PEG3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: In human, ZIM2 and PEG3 are treated as two distinct genes though they share multiple 5' exons and a common promoter and both genes are paternally expressed (PMID:15203203). Alternative splicing events connect their shared 5' exons either with the remaining 4 exons unique to ZIM2, or with the remaining 2 exons unique to PEG3. In contrast, in other mammals ZIM2 does not undergo imprinting and, in mouse, cow, and likely other mammals as well, the ZIM2 and PEG3 genes do not share exons. Human PEG3 protein belongs to the Kruppel C2H2-type zinc finger protein family. PEG3 may play a role in cell proliferation and p53-mediated apoptosis. PEG3 has also shown tumor suppressor activity and tumorigenesis in glioma and ovarian cells. Alternative splicing of this PEG3 gene results in multiple transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neurotransmitter-gated ion channel clustering (GO:0072578)5.01193701
2very-low-density lipoprotein particle assembly (GO:0034379)4.88904898
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.84743427
4COPI coating of Golgi vesicle (GO:0048205)4.81216311
5Golgi transport vesicle coating (GO:0048200)4.81216311
6plasma lipoprotein particle assembly (GO:0034377)4.40184434
7cellular sodium ion homeostasis (GO:0006883)4.39544727
8positive regulation of dendritic spine morphogenesis (GO:0061003)4.36682688
9intestinal cholesterol absorption (GO:0030299)4.04125521
10response to follicle-stimulating hormone (GO:0032354)4.02475660
11low-density lipoprotein particle remodeling (GO:0034374)4.01613736
12positive regulation of synapse maturation (GO:0090129)3.97048409
13protein-lipid complex assembly (GO:0065005)3.96960396
14regulation of short-term neuronal synaptic plasticity (GO:0048172)3.93857036
15cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.91102602
16central nervous system myelination (GO:0022010)3.86947649
17axon ensheathment in central nervous system (GO:0032291)3.86947649
18cholesterol efflux (GO:0033344)3.83003925
19embryonic retina morphogenesis in camera-type eye (GO:0060059)3.80475063
20negative regulation of fibrinolysis (GO:0051918)3.78554873
21synaptic vesicle maturation (GO:0016188)3.70749194
22protein-lipid complex remodeling (GO:0034368)3.66058706
23macromolecular complex remodeling (GO:0034367)3.66058706
24plasma lipoprotein particle remodeling (GO:0034369)3.66058706
25response to pheromone (GO:0019236)3.54435198
26regulation of synaptic vesicle exocytosis (GO:2000300)3.53350483
27protein localization to synapse (GO:0035418)3.52223046
28positive regulation of male gonad development (GO:2000020)3.51523949
29high-density lipoprotein particle remodeling (GO:0034375)3.50977449
30C4-dicarboxylate transport (GO:0015740)3.42961507
31plasma lipoprotein particle organization (GO:0071827)3.42281365
32insulin secretion (GO:0030073)3.41774908
33regulation of apoptotic cell clearance (GO:2000425)3.40164116
34reverse cholesterol transport (GO:0043691)3.40132008
35regulation of protein activation cascade (GO:2000257)3.36882252
36protein carboxylation (GO:0018214)3.35791863
37peptidyl-glutamic acid carboxylation (GO:0017187)3.35791863
38regulation of complement activation (GO:0030449)3.33958948
39glucocorticoid metabolic process (GO:0008211)3.32919588
40locomotory exploration behavior (GO:0035641)3.32351638
41regulation of cholesterol esterification (GO:0010872)3.31980129
42regulation of fibrinolysis (GO:0051917)3.27477666
43protein-lipid complex subunit organization (GO:0071825)3.24638136
44cellular potassium ion homeostasis (GO:0030007)3.24628404
45cerebellar Purkinje cell layer development (GO:0021680)3.24252632
46synaptic vesicle exocytosis (GO:0016079)3.20323279
47innervation (GO:0060384)3.19543153
48cerebellar granule cell differentiation (GO:0021707)3.18089983
49regulation of cholesterol homeostasis (GO:2000188)3.16969375
50ionotropic glutamate receptor signaling pathway (GO:0035235)3.16648680
51retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.16373596
52regulation of dendritic spine morphogenesis (GO:0061001)3.16359851
53exocrine pancreas development (GO:0031017)3.14091205
54neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.13096131
55axonal fasciculation (GO:0007413)3.12982613
56body morphogenesis (GO:0010171)3.11835310
57regulation of synapse maturation (GO:0090128)3.11189285
58positive regulation of dendritic spine development (GO:0060999)3.11030601
59cerebellar Purkinje cell differentiation (GO:0021702)3.10767928
60regulation of synaptic vesicle transport (GO:1902803)3.09179476
61regulation of bile acid biosynthetic process (GO:0070857)3.07565125
62glucocorticoid biosynthetic process (GO:0006704)3.07231243
63plasma lipoprotein particle clearance (GO:0034381)3.06433410
64dendritic spine morphogenesis (GO:0060997)3.06199567
65detection of calcium ion (GO:0005513)3.05838367
66mating behavior (GO:0007617)3.05122200
67neurotransmitter secretion (GO:0007269)3.04038463
68positive regulation of hormone biosynthetic process (GO:0046886)3.03741509
69negative regulation of sodium ion transport (GO:0010766)3.02337800
70peptide hormone processing (GO:0016486)3.02157823
71lung epithelium development (GO:0060428)3.00663545
72growth hormone secretion (GO:0030252)2.99846646
73sodium ion export (GO:0071436)2.99289683
74neuromuscular process controlling posture (GO:0050884)2.98066398
75low-density lipoprotein particle clearance (GO:0034383)2.96287652
76presynaptic membrane assembly (GO:0097105)2.95106258
77estrogen biosynthetic process (GO:0006703)2.94211071
78postsynaptic membrane organization (GO:0001941)2.93225552
79activation of protein kinase A activity (GO:0034199)2.92694485
80neuron recognition (GO:0008038)2.92624087
81androgen biosynthetic process (GO:0006702)2.92436914
82nephron tubule morphogenesis (GO:0072078)2.92120363
83nephron epithelium morphogenesis (GO:0072088)2.92120363
84positive regulation of synaptic transmission, GABAergic (GO:0032230)2.90403494
85layer formation in cerebral cortex (GO:0021819)2.89782482
86chondrocyte development (GO:0002063)2.89565544
87regulation of cholesterol biosynthetic process (GO:0045540)2.87576898
88regulation of calcium ion-dependent exocytosis (GO:0017158)2.87557809
89maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.86149501
90negative regulation of astrocyte differentiation (GO:0048712)2.85418641
91neuron cell-cell adhesion (GO:0007158)2.84774596
92response to insecticide (GO:0017085)2.83932309
93cellular response to gonadotropin stimulus (GO:0071371)2.82280951
94L-amino acid import (GO:0043092)2.81803758
95type B pancreatic cell development (GO:0003323)2.79832814
96peptide hormone secretion (GO:0030072)2.79729749
97regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.79240365
98inner ear receptor cell development (GO:0060119)2.77999077
99C21-steroid hormone metabolic process (GO:0008207)2.77378650
100glutamate secretion (GO:0014047)2.76946449
101regulation of male gonad development (GO:2000018)2.76264456
102exploration behavior (GO:0035640)2.74408300
103establishment of nucleus localization (GO:0040023)2.74283393
104membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.73079132
105vesicle coating (GO:0006901)2.72937541
106presynaptic membrane organization (GO:0097090)2.72375189
107neuronal action potential propagation (GO:0019227)2.71996726
108negative regulation of dendrite morphogenesis (GO:0050774)2.71973759
109positive regulation of hormone metabolic process (GO:0032352)2.70713592
110blood coagulation, intrinsic pathway (GO:0007597)2.70600239
111artery smooth muscle contraction (GO:0014824)2.70021268
112endocrine pancreas development (GO:0031018)2.69842978
113peptide secretion (GO:0002790)2.69801891
114regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.69793833
115glandular epithelial cell development (GO:0002068)2.69434951
116regulation of insulin secretion (GO:0050796)2.68031173
117progesterone metabolic process (GO:0042448)2.67900378
118stress granule assembly (GO:0034063)2.66699572
119cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.66295072
120synaptic vesicle docking involved in exocytosis (GO:0016081)2.66215703
121glutamate receptor signaling pathway (GO:0007215)2.66112995
122vocalization behavior (GO:0071625)2.65894525
123proline transport (GO:0015824)2.65584455
124regulation of glucocorticoid secretion (GO:2000849)2.64640548
125protein maturation by protein folding (GO:0022417)2.64589853
126regulation of non-canonical Wnt signaling pathway (GO:2000050)2.64047999
127COPII vesicle coating (GO:0048208)2.63385234
128long-term memory (GO:0007616)2.61543793
129sodium ion homeostasis (GO:0055078)2.61376266
130regulation of dendritic spine development (GO:0060998)2.60407304
131positive regulation of steroid metabolic process (GO:0045940)2.60330722
132vesicle transport along microtubule (GO:0047496)2.59627288
133positive regulation of insulin secretion (GO:0032024)2.59203150
134dorsal/ventral axis specification (GO:0009950)2.58778489
135gamma-aminobutyric acid transport (GO:0015812)2.58484786
136suckling behavior (GO:0001967)2.58199430
137cell communication by electrical coupling (GO:0010644)2.56586333
138signal release (GO:0023061)2.54728002
139regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.53095422
140regulation of glutamate receptor signaling pathway (GO:1900449)2.52819953
141neurotransmitter transport (GO:0006836)2.50591905
142intra-Golgi vesicle-mediated transport (GO:0006891)2.48709282
143hindbrain development (GO:0030902)2.48564298
144regulation of neuronal synaptic plasticity (GO:0048168)2.47986406
145regulation of peptide hormone secretion (GO:0090276)2.46865628
146regulation of vesicle fusion (GO:0031338)2.46041289
147membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.45720064
148glandular epithelial cell differentiation (GO:0002067)2.45049549
149negative regulation of glycogen biosynthetic process (GO:0045719)2.44426050
150regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.43613295
151regulation of peptide secretion (GO:0002791)2.43562925
152cellular response to glucagon stimulus (GO:0071377)2.43375328
153pre-miRNA processing (GO:0031054)2.42676198
154somite development (GO:0061053)2.42516544
155positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.42412557
156chemosensory behavior (GO:0007635)2.42317074
157regulation of long-term neuronal synaptic plasticity (GO:0048169)2.41107263
158glycine transport (GO:0015816)2.40565284
159membrane repolarization during action potential (GO:0086011)2.40536999
160protein targeting to Golgi (GO:0000042)2.40142424
161dendrite morphogenesis (GO:0048813)2.39654492
162protein retention in ER lumen (GO:0006621)2.37913495
163cerebellum development (GO:0021549)2.37786532
164regulation of growth hormone secretion (GO:0060123)2.34297675
165organelle transport along microtubule (GO:0072384)2.34183991
166regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.33863725
167membrane depolarization during action potential (GO:0086010)2.33516900
168positive regulation of gastrulation (GO:2000543)2.32662305
169regulation of axon extension involved in axon guidance (GO:0048841)2.31926914
170regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.31040897
171regulation of glycogen (starch) synthase activity (GO:2000465)2.30625713
172positive regulation of vesicle fusion (GO:0031340)2.29475458
173renal tubule morphogenesis (GO:0061333)2.29471137
174transmission of nerve impulse (GO:0019226)2.28307587
175positive regulation of exocytosis (GO:0045921)2.27392662

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.27415982
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.16652611
3GBX2_23144817_ChIP-Seq_PC3_Human2.93890297
4CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.62878916
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.58091140
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.57488782
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.53556975
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.53518452
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.42456076
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.39004135
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.29876658
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.28011561
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.27626048
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.25087484
15FOXA2_19822575_ChIP-Seq_HepG2_Human2.25040006
16RNF2_18974828_ChIP-Seq_MESCs_Mouse2.24907045
17EZH2_18974828_ChIP-Seq_MESCs_Mouse2.24907045
18NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.19987762
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.14499749
20REST_21632747_ChIP-Seq_MESCs_Mouse2.14125927
21SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.12222288
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.00892836
23SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.00825888
24MTF2_20144788_ChIP-Seq_MESCs_Mouse2.00577293
25RNF2_27304074_Chip-Seq_ESCs_Mouse1.93152105
26* ZNF274_21170338_ChIP-Seq_K562_Hela1.92198439
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.91755018
28HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.91187364
29* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.87647581
30EZH2_27294783_Chip-Seq_ESCs_Mouse1.87573716
31DROSHA_22980978_ChIP-Seq_HELA_Human1.84523603
32IGF1R_20145208_ChIP-Seq_DFB_Human1.82366140
33SUZ12_27294783_Chip-Seq_ESCs_Mouse1.78745625
34REST_18959480_ChIP-ChIP_MESCs_Mouse1.74297874
35CBX2_27304074_Chip-Seq_ESCs_Mouse1.65743627
36RARB_27405468_Chip-Seq_BRAIN_Mouse1.64067950
37SMAD4_21799915_ChIP-Seq_A2780_Human1.64004823
38NR3C1_23031785_ChIP-Seq_PC12_Mouse1.63853908
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.61302283
40PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.56952916
41PIAS1_25552417_ChIP-Seq_VCAP_Human1.54909251
42NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.53158384
43PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.50944303
44THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.49547275
45MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.49283528
46CTNNB1_20460455_ChIP-Seq_HCT116_Human1.49188260
47RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.48998819
48RBPJ_22232070_ChIP-Seq_NCS_Mouse1.47090504
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.46495453
50SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.44258717
51STAT3_23295773_ChIP-Seq_U87_Human1.44114913
52RNF2_27304074_Chip-Seq_NSC_Mouse1.43697777
53TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.41804753
54P300_19829295_ChIP-Seq_ESCs_Human1.41222017
55LXR_22158963_ChIP-Seq_LIVER_Mouse1.40195035
56TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40059666
57* SOX2_21211035_ChIP-Seq_LN229_Gbm1.39509179
58SALL1_21062744_ChIP-ChIP_HESCs_Human1.36974388
59POU3F2_20337985_ChIP-ChIP_501MEL_Human1.36604978
60TCF4_18268006_ChIP-ChIP_LS174T_Human1.35070488
61YAP1_20516196_ChIP-Seq_MESCs_Mouse1.35012905
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34825041
63* AR_19668381_ChIP-Seq_PC3_Human1.34712654
64DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.32056691
65SMAD3_21741376_ChIP-Seq_EPCs_Human1.30733676
66CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.30652559
67DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.29446665
68TAF15_26573619_Chip-Seq_HEK293_Human1.29206522
69TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28682752
70OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28655752
71ZNF217_24962896_ChIP-Seq_MCF-7_Human1.28239541
72EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27134366
73* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.26891187
74CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.26690857
75ISL1_27105846_Chip-Seq_CPCs_Mouse1.25396607
76* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.23328229
77RING1B_27294783_Chip-Seq_ESCs_Mouse1.23149225
78AR_21572438_ChIP-Seq_LNCaP_Human1.22722284
79HNF4A_19822575_ChIP-Seq_HepG2_Human1.22624457
80AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.22255983
81WT1_25993318_ChIP-Seq_PODOCYTE_Human1.21243887
82ZFP281_18757296_ChIP-ChIP_E14_Mouse1.20946845
83TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20272868
84POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20272868
85FUS_26573619_Chip-Seq_HEK293_Human1.20104118
86HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.19927435
87WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.19212445
88CDX2_19796622_ChIP-Seq_MESCs_Mouse1.18484992
89TP53_16413492_ChIP-PET_HCT116_Human1.16487862
90RING1B_27294783_Chip-Seq_NPCs_Mouse1.15279372
91SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.14067453
92TCF4_23295773_ChIP-Seq_U87_Human1.13453091
93NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12728961
94ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.11075937
95RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.10588176
96PCGF2_27294783_Chip-Seq_ESCs_Mouse1.10307324
97MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10283124
98SMAD3_21741376_ChIP-Seq_ESCs_Human1.09247474
99RXR_22158963_ChIP-Seq_LIVER_Mouse1.08859976
100RUNX2_22187159_ChIP-Seq_PCA_Human1.08585921
101TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.08324262
102AR_25329375_ChIP-Seq_VCAP_Human1.06560355
103IKZF1_21737484_ChIP-ChIP_HCT116_Human1.06092931
104STAT6_21828071_ChIP-Seq_BEAS2B_Human1.05545400
105ARNT_22903824_ChIP-Seq_MCF-7_Human1.04488915
106LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04427742
107CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.04248847
108SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03815654
109TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03189617
110STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.02174361
111FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.01534101
112NANOG_18555785_Chip-Seq_ESCs_Mouse1.01332325
113PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.00226692
114TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99727759
115AHR_22903824_ChIP-Seq_MCF-7_Human0.99281232
116EP300_21415370_ChIP-Seq_HL-1_Mouse0.99227751
117ERG_21242973_ChIP-ChIP_JURKAT_Human0.98542066
118SMAD3_21741376_ChIP-Seq_HESCs_Human0.97686847
119TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97125618
120MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96724894
121* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.95109577
122SMAD4_21741376_ChIP-Seq_HESCs_Human0.93278146
123RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.92824530
124WT1_19549856_ChIP-ChIP_CCG9911_Human0.91879080
125REST_19997604_ChIP-ChIP_NEURONS_Mouse0.91090265

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003122_maternal_imprinting5.05495619
2MP0003123_paternal_imprinting3.59521625
3MP0003283_abnormal_digestive_organ3.50355938
4* MP0003121_genomic_imprinting2.77689898
5MP0009780_abnormal_chondrocyte_physiolo2.72121952
6MP0005645_abnormal_hypothalamus_physiol2.60471778
7MP0000013_abnormal_adipose_tissue2.55329700
8MP0000566_synostosis2.51348690
9MP0004859_abnormal_synaptic_plasticity2.49884765
10MP0002909_abnormal_adrenal_gland2.49437928
11MP0003787_abnormal_imprinting2.25915766
12MP0003195_calcinosis2.19458407
13MP0004270_analgesia2.15804724
14MP0003635_abnormal_synaptic_transmissio2.13756949
15MP0003880_abnormal_central_pattern2.08642040
16MP0006276_abnormal_autonomic_nervous2.01708907
17MP0010329_abnormal_lipoprotein_level1.99135344
18MP0005646_abnormal_pituitary_gland1.84461457
19MP0002139_abnormal_hepatobiliary_system1.75894427
20MP0005365_abnormal_bile_salt1.69640182
21MP0005379_endocrine/exocrine_gland_phen1.68161916
22MP0002837_dystrophic_cardiac_calcinosis1.64511827
23MP0001666_abnormal_nutrient_absorption1.63959034
24MP0004145_abnormal_muscle_electrophysio1.62038990
25MP0002063_abnormal_learning/memory/cond1.60984516
26MP0003329_amyloid_beta_deposits1.60766475
27MP0005409_darkened_coat_color1.60740123
28MP0009046_muscle_twitch1.59574340
29MP0001944_abnormal_pancreas_morphology1.59419121
30MP0002734_abnormal_mechanical_nocicepti1.58547340
31MP0010386_abnormal_urinary_bladder1.58364598
32MP0006072_abnormal_retinal_apoptosis1.56487253
33MP0002572_abnormal_emotion/affect_behav1.53103885
34MP0001299_abnormal_eye_distance/1.51538519
35MP0002064_seizures1.50259532
36MP0009745_abnormal_behavioral_response1.48116517
37MP0003879_abnormal_hair_cell1.46079190
38MP0000631_abnormal_neuroendocrine_gland1.46044789
39MP0002184_abnormal_innervation1.45781894
40MP0002089_abnormal_postnatal_growth/wei1.44051628
41MP0005423_abnormal_somatic_nervous1.41761818
42MP0010368_abnormal_lymphatic_system1.41686609
43MP0004043_abnormal_pH_regulation1.40255441
44MP0003633_abnormal_nervous_system1.39926499
45MP0003868_abnormal_feces_composition1.39139792
46MP0002234_abnormal_pharynx_morphology1.39112274
47MP0003632_abnormal_nervous_system1.37631819
48MP0002693_abnormal_pancreas_physiology1.37516038
49MP0000569_abnormal_digit_pigmentation1.37117995
50MP0004742_abnormal_vestibular_system1.37087004
51MP0000920_abnormal_myelination1.36853764
52MP0003690_abnormal_glial_cell1.36359055
53MP0003119_abnormal_digestive_system1.35910587
54MP0002272_abnormal_nervous_system1.35881891
55MP0002938_white_spotting1.34892384
56MP0002638_abnormal_pupillary_reflex1.33519661
57MP0003942_abnormal_urinary_system1.33487570
58MP0003890_abnormal_embryonic-extraembry1.32741801
59MP0003183_abnormal_peptide_metabolism1.30831377
60MP0000678_abnormal_parathyroid_gland1.30330579
61MP0000003_abnormal_adipose_tissue1.30206954
62MP0002733_abnormal_thermal_nociception1.30039883
63MP0008875_abnormal_xenobiotic_pharmacok1.29554459
64MP0000955_abnormal_spinal_cord1.28878053
65MP0003631_nervous_system_phenotype1.28573718
66MP0000778_abnormal_nervous_system1.27762105
67MP0002877_abnormal_melanocyte_morpholog1.26511501
68* MP0002557_abnormal_social/conspecific_i1.26419060
69MP0004233_abnormal_muscle_weight1.24256523
70MP0003385_abnormal_body_wall1.22870579
71MP0001501_abnormal_sleep_pattern1.21120454
72MP0001529_abnormal_vocalization1.20895488
73MP0008961_abnormal_basal_metabolism1.19773554
74MP0004885_abnormal_endolymph1.18055287
75MP0005551_abnormal_eye_electrophysiolog1.17265832
76MP0000534_abnormal_ureter_morphology1.17253834
77MP0000537_abnormal_urethra_morphology1.16811886
78MP0005360_urolithiasis1.14999738
79MP0004924_abnormal_behavior1.10426662
80MP0005386_behavior/neurological_phenoty1.10426662
81MP0001968_abnormal_touch/_nociception1.10024069
82MP0001486_abnormal_startle_reflex1.07597903
83MP0002067_abnormal_sensory_capabilities1.07148334
84MP0004264_abnormal_extraembryonic_tissu1.06772864
85MP0005167_abnormal_blood-brain_barrier1.06706027
86MP0001502_abnormal_circadian_rhythm1.05682160
87MP0000462_abnormal_digestive_system1.05049402
88MP0001970_abnormal_pain_threshold1.03226453
89MP0005187_abnormal_penis_morphology1.00432999
90MP0004811_abnormal_neuron_physiology0.99921968
91MP0003136_yellow_coat_color0.97845358
92MP0003315_abnormal_perineum_morphology0.97420179
93MP0004272_abnormal_basement_membrane0.96622452
94MP0000428_abnormal_craniofacial_morphol0.95950680
95MP0010030_abnormal_orbit_morphology0.95728538
96MP0002751_abnormal_autonomic_nervous0.95545715
97MP0002882_abnormal_neuron_morphology0.95014127
98MP0001270_distended_abdomen0.94308108
99MP0003959_abnormal_lean_body0.93825289
100MP0003634_abnormal_glial_cell0.93355805
101MP0002163_abnormal_gland_morphology0.92810397
102MP0009703_decreased_birth_body0.92100090
103MP0001440_abnormal_grooming_behavior0.90796266
104MP0002229_neurodegeneration0.90623829
105MP0005085_abnormal_gallbladder_physiolo0.90315034
106MP0001177_atelectasis0.89791283
107MP0002896_abnormal_bone_mineralization0.89644621
108MP0002078_abnormal_glucose_homeostasis0.88153954
109* MP0002152_abnormal_brain_morphology0.87186619
110MP0000049_abnormal_middle_ear0.86717912
111MP0002116_abnormal_craniofacial_bone0.85628164
112MP0003935_abnormal_craniofacial_develop0.83958003
113MP0002177_abnormal_outer_ear0.83394140
114MP0005220_abnormal_exocrine_pancreas0.83320712
115MP0001915_intracranial_hemorrhage0.83238836
116MP0008569_lethality_at_weaning0.82815644
117MP0009250_abnormal_appendicular_skeleto0.82607382
118MP0002066_abnormal_motor_capabilities/c0.82339337
119MP0001984_abnormal_olfaction0.82007525
120MP0003172_abnormal_lysosome_physiology0.80401488
121MP0002160_abnormal_reproductive_system0.79884192
122MP0002735_abnormal_chemical_nociception0.79466466
123MP0003755_abnormal_palate_morphology0.79092912
124MP0009053_abnormal_anal_canal0.77779202
125MP0003115_abnormal_respiratory_system0.77626521
126MP0000639_abnormal_adrenal_gland0.77415480
127MP0003567_abnormal_fetal_cardiomyocyte0.77397077
128MP0003937_abnormal_limbs/digits/tail_de0.76705521
129MP0000604_amyloidosis0.76696892
130MP0002736_abnormal_nociception_after0.76451900
131MP0003861_abnormal_nervous_system0.76363554
132MP0005410_abnormal_fertilization0.75763342
133MP0009672_abnormal_birth_weight0.75321912
134MP0005248_abnormal_Harderian_gland0.74994597
135MP0002118_abnormal_lipid_homeostasis0.74651514
136MP0002069_abnormal_eating/drinking_beha0.73992365
137MP0006292_abnormal_olfactory_placode0.72946048
138MP0004858_abnormal_nervous_system0.71480449
139MP0001963_abnormal_hearing_physiology0.70516953
140MP0003698_abnormal_male_reproductive0.69253551
141MP0003953_abnormal_hormone_level0.69197552
142MP0003878_abnormal_ear_physiology0.67746598
143MP0005377_hearing/vestibular/ear_phenot0.67746598
144MP0001485_abnormal_pinna_reflex0.66265425
145MP0008877_abnormal_DNA_methylation0.62520695
146MP0003252_abnormal_bile_duct0.61916024

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.50895670
2Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.77790771
3Prolonged partial thromboplastin time (HP:0003645)4.31221029
4Hyperinsulinemic hypoglycemia (HP:0000825)3.74863201
5Hypoglycemic seizures (HP:0002173)3.73998210
6Hepatoblastoma (HP:0002884)3.56233420
7Agitation (HP:0000713)3.50964697
8Hypobetalipoproteinemia (HP:0003563)3.48593236
9Small epiphyses (HP:0010585)3.43014959
10Joint hemorrhage (HP:0005261)3.34894594
11Complement deficiency (HP:0004431)3.27213324
12Symptomatic seizures (HP:0011145)3.23874057
13Pancreatic islet-cell hyperplasia (HP:0004510)3.20604338
14Abnormal pancreas size (HP:0012094)3.15123206
15Abnormality of calcium-phosphate metabolism (HP:0100530)3.14532077
16Epidermoid cyst (HP:0200040)3.10065654
17Abnormality of endocrine pancreas physiology (HP:0012093)2.93298056
18Abnormality of the pancreatic islet cells (HP:0006476)2.93298056
19Visual hallucinations (HP:0002367)2.92873997
20Abnormality of the common coagulation pathway (HP:0010990)2.90428738
21Alacrima (HP:0000522)2.90310754
22Macroorchidism (HP:0000053)2.83137007
23Hypercholesterolemia (HP:0003124)2.73557283
24Focal motor seizures (HP:0011153)2.73078426
25Broad palm (HP:0001169)2.72409418
26Failure to thrive in infancy (HP:0001531)2.72329764
27Sex reversal (HP:0012245)2.72137421
28Abnormal sex determination (HP:0012244)2.72137421
29Hyperglycemia (HP:0003074)2.67237792
30Acanthocytosis (HP:0001927)2.67087832
31Bronchomalacia (HP:0002780)2.63332998
32Pheochromocytoma (HP:0002666)2.62219805
33Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.61592489
34Abnormality of carpal bone ossification (HP:0006257)2.60375119
35Renal duplication (HP:0000075)2.59560524
36Scanning speech (HP:0002168)2.55216761
37Broad alveolar ridges (HP:0000187)2.53518538
38Glomerulonephritis (HP:0000099)2.51850648
39Neonatal short-limb short stature (HP:0008921)2.50905826
40Xanthomatosis (HP:0000991)2.50765780
41Neurofibrillary tangles (HP:0002185)2.48115875
42Spontaneous abortion (HP:0005268)2.45925381
43Neoplasm of the heart (HP:0100544)2.44941695
44Bifid tongue (HP:0010297)2.44917962
45Menstrual irregularities (HP:0000858)2.44567134
46Focal seizures (HP:0007359)2.43360904
47EEG with generalized epileptiform discharges (HP:0011198)2.40149827
48Abnormality of the pubic bones (HP:0003172)2.38319856
49Atonic seizures (HP:0010819)2.36705826
50Hypsarrhythmia (HP:0002521)2.33581522
51Epileptiform EEG discharges (HP:0011182)2.32369965
52Gonadal dysgenesis (HP:0000133)2.29464222
53Abnormality of the nasal septum (HP:0000419)2.26865172
54Renal salt wasting (HP:0000127)2.25174679
55Akinesia (HP:0002304)2.23383430
56Status epilepticus (HP:0002133)2.22334504
57Progressive cerebellar ataxia (HP:0002073)2.22324940
58Abnormal hand bone ossification (HP:0010660)2.22324509
59Decreased lacrimation (HP:0000633)2.21489971
60Papilledema (HP:0001085)2.19715883
61Neuroendocrine neoplasm (HP:0100634)2.16097330
62Papillary thyroid carcinoma (HP:0002895)2.15938275
63Abnormality of aromatic amino acid family metabolism (HP:0004338)2.13846724
64Absence seizures (HP:0002121)2.10915898
65Abnormal tarsal ossification (HP:0008369)2.10737916
66Asymmetry of the thorax (HP:0001555)2.09672948
67Irregular epiphyses (HP:0010582)2.08623129
68Hypolipoproteinemia (HP:0010981)2.08302751
69Insulin-resistant diabetes mellitus (HP:0000831)2.07969465
70Arthropathy (HP:0003040)2.07859030
71Hypoventilation (HP:0002791)2.07137930
72Abnormal ossification of hand bones (HP:0005921)2.06803061
73Depression (HP:0000716)2.06113661
74Labial hypoplasia (HP:0000066)2.06024073
75Abnormality of the wing of the ilium (HP:0011867)2.05377429
76Cutaneous finger syndactyly (HP:0010554)1.99602639
77Broad thumb (HP:0011304)1.99245670
78Limb dystonia (HP:0002451)1.97803764
79Epileptic encephalopathy (HP:0200134)1.96762142
80Bifid scrotum (HP:0000048)1.96447201
81Hypoglycemic coma (HP:0001325)1.95960388
82Vaginal fistula (HP:0004320)1.94632949
83Heterotopia (HP:0002282)1.93957649
84Action tremor (HP:0002345)1.92305922
85Abnormality of complement system (HP:0005339)1.91600195
86Cerebral inclusion bodies (HP:0100314)1.91580190
87Hypoplasia of the capital femoral epiphysis (HP:0003090)1.90688987
88Megalencephaly (HP:0001355)1.89388311
89Limited elbow extension (HP:0001377)1.89186159
90Skin nodule (HP:0200036)1.87058526
91Menorrhagia (HP:0000132)1.86790579
92Generalized tonic-clonic seizures (HP:0002069)1.86682038
93Anteriorly placed anus (HP:0001545)1.86633311
94Potter facies (HP:0002009)1.86588847
95Facial shape deformation (HP:0011334)1.86588847
96Decreased circulating renin level (HP:0003351)1.86441841
97Mitral stenosis (HP:0001718)1.86337647
98Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.85031581
99Absent epiphyses (HP:0010577)1.85031581
100Absent eyebrow (HP:0002223)1.83754722
101Large for gestational age (HP:0001520)1.83274118
102Cutaneous syndactyly (HP:0012725)1.82632841
103Flat acetabular roof (HP:0003180)1.82092263
104Anxiety (HP:0000739)1.81035508
105Impaired smooth pursuit (HP:0007772)1.80234224
106Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.80135310
107Short 4th metacarpal (HP:0010044)1.80135310
108Postural tremor (HP:0002174)1.79019027
109Restlessness (HP:0000711)1.78753468
110Truncal ataxia (HP:0002078)1.78681369
111Hypothermia (HP:0002045)1.78524263
112Turricephaly (HP:0000262)1.78107541
113Abnormal social behavior (HP:0012433)1.77518942
114Impaired social interactions (HP:0000735)1.77518942
115Genetic anticipation (HP:0003743)1.77399772
116Aplasia involving bones of the extremities (HP:0009825)1.76978763
117Aplasia involving bones of the upper limbs (HP:0009823)1.76978763
118Aplasia of the phalanges of the hand (HP:0009802)1.76978763
119Urinary bladder sphincter dysfunction (HP:0002839)1.74303398
120Hypoplastic female external genitalia (HP:0012815)1.74227409
121Hypokalemia (HP:0002900)1.72329957
122Congenital glaucoma (HP:0001087)1.71978282
123Amblyopia (HP:0000646)1.71728724
124Excessive salivation (HP:0003781)1.71290183
125Drooling (HP:0002307)1.71290183
126Broad finger (HP:0001500)1.70571375
127Impaired pain sensation (HP:0007328)1.70429288
128Abnormality of pain sensation (HP:0010832)1.70429288
129Broad phalanges of the hand (HP:0009768)1.69482204
130Hyperaldosteronism (HP:0000859)1.68939289
131Gastroesophageal reflux (HP:0002020)1.68823791
132Osteomalacia (HP:0002749)1.68752358
133Febrile seizures (HP:0002373)1.68205009
134Dialeptic seizures (HP:0011146)1.67174581
135Broad phalanx (HP:0006009)1.66874362
136Hypercortisolism (HP:0001578)1.66492016
137Postural instability (HP:0002172)1.66098895
138Flared iliac wings (HP:0002869)1.65817954
139Hemiparesis (HP:0001269)1.65553750
140Enlarged penis (HP:0000040)1.64800905
141Dysdiadochokinesis (HP:0002075)1.64272673
142Ankyloglossia (HP:0010296)1.64226052
143Myokymia (HP:0002411)1.63629206
144Diplopia (HP:0000651)1.63379465
145Abnormality of binocular vision (HP:0011514)1.63379465
146Epiphyseal dysplasia (HP:0002656)1.63232539
147Hypoplastic labia majora (HP:0000059)1.61280455
148Supranuclear gaze palsy (HP:0000605)1.60699767
149Open mouth (HP:0000194)1.60607769
150Ankle clonus (HP:0011448)1.59963138
151Blue irides (HP:0000635)1.59771122
152Midline defect of the nose (HP:0004122)1.59060840
153Ectopic anus (HP:0004397)1.57367182
154Hypoplastic ischia (HP:0003175)1.55860195
155Ketoacidosis (HP:0001993)1.52790047
156Broad long bones (HP:0005622)1.51879162
157Hyperthyroidism (HP:0000836)1.51847034
158Abnormality of the metopic suture (HP:0005556)1.51544430
159Genital tract atresia (HP:0001827)1.51516562
160Enlarged kidneys (HP:0000105)1.51458313
161Vaginal atresia (HP:0000148)1.51439859
162Macroglossia (HP:0000158)1.50030142
163Retinal atrophy (HP:0001105)1.50001101
164Insomnia (HP:0100785)1.50000705
165Hyperparathyroidism (HP:0000843)1.49754792
166Missing ribs (HP:0000921)1.49030469
167Abnormality of the labia majora (HP:0012881)1.48386488
168Downturned corners of mouth (HP:0002714)1.48185975
169Abnormality of midbrain morphology (HP:0002418)1.47800986
170Molar tooth sign on MRI (HP:0002419)1.47800986
171Testicular neoplasm (HP:0010788)1.47521879
172Narrow nasal bridge (HP:0000446)1.47251377
173Aplasia/Hypoplasia of metatarsal bones (HP:0001964)1.46628386

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.09584103
2WNK33.94727022
3INSRR3.78911189
4FGFR32.79761523
5FGFR42.78145018
6PASK2.77485356
7PRKD32.57685456
8MAPK152.53405635
9MAP3K42.38828287
10UHMK12.23315949
11NTRK12.02718904
12MINK11.90897007
13ICK1.90448216
14MARK11.88727331
15MAP3K91.88522719
16PNCK1.87479479
17SIK21.81843600
18KSR11.81326326
19PDGFRA1.77667682
20NTRK21.64305567
21MAP3K21.62469101
22BCR1.60639942
23CAMK1G1.54723149
24AKT31.54702643
25CDC42BPA1.53895900
26MAP2K71.51524600
27PAK31.49137568
28CDK121.43532408
29WNK41.43457102
30PAK61.41226358
31MAP2K41.38183723
32WNK11.34138930
33SCYL21.31664382
34PIK3CA1.30578824
35HIPK21.29728112
36BRD41.24990672
37LATS11.20497957
38ERBB31.18301566
39MAP3K121.16966275
40FRK1.15122904
41LATS21.13865588
42SIK31.07230539
43MAPK131.06086824
44CAMKK21.04132658
45DDR21.03479167
46STK391.02926159
47FER1.02287972
48PRKCH1.00423383
49CDK50.93861064
50KSR20.93608993
51PTK20.93027540
52CAMK1D0.92363020
53STK380.90439509
54EPHA40.90130473
55PINK10.86799074
56EPHB20.82366892
57CSNK1G20.82216957
58SGK20.81930413
59SGK2230.81564128
60SGK4940.81564128
61CAMKK10.79540036
62PRKCG0.79194101
63RET0.76206226
64PDK10.75859622
65MAP3K10.73094529
66PDPK10.71941880
67DYRK1A0.70455559
68PHKG20.68604077
69PHKG10.68604077
70PLK20.66751517
71CDK140.66600394
72CDK180.66345518
73MAPK100.64142200
74FGFR10.63989136
75CAMK2A0.63908629
76PRKCZ0.62824798
77PTK60.62735821
78SGK10.61557851
79YES10.60739978
80CAMK10.59927173
81ADRBK10.59894978
82SGK30.59837572
83PRKCE0.59627301
84MTOR0.58899950
85CSNK1G30.58586899
86CDK150.58137713
87CSNK1A1L0.57557244
88PRKAA20.57451756
89CAMK2D0.56908009
90CAMK40.56907680
91PLK30.56172743
92CASK0.55236428
93TNIK0.54316046
94ALK0.54287045
95RPS6KA30.53451643
96CSNK1D0.53278067
97NEK60.52922821
98GRK50.51969455
99EEF2K0.51744612
100ERBB20.50155569
101TYRO30.50038158
102CSNK1E0.49959838
103CAMK2B0.49429061
104PRKAA10.49051013
105DAPK20.48191690
106PRKG10.47523896
107DAPK10.47422329
108CDK11A0.47390186
109PRKDC0.46168414
110SIK10.45914957
111FGFR20.45235512
112BRSK10.45103963
113RPS6KA20.44349431
114GRK70.44209439
115CSNK1G10.44050197
116MARK20.43170318
117RIPK10.42006575
118FGR0.41999380
119IRAK20.41808885
120GSK3B0.41803487
121PDGFRB0.41602562
122MAPKAPK50.41246685
123PIK3CG0.40726370
124CSNK1A10.40590787
125RPS6KB10.39947030
126MAPK140.39636616
127CCNB10.39384875
128CDK30.38926444
129DYRK1B0.38566155
130PKN10.37261516
131PKN20.35637626
132MAPK80.33606247
133BMPR1B0.33593066
134STK110.33442512

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.05126266
2Insulin secretion_Homo sapiens_hsa049113.13916502
3Complement and coagulation cascades_Homo sapiens_hsa046102.84290865
4Nicotine addiction_Homo sapiens_hsa050332.59965564
5Synaptic vesicle cycle_Homo sapiens_hsa047212.38111571
6GABAergic synapse_Homo sapiens_hsa047272.37230507
7Cocaine addiction_Homo sapiens_hsa050302.35121404
8Fatty acid biosynthesis_Homo sapiens_hsa000612.32229662
9Amphetamine addiction_Homo sapiens_hsa050312.28306876
10Steroid biosynthesis_Homo sapiens_hsa001002.21859666
11Type II diabetes mellitus_Homo sapiens_hsa049302.12275760
12Circadian entrainment_Homo sapiens_hsa047132.09792475
13Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.09308128
14Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.01828226
15Protein export_Homo sapiens_hsa030601.99770714
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.99220365
17Long-term potentiation_Homo sapiens_hsa047201.97377409
18Dopaminergic synapse_Homo sapiens_hsa047281.95856544
19Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.88208652
20Morphine addiction_Homo sapiens_hsa050321.81070410
21Taste transduction_Homo sapiens_hsa047421.75591014
22Bile secretion_Homo sapiens_hsa049761.70432900
23Vibrio cholerae infection_Homo sapiens_hsa051101.70089868
24Fat digestion and absorption_Homo sapiens_hsa049751.61775382
25Serotonergic synapse_Homo sapiens_hsa047261.61076859
26Glutamatergic synapse_Homo sapiens_hsa047241.60303960
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.59505237
28Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.58427639
29Vitamin B6 metabolism_Homo sapiens_hsa007501.57001559
30Type I diabetes mellitus_Homo sapiens_hsa049401.54822073
31Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.54702222
32Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.48272641
33Cholinergic synapse_Homo sapiens_hsa047251.47731206
34Histidine metabolism_Homo sapiens_hsa003401.47086193
35Hedgehog signaling pathway_Homo sapiens_hsa043401.41337908
36Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.40610822
37Olfactory transduction_Homo sapiens_hsa047401.39662219
38Renin secretion_Homo sapiens_hsa049241.35988862
39Long-term depression_Homo sapiens_hsa047301.35666897
40Fatty acid metabolism_Homo sapiens_hsa012121.34839515
41Melanogenesis_Homo sapiens_hsa049161.30605570
42Estrogen signaling pathway_Homo sapiens_hsa049151.28403445
43Thyroid hormone synthesis_Homo sapiens_hsa049181.26086141
44Arginine biosynthesis_Homo sapiens_hsa002201.25603655
45Vitamin digestion and absorption_Homo sapiens_hsa049771.24853785
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.24626358
47Salivary secretion_Homo sapiens_hsa049701.19393597
48PPAR signaling pathway_Homo sapiens_hsa033201.18427278
49Gap junction_Homo sapiens_hsa045401.15499926
50Gastric acid secretion_Homo sapiens_hsa049711.13731684
51ABC transporters_Homo sapiens_hsa020101.12929416
52Basal cell carcinoma_Homo sapiens_hsa052171.08593217
53Axon guidance_Homo sapiens_hsa043601.06288231
54Glucagon signaling pathway_Homo sapiens_hsa049221.05858935
55cAMP signaling pathway_Homo sapiens_hsa040241.05752483
56Wnt signaling pathway_Homo sapiens_hsa043101.03113192
57GnRH signaling pathway_Homo sapiens_hsa049121.02160745
58Oxytocin signaling pathway_Homo sapiens_hsa049211.01676185
59Carbohydrate digestion and absorption_Homo sapiens_hsa049731.01629408
60Fatty acid degradation_Homo sapiens_hsa000711.01626509
61Alcoholism_Homo sapiens_hsa050341.00164460
62Pancreatic secretion_Homo sapiens_hsa049720.99988030
63Steroid hormone biosynthesis_Homo sapiens_hsa001400.99642040
64cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99478573
65Oocyte meiosis_Homo sapiens_hsa041140.98407743
66Circadian rhythm_Homo sapiens_hsa047100.98256358
67Collecting duct acid secretion_Homo sapiens_hsa049660.97740479
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.95050643
69Dorso-ventral axis formation_Homo sapiens_hsa043200.93322734
70Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93252324
71Dilated cardiomyopathy_Homo sapiens_hsa054140.93063590
72Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.90846926
73Butanoate metabolism_Homo sapiens_hsa006500.90585625
74Calcium signaling pathway_Homo sapiens_hsa040200.89720768
75Sulfur metabolism_Homo sapiens_hsa009200.89030956
76Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.88348540
77Hippo signaling pathway_Homo sapiens_hsa043900.86620000
78Vascular smooth muscle contraction_Homo sapiens_hsa042700.86365521
79Arginine and proline metabolism_Homo sapiens_hsa003300.85364057
80N-Glycan biosynthesis_Homo sapiens_hsa005100.82569447
81Nitrogen metabolism_Homo sapiens_hsa009100.80362978
82Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.79347092
83Cardiac muscle contraction_Homo sapiens_hsa042600.79312681
84Propanoate metabolism_Homo sapiens_hsa006400.76098042
85Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.72953108
86ErbB signaling pathway_Homo sapiens_hsa040120.72908257
87Glioma_Homo sapiens_hsa052140.72764503
88Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72716921
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.72349692
90Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70916538
91Mineral absorption_Homo sapiens_hsa049780.67882798
92Insulin signaling pathway_Homo sapiens_hsa049100.67006971
93Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.66942363
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66601572
95mTOR signaling pathway_Homo sapiens_hsa041500.66482529
96Endometrial cancer_Homo sapiens_hsa052130.64972065
97Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64718556
98Prion diseases_Homo sapiens_hsa050200.64495631
99Phenylalanine metabolism_Homo sapiens_hsa003600.63229154
100ECM-receptor interaction_Homo sapiens_hsa045120.61974599
101Neurotrophin signaling pathway_Homo sapiens_hsa047220.61511478
102Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61013073
103MAPK signaling pathway_Homo sapiens_hsa040100.56600018
104Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56427920
105Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.54784299
106Protein digestion and absorption_Homo sapiens_hsa049740.54280334
107Renal cell carcinoma_Homo sapiens_hsa052110.53853740
108Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52826732
109Ovarian steroidogenesis_Homo sapiens_hsa049130.49675176
110Renin-angiotensin system_Homo sapiens_hsa046140.49199583
111Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48957086
112Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.48707510
113Glycerolipid metabolism_Homo sapiens_hsa005610.48660614
114Lysine degradation_Homo sapiens_hsa003100.48448302
115SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46419743
116Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.46124623
117Starch and sucrose metabolism_Homo sapiens_hsa005000.45293050
118Tight junction_Homo sapiens_hsa045300.44912031
1192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.44665942
120Prolactin signaling pathway_Homo sapiens_hsa049170.44410963
121Phospholipase D signaling pathway_Homo sapiens_hsa040720.44091551
122AMPK signaling pathway_Homo sapiens_hsa041520.43495227
123Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42732417
124Insulin resistance_Homo sapiens_hsa049310.42565797
125Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.42196925
126Proteoglycans in cancer_Homo sapiens_hsa052050.41984712
127beta-Alanine metabolism_Homo sapiens_hsa004100.40656882
128Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40193808
129Adherens junction_Homo sapiens_hsa045200.39227137
130Prostate cancer_Homo sapiens_hsa052150.38349085
131Colorectal cancer_Homo sapiens_hsa052100.38242250
132Ras signaling pathway_Homo sapiens_hsa040140.37969554
133Choline metabolism in cancer_Homo sapiens_hsa052310.37352147
134mRNA surveillance pathway_Homo sapiens_hsa030150.36831922
135Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.36345008
136Inositol phosphate metabolism_Homo sapiens_hsa005620.36003243

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