PER2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers and have been linked to sleep disorders. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratinocyte development (GO:0003334)4.71967207
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.55838094
3L-phenylalanine catabolic process (GO:0006559)4.55838094
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.27131226
5L-phenylalanine metabolic process (GO:0006558)4.27131226
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.15648282
7alpha-linolenic acid metabolic process (GO:0036109)4.06511870
8aromatic amino acid family catabolic process (GO:0009074)3.92164497
9water-soluble vitamin biosynthetic process (GO:0042364)3.83674477
10axoneme assembly (GO:0035082)3.80022904
11lysine catabolic process (GO:0006554)3.68177979
12lysine metabolic process (GO:0006553)3.68177979
13high-density lipoprotein particle remodeling (GO:0034375)3.66945510
14bile acid biosynthetic process (GO:0006699)3.66369286
15kynurenine metabolic process (GO:0070189)3.52093786
16positive regulation of fatty acid beta-oxidation (GO:0032000)3.49295309
17regulation of cholesterol homeostasis (GO:2000188)3.44540078
18reverse cholesterol transport (GO:0043691)3.41773424
19respiratory chain complex IV assembly (GO:0008535)3.41657494
20indole-containing compound catabolic process (GO:0042436)3.38568308
21indolalkylamine catabolic process (GO:0046218)3.38568308
22tryptophan catabolic process (GO:0006569)3.38568308
23urea metabolic process (GO:0019627)3.37430017
24urea cycle (GO:0000050)3.37430017
25fucose catabolic process (GO:0019317)3.36255214
26L-fucose metabolic process (GO:0042354)3.36255214
27L-fucose catabolic process (GO:0042355)3.36255214
28tryptophan metabolic process (GO:0006568)3.35290676
29dicarboxylic acid biosynthetic process (GO:0043650)3.34800449
30regulation of triglyceride catabolic process (GO:0010896)3.31567565
31response to pheromone (GO:0019236)3.31285122
32fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.31174837
33cysteine metabolic process (GO:0006534)3.28994084
34protein polyglutamylation (GO:0018095)3.28359500
35negative regulation of fibrinolysis (GO:0051918)3.28256591
36peptidyl-glutamic acid carboxylation (GO:0017187)3.27698895
37protein carboxylation (GO:0018214)3.27698895
38epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.27511614
39amino-acid betaine metabolic process (GO:0006577)3.26142046
40regulation of hexokinase activity (GO:1903299)3.25818699
41regulation of glucokinase activity (GO:0033131)3.25818699
42sulfur amino acid catabolic process (GO:0000098)3.23842552
43glutamate metabolic process (GO:0006536)3.23688644
44bile acid metabolic process (GO:0008206)3.23086219
45auditory receptor cell differentiation (GO:0042491)3.22826536
46regulation of bile acid biosynthetic process (GO:0070857)3.22525077
47complement activation, alternative pathway (GO:0006957)3.22416296
48triglyceride homeostasis (GO:0070328)3.21122382
49acylglycerol homeostasis (GO:0055090)3.21122382
50indolalkylamine metabolic process (GO:0006586)3.20679760
51platelet dense granule organization (GO:0060155)3.19564347
52positive regulation of fatty acid oxidation (GO:0046321)3.19561640
532-oxoglutarate metabolic process (GO:0006103)3.19069774
54protein-lipid complex remodeling (GO:0034368)3.19022919
55macromolecular complex remodeling (GO:0034367)3.19022919
56plasma lipoprotein particle remodeling (GO:0034369)3.19022919
57positive regulation of meiosis (GO:0045836)3.19002090
58glyoxylate metabolic process (GO:0046487)3.17130464
59ketone body metabolic process (GO:1902224)3.16248900
60drug catabolic process (GO:0042737)3.14278486
61positive regulation of meiotic cell cycle (GO:0051446)3.14122665
62regulation of protein activation cascade (GO:2000257)3.12320137
63protein localization to cilium (GO:0061512)3.10953469
64negative regulation of execution phase of apoptosis (GO:1900118)3.10070915
65regulation of fibrinolysis (GO:0051917)3.08490895
66phospholipid homeostasis (GO:0055091)3.08444271
67regulation of acrosome reaction (GO:0060046)3.08306998
68epithelial cilium movement (GO:0003351)3.07738175
69homocysteine metabolic process (GO:0050667)3.07212454
70S-adenosylmethionine metabolic process (GO:0046500)3.05661150
71positive regulation of lipid catabolic process (GO:0050996)3.04208487
72nitrogen cycle metabolic process (GO:0071941)3.03716932
73regulation of meiosis I (GO:0060631)3.02592524
74flavonoid metabolic process (GO:0009812)3.02129642
75cellular response to ATP (GO:0071318)2.99181864
76piRNA metabolic process (GO:0034587)2.99108228
77cytochrome complex assembly (GO:0017004)2.98801410
78cellular glucuronidation (GO:0052695)2.98707183
79adaptation of signaling pathway (GO:0023058)2.96838077
803-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.96498279
81purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.96498279
82regulation of complement activation (GO:0030449)2.95422373
83negative regulation of lipase activity (GO:0060192)2.95283462
84phospholipid efflux (GO:0033700)2.95063008
85tyrosine metabolic process (GO:0006570)2.93319346
86glycerophospholipid catabolic process (GO:0046475)2.92476996
87cellular biogenic amine catabolic process (GO:0042402)2.91873748
88amine catabolic process (GO:0009310)2.91873748
89regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.91602209
90positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.91602209
91regulation of triglyceride biosynthetic process (GO:0010866)2.90555024
92protein K11-linked deubiquitination (GO:0035871)2.90071619
93regulation of cell proliferation involved in kidney development (GO:1901722)2.90053154
94cellular modified amino acid catabolic process (GO:0042219)2.89623445
95fatty acid transmembrane transport (GO:1902001)2.89368088
96short-chain fatty acid metabolic process (GO:0046459)2.89032831
97cellular ketone body metabolic process (GO:0046950)2.88384647
98negative regulation of sterol transport (GO:0032372)2.88331032
99negative regulation of cholesterol transport (GO:0032375)2.88331032
100alpha-amino acid catabolic process (GO:1901606)2.87685313
101detection of light stimulus involved in visual perception (GO:0050908)2.86321742
102detection of light stimulus involved in sensory perception (GO:0050962)2.86321742
103positive regulation of glomerulus development (GO:0090193)2.85604199
104cornea development in camera-type eye (GO:0061303)2.84579217
105polyol catabolic process (GO:0046174)2.83244540
106regulation of cholesterol esterification (GO:0010872)2.82724586
107plasma lipoprotein particle clearance (GO:0034381)2.82514754
108regulation of fatty acid beta-oxidation (GO:0031998)2.80389978
109serine family amino acid catabolic process (GO:0009071)2.79329980
110valine metabolic process (GO:0006573)2.79210628
111positive regulation of protein autophosphorylation (GO:0031954)2.79041954
112cholesterol efflux (GO:0033344)2.78792475
113fatty acid beta-oxidation (GO:0006635)2.78685889
114regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.78238145
115regulation of triglyceride metabolic process (GO:0090207)2.77870726
116fatty acid oxidation (GO:0019395)2.77705122
117carnitine metabolic process (GO:0009437)2.77459654
118lipid oxidation (GO:0034440)2.75614907
119exogenous drug catabolic process (GO:0042738)2.74535592
120preassembly of GPI anchor in ER membrane (GO:0016254)2.74057385
121positive regulation of triglyceride metabolic process (GO:0090208)2.73354730
122cilium movement (GO:0003341)2.73057680
123aromatic amino acid family metabolic process (GO:0009072)2.72221994
124cellular amino acid catabolic process (GO:0009063)2.71423957
125prostate gland growth (GO:0060736)2.70610478
126carnitine shuttle (GO:0006853)2.69782636
127aspartate family amino acid catabolic process (GO:0009068)2.69114227
128monocarboxylic acid catabolic process (GO:0072329)2.69094091
129negative regulation of cytosolic calcium ion concentration (GO:0051481)2.69093945
130intestinal cholesterol absorption (GO:0030299)2.67034161
131multicellular organism reproduction (GO:0032504)2.66859938
132protein K6-linked ubiquitination (GO:0085020)2.66135691
133retinal cone cell development (GO:0046549)2.65964303
134detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.65478279
135negative regulation of complement activation (GO:0045916)2.65372851
136benzene-containing compound metabolic process (GO:0042537)2.65302630
137behavioral response to nicotine (GO:0035095)2.65268502
138fatty acid catabolic process (GO:0009062)2.64479820
139bile acid and bile salt transport (GO:0015721)2.63145662
140regulation of glomerulus development (GO:0090192)2.60403258
141DNA deamination (GO:0045006)2.59877241
142plasma lipoprotein particle assembly (GO:0034377)2.59348696
143positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.59282997
144regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.59282997
145estrogen metabolic process (GO:0008210)2.58352536
146negative regulation of JUN kinase activity (GO:0043508)2.58175877
147positive regulation of fatty acid metabolic process (GO:0045923)2.57885980
148positive regulation of triglyceride biosynthetic process (GO:0010867)2.57867182
149photoreceptor cell maintenance (GO:0045494)2.57277358
150sterol catabolic process (GO:0016127)2.56865771
151cholesterol catabolic process (GO:0006707)2.56865771
152negative regulation of dendrite development (GO:2000171)2.56513222
153cilium morphogenesis (GO:0060271)2.55144322
154positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.55075844
155cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.54327687
156cilium organization (GO:0044782)2.54225468
157kidney morphogenesis (GO:0060993)2.52882236
158regulation of fatty acid oxidation (GO:0046320)2.52877196
159inositol phosphate catabolic process (GO:0071545)2.52474177
160drug metabolic process (GO:0017144)2.52342260
161plasma lipoprotein particle organization (GO:0071827)2.52112700
162drug transmembrane transport (GO:0006855)2.51153874
163regulation of action potential (GO:0098900)2.50729365
164organic acid catabolic process (GO:0016054)2.50281723
165carboxylic acid catabolic process (GO:0046395)2.50281723
166uronic acid metabolic process (GO:0006063)2.49691085
167glucuronate metabolic process (GO:0019585)2.49691085
168endocrine pancreas development (GO:0031018)2.49141788
169reflex (GO:0060004)2.48629628
170alanine transport (GO:0032328)2.48067003
171indole-containing compound metabolic process (GO:0042430)2.46778204
172regulation of cilium movement (GO:0003352)2.45568171
173GPI anchor metabolic process (GO:0006505)2.45274552
174intraciliary transport (GO:0042073)2.43414548
175cilium assembly (GO:0042384)2.42851235
176sphingomyelin metabolic process (GO:0006684)2.42627768
177proline transport (GO:0015824)2.42056680
178smooth muscle tissue development (GO:0048745)2.40989558
179phenylpropanoid metabolic process (GO:0009698)2.38068341
180embryonic epithelial tube formation (GO:0001838)2.36802088
181nephron tubule formation (GO:0072079)2.36193992
182DNA methylation involved in gamete generation (GO:0043046)2.35882995
183xenobiotic catabolic process (GO:0042178)2.35315332
184transepithelial transport (GO:0070633)2.34365713
185regulation of protein glycosylation (GO:0060049)2.33987648
186dentate gyrus development (GO:0021542)2.33772091
187gamma-aminobutyric acid transport (GO:0015812)2.33142503
188insulin secretion (GO:0030073)2.32800894
189positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.31205947
190dopamine transport (GO:0015872)2.30864148
191negative regulation of protein activation cascade (GO:2000258)2.29201313
192organic cation transport (GO:0015695)2.28263098

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.48498788
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.74250469
3* RXR_22158963_ChIP-Seq_LIVER_Mouse4.15111807
4* LXR_22158963_ChIP-Seq_LIVER_Mouse3.56760535
5* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.39808780
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.02117758
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.98972632
8ZNF274_21170338_ChIP-Seq_K562_Hela2.88084993
9* NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.77515525
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.63779234
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.59671581
12EZH2_22144423_ChIP-Seq_EOC_Human2.54533888
13VDR_22108803_ChIP-Seq_LS180_Human2.51204770
14EGR1_23403033_ChIP-Seq_LIVER_Mouse2.42157111
15GATA1_22025678_ChIP-Seq_K562_Human2.39531538
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.27739999
17FUS_26573619_Chip-Seq_HEK293_Human2.09378370
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.05029007
19P300_19829295_ChIP-Seq_ESCs_Human2.02250462
20FLI1_27457419_Chip-Seq_LIVER_Mouse1.98805393
21BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.94367694
22DROSHA_22980978_ChIP-Seq_HELA_Human1.90922757
23TAF15_26573619_Chip-Seq_HEK293_Human1.85302115
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.78627910
25EWS_26573619_Chip-Seq_HEK293_Human1.76434337
26ER_23166858_ChIP-Seq_MCF-7_Human1.75436596
27SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.72138647
28IGF1R_20145208_ChIP-Seq_DFB_Human1.67971104
29PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.64387750
30GBX2_23144817_ChIP-Seq_PC3_Human1.62213900
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.60560506
32SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.59268653
33MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.58202822
34PCGF2_27294783_Chip-Seq_ESCs_Mouse1.57704754
35SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.57273998
36* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.57077920
37IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.55524023
38CBP_20019798_ChIP-Seq_JUKART_Human1.55524023
39FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.54597107
40EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.53334538
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53124306
42* EZH2_27294783_Chip-Seq_NPCs_Mouse1.51511668
43* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.50897530
44* FOXA2_19822575_ChIP-Seq_HepG2_Human1.50783301
45* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.50231284
46SMAD3_21741376_ChIP-Seq_EPCs_Human1.50098785
47* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.50090985
48* CLOCK_20551151_ChIP-Seq_293T_Human1.48231338
49UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.47079073
50TCF4_22108803_ChIP-Seq_LS180_Human1.46602626
51NANOG_18555785_Chip-Seq_ESCs_Mouse1.45860309
52CDX2_22108803_ChIP-Seq_LS180_Human1.45716894
53MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.45227691
54* TCF4_23295773_ChIP-Seq_U87_Human1.44814470
55* RARB_27405468_Chip-Seq_BRAIN_Mouse1.43143165
56EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.42615901
57CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.41890458
58BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.41738559
59SOX2_19829295_ChIP-Seq_ESCs_Human1.40431986
60NANOG_19829295_ChIP-Seq_ESCs_Human1.40431986
61TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39130205
62ZNF217_24962896_ChIP-Seq_MCF-7_Human1.39094005
63JARID2_20075857_ChIP-Seq_MESCs_Mouse1.38494160
64RNF2_18974828_ChIP-Seq_MESCs_Mouse1.38307767
65EZH2_18974828_ChIP-Seq_MESCs_Mouse1.38307767
66TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.38217384
67* NFE2_27457419_Chip-Seq_LIVER_Mouse1.38123663
68SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.37831161
69TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.35008123
70ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.33822052
71* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.33436759
72SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.32159397
73FOXM1_26456572_ChIP-Seq_MCF-7_Human1.31660444
74BMI1_23680149_ChIP-Seq_NPCS_Mouse1.31518483
75HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.30366950
76CDX2_19796622_ChIP-Seq_MESCs_Mouse1.30274240
77ESR1_20079471_ChIP-ChIP_T-47D_Human1.29869324
78SALL1_21062744_ChIP-ChIP_HESCs_Human1.29639134
79* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.29076562
80* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.29045758
81OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28975105
82ESR2_21235772_ChIP-Seq_MCF-7_Human1.28855683
83TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27604559
84* P53_22387025_ChIP-Seq_ESCs_Mouse1.27539971
85GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.22517833
86AR_21572438_ChIP-Seq_LNCaP_Human1.21885381
87RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.21799272
88RUNX2_22187159_ChIP-Seq_PCA_Human1.21189665
89* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.21076009
90* CRX_20693478_ChIP-Seq_RETINA_Mouse1.20518277
91E2F1_18555785_Chip-Seq_ESCs_Mouse1.20460100
92TP53_22573176_ChIP-Seq_HFKS_Human1.19869417
93FOXA1_25329375_ChIP-Seq_VCAP_Human1.19256128
94FOXA1_27270436_Chip-Seq_PROSTATE_Human1.19256128
95* EZH2_27294783_Chip-Seq_ESCs_Mouse1.18879089
96GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.18854755
97PIAS1_25552417_ChIP-Seq_VCAP_Human1.16872640
98JARID2_20064375_ChIP-Seq_MESCs_Mouse1.16482011
99* NOTCH1_21737748_ChIP-Seq_TLL_Human1.15774858
100MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15205470
101* STAT3_18555785_Chip-Seq_ESCs_Mouse1.14491931
102SMAD4_21741376_ChIP-Seq_EPCs_Human1.14294082
103FLI1_21867929_ChIP-Seq_TH2_Mouse1.14279760
104KLF5_20875108_ChIP-Seq_MESCs_Mouse1.14107926
105EED_16625203_ChIP-ChIP_MESCs_Mouse1.13276464
106* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.12245979
107* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.11503956
108FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10730818
109EP300_21415370_ChIP-Seq_HL-1_Mouse1.10642338
110P300_18555785_Chip-Seq_ESCs_Mouse1.09373068
111REST_21632747_ChIP-Seq_MESCs_Mouse1.09329196
112* SOX2_18555785_Chip-Seq_ESCs_Mouse1.08316543
113CBX2_27304074_Chip-Seq_ESCs_Mouse1.07190082
114RNF2_27304074_Chip-Seq_NSC_Mouse1.06947933
115NCOR_22424771_ChIP-Seq_293T_Human1.05295824
116* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.05146804
117ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.04973757
118* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.04898201
119PRDM14_20953172_ChIP-Seq_ESCs_Human1.04855833
120TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04662075
121* CMYC_18555785_Chip-Seq_ESCs_Mouse1.04541204
122TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04180362
123HOXB7_26014856_ChIP-Seq_BT474_Human1.03428819
124* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03097978
125* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.02846799
126SMAD4_21799915_ChIP-Seq_A2780_Human1.02785537
127TBL1_22424771_ChIP-Seq_293T_Human1.01820191
128BCAT_22108803_ChIP-Seq_LS180_Human1.00727074
129* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.00627321
130* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00547793
131KDM2B_26808549_Chip-Seq_K562_Human1.00242673
132NR3C1_23031785_ChIP-Seq_PC12_Mouse1.00157827
133PHF8_20622853_ChIP-Seq_HELA_Human0.99759125
134AHR_22903824_ChIP-Seq_MCF-7_Human0.99423134
135ERG_21242973_ChIP-ChIP_JURKAT_Human0.97340156
136SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.97058237
137ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96961033
138RNF2_27304074_Chip-Seq_ESCs_Mouse0.96472840
139* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.94901991
140NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.93996521
141NRF2_20460467_ChIP-Seq_MEFs_Mouse0.93996521
142CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.93713992
143SOX2_21211035_ChIP-Seq_LN229_Gbm0.92615772
144PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.92377166
145ARNT_22903824_ChIP-Seq_MCF-7_Human0.92097258
146SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91417077
147* TBX20_22080862_ChIP-Seq_HEART_Mouse0.90961688
148* TBX20_22328084_ChIP-Seq_HEART_Mouse0.90961688
149ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.90446157
150TRIM28_21343339_ChIP-Seq_HEK293_Human0.89434865
151RARG_19884340_ChIP-ChIP_MEFs_Mouse0.88801090
152ESR1_21235772_ChIP-Seq_MCF-7_Human0.88129623
153* AR_19668381_ChIP-Seq_PC3_Human0.87554907
154EZH2_27304074_Chip-Seq_ESCs_Mouse0.87159711
155CDX2_20551321_ChIP-Seq_CACO-2_Human0.87099253
156RXR_22108803_ChIP-Seq_LS180_Human0.86827842
157DNAJC2_21179169_ChIP-ChIP_NT2_Human0.86625577
158ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.86524255
159* SMAD4_21741376_ChIP-Seq_HESCs_Human0.85677023
160STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.85656085
161* HNF4A_19822575_ChIP-Seq_HepG2_Human0.85636272
162* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.85075422
163GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84925922
164REST_18959480_ChIP-ChIP_MESCs_Mouse0.84754011
165AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.84672993
166GATA1_19941826_ChIP-Seq_K562_Human0.83791791
167* LXR_22292898_ChIP-Seq_THP-1_Human0.83670817
168CTNNB1_20460455_ChIP-Seq_HCT116_Human0.83071327
169* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.82122899
170* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.81493273
171SMAD3_21741376_ChIP-Seq_HESCs_Human0.81461563
172AR_25329375_ChIP-Seq_VCAP_Human0.81298901
173GATA2_21666600_ChIP-Seq_HMVEC_Human0.81244096
174IKZF1_21737484_ChIP-ChIP_HCT116_Human0.80401997
175SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.79849312
176WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.78513382
177STAT3_23295773_ChIP-Seq_U87_Human0.76999040
178CTCF_27219007_Chip-Seq_Bcells_Human0.76702725
179TP53_16413492_ChIP-PET_HCT116_Human0.74978852
180FOXO3_23340844_ChIP-Seq_DLD1_Human0.70914385

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.86896063
2MP0005360_urolithiasis5.18410982
3MP0005365_abnormal_bile_salt4.65310309
4MP0005085_abnormal_gallbladder_physiolo4.48729720
5MP0008875_abnormal_xenobiotic_pharmacok4.14931492
6MP0003252_abnormal_bile_duct3.04910784
7MP0010329_abnormal_lipoprotein_level3.02890760
8MP0005379_endocrine/exocrine_gland_phen2.70331337
9MP0002837_dystrophic_cardiac_calcinosis2.60060662
10MP0008877_abnormal_DNA_methylation2.57798298
11MP0005645_abnormal_hypothalamus_physiol2.48470298
12MP0004859_abnormal_synaptic_plasticity2.21993837
13MP0006072_abnormal_retinal_apoptosis2.21961158
14MP0002822_catalepsy2.21471539
15MP0009780_abnormal_chondrocyte_physiolo2.20618901
16MP0001666_abnormal_nutrient_absorption2.18399990
17MP0005083_abnormal_biliary_tract2.15599504
18MP0005551_abnormal_eye_electrophysiolog2.12052542
19MP0005332_abnormal_amino_acid2.11181308
20MP0002163_abnormal_gland_morphology2.02814946
21MP0003787_abnormal_imprinting2.01772897
22MP0009046_muscle_twitch2.01038318
23MP0004130_abnormal_muscle_cell1.99525594
24MP0005670_abnormal_white_adipose1.99410164
25MP0009840_abnormal_foam_cell1.98332458
26MP0002118_abnormal_lipid_homeostasis1.97929376
27MP0002909_abnormal_adrenal_gland1.93615923
28MP0000631_abnormal_neuroendocrine_gland1.92472001
29MP0003191_abnormal_cellular_cholesterol1.91950066
30MP0003195_calcinosis1.87697732
31MP0002638_abnormal_pupillary_reflex1.81812068
32MP0005253_abnormal_eye_physiology1.65751956
33MP0000427_abnormal_hair_cycle1.64456811
34MP0003806_abnormal_nucleotide_metabolis1.59767598
35MP0001485_abnormal_pinna_reflex1.56767960
36MP0000609_abnormal_liver_physiology1.56364885
37MP0003868_abnormal_feces_composition1.46402499
38MP0003329_amyloid_beta_deposits1.44570990
39MP0002138_abnormal_hepatobiliary_system1.41119730
40MP0005319_abnormal_enzyme/_coenzyme1.40377257
41MP0004043_abnormal_pH_regulation1.40269019
42* MP0005535_abnormal_body_temperature1.39904523
43MP0004019_abnormal_vitamin_homeostasis1.38840197
44MP0003635_abnormal_synaptic_transmissio1.38610071
45MP0010678_abnormal_skin_adnexa1.37368135
46* MP0008961_abnormal_basal_metabolism1.36507718
47MP0005389_reproductive_system_phenotype1.35636395
48MP0002102_abnormal_ear_morphology1.34616689
49MP0003718_maternal_effect1.34096736
50MP0002078_abnormal_glucose_homeostasis1.32768424
51MP0010386_abnormal_urinary_bladder1.32565455
52MP0000383_abnormal_hair_follicle1.30963550
53MP0005584_abnormal_enzyme/coenzyme_acti1.29699158
54MP0002160_abnormal_reproductive_system1.29494489
55MP0000751_myopathy1.28960223
56MP0001968_abnormal_touch/_nociception1.28908782
57MP0005666_abnormal_adipose_tissue1.28846418
58MP0000372_irregular_coat_pigmentation1.28377398
59MP0002277_abnormal_respiratory_mucosa1.24958764
60MP0002166_altered_tumor_susceptibility1.18240686
61* MP0009745_abnormal_behavioral_response1.17805029
62MP0002971_abnormal_brown_adipose1.17674501
63MP0005646_abnormal_pituitary_gland1.17590342
64MP0004133_heterotaxia1.16324810
65MP0002938_white_spotting1.16284675
66MP0000013_abnormal_adipose_tissue1.15752673
67MP0003646_muscle_fatigue1.14612048
68MP0002254_reproductive_system_inflammat1.14584929
69MP0002876_abnormal_thyroid_physiology1.13192301
70MP0004036_abnormal_muscle_relaxation1.12788023
71MP0004215_abnormal_myocardial_fiber1.12685289
72MP0009643_abnormal_urine_homeostasis1.10020630
73MP0005174_abnormal_tail_pigmentation1.08536899
74MP0003075_altered_response_to1.08062878
75MP0000604_amyloidosis1.08048262
76MP0004924_abnormal_behavior1.06663915
77MP0005386_behavior/neurological_phenoty1.06663915
78* MP0002063_abnormal_learning/memory/cond1.05480275
79MP0010368_abnormal_lymphatic_system1.04605806
80MP0002282_abnormal_trachea_morphology1.04335013
81MP0000569_abnormal_digit_pigmentation1.03307159
82MP0001765_abnormal_ion_homeostasis1.01390359
83MP0003690_abnormal_glial_cell1.00871131
84MP0001986_abnormal_taste_sensitivity1.00324344
85MP0001919_abnormal_reproductive_system0.98513074
86MP0005334_abnormal_fat_pad0.98276004
87MP0005448_abnormal_energy_balance0.97749347
88MP0010234_abnormal_vibrissa_follicle0.96281117
89* MP0001501_abnormal_sleep_pattern0.96232209
90MP0000639_abnormal_adrenal_gland0.95346532
91MP0003705_abnormal_hypodermis_morpholog0.95298573
92MP0005375_adipose_tissue_phenotype0.95036777
93* MP0001502_abnormal_circadian_rhythm0.94474077
94MP0004142_abnormal_muscle_tone0.93825134
95MP0004145_abnormal_muscle_electrophysio0.93792391
96MP0005075_abnormal_melanosome_morpholog0.93286329
97MP0001984_abnormal_olfaction0.92436055
98MP0003633_abnormal_nervous_system0.92231841
99* MP0002557_abnormal_social/conspecific_i0.91184793
100MP0005410_abnormal_fertilization0.90723163
101MP0003953_abnormal_hormone_level0.90500958
102MP0005395_other_phenotype0.90275421
103MP0003879_abnormal_hair_cell0.90182418
104MP0004270_analgesia0.88898388
105MP0000230_abnormal_systemic_arterial0.88561951
106MP0008058_abnormal_DNA_repair0.87433497
107MP0002090_abnormal_vision0.86948738
108MP0002064_seizures0.86939211
109MP0002009_preneoplasia0.86513156
110MP0002229_neurodegeneration0.85674128
111MP0005636_abnormal_mineral_homeostasis0.85362075
112MP0001764_abnormal_homeostasis0.84214220
113MP0001944_abnormal_pancreas_morphology0.83098977
114MP0002572_abnormal_emotion/affect_behav0.82766177
115MP0002168_other_aberrant_phenotype0.81257032
116MP0003011_delayed_dark_adaptation0.80508201
117MP0005330_cardiomyopathy0.80182728
118MP0001486_abnormal_startle_reflex0.79620196
119MP0000516_abnormal_urinary_system0.79304835
120MP0005367_renal/urinary_system_phenotyp0.79304835
121MP0003880_abnormal_central_pattern0.78796399
122MP0008872_abnormal_physiological_respon0.78431260
123MP0001970_abnormal_pain_threshold0.78405639
124MP0000015_abnormal_ear_pigmentation0.78126040
125MP0004085_abnormal_heartbeat0.78108480
126MP0008874_decreased_physiological_sensi0.77207348
127MP0003943_abnormal_hepatobiliary_system0.77131547
128MP0006276_abnormal_autonomic_nervous0.76810240
129MP0001756_abnormal_urination0.76708788
130MP0004084_abnormal_cardiac_muscle0.76708499
131MP0005220_abnormal_exocrine_pancreas0.76664822
132MP0002928_abnormal_bile_duct0.76546807
133MP0000749_muscle_degeneration0.75591883
134MP0004134_abnormal_chest_morphology0.75540915
135MP0003300_gastrointestinal_ulcer0.74782521
136MP0005310_abnormal_salivary_gland0.74365008
137MP0005084_abnormal_gallbladder_morpholo0.74310943
138MP0005620_abnormal_muscle_contractility0.74145827
139MP0004087_abnormal_muscle_fiber0.73536885
140MP0009642_abnormal_blood_homeostasis0.73255311
141MP0004185_abnormal_adipocyte_glucose0.73038908
142MP0002735_abnormal_chemical_nociception0.72189702
143MP0001440_abnormal_grooming_behavior0.71264290
144MP0005167_abnormal_blood-brain_barrier0.70268433
145MP0006138_congestive_heart_failure0.70230803
146MP0002269_muscular_atrophy0.69770059
147MP0002272_abnormal_nervous_system0.68748975
148MP0004858_abnormal_nervous_system0.68096703
149MP0003656_abnormal_erythrocyte_physiolo0.67638998
150MP0004885_abnormal_endolymph0.66289901
151MP0000003_abnormal_adipose_tissue0.65680518
152MP0005647_abnormal_sex_gland0.64423277
153MP0002693_abnormal_pancreas_physiology0.62733295
154MP0005166_decreased_susceptibility_to0.62640854
155MP0006036_abnormal_mitochondrial_physio0.60569550

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)4.94274637
2Abnormality of aromatic amino acid family metabolism (HP:0004338)4.67073110
3Intrahepatic cholestasis (HP:0001406)4.66390878
4Xanthomatosis (HP:0000991)4.51352581
5Hypoglycemic coma (HP:0001325)4.23902897
6Ketosis (HP:0001946)4.20346265
7Abnormality of monocarboxylic acid metabolism (HP:0010996)4.14942659
8Ketoacidosis (HP:0001993)3.94421657
9Hyperlipoproteinemia (HP:0010980)3.92217760
10Prolonged partial thromboplastin time (HP:0003645)3.88201151
11Pancreatic cysts (HP:0001737)3.87145932
12Pancreatic fibrosis (HP:0100732)3.80344063
13True hermaphroditism (HP:0010459)3.74617597
14Hypoalphalipoproteinemia (HP:0003233)3.60330420
15Complement deficiency (HP:0004431)3.44734449
16Hypobetalipoproteinemia (HP:0003563)3.43052914
17Hypothermia (HP:0002045)3.31092258
18Hypolipoproteinemia (HP:0010981)3.28608280
19Hyperammonemia (HP:0001987)3.27183938
20Epidermoid cyst (HP:0200040)3.26476271
21Nephronophthisis (HP:0000090)3.24334013
22Hyperglycinuria (HP:0003108)3.19932364
23Hypoglycemic seizures (HP:0002173)3.17661775
24Abnormality of the common coagulation pathway (HP:0010990)3.07725353
25Large for gestational age (HP:0001520)3.07425984
26Hyperinsulinemic hypoglycemia (HP:0000825)3.06189801
27Pendular nystagmus (HP:0012043)3.04502567
28Gout (HP:0001997)3.04325392
29Abnormality of glutamine family amino acid metabolism (HP:0010902)3.03171872
30Gaze-evoked nystagmus (HP:0000640)2.99721286
31Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.99073483
32Abnormality of the renal cortex (HP:0011035)2.98799897
33Intestinal atresia (HP:0011100)2.98301362
34Molar tooth sign on MRI (HP:0002419)2.96007500
35Abnormality of midbrain morphology (HP:0002418)2.96007500
36Cystic liver disease (HP:0006706)2.91923562
37Abnormality of serine family amino acid metabolism (HP:0010894)2.90383002
38Abnormality of glycine metabolism (HP:0010895)2.90383002
39Abnormality of the renal medulla (HP:0100957)2.89147924
40Hyperglycinemia (HP:0002154)2.86287199
41Methylmalonic acidemia (HP:0002912)2.80377068
42Skin nodule (HP:0200036)2.79588574
43Progressive cerebellar ataxia (HP:0002073)2.77984333
44Abnormality of sulfur amino acid metabolism (HP:0004339)2.77199166
45Hemiparesis (HP:0001269)2.77138677
46Hyperglycemia (HP:0003074)2.76856289
47Abnormality of vitamin B metabolism (HP:0004340)2.74975585
48Congenital stationary night blindness (HP:0007642)2.74691278
49Abnormality of purine metabolism (HP:0004352)2.71394112
50Abnormality of the intrinsic pathway (HP:0010989)2.66138952
51Joint hemorrhage (HP:0005261)2.62337755
52Abnormality of aspartate family amino acid metabolism (HP:0010899)2.62261858
53Abnormal rod and cone electroretinograms (HP:0008323)2.58380516
54Attenuation of retinal blood vessels (HP:0007843)2.56926560
55Fat malabsorption (HP:0002630)2.56410833
56Hypercholesterolemia (HP:0003124)2.56380594
57Late onset (HP:0003584)2.55045547
58Tubular atrophy (HP:0000092)2.52554580
59Furrowed tongue (HP:0000221)2.49635015
60Abnormality of methionine metabolism (HP:0010901)2.45136499
61Medial flaring of the eyebrow (HP:0010747)2.44196609
62Delayed CNS myelination (HP:0002188)2.44042058
63Conjugated hyperbilirubinemia (HP:0002908)2.42449143
64Metabolic acidosis (HP:0001942)2.39635423
65Abolished electroretinogram (ERG) (HP:0000550)2.39405110
66Hamartoma of the eye (HP:0010568)2.39375605
67Exercise-induced myalgia (HP:0003738)2.36018528
68Aplasia/hypoplasia of the uterus (HP:0008684)2.35806122
69Myoglobinuria (HP:0002913)2.35079008
70Hyperkalemia (HP:0002153)2.33140683
71Aqueductal stenosis (HP:0002410)2.31649739
72Symptomatic seizures (HP:0011145)2.31229529
73Abnormality of complement system (HP:0005339)2.30893769
74Genetic anticipation (HP:0003743)2.27704969
75Abnormality of fatty-acid metabolism (HP:0004359)2.27540142
76Congenital sensorineural hearing impairment (HP:0008527)2.23933518
77Increased circulating renin level (HP:0000848)2.23195669
78Hyperbilirubinemia (HP:0002904)2.22977884
79Polydipsia (HP:0001959)2.22957248
80Abnormal drinking behavior (HP:0030082)2.22957248
81Decreased circulating renin level (HP:0003351)2.22087170
82Abnormality of the nasal septum (HP:0000419)2.21473746
83Hyperventilation (HP:0002883)2.20679224
84Methylmalonic aciduria (HP:0012120)2.20631151
85Focal motor seizures (HP:0011153)2.20014311
86Short hallux (HP:0010109)2.18553120
87Myocardial infarction (HP:0001658)2.17616790
88Type II lissencephaly (HP:0007260)2.16673696
89Status epilepticus (HP:0002133)2.13841910
90Renal cortical cysts (HP:0000803)2.13580517
91Abnormality of nucleobase metabolism (HP:0010932)2.12205867
92Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.11541961
93Abnormality of macular pigmentation (HP:0008002)2.11078315
94Abnormality of vitamin metabolism (HP:0100508)2.10860288
95Dysmetric saccades (HP:0000641)2.10650402
96Abnormal gallbladder morphology (HP:0012437)2.08410290
97Agitation (HP:0000713)2.07857709
98Sensorimotor neuropathy (HP:0007141)2.07241915
99Labial hypoplasia (HP:0000066)2.06417293
100Aplasia/Hypoplasia of the hallux (HP:0008362)2.06287535
101Neonatal onset (HP:0003623)2.06216126
102Decreased central vision (HP:0007663)2.06143030
103Hypoplastic labia majora (HP:0000059)2.04241300
104Abnormality of dicarboxylic acid metabolism (HP:0010995)2.04051831
105Dicarboxylic aciduria (HP:0003215)2.04051831
106Hyperactive renin-angiotensin system (HP:0000841)2.02599912
107Increased purine levels (HP:0004368)2.02352447
108Hyperuricemia (HP:0002149)2.02352447
109Severe visual impairment (HP:0001141)2.00702622
110Cholelithiasis (HP:0001081)2.00307173
111Male pseudohermaphroditism (HP:0000037)1.98693759
112Dynein arm defect of respiratory motile cilia (HP:0012255)1.97473894
113Absent/shortened dynein arms (HP:0200106)1.97473894
114Increased corneal curvature (HP:0100692)1.97036621
115Keratoconus (HP:0000563)1.97036621
116Oligodactyly (hands) (HP:0001180)1.94104460
117Broad-based gait (HP:0002136)1.93997142
118Sudden death (HP:0001699)1.93322844
119Fair hair (HP:0002286)1.93304888
120Atrioventricular block (HP:0001678)1.92345791
121Broad metatarsal (HP:0001783)1.92108420
122Thyroiditis (HP:0100646)1.91620608
123Mitral stenosis (HP:0001718)1.91504603
124Congenital, generalized hypertrichosis (HP:0004540)1.89866393
125Generalized aminoaciduria (HP:0002909)1.89254827
126Abnormality of serum amino acid levels (HP:0003112)1.89022682
127Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.88990857
128Aplasia/Hypoplasia of the tongue (HP:0010295)1.88693111
129Chronic hepatic failure (HP:0100626)1.88537761
130Congenital hepatic fibrosis (HP:0002612)1.88430617
131Long toe (HP:0010511)1.88196899
132Polyuria (HP:0000103)1.87958768
133Syncope (HP:0001279)1.87605171
134Hydroxyprolinuria (HP:0003080)1.87374955
135Abnormality of proline metabolism (HP:0010907)1.87374955
136Adrenal hypoplasia (HP:0000835)1.86916172
137Widely spaced teeth (HP:0000687)1.86593558
138Progressive macrocephaly (HP:0004481)1.85778585
139Abnormal respiratory epithelium morphology (HP:0012253)1.85361994
140Abnormal respiratory motile cilium morphology (HP:0005938)1.85361994
141Impaired social interactions (HP:0000735)1.84007107
142Abnormal social behavior (HP:0012433)1.84007107
143Turricephaly (HP:0000262)1.83669796
144Absent speech (HP:0001344)1.83199857
145Abnormality of the labia majora (HP:0012881)1.83111163
146Visual hallucinations (HP:0002367)1.82853807
147Confusion (HP:0001289)1.82397564
148Hypoplasia of the uterus (HP:0000013)1.82067008
149Abnormal ciliary motility (HP:0012262)1.81772980
150Abnormality of renin-angiotensin system (HP:0000847)1.81225496
151Abnormality of the parathyroid morphology (HP:0011766)1.80999570
152Enlarged kidneys (HP:0000105)1.80862663
153EEG with generalized epileptiform discharges (HP:0011198)1.80445920
154Right ventricular cardiomyopathy (HP:0011663)1.79806782
155Abnormality of the pancreatic islet cells (HP:0006476)1.79570772
156Abnormality of endocrine pancreas physiology (HP:0012093)1.79570772
157Insulin-resistant diabetes mellitus (HP:0000831)1.79452604
158Bony spicule pigmentary retinopathy (HP:0007737)1.79139128
159Febrile seizures (HP:0002373)1.78942641
160Esophageal varix (HP:0002040)1.78407158
161Epileptiform EEG discharges (HP:0011182)1.78264967
162Prolonged QT interval (HP:0001657)1.78187262
163Pancreatic islet-cell hyperplasia (HP:0004510)1.77673352
164Hypsarrhythmia (HP:0002521)1.77581164
165Rhinitis (HP:0012384)1.77056230
166Abnormal biliary tract physiology (HP:0012439)1.77019125
167Bile duct proliferation (HP:0001408)1.77019125
168Abnormality of the labia minora (HP:0012880)1.76831487
169Hypoplastic female external genitalia (HP:0012815)1.76728785
170Severe muscular hypotonia (HP:0006829)1.76474168
171Heart block (HP:0012722)1.75325360
172Hypomagnesemia (HP:0002917)1.74955159
173Sclerocornea (HP:0000647)1.74887749
174Occipital encephalocele (HP:0002085)1.74340927
175Hypoplasia of the fovea (HP:0007750)1.73577954
176Aplasia/Hypoplasia of the fovea (HP:0008060)1.73577954
177Albinism (HP:0001022)1.72773804
178Acanthocytosis (HP:0001927)1.72177429
179Torticollis (HP:0000473)1.72161292
180Abnormality of the vitamin B12 metabolism (HP:0004341)1.70603253
181Insulin resistance (HP:0000855)1.70185785
182Double outlet right ventricle (HP:0001719)1.70114210
183Congenital malformation of the right heart (HP:0011723)1.70114210
184Toxemia of pregnancy (HP:0100603)1.69828130
185Bundle branch block (HP:0011710)1.69700103
186Acute hepatic failure (HP:0006554)1.68243507
187Abnormal atrioventricular conduction (HP:0005150)1.67147001
188Action tremor (HP:0002345)1.66604096
189Polycythemia (HP:0001901)1.66118440
190Focal seizures (HP:0007359)1.65700047
191Lymphangioma (HP:0100764)1.64936545

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST44.87118478
2CASK3.51575990
3INSRR3.07344163
4EPHA43.03677491
5NUAK12.86051718
6GRK12.72307959
7TRIB32.71316765
8SIK12.66578659
9BRSK22.63760009
10RIPK12.61159854
11STK242.60797982
12BCKDK2.57460354
13DAPK22.48877182
14NTRK32.37196997
15ERN12.24353568
16MAP4K22.14031045
17ADRBK22.10975503
18EIF2AK31.99113286
19FRK1.94491923
20MUSK1.94128855
21MKNK21.88914432
22WNK31.78487536
23STK391.75356636
24STK38L1.68856082
25OXSR11.64355714
26MAP3K21.62094405
27MAP2K41.55992068
28FGFR41.51205875
29PINK11.48479128
30PRKD31.40687596
31TLK11.40631677
32ERBB31.39719493
33WNK41.38560573
34LATS11.32737438
35MAP3K71.32691210
36SGK31.32592958
37PKN21.30251498
38TAOK31.29645474
39MAPK131.28535271
40TAOK21.26361224
41TAOK11.26107589
42BMPR1B1.25447677
43TRIM281.24503983
44CAMK1D1.23568240
45FGFR21.20975563
46SGK21.20396948
47CAMK1G1.17377233
48TNIK1.17172648
49WEE11.16311399
50CAMKK11.13805398
51PHKG11.13669898
52PHKG21.13669898
53LMTK21.11951121
54DMPK1.11384229
55MAP3K41.10686055
56TTN1.10354834
57PRKAA21.10187299
58CSNK1G11.08919266
59PRKCI1.08705422
60PRKCE1.04712208
61PTK61.03933121
62STK381.03698346
63NTRK11.03074817
64ZAK1.03032686
65PLK20.98693419
66MAP3K30.98252046
67PAK30.95053847
68EIF2AK10.94879196
69MST1R0.94847054
70MAP3K10.91495013
71CSNK1G30.90995046
72FLT30.89790282
73PRKCH0.89373556
74CSNK1G20.87232672
75FGFR30.86972936
76MYLK0.86468485
77MAPK150.86128452
78SGK2230.85858458
79SGK4940.85858458
80KSR20.84233154
81NLK0.83400134
82MAPKAPK30.82642064
83TNK20.81479757
84ACVR1B0.80712967
85MAP3K90.79964899
86MARK20.79137539
87PTK2B0.77548008
88CAMK10.76616171
89CAMKK20.76474323
90TIE10.75991706
91RET0.75831379
92OBSCN0.75147418
93CSNK1A1L0.75063469
94NTRK20.72527019
95SIK20.72385024
96PRKAA10.72300694
97IKBKB0.71236276
98PIK3CA0.70656343
99PDPK10.69701789
100MAP2K30.69118964
101TRPM70.68903674
102TEC0.68383145
103MAPK120.68212582
104PRKCQ0.67866755
105STK30.67718355
106SGK10.66842986
107JAK20.66745052
108PTK20.66661274
109JAK10.66339946
110STK110.66302815
111CAMK40.65963866
112RIPK40.65088574
113DAPK10.64121848
114PDGFRA0.62171638
115EPHA30.61870035
116AKT30.60797530
117PRKCZ0.60155327
118PRKACG0.59610609
119CAMK2G0.59328802
120MINK10.59279854
121MAPK70.59141238
122ADRBK10.58700095
123CDK50.58390903
124MAP2K60.58244887
125EPHB10.58134098
126STK100.57962421
127HIPK20.57468474
128PDK10.55026600
129FES0.54827321
130FER0.54600367
131MAP2K10.54464231
132CHUK0.53726423
133CDC42BPA0.53594422
134PRKD10.51805386
135PRKCG0.51282373
136PRKD20.50658325
137BCR0.49692618
138CAMK2A0.48868913
139BRSK10.48170724
140PAK60.48120665
141MAPK110.48035324
142RPS6KA30.47899811
143PIK3CG0.47887227
144MKNK10.46491781
145ERBB20.45913775
146CAMK2D0.45786943
147SIK30.43053119
148PRKACA0.39956581
149PNCK0.38684333
150CSNK1A10.36440571
151GRK50.35644118
152PLK30.35493104
153EIF2AK20.33932975
154PRKG10.33789971
155VRK10.33569077
156ROCK10.33553059
157ABL10.32739831
158EPHA20.32201306
159IRAK10.31963109
160PRKCA0.28554646
161GRK70.27521091

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.63896964
2Protein export_Homo sapiens_hsa030603.29265356
3Primary bile acid biosynthesis_Homo sapiens_hsa001203.18828019
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.75675104
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.71709045
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.61543777
7Arginine biosynthesis_Homo sapiens_hsa002202.47173657
8Phototransduction_Homo sapiens_hsa047442.41146948
9Fatty acid degradation_Homo sapiens_hsa000712.39663367
10Tryptophan metabolism_Homo sapiens_hsa003802.10202721
11Linoleic acid metabolism_Homo sapiens_hsa005912.02972911
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.99836576
13Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.95628809
14PPAR signaling pathway_Homo sapiens_hsa033201.89951905
15Butanoate metabolism_Homo sapiens_hsa006501.87430852
16Bile secretion_Homo sapiens_hsa049761.83149985
17Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.80659104
18Propanoate metabolism_Homo sapiens_hsa006401.78616667
19Fatty acid metabolism_Homo sapiens_hsa012121.77808008
20Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.77331713
21Ether lipid metabolism_Homo sapiens_hsa005651.71768705
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.71219845
23Complement and coagulation cascades_Homo sapiens_hsa046101.70804191
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.68506455
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.67441976
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.64340053
27Pentose and glucuronate interconversions_Homo sapiens_hsa000401.59274809
28Vitamin B6 metabolism_Homo sapiens_hsa007501.52850986
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.48018216
30Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.46068513
31Oxidative phosphorylation_Homo sapiens_hsa001901.42448674
32Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.41887322
33Starch and sucrose metabolism_Homo sapiens_hsa005001.41171992
34Sphingolipid metabolism_Homo sapiens_hsa006001.38258017
35Peroxisome_Homo sapiens_hsa041461.37937605
36beta-Alanine metabolism_Homo sapiens_hsa004101.36691104
37Collecting duct acid secretion_Homo sapiens_hsa049661.31665179
38Steroid hormone biosynthesis_Homo sapiens_hsa001401.31073001
39Basal transcription factors_Homo sapiens_hsa030221.28358519
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.26767819
41Caffeine metabolism_Homo sapiens_hsa002321.25551814
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.25277757
43Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.23718290
44RNA degradation_Homo sapiens_hsa030181.22787731
45ABC transporters_Homo sapiens_hsa020101.20798023
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.20117239
47Histidine metabolism_Homo sapiens_hsa003401.17471564
48Chemical carcinogenesis_Homo sapiens_hsa052041.16074315
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.15530289
50Dorso-ventral axis formation_Homo sapiens_hsa043201.15059960
51Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.13810169
52Fat digestion and absorption_Homo sapiens_hsa049751.12646932
53Fatty acid biosynthesis_Homo sapiens_hsa000611.11807285
54Insulin secretion_Homo sapiens_hsa049111.10423231
55Regulation of autophagy_Homo sapiens_hsa041401.09756482
56Lysine degradation_Homo sapiens_hsa003101.09349700
57Aldosterone synthesis and secretion_Homo sapiens_hsa049251.07721799
58Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.06954091
59Homologous recombination_Homo sapiens_hsa034401.05687380
60Phenylalanine metabolism_Homo sapiens_hsa003601.03593682
61SNARE interactions in vesicular transport_Homo sapiens_hsa041301.02426153
62Pyruvate metabolism_Homo sapiens_hsa006201.02141735
63Mineral absorption_Homo sapiens_hsa049781.01452133
64Sulfur metabolism_Homo sapiens_hsa009200.95888044
65* Circadian entrainment_Homo sapiens_hsa047130.94210246
66Type I diabetes mellitus_Homo sapiens_hsa049400.93039461
67RNA polymerase_Homo sapiens_hsa030200.92953398
68Type II diabetes mellitus_Homo sapiens_hsa049300.92072277
69GABAergic synapse_Homo sapiens_hsa047270.91861069
70Fanconi anemia pathway_Homo sapiens_hsa034600.91228217
71Retinol metabolism_Homo sapiens_hsa008300.88720520
72Glycerolipid metabolism_Homo sapiens_hsa005610.87472782
73Insulin resistance_Homo sapiens_hsa049310.84544914
74Carbon metabolism_Homo sapiens_hsa012000.83158675
75Nicotine addiction_Homo sapiens_hsa050330.82105811
76Tyrosine metabolism_Homo sapiens_hsa003500.81453186
77Glucagon signaling pathway_Homo sapiens_hsa049220.80980546
78Staphylococcus aureus infection_Homo sapiens_hsa051500.80701272
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.78924554
80Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.78652093
81Serotonergic synapse_Homo sapiens_hsa047260.78347391
82Selenocompound metabolism_Homo sapiens_hsa004500.77093292
83Salivary secretion_Homo sapiens_hsa049700.76126126
84Glutamatergic synapse_Homo sapiens_hsa047240.75665655
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.75220912
86Olfactory transduction_Homo sapiens_hsa047400.75155922
87Amphetamine addiction_Homo sapiens_hsa050310.74367132
88Arachidonic acid metabolism_Homo sapiens_hsa005900.73969955
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72970859
90Morphine addiction_Homo sapiens_hsa050320.72502137
91Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.72288829
92Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.71736698
93Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.69730550
94Renin secretion_Homo sapiens_hsa049240.69017299
95Proteasome_Homo sapiens_hsa030500.68366980
96Parkinsons disease_Homo sapiens_hsa050120.68161434
97Long-term potentiation_Homo sapiens_hsa047200.67762552
98Folate biosynthesis_Homo sapiens_hsa007900.67630890
99Ovarian steroidogenesis_Homo sapiens_hsa049130.67060986
100Gastric acid secretion_Homo sapiens_hsa049710.62348416
101* Circadian rhythm_Homo sapiens_hsa047100.61841134
102Cocaine addiction_Homo sapiens_hsa050300.61825242
103Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.61216193
104Biosynthesis of amino acids_Homo sapiens_hsa012300.60985610
105Arginine and proline metabolism_Homo sapiens_hsa003300.59602322
106One carbon pool by folate_Homo sapiens_hsa006700.59371950
107Vitamin digestion and absorption_Homo sapiens_hsa049770.57898724
108Non-homologous end-joining_Homo sapiens_hsa034500.57351683
109Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.55592897
110Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55557609
111Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.55555123
112Cysteine and methionine metabolism_Homo sapiens_hsa002700.54808204
113Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54328968
114Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54055110
115Metabolic pathways_Homo sapiens_hsa011000.54003401
116Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.53949018
117Thyroid hormone synthesis_Homo sapiens_hsa049180.53533793
118Calcium signaling pathway_Homo sapiens_hsa040200.51544312
119Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.51359879
120Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.51199719
121cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51100669
122cAMP signaling pathway_Homo sapiens_hsa040240.50974116
123Long-term depression_Homo sapiens_hsa047300.50593020
124Dilated cardiomyopathy_Homo sapiens_hsa054140.49709115
125Pancreatic secretion_Homo sapiens_hsa049720.49010070
126Insulin signaling pathway_Homo sapiens_hsa049100.48494361
127Purine metabolism_Homo sapiens_hsa002300.48044309
128Cholinergic synapse_Homo sapiens_hsa047250.47873400
129Alzheimers disease_Homo sapiens_hsa050100.47121184
130Huntingtons disease_Homo sapiens_hsa050160.47038210
131Taste transduction_Homo sapiens_hsa047420.46505839
132Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.44192556
133Oxytocin signaling pathway_Homo sapiens_hsa049210.43670581
134Synaptic vesicle cycle_Homo sapiens_hsa047210.43609202
135Glutathione metabolism_Homo sapiens_hsa004800.42912697
136Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42782657
137AMPK signaling pathway_Homo sapiens_hsa041520.41962689
138Dopaminergic synapse_Homo sapiens_hsa047280.41386861
139Intestinal immune network for IgA production_Homo sapiens_hsa046720.40409237
140Fatty acid elongation_Homo sapiens_hsa000620.40256506
141Cardiac muscle contraction_Homo sapiens_hsa042600.37708053
142Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36606735
143Vascular smooth muscle contraction_Homo sapiens_hsa042700.34989238
144GnRH signaling pathway_Homo sapiens_hsa049120.34134132
145Galactose metabolism_Homo sapiens_hsa000520.34024178

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