PEX11B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene facilitates peroxisomal proliferation and interacts with PEX19. The encoded protein is found in the peroxisomal membrane. Several transcript variants, some protein-coding and some not protein-coding, have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.87336195
2L-phenylalanine metabolic process (GO:0006558)4.87336195
3L-phenylalanine catabolic process (GO:0006559)4.62563754
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.62563754
5respiratory chain complex IV assembly (GO:0008535)4.33024565
6mitochondrial respiratory chain complex I assembly (GO:0032981)4.31241200
7NADH dehydrogenase complex assembly (GO:0010257)4.31241200
8mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.31241200
9succinate metabolic process (GO:0006105)4.29346689
10oxaloacetate metabolic process (GO:0006107)4.27945517
11protein complex biogenesis (GO:0070271)4.10674613
12chaperone-mediated protein transport (GO:0072321)4.08022398
13oxidative phosphorylation (GO:0006119)4.04353788
14mitochondrial respiratory chain complex assembly (GO:0033108)3.92022440
15NADH metabolic process (GO:0006734)3.85431256
16branched-chain amino acid catabolic process (GO:0009083)3.84522511
17tricarboxylic acid cycle (GO:0006099)3.81306171
18mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.78538693
19mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.70362881
20respiratory electron transport chain (GO:0022904)3.69420308
21electron transport chain (GO:0022900)3.64709536
22L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.63051284
23lysine catabolic process (GO:0006554)3.61130599
24lysine metabolic process (GO:0006553)3.61130599
25aerobic respiration (GO:0009060)3.57879397
26platelet dense granule organization (GO:0060155)3.53061038
27aromatic amino acid family catabolic process (GO:0009074)3.52707816
28amino acid salvage (GO:0043102)3.50572675
29L-methionine salvage (GO:0071267)3.50572675
30L-methionine biosynthetic process (GO:0071265)3.50572675
31inositol phosphate catabolic process (GO:0071545)3.47364822
32protein deneddylation (GO:0000338)3.46529558
33ketone body metabolic process (GO:1902224)3.41241350
34cytochrome complex assembly (GO:0017004)3.40088120
35aspartate family amino acid catabolic process (GO:0009068)3.33047173
36neutrophil mediated immunity (GO:0002446)3.30416181
37energy coupled proton transport, down electrochemical gradient (GO:0015985)3.25647676
38ATP synthesis coupled proton transport (GO:0015986)3.25647676
39negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.20296894
40aldehyde catabolic process (GO:0046185)3.17687198
41mannosylation (GO:0097502)3.16071441
42coenzyme catabolic process (GO:0009109)3.15541192
43DNA deamination (GO:0045006)3.14097067
44piRNA metabolic process (GO:0034587)3.12890311
45bile acid biosynthetic process (GO:0006699)3.11901634
46killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.11719612
47disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.11719612
48branched-chain amino acid metabolic process (GO:0009081)3.11428323
49response to misfolded protein (GO:0051788)3.11298847
50purine deoxyribonucleotide metabolic process (GO:0009151)3.11096006
51peptidyl-cysteine modification (GO:0018198)3.07615340
52transferrin transport (GO:0033572)3.07551471
53tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.05737379
54RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.05737379
55inner mitochondrial membrane organization (GO:0007007)3.04867474
56nucleotide salvage (GO:0043173)3.04425924
57anterograde synaptic vesicle transport (GO:0048490)3.02280841
58cullin deneddylation (GO:0010388)3.01049055
59keratinocyte development (GO:0003334)2.98949412
60misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.97327444
61regulation of chemokine biosynthetic process (GO:0045073)2.96001857
62xenobiotic catabolic process (GO:0042178)2.95840315
63pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.95615905
64inositol phosphate dephosphorylation (GO:0046855)2.95495303
65phosphorylated carbohydrate dephosphorylation (GO:0046838)2.95495303
66regulation of acyl-CoA biosynthetic process (GO:0050812)2.93870798
67* peroxisome fission (GO:0016559)2.93087434
68NAD metabolic process (GO:0019674)2.92756690
69positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.92528018
70cofactor catabolic process (GO:0051187)2.89145872
71proteasome assembly (GO:0043248)2.88783023
72regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.86839784
73trivalent inorganic cation transport (GO:0072512)2.84773841
74ferric iron transport (GO:0015682)2.84773841
75glyoxylate metabolic process (GO:0046487)2.84739649
76regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.84479815
77amino-acid betaine metabolic process (GO:0006577)2.84449429
78deoxyribonucleotide catabolic process (GO:0009264)2.83856962
79lactate metabolic process (GO:0006089)2.81785658
80deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.81155142
81protein-cofactor linkage (GO:0018065)2.79414465
82purine nucleotide salvage (GO:0032261)2.79245178
83fatty acid catabolic process (GO:0009062)2.78200657
84intraciliary transport (GO:0042073)2.77492493
852-deoxyribonucleotide metabolic process (GO:0009394)2.75670804
86protein localization to cilium (GO:0061512)2.74711272
87regulation of coenzyme metabolic process (GO:0051196)2.74421463
88regulation of cofactor metabolic process (GO:0051193)2.74421463
89base-excision repair, AP site formation (GO:0006285)2.73510986
90alpha-amino acid catabolic process (GO:1901606)2.73450158
91serine family amino acid catabolic process (GO:0009071)2.72430129
92fatty acid beta-oxidation (GO:0006635)2.71143216
93cysteine metabolic process (GO:0006534)2.69906192
94regulation of cellular amino acid metabolic process (GO:0006521)2.69239615
95cellular respiration (GO:0045333)2.68747100
96deoxyribose phosphate metabolic process (GO:0019692)2.68528207
97deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.67926668
98gluconeogenesis (GO:0006094)2.67556210
99hydrogen ion transmembrane transport (GO:1902600)2.66668099
100* peroxisome organization (GO:0007031)2.66478335
101cellular ketone body metabolic process (GO:0046950)2.66143989
102drug transmembrane transport (GO:0006855)2.65576799
103indolalkylamine catabolic process (GO:0046218)2.65019126
104tryptophan catabolic process (GO:0006569)2.65019126
105indole-containing compound catabolic process (GO:0042436)2.65019126
106deoxyribose phosphate catabolic process (GO:0046386)2.64720237
107response to nitrosative stress (GO:0051409)2.64497060
108phagosome maturation (GO:0090382)2.64240572
109aromatic amino acid family metabolic process (GO:0009072)2.63787793
110S-adenosylmethionine metabolic process (GO:0046500)2.63740230
111arginine catabolic process (GO:0006527)2.63413143
112dopamine transport (GO:0015872)2.62885003
113glycine metabolic process (GO:0006544)2.62656718
114methionine metabolic process (GO:0006555)2.62513276
115quinone biosynthetic process (GO:1901663)2.61725315
116ubiquinone biosynthetic process (GO:0006744)2.61725315
117aspartate family amino acid metabolic process (GO:0009066)2.60978854
118disruption of cells of other organism (GO:0044364)2.60810187
119killing of cells of other organism (GO:0031640)2.60810187
120axoneme assembly (GO:0035082)2.60664146
121purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.60517017
122synaptic vesicle maturation (GO:0016188)2.60456268
123purine nucleoside triphosphate biosynthetic process (GO:0009145)2.60380448
124purine deoxyribonucleotide catabolic process (GO:0009155)2.59426241
1252-oxoglutarate metabolic process (GO:0006103)2.59422688
126arginine metabolic process (GO:0006525)2.57923405
127regulation of memory T cell differentiation (GO:0043380)2.57677262
128negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.56522055
129ATP biosynthetic process (GO:0006754)2.56399308
130synaptic vesicle exocytosis (GO:0016079)2.56046827
131proton transport (GO:0015992)2.55849318
132carnitine metabolic process (GO:0009437)2.55065648
133triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.54978208
134fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.54734718
135hydrogen transport (GO:0006818)2.54620206
136pyrimidine-containing compound salvage (GO:0008655)2.54266456
137pyrimidine nucleoside salvage (GO:0043097)2.54266456
138purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.53494790
139short-chain fatty acid metabolic process (GO:0046459)2.53014975
140ATP hydrolysis coupled proton transport (GO:0015991)2.52697960
141energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.52697960
142glutamate secretion (GO:0014047)2.51517833
143fatty acid elongation (GO:0030497)2.51477904
144nucleoside salvage (GO:0043174)2.51057068
145bile acid metabolic process (GO:0008206)2.50835971
146cellular amino acid catabolic process (GO:0009063)2.50829249
147ADP metabolic process (GO:0046031)2.50767884
148ether lipid metabolic process (GO:0046485)2.50628668
149dicarboxylic acid catabolic process (GO:0043649)2.50474455
150sulfur amino acid biosynthetic process (GO:0000097)2.49662399
151deoxyribose phosphate biosynthetic process (GO:0046385)2.49622237
1522-deoxyribonucleotide biosynthetic process (GO:0009265)2.49622237
153hexose biosynthetic process (GO:0019319)2.48950607
154monocarboxylic acid catabolic process (GO:0072329)2.48199429
155negative regulation of synaptic transmission, GABAergic (GO:0032229)2.47586705
156iron-sulfur cluster assembly (GO:0016226)2.47548935
157metallo-sulfur cluster assembly (GO:0031163)2.47548935
158deoxyribonucleotide metabolic process (GO:0009262)2.46870032
159protein neddylation (GO:0045116)2.46839422
160GPI anchor metabolic process (GO:0006505)2.46549789
161negative regulation of calcium ion transmembrane transport (GO:1903170)2.46318641
162negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.46318641
163negative regulation of cation channel activity (GO:2001258)2.46063047
164lipopolysaccharide biosynthetic process (GO:0009103)2.45785571
165phenylpropanoid metabolic process (GO:0009698)2.44136155
166regulation of activation of Janus kinase activity (GO:0010533)2.42569303
167lipopolysaccharide metabolic process (GO:0008653)2.39326713
168histamine secretion (GO:0001821)2.37450266
169cellular metabolic compound salvage (GO:0043094)2.36033283
170dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.35320903

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.64662742
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.80997224
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.54588080
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.13134019
5PDX1_19855005_ChIP-ChIP_MIN6_Mouse3.03388515
6GABP_17652178_ChIP-ChIP_JURKAT_Human2.92402211
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.81103494
8EGR1_23403033_ChIP-Seq_LIVER_Mouse2.72197193
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.69594326
10RXR_22158963_ChIP-Seq_LIVER_Mouse2.61611883
11SRF_21415370_ChIP-Seq_HL-1_Mouse2.59115205
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.56177104
13CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.53686661
14ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.43888400
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.43671276
16PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.39281355
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.38676980
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.33597903
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.32950161
20GBX2_23144817_ChIP-Seq_PC3_Human2.20125982
21THAP11_20581084_ChIP-Seq_MESCs_Mouse2.17800985
22PPARA_22158963_ChIP-Seq_LIVER_Mouse2.03114231
23CREB1_15753290_ChIP-ChIP_HEK293T_Human1.98657742
24NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.97086350
25* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.92283453
26PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.91849785
27IRF8_22096565_ChIP-ChIP_GC-B_Human1.90546591
28IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.89976318
29FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.86669521
30* FOXP3_21729870_ChIP-Seq_TREG_Human1.83933677
31MYC_18555785_ChIP-Seq_MESCs_Mouse1.83318392
32ELK1_19687146_ChIP-ChIP_HELA_Human1.79402914
33TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.78827150
34TAF15_26573619_Chip-Seq_HEK293_Human1.76872163
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.74049816
36ZNF274_21170338_ChIP-Seq_K562_Hela1.69655802
37IRF8_21731497_ChIP-ChIP_J774_Mouse1.69510409
38ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.69219609
39E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.69137655
40* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.66266842
41GATA1_22025678_ChIP-Seq_K562_Human1.66088211
42MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.63236569
43DCP1A_22483619_ChIP-Seq_HELA_Human1.62477393
44GABP_19822575_ChIP-Seq_HepG2_Human1.58809502
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.58478865
46BP1_19119308_ChIP-ChIP_Hs578T_Human1.53900313
47ER_23166858_ChIP-Seq_MCF-7_Human1.53567440
48E2F1_18555785_ChIP-Seq_MESCs_Mouse1.52346601
49CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.48785203
50HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.46164632
51TP53_22573176_ChIP-Seq_HFKS_Human1.44693369
52PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44166953
53SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.41861408
54* VDR_23849224_ChIP-Seq_CD4+_Human1.41285381
55CTCF_18555785_ChIP-Seq_MESCs_Mouse1.40977711
56HOXB4_20404135_ChIP-ChIP_EML_Mouse1.40366549
57LXR_22158963_ChIP-Seq_LIVER_Mouse1.38726350
58RBPJ_22232070_ChIP-Seq_NCS_Mouse1.37489588
59SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.35537253
60FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.35306370
61MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.35050919
62FOXA1_27270436_Chip-Seq_PROSTATE_Human1.34272063
63FOXA1_25329375_ChIP-Seq_VCAP_Human1.34272063
64VDR_22108803_ChIP-Seq_LS180_Human1.31607638
65SMAD_19615063_ChIP-ChIP_OVARY_Human1.31186810
66LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.30671584
67REST_18959480_ChIP-ChIP_MESCs_Mouse1.29054390
68CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.27856991
69RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.25771565
70EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.25438352
71GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25233029
72EWS_26573619_Chip-Seq_HEK293_Human1.24609278
73FUS_26573619_Chip-Seq_HEK293_Human1.24141158
74IRF1_19129219_ChIP-ChIP_H3396_Human1.20480272
75AR_20517297_ChIP-Seq_VCAP_Human1.20247537
76XRN2_22483619_ChIP-Seq_HELA_Human1.18975827
77EZH2_27294783_Chip-Seq_NPCs_Mouse1.17927235
78RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.15718863
79EZH2_22144423_ChIP-Seq_EOC_Human1.14661409
80* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.14386089
81ETV2_25802403_ChIP-Seq_MESCs_Mouse1.13950876
82SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13623473
83TAL1_26923725_Chip-Seq_HPCs_Mouse1.13406422
84GATA3_26560356_Chip-Seq_TH2_Human1.12104585
85MYC_19030024_ChIP-ChIP_MESCs_Mouse1.10547485
86* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.08751135
87CRX_20693478_ChIP-Seq_RETINA_Mouse1.08496055
88FOXA1_21572438_ChIP-Seq_LNCaP_Human1.08364322
89HTT_18923047_ChIP-ChIP_STHdh_Human1.08197234
90NFE2_27457419_Chip-Seq_LIVER_Mouse1.07947083
91FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.07673624
92MYC_18940864_ChIP-ChIP_HL60_Human1.06661193
93TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05824509
94SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.05621715
95EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.04747144
96SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.03225902
97SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02149305
98PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.01609093
99CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.01270945
100P300_19829295_ChIP-Seq_ESCs_Human1.01201914
101IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.00580850
102CTBP2_25329375_ChIP-Seq_LNCAP_Human1.00426602
103REST_21632747_ChIP-Seq_MESCs_Mouse1.00382118
104P53_22387025_ChIP-Seq_ESCs_Mouse1.00052073
105TTF2_22483619_ChIP-Seq_HELA_Human0.99607764
106EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99579241
107TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98914758
108SOX2_19829295_ChIP-Seq_ESCs_Human0.98781190
109NANOG_19829295_ChIP-Seq_ESCs_Human0.98781190
110NANOG_18555785_Chip-Seq_ESCs_Mouse0.98081416
111* NCOR_22424771_ChIP-Seq_293T_Human0.97703336
112HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.95376628
113SMAD4_21799915_ChIP-Seq_A2780_Human0.94363618
114CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.93864077
115BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.93731278
116TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.93129309
117CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.92252751
118CMYC_18555785_Chip-Seq_ESCs_Mouse0.91882837
119P300_18555785_Chip-Seq_ESCs_Mouse0.91710735
120SUZ12_18555785_Chip-Seq_ESCs_Mouse0.91594445
121STAT3_18555785_Chip-Seq_ESCs_Mouse0.91433492
122NMYC_18555785_Chip-Seq_ESCs_Mouse0.91069692
123TFEB_21752829_ChIP-Seq_HELA_Human0.90856174
124PU1_27457419_Chip-Seq_LIVER_Mouse0.90558011
125KLF5_20875108_ChIP-Seq_MESCs_Mouse0.90514161
126EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.89692223
127OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89676340
128ZFX_18555785_ChIP-Seq_MESCs_Mouse0.89634803
129SOX2_18555785_Chip-Seq_ESCs_Mouse0.89621585
130MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.88830480
131TCF4_22108803_ChIP-Seq_LS180_Human0.88770645
132MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.87192804
133TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.87081120
134CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.86138125
135SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.85950605
136REST_19997604_ChIP-ChIP_NEURONS_Mouse0.85222018
137IGF1R_20145208_ChIP-Seq_DFB_Human0.83769627
138FLI1_27457419_Chip-Seq_LIVER_Mouse0.83650819
139CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.83454872
140GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.81552216
141MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.81518830
142EOMES_21245162_ChIP-Seq_HESCs_Human0.80097245
143PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.79952459
144CTBP1_25329375_ChIP-Seq_LNCAP_Human0.78174227
145* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.77990669
146TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.77922483
147SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.76367386
148* SALL4_22934838_ChIP-ChIP_CD34+_Human0.75401009
149POU3F2_20337985_ChIP-ChIP_501MEL_Human0.75158498
150CBP_20019798_ChIP-Seq_JUKART_Human0.74076140
151IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.74076140
152CIITA_25753668_ChIP-Seq_RAJI_Human0.73931065

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.93434433
2MP0002138_abnormal_hepatobiliary_system3.93323620
3MP0005365_abnormal_bile_salt3.70274934
4MP0005085_abnormal_gallbladder_physiolo3.24065890
5MP0005360_urolithiasis3.11379190
6MP0000372_irregular_coat_pigmentation3.06440997
7MP0008875_abnormal_xenobiotic_pharmacok3.01491408
8MP0003806_abnormal_nucleotide_metabolis2.71238119
9MP0003787_abnormal_imprinting2.68126191
10MP0006036_abnormal_mitochondrial_physio2.63461519
11MP0002102_abnormal_ear_morphology2.47726999
12MP0002837_dystrophic_cardiac_calcinosis2.23812162
13MP0008877_abnormal_DNA_methylation2.22588867
14MP0003195_calcinosis2.19848729
15MP0000569_abnormal_digit_pigmentation2.17438773
16MP0003880_abnormal_central_pattern2.14651123
17MP0002638_abnormal_pupillary_reflex2.12555199
18MP0005646_abnormal_pituitary_gland2.07023352
19MP0005671_abnormal_response_to2.06673511
20MP0001764_abnormal_homeostasis2.05968263
21MP0005408_hypopigmentation2.03909450
22MP0004147_increased_porphyrin_level2.03765568
23MP0002876_abnormal_thyroid_physiology1.98065070
24MP0001188_hyperpigmentation1.96750233
25MP0002909_abnormal_adrenal_gland1.93532003
26MP0010329_abnormal_lipoprotein_level1.93286985
27MP0001968_abnormal_touch/_nociception1.90516326
28MP0003122_maternal_imprinting1.90334925
29MP0002736_abnormal_nociception_after1.89372079
30MP0009785_altered_susceptibility_to1.85220831
31MP0003646_muscle_fatigue1.81658152
32MP0005332_abnormal_amino_acid1.81328163
33MP0001529_abnormal_vocalization1.75957593
34MP0000013_abnormal_adipose_tissue1.75937811
35MP0003879_abnormal_hair_cell1.73420375
36MP0001984_abnormal_olfaction1.71256076
37MP0004859_abnormal_synaptic_plasticity1.69578444
38MP0002064_seizures1.68526718
39MP0003635_abnormal_synaptic_transmissio1.64587316
40MP0005084_abnormal_gallbladder_morpholo1.61774466
41MP0003252_abnormal_bile_duct1.60015065
42MP0003656_abnormal_erythrocyte_physiolo1.58336679
43MP0009697_abnormal_copulation1.58037773
44MP0005584_abnormal_enzyme/coenzyme_acti1.57697673
45MP0009745_abnormal_behavioral_response1.57300129
46MP0001905_abnormal_dopamine_level1.54774271
47MP0002822_catalepsy1.50031506
48MP0009379_abnormal_foot_pigmentation1.48869390
49MP0004142_abnormal_muscle_tone1.47818339
50MP0002272_abnormal_nervous_system1.45360927
51MP0005410_abnormal_fertilization1.43519350
52MP0001986_abnormal_taste_sensitivity1.42193384
53MP0003121_genomic_imprinting1.41933396
54MP0001835_abnormal_antigen_presentation1.41565813
55MP0001666_abnormal_nutrient_absorption1.38969912
56MP0004270_analgesia1.37802191
57MP0003123_paternal_imprinting1.35736385
58MP0006276_abnormal_autonomic_nervous1.34876219
59MP0002572_abnormal_emotion/affect_behav1.33128592
60MP0003186_abnormal_redox_activity1.32096610
61MP0004043_abnormal_pH_regulation1.30783553
62MP0006035_abnormal_mitochondrial_morpho1.30066819
63MP0005075_abnormal_melanosome_morpholog1.28980854
64MP0000015_abnormal_ear_pigmentation1.25939323
65MP0009840_abnormal_foam_cell1.25123101
66MP0005167_abnormal_blood-brain_barrier1.24720050
67MP0000427_abnormal_hair_cycle1.24486848
68MP0005645_abnormal_hypothalamus_physiol1.24169494
69MP0006082_CNS_inflammation1.23183338
70MP0005636_abnormal_mineral_homeostasis1.22177809
71MP0003172_abnormal_lysosome_physiology1.21466540
72MP0009046_muscle_twitch1.21013242
73MP0002063_abnormal_learning/memory/cond1.20838983
74MP0005319_abnormal_enzyme/_coenzyme1.17691351
75MP0002118_abnormal_lipid_homeostasis1.17083499
76MP0002735_abnormal_chemical_nociception1.16868505
77MP0002693_abnormal_pancreas_physiology1.12705492
78MP0003638_abnormal_response/metabolism_1.09500924
79MP0008872_abnormal_physiological_respon1.07339935
80MP0009780_abnormal_chondrocyte_physiolo1.06785616
81MP0004215_abnormal_myocardial_fiber1.06592043
82MP0004782_abnormal_surfactant_physiolog1.05098010
83MP0002295_abnormal_pulmonary_circulatio1.02159395
84MP0009764_decreased_sensitivity_to1.01797597
85MP0001501_abnormal_sleep_pattern1.01756924
86MP0005083_abnormal_biliary_tract1.01476291
87MP0005535_abnormal_body_temperature1.01170025
88MP0003183_abnormal_peptide_metabolism1.00991041
89MP0005000_abnormal_immune_tolerance0.98910898
90* MP0002078_abnormal_glucose_homeostasis0.98310671
91MP0005464_abnormal_platelet_physiology0.95717150
92MP0005025_abnormal_response_to0.94347010
93MP0008004_abnormal_stomach_pH0.94337176
94MP0000230_abnormal_systemic_arterial0.94177734
95MP0001177_atelectasis0.92472349
96MP0001440_abnormal_grooming_behavior0.90757431
97MP0001765_abnormal_ion_homeostasis0.90509932
98MP0005379_endocrine/exocrine_gland_phen0.89967069
99MP0002734_abnormal_mechanical_nocicepti0.89558529
100MP0003191_abnormal_cellular_cholesterol0.89133692
101MP0010386_abnormal_urinary_bladder0.88950809
102MP0001486_abnormal_startle_reflex0.88740964
103MP0001845_abnormal_inflammatory_respons0.88472630
104MP0001502_abnormal_circadian_rhythm0.88467927
105MP0003868_abnormal_feces_composition0.88460478
106MP0002166_altered_tumor_susceptibility0.88185047
107MP0009643_abnormal_urine_homeostasis0.88054934
108MP0000751_myopathy0.88015742
109MP0005058_abnormal_lysosome_morphology0.87583692
110MP0005551_abnormal_eye_electrophysiolog0.87472155
111MP0008874_decreased_physiological_sensi0.86392764
112MP0001664_abnormal_digestion0.86123078
113MP0005253_abnormal_eye_physiology0.86031839
114MP0001756_abnormal_urination0.86028996
115MP0005376_homeostasis/metabolism_phenot0.85825503
116MP0002067_abnormal_sensory_capabilities0.85532039
117MP0004130_abnormal_muscle_cell0.85189758
118MP0005266_abnormal_metabolism0.84557396
119MP0005220_abnormal_exocrine_pancreas0.84510262
120MP0008569_lethality_at_weaning0.84316697
121MP0000749_muscle_degeneration0.84228303
122MP0005670_abnormal_white_adipose0.83266049
123MP0006072_abnormal_retinal_apoptosis0.83204417
124MP0003329_amyloid_beta_deposits0.81787065
125MP0004233_abnormal_muscle_weight0.80728994
126MP0001790_abnormal_immune_system0.80475362
127MP0005387_immune_system_phenotype0.80475362
128MP0001346_abnormal_lacrimal_gland0.80333682
129MP0004145_abnormal_muscle_electrophysio0.80189671
130MP0003959_abnormal_lean_body0.80069524
131MP0003724_increased_susceptibility_to0.79998878
132MP0002148_abnormal_hypersensitivity_rea0.79938520
133MP0000639_abnormal_adrenal_gland0.79700497
134MP0000609_abnormal_liver_physiology0.78570706
135MP0002733_abnormal_thermal_nociception0.78112988
136MP0005386_behavior/neurological_phenoty0.77959937
137MP0004924_abnormal_behavior0.77959937
138MP0001270_distended_abdomen0.77541500
139MP0004019_abnormal_vitamin_homeostasis0.76235639
140MP0003953_abnormal_hormone_level0.74928296
141MP0005174_abnormal_tail_pigmentation0.74308719
142MP0005423_abnormal_somatic_nervous0.73187098
143MP0001661_extended_life_span0.72995613
144MP0002095_abnormal_skin_pigmentation0.72127837
145MP0008789_abnormal_olfactory_epithelium0.71717930
146MP0002723_abnormal_immune_serum0.70989692
147MP0009642_abnormal_blood_homeostasis0.69886538
148MP0001970_abnormal_pain_threshold0.69078903

Predicted human phenotypes

RankGene SetZ-score
1Hepatocellular necrosis (HP:0001404)4.94350952
2Hepatic necrosis (HP:0002605)4.60180851
3Abnormal mitochondria in muscle tissue (HP:0008316)4.47094053
4Acute necrotizing encephalopathy (HP:0006965)4.36148474
5Mitochondrial inheritance (HP:0001427)4.31531766
6Acute encephalopathy (HP:0006846)4.25163884
7Abnormality of aromatic amino acid family metabolism (HP:0004338)4.24916535
8Increased CSF lactate (HP:0002490)4.09213401
9Increased serum pyruvate (HP:0003542)3.68011069
10Abnormality of glycolysis (HP:0004366)3.68011069
11Progressive macrocephaly (HP:0004481)3.57676391
12Decreased activity of mitochondrial respiratory chain (HP:0008972)3.56698689
13Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.56698689
14Cerebral edema (HP:0002181)3.45804632
15Lactic acidosis (HP:0003128)3.45376654
16Increased serum lactate (HP:0002151)3.24022833
17Ragged-red muscle fibers (HP:0003200)3.22567757
18Abnormal gallbladder physiology (HP:0012438)3.21408385
19Cholecystitis (HP:0001082)3.21408385
20Ketosis (HP:0001946)3.15390273
21Intrahepatic cholestasis (HP:0001406)3.06532952
22Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.01996271
23Increased intramyocellular lipid droplets (HP:0012240)3.00255842
24Increased muscle lipid content (HP:0009058)2.97404404
25Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.95406240
26Renal Fanconi syndrome (HP:0001994)2.94471529
27Hypobetalipoproteinemia (HP:0003563)2.87410640
28Exercise intolerance (HP:0003546)2.85028516
29Neuroendocrine neoplasm (HP:0100634)2.83790250
30Dry hair (HP:0011359)2.82696643
31Lipid accumulation in hepatocytes (HP:0006561)2.81854855
32Respiratory failure (HP:0002878)2.80953338
33Pheochromocytoma (HP:0002666)2.80606979
34CNS demyelination (HP:0007305)2.77953615
35Methylmalonic aciduria (HP:0012120)2.74272468
36Lethargy (HP:0001254)2.66383498
37Increased hepatocellular lipid droplets (HP:0006565)2.64434580
38Leukodystrophy (HP:0002415)2.63274202
39Hyperammonemia (HP:0001987)2.62826476
40Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.62006177
41Abnormality of fatty-acid metabolism (HP:0004359)2.58410799
42Medial flaring of the eyebrow (HP:0010747)2.54909840
43Hyperventilation (HP:0002883)2.53665129
44Abnormal hair whorl (HP:0010721)2.53565965
45Poor suck (HP:0002033)2.49622571
46Ketoacidosis (HP:0001993)2.47432262
47Abnormality of monocarboxylic acid metabolism (HP:0010996)2.47022686
48Aplastic anemia (HP:0001915)2.46566260
49Degeneration of anterior horn cells (HP:0002398)2.45715485
50Abnormality of the anterior horn cell (HP:0006802)2.45715485
51Hyperglycinemia (HP:0002154)2.45695053
52Abnormal pupillary function (HP:0007686)2.45201678
53Focal motor seizures (HP:0011153)2.45192852
54Emotional lability (HP:0000712)2.43620036
55Atrophy/Degeneration involving motor neurons (HP:0007373)2.43537131
56Oligomenorrhea (HP:0000876)2.43325899
57Abnormality of dicarboxylic acid metabolism (HP:0010995)2.42505156
58Dicarboxylic aciduria (HP:0003215)2.42505156
59Methylmalonic acidemia (HP:0002912)2.41822602
60Abnormality of alanine metabolism (HP:0010916)2.36697810
61Hyperalaninemia (HP:0003348)2.36697810
62Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.36697810
63Myokymia (HP:0002411)2.35691663
64Abnormality of the heme biosynthetic pathway (HP:0010472)2.31297735
65Opisthotonus (HP:0002179)2.28806522
66Generalized aminoaciduria (HP:0002909)2.24345594
67Renal cortical cysts (HP:0000803)2.22206393
68Gait imbalance (HP:0002141)2.21034318
69Abnormality of serum amino acid levels (HP:0003112)2.20866951
70Neoplasm of head and neck (HP:0012288)2.19580539
71Esophageal neoplasm (HP:0100751)2.19580539
72Cerebral hypomyelination (HP:0006808)2.19075173
73Microvesicular hepatic steatosis (HP:0001414)2.18864080
74Progressive microcephaly (HP:0000253)2.18457220
75Hypoglycemic coma (HP:0001325)2.16205344
76Deep venous thrombosis (HP:0002625)2.15905982
77Metabolic acidosis (HP:0001942)2.15687580
78Gliosis (HP:0002171)2.15167550
79Congenital primary aphakia (HP:0007707)2.14209166
80Optic disc pallor (HP:0000543)2.09686108
81Abnormality of endocrine pancreas physiology (HP:0012093)2.08563958
82Abnormality of the pancreatic islet cells (HP:0006476)2.08563958
83Epileptic encephalopathy (HP:0200134)2.08122176
84Neoplasm of the peripheral nervous system (HP:0100007)2.06879082
85Hyperbilirubinemia (HP:0002904)2.05612095
86Delusions (HP:0000746)2.05119279
87Ankle clonus (HP:0011448)2.04716773
88Abnormality of urine glucose concentration (HP:0011016)2.04453474
89Glycosuria (HP:0003076)2.04453474
90Nephrogenic diabetes insipidus (HP:0009806)2.03944683
91Gout (HP:0001997)2.01997716
92Absent speech (HP:0001344)2.00717809
93Vomiting (HP:0002013)2.00560233
94Progressive inability to walk (HP:0002505)2.00014577
95Amyotrophic lateral sclerosis (HP:0007354)1.98537253
96Hyperlipoproteinemia (HP:0010980)1.97391481
97Prolonged partial thromboplastin time (HP:0003645)1.95277440
98Abnormality of renal resorption (HP:0011038)1.95021462
99Hyperphosphaturia (HP:0003109)1.94674603
100Acute hepatic failure (HP:0006554)1.94439156
101Thyroid-stimulating hormone excess (HP:0002925)1.94052942
102Xanthomatosis (HP:0000991)1.93882212
103Cholelithiasis (HP:0001081)1.93507997
104Abnormal gallbladder morphology (HP:0012437)1.91932484
105Respiratory difficulties (HP:0002880)1.91726357
1063-Methylglutaconic aciduria (HP:0003535)1.91716893
107Atonic seizures (HP:0010819)1.90961821
108Abnormality of methionine metabolism (HP:0010901)1.90081006
109Reduced antithrombin III activity (HP:0001976)1.89825772
110Hypothermia (HP:0002045)1.89314746
111Complement deficiency (HP:0004431)1.89183854
112Delayed CNS myelination (HP:0002188)1.88763357
113Type I transferrin isoform profile (HP:0003642)1.88701224
114Abnormality of aspartate family amino acid metabolism (HP:0010899)1.88666523
115Abnormal protein glycosylation (HP:0012346)1.88070879
116Abnormal glycosylation (HP:0012345)1.88070879
117Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.88070879
118Abnormal protein N-linked glycosylation (HP:0012347)1.88070879
119Muscular hypotonia of the trunk (HP:0008936)1.87923481
120Intention tremor (HP:0002080)1.87606574
121Inability to walk (HP:0002540)1.87330022
122Metaphyseal dysplasia (HP:0100255)1.85206549
123Hypoproteinemia (HP:0003075)1.84324875
124Type II lissencephaly (HP:0007260)1.84222686
125Polyphagia (HP:0002591)1.83901041
126Exertional dyspnea (HP:0002875)1.82848076
127Tongue fasciculations (HP:0001308)1.82613470
128* Brushfield spots (HP:0001088)1.82346997
129Hypsarrhythmia (HP:0002521)1.81542883
130Epileptiform EEG discharges (HP:0011182)1.79287875
131Hypercholesterolemia (HP:0003124)1.78015933
132EEG with generalized epileptiform discharges (HP:0011198)1.78000158
133Abnormality of the renal cortex (HP:0011035)1.76574410
134Abnormal neuron morphology (HP:0012757)1.75503721
135Abnormality of the motor neurons (HP:0002450)1.75503721
136Abnormal biliary tract physiology (HP:0012439)1.74970050
137Large for gestational age (HP:0001520)1.73446088
138Eosinophilia (HP:0001880)1.73288616
139Petechiae (HP:0000967)1.72866962
140Papilledema (HP:0001085)1.72153147
141Aplasia/hypoplasia of the uterus (HP:0008684)1.69376288
142Granulocytopenia (HP:0001913)1.69180293
143Generalized hypopigmentation (HP:0007513)1.68573381
144Hypokinesia (HP:0002375)1.67693353
145Conjunctival hamartoma (HP:0100780)1.67414064
146Abnormality of lateral ventricle (HP:0030047)1.67370767
147Abnormality of dental color (HP:0011073)1.67256777
148Limb dystonia (HP:0002451)1.66733809
149Hyperinsulinemic hypoglycemia (HP:0000825)1.63375594
150Hypoglycemic seizures (HP:0002173)1.63157096

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K23.66175896
2MAP3K123.65829815
3TRIM283.60907462
4ARAF3.29674307
5MST43.17325677
6CASK3.16248434
7CDK192.99842313
8LIMK12.92701098
9EPHA32.77457636
10BCKDK2.75674288
11EIF2AK12.63965844
12MAP2K72.57181246
13PIM22.56018811
14CCNB12.52299182
15SIK32.38937092
16STK162.30887291
17BRAF2.28979324
18MAP2K42.19207212
19PLK22.15451383
20PDK32.15064579
21PDK42.15064579
22AKT31.93986777
23MAP3K111.81142471
24DAPK11.72749728
25ACVR1B1.67961271
26BCR1.66237277
27MAP3K41.65869511
28ERBB31.64029799
29MYLK1.61102892
30CSNK1G11.58256001
31CDK81.52299925
32TSSK61.49247582
33TEC1.46302625
34KIT1.37368556
35NME11.36350032
36MAP3K61.35966171
37BUB11.31585503
38WEE11.27751618
39CSNK1G21.27234463
40MAPKAPK51.26195423
41PAK31.25574238
42PRKCE1.24390018
43DAPK21.24121384
44OXSR11.23632291
45PTK2B1.22852281
46NEK91.20979615
47NME21.20703572
48CSNK1A1L1.20223882
49BMPR1B1.14071908
50MINK11.13575015
51PIK3CG1.12837946
52TESK21.12571548
53MAP2K31.12485332
54INSRR1.10817691
55NUAK11.10695804
56TLK11.10398222
57GRK11.06461838
58FRK1.05521009
59STK38L1.05191192
60RAF11.04581995
61VRK11.04073133
62NTRK31.01169093
63ZAK1.00182421
64WNK40.97917250
65CDK30.93890614
66WNK30.91216871
67IKBKE0.89322650
68STK240.88224967
69MAPK150.84893553
70PRKCG0.84466574
71EPHA40.81937077
72CAMK2G0.80229027
73BMPR20.78284223
74TESK10.77589603
75MAPKAPK30.76258198
76VRK20.75336839
77MAP2K60.74991786
78SCYL20.74658289
79FER0.74479959
80CAMKK20.74003847
81FES0.73504271
82IRAK40.72523530
83TIE10.72335514
84ADRBK20.71102466
85CDK140.68652672
86CAMK2A0.68419019
87EIF2AK30.67024013
88PAK60.64740019
89PDK20.64731257
90ADRBK10.62927608
91PRKCQ0.62266229
92STK390.61796013
93MAP3K10.61411035
94MAP4K10.61086780
95RIPK40.60800571
96CDK180.60780434
97MAP3K50.59686761
98FLT30.59661814
99MATK0.59603016
100PRKCI0.59131521
101DAPK30.58439303
102TAOK30.58084372
103CDK150.57316274
104CDK11A0.56705575
105CSF1R0.56529599
106FGFR20.56172751
107GRK70.56011723
108GRK50.54201841
109CAMK2B0.52636748
110CSNK1A10.52291368
111TXK0.52280734
112PINK10.51835302
113TYK20.51694913
114PLK40.51623344
115PHKG20.51563498
116PHKG10.51563498
117DYRK20.51095598
118TBK10.50870010
119UHMK10.49052501
120MARK30.48779708
121MAP3K130.48429105
122IKBKB0.45844908
123ABL20.45564300
124MARK10.44889514
125IGF1R0.44768574
126MAPK130.44385340
127PIK3CA0.43674115
128JAK10.43631674
129LYN0.43130880
130MUSK0.42615096
131RPS6KA40.42414991
132SIK20.41284328
133JAK20.40135029
134MAP3K90.38290652
135ABL10.38164008
136KDR0.37843066
137ERBB40.37215790
138MAPK110.35791543
139CDK50.35068290
140PRKACA0.34690697
141ZAP700.33548920
142MAPK40.33285861
143SGK4940.33010297
144SGK2230.33010297
145CSNK1D0.32787526
146CSNK1G30.32044000
147AURKA0.31825556
148NEK10.31436098
149SYK0.31221077
150TNK20.31035633
151PRKD30.29989259
152PASK0.29196663

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.28599535
2Oxidative phosphorylation_Homo sapiens_hsa001903.16960369
3Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.72493961
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.67288851
5Parkinsons disease_Homo sapiens_hsa050122.65996262
6Pyruvate metabolism_Homo sapiens_hsa006202.60405357
7Propanoate metabolism_Homo sapiens_hsa006402.58372124
8Primary bile acid biosynthesis_Homo sapiens_hsa001202.54662596
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.25088570
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.20379121
11Fatty acid degradation_Homo sapiens_hsa000712.04527759
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.01808380
13Alzheimers disease_Homo sapiens_hsa050101.92436080
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.89937600
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.89422252
16Carbon metabolism_Homo sapiens_hsa012001.84276009
17Proteasome_Homo sapiens_hsa030501.83990751
18Cysteine and methionine metabolism_Homo sapiens_hsa002701.82233837
19Protein export_Homo sapiens_hsa030601.78370854
20Fatty acid elongation_Homo sapiens_hsa000621.77791392
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.76145152
22Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.71713370
23Huntingtons disease_Homo sapiens_hsa050161.68863682
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.62454187
25Primary immunodeficiency_Homo sapiens_hsa053401.60797993
26Arginine biosynthesis_Homo sapiens_hsa002201.59982214
27* Peroxisome_Homo sapiens_hsa041461.56455346
28Butanoate metabolism_Homo sapiens_hsa006501.56165781
29Regulation of autophagy_Homo sapiens_hsa041401.54998826
30Tryptophan metabolism_Homo sapiens_hsa003801.54724569
31beta-Alanine metabolism_Homo sapiens_hsa004101.48547114
32Synaptic vesicle cycle_Homo sapiens_hsa047211.44982083
33Fatty acid metabolism_Homo sapiens_hsa012121.42255416
34Biosynthesis of amino acids_Homo sapiens_hsa012301.41171463
35Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.40263109
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.39110102
37Ribosome_Homo sapiens_hsa030101.38572081
38Collecting duct acid secretion_Homo sapiens_hsa049661.38466003
39Folate biosynthesis_Homo sapiens_hsa007901.35425090
40Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.33118963
41Type I diabetes mellitus_Homo sapiens_hsa049401.30853000
42Rheumatoid arthritis_Homo sapiens_hsa053231.28663321
43Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.21554095
44Vitamin B6 metabolism_Homo sapiens_hsa007501.19335011
45Cardiac muscle contraction_Homo sapiens_hsa042601.18687866
46RNA polymerase_Homo sapiens_hsa030201.17130299
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.16062895
48Pentose phosphate pathway_Homo sapiens_hsa000301.15528287
49Graft-versus-host disease_Homo sapiens_hsa053321.14421752
50Histidine metabolism_Homo sapiens_hsa003401.14379182
51Nicotine addiction_Homo sapiens_hsa050331.12934320
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.09488825
53Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.08557370
54Phenylalanine metabolism_Homo sapiens_hsa003601.08019895
55Pentose and glucuronate interconversions_Homo sapiens_hsa000401.04315890
56Tyrosine metabolism_Homo sapiens_hsa003500.99044963
57Vibrio cholerae infection_Homo sapiens_hsa051100.98474139
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.97170582
59Allograft rejection_Homo sapiens_hsa053300.92708527
60DNA replication_Homo sapiens_hsa030300.91655885
61Sulfur metabolism_Homo sapiens_hsa009200.91359668
62Cyanoamino acid metabolism_Homo sapiens_hsa004600.91034630
63Pyrimidine metabolism_Homo sapiens_hsa002400.90458991
64Metabolic pathways_Homo sapiens_hsa011000.89529975
65Autoimmune thyroid disease_Homo sapiens_hsa053200.89219648
66Selenocompound metabolism_Homo sapiens_hsa004500.88324303
67Complement and coagulation cascades_Homo sapiens_hsa046100.86802447
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86674471
69Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.85370248
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84431610
71Drug metabolism - other enzymes_Homo sapiens_hsa009830.82314885
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.81757243
73PPAR signaling pathway_Homo sapiens_hsa033200.81698564
74Phototransduction_Homo sapiens_hsa047440.81231802
75Asthma_Homo sapiens_hsa053100.80870095
76Chemical carcinogenesis_Homo sapiens_hsa052040.80616542
77Sulfur relay system_Homo sapiens_hsa041220.80243207
78Intestinal immune network for IgA production_Homo sapiens_hsa046720.79851069
79Glycosaminoglycan degradation_Homo sapiens_hsa005310.79838175
80Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.76503193
81Circadian rhythm_Homo sapiens_hsa047100.76096388
82GABAergic synapse_Homo sapiens_hsa047270.72660812
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.72598370
84Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.72177846
85Maturity onset diabetes of the young_Homo sapiens_hsa049500.72161470
86Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70793151
87Basal transcription factors_Homo sapiens_hsa030220.68673175
88Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.68283807
89Purine metabolism_Homo sapiens_hsa002300.67112764
90Sphingolipid metabolism_Homo sapiens_hsa006000.67067910
91Antigen processing and presentation_Homo sapiens_hsa046120.66310298
92Glutathione metabolism_Homo sapiens_hsa004800.65864206
93Lysosome_Homo sapiens_hsa041420.64688007
94Amphetamine addiction_Homo sapiens_hsa050310.64610258
95N-Glycan biosynthesis_Homo sapiens_hsa005100.63282526
96Arginine and proline metabolism_Homo sapiens_hsa003300.62415213
97Base excision repair_Homo sapiens_hsa034100.61246117
98Phagosome_Homo sapiens_hsa041450.60581635
99Fructose and mannose metabolism_Homo sapiens_hsa000510.57441941
100Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.55169801
101Nitrogen metabolism_Homo sapiens_hsa009100.54720021
102Retinol metabolism_Homo sapiens_hsa008300.54585918
103Circadian entrainment_Homo sapiens_hsa047130.53992779
104Renin-angiotensin system_Homo sapiens_hsa046140.53636969
105Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.53065656
106Hematopoietic cell lineage_Homo sapiens_hsa046400.52946525
107Caffeine metabolism_Homo sapiens_hsa002320.52288752
108Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.49212960
109Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48142273
110ABC transporters_Homo sapiens_hsa020100.46070569
111Starch and sucrose metabolism_Homo sapiens_hsa005000.45676799
112Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.44969218
113Bile secretion_Homo sapiens_hsa049760.43815074
114RNA degradation_Homo sapiens_hsa030180.43558090
115Morphine addiction_Homo sapiens_hsa050320.42355727
116Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.41820265
117Glucagon signaling pathway_Homo sapiens_hsa049220.41423099
118Salivary secretion_Homo sapiens_hsa049700.40855068
119Homologous recombination_Homo sapiens_hsa034400.40257599
120Linoleic acid metabolism_Homo sapiens_hsa005910.39287694
121Galactose metabolism_Homo sapiens_hsa000520.38570838
122Dopaminergic synapse_Homo sapiens_hsa047280.38526886
123Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38045065
124One carbon pool by folate_Homo sapiens_hsa006700.37251928
125Shigellosis_Homo sapiens_hsa051310.37186874
126Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.36066701
127Mismatch repair_Homo sapiens_hsa034300.34890458
128Glycerolipid metabolism_Homo sapiens_hsa005610.34824181
129Cocaine addiction_Homo sapiens_hsa050300.34351377
130Nucleotide excision repair_Homo sapiens_hsa034200.32193666
131Calcium signaling pathway_Homo sapiens_hsa040200.31671273
132Insulin secretion_Homo sapiens_hsa049110.30537247
133Long-term potentiation_Homo sapiens_hsa047200.29767036
134Vitamin digestion and absorption_Homo sapiens_hsa049770.29276656

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