibrinolysis (GO:0051917)4.51835421
64glycine metabolic process (GO:0006544)4.51636813
65positive regulation of mast cell activation (GO:0033005)4.46281977
66amino-acid betaine metabolic process (GO:0006577)4.42757256
67protein carboxylation (GO:0018214)4.42076704
68peptidyl-glutamic acid carboxylation (GO:0017187)4.42076704
69regulation of triglyceride catabolic process (GO:0010896)4.39516254
70regulation of protein activation cascade (GO:2000257)4.37594246
71RNA methylation (GO:0001510)4.37507990
72homocysteine metabolic process (GO:0050667)4.37230991
73positive regulation of T cell mediated cytotoxicity (GO:0001916)4.30575677
74mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.27537602
75bile acid metabolic process (GO:0008206)4.26756128
76plasma lipoprotein particle clearance (GO:0034381)4.26536687
77triglyceride homeostasis (GO:0070328)4.24158123
78acylglycerol homeostasis (GO:0055090)4.24158123
79complement activation, alternative pathway (GO:0006957)4.21878229
80histone H4-K5 acetylation (GO:0043981)4.19189369
81histone H4-K8 acetylation (GO:0043982)4.19189369
82aromatic amino acid family metabolic process (GO:0009072)4.19125933
83regulation of cholesterol esterification (GO:0010872)4.17689253
84regulation of extracellular matrix disassembly (GO:0010715)4.16424913
85alpha-amino acid catabolic process (GO:1901606)4.15948250
86serine family amino acid metabolic process (GO:0009069)4.15882291
87reverse cholesterol transport (GO:0043691)4.13192204
88regulation of complement activation (GO:0030449)4.09080408
89plasma lipoprotein particle remodeling (GO:0034369)4.08213614
90protein-lipid complex remodeling (GO:0034368)4.08213614
91macromolecular complex remodeling (GO:0034367)4.08213614
92serine family amino acid biosynthetic process (GO:0009070)4.03090096
932-oxoglutarate metabolic process (GO:0006103)4.02871122
94cellular ketone body metabolic process (GO:0046950)4.01523621
95positive regulation of interleukin-17 production (GO:0032740)4.00907221
96ribosomal small subunit biogenesis (GO:0042274)4.00723892
97cellular amino acid catabolic process (GO:0009063)3.97524309
98regulation of cholesterol homeostasis (GO:2000188)3.94349817
99cellular modified amino acid catabolic process (GO:0042219)3.93625883
100tyrosine metabolic process (GO:0006570)3.90757770
101viral transcription (GO:0019083)3.87505847
102coenzyme catabolic process (GO:0009109)3.86335970
103acetyl-CoA metabolic process (GO:0006084)3.81658621
104platelet dense granule organization (GO:0060155)3.79162792
105positive regulation of fatty acid beta-oxidation (GO:0032000)3.76946811
106aspartate family amino acid catabolic process (GO:0009068)3.76807705
107fatty acid beta-oxidation (GO:0006635)3.74758641
108drug catabolic process (GO:0042737)3.73206526
109phospholipid efflux (GO:0033700)3.72892066
110negative regulation of fatty acid biosynthetic process (GO:0045717)3.72161117
111glutamate metabolic process (GO:0006536)3.71497499
112keratan sulfate metabolic process (GO:0042339)3.71072620
113positive regulation of lipid catabolic process (GO:0050996)3.67514584
114antigen processing and presentation of endogenous antigen (GO:0019883)3.64978471
115regulation of fatty acid beta-oxidation (GO:0031998)3.64536624
116mannose metabolic process (GO:0006013)3.63932673
117fatty acid oxidation (GO:0019395)3.62220967
118benzene-containing compound metabolic process (GO:0042537)3.59700150
119cellular response to pH (GO:0071467)3.59239800
120cortical actin cytoskeleton organization (GO:0030866)3.58440614
121ethanol oxidation (GO:0006069)3.58429997
122carboxylic acid catabolic process (GO:0046395)3.57675041
123organic acid catabolic process (GO:0016054)3.57675041
124fatty acid transmembrane transport (GO:1902001)3.55339349
125ribonucleoprotein complex biogenesis (GO:0022613)3.54135532
126negative regulation of glucose import (GO:0046325)3.53118600
127regulation of isotype switching (GO:0045191)3.52531109
128lipid oxidation (GO:0034440)3.52511464
129imidazole-containing compound metabolic process (GO:0052803)3.52360074
130heme transport (GO:0015886)3.52195700
131positive regulation of B cell mediated immunity (GO:0002714)3.51820490
132positive regulation of immunoglobulin mediated immune response (GO:0002891)3.51820490
133regulation of T cell mediated cytotoxicity (GO:0001914)3.51378708
134dicarboxylic acid biosynthetic process (GO:0043650)3.51061424
135plasma lipoprotein particle assembly (GO:0034377)3.50284371
136valine metabolic process (GO:0006573)3.50058222
137short-chain fatty acid metabolic process (GO:0046459)3.47892389
138fatty acid catabolic process (GO:0009062)3.47358819
139cilium or flagellum-dependent cell motility (GO:0001539)3.46561048
140translational termination (GO:0006415)3.46291542
141nucleoside diphosphate phosphorylation (GO:0006165)3.46023599
142activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO3.45063541
143regulation of telomerase activity (GO:0051972)3.44669206
144monocarboxylic acid catabolic process (GO:0072329)3.44558937
145cholesterol efflux (GO:0033344)3.44470985
146ketone body metabolic process (GO:1902224)3.42560310
147epoxygenase P450 pathway (GO:0019373)3.42398293
148positive regulation of triglyceride lipase activity (GO:0061365)3.42391506
149positive regulation of lipoprotein lipase activity (GO:0051006)3.42391506
150carnitine metabolic process (GO:0009437)3.42238989
151fatty acid homeostasis (GO:0055089)3.39482701
152cholesterol homeostasis (GO:0042632)3.38591747
153arginine metabolic process (GO:0006525)3.38129521
154positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.37982056
155glycerophospholipid catabolic process (GO:0046475)3.34984766
156drug metabolic process (GO:0017144)3.34044355
157positive regulation of triglyceride metabolic process (GO:0090208)3.32338228
158carnitine shuttle (GO:0006853)3.31910850
159sterol homeostasis (GO:0055092)3.31477323
160cellular glucuronidation (GO:0052695)3.30830151
161exogenous drug catabolic process (GO:0042738)3.30668322
162low-density lipoprotein particle clearance (GO:0034383)3.30302836
163bile acid and bile salt transport (GO:0015721)3.29035295
164fibrinolysis (GO:0042730)3.27536327
165positive regulation of leukocyte degranulation (GO:0043302)3.27372876
166positive regulation of natural killer cell mediated immunity (GO:0002717)3.26439546
167thrombin receptor signaling pathway (GO:0070493)3.25969454
168cortical cytoskeleton organization (GO:0030865)3.22239918
169sleep (GO:0030431)3.21211628
170ncRNA catabolic process (GO:0034661)3.20174842
171positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003573.18960074
172deoxyribonucleoside diphosphate metabolic process (GO:0009186)3.17663089
173regulation of protein kinase A signaling (GO:0010738)3.17475436
174ribosomal small subunit assembly (GO:0000028)3.16892264
175positive regulation of immunoglobulin production (GO:0002639)3.09074954
176carbohydrate derivative transport (GO:1901264)3.07089212
177entrainment of circadian clock by photoperiod (GO:0043153)3.05171156
178positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.04332851
179cellular zinc ion homeostasis (GO:0006882)3.00699589
180ADP metabolic process (GO:0046031)3.00205070
181regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.97868676
182positive regulation vascular endothelial growth factor production (GO:0010575)2.97312097
183cellular response to interleukin-4 (GO:0071353)2.97185915
184ribosome assembly (GO:0042255)2.92901172
185establishment or maintenance of apical/basal cell polarity (GO:0035088)2.92886535
186establishment or maintenance of bipolar cell polarity (GO:0061245)2.92886535
187low-density lipoprotein particle remodeling (GO:0034374)2.86728308
188viral life cycle (GO:0019058)2.84901760
189histone H4-K16 acetylation (GO:0043984)2.84447802
190positive regulation of leukocyte mediated immunity (GO:0002705)2.82481751
191maturation of 5.8S rRNA (GO:0000460)19.1069366
192nucleotide transmembrane transport (GO:1901679)14.1853891
193T-helper 1 type immune response (GO:0042088)11.1075936
194lipopolysaccharide biosynthetic process (GO:0009103)10.1978344

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.52540840
2STAT6_21828071_ChIP-Seq_BEAS2B_Human6.46229858
3* RXR_22158963_ChIP-Seq_LIVER_Mouse5.98696078
4* PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.71823910
5* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.44136394
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.53241362
7* LXR_22158963_ChIP-Seq_LIVER_Mouse4.37785680
8CHD7_19251738_ChIP-ChIP_MESCs_Mouse4.13483725
9EGR1_23403033_ChIP-Seq_LIVER_Mouse3.86366928
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.77931239
11CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.63765743
12RBPJ_22232070_ChIP-Seq_NCS_Mouse3.52475068
13IKZF1_21737484_ChIP-ChIP_HCT116_Human2.91941795
14YY1_21170310_ChIP-Seq_MESCs_Mouse2.76765982
15NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.74857439
16TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.73566573
17CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.73317781
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.30070165
19EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.28121394
20THAP11_20581084_ChIP-Seq_MESCs_Mouse2.15122726
21ZNF263_19887448_ChIP-Seq_K562_Human2.08679979
22CLOCK_20551151_ChIP-Seq_293T_Human2.00228129
23TDRD3_21172665_ChIP-Seq_MCF-7_Human1.92922566
24RARG_19884340_ChIP-ChIP_MEFs_Mouse1.90991604
25VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.88594947
26NOTCH1_21737748_ChIP-Seq_TLL_Human1.86413843
27ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.84795567
28HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.80084378
29EGR1_19374776_ChIP-ChIP_THP-1_Human1.79865345
30NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.74491994
31RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.74136438
32LXR_22292898_ChIP-Seq_THP-1_Human1.67187191
33STAT3_1855785_ChIP-Seq_MESCs_Mouse1.66338291
34* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65486937
35E2F7_22180533_ChIP-Seq_HELA_Human1.60306431
36TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.58518439
37SOX2_18555785_ChIP-Seq_MESCs_Mouse1.57773876
38THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.57265956
39EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56747979
40BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.56410116
41POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.54435114
42TRIM28_21343339_ChIP-Seq_HEK293_Human1.48744739
43NANOG_18555785_ChIP-Seq_MESCs_Mouse1.40642642
44TP63_17297297_ChIP-ChIP_HaCaT_Human1.40572596
45MYC_18555785_ChIP-Seq_MESCs_Mouse1.40381464
46ELF1_17652178_ChIP-ChIP_JURKAT_Human1.40234349
47MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.37432262
48TP63_19390658_ChIP-ChIP_HaCaT_Human1.36195110
49* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.34306644
50KDM2B_26808549_Chip-Seq_SUP-B15_Human1.31432204
51CTCF_26484167_Chip-Seq_Bcells_Mouse1.31307649
52SMC4_20622854_ChIP-Seq_HELA_Human1.30499115
53TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.27556121
54RACK7_27058665_Chip-Seq_MCF-7_Human1.26817706
55DCP1A_22483619_ChIP-Seq_HELA_Human1.26698334
56STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.26433990
57* SA1_27219007_Chip-Seq_Bcells_Human1.23904967
58FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.20484603
59SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19234619
60TET1_21451524_ChIP-Seq_MESCs_Mouse1.18527903
61ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.18215610
62JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.17638405
63KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.16309568
64SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.15130817
65RNF2_18974828_ChIP-Seq_MESCs_Mouse1.14749252
66EZH2_18974828_ChIP-Seq_MESCs_Mouse1.14749252
67ATF3_27146783_Chip-Seq_COLON_Human1.14609715
68RXRA_24833708_ChIP-Seq_LIVER_Mouse1.14036584
69ESR1_15608294_ChIP-ChIP_MCF-7_Human1.12286353
70* SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.11605787
71MYC_18358816_ChIP-ChIP_MESCs_Mouse1.11494972
72IRF1_19129219_ChIP-ChIP_H3396_Human1.11402974
73SRY_22984422_ChIP-ChIP_TESTIS_Rat1.11138017
74IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.09774297
75RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.09188512
76CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.09115378
77ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.08634443
78P68_20966046_ChIP-Seq_HELA_Human1.08116419
79EED_16625203_ChIP-ChIP_MESCs_Mouse1.06213875
80* ELK3_25401928_ChIP-Seq_HUVEC_Human1.05347279
81ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.02795050
82MYC_19915707_ChIP-ChIP_AK7_Human1.02759716
83* HNF4A_19822575_ChIP-Seq_HepG2_Human1.02399691
84STAT4_19710469_ChIP-ChIP_TH1__Mouse1.01999158
85* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.01675372
86TAF2_19829295_ChIP-Seq_ESCs_Human1.01662299
87* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.01375235
88NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.01360437
89TP53_20018659_ChIP-ChIP_R1E_Mouse1.00282871
90MYC_22102868_ChIP-Seq_BL_Human1.00212524
91BCL6_27268052_Chip-Seq_Bcells_Human0.99971944
92SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.99615175
93ELF1_20517297_ChIP-Seq_JURKAT_Human0.99448686
94ESR2_21235772_ChIP-Seq_MCF-7_Human0.99260033
95NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.99154987
96BCOR_27268052_Chip-Seq_Bcells_Human0.99073808
97FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98729500
98ZFP281_18757296_ChIP-ChIP_E14_Mouse0.97663634
99KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.96526773
100BP1_19119308_ChIP-ChIP_Hs578T_Human0.96264131
101FOXM1_23109430_ChIP-Seq_U2OS_Human0.96213893
102RARA_24833708_ChIP-Seq_LIVER_Mouse0.95671348
103* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.95639085
104RAD21_21589869_ChIP-Seq_MESCs_Mouse0.95001830
105SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.94161901
106CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.93339881
107SOX2_18692474_ChIP-Seq_MEFs_Mouse0.93259640
108* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.93103365
109RARB_24833708_ChIP-Seq_LIVER_Mouse0.92504116
110KLF4_18555785_ChIP-Seq_MESCs_Mouse0.92381899
111ERG_21242973_ChIP-ChIP_JURKAT_Human0.91825705
112CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91414525
113* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.91188107
114* FOXA2_19822575_ChIP-Seq_HepG2_Human0.91118245
115* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90929366
116PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.90807476
117YY1_22570637_ChIP-Seq_MALME-3M_Human0.90708797
118* JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.90523188
119MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.90331594
120VDR_24763502_ChIP-Seq_THP-1_Human0.90028930
121XRN2_22483619_ChIP-Seq_HELA_Human0.89560056
122PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.88729460
123ZFX_18555785_ChIP-Seq_MESCs_Mouse0.88278070
124* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.87852551
125DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.87708547
126PHF8_20622854_ChIP-Seq_HELA_Human0.87414981
127* CREB1_26743006_Chip-Seq_LNCaP_Human0.86944084
128CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.85570998
129AR_21909140_ChIP-Seq_LNCAP_Human0.85370349
130MYC_19079543_ChIP-ChIP_MESCs_Mouse0.84676409
131* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.83985064
132MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.83705239
133NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.83438347
134* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.83358469
135SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.83063396
136SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.82884137
137SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.82723779
138GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.81811639
139FOXP1_21924763_ChIP-Seq_HESCs_Human0.81601617
140* SA1_27219007_Chip-Seq_ERYTHROID_Human0.80979248
141CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.80530979
142CTCF_21964334_ChIP-Seq_BJAB-B_Human0.79937382
143CTCF_21964334_Chip-Seq_Bcells_Human0.79575593
144SOX2_27498859_Chip-Seq_STOMACH_Mouse0.79554454
145MYC_19030024_ChIP-ChIP_MESCs_Mouse0.78833942
146NELFA_20434984_ChIP-Seq_ESCs_Mouse0.77046531
147SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.76921614
148ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.76752460
149CREB1_15753290_ChIP-ChIP_HEK293T_Human0.76681860
150HIF1A_21447827_ChIP-Seq_MCF-7_Human0.76477946
151TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.75305362
152E2F1_20622854_ChIP-Seq_HELA_Human0.75050314
153VDR_21846776_ChIP-Seq_THP-1_Human0.75005574
154TCF3_18692474_ChIP-Seq_MEFs_Mouse0.74401327
155* ETS1_20019798_ChIP-Seq_JURKAT_Human0.73693829
156POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.72804556
157CTCF_27219007_Chip-Seq_Bcells_Human0.72353903
158GABP_19822575_ChIP-Seq_HepG2_Human0.71855116

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006082_CNS_inflammation9.74968469
2MP0002139_abnormal_hepatobiliary_system7.28520593
3MP0005360_urolithiasis6.70279736
4MP0005365_abnormal_bile_salt5.75470852
5MP0005085_abnormal_gallbladder_physiolo5.54305066
6MP0001348_abnormal_lacrimal_gland4.92001947
7MP0001346_abnormal_lacrimal_gland4.60895665
8MP0001873_stomach_inflammation4.56062004
9MP0002132_abnormal_respiratory_system4.48754559
10MP0008875_abnormal_xenobiotic_pharmacok4.23862132
11MP0003806_abnormal_nucleotide_metabolis4.23597173
12MP0003300_gastrointestinal_ulcer3.82654728
13MP0009840_abnormal_foam_cell3.73332627
14MP0003690_abnormal_glial_cell3.67890562
15MP0010329_abnormal_lipoprotein_level3.40346802
16MP0002876_abnormal_thyroid_physiology3.35729236
17MP0003252_abnormal_bile_duct3.11131803
18MP0005083_abnormal_biliary_tract2.89583094
19MP0005332_abnormal_amino_acid2.87301520
20MP0003705_abnormal_hypodermis_morpholog2.61175533
21MP0001666_abnormal_nutrient_absorption2.25134056
22MP0005670_abnormal_white_adipose2.20015937
23MP0003195_calcinosis2.18158407
24MP0000609_abnormal_liver_physiology2.11644790
25MP0009333_abnormal_splenocyte_physiolog2.09245072
26MP0004019_abnormal_vitamin_homeostasis2.05817747
27MP0002118_abnormal_lipid_homeostasis2.02044643
28MP0003191_abnormal_cellular_cholesterol1.98494866
29MP0005319_abnormal_enzyme/_coenzyme1.97130778
30MP0005671_abnormal_response_to1.82975374
31MP0005310_abnormal_salivary_gland1.63354726
32MP0003950_abnormal_plasma_membrane1.57517094
33MP0009643_abnormal_urine_homeostasis1.53288351
34MP0002405_respiratory_system_inflammati1.50324139
35MP0002837_dystrophic_cardiac_calcinosis1.49089645
36MP0005584_abnormal_enzyme/coenzyme_acti1.48165258
37MP0005451_abnormal_body_composition1.48161619
38MP0000858_altered_metastatic_potential1.47597053
39MP0002277_abnormal_respiratory_mucosa1.43667865
40MP0002138_abnormal_hepatobiliary_system1.41080609
41MP0000920_abnormal_myelination1.38024927
42MP0003186_abnormal_redox_activity1.37675988
43MP0001915_intracranial_hemorrhage1.33708144
44MP0004130_abnormal_muscle_cell1.33488814
45MP0001764_abnormal_homeostasis1.27181810
46MP0005595_abnormal_vascular_smooth1.25711234
47MP0000598_abnormal_liver_morphology1.25564258
48MP0006036_abnormal_mitochondrial_physio1.22516832
49MP0001984_abnormal_olfaction1.22423163
50MP0003011_delayed_dark_adaptation1.20996471
51MP0001663_abnormal_digestive_system1.20455455
52MP0005197_abnormal_uvea_morphology1.18576942
53MP0000685_abnormal_immune_system1.17364404
54MP0000613_abnormal_salivary_gland1.17127360
55MP0001756_abnormal_urination1.16177904
56MP0001851_eye_inflammation1.15854543
57MP0005666_abnormal_adipose_tissue1.15740132
58MP0002269_muscular_atrophy1.14787401
59MP0009379_abnormal_foot_pigmentation1.06935323
60MP0009785_altered_susceptibility_to1.05925161
61MP0003868_abnormal_feces_composition1.04013887
62MP0005266_abnormal_metabolism1.03046555
63MP0005166_decreased_susceptibility_to1.02470482
64MP0003656_abnormal_erythrocyte_physiolo1.01802921
65MP0009046_muscle_twitch1.00152314
66MP0000604_amyloidosis0.96503641
67MP0006035_abnormal_mitochondrial_morpho0.92525466
68MP0002078_abnormal_glucose_homeostasis0.92012718
69MP0004883_abnormal_blood_vessel0.91972188
70MP0005381_digestive/alimentary_phenotyp0.90743538
71MP0005636_abnormal_mineral_homeostasis0.89843680
72MP0002970_abnormal_white_adipose0.88119186
73MP0003329_amyloid_beta_deposits0.87207324
74MP0002971_abnormal_brown_adipose0.86825297
75MP0009053_abnormal_anal_canal0.85754416
76MP0003763_abnormal_thymus_physiology0.84865812
77MP0006292_abnormal_olfactory_placode0.83752509
78MP0004185_abnormal_adipocyte_glucose0.82787251
79MP0005334_abnormal_fat_pad0.82197818
80MP0009642_abnormal_blood_homeostasis0.81451024
81MP0001919_abnormal_reproductive_system0.80619185
82MP0005376_homeostasis/metabolism_phenot0.80191488
83MP0010155_abnormal_intestine_physiology0.77267465
84MP0002796_impaired_skin_barrier0.77048829
85MP0005000_abnormal_immune_tolerance0.75376834
86MP0005330_cardiomyopathy0.75171279
87MP0009672_abnormal_birth_weight0.75146391
88MP0004858_abnormal_nervous_system0.74836628
89MP0005025_abnormal_response_to0.74432685
90MP0005164_abnormal_response_to0.72606772
91MP0004264_abnormal_extraembryonic_tissu0.71959691
92MP0003693_abnormal_embryo_hatching0.70865181
93MP0002909_abnormal_adrenal_gland0.70631820
94MP0003448_altered_tumor_morphology0.68075404
95MP0003646_muscle_fatigue0.67917545
96MP0005375_adipose_tissue_phenotype0.67155295
97MP0008961_abnormal_basal_metabolism0.66774458
98MP0005448_abnormal_energy_balance0.66660935
99MP0002163_abnormal_gland_morphology0.66365024
100MP0001661_extended_life_span0.66257671
101MP0009763_increased_sensitivity_to0.65991527
102MP0004859_abnormal_synaptic_plasticity0.65643396
103MP0005023_abnormal_wound_healing0.65503530
104MP0003566_abnormal_cell_adhesion0.64542384
105MP0010234_abnormal_vibrissa_follicle0.61592460
106MP0005647_abnormal_sex_gland0.61551506
107MP0009697_abnormal_copulation0.60924521
108MP0002693_abnormal_pancreas_physiology0.60817392
109MP0009115_abnormal_fat_cell0.60424152
110MP0000747_muscle_weakness0.59635628
111MP0002136_abnormal_kidney_physiology0.58190285
112MP0005220_abnormal_exocrine_pancreas0.55962619
113MP0009765_abnormal_xenobiotic_induced0.55629431
114MP0000639_abnormal_adrenal_gland0.55543182
115MP0003879_abnormal_hair_cell0.55245747
116MP0008469_abnormal_protein_level0.54961888
117MP0010368_abnormal_lymphatic_system0.54781477
118MP0002419_abnormal_innate_immunity0.53959648
119MP0000358_abnormal_cell_content/0.53453378
120MP0000013_abnormal_adipose_tissue0.53372480
121MP0005535_abnormal_body_temperature0.53039125
122MP0002254_reproductive_system_inflammat0.52485018
123MP0003953_abnormal_hormone_level0.52192471
124MP0000631_abnormal_neuroendocrine_gland0.52101383
125MP0000703_abnormal_thymus_morphology0.51657115
126MP0000537_abnormal_urethra_morphology0.51615973
127MP0008438_abnormal_cutaneous_collagen0.51266310
128MP0003718_maternal_effect0.51264197
129MP0003634_abnormal_glial_cell0.50587816
130MP0004133_heterotaxia0.50532244
131MP0001119_abnormal_female_reproductive0.49588053
132MP0001730_embryonic_growth_arrest0.47928768
133MP0002998_abnormal_bone_remodeling0.47193840
134MP0003119_abnormal_digestive_system0.46600074
135MP0000470_abnormal_stomach_morphology0.46030200
136MP0003221_abnormal_cardiomyocyte_apopto0.45988890
137MP0005395_other_phenotype0.45660003
138MP0005389_reproductive_system_phenotype0.45646940
139MP0010352_gastrointestinal_tract_polyps0.45606709
140MP0004087_abnormal_muscle_fiber0.45291892
141MP0002135_abnormal_kidney_morphology0.44150654
142MP0010030_abnormal_orbit_morphology0.44054786
143MP0000465_gastrointestinal_hemorrhage0.43304780
144MP0004233_abnormal_muscle_weight0.42298788
145MP0002452_abnormal_antigen_presenting0.41419542
146MP0005385_cardiovascular_system_phenoty0.41409361
147MP0001544_abnormal_cardiovascular_syste0.41409361
148MP0000751_myopathy0.41327573
149MP0008872_abnormal_physiological_respon0.41073494
150MP0003699_abnormal_female_reproductive0.40774958
151MP0005084_abnormal_gallbladder_morpholo0.40657716
152MP0002060_abnormal_skin_morphology0.40261651
153MP0000230_abnormal_systemic_arterial0.40140304
154MP0000477_abnormal_intestine_morphology0.40105327
155MP0005058_abnormal_lysosome_morphology0.40022394
156MP0004084_abnormal_cardiac_muscle0.39558470
157MP0002420_abnormal_adaptive_immunity0.39422593
158MP0001819_abnormal_immune_cell0.38870982
159MP0002723_abnormal_immune_serum0.35397312
160MP0001944_abnormal_pancreas_morphology0.34334608
161MP0001800_abnormal_humoral_immune0.34227533
162MP0003075_altered_response_to0.33553724
163MP0000759_abnormal_skeletal_muscle0.33212102
164MP0008873_increased_physiological_sensi0.32716442
165MP0008770_decreased_survivor_rate0.32544031
166MP0003786_premature_aging0.31478544
167MP0003111_abnormal_nucleus_morphology0.30825754
168MP0002822_catalepsy0.29556866
169MP0002229_neurodegeneration0.29553909
170MP0000716_abnormal_immune_system0.29548735
171MP0003436_decreased_susceptibility_to0.29479759
172MP0001790_abnormal_immune_system0.28496963
173MP0005387_immune_system_phenotype0.28496963
174MP0003183_abnormal_peptide_metabolism0.27949010
175MP0000249_abnormal_blood_vessel0.26346678
176MP0005379_endocrine/exocrine_gland_phen0.25400008
177MP0001845_abnormal_inflammatory_respons0.24987342
178MP0004885_abnormal_endolymph0.24580643
179MP0008569_lethality_at_weaning0.23617237
180MP0002429_abnormal_blood_cell0.19906389
181MP0000733_abnormal_muscle_development0.19548842

Predicted human phenotypes

RankGene SetZ-score
1Nasal polyposis (HP:0100582)8.44894822
2Abnormality of the nasal mucosa (HP:0000433)7.22707962
3Autoimmune thrombocytopenia (HP:0001973)6.99600434
4Recurrent cutaneous fungal infections (HP:0011370)6.58544321
5Chronic mucocutaneous candidiasis (HP:0002728)6.58544321
6Deep venous thrombosis (HP:0002625)6.24542440
7Asplenia (HP:0001746)6.23980855
8Abnormality of aromatic amino acid family metabolism (HP:0004338)6.06088526
9Aplasia/Hypoplasia of the spleen (HP:0010451)5.74884210
10Xanthomatosis (HP:0000991)5.68683776
11Abnormality of monocarboxylic acid metabolism (HP:0010996)5.67726298
12Intrahepatic cholestasis (HP:0001406)5.59575038
13Keratoconjunctivitis (HP:0001096)5.43900029
14Hypercortisolism (HP:0001578)5.33182708
15Hypobetalipoproteinemia (HP:0003563)5.24453839
16Oral leukoplakia (HP:0002745)5.09208769
17Aplastic anemia (HP:0001915)4.99210947
18Stomatitis (HP:0010280)4.87407212
19Abnormality of calcium-phosphate metabolism (HP:0100530)4.80104193
20Alopecia of scalp (HP:0002293)4.73580600
21Hyperammonemia (HP:0001987)4.64332277
22Recurrent fungal infections (HP:0002841)4.54224189
23Ketosis (HP:0001946)4.45292623
24Syringomyelia (HP:0003396)4.45039956
25Spinal cord lesions (HP:0100561)4.45039956
26Pustule (HP:0200039)4.44818328
27Hyperlipoproteinemia (HP:0010980)4.40240229
28Hyperglycinuria (HP:0003108)4.30248795
29Hypoparathyroidism (HP:0000829)4.29052326
30Prolonged partial thromboplastin time (HP:0003645)4.28742005
31Hypolipoproteinemia (HP:0010981)4.28564088
32Type I diabetes mellitus (HP:0100651)4.19842319
33Abnormality of homocysteine metabolism (HP:0010919)4.17652970
34Homocystinuria (HP:0002156)4.17652970
35Hypoglycemic coma (HP:0001325)4.17522308
36Complement deficiency (HP:0004431)4.13196891
37Hyperglycinemia (HP:0002154)4.10698819
38Hypoalphalipoproteinemia (HP:0003233)4.04357527
39Abnormality of serine family amino acid metabolism (HP:0010894)4.00457323
40Abnormality of glycine metabolism (HP:0010895)4.00457323
41Increased IgM level (HP:0003496)3.83431361
42Abnormality of B cell number (HP:0010975)3.79533358
43Abnormality of glutamine family amino acid metabolism (HP:0010902)3.79353474
44Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.73275167
45Epidermoid cyst (HP:0200040)3.67050814
46Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.65920781
47Abnormality of fatty-acid metabolism (HP:0004359)3.65373356
48Ketoacidosis (HP:0001993)3.64920884
49Abnormality of sulfur amino acid metabolism (HP:0004339)3.64093839
50Methylmalonic acidemia (HP:0002912)3.45844788
51Hypercholesterolemia (HP:0003124)3.41046425
52Abnormality of pyrimidine metabolism (HP:0004353)3.32956789
53Abnormality of the common coagulation pathway (HP:0010990)3.30843672
54Abnormality of aspartate family amino acid metabolism (HP:0010899)3.27332227
55Increased IgE level (HP:0003212)3.25889619
56Gout (HP:0001997)3.20112104
57Respiratory distress (HP:0002098)3.15637009
58Agammaglobulinemia (HP:0004432)3.13968072
59Abnormality of methionine metabolism (HP:0010901)3.08409616
60Abnormality of the lower motor neuron (HP:0002366)3.07878045
61Abnormality of complement system (HP:0005339)3.06435922
62Autoimmune hemolytic anemia (HP:0001890)3.03850381
63Delayed CNS myelination (HP:0002188)3.02147358
64Joint hemorrhage (HP:0005261)3.00259694
65Loss of speech (HP:0002371)2.99225543
66Dicarboxylic aciduria (HP:0003215)2.97585011
67Abnormality of dicarboxylic acid metabolism (HP:0010995)2.97585011
68Fat malabsorption (HP:0002630)2.97461981
69Abnormality of the intrinsic pathway (HP:0010989)2.97250466
70Abnormality of nucleobase metabolism (HP:0010932)2.94844876
71Polyphagia (HP:0002591)2.91277623
72Distal lower limb amyotrophy (HP:0008944)2.89380792
73Abnormality of T cell physiology (HP:0011840)2.88970175
74Stomach cancer (HP:0012126)2.87568922
75Abnormal delayed hypersensitivity skin test (HP:0002963)2.86276132
76Slender build (HP:0001533)2.81104542
77Abnormality of purine metabolism (HP:0004352)2.75788919
78Lethargy (HP:0001254)2.73684522
79Neonatal onset (HP:0003623)2.73591184
80Hyperbilirubinemia (HP:0002904)2.72637436
81Abnormality of serum amino acid levels (HP:0003112)2.70696572
82Keratitis (HP:0000491)2.70567366
83Abnormality of cells of the lymphoid lineage (HP:0012140)2.67777597
84Late onset (HP:0003584)2.66004080
85Recurrent skin infections (HP:0001581)2.65156295
86Skin nodule (HP:0200036)2.62363370
87Metabolic acidosis (HP:0001942)2.59445845
88Myoglobinuria (HP:0002913)2.57420238
89Hepatocellular carcinoma (HP:0001402)2.55249287
90Rough bone trabeculation (HP:0100670)2.54978885
91Abnormal gallbladder physiology (HP:0012438)2.54188829
92Cholecystitis (HP:0001082)2.54188829
93Cerebral edema (HP:0002181)2.51559184
94Megaloblastic anemia (HP:0001889)2.49290804
95Gastrointestinal stroma tumor (HP:0100723)2.48627849
96Cholelithiasis (HP:0001081)2.44063547
97Spastic diplegia (HP:0001264)2.43506275
98Adrenal overactivity (HP:0002717)2.42169299
99Hypoglycemic seizures (HP:0002173)2.40362719
100Tetany (HP:0001281)2.36836422
101Myocardial infarction (HP:0001658)2.35738258
102Abnormal gallbladder morphology (HP:0012437)2.35522906
103Methylmalonic aciduria (HP:0012120)2.34345098
104Abnormality of the Achilles tendon (HP:0005109)2.33748920
105Malnutrition (HP:0004395)2.32411447
106Abnormal cartilage morphology (HP:0002763)2.31909206
107Hyperinsulinemic hypoglycemia (HP:0000825)2.30253078
108Irritability (HP:0000737)2.29933077
109Hypergammaglobulinemia (HP:0010702)2.29885640
110Pancytopenia (HP:0001876)2.27237471
111Vomiting (HP:0002013)2.26577306
112Cheilitis (HP:0100825)2.21233606
113Hypochromic anemia (HP:0001931)2.20791893
114Aplasia involving bones of the extremities (HP:0009825)2.18968772
115Aplasia involving bones of the upper limbs (HP:0009823)2.18968772
116Aplasia of the phalanges of the hand (HP:0009802)2.18968772
117Abnormal drinking behavior (HP:0030082)2.17975322
118Polydipsia (HP:0001959)2.17975322
119Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.17880987
120Cerebellar dysplasia (HP:0007033)2.16317420
121Increased purine levels (HP:0004368)2.16232626
122Hyperuricemia (HP:0002149)2.16232626
123Abnormality of the gastric mucosa (HP:0004295)2.13493495
124Rhabdomyolysis (HP:0003201)2.12715243
125Hypertriglyceridemia (HP:0002155)2.08110285
126Spontaneous abortion (HP:0005268)2.06614538
127Generalized aminoaciduria (HP:0002909)2.05766968
128Sensorimotor neuropathy (HP:0007141)2.04521559
129Abnormality of T cells (HP:0002843)2.04125100
130Steatorrhea (HP:0002570)2.03810549
131Hyperglycemia (HP:0003074)2.03407773
132Hypoplasia of the capital femoral epiphysis (HP:0003090)2.03263849
133Diplopia (HP:0000651)2.01296106
134Abnormality of binocular vision (HP:0011514)2.01296106
135Abnormality of the phalanges of the hallux (HP:0010057)2.00363630
136Emphysema (HP:0002097)2.00358661
137Macrocytic anemia (HP:0001972)2.00309949
138* Brushfield spots (HP:0001088)1.99826069
139Lower limb amyotrophy (HP:0007210)1.99597174
140Hand muscle atrophy (HP:0009130)1.99040627
141Esophageal varix (HP:0002040)1.98975169
142Neurofibrillary tangles (HP:0002185)1.98468983
143Conjugated hyperbilirubinemia (HP:0002908)1.97230596
144Ragged-red muscle fibers (HP:0003200)1.97113307
145Abnormal trabecular bone morphology (HP:0100671)1.95785102
146Hypoplasia of the pons (HP:0012110)1.95220204
147* Primary adrenal insufficiency (HP:0008207)1.94967659
148Turricephaly (HP:0000262)1.94098959
149Pulmonary fibrosis (HP:0002206)1.94001966
150Nausea (HP:0002018)1.93423080
151Neutropenia (HP:0001875)1.92843695
152Hepatitis (HP:0012115)1.92424718
153Thoracic kyphosis (HP:0002942)1.91459129
154Polycythemia (HP:0001901)1.91132546
155Hypoplasia of dental enamel (HP:0006297)1.90267579
156Hydroxyprolinuria (HP:0003080)1.90144425
157Abnormality of proline metabolism (HP:0010907)1.90144425
158Vascular calcification (HP:0004934)1.89354132
159Enlarged kidneys (HP:0000105)1.89254195
160Abnormality of the gallbladder (HP:0005264)1.88999451
161Pancreatitis (HP:0001733)1.86931541
162Multiple enchondromatosis (HP:0005701)1.86645662
163Back pain (HP:0003418)1.86259047
164Lymphopenia (HP:0001888)1.85901172
165Leukopenia (HP:0001882)1.85795189
166Opisthotonus (HP:0002179)1.85602816
167Fibular aplasia (HP:0002990)1.85593332
168Abnormality of transition element cation homeostasis (HP:0011030)1.85089514
169Hypopigmented skin patches (HP:0001053)1.84913738
170Upper limb amyotrophy (HP:0009129)1.84301508
171Distal upper limb amyotrophy (HP:0007149)1.84301508
172Right ventricular cardiomyopathy (HP:0011663)1.84079430
173Abnormality of magnesium homeostasis (HP:0004921)1.83809848
174Abnormality of endocrine pancreas physiology (HP:0012093)1.83762504
175Abnormality of the pancreatic islet cells (HP:0006476)1.83762504
176Proximal tubulopathy (HP:0000114)1.83441197
177Chronic diarrhea (HP:0002028)1.83267051
178Systemic lupus erythematosus (HP:0002725)1.82988024
179Hypomagnesemia (HP:0002917)1.81424888
180Abnormality of iron homeostasis (HP:0011031)1.80316666
181Cerebral palsy (HP:0100021)1.79208522
182Absent epiphyses (HP:0010577)1.76026184
183Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.76026184
184Increased density of long bones (HP:0006392)1.74601894
185Duplication of thumb phalanx (HP:0009942)1.73583330
186Follicular hyperkeratosis (HP:0007502)1.73502386
187Aplasia/Hypoplasia of the sacrum (HP:0008517)1.73436534
188Type II lissencephaly (HP:0007260)1.73170233
189Short tibia (HP:0005736)1.72255634
190Optic nerve coloboma (HP:0000588)1.70470646
191Abnormality of the vitamin B12 metabolism (HP:0004341)1.70041513
192Hemiplegia (HP:0002301)1.69873932
193Lymphangioma (HP:0100764)1.69319728
194Hepatocellular necrosis (HP:0001404)1.66265616
195Abnormality of the pons (HP:0007361)1.62546777

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PASK9.95206314
2MAP3K139.34853473
3BCKDK5.65858426
4ERN14.17037202
5CAMKK14.03362194
6TRIB33.88389925
7MAP3K143.76934268
8PKN23.27502745
9MAP3K103.18240365
10ITK2.99950961
11FGR2.97375243
12SIK12.93057742
13NEK12.45393935
14FGFR42.20543388
15MAPKAPK32.16439899
16EEF2K2.01648745
17LATS21.83331457
18BUB11.71019981
19MAP3K111.69726743
20FLT31.65912061
21MAP3K121.64309567
22EPHA21.63928623
23TESK21.60863245
24CSK1.48451016
25KDR1.44060195
26KSR21.37146469
27ICK1.34425525
28DAPK21.33673997
29MAPK111.27540227
30PKN11.27528148
31MAP3K71.22570520
32RIPK11.17047851
33PTK61.14809913
34PDK31.12868231
35PDK41.12868231
36MAP2K41.12391870
37ARAF1.11210767
38IKBKB1.10482404
39NME21.10456500
40DYRK1B1.10260396
41MAP3K31.09899338
42FGFR11.06885204
43MAP2K11.05040118
44RPS6KB21.02771573
45MTOR1.01927082
46STK100.99895344
47MAPK70.99029423
48GSK3A0.99029347
49LRRK20.98430746
50TESK10.94269793
51ERBB40.93003659
52TTK0.92163647
53MST1R0.91673073
54PAK40.87695445
55PDGFRA0.87479664
56JAK10.86394488
57TAOK10.85333633
58TTN0.84866645
59PINK10.84766098
60MAP3K90.80864116
61MAP3K20.79814383
62PTK20.78537969
63INSRR0.78371376
64EPHB20.77818168
65ABL20.76578946
66AURKA0.74340443
67MAP2K20.73772224
68DAPK30.71894634
69SCYL20.68735929
70PRKAA10.68497363
71MAP3K80.67666020
72BRAF0.67518403
73CAMK1D0.67387420
74DAPK10.67347363
75PRKD30.66868913
76BMX0.65789022
77EIF2AK10.62969313
78STK38L0.61462734
79PIM20.60957611
80IRAK30.60703638
81PRKAA20.60375978
82NEK90.59903660
83ACVR1B0.59031814
84TAOK20.58959316
85MAP2K30.58579321
86CHEK20.57566855
87CHUK0.57402237
88CDK40.57059899
89FER0.55889479
90LMTK20.54661312
91ERBB20.54370905
92PAK30.53397599
93GRK60.53100828
94TYK20.52902261
95NTRK10.51009965
96JAK20.50786824
97PRKACG0.47909562
98VRK20.47588242
99AKT20.46711325
100KSR10.46658859
101PRPF4B0.45742979
102PRKCZ0.45546630
103DYRK30.45033331
104NEK20.44729704
105TGFBR10.43829513
106PRKG20.43480885
107STK160.43375511
108CDK60.43201155
109MAPK120.42949845
110MAPK40.42318049
111MET0.40781210
112STK380.39269797
113PRKCQ0.38497146
114FYN0.37505285
115SMG10.35628387
116MAP3K10.35512010
117CAMK2G0.35309174
118PIK3CG0.34841046
119MAP3K50.33581211
120RPS6KA10.32916070
121ALK0.32740959
122EPHA30.31728013
123PAK10.31065208
124PDK20.30878696
125CDC70.30844149
126PDPK10.30719241
127LIMK10.30370387
128CSNK1A10.29520740
129PAK60.29316254
130UHMK10.29292485
131RET0.29182745
132CSNK1E0.28807028
133PDK10.28656571
134NME10.25650570
135CAMK2B0.23921824
136CDK70.23420077
137PLK10.23134598
138CSNK1G30.20909656
139BTK0.20603239
140TIE10.19845872
141MAPK10.17896956
142ILK0.16254567
143PRKDC0.14789667
144LYN0.13506695
145EPHA40.13035265
146TBK10.12962269
147RPS6KA40.11993500
148PIM10.11581769
149PHKG20.11547248
150PHKG10.11547248
151SGK10.10518007
152MUSK0.10263698
153CSNK2A10.09902883
154MST40.09755571
155MAPK150.09061081
156OBSCN0.08307307
157CSNK2A20.07074602
158LCK0.06701501
159HIPK20.06671128
160SRC0.06351740

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.21422760
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.92541671
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.55068334
4Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.54675574
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.10719411
6Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.07247631
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006303.01304035
8Nitrogen metabolism_Homo sapiens_hsa009102.95365722
9Arginine biosynthesis_Homo sapiens_hsa002202.88915329
10Cardiac muscle contraction_Homo sapiens_hsa042602.72683998
11Primary immunodeficiency_Homo sapiens_hsa053402.69342766
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.63760276
13Fatty acid degradation_Homo sapiens_hsa000712.63056294
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.58051714
15Graft-versus-host disease_Homo sapiens_hsa053322.55892355
16Tryptophan metabolism_Homo sapiens_hsa003802.51353481
17Alzheimers disease_Homo sapiens_hsa050102.48665178
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.43180699
19RNA polymerase_Homo sapiens_hsa030202.38779703
20Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.32044340
21Autoimmune thyroid disease_Homo sapiens_hsa053202.28525583
22Propanoate metabolism_Homo sapiens_hsa006402.25214356
23Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.20859436
24Butanoate metabolism_Homo sapiens_hsa006502.17471634
25Allograft rejection_Homo sapiens_hsa053302.13474827
26RNA degradation_Homo sapiens_hsa030182.12480108
27Complement and coagulation cascades_Homo sapiens_hsa046102.06789490
28Pentose and glucuronate interconversions_Homo sapiens_hsa000402.05068680
29B cell receptor signaling pathway_Homo sapiens_hsa046622.04944518
30Fatty acid metabolism_Homo sapiens_hsa012122.00062624
31Fanconi anemia pathway_Homo sapiens_hsa034601.99591654
32PPAR signaling pathway_Homo sapiens_hsa033201.97433013
33* Peroxisome_Homo sapiens_hsa041461.88933254
34Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.85196156
35Drug metabolism - other enzymes_Homo sapiens_hsa009831.81634602
36Biosynthesis of amino acids_Homo sapiens_hsa012301.80699268
37Carbon metabolism_Homo sapiens_hsa012001.80521142
38Selenocompound metabolism_Homo sapiens_hsa004501.76444058
39Pyruvate metabolism_Homo sapiens_hsa006201.76229261
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.70537208
41Caffeine metabolism_Homo sapiens_hsa002321.66092655
42Chemical carcinogenesis_Homo sapiens_hsa052041.64615462
43Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.63888214
44Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.62369551
45beta-Alanine metabolism_Homo sapiens_hsa004101.61077956
46Cyanoamino acid metabolism_Homo sapiens_hsa004601.59994502
47Type I diabetes mellitus_Homo sapiens_hsa049401.52247858
48Phenylalanine metabolism_Homo sapiens_hsa003601.48985437
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.48962503
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.45072460
51Fat digestion and absorption_Homo sapiens_hsa049751.39960221
52Mineral absorption_Homo sapiens_hsa049781.39418414
53Bile secretion_Homo sapiens_hsa049761.36409978
54Malaria_Homo sapiens_hsa051441.36147623
55Histidine metabolism_Homo sapiens_hsa003401.34281621
56Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.34251499
57Steroid hormone biosynthesis_Homo sapiens_hsa001401.32538113
58Sulfur relay system_Homo sapiens_hsa041221.31730045
59Retinol metabolism_Homo sapiens_hsa008301.29189487
60Folate biosynthesis_Homo sapiens_hsa007901.28878351
61Dilated cardiomyopathy_Homo sapiens_hsa054141.28413469
62Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.27658649
63Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.25849459
64Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.25128982
65Tyrosine metabolism_Homo sapiens_hsa003501.20054148
66Epstein-Barr virus infection_Homo sapiens_hsa051691.18343925
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.18267060
68Starch and sucrose metabolism_Homo sapiens_hsa005001.17904505
69Salmonella infection_Homo sapiens_hsa051321.14829174
70DNA replication_Homo sapiens_hsa030301.14605397
71RNA transport_Homo sapiens_hsa030131.11892323
72One carbon pool by folate_Homo sapiens_hsa006701.10286564
73Purine metabolism_Homo sapiens_hsa002301.08070109
74Sulfur metabolism_Homo sapiens_hsa009201.07536597
75Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.07447637
76Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.07414459
77Chemokine signaling pathway_Homo sapiens_hsa040621.01853496
78Arginine and proline metabolism_Homo sapiens_hsa003301.00960601
79Pentose phosphate pathway_Homo sapiens_hsa000300.99977149
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.97895039
81Staphylococcus aureus infection_Homo sapiens_hsa051500.97848064
82Fatty acid elongation_Homo sapiens_hsa000620.96775903
83Dorso-ventral axis formation_Homo sapiens_hsa043200.95802418
84Vitamin B6 metabolism_Homo sapiens_hsa007500.95767470
85RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.94364272
86Lysine degradation_Homo sapiens_hsa003100.91433451
87Viral myocarditis_Homo sapiens_hsa054160.91319347
88Legionellosis_Homo sapiens_hsa051340.90697496
89Maturity onset diabetes of the young_Homo sapiens_hsa049500.88127446
90NOD-like receptor signaling pathway_Homo sapiens_hsa046210.87790542
91Glycerolipid metabolism_Homo sapiens_hsa005610.86177535
92Acute myeloid leukemia_Homo sapiens_hsa052210.84721049
93Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.83768925
94Fructose and mannose metabolism_Homo sapiens_hsa000510.80835200
95ABC transporters_Homo sapiens_hsa020100.78805464
96Glutathione metabolism_Homo sapiens_hsa004800.77579830
97Antigen processing and presentation_Homo sapiens_hsa046120.76631480
98Rheumatoid arthritis_Homo sapiens_hsa053230.75562526
99Spliceosome_Homo sapiens_hsa030400.75070401
100T cell receptor signaling pathway_Homo sapiens_hsa046600.74353805
101Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.73464710
102Jak-STAT signaling pathway_Homo sapiens_hsa046300.71967141
103Apoptosis_Homo sapiens_hsa042100.71124621
104African trypanosomiasis_Homo sapiens_hsa051430.69981284
105Fatty acid biosynthesis_Homo sapiens_hsa000610.69889333
106Vitamin digestion and absorption_Homo sapiens_hsa049770.68346745
107Collecting duct acid secretion_Homo sapiens_hsa049660.68126867
108Galactose metabolism_Homo sapiens_hsa000520.67932155
109Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.64088447
110HTLV-I infection_Homo sapiens_hsa051660.59592405
111Herpes simplex infection_Homo sapiens_hsa051680.58850761
112TNF signaling pathway_Homo sapiens_hsa046680.57026124
113Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56822323
114Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56279018
115Metabolic pathways_Homo sapiens_hsa011000.49964017
116Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.49090726
117MAPK signaling pathway_Homo sapiens_hsa040100.45586523
118Chronic myeloid leukemia_Homo sapiens_hsa052200.44301265
119Type II diabetes mellitus_Homo sapiens_hsa049300.44050734
120Adipocytokine signaling pathway_Homo sapiens_hsa049200.42472353
121Tight junction_Homo sapiens_hsa045300.40462979
122Osteoclast differentiation_Homo sapiens_hsa043800.38796773
123Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.38703825
124Glucagon signaling pathway_Homo sapiens_hsa049220.38144671
125Insulin resistance_Homo sapiens_hsa049310.38057119
126Steroid biosynthesis_Homo sapiens_hsa001000.36817022
127Hepatitis B_Homo sapiens_hsa051610.32313234
128AMPK signaling pathway_Homo sapiens_hsa041520.31208879
129Prion diseases_Homo sapiens_hsa050200.29986803
130Tuberculosis_Homo sapiens_hsa051520.28539982
131Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.27160856
132Central carbon metabolism in cancer_Homo sapiens_hsa052300.25804732
133Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.24960811
134Glycerophospholipid metabolism_Homo sapiens_hsa005640.24722443
135cAMP signaling pathway_Homo sapiens_hsa040240.24189078
136Circadian rhythm_Homo sapiens_hsa047100.23434247
137Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.23070410
138Toxoplasmosis_Homo sapiens_hsa051450.22828712
139Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.22236146
140Neurotrophin signaling pathway_Homo sapiens_hsa047220.22065129
141Insulin signaling pathway_Homo sapiens_hsa049100.21165084
142FoxO signaling pathway_Homo sapiens_hsa040680.20363006
143Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.18537650
144Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.18401320
145Bladder cancer_Homo sapiens_hsa052190.17827835
146NF-kappa B signaling pathway_Homo sapiens_hsa040640.17755595
147Influenza A_Homo sapiens_hsa051640.17523926
148alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.16989556
149Proteasome_Homo sapiens_hsa030500.14040438
150Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.13500011
151Arachidonic acid metabolism_Homo sapiens_hsa005900.11281169
152Pancreatic cancer_Homo sapiens_hsa052120.11259448
153Linoleic acid metabolism_Homo sapiens_hsa005910.09777398
154Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.07684921
155Regulation of autophagy_Homo sapiens_hsa041400.02146726
156Longevity regulating pathway - mammal_Homo sapiens_hsa042110.01850379
157Huntingtons disease_Homo sapiens_hsa05016-0.1527510
158Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1446698
159Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1339228
160Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1189907
161Thyroid cancer_Homo sapiens_hsa05216-0.1152599
162mTOR signaling pathway_Homo sapiens_hsa04150-0.0906908
163Renin-angiotensin system_Homo sapiens_hsa04614-0.0837140
164Oxidative phosphorylation_Homo sapiens_hsa00190-0.0562554
165Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.0547757
166Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961-0.0424159
167Pyrimidine metabolism_Homo sapiens_hsa00240-0.0299885
168Parkinsons disease_Homo sapiens_hsa05012-0.0167995

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »