PEF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a calcium-binding protein belonging to the penta-EF-hand protein family. The encoded protein has been shown to form a heterodimer with the programmed cell death 6 gene product and may modulate its function in Ca(2+) signaling. Alternative splicing results in multiple transcript variants and a pseudogene has been identified on chromosome 1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein maturation by protein folding (GO:0022417)5.61246861
2pentose-phosphate shunt (GO:0006098)4.47319007
3COPI coating of Golgi vesicle (GO:0048205)4.25331932
4Golgi transport vesicle coating (GO:0048200)4.25331932
5sulfur amino acid catabolic process (GO:0000098)4.17216430
6NADPH regeneration (GO:0006740)4.13151259
7positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.01549338
8regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.88992485
9NADH metabolic process (GO:0006734)3.86681763
10metallo-sulfur cluster assembly (GO:0031163)3.85946455
11iron-sulfur cluster assembly (GO:0016226)3.85946455
12DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.79585714
13regulation of mitochondrial translation (GO:0070129)3.72912002
14anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.71360125
15mitotic nuclear envelope reassembly (GO:0007084)3.69903360
16nuclear envelope reassembly (GO:0031468)3.69903360
17signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.69419403
18intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.69419403
19establishment of viral latency (GO:0019043)3.67048546
20signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.65882132
21signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.65882132
22signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.65882132
23deoxyribose phosphate biosynthetic process (GO:0046385)3.65459480
242-deoxyribonucleotide biosynthetic process (GO:0009265)3.65459480
25mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.60946891
26erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.60771757
27L-phenylalanine metabolic process (GO:0006558)3.60771757
28guanosine-containing compound biosynthetic process (GO:1901070)3.59722586
29peptidyl-arginine omega-N-methylation (GO:0035247)3.59672452
30signal transduction involved in DNA integrity checkpoint (GO:0072401)3.57227724
31signal transduction involved in DNA damage checkpoint (GO:0072422)3.57227724
32protein deneddylation (GO:0000338)3.56504396
33cullin deneddylation (GO:0010388)3.54843575
34positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.50460856
35GDP-mannose metabolic process (GO:0019673)3.49596618
36signal transduction involved in cell cycle checkpoint (GO:0072395)3.47626910
37galactose catabolic process (GO:0019388)3.46928190
38valine metabolic process (GO:0006573)3.46921441
39oxidative phosphorylation (GO:0006119)3.38705930
40positive regulation of ligase activity (GO:0051351)3.35679683
41ATP synthesis coupled proton transport (GO:0015986)3.35605138
42energy coupled proton transport, down electrochemical gradient (GO:0015985)3.35605138
43nucleoside salvage (GO:0043174)3.34475444
44establishment of integrated proviral latency (GO:0075713)3.32482422
45tricarboxylic acid cycle (GO:0006099)3.30223682
46cysteine metabolic process (GO:0006534)3.29361673
47DNA deamination (GO:0045006)3.27424348
48quinone biosynthetic process (GO:1901663)3.23953255
49ubiquinone biosynthetic process (GO:0006744)3.23953255
50purine nucleotide salvage (GO:0032261)3.21367835
51erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.19502286
52L-phenylalanine catabolic process (GO:0006559)3.19502286
53protein targeting to mitochondrion (GO:0006626)3.19301863
54GMP metabolic process (GO:0046037)3.18817964
55regulation of ubiquitin-protein transferase activity (GO:0051438)3.17594005
56proline biosynthetic process (GO:0006561)3.15603460
57vitamin transmembrane transport (GO:0035461)3.14377595
58deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.13587537
59aldehyde catabolic process (GO:0046185)3.10909441
60pyrimidine-containing compound salvage (GO:0008655)3.10760289
61pyrimidine nucleoside salvage (GO:0043097)3.10760289
62lysine catabolic process (GO:0006554)3.09953937
63lysine metabolic process (GO:0006553)3.09953937
64glucose catabolic process (GO:0006007)3.09114321
65GTP biosynthetic process (GO:0006183)3.07649877
66regulation of ligase activity (GO:0051340)3.06558936
67tricarboxylic acid metabolic process (GO:0072350)3.06038994
68regulation of cellular amine metabolic process (GO:0033238)3.05021052
69regulation of cellular amino acid metabolic process (GO:0006521)3.04852198
70nucleoside diphosphate biosynthetic process (GO:0009133)3.01914178
71pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.01594682
72electron transport chain (GO:0022900)3.00642542
73pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.00621886
74respiratory electron transport chain (GO:0022904)3.00413245
75peptidyl-arginine methylation (GO:0018216)2.99453617
76peptidyl-arginine N-methylation (GO:0035246)2.99453617
77pyrimidine-containing compound transmembrane transport (GO:0072531)2.96766247
78fructose metabolic process (GO:0006000)2.96120090
79oxaloacetate metabolic process (GO:0006107)2.95295383
80deoxyribonucleotide biosynthetic process (GO:0009263)2.93944024
81cellular metabolic compound salvage (GO:0043094)2.93274764
82pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.92574255
83establishment of protein localization to mitochondrion (GO:0072655)2.91924236
84UTP biosynthetic process (GO:0006228)2.91853266
85regulation of cholesterol metabolic process (GO:0090181)2.91091906
86pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.90706946
87antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.90232222
88negative regulation of protein ubiquitination (GO:0031397)2.89679519
89heme biosynthetic process (GO:0006783)2.87878723
90negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.87837452
91nucleobase-containing small molecule interconversion (GO:0015949)2.86955281
92viral transcription (GO:0019083)2.86680888
93positive regulation of cell cycle arrest (GO:0071158)2.86674463
94L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.86278889
95establishment of protein localization to mitochondrial membrane (GO:0090151)2.85654499
96L-methionine salvage (GO:0071267)2.85393634
97L-methionine biosynthetic process (GO:0071265)2.85393634
98amino acid salvage (GO:0043102)2.85393634
99base-excision repair, AP site formation (GO:0006285)2.85163701
100CTP biosynthetic process (GO:0006241)2.85141494
101CTP metabolic process (GO:0046036)2.85141494
102ubiquinone metabolic process (GO:0006743)2.84351057
103succinate metabolic process (GO:0006105)2.82833644
104negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.80868171
105histone arginine methylation (GO:0034969)2.80619231
106protein localization to mitochondrion (GO:0070585)2.79605502
107nucleotide salvage (GO:0043173)2.79594013
108protein retention in ER lumen (GO:0006621)2.79473033
109ethanol oxidation (GO:0006069)2.78254229
110deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.77531462
111DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.77208664
112deoxyribonucleotide catabolic process (GO:0009264)2.75593157
113deoxyribose phosphate catabolic process (GO:0046386)2.75536184
114pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.74983296
115glyoxylate metabolic process (GO:0046487)2.74617291
116branched-chain amino acid catabolic process (GO:0009083)2.73911345
117translational termination (GO:0006415)2.73774320
118NADP metabolic process (GO:0006739)2.73537762
119ribosomal small subunit assembly (GO:0000028)2.73179616
120primary alcohol catabolic process (GO:0034310)2.72988686
121fatty acid beta-oxidation (GO:0006635)2.72804975
122aromatic amino acid family catabolic process (GO:0009074)2.72697820
123regulation of proton transport (GO:0010155)2.72497379
124rRNA modification (GO:0000154)2.72458122
125translational elongation (GO:0006414)2.71715891
126monosaccharide biosynthetic process (GO:0046364)2.70631119
127heme transport (GO:0015886)2.70591560
128UTP metabolic process (GO:0046051)2.70196136
129negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.70049006
130antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.69552421
131bile acid and bile salt transport (GO:0015721)2.69344910
132maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.69048930
133de novo protein folding (GO:0006458)2.68939979
134deoxyribose phosphate metabolic process (GO:0019692)2.68716283
135kynurenine metabolic process (GO:0070189)2.68614375
136de novo posttranslational protein folding (GO:0051084)2.68358122
137purine nucleobase biosynthetic process (GO:0009113)2.68137318
138ribosome assembly (GO:0042255)2.67875313
139mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.67360915
140chaperone-mediated protein transport (GO:0072321)2.67266849
1412-deoxyribonucleotide metabolic process (GO:0009394)2.67210941
142serine family amino acid biosynthetic process (GO:0009070)2.66532725
1432-oxoglutarate metabolic process (GO:0006103)2.65827932
144heme metabolic process (GO:0042168)2.65810419
145iron coordination entity transport (GO:1901678)2.64602932
146protein complex biogenesis (GO:0070271)2.64028910
147alpha-linolenic acid metabolic process (GO:0036109)2.63553082
148DNA strand elongation involved in DNA replication (GO:0006271)2.62110069
149ADP metabolic process (GO:0046031)2.61821462
150hexose catabolic process (GO:0019320)2.61246983
151sulfur amino acid metabolic process (GO:0000096)2.60715447
152fatty acid oxidation (GO:0019395)2.60620112
153negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.60501648
154folic acid transport (GO:0015884)2.60352667
155ethanol metabolic process (GO:0006067)2.60012484
156amino-acid betaine metabolic process (GO:0006577)2.58826450
157lipid oxidation (GO:0034440)2.58663552
158branched-chain amino acid metabolic process (GO:0009081)2.58408776
159fatty acid catabolic process (GO:0009062)2.57949285
160purine-containing compound salvage (GO:0043101)2.56040754
161regulation of oxidative phosphorylation (GO:0002082)2.55835541
162regulation of histone phosphorylation (GO:0033127)2.55157926
163formation of translation preinitiation complex (GO:0001731)2.53045527
164fat-soluble vitamin biosynthetic process (GO:0042362)2.51432839
165acetyl-CoA metabolic process (GO:0006084)2.51124428
166proteasome assembly (GO:0043248)2.50820819
167negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.49817002
168negative regulation of ligase activity (GO:0051352)2.49817002
169SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.49752967
170hexose biosynthetic process (GO:0019319)2.49518486
171response to misfolded protein (GO:0051788)2.49108980
172antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.48668148
173cellular ketone body metabolic process (GO:0046950)2.47899863
174oxidoreduction coenzyme metabolic process (GO:0006733)2.47284282
175modified amino acid transport (GO:0072337)2.46924519

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.44301485
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.19958506
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.00166560
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.03495344
5RXR_22158963_ChIP-Seq_LIVER_Mouse2.67639579
6PPARA_22158963_ChIP-Seq_LIVER_Mouse2.66896225
7* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.53089184
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.35697995
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.33337469
10E2F7_22180533_ChIP-Seq_HELA_Human2.30436207
11* ETS1_20019798_ChIP-Seq_JURKAT_Human2.20892257
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.20399809
13* MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.10788072
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.09973256
15* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.08077125
16RARG_19884340_ChIP-ChIP_MEFs_Mouse2.06563527
17TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.98131771
18CREB1_15753290_ChIP-ChIP_HEK293T_Human1.96323032
19* EST1_17652178_ChIP-ChIP_JURKAT_Human1.93635592
20ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.93410776
21KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.88552915
22SRY_22984422_ChIP-ChIP_TESTIS_Rat1.85957472
23HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.79260200
24PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.78729020
25* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.73704007
26* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.69213591
27* SRF_21415370_ChIP-Seq_HL-1_Mouse1.68869681
28NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.67401381
29TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.64628072
30THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.63708309
31BP1_19119308_ChIP-ChIP_Hs578T_Human1.63100794
32FOXP3_21729870_ChIP-Seq_TREG_Human1.61659177
33CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.58732712
34* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.55466994
35LXR_22158963_ChIP-Seq_LIVER_Mouse1.55026270
36* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.54608294
37RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.54387528
38POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.53476882
39SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.53178663
40XRN2_22483619_ChIP-Seq_HELA_Human1.51822484
41LXR_22292898_ChIP-Seq_THP-1_Human1.49338248
42EGR1_23403033_ChIP-Seq_LIVER_Mouse1.49124341
43CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.48270305
44CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.48216545
45FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.47652987
46DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.44689403
47CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.43675932
48MYC_19079543_ChIP-ChIP_MESCs_Mouse1.43311900
49* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.42148393
50HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.42017180
51TFEB_21752829_ChIP-Seq_HELA_Human1.41426266
52BCL6_27268052_Chip-Seq_Bcells_Human1.40853763
53CTCF_18555785_ChIP-Seq_MESCs_Mouse1.40328454
54POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.39387896
55DCP1A_22483619_ChIP-Seq_HELA_Human1.39370187
56* GABP_19822575_ChIP-Seq_HepG2_Human1.39016950
57* TTF2_22483619_ChIP-Seq_HELA_Human1.38028875
58TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37941392
59THAP11_20581084_ChIP-Seq_MESCs_Mouse1.35021705
60* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.33609940
61STAT3_1855785_ChIP-Seq_MESCs_Mouse1.33554874
62YY1_21170310_ChIP-Seq_MESCs_Mouse1.32493111
63* CIITA_25753668_ChIP-Seq_RAJI_Human1.32072482
64* ELK3_25401928_ChIP-Seq_HUVEC_Human1.31777925
65* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.31660257
66ZNF263_19887448_ChIP-Seq_K562_Human1.30356294
67BCOR_27268052_Chip-Seq_Bcells_Human1.29911786
68VDR_21846776_ChIP-Seq_THP-1_Human1.29465473
69TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.28981930
70SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.28012671
71FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.27947881
72* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.27735427
73* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.27202138
74NANOG_18555785_ChIP-Seq_MESCs_Mouse1.27184855
75KDM5A_27292631_Chip-Seq_BREAST_Human1.27169657
76TET1_21451524_ChIP-Seq_MESCs_Mouse1.26948203
77ELF1_20517297_ChIP-Seq_JURKAT_Human1.25981986
78DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.25903939
79OCT4_18692474_ChIP-Seq_MEFs_Mouse1.25694707
80RACK7_27058665_Chip-Seq_MCF-7_Human1.24824737
81CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.23579621
82PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21490743
83FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.21272995
84HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.21059268
85* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.20664589
86HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.20087241
87* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.18933383
88MYCN_18555785_ChIP-Seq_MESCs_Mouse1.18896463
89ATF3_27146783_Chip-Seq_COLON_Human1.18653812
90TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.18388743
91SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.17674225
92TP63_17297297_ChIP-ChIP_HaCaT_Human1.16182311
93CLOCK_20551151_ChIP-Seq_293T_Human1.16049308
94* YY1_22570637_ChIP-Seq_MALME-3M_Human1.15874302
95* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.15639831
96GATA1_22383799_ChIP-Seq_G1ME_Mouse1.14895913
97ELK1_22589737_ChIP-Seq_MCF10A_Human1.14868313
98NELFA_20434984_ChIP-Seq_ESCs_Mouse1.14543011
99P68_20966046_ChIP-Seq_HELA_Human1.14324217
100* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.12366680
101* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.11799176
102EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.11634381
103VDR_23849224_ChIP-Seq_CD4+_Human1.10854008
104SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.10160527
105ELF1_17652178_ChIP-ChIP_JURKAT_Human1.09565956
106ZFX_18555785_ChIP-Seq_MESCs_Mouse1.08027043
107* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07828027
108SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.05892284
109* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.05406183
110MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.05388127
111BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04663612
112SA1_27219007_Chip-Seq_ERYTHROID_Human1.02893545
113STAT4_19710469_ChIP-ChIP_TH1__Mouse1.01559561
114CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.01331521
115YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00555543
116KLF4_18555785_ChIP-Seq_MESCs_Mouse1.00496870
117GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.00378151
118TBX5_21415370_ChIP-Seq_HL-1_Mouse0.99595727
119E2F4_17652178_ChIP-ChIP_JURKAT_Human0.99382877
120E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99323553
121CTCF_20526341_ChIP-Seq_ESCs_Human0.99073809
122CTCF_26484167_Chip-Seq_Bcells_Mouse0.98793856
123* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.98518991
124CTCF_21964334_Chip-Seq_Bcells_Human0.98272882
125IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.97584442
126PHF8_20622854_ChIP-Seq_HELA_Human0.97137076
127FOXP1_21924763_ChIP-Seq_HESCs_Human0.96307539
128LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.95355876
129PU.1_20513432_ChIP-Seq_Bcells_Mouse0.95283806
130SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.95188039
131SPI1_23547873_ChIP-Seq_NB4_Human0.95090716
132TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94410828
133CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.94282191
134STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.93859997
135ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.93529882

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis4.86724380
2MP0005360_urolithiasis4.03387020
3MP0002139_abnormal_hepatobiliary_system4.01106366
4MP0008875_abnormal_xenobiotic_pharmacok3.19114348
5MP0005085_abnormal_gallbladder_physiolo3.16577601
6MP0009840_abnormal_foam_cell3.11720525
7MP0002822_catalepsy2.92541682
8MP0003191_abnormal_cellular_cholesterol2.76829327
9MP0005365_abnormal_bile_salt2.70248623
10MP0005058_abnormal_lysosome_morphology2.65034759
11MP0006036_abnormal_mitochondrial_physio2.64061232
12MP0003656_abnormal_erythrocyte_physiolo2.60837937
13MP0008058_abnormal_DNA_repair2.58996432
14MP0005083_abnormal_biliary_tract2.51959955
15MP0005332_abnormal_amino_acid2.46904280
16MP0003186_abnormal_redox_activity2.34556347
17MP0010329_abnormal_lipoprotein_level2.32935663
18MP0004019_abnormal_vitamin_homeostasis2.15910877
19MP0003111_abnormal_nucleus_morphology2.12223126
20MP0008932_abnormal_embryonic_tissue2.10801037
21MP0001666_abnormal_nutrient_absorption2.01777897
22MP0002148_abnormal_hypersensitivity_rea2.01452476
23MP0009643_abnormal_urine_homeostasis2.01237575
24MP0008007_abnormal_cellular_replicative1.99217084
25MP0001835_abnormal_antigen_presentation1.93641278
26MP0004147_increased_porphyrin_level1.91116873
27MP0003786_premature_aging1.87870729
28MP0005636_abnormal_mineral_homeostasis1.84421863
29MP0006035_abnormal_mitochondrial_morpho1.83055955
30MP0005319_abnormal_enzyme/_coenzyme1.79220307
31MP0005584_abnormal_enzyme/coenzyme_acti1.79068073
32MP0010094_abnormal_chromosome_stability1.72365788
33MP0003011_delayed_dark_adaptation1.67190111
34MP0003329_amyloid_beta_deposits1.62817469
35MP0004858_abnormal_nervous_system1.61841796
36MP0001756_abnormal_urination1.59066606
37MP0005000_abnormal_immune_tolerance1.58349511
38MP0003077_abnormal_cell_cycle1.58256184
39MP0009785_altered_susceptibility_to1.57323284
40MP0002118_abnormal_lipid_homeostasis1.54874982
41MP0002877_abnormal_melanocyte_morpholog1.53461931
42MP0000465_gastrointestinal_hemorrhage1.53330715
43MP0001764_abnormal_homeostasis1.46634856
44MP0000609_abnormal_liver_physiology1.35486720
45MP0004510_myositis1.34036227
46MP0000681_abnormal_thyroid_gland1.33837247
47MP0001727_abnormal_embryo_implantation1.33635439
48MP0003646_muscle_fatigue1.33218063
49MP0001873_stomach_inflammation1.30230861
50MP0003878_abnormal_ear_physiology1.30150629
51MP0005377_hearing/vestibular/ear_phenot1.30150629
52MP0006054_spinal_hemorrhage1.28784034
53MP0005623_abnormal_meninges_morphology1.27568957
54MP0002132_abnormal_respiratory_system1.25672891
55MP0000604_amyloidosis1.25028637
56MP0001986_abnormal_taste_sensitivity1.24538328
57MP0008872_abnormal_physiological_respon1.24509526
58MP0008260_abnormal_autophagy1.24433826
59MP0001661_extended_life_span1.23457790
60MP0003075_altered_response_to1.23077168
61MP0003303_peritoneal_inflammation1.21913959
62MP0005671_abnormal_response_to1.19903204
63MP0001533_abnormal_skeleton_physiology1.18399817
64MP0005501_abnormal_skin_physiology1.15665811
65MP0006082_CNS_inflammation1.15405536
66MP0005451_abnormal_body_composition1.14857185
67MP0010368_abnormal_lymphatic_system1.14253394
68MP0000013_abnormal_adipose_tissue1.13937551
69MP0001243_abnormal_dermal_layer1.13527117
70MP0004130_abnormal_muscle_cell1.13504507
71MP0002254_reproductive_system_inflammat1.13504003
72MP0003724_increased_susceptibility_to1.13489841
73MP0010234_abnormal_vibrissa_follicle1.13351477
74MP0000313_abnormal_cell_death1.12379329
75MP0004043_abnormal_pH_regulation1.11394095
76MP0000358_abnormal_cell_content/1.11066574
77MP0002419_abnormal_innate_immunity1.10508870
78MP0002736_abnormal_nociception_after1.09644978
79MP0002723_abnormal_immune_serum1.09444389
80MP0008469_abnormal_protein_level1.08249745
81MP0001663_abnormal_digestive_system1.07537094
82MP0009697_abnormal_copulation1.07078215
83MP0001542_abnormal_bone_strength1.06892815
84MP0009763_increased_sensitivity_to1.06239384
85MP0005670_abnormal_white_adipose1.05945820
86MP0002733_abnormal_thermal_nociception1.05469166
87MP0005167_abnormal_blood-brain_barrier1.03634482
88MP0003866_abnormal_defecation1.03547597
89MP0001765_abnormal_ion_homeostasis1.01869337
90MP0002722_abnormal_immune_system1.01609416
91MP0002420_abnormal_adaptive_immunity1.01443566
92MP0002429_abnormal_blood_cell1.01077829
93MP0002019_abnormal_tumor_incidence1.01003558
94MP0009333_abnormal_splenocyte_physiolog1.00432523
95MP0001819_abnormal_immune_cell0.98944160
96MP0002398_abnormal_bone_marrow0.98519700
97MP0003638_abnormal_response/metabolism_0.98508684
98MP0000858_altered_metastatic_potential0.98258001
99MP0003195_calcinosis0.98112544
100MP0008873_increased_physiological_sensi0.96712626
101MP0005084_abnormal_gallbladder_morpholo0.96647173
102MP0005266_abnormal_metabolism0.96635105
103MP0008004_abnormal_stomach_pH0.95964124
104MP0005387_immune_system_phenotype0.95832082
105MP0001790_abnormal_immune_system0.95832082
106MP0002452_abnormal_antigen_presenting0.95327235
107MP0005384_cellular_phenotype0.95284570
108MP0004947_skin_inflammation0.93898462
109MP0010030_abnormal_orbit_morphology0.93511355
110MP0000598_abnormal_liver_morphology0.93484006
111MP0001968_abnormal_touch/_nociception0.93284458
112MP0002837_dystrophic_cardiac_calcinosis0.93233097
113MP0005376_homeostasis/metabolism_phenot0.93124709
114MP0008874_decreased_physiological_sensi0.92384083
115MP0000689_abnormal_spleen_morphology0.91904018
116MP0002136_abnormal_kidney_physiology0.91561002
117MP0003436_decreased_susceptibility_to0.90905226
118MP0001730_embryonic_growth_arrest0.90790576
119MP0001664_abnormal_digestion0.89870528
120MP0003566_abnormal_cell_adhesion0.89799172
121MP0000490_abnormal_crypts_of0.89751592
122MP0000747_muscle_weakness0.89677544
123MP0004782_abnormal_surfactant_physiolog0.88449213
124MP0001853_heart_inflammation0.87338710
125MP0009764_decreased_sensitivity_to0.86808820
126MP0003252_abnormal_bile_duct0.86366104
127MP0000716_abnormal_immune_system0.86293334
128MP0000685_abnormal_immune_system0.85766156
129MP0009642_abnormal_blood_homeostasis0.83964103
130MP0005464_abnormal_platelet_physiology0.82362804
131MP0001905_abnormal_dopamine_level0.81053043
132MP0003693_abnormal_embryo_hatching0.80711612
133MP0000350_abnormal_cell_proliferation0.79719515
134MP0005165_increased_susceptibility_to0.79346721
135MP0005410_abnormal_fertilization0.78548762
136MP0001545_abnormal_hematopoietic_system0.78027613
137MP0005397_hematopoietic_system_phenotyp0.78027613
138MP0005025_abnormal_response_to0.77229701
139MP0005166_decreased_susceptibility_to0.77054744
140MP0005621_abnormal_cell_physiology0.76684200
141MP0005381_digestive/alimentary_phenotyp0.76095909
142MP0001800_abnormal_humoral_immune0.75833665
143MP0000230_abnormal_systemic_arterial0.75430247
144MP0002909_abnormal_adrenal_gland0.75035404
145MP0004957_abnormal_blastocyst_morpholog0.74027472
146MP0001845_abnormal_inflammatory_respons0.73692791
147MP0005535_abnormal_body_temperature0.71181639
148MP0000343_altered_response_to0.70831902
149MP0002138_abnormal_hepatobiliary_system0.69256104
150MP0001970_abnormal_pain_threshold0.68805133
151MP0001529_abnormal_vocalization0.66590881
152MP0000477_abnormal_intestine_morphology0.66520753
153MP0010155_abnormal_intestine_physiology0.64371241
154MP0009765_abnormal_xenobiotic_induced0.63406839

Predicted human phenotypes

RankGene SetZ-score
1Decreased activity of mitochondrial respiratory chain (HP:0008972)4.15402653
2Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.15402653
3Abnormality of aromatic amino acid family metabolism (HP:0004338)3.86726777
4Abnormality of fatty-acid metabolism (HP:0004359)3.64545190
5Hepatic necrosis (HP:0002605)3.56763684
6Microvesicular hepatic steatosis (HP:0001414)3.52069404
7Malnutrition (HP:0004395)3.47248473
8Generalized aminoaciduria (HP:0002909)3.30960059
9Hepatocellular necrosis (HP:0001404)3.24145159
10Abnormality of dicarboxylic acid metabolism (HP:0010995)3.23544870
11Dicarboxylic aciduria (HP:0003215)3.23544870
12Xanthomatosis (HP:0000991)3.13432223
13Gout (HP:0001997)3.09257432
14Ragged-red muscle fibers (HP:0003200)3.01600241
15Abnormal mitochondria in muscle tissue (HP:0008316)3.00062799
16Oligomenorrhea (HP:0000876)2.99991435
17Type I transferrin isoform profile (HP:0003642)2.99670959
18Hyperammonemia (HP:0001987)2.99180759
19Hyperglycinuria (HP:0003108)2.98986811
20Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.95234889
21Hepatosplenomegaly (HP:0001433)2.87064091
22Acute encephalopathy (HP:0006846)2.87031800
23Abnormality of serine family amino acid metabolism (HP:0010894)2.83787563
24Abnormality of glycine metabolism (HP:0010895)2.83787563
25Increased muscle lipid content (HP:0009058)2.77854570
26Abnormality of the anterior horn cell (HP:0006802)2.77455714
27Degeneration of anterior horn cells (HP:0002398)2.77455714
28Abnormality of monocarboxylic acid metabolism (HP:0010996)2.75498578
29Renal Fanconi syndrome (HP:0001994)2.75103605
30Hyperglycinemia (HP:0002154)2.74892578
31Acute necrotizing encephalopathy (HP:0006965)2.73410129
32Mitochondrial inheritance (HP:0001427)2.73378255
33Lethargy (HP:0001254)2.69454773
34Testicular atrophy (HP:0000029)2.69180553
35Purpura (HP:0000979)2.65555148
36Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.63808266
37Abnormal protein N-linked glycosylation (HP:0012347)2.63808266
38Abnormal protein glycosylation (HP:0012346)2.63808266
39Abnormal glycosylation (HP:0012345)2.63808266
40Palpitations (HP:0001962)2.63308983
41Abnormal gallbladder physiology (HP:0012438)2.59968915
42Cholecystitis (HP:0001082)2.59968915
43Lactic acidosis (HP:0003128)2.57313257
44Vacuolated lymphocytes (HP:0001922)2.56855462
45Abnormality of glycolipid metabolism (HP:0010969)2.55042182
46Abnormality of liposaccharide metabolism (HP:0010968)2.55042182
47Abnormality of glycosphingolipid metabolism (HP:0004343)2.55042182
48Hyperlipoproteinemia (HP:0010980)2.53861584
49Abnormality of glutamine family amino acid metabolism (HP:0010902)2.53731002
50Hypoglycemic coma (HP:0001325)2.50480200
51Cerebral edema (HP:0002181)2.50252154
52Ketosis (HP:0001946)2.47305921
53Increased CSF lactate (HP:0002490)2.42911336
54Loss of speech (HP:0002371)2.42538226
55Methylmalonic aciduria (HP:0012120)2.42474909
56Myoglobinuria (HP:0002913)2.40736378
57Increased intramyocellular lipid droplets (HP:0012240)2.40251390
583-Methylglutaconic aciduria (HP:0003535)2.39069008
59Multiple enchondromatosis (HP:0005701)2.38476704
60Spastic paraparesis (HP:0002313)2.38091752
61Nausea (HP:0002018)2.35805290
62Progressive neurologic deterioration (HP:0002344)2.34010631
63Vomiting (HP:0002013)2.32605387
64Rough bone trabeculation (HP:0100670)2.31906598
65Abnormality of purine metabolism (HP:0004352)2.29786413
66Progressive muscle weakness (HP:0003323)2.29512589
67Abnormality of cells of the erythroid lineage (HP:0012130)2.27608050
68Hypokinesia (HP:0002375)2.27571209
69Intrahepatic cholestasis (HP:0001406)2.25884751
70Increased serum lactate (HP:0002151)2.23860521
71Delayed CNS myelination (HP:0002188)2.23692589
72Abnormality of the heme biosynthetic pathway (HP:0010472)2.23551439
73Neuroendocrine neoplasm (HP:0100634)2.22626922
74Emotional lability (HP:0000712)2.21883633
75Irritability (HP:0000737)2.21589551
76Abnormality of the motor neurons (HP:0002450)2.21579212
77Abnormal neuron morphology (HP:0012757)2.21579212
78Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.21463513
79Axonal loss (HP:0003447)2.21323797
80Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.20394382
81Hypobetalipoproteinemia (HP:0003563)2.20282154
82Increased hepatocellular lipid droplets (HP:0006565)2.20196113
83Cerebral palsy (HP:0100021)2.19596682
84Lipid accumulation in hepatocytes (HP:0006561)2.19553318
85Broad distal phalanx of finger (HP:0009836)2.19389157
86Respiratory failure (HP:0002878)2.16739231
87CNS demyelination (HP:0007305)2.15330726
88Brushfield spots (HP:0001088)2.13317242
89Abnormal number of erythroid precursors (HP:0012131)2.12118668
90Proximal tubulopathy (HP:0000114)2.11922468
91Cholelithiasis (HP:0001081)2.11806811
92Microretrognathia (HP:0000308)2.11627038
93Increased purine levels (HP:0004368)2.11457935
94Hyperuricemia (HP:0002149)2.11457935
95Hypertensive crisis (HP:0100735)2.09324189
96Reduced antithrombin III activity (HP:0001976)2.06346895
97Prolonged neonatal jaundice (HP:0006579)2.05819001
98Abnormal gallbladder morphology (HP:0012437)2.05162597
99Atrophy/Degeneration involving motor neurons (HP:0007373)2.05010449
100Increased serum pyruvate (HP:0003542)2.04159752
101Abnormality of glycolysis (HP:0004366)2.04159752
102Hyperbilirubinemia (HP:0002904)2.02737950
103Dysautonomia (HP:0002459)2.02361638
104Abnormal pupillary function (HP:0007686)2.02094104
105Late onset (HP:0003584)2.01234790
106Ketoacidosis (HP:0001993)2.00865283
107Vertebral compression fractures (HP:0002953)2.00463545
108Dry hair (HP:0011359)1.98296135
109Upper limb muscle weakness (HP:0003484)1.97786575
110Opisthotonus (HP:0002179)1.97374154
111Abnormality of the gallbladder (HP:0005264)1.97258162
112Increased IgM level (HP:0003496)1.97172450
113Abnormality of serum amino acid levels (HP:0003112)1.96041518
114Abnormality of nucleobase metabolism (HP:0010932)1.94713860
115Progressive macrocephaly (HP:0004481)1.94627404
116Abnormality of urine glucose concentration (HP:0011016)1.94408653
117Glycosuria (HP:0003076)1.94408653
118Aplastic anemia (HP:0001915)1.93910081
119Hypolipoproteinemia (HP:0010981)1.91995867
120Cerebral hypomyelination (HP:0006808)1.91990013
121Petechiae (HP:0000967)1.91970529
122Pancytopenia (HP:0001876)1.91503332
123Fasciculations (HP:0002380)1.91400867
124Increased serum ferritin (HP:0003281)1.90763816
125Growth hormone excess (HP:0000845)1.90644582
126Metabolic acidosis (HP:0001942)1.90303335
127Death in infancy (HP:0001522)1.90202570
128Abnormality of lateral ventricle (HP:0030047)1.89442866
129Esophageal neoplasm (HP:0100751)1.89436673
130Neoplasm of head and neck (HP:0012288)1.89436673
131Neonatal onset (HP:0003623)1.88349821
132Abnormal cartilage morphology (HP:0002763)1.87432926
133Rhabdomyolysis (HP:0003201)1.87152143
134Deep venous thrombosis (HP:0002625)1.87078460
135Abnormality of transition element cation homeostasis (HP:0011030)1.86605901
136Exercise intolerance (HP:0003546)1.84943771
137Interstitial pulmonary disease (HP:0006530)1.83838092
138Abnormality of macrophages (HP:0004311)1.82819166
139Epiphyseal stippling (HP:0010655)1.82229335
140Progressive microcephaly (HP:0000253)1.81956646
141Abnormality of iron homeostasis (HP:0011031)1.81941969
142Increased cerebral lipofuscin (HP:0011813)1.81862929
143Delusions (HP:0000746)1.81777348
144Secondary amenorrhea (HP:0000869)1.80109193
145Exertional dyspnea (HP:0002875)1.79342272
146Postnatal microcephaly (HP:0005484)1.77660908
147Orthostatic hypotension (HP:0001278)1.77169494
148Panhypogammaglobulinemia (HP:0003139)1.76945430
149Acute hepatic failure (HP:0006554)1.76437449
150Abnormal autonomic nervous system physiology (HP:0012332)1.76123056

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R4.34156559
2VRK23.98538700
3BCKDK3.82943695
4KSR23.63241348
5MAP3K122.92608452
6NME22.90463506
7ARAF2.77910869
8BUB12.73629776
9ERN12.69320000
10MAP3K22.57044774
11TIE12.40960689
12PIK3CA2.32351787
13IRAK32.29962976
14CDK192.23670313
15KDR2.17191309
16PIM22.16066574
17MAP2K22.06856499
18NME12.03845645
19TRIB31.98577028
20MAP4K21.87616853
21TESK11.84888235
22MYLK1.82360358
23LMTK21.76468746
24EIF2AK11.76090658
25MAP2K11.67196197
26MAPKAPK31.63885941
27SRPK11.62357845
28VRK11.61500739
29NEK11.61062900
30MAP3K111.52288647
31TESK21.47546479
32SMG11.46790922
33MET1.43163309
34CSNK1G31.39824752
35CDK81.34925530
36SCYL21.34516730
37STK161.30829458
38LRRK21.28948321
39LIMK11.28042970
40DAPK21.19267036
41RPS6KB21.16919403
42SIK31.15069317
43DAPK31.10830914
44CSNK1A1L1.10769407
45BRAF1.10474049
46TRIM281.09420924
47PAK41.09325599
48ZAK1.08059345
49DAPK11.06772682
50TBK11.05857321
51GRK61.02846977
52MAP3K11.02576864
53WEE11.02449750
54CCNB11.02371414
55CAMKK21.01204098
56MAP3K30.98565740
57PRKG20.98248405
58MAP3K80.94809762
59MATK0.93585699
60PRKD30.92443770
61PDK30.91027614
62PDK40.91027614
63EPHA20.87010791
64ILK0.86677025
65TAOK20.84377423
66EIF2AK30.84107142
67CSNK1G20.82853107
68MAP2K70.82416191
69CSNK1G10.76798271
70EEF2K0.75854093
71FLT30.75241769
72FGFR40.74999899
73TSSK60.74682624
74ZAP700.73706990
75MAP2K60.73065837
76RAF10.72549175
77MAP4K10.71500909
78TGFBR10.71426912
79RPS6KA40.68592495
80RPS6KA50.68140784
81ACVR1B0.67846296
82PAK60.67384467
83PBK0.66294598
84ABL20.63768140
85BRSK10.62780378
86TLK10.60942410
87NTRK10.60509695
88GRK50.59990982
89TEC0.57826067
90CLK10.57232496
91MAPK110.55358927
92PAK10.54537078
93TYK20.53720952
94STK100.53590517
95PIK3CG0.52635129
96BRSK20.51800743
97CDK70.50925053
98IKBKB0.50016656
99PINK10.49464221
100MAP3K50.49410894
101PLK30.47210538
102PRPF4B0.45936540
103AURKA0.44533099
104FES0.44355254
105BMX0.43556642
106PDK20.41494432
107MAP2K30.39605062
108AURKB0.39148151
109ATR0.38711936
110TTK0.38493010
111CDK140.38308506
112PLK10.38144353
113TNK20.37269772
114MOS0.36476544
115BMPR1B0.36306451
116JAK20.36228886
117BTK0.36014228
118AKT20.35915286
119MAPKAPK50.35025658
120STK40.33772791
121CDK11A0.33288498
122MAPKAPK20.32367383
123DYRK20.32102179
124MAP3K90.31904371
125PHKG20.31230945
126PHKG10.31230945
127CAMK2G0.30319310
128CAMK10.30052885
129CDK150.29822053
130OXSR10.29463790
131EIF2AK20.29039019
132PRKCD0.28416886
133ADRBK10.28321431
134EPHB10.27632059
135CDK180.27422584
136PRKCI0.27390268
137RIPK40.27045835
138CAMK2D0.26891957
139KIT0.26387724
140MINK10.26015782
141MST40.23196013
142PDPK10.20528850
143RET0.19881071

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.16416815
2Proteasome_Homo sapiens_hsa030502.99081591
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.82217248
4Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.65370908
5Oxidative phosphorylation_Homo sapiens_hsa001902.45805936
6Folate biosynthesis_Homo sapiens_hsa007902.37767691
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.34139080
8Ribosome_Homo sapiens_hsa030102.21138826
9Parkinsons disease_Homo sapiens_hsa050122.18976553
10Carbon metabolism_Homo sapiens_hsa012002.18827081
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.15177823
12Fatty acid degradation_Homo sapiens_hsa000712.06571335
13Sulfur metabolism_Homo sapiens_hsa009202.02072767
14Pyruvate metabolism_Homo sapiens_hsa006202.00859809
15Pentose phosphate pathway_Homo sapiens_hsa000302.00594069
16Fructose and mannose metabolism_Homo sapiens_hsa000511.99874738
17Propanoate metabolism_Homo sapiens_hsa006401.94273107
18Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.93561090
19Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.92806584
20Drug metabolism - other enzymes_Homo sapiens_hsa009831.92005367
21Biosynthesis of amino acids_Homo sapiens_hsa012301.89536879
22Mismatch repair_Homo sapiens_hsa034301.89088401
23Primary bile acid biosynthesis_Homo sapiens_hsa001201.84154621
24Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.80697850
25Sulfur relay system_Homo sapiens_hsa041221.74843940
26Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.73101715
27Caffeine metabolism_Homo sapiens_hsa002321.65689355
28Tryptophan metabolism_Homo sapiens_hsa003801.64488758
29Peroxisome_Homo sapiens_hsa041461.57319786
30Pentose and glucuronate interconversions_Homo sapiens_hsa000401.49394734
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.45686207
32Spliceosome_Homo sapiens_hsa030401.43919648
33PPAR signaling pathway_Homo sapiens_hsa033201.41698541
34Histidine metabolism_Homo sapiens_hsa003401.40379933
35Alzheimers disease_Homo sapiens_hsa050101.38939919
36Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.38831273
37Glycosaminoglycan degradation_Homo sapiens_hsa005311.37893232
38Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.37483788
39Glutathione metabolism_Homo sapiens_hsa004801.37117407
40Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.36052960
41Galactose metabolism_Homo sapiens_hsa000521.35263705
42Phenylalanine metabolism_Homo sapiens_hsa003601.35052527
43Arginine biosynthesis_Homo sapiens_hsa002201.34683477
44Butanoate metabolism_Homo sapiens_hsa006501.31486418
45Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.30763586
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.30743518
47Cyanoamino acid metabolism_Homo sapiens_hsa004601.30273269
48Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.29978714
49Fatty acid metabolism_Homo sapiens_hsa012121.24381726
50Huntingtons disease_Homo sapiens_hsa050161.24289074
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.20871834
52Bile secretion_Homo sapiens_hsa049761.20544444
53SNARE interactions in vesicular transport_Homo sapiens_hsa041301.18608897
54Chemical carcinogenesis_Homo sapiens_hsa052041.16957340
55Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.15743249
56Nucleotide excision repair_Homo sapiens_hsa034201.13836720
57Nitrogen metabolism_Homo sapiens_hsa009101.13727907
58beta-Alanine metabolism_Homo sapiens_hsa004101.12717161
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.11417389
60Fat digestion and absorption_Homo sapiens_hsa049751.08467908
61Antigen processing and presentation_Homo sapiens_hsa046121.08290507
62Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.07647118
63N-Glycan biosynthesis_Homo sapiens_hsa005101.07616441
64Primary immunodeficiency_Homo sapiens_hsa053401.04700056
65Selenocompound metabolism_Homo sapiens_hsa004501.04290256
66Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.00866685
67Pyrimidine metabolism_Homo sapiens_hsa002401.00746803
68Glycerolipid metabolism_Homo sapiens_hsa005610.98864718
69Regulation of autophagy_Homo sapiens_hsa041400.96868507
70Mineral absorption_Homo sapiens_hsa049780.95676233
71Tyrosine metabolism_Homo sapiens_hsa003500.91074576
72Non-homologous end-joining_Homo sapiens_hsa034500.89274021
73Vitamin B6 metabolism_Homo sapiens_hsa007500.89004799
74Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.88774784
75Thyroid cancer_Homo sapiens_hsa052160.85945694
76Metabolic pathways_Homo sapiens_hsa011000.84572776
77Arginine and proline metabolism_Homo sapiens_hsa003300.83617215
78Fatty acid elongation_Homo sapiens_hsa000620.82526327
79Collecting duct acid secretion_Homo sapiens_hsa049660.80360563
80RNA transport_Homo sapiens_hsa030130.75237911
81Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74899319
82Autoimmune thyroid disease_Homo sapiens_hsa053200.74318039
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.73540353
84Starch and sucrose metabolism_Homo sapiens_hsa005000.73453858
85Epstein-Barr virus infection_Homo sapiens_hsa051690.70430605
86Systemic lupus erythematosus_Homo sapiens_hsa053220.69656790
87Allograft rejection_Homo sapiens_hsa053300.69395095
88Homologous recombination_Homo sapiens_hsa034400.69109362
89RNA polymerase_Homo sapiens_hsa030200.67538635
90Synaptic vesicle cycle_Homo sapiens_hsa047210.67283078
91Vibrio cholerae infection_Homo sapiens_hsa051100.66317662
92One carbon pool by folate_Homo sapiens_hsa006700.65624773
93Rheumatoid arthritis_Homo sapiens_hsa053230.63333938
94Vitamin digestion and absorption_Homo sapiens_hsa049770.62832382
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.62654987
96Steroid biosynthesis_Homo sapiens_hsa001000.59362824
97Other glycan degradation_Homo sapiens_hsa005110.57079082
98Bladder cancer_Homo sapiens_hsa052190.54582383
99Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53958875
100Lysosome_Homo sapiens_hsa041420.53695976
101Salmonella infection_Homo sapiens_hsa051320.53322267
102Retinol metabolism_Homo sapiens_hsa008300.52442351
103Complement and coagulation cascades_Homo sapiens_hsa046100.52013806
104Legionellosis_Homo sapiens_hsa051340.50870359
105Phagosome_Homo sapiens_hsa041450.46027000
106Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.45350426
107Glycerophospholipid metabolism_Homo sapiens_hsa005640.45288217
108Herpes simplex infection_Homo sapiens_hsa051680.45279892
109Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.45123350
110Cell cycle_Homo sapiens_hsa041100.44965785
111DNA replication_Homo sapiens_hsa030300.43799801
112Viral myocarditis_Homo sapiens_hsa054160.43043970
113Graft-versus-host disease_Homo sapiens_hsa053320.42969904
114ABC transporters_Homo sapiens_hsa020100.40111093
115RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.39345885
116Base excision repair_Homo sapiens_hsa034100.38918131
117Adipocytokine signaling pathway_Homo sapiens_hsa049200.38504445
118Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38466752
119Alcoholism_Homo sapiens_hsa050340.38114073
120Purine metabolism_Homo sapiens_hsa002300.37732975
121Cardiac muscle contraction_Homo sapiens_hsa042600.36483691
122Type I diabetes mellitus_Homo sapiens_hsa049400.35320771
123Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.34812344
124Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.34799685
125Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.34546044
126Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.34199486
127Apoptosis_Homo sapiens_hsa042100.34053019
128Pertussis_Homo sapiens_hsa051330.32272211
129Viral carcinogenesis_Homo sapiens_hsa052030.30049131
130Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.29915569
131Shigellosis_Homo sapiens_hsa051310.29131871
132Protein export_Homo sapiens_hsa030600.27220457
133Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.25409776
134Prion diseases_Homo sapiens_hsa050200.24818772
135Maturity onset diabetes of the young_Homo sapiens_hsa049500.20740223
136Central carbon metabolism in cancer_Homo sapiens_hsa052300.19202802
137Renin-angiotensin system_Homo sapiens_hsa046140.15156570

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