PECAM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1short-term memory (GO:0007614)9.02773210
2presynaptic membrane assembly (GO:0097105)5.49237093
3positive regulation of gamma-delta T cell activation (GO:0046645)5.07624280
4postsynaptic membrane organization (GO:0001941)5.05954985
5negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)4.87973983
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.86185850
7regulation of pigment cell differentiation (GO:0050932)4.82774813
8negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.68486911
9negative regulation of cell killing (GO:0031342)4.68486911
10presynaptic membrane organization (GO:0097090)4.59325250
11modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.54634159
12positive regulation by organism of defense response of other organism involved in symbiotic interact4.54634159
13modulation by symbiont of host immune response (GO:0052553)4.54634159
14positive regulation by symbiont of host defense response (GO:0052509)4.54634159
15modulation by symbiont of host defense response (GO:0052031)4.54634159
16modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.54634159
17positive regulation of dendritic spine morphogenesis (GO:0061003)4.40996666
18neutrophil activation involved in immune response (GO:0002283)4.37467611
19detection of other organism (GO:0098543)4.19822095
20positive regulation of protein kinase C signaling (GO:0090037)4.18639841
21antigen processing and presentation of endogenous antigen (GO:0019883)4.15631618
22central nervous system myelination (GO:0022010)4.15192880
23axon ensheathment in central nervous system (GO:0032291)4.15192880
24regulation of protein kinase C signaling (GO:0090036)4.14237506
25neuronal action potential propagation (GO:0019227)4.14133384
26response to folic acid (GO:0051593)4.11684182
27antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.02808420
28positive regulation of dendritic spine development (GO:0060999)4.02623867
29cellular extravasation (GO:0045123)3.99863015
30lymph vessel development (GO:0001945)3.97753695
31macrophage activation involved in immune response (GO:0002281)3.91959673
32negative regulation of interleukin-12 production (GO:0032695)3.89288433
33positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.88865518
34regulation of B cell receptor signaling pathway (GO:0050855)3.88371160
35response to peptidoglycan (GO:0032494)3.82179927
36negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)3.79019297
37detection of bacterium (GO:0016045)3.77355303
38regulation of gamma-delta T cell activation (GO:0046643)3.76186077
39metanephric tubule development (GO:0072170)3.75988378
40metanephric nephron tubule development (GO:0072234)3.75988378
41pattern specification involved in kidney development (GO:0061004)3.75000569
42angiogenesis involved in wound healing (GO:0060055)3.74445989
43detection of molecule of bacterial origin (GO:0032490)3.73252944
44negative regulation of myotube differentiation (GO:0010832)3.72783182
45negative regulation of execution phase of apoptosis (GO:1900118)3.70257639
46positive regulation of synapse assembly (GO:0051965)3.69201843
47macrophage activation (GO:0042116)3.65102308
48facial nerve structural organization (GO:0021612)3.63034173
49metanephric nephron epithelium development (GO:0072243)3.62338982
50detection of external biotic stimulus (GO:0098581)3.62226133
51amino sugar catabolic process (GO:0046348)3.59303943
52DNA ligation (GO:0006266)3.57407628
53negative regulation of transcription by competitive promoter binding (GO:0010944)3.55473760
54antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.52919945
55regulation of gamma-delta T cell differentiation (GO:0045586)3.47324106
56morphogenesis of an endothelium (GO:0003159)3.46616594
57endothelial tube morphogenesis (GO:0061154)3.46616594
58omega-hydroxylase P450 pathway (GO:0097267)3.45962940
59metanephric epithelium development (GO:0072207)3.41363175
60positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.34747271
61negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.33596444
62regulation of interferon-beta biosynthetic process (GO:0045357)3.32055784
63neutrophil activation (GO:0042119)3.31221697
64microglial cell activation (GO:0001774)3.30181816
65negative regulation of erythrocyte differentiation (GO:0045647)3.29232935
66positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.28016404
67developmental pigmentation (GO:0048066)3.27069670
68cranial nerve morphogenesis (GO:0021602)3.26272250
69viral transcription (GO:0019083)3.26206089
70immunoglobulin mediated immune response (GO:0016064)3.23466813
71peptidyl-threonine dephosphorylation (GO:0035970)3.21390744
72negative regulation of blood vessel endothelial cell migration (GO:0043537)3.21059338
73regulation of dendritic cell antigen processing and presentation (GO:0002604)3.18278949
74response to host immune response (GO:0052572)3.18033937
75response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.18033937
76detection of biotic stimulus (GO:0009595)3.17810276
77glucosamine-containing compound catabolic process (GO:1901072)3.17427306
78negative regulation of Ras GTPase activity (GO:0034261)3.17418943
79neuron remodeling (GO:0016322)3.17357716
80limb bud formation (GO:0060174)3.16259991
81lymphangiogenesis (GO:0001946)3.14212478
82translational termination (GO:0006415)3.13756382
83regulation of tolerance induction (GO:0002643)3.13423982
84cranial nerve structural organization (GO:0021604)3.13261821
85regulation of mast cell degranulation (GO:0043304)3.12975459
86regulation of T cell tolerance induction (GO:0002664)3.12859704
87negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.11843747
88eyelid development in camera-type eye (GO:0061029)3.11656214
89leukocyte migration involved in inflammatory response (GO:0002523)3.10860229
90retina vasculature morphogenesis in camera-type eye (GO:0061299)3.08944204
91positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.08052976
92positive regulation of amino acid transport (GO:0051957)3.07716654
93regulation of fibroblast growth factor receptor signaling pathway (GO:0040036)3.06651796
94negative regulation of lymphocyte mediated immunity (GO:0002707)3.04326907
95granulocyte activation (GO:0036230)3.03644657
96regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.03615119
97myeloid cell activation involved in immune response (GO:0002275)3.03045589
98positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)3.01552300
99negative regulation of synaptic transmission, GABAergic (GO:0032229)2.99827046
100positive regulation of tolerance induction (GO:0002645)2.98064991
101blood vessel maturation (GO:0001955)2.96780992
102vocalization behavior (GO:0071625)2.96305408
103response to muramyl dipeptide (GO:0032495)2.96192003
104positive regulation of mast cell activation (GO:0033005)2.96053871
105positive regulation of B cell differentiation (GO:0045579)2.95195700
106protein heterotetramerization (GO:0051290)2.94123953
107response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.93281078
108response to host (GO:0075136)2.93281078
109response to host defenses (GO:0052200)2.93281078
110positive regulation of protein autophosphorylation (GO:0031954)2.91891950
111regulation of mast cell activation involved in immune response (GO:0033006)2.91766456
112organ growth (GO:0035265)2.91720792
113membrane assembly (GO:0071709)2.90240601
114ribosomal small subunit biogenesis (GO:0042274)2.89508383
115positive thymic T cell selection (GO:0045059)2.88421281
116regulation of myeloid leukocyte mediated immunity (GO:0002886)2.88187389
117regulation of dendritic spine development (GO:0060998)2.88078502
118regulation of leukocyte degranulation (GO:0043300)2.85989024
119cotranslational protein targeting to membrane (GO:0006613)2.85342841
120germinal center formation (GO:0002467)2.85288100
121regulation of mast cell activation (GO:0033003)2.85176328
122antigen processing and presentation via MHC class Ib (GO:0002475)2.84474179
123B cell receptor signaling pathway (GO:0050853)2.84052369
124GTP biosynthetic process (GO:0006183)2.83935797
125regulation of cardiac muscle cell contraction (GO:0086004)2.83796608
126GMP metabolic process (GO:0046037)2.83133367
127negative regulation of T cell mediated immunity (GO:0002710)2.82784767
128neuron cell-cell adhesion (GO:0007158)2.81824657
129negative regulation of leukocyte mediated immunity (GO:0002704)2.81731599
130protein targeting to ER (GO:0045047)2.81329389
131response to interleukin-15 (GO:0070672)2.79648088
132respiratory burst (GO:0045730)2.77451187
133neutrophil mediated immunity (GO:0002446)2.77274142
134regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.77240630
135regulation of axon extension involved in axon guidance (GO:0048841)2.77143775
136negative regulation of nitric-oxide synthase activity (GO:0051001)2.76045423
137negative regulation of granulocyte differentiation (GO:0030853)2.75458662
138SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.75432279
139lipopolysaccharide-mediated signaling pathway (GO:0031663)2.75135013
140regulation of non-canonical Wnt signaling pathway (GO:2000050)2.74353944
141leukocyte aggregation (GO:0070486)2.73392863
142positive regulation of vasculogenesis (GO:2001214)2.73198664
143regulation of synapse assembly (GO:0051963)2.72518339
144mesonephros development (GO:0001823)2.72141576
145establishment of protein localization to endoplasmic reticulum (GO:0072599)2.71411309
146positive regulation of metanephros development (GO:0072216)2.70670037
147production of molecular mediator involved in inflammatory response (GO:0002532)2.70333186
148myeloid leukocyte activation (GO:0002274)2.70188798
149regulation of antigen processing and presentation (GO:0002577)2.69768882
150regulation of T-helper 2 cell differentiation (GO:0045628)2.68820229
151negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.66795430
152negative regulation of T-helper cell differentiation (GO:0045623)2.66795430
153import into cell (GO:0098657)2.65507397
154branch elongation of an epithelium (GO:0060602)2.64825389
155regulation of macrophage cytokine production (GO:0010935)2.63982987
156ventricular system development (GO:0021591)2.63642233
157righting reflex (GO:0060013)2.62936091
158epithelial cilium movement (GO:0003351)2.62756837
159Rap protein signal transduction (GO:0032486)2.62247062
160embryonic body morphogenesis (GO:0010172)2.61902109
161sprouting angiogenesis (GO:0002040)2.61306910
162glomerular basement membrane development (GO:0032836)2.59624184
163* endothelium development (GO:0003158)2.59017352
164lateral sprouting from an epithelium (GO:0060601)2.58779264
165negative regulation of DNA-dependent DNA replication (GO:2000104)2.58597796
166positive regulation of cellular amine metabolic process (GO:0033240)2.58566101
167positive regulation of mast cell degranulation (GO:0043306)2.58528353
168positive regulation of mast cell activation involved in immune response (GO:0033008)2.58528353
169positive regulation of receptor recycling (GO:0001921)2.57009138
170regulation of axon guidance (GO:1902667)2.56555542
171protein localization to endoplasmic reticulum (GO:0070972)2.56522851
172centriole replication (GO:0007099)2.56237966
173regulation of B cell differentiation (GO:0045577)2.55907034
174positive regulation of systemic arterial blood pressure (GO:0003084)2.54409583
175interferon-gamma-mediated signaling pathway (GO:0060333)2.54012568
176negative regulation of cytokine production involved in immune response (GO:0002719)2.53360748
177regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.52905821
178regulation of protein kinase A signaling (GO:0010738)2.52863858
179amino acid import (GO:0043090)2.50477274
180positive regulation of odontogenesis (GO:0042482)2.49674224
181cellular response to interleukin-15 (GO:0071350)2.48653892
182leukocyte degranulation (GO:0043299)2.48268681
183sphingoid metabolic process (GO:0046519)2.47389860
184T-helper 1 type immune response (GO:0042088)2.46929088
185cilium movement (GO:0003341)2.46548220
186neutrophil chemotaxis (GO:0030593)2.46296721
187vascular endothelial growth factor signaling pathway (GO:0038084)2.45777298
188response to increased oxygen levels (GO:0036296)2.45672352
189response to hyperoxia (GO:0055093)2.45672352
190* nephron epithelium development (GO:0072009)2.45131842
191forebrain neuron development (GO:0021884)2.44881736
192positive regulation of type 2 immune response (GO:0002830)2.44867354
193positive regulation of antigen processing and presentation (GO:0002579)2.44811368
194regulation of smooth muscle cell differentiation (GO:0051150)2.44779820
195regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.44683649
196mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.43004068

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.06563928
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.60010294
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.62509653
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.41644295
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.39348964
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.34269098
7GBX2_23144817_ChIP-Seq_PC3_Human3.31472810
8JARID2_20064375_ChIP-Seq_MESCs_Mouse3.20226873
9GATA2_21666600_ChIP-Seq_HMVEC_Human3.16087282
10* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.15261635
11IRF8_27001747_Chip-Seq_BMDM_Mouse3.02204674
12* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.99418457
13TAF15_26573619_Chip-Seq_HEK293_Human2.97835790
14TRIM28_21343339_ChIP-Seq_HEK293_Human2.85177981
15RUNX_20019798_ChIP-Seq_JUKART_Human2.67072771
16SCL_19346495_ChIP-Seq_HPC-7_Human2.61908499
17* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.59162026
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.58991548
19SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.58892512
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.54209804
21* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.50528577
22SPI1_23127762_ChIP-Seq_K562_Human2.47464776
23EED_16625203_ChIP-ChIP_MESCs_Mouse2.46742230
24SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.43735918
25EZH2_18974828_ChIP-Seq_MESCs_Mouse2.39259855
26RNF2_18974828_ChIP-Seq_MESCs_Mouse2.39259855
27IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.39189708
28STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.31944453
29AR_21572438_ChIP-Seq_LNCaP_Human2.31163350
30SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.30923293
31SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.30386407
32Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.26422698
33RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.25316114
34SMAD_19615063_ChIP-ChIP_OVARY_Human2.24938529
35SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.24273486
36JARID2_20075857_ChIP-Seq_MESCs_Mouse2.18546860
37KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.15714229
38KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.15714229
39KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.15714229
40NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.10732477
41CBX2_27304074_Chip-Seq_ESCs_Mouse2.10414206
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.10359918
43PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.09083718
44VDR_24763502_ChIP-Seq_THP-1_Human2.05981497
45IGF1R_20145208_ChIP-Seq_DFB_Human2.01850121
46HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.98152019
47* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.96696671
48KDM2B_26808549_Chip-Seq_SUP-B15_Human1.95814388
49* SPI1_23547873_ChIP-Seq_NB4_Human1.95673897
50ZFP57_27257070_Chip-Seq_ESCs_Mouse1.93656368
51WT1_19549856_ChIP-ChIP_CCG9911_Human1.92596632
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.92480628
53FLI1_27457419_Chip-Seq_LIVER_Mouse1.90393431
54VDR_24787735_ChIP-Seq_THP-1_Human1.89032587
55PCGF2_27294783_Chip-Seq_ESCs_Mouse1.87498971
56BP1_19119308_ChIP-ChIP_Hs578T_Human1.85904311
57PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.85381193
58VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.84713627
59NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.83482201
60CDX2_19796622_ChIP-Seq_MESCs_Mouse1.82506673
61BMI1_23680149_ChIP-Seq_NPCS_Mouse1.81266008
62* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.79431012
63* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.79355773
64VDR_21846776_ChIP-Seq_THP-1_Human1.75147080
65SUZ12_27294783_Chip-Seq_ESCs_Mouse1.75116974
66RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.74594382
67* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.74344575
68ELK3_25401928_ChIP-Seq_HUVEC_Human1.73553044
69RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.73507947
70MTF2_20144788_ChIP-Seq_MESCs_Mouse1.73060104
71LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.72577150
72RUNX1_22412390_ChIP-Seq_EML_Mouse1.71536727
73* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.70499030
74EZH2_27294783_Chip-Seq_ESCs_Mouse1.70313998
75LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.70114242
76RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.69066128
77E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.68018617
78MYB_26560356_Chip-Seq_TH2_Human1.65200501
79POU3F2_20337985_ChIP-ChIP_501MEL_Human1.64747700
80* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.64488108
81MAF_26560356_Chip-Seq_TH1_Human1.63434329
82GATA1_19941827_ChIP-Seq_MEL_Mouse1.62085133
83RNF2_27304074_Chip-Seq_ESCs_Mouse1.58304039
84PIAS1_25552417_ChIP-Seq_VCAP_Human1.57276842
85GATA1_19941826_ChIP-Seq_K562_Human1.55670974
86TCF7_22412390_ChIP-Seq_EML_Mouse1.54860308
87SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.54683059
88MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.53378558
89IKZF1_21737484_ChIP-ChIP_HCT116_Human1.53046482
90CTBP2_25329375_ChIP-Seq_LNCAP_Human1.52388455
91ER_23166858_ChIP-Seq_MCF-7_Human1.50675749
92TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49309129
93SMAD3_21741376_ChIP-Seq_EPCs_Human1.47379646
94GATA1_22025678_ChIP-Seq_K562_Human1.47215816
95* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.46571239
96GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.45717498
97UTX_26944678_Chip-Seq_JUKART_Human1.45429281
98TP53_18474530_ChIP-ChIP_U2OS_Human1.45263283
99P300_19829295_ChIP-Seq_ESCs_Human1.45095610
100SUZ12_27294783_Chip-Seq_NPCs_Mouse1.42192482
101MYB_26560356_Chip-Seq_TH1_Human1.40993049
102PCGF2_27294783_Chip-Seq_NPCs_Mouse1.38303971
103* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.37480561
104EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.37443816
105THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.36624918
106DROSHA_22980978_ChIP-Seq_HELA_Human1.36152834
107NFE2_27457419_Chip-Seq_LIVER_Mouse1.34992242
108SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34779653
109TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.34687258
110EZH2_27294783_Chip-Seq_NPCs_Mouse1.33251345
111CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32438030
112FUS_26573619_Chip-Seq_HEK293_Human1.32225158
113NANOG_18555785_Chip-Seq_ESCs_Mouse1.32069170
114* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.31961876
115EGR1_19374776_ChIP-ChIP_THP-1_Human1.29775243
116OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29616630
117* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.28195265
118KDM2B_26808549_Chip-Seq_DND41_Human1.28025647
119PU_27001747_Chip-Seq_BMDM_Mouse1.27831110
120E2F1_18555785_Chip-Seq_ESCs_Mouse1.26148533
121GATA3_27048872_Chip-Seq_THYMUS_Human1.25198938
122TP53_16413492_ChIP-PET_HCT116_Human1.25193469
123CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.24700805
124SMAD4_21799915_ChIP-Seq_A2780_Human1.24406658
125VDR_22108803_ChIP-Seq_LS180_Human1.24177571
126P300_18555785_Chip-Seq_ESCs_Mouse1.23811139
127KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.23807758
128ZNF274_21170338_ChIP-Seq_K562_Hela1.23671916
129GATA2_22383799_ChIP-Seq_G1ME_Mouse1.22003707
130P53_22387025_ChIP-Seq_ESCs_Mouse1.20407688
131TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.20344955
132POU5F1_16153702_ChIP-ChIP_HESCs_Human1.17104839
133ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.17009830
134EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.14942362
135STAT6_21828071_ChIP-Seq_BEAS2B_Human1.13647056
136GATA2_19941826_ChIP-Seq_K562_Human1.13614540
137TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13234041
138* RUNX2_22187159_ChIP-Seq_PCA_Human1.12916635
139SUZ12_18555785_Chip-Seq_ESCs_Mouse1.12406917
140* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12254309
141RUNX1_27457419_Chip-Seq_LIVER_Mouse1.12119389
142* RNF2_27304074_Chip-Seq_NSC_Mouse1.09050778
143UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07844539
144NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.06423754
145RING1B_27294783_Chip-Seq_ESCs_Mouse1.06244404
146RING1B_27294783_Chip-Seq_NPCs_Mouse1.05982461
147CMYC_18555785_Chip-Seq_ESCs_Mouse1.05814386
148SMAD3_21741376_ChIP-Seq_HESCs_Human1.04061704
149NMYC_18555785_Chip-Seq_ESCs_Mouse1.03771795
150SOX2_18555785_Chip-Seq_ESCs_Mouse1.03568063
151MAF_26560356_Chip-Seq_TH2_Human1.02950293
152GATA1_22383799_ChIP-Seq_G1ME_Mouse1.02242213
153STAT3_18555785_Chip-Seq_ESCs_Mouse1.02181322
154OCT4_18555785_Chip-Seq_ESCs_Mouse1.01260304
155TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.00242971
156GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99678322
157NOTCH1_21737748_ChIP-Seq_TLL_Human0.99521987
158CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.99501107
159SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99432116
160* EP300_21415370_ChIP-Seq_HL-1_Mouse0.98457261
161CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98149638
162LXR_22292898_ChIP-Seq_THP-1_Human0.98011411
163FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.97555048
164KDM2B_26808549_Chip-Seq_REH_Human0.97397619
165STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.95915504
166SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.95138449
167ZNF217_24962896_ChIP-Seq_MCF-7_Human0.95014167
168GATA1_19941827_ChIP-Seq_MEL86_Mouse0.94997460
169GATA3_26560356_Chip-Seq_TH2_Human0.94835796
170* TBX20_22328084_ChIP-Seq_HEART_Mouse0.94531492
171* TBX20_22080862_ChIP-Seq_HEART_Mouse0.94531492
172VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.94085659
173MYC_22102868_ChIP-Seq_BL_Human0.93867840
174KDM2B_26808549_Chip-Seq_JURKAT_Human0.92919627
175KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.92861984
176* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92430766
177* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91888343
178PRDM14_20953172_ChIP-Seq_ESCs_Human0.91769701
179ZFX_18555785_Chip-Seq_ESCs_Mouse0.91136492
180* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89540719
181CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.87550667
182RARG_19884340_ChIP-ChIP_MEFs_Mouse0.85987621
183SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85402421
184RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.78892150
185CTCF_27219007_Chip-Seq_ERYTHROID_Human0.74945408
186LXR_22158963_ChIP-Seq_LIVER_Mouse0.74492220
187FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.74174698
188* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.73246278
189SPI1_20517297_ChIP-Seq_HL60_Human0.72913211
190ESR2_21235772_ChIP-Seq_MCF-7_Human0.72872261
191STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.72562924
192SALL4_18804426_ChIP-ChIP_XEN_Mouse0.72389386
193BCL6_27268052_Chip-Seq_Bcells_Human0.72228213

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation8.80748517
2MP0005409_darkened_coat_color5.30538797
3MP0001188_hyperpigmentation5.05237053
4MP0003136_yellow_coat_color4.73262166
5MP0003880_abnormal_central_pattern3.27608084
6MP0003436_decreased_susceptibility_to3.08054234
7* MP0003303_peritoneal_inflammation3.07358471
8MP0001835_abnormal_antigen_presentation2.89534173
9MP0010368_abnormal_lymphatic_system2.78696800
10MP0004272_abnormal_basement_membrane2.76143749
11MP0001879_abnormal_lymphatic_vessel2.74623400
12MP0002419_abnormal_innate_immunity2.59609257
13MP0002102_abnormal_ear_morphology2.54826365
14MP0004381_abnormal_hair_follicle2.51117052
15MP0003300_gastrointestinal_ulcer2.48794825
16MP0003191_abnormal_cellular_cholesterol2.43052341
17MP0006082_CNS_inflammation2.28840593
18MP0000015_abnormal_ear_pigmentation2.28543753
19MP0005025_abnormal_response_to2.26479276
20MP0005174_abnormal_tail_pigmentation2.24099323
21MP0005464_abnormal_platelet_physiology2.23522211
22MP0005671_abnormal_response_to2.20677922
23MP0009785_altered_susceptibility_to2.20474419
24MP0001790_abnormal_immune_system2.16002976
25MP0005387_immune_system_phenotype2.16002976
26MP0002138_abnormal_hepatobiliary_system2.14629158
27* MP0005000_abnormal_immune_tolerance2.13212048
28MP0001800_abnormal_humoral_immune2.09758712
29MP0000685_abnormal_immune_system2.06955964
30MP0002452_abnormal_antigen_presenting1.96960225
31MP0006292_abnormal_olfactory_placode1.93510896
32* MP0002420_abnormal_adaptive_immunity1.93216086
33MP0001986_abnormal_taste_sensitivity1.92546640
34MP0002148_abnormal_hypersensitivity_rea1.91507398
35* MP0001819_abnormal_immune_cell1.91468630
36* MP0002723_abnormal_immune_serum1.91081723
37* MP0003724_increased_susceptibility_to1.82136090
38* MP0001533_abnormal_skeleton_physiology1.78105067
39MP0005058_abnormal_lysosome_morphology1.77036938
40MP0003172_abnormal_lysosome_physiology1.75031791
41MP0010155_abnormal_intestine_physiology1.67688676
42MP0003941_abnormal_skin_development1.67261013
43MP0002405_respiratory_system_inflammati1.66416385
44MP0009764_decreased_sensitivity_to1.63620963
45MP0002177_abnormal_outer_ear1.54477640
46MP0000343_altered_response_to1.52977635
47MP0003279_aneurysm1.50640663
48MP0003075_altered_response_to1.50039438
49MP0009278_abnormal_bone_marrow1.49421384
50MP0000049_abnormal_middle_ear1.47724838
51MP0009250_abnormal_appendicular_skeleto1.45791875
52MP0006054_spinal_hemorrhage1.45441251
53MP0004742_abnormal_vestibular_system1.44512411
54MP0003763_abnormal_thymus_physiology1.44394902
55MP0003938_abnormal_ear_development1.43280887
56* MP0005595_abnormal_vascular_smooth1.40859480
57MP0000716_abnormal_immune_system1.39304731
58MP0002398_abnormal_bone_marrow1.36097820
59MP0004883_abnormal_blood_vessel1.34548941
60* MP0000249_abnormal_blood_vessel1.33888339
61* MP0001845_abnormal_inflammatory_respons1.33362404
62MP0002998_abnormal_bone_remodeling1.33141050
63MP0004510_myositis1.32008944
64MP0003385_abnormal_body_wall1.31481200
65MP0004947_skin_inflammation1.31446492
66MP0006276_abnormal_autonomic_nervous1.31351473
67MP0002249_abnormal_larynx_morphology1.26885053
68MP0004142_abnormal_muscle_tone1.26439287
69MP0002332_abnormal_exercise_endurance1.26342452
70MP0005397_hematopoietic_system_phenotyp1.25289543
71MP0001545_abnormal_hematopoietic_system1.25289543
72MP0005451_abnormal_body_composition1.22789914
73MP0000920_abnormal_myelination1.22508329
74MP0000751_myopathy1.21877050
75MP0003690_abnormal_glial_cell1.21459422
76MP0005166_decreased_susceptibility_to1.18651927
77MP0002095_abnormal_skin_pigmentation1.17911154
78MP0005666_abnormal_adipose_tissue1.17552169
79MP0005165_increased_susceptibility_to1.16185426
80MP0008438_abnormal_cutaneous_collagen1.16082109
81MP0001958_emphysema1.15817538
82MP0001486_abnormal_startle_reflex1.14844959
83MP0002429_abnormal_blood_cell1.14524523
84MP0005171_absent_coat_pigmentation1.13612360
85* MP0000689_abnormal_spleen_morphology1.12910161
86MP0008469_abnormal_protein_level1.12899131
87MP0002722_abnormal_immune_system1.12674320
88MP0003866_abnormal_defecation1.11606438
89MP0002166_altered_tumor_susceptibility1.10393042
90MP0001968_abnormal_touch/_nociception1.08402275
91MP0000858_altered_metastatic_potential1.07704151
92MP0004185_abnormal_adipocyte_glucose1.05384713
93MP0009745_abnormal_behavioral_response1.04124831
94MP0008260_abnormal_autophagy1.03901887
95MP0006138_congestive_heart_failure1.03606483
96MP0000778_abnormal_nervous_system1.03426719
97MP0003868_abnormal_feces_composition1.03137863
98MP0002132_abnormal_respiratory_system1.02766280
99MP0005623_abnormal_meninges_morphology1.02547345
100MP0003448_altered_tumor_morphology1.01148276
101MP0000465_gastrointestinal_hemorrhage1.00553310
102MP0004145_abnormal_muscle_electrophysio1.00390418
103MP0003566_abnormal_cell_adhesion0.99030389
104MP0003937_abnormal_limbs/digits/tail_de0.98242024
105MP0000026_abnormal_inner_ear0.97336686
106MP0005310_abnormal_salivary_gland0.94212969
107MP0002067_abnormal_sensory_capabilities0.93495471
108MP0009333_abnormal_splenocyte_physiolog0.92501718
109MP0003183_abnormal_peptide_metabolism0.92233354
110MP0003635_abnormal_synaptic_transmissio0.91719940
111MP0003045_fibrosis0.91005388
112MP0001915_intracranial_hemorrhage0.90957741
113MP0003646_muscle_fatigue0.90494178
114MP0000613_abnormal_salivary_gland0.89919864
115MP0002272_abnormal_nervous_system0.89663796
116* MP0002933_joint_inflammation0.88784533
117MP0001853_heart_inflammation0.88057972
118MP0001346_abnormal_lacrimal_gland0.87971839
119MP0004130_abnormal_muscle_cell0.86782668
120MP0000631_abnormal_neuroendocrine_gland0.86006599
121MP0005084_abnormal_gallbladder_morpholo0.83775904
122MP0001727_abnormal_embryo_implantation0.83198288
123MP0000762_abnormal_tongue_morphology0.82900408
124MP0000467_abnormal_esophagus_morphology0.82297634
125MP0001919_abnormal_reproductive_system0.81420873
126MP0004808_abnormal_hematopoietic_stem0.81381311
127MP0000372_irregular_coat_pigmentation0.80644358
128MP0000703_abnormal_thymus_morphology0.80368429
129MP0001970_abnormal_pain_threshold0.78990068
130MP0002277_abnormal_respiratory_mucosa0.78712362
131MP0002877_abnormal_melanocyte_morpholog0.78034743
132MP0002064_seizures0.77315062
133MP0002751_abnormal_autonomic_nervous0.77242268
134MP0000604_amyloidosis0.77205074
135* MP0001614_abnormal_blood_vessel0.76083918
136MP0005257_abnormal_intraocular_pressure0.76062504
137MP0000681_abnormal_thyroid_gland0.74823874
138MP0009840_abnormal_foam_cell0.74324319
139MP0003705_abnormal_hypodermis_morpholog0.74136730
140MP0001905_abnormal_dopamine_level0.73841893
141MP0002127_abnormal_cardiovascular_syste0.73589275
142MP0004084_abnormal_cardiac_muscle0.72946565
143MP0009763_increased_sensitivity_to0.72827829
144* MP0005390_skeleton_phenotype0.72473173
145MP0000767_abnormal_smooth_muscle0.72035142
146MP0005423_abnormal_somatic_nervous0.71980647
147MP0003315_abnormal_perineum_morphology0.71933594
148MP0001851_eye_inflammation0.71591625
149MP0009046_muscle_twitch0.71559856
150MP0001542_abnormal_bone_strength0.69230238
151MP0004133_heterotaxia0.68970250
152MP0002752_abnormal_somatic_nervous0.68108730
153MP0001661_extended_life_span0.67716794
154MP0005385_cardiovascular_system_phenoty0.67357932
155MP0001544_abnormal_cardiovascular_syste0.67357932
156MP0000749_muscle_degeneration0.67053641
157MP0005379_endocrine/exocrine_gland_phen0.66870180
158* MP0003828_pulmonary_edema0.66857356
159MP0002876_abnormal_thyroid_physiology0.66855871
160MP0005167_abnormal_blood-brain_barrier0.66414534
161MP0004484_altered_response_of0.66357146
162MP0002557_abnormal_social/conspecific_i0.65598565
163MP0002160_abnormal_reproductive_system0.64724678
164MP0008004_abnormal_stomach_pH0.64061360
165MP0001440_abnormal_grooming_behavior0.63637754
166MP0004147_increased_porphyrin_level0.62482396
167MP0005164_abnormal_response_to0.62281166
168MP0005551_abnormal_eye_electrophysiolog0.61315064
169MP0003755_abnormal_palate_morphology0.60635979
170MP0003091_abnormal_cell_migration0.60331898
171MP0008932_abnormal_embryonic_tissue0.60272566
172MP0002734_abnormal_mechanical_nocicepti0.59681778
173MP0005375_adipose_tissue_phenotype0.58339669
174MP0002572_abnormal_emotion/affect_behav0.57276221
175MP0002735_abnormal_chemical_nociception0.56861073
176* MP0002133_abnormal_respiratory_system0.56781460
177* MP0005388_respiratory_system_phenotype0.56781460
178MP0001963_abnormal_hearing_physiology0.56524244
179MP0002971_abnormal_brown_adipose0.56488961
180MP0004085_abnormal_heartbeat0.56176707
181MP0002282_abnormal_trachea_morphology0.54765687

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.22551969
2Recurrent abscess formation (HP:0002722)4.77234208
3Myositis (HP:0100614)4.61304533
4Obstructive sleep apnea (HP:0002870)4.58532978
5Recurrent bacterial skin infections (HP:0005406)4.55277705
6Abnormality of macrophages (HP:0004311)4.34320962
7Hematochezia (HP:0002573)4.34174022
8Orchitis (HP:0100796)4.33284402
9Concave nail (HP:0001598)4.07897388
10Recurrent gram-negative bacterial infections (HP:0005420)4.06421029
11Optic neuritis (HP:0100653)4.04306093
12Retrobulbar optic neuritis (HP:0100654)4.04306093
13Premature rupture of membranes (HP:0001788)3.95654739
14Reduced antithrombin III activity (HP:0001976)3.76426805
15Elevated erythrocyte sedimentation rate (HP:0003565)3.76409974
16Prolonged bleeding time (HP:0003010)3.72852687
17Polycythemia (HP:0001901)3.57644284
18Abnormality of secondary sexual hair (HP:0009888)3.54167131
19Abnormality of the axillary hair (HP:0100134)3.54167131
20Aplasia/Hypoplasia of the sacrum (HP:0008517)3.52709245
21Thyroid-stimulating hormone excess (HP:0002925)3.52323143
22Epistaxis (HP:0000421)3.34438101
23Abnormality of liposaccharide metabolism (HP:0010968)3.26920345
24Abnormality of glycosphingolipid metabolism (HP:0004343)3.26920345
25Abnormality of glycolipid metabolism (HP:0010969)3.26920345
26Hemoptysis (HP:0002105)3.23539742
27Sex reversal (HP:0012245)3.18821161
28Abnormal sex determination (HP:0012244)3.18821161
29Recurrent fungal infections (HP:0002841)3.14167502
30Keratoconjunctivitis sicca (HP:0001097)3.05951688
31Mediastinal lymphadenopathy (HP:0100721)3.05825259
32Type I transferrin isoform profile (HP:0003642)3.03789102
33Abnormality of the vasculature of the conjunctiva (HP:0008054)2.98710206
34Recurrent skin infections (HP:0001581)2.97262857
35Conjunctival telangiectasia (HP:0000524)2.96235773
36Gastrointestinal infarctions (HP:0005244)2.95238602
37Amyloidosis (HP:0011034)2.94105997
38Meningitis (HP:0001287)2.92211204
39Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.86579631
40Gingivitis (HP:0000230)2.86533874
41Chest pain (HP:0100749)2.86434913
42Pulmonary embolism (HP:0002204)2.84325095
43Congenital, generalized hypertrichosis (HP:0004540)2.84091053
44Keratoconjunctivitis (HP:0001096)2.82204105
45Esophageal varix (HP:0002040)2.80706568
46Congenital sensorineural hearing impairment (HP:0008527)2.80513777
47Increased cerebral lipofuscin (HP:0011813)2.79341190
48Attenuation of retinal blood vessels (HP:0007843)2.78201134
49Submucous cleft hard palate (HP:0000176)2.77281537
50Upper limb muscle weakness (HP:0003484)2.74779010
51Testicular atrophy (HP:0000029)2.72851202
52Pulmonary infiltrates (HP:0002113)2.72675565
53Vasculitis (HP:0002633)2.72122147
54Cellulitis (HP:0100658)2.71552188
55Increased IgE level (HP:0003212)2.70415346
56Obstructive lung disease (HP:0006536)2.68976697
57Chronic obstructive pulmonary disease (HP:0006510)2.68976697
58Dysostosis multiplex (HP:0000943)2.68125348
59Abnormal delayed hypersensitivity skin test (HP:0002963)2.67783852
60Arterial thrombosis (HP:0004420)2.67609440
61Seborrheic dermatitis (HP:0001051)2.66978361
62Gingival bleeding (HP:0000225)2.66829689
63Cerebral hemorrhage (HP:0001342)2.64472573
64Cerebral aneurysm (HP:0004944)2.63989307
65Abnormality of the nasal mucosa (HP:0000433)2.62662916
66Sleep apnea (HP:0010535)2.62187242
67Encephalitis (HP:0002383)2.59805042
68Chin dimple (HP:0010751)2.59399553
69Split foot (HP:0001839)2.57222058
70Recurrent cutaneous fungal infections (HP:0011370)2.56490964
71Chronic mucocutaneous candidiasis (HP:0002728)2.56490964
72T lymphocytopenia (HP:0005403)2.50260832
73Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.48906389
74Steppage gait (HP:0003376)2.47061419
75Abnormal ciliary motility (HP:0012262)2.46340582
76Abnormality of T cell number (HP:0011839)2.45576450
77Urticaria (HP:0001025)2.42635583
78Petechiae (HP:0000967)2.42171626
79Purpura (HP:0000979)2.41164644
80Flat occiput (HP:0005469)2.39560338
81Hemiplegia (HP:0002301)2.39256645
82Leukocytosis (HP:0001974)2.38929151
83Sparse lateral eyebrow (HP:0005338)2.37298907
84Autoimmune thrombocytopenia (HP:0001973)2.36658971
85Peripheral hypomyelination (HP:0007182)2.36055069
86Dynein arm defect of respiratory motile cilia (HP:0012255)2.34889777
87Absent/shortened dynein arms (HP:0200106)2.34889777
88Capillary hemangiomas (HP:0005306)2.34343648
89Aplasia cutis congenita (HP:0001057)2.33526615
90Hyperthyroidism (HP:0000836)2.33189623
91Aplasia involving bones of the upper limbs (HP:0009823)2.32218625
92Aplasia of the phalanges of the hand (HP:0009802)2.32218625
93Aplasia involving bones of the extremities (HP:0009825)2.32218625
94Increased hepatocellular lipid droplets (HP:0006565)2.32028118
95Systemic lupus erythematosus (HP:0002725)2.31720497
96Ulnar claw (HP:0001178)2.29475910
97Myocardial infarction (HP:0001658)2.28970028
98Abnormality of dental color (HP:0011073)2.27901344
99Episodic fever (HP:0001954)2.27148301
100Increased neuronal autofluorescent lipopigment (HP:0002074)2.27136529
101Osteomyelitis (HP:0002754)2.26197778
102Parakeratosis (HP:0001036)2.26171774
103Peritonitis (HP:0002586)2.23880047
104Abnormal platelet volume (HP:0011876)2.22646652
105Overfolded helix (HP:0000396)2.22399126
106Vertigo (HP:0002321)2.20995700
107Abnormality of polysaccharide metabolism (HP:0011012)2.19754247
108Abnormality of glycosaminoglycan metabolism (HP:0004371)2.19754247
109Abnormality of mucopolysaccharide metabolism (HP:0011020)2.19754247
110Reticulocytopenia (HP:0001896)2.19387128
111Stomatitis (HP:0010280)2.19342339
112Mitral regurgitation (HP:0001653)2.18261913
113Impaired platelet aggregation (HP:0003540)2.18115435
114Abnormal platelet function (HP:0011869)2.18115435
115Abnormal pupillary function (HP:0007686)2.16897416
116Nonprogressive disorder (HP:0003680)2.16356768
117Sensory axonal neuropathy (HP:0003390)2.16266636
118Mucosal telangiectasiae (HP:0100579)2.16064456
119Hemorrhage of the eye (HP:0011885)2.15435342
120Inflammation of the large intestine (HP:0002037)2.15157603
121Abnormal respiratory epithelium morphology (HP:0012253)2.15097771
122Abnormal respiratory motile cilium morphology (HP:0005938)2.15097771
123Portal hypertension (HP:0001409)2.14416798
124Tracheomalacia (HP:0002779)2.13952985
125Recurrent viral infections (HP:0004429)2.13479544
126Mucopolysacchariduria (HP:0008155)2.13412278
127Urinary glycosaminoglycan excretion (HP:0003541)2.13412278
128Difficulty running (HP:0009046)2.12435633
129Vacuolated lymphocytes (HP:0001922)2.12200080
130Abnormality of the peritoneum (HP:0002585)2.11968245
131Abnormality of magnesium homeostasis (HP:0004921)2.11567426
132Distal lower limb amyotrophy (HP:0008944)2.10982725
133Thrombophlebitis (HP:0004418)2.10906407
134Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.10414138
135Atelectasis (HP:0100750)2.10293455
136Exertional dyspnea (HP:0002875)2.10055386
137Microcytic anemia (HP:0001935)2.08359455
138Nasolacrimal duct obstruction (HP:0000579)2.07217581
139Absent rod-and cone-mediated responses on ERG (HP:0007688)2.06976053
140Focal motor seizures (HP:0011153)2.06526419
141Abnormality of the pleura (HP:0002103)2.06434826
142Muscle fiber splitting (HP:0003555)2.05305174
143Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.05062079
144Spontaneous hematomas (HP:0007420)2.03292965
145Hypoparathyroidism (HP:0000829)2.02727443
146Loss of speech (HP:0002371)2.02327560
147Optic disc pallor (HP:0000543)2.01619598
148Gastrointestinal inflammation (HP:0004386)2.01487529
149Interstitial pulmonary disease (HP:0006530)2.01087866
150Pulmonary artery stenosis (HP:0004415)1.99797131
151Macrocytic anemia (HP:0001972)1.98894434
152Hypophosphatemic rickets (HP:0004912)1.98078953
153Renal Fanconi syndrome (HP:0001994)1.97996686
154Increased CSF protein (HP:0002922)1.96867423
155Colitis (HP:0002583)1.95533917
156Supernumerary spleens (HP:0009799)1.93813695
157Abnormal respiratory motile cilium physiology (HP:0012261)1.93039999
158Joint hemorrhage (HP:0005261)1.92740278
159Abnormality of T cells (HP:0002843)1.92718240
160Severe visual impairment (HP:0001141)1.92020549
161Abnormality of the hepatic vasculature (HP:0006707)1.90954898
162Venous insufficiency (HP:0005293)1.90929786
163Asymmetric septal hypertrophy (HP:0001670)1.90618134
164Granulocytopenia (HP:0001913)1.89843424
165Cerebral ischemia (HP:0002637)1.89660397
166Abnormal hemoglobin (HP:0011902)1.89430059
167Hypertensive crisis (HP:0100735)1.89150722
168Prolonged partial thromboplastin time (HP:0003645)1.89065205
169Absent speech (HP:0001344)1.88205662
170Progressive external ophthalmoplegia (HP:0000590)1.88127758
171Porencephaly (HP:0002132)1.87931837
172Ocular albinism (HP:0001107)1.87648661
173Abnormal large intestine physiology (HP:0012700)1.85509119
174Abnormality of the columella (HP:0009929)1.84714655
175Abnormally folded helix (HP:0008544)1.84591498
176Morphological abnormality of the middle ear (HP:0008609)1.84226975
177Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.83722613
178Abnormal protein N-linked glycosylation (HP:0012347)1.83722613
179Abnormal protein glycosylation (HP:0012346)1.83722613
180Abnormal glycosylation (HP:0012345)1.83722613
181Synostosis involving the elbow (HP:0003938)1.82765337
182Humeroradial synostosis (HP:0003041)1.82765337
183Bowel incontinence (HP:0002607)1.81542599
184Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.81151340
185Abnormality of the tricuspid valve (HP:0001702)1.80843310
186Annular pancreas (HP:0001734)1.80037633
187Hypothermia (HP:0002045)1.78468226
188Hypomagnesemia (HP:0002917)1.78179949
189Menorrhagia (HP:0000132)1.77223553
190Microvesicular hepatic steatosis (HP:0001414)1.76235595
191Venous abnormality (HP:0002624)1.72964379
192Bradycardia (HP:0001662)1.71473445
193Lipid accumulation in hepatocytes (HP:0006561)1.70721008

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MKNK25.67131251
2CASK5.27721935
3TNIK5.22084907
4TLK13.98054229
5TIE13.11563498
6EIF2AK33.10822640
7BLK3.10041259
8MKNK13.09462170
9MAP4K12.67929473
10MAP2K32.49216736
11NLK2.24088069
12TYK22.09840910
13* CSK2.02679334
14ERN11.97615325
15STK161.95174293
16ZAP701.92646094
17DMPK1.88349092
18PRPF4B1.87900480
19JAK31.73276769
20EIF2AK21.68161048
21STK391.60974263
22BTK1.56418644
23KDR1.54950217
24MAP3K31.52515844
25MAP3K141.50090453
26MAP3K111.47455511
27CLK11.41442163
28IRAK11.38486775
29SYK1.36352680
30MAP3K131.33537004
31ITK1.29263410
32* HCK1.28923749
33KIT1.28067695
34GRK61.26766094
35MUSK1.26440612
36TEC1.25235045
37TXK1.24302739
38IRAK41.24255922
39NME21.22113973
40TNK21.16981293
41PRKD21.15115712
42CAMK11.15064698
43JAK11.13002978
44TBK11.12166308
45IRAK31.12128845
46FGR1.11809660
47PKN11.10391365
48MAP2K71.09411429
49CAMKK21.06465664
50TAOK31.05978435
51MATK1.05340866
52SRPK11.04486931
53PRKAA21.01033126
54CAMK2B1.01000728
55CSF1R1.00575732
56* LYN1.00261868
57PNCK1.00015102
58MAPK150.99927734
59GRK10.99468121
60YES10.98401993
61JAK20.97647067
62IKBKE0.96601000
63TAOK10.96477132
64CDK190.95428067
65TGFBR20.91759293
66OXSR10.91754063
67EIF2AK10.89890072
68MAPK130.89801207
69PIK3CG0.89199175
70IRAK20.86804071
71CDK90.85172957
72TGFBR10.84017025
73PIM20.82018283
74GRK70.81081867
75UHMK10.81009452
76PTK2B0.75648703
77NTRK30.75272280
78STK100.73974875
79RIPK10.72179746
80NUAK10.70915348
81PHKG10.69349526
82PHKG20.69349526
83CAMK2D0.67792026
84STK110.67219972
85MAPK70.67142687
86BMPR1B0.67054164
87KSR20.66530320
88PDPK10.66334048
89MARK20.65783035
90PDK10.65359304
91MAPK40.64209437
92PTK60.63873832
93HIPK20.63451730
94PRKG20.63399735
95CAMK2A0.63073179
96TRPM70.62661688
97MAPKAPK50.61521670
98IKBKB0.61471447
99TTN0.61392647
100DYRK1A0.61134817
101MOS0.59281429
102BMPR20.58432011
103ADRBK10.58346530
104MAP3K60.58022102
105FGFR30.57644091
106* FES0.55539577
107EPHA30.55432412
108EPHB20.55196870
109BUB10.54684205
110MAP3K70.54578951
111MINK10.53502358
112CDC42BPA0.52293785
113PAK20.52186769
114LRRK20.51954011
115INSRR0.50682270
116ADRBK20.49206367
117MARK30.48722977
118TAOK20.47868051
119PRKG10.47041665
120WNK40.46675175
121SGK30.46230806
122FGFR40.45658832
123PDGFRB0.44511134
124RPS6KA50.42569932
125* FYN0.42527498
126WNK10.41187046
127CDK80.41154178
128CSNK1G10.40987461
129DAPK30.40755005
130SGK20.40012924
131EGFR0.38572043
132ROCK20.37899071
133PRKD10.37661311
134CDK30.37442244
135MAPK120.37309430
136PRKCE0.37024327
137EPHB10.36849670
138RPS6KA20.36828603
139IGF1R0.36796807
140GRK50.35376324
141SIK30.34895434
142RIPK40.33520490
143ACVR1B0.33425239
144PRKCQ0.33288678
145TRIB30.33286991
146RET0.32967337
147CDK70.31387492
148* LCK0.31282579
149RPS6KC10.30949963
150RPS6KL10.30949963
151DYRK20.30536574
152CSNK1A1L0.30073116
153SIK20.29535657
154DAPK20.29354206
155MAP3K20.28641167
156MAP3K10.28578198
157VRK10.28343205
158MAPKAPK30.27691155
159CAMK40.27516321
160EPHA40.27466025
161NEK90.26520880
162TESK20.26512139
163CAMK2G0.26253537
164PRKACA0.26191742
165CDK140.24570249
166CSNK2A20.24453942
167ABL10.24442102
168NME10.24311215

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.23041439
2Protein export_Homo sapiens_hsa030602.86436441
3Leishmaniasis_Homo sapiens_hsa051402.74017286
4Staphylococcus aureus infection_Homo sapiens_hsa051502.69846862
5Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.27226507
6Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.17507952
7Nicotine addiction_Homo sapiens_hsa050332.17349896
8Allograft rejection_Homo sapiens_hsa053302.15772130
9Long-term depression_Homo sapiens_hsa047302.12470209
10Graft-versus-host disease_Homo sapiens_hsa053322.12127484
11Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.11097859
12Phototransduction_Homo sapiens_hsa047442.10524888
13Autoimmune thyroid disease_Homo sapiens_hsa053202.00055399
14Tuberculosis_Homo sapiens_hsa051521.90001283
15Glycosaminoglycan degradation_Homo sapiens_hsa005311.88806822
16Axon guidance_Homo sapiens_hsa043601.84451816
17Sphingolipid metabolism_Homo sapiens_hsa006001.80154180
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.78759654
19* Malaria_Homo sapiens_hsa051441.73448656
20Homologous recombination_Homo sapiens_hsa034401.72457113
21Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.71301885
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.66820658
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.63586298
24Toxoplasmosis_Homo sapiens_hsa051451.63151342
25Fanconi anemia pathway_Homo sapiens_hsa034601.57576333
26Asthma_Homo sapiens_hsa053101.56883524
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.54271774
28* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.52806164
29Intestinal immune network for IgA production_Homo sapiens_hsa046721.48973038
30Type I diabetes mellitus_Homo sapiens_hsa049401.48483583
31Viral myocarditis_Homo sapiens_hsa054161.44822218
32Chemokine signaling pathway_Homo sapiens_hsa040621.44112755
33Morphine addiction_Homo sapiens_hsa050321.42683036
34Serotonergic synapse_Homo sapiens_hsa047261.42476566
35Antigen processing and presentation_Homo sapiens_hsa046121.42304741
36Taste transduction_Homo sapiens_hsa047421.40200460
37Rheumatoid arthritis_Homo sapiens_hsa053231.39310462
38Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.38177124
39Phagosome_Homo sapiens_hsa041451.37657460
40Glutamatergic synapse_Homo sapiens_hsa047241.35203599
41Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.35139543
42ECM-receptor interaction_Homo sapiens_hsa045121.34608832
43NF-kappa B signaling pathway_Homo sapiens_hsa040641.33878224
44Pertussis_Homo sapiens_hsa051331.32072409
45Acute myeloid leukemia_Homo sapiens_hsa052211.31623181
46Other glycan degradation_Homo sapiens_hsa005111.31011203
47Oxidative phosphorylation_Homo sapiens_hsa001901.30925504
48Lysosome_Homo sapiens_hsa041421.27247775
49Measles_Homo sapiens_hsa051621.25668316
50Influenza A_Homo sapiens_hsa051641.22553199
51Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.21867424
52T cell receptor signaling pathway_Homo sapiens_hsa046601.21515580
53Calcium signaling pathway_Homo sapiens_hsa040201.21300258
54TNF signaling pathway_Homo sapiens_hsa046681.20322822
55Ether lipid metabolism_Homo sapiens_hsa005651.19489826
56Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.19471332
57Legionellosis_Homo sapiens_hsa051341.16880190
58Hematopoietic cell lineage_Homo sapiens_hsa046401.14072394
59Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.12724598
60Jak-STAT signaling pathway_Homo sapiens_hsa046301.12019336
61Wnt signaling pathway_Homo sapiens_hsa043101.11040574
62Aldosterone synthesis and secretion_Homo sapiens_hsa049251.11000334
63VEGF signaling pathway_Homo sapiens_hsa043701.07889574
64Renin secretion_Homo sapiens_hsa049241.06109399
65Vascular smooth muscle contraction_Homo sapiens_hsa042701.03796258
66Ras signaling pathway_Homo sapiens_hsa040141.02759731
67Amoebiasis_Homo sapiens_hsa051461.02621591
68Fatty acid elongation_Homo sapiens_hsa000621.02126226
69Basal transcription factors_Homo sapiens_hsa030221.00696163
70Notch signaling pathway_Homo sapiens_hsa043301.00017651
71GABAergic synapse_Homo sapiens_hsa047270.97550087
72Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.97301420
73Pancreatic cancer_Homo sapiens_hsa052120.97215982
74Salmonella infection_Homo sapiens_hsa051320.94789131
75HIF-1 signaling pathway_Homo sapiens_hsa040660.93436080
76Melanogenesis_Homo sapiens_hsa049160.92368116
77Alzheimers disease_Homo sapiens_hsa050100.92318385
78Arachidonic acid metabolism_Homo sapiens_hsa005900.91376924
79Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.90913803
80cAMP signaling pathway_Homo sapiens_hsa040240.90578790
81Cardiac muscle contraction_Homo sapiens_hsa042600.90541569
82Hepatitis B_Homo sapiens_hsa051610.88966970
83Melanoma_Homo sapiens_hsa052180.88604210
84Herpes simplex infection_Homo sapiens_hsa051680.87935990
85Shigellosis_Homo sapiens_hsa051310.87624777
86Chronic myeloid leukemia_Homo sapiens_hsa052200.86542472
87Long-term potentiation_Homo sapiens_hsa047200.85480383
88Complement and coagulation cascades_Homo sapiens_hsa046100.85102735
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.84082753
90AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.83686525
91Salivary secretion_Homo sapiens_hsa049700.83481855
92Regulation of actin cytoskeleton_Homo sapiens_hsa048100.82684925
93Gap junction_Homo sapiens_hsa045400.81854090
94Thyroid cancer_Homo sapiens_hsa052160.81643773
95Hepatitis C_Homo sapiens_hsa051600.81507894
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.81431489
97Sulfur relay system_Homo sapiens_hsa041220.81335941
98Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.81207474
99GnRH signaling pathway_Homo sapiens_hsa049120.81058566
100African trypanosomiasis_Homo sapiens_hsa051430.79937604
101Endocytosis_Homo sapiens_hsa041440.79338418
102Apoptosis_Homo sapiens_hsa042100.78373055
103Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.76819526
104Platelet activation_Homo sapiens_hsa046110.75946327
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.75935185
106Transcriptional misregulation in cancer_Homo sapiens_hsa052020.74345338
107Circadian entrainment_Homo sapiens_hsa047130.74331487
108Neurotrophin signaling pathway_Homo sapiens_hsa047220.73983633
109Non-small cell lung cancer_Homo sapiens_hsa052230.73595147
110Oxytocin signaling pathway_Homo sapiens_hsa049210.73364204
111PI3K-Akt signaling pathway_Homo sapiens_hsa041510.73097530
112Dilated cardiomyopathy_Homo sapiens_hsa054140.72626098
113Amphetamine addiction_Homo sapiens_hsa050310.70634213
114Rap1 signaling pathway_Homo sapiens_hsa040150.70579863
115DNA replication_Homo sapiens_hsa030300.70198489
116Primary immunodeficiency_Homo sapiens_hsa053400.69271700
117Cholinergic synapse_Homo sapiens_hsa047250.66590614
118Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.66178842
119Parkinsons disease_Homo sapiens_hsa050120.66075796
120SNARE interactions in vesicular transport_Homo sapiens_hsa041300.65659342
121ErbB signaling pathway_Homo sapiens_hsa040120.64965033
122Focal adhesion_Homo sapiens_hsa045100.64778543
123Prolactin signaling pathway_Homo sapiens_hsa049170.64383082
124RNA polymerase_Homo sapiens_hsa030200.64206815
125Dopaminergic synapse_Homo sapiens_hsa047280.63223185
126Renal cell carcinoma_Homo sapiens_hsa052110.62242211
127Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.62225304
128Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.62035400
129Renin-angiotensin system_Homo sapiens_hsa046140.61688727
130Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.60931816
131Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.60555979
132B cell receptor signaling pathway_Homo sapiens_hsa046620.58876817
133Adipocytokine signaling pathway_Homo sapiens_hsa049200.58167748
134Huntingtons disease_Homo sapiens_hsa050160.57752153
135Osteoclast differentiation_Homo sapiens_hsa043800.57672175
136Pathways in cancer_Homo sapiens_hsa052000.57588626
137RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.57549789
138Dorso-ventral axis formation_Homo sapiens_hsa043200.56499607
139FoxO signaling pathway_Homo sapiens_hsa040680.56010369
140Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.54596448
141Insulin resistance_Homo sapiens_hsa049310.54162171
142MAPK signaling pathway_Homo sapiens_hsa040100.53722437
143Ovarian steroidogenesis_Homo sapiens_hsa049130.52364952
144Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52107760
145Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.51850993
146Circadian rhythm_Homo sapiens_hsa047100.50954251
147TGF-beta signaling pathway_Homo sapiens_hsa043500.50372552
148Prostate cancer_Homo sapiens_hsa052150.49256801
149Choline metabolism in cancer_Homo sapiens_hsa052310.49128769
150Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48987042
151Protein digestion and absorption_Homo sapiens_hsa049740.48521599
152Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48398332
153Tight junction_Homo sapiens_hsa045300.47304187
154Non-homologous end-joining_Homo sapiens_hsa034500.47141096
155Pancreatic secretion_Homo sapiens_hsa049720.47048225
156Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.46885341
157Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45778206
158Gastric acid secretion_Homo sapiens_hsa049710.45741913
159Basal cell carcinoma_Homo sapiens_hsa052170.43699294
160* Leukocyte transendothelial migration_Homo sapiens_hsa046700.43676895
161HTLV-I infection_Homo sapiens_hsa051660.41878315
162Carbohydrate digestion and absorption_Homo sapiens_hsa049730.41842247
163Small cell lung cancer_Homo sapiens_hsa052220.41640063
164MicroRNAs in cancer_Homo sapiens_hsa052060.41474230
165Glycerophospholipid metabolism_Homo sapiens_hsa005640.41182570
166Inositol phosphate metabolism_Homo sapiens_hsa005620.40954999
167mTOR signaling pathway_Homo sapiens_hsa041500.39263640
168Estrogen signaling pathway_Homo sapiens_hsa049150.39114358
169Adherens junction_Homo sapiens_hsa045200.36914802

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