PEAK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a non-receptor tyrosine kinase that is a member of the new kinase family three (NFK3) family. In migrating cells, the encoded protein is associated with the actin cytoskeleton and focal adhesions and promotes developing focal adhesion elongation. This protein may play a role in the regulation of cell migration, proliferation and cancer metastasis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell adhesion mediated by integrin (GO:0033627)4.22478351
2glomerular visceral epithelial cell development (GO:0072015)3.82532013
3chondrocyte proliferation (GO:0035988)3.69909762
4neuron projection extension involved in neuron projection guidance (GO:1902284)3.65565811
5axon extension involved in axon guidance (GO:0048846)3.65565811
6regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.56079903
7regulation of integrin activation (GO:0033623)3.51273915
8interkinetic nuclear migration (GO:0022027)3.50501843
9fibroblast migration (GO:0010761)3.50395144
10growth hormone receptor signaling pathway (GO:0060396)3.47643065
11membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.43072324
12vascular endothelial growth factor signaling pathway (GO:0038084)3.32306189
13glomerular epithelial cell development (GO:0072310)3.23593062
14plasma membrane repair (GO:0001778)3.19059489
15apoptotic cell clearance (GO:0043277)3.16661150
16regulation of hippo signaling (GO:0035330)3.14523495
17positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.14182027
18substrate-dependent cell migration (GO:0006929)3.10020839
19endodermal cell differentiation (GO:0035987)3.09254280
20regulation of pigment cell differentiation (GO:0050932)3.07639284
21regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.06938415
22negative regulation of protein localization to cell surface (GO:2000009)3.02281582
23cytoplasmic mRNA processing body assembly (GO:0033962)3.02200951
24regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.02130254
25cellular response to growth hormone stimulus (GO:0071378)2.98121730
26regulation of axon extension involved in axon guidance (GO:0048841)2.95336778
27collagen fibril organization (GO:0030199)2.94577041
28dermatan sulfate biosynthetic process (GO:0030208)2.88885552
29regulation of establishment of cell polarity (GO:2000114)2.87357873
30synaptic vesicle docking involved in exocytosis (GO:0016081)2.86943076
31negative regulation of axon extension involved in axon guidance (GO:0048843)2.85686776
32positive regulation of developmental pigmentation (GO:0048087)2.84056653
33lipid translocation (GO:0034204)2.83740892
34phospholipid translocation (GO:0045332)2.83740892
35regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.82568832
36hippo signaling (GO:0035329)2.79781785
37basement membrane organization (GO:0071711)2.77041521
38myofibril assembly (GO:0030239)2.73086521
39regulation of axon guidance (GO:1902667)2.69429266
40retina vasculature morphogenesis in camera-type eye (GO:0061299)2.69398610
41regulation of macrophage chemotaxis (GO:0010758)2.69232858
42regulation of tight junction assembly (GO:2000810)2.68951864
43neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.67976223
44regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.67341330
45dermatan sulfate metabolic process (GO:0030205)2.66328580
46cell-substrate junction assembly (GO:0007044)2.66223681
47membrane depolarization during action potential (GO:0086010)2.65997714
48sequestering of extracellular ligand from receptor (GO:0035581)2.65995267
49protein localization to endosome (GO:0036010)2.65621035
50antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.65570335
51behavioral response to nicotine (GO:0035095)2.65247093
52cell migration involved in sprouting angiogenesis (GO:0002042)2.65023575
53negative regulation of translation, ncRNA-mediated (GO:0040033)2.64747695
54regulation of translation, ncRNA-mediated (GO:0045974)2.64747695
55negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.64747695
56nucleus localization (GO:0051647)2.64531151
57stress fiber assembly (GO:0043149)2.64225048
58regulation of establishment or maintenance of cell polarity (GO:0032878)2.63709312
59NLS-bearing protein import into nucleus (GO:0006607)2.63642494
60blood vessel maturation (GO:0001955)2.62872798
61appendage development (GO:0048736)2.61130309
62limb development (GO:0060173)2.61130309
63face morphogenesis (GO:0060325)2.61015481
64* substrate adhesion-dependent cell spreading (GO:0034446)2.58949874
65negative regulation of fatty acid transport (GO:2000192)2.58733534
66snRNA transcription (GO:0009301)2.57773679
67establishment of protein localization to Golgi (GO:0072600)2.57675739
68negative regulation of activin receptor signaling pathway (GO:0032926)2.57507332
69nerve growth factor signaling pathway (GO:0038180)2.53627240
70endocardial cushion development (GO:0003197)2.52832543
71insulin-like growth factor receptor signaling pathway (GO:0048009)2.51328452
72platelet-derived growth factor receptor signaling pathway (GO:0048008)2.51093551
73neuron maturation (GO:0042551)2.49362092
74positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.49136867
75positive regulation of p38MAPK cascade (GO:1900745)2.48928648
76negative regulation of axon guidance (GO:1902668)2.47402440
77paraxial mesoderm development (GO:0048339)2.46842398
78positive regulation of epithelial to mesenchymal transition (GO:0010718)2.46584347
79cardiac myofibril assembly (GO:0055003)2.45846320
80regulation of mitotic spindle organization (GO:0060236)2.45809084
81urinary tract smooth muscle contraction (GO:0014848)2.45683716
82nuclear pore complex assembly (GO:0051292)2.45503604
83tyrosine phosphorylation of STAT protein (GO:0007260)2.44478405
84regulation of short-term neuronal synaptic plasticity (GO:0048172)2.43455116
85regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.43104851
86cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.41945852
87pathway-restricted SMAD protein phosphorylation (GO:0060389)2.41199270
88protein heterotrimerization (GO:0070208)2.41067953
89adherens junction assembly (GO:0034333)2.40530952
90negative regulation of smooth muscle cell migration (GO:0014912)2.40415094
91monoubiquitinated protein deubiquitination (GO:0035520)2.40148483
92cilium or flagellum-dependent cell motility (GO:0001539)2.38788982
93skin morphogenesis (GO:0043589)2.37213492
94regulation of macrophage cytokine production (GO:0010935)2.35014481
95mesodermal cell differentiation (GO:0048333)2.34691976
96wound healing, spreading of epidermal cells (GO:0035313)2.34627494
97epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.32717099
98regulation of sarcomere organization (GO:0060297)2.32432047
99negative regulation of systemic arterial blood pressure (GO:0003085)2.31961429
100corticosteroid receptor signaling pathway (GO:0031958)2.31542909
101response to fluid shear stress (GO:0034405)2.31486799
102cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.31030046
103negative regulation of cytosolic calcium ion concentration (GO:0051481)2.30694582
104pericardium development (GO:0060039)2.30418458
105positive regulation of fibroblast migration (GO:0010763)2.29498474
106positive regulation of endothelial cell apoptotic process (GO:2000353)2.28951821
107regulation of clathrin-mediated endocytosis (GO:2000369)2.28680686
108protein K48-linked deubiquitination (GO:0071108)2.27917561
109negative regulation of granulocyte differentiation (GO:0030853)2.26609280
110negative chemotaxis (GO:0050919)2.26187880
111regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.25834579
112lymphangiogenesis (GO:0001946)2.25612111
113artery development (GO:0060840)2.25309731
114regulation of posttranscriptional gene silencing (GO:0060147)2.24220944
115regulation of gene silencing by miRNA (GO:0060964)2.24220944
116regulation of gene silencing by RNA (GO:0060966)2.24220944
117cellular response to interferon-alpha (GO:0035457)2.23939905
118regulation of SMAD protein import into nucleus (GO:0060390)2.22716491
119wound healing, spreading of cells (GO:0044319)2.21708074
120negative regulation of Rho protein signal transduction (GO:0035024)2.21039000
121positive regulation of SMAD protein import into nucleus (GO:0060391)2.19834707
122smooth muscle tissue development (GO:0048745)2.19740311
123kynurenine metabolic process (GO:0070189)2.19304985
124positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)2.18542363
125focal adhesion assembly (GO:0048041)2.18370263
126cell-substrate adherens junction assembly (GO:0007045)2.18370263
127indole-containing compound catabolic process (GO:0042436)2.18184631
128indolalkylamine catabolic process (GO:0046218)2.18184631
129tryptophan catabolic process (GO:0006569)2.18184631
130positive regulation of phosphatase activity (GO:0010922)2.17620119
131regulation of cardioblast differentiation (GO:0051890)2.17546336
132regulation of transforming growth factor beta2 production (GO:0032909)2.16249286
133blood vessel endothelial cell migration (GO:0043534)2.15855095
134protein localization to cell surface (GO:0034394)2.15463157
135neuron remodeling (GO:0016322)2.14718060
136inner ear receptor cell development (GO:0060119)2.14324924
137cerebellar Purkinje cell differentiation (GO:0021702)2.13975392
138cortical actin cytoskeleton organization (GO:0030866)2.13479298
139atrial cardiac muscle cell action potential (GO:0086014)2.12798923
140mitotic cytokinesis (GO:0000281)2.12658522
141renal tubule morphogenesis (GO:0061333)2.12571464
142cartilage morphogenesis (GO:0060536)2.12120364
143glomerular basement membrane development (GO:0032836)2.11691417
144cAMP biosynthetic process (GO:0006171)2.11644929
145bone trabecula formation (GO:0060346)2.10939725
146central nervous system myelination (GO:0022010)2.10932145
147axon ensheathment in central nervous system (GO:0032291)2.10932145
148mitotic sister chromatid cohesion (GO:0007064)2.10852217
149heart morphogenesis (GO:0003007)2.10643963
150central nervous system projection neuron axonogenesis (GO:0021952)2.10214761
151protein hydroxylation (GO:0018126)2.09916819
152SMAD protein signal transduction (GO:0060395)2.09694789
153gamma-aminobutyric acid transport (GO:0015812)2.08884226
154glucocorticoid receptor signaling pathway (GO:0042921)2.08725574
155mRNA transcription (GO:0009299)2.08559646
156cell-matrix adhesion (GO:0007160)2.08161679
157cAMP metabolic process (GO:0046058)2.07974518
158regulation of early endosome to late endosome transport (GO:2000641)2.07631178
159regulation of p38MAPK cascade (GO:1900744)2.07587007
160regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.07545417
161central nervous system neuron axonogenesis (GO:0021955)2.07531196
162cAMP catabolic process (GO:0006198)2.07276235
163smooth muscle contraction (GO:0006939)2.06987204
164positive regulation of cardiac muscle cell differentiation (GO:2000727)2.06816712
165cyclic nucleotide catabolic process (GO:0009214)2.06424363
166nephron epithelium morphogenesis (GO:0072088)2.05866286
167nephron tubule morphogenesis (GO:0072078)2.05866286
168notochord development (GO:0030903)2.05376098
169mesenchymal-epithelial cell signaling (GO:0060638)2.05250218
170endothelial cell morphogenesis (GO:0001886)2.05246664
171extracellular matrix assembly (GO:0085029)2.05085628
172regulation of mononuclear cell migration (GO:0071675)2.04752411
173negative regulation of sodium ion transport (GO:0010766)2.03466626
174ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.02294304
175negative regulation of leukocyte chemotaxis (GO:0002689)2.02243701
176neural tube formation (GO:0001841)2.02047145
177postsynaptic membrane organization (GO:0001941)2.00785658
178detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)1.99695315
179metanephric mesenchyme development (GO:0072075)1.99065901
180regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO1.96621441
181startle response (GO:0001964)1.95684015
182establishment of nucleus localization (GO:0040023)1.93764720

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.87698968
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.84387157
3SMAD_19615063_ChIP-ChIP_OVARY_Human3.22441848
4GBX2_23144817_ChIP-Seq_PC3_Human3.01667594
5TRIM28_21343339_ChIP-Seq_HEK293_Human2.65859506
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.64438922
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.58081169
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.53898761
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.51643522
10TP53_16413492_ChIP-PET_HCT116_Human2.34131620
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.12931432
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.12453486
13ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.11154113
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.05190677
15CJUN_26792858_Chip-Seq_BT549_Human1.98925372
16EP300_21415370_ChIP-Seq_HL-1_Mouse1.98887044
17RBPJ_22232070_ChIP-Seq_NCS_Mouse1.98676405
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.97526278
19GATA2_21666600_ChIP-Seq_HMVEC_Human1.97317385
20DROSHA_22980978_ChIP-Seq_HELA_Human1.96969954
21PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.88765636
22ZNF217_24962896_ChIP-Seq_MCF-7_Human1.88676302
23CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.81337220
24BRD4_25478319_ChIP-Seq_HGPS_Human1.80418127
25Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.79928070
26PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.78130761
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.76856236
28CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.76593746
29VDR_22108803_ChIP-Seq_LS180_Human1.73603097
30RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.73187467
31SMAD4_21799915_ChIP-Seq_A2780_Human1.71631916
32PPAR_26484153_Chip-Seq_NCI-H1993_Human1.70583791
33STAT3_23295773_ChIP-Seq_U87_Human1.67038739
34TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.63918772
35CDX2_19796622_ChIP-Seq_MESCs_Mouse1.63901310
36SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.63050619
37EED_16625203_ChIP-ChIP_MESCs_Mouse1.60645365
38TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.60214878
39TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.60198491
40STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.59906030
41ESR1_20079471_ChIP-ChIP_T-47D_Human1.59534227
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.58713470
43WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.58533163
44AHR_22903824_ChIP-Seq_MCF-7_Human1.57608588
45SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.57443431
46RUNX_20019798_ChIP-Seq_JUKART_Human1.55785511
47JARID2_20064375_ChIP-Seq_MESCs_Mouse1.54409684
48DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.51642565
49SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.50988354
50FOXO3_23340844_ChIP-Seq_DLD1_Human1.50590444
51KDM2B_26808549_Chip-Seq_SUP-B15_Human1.49959322
52TCF4_23295773_ChIP-Seq_U87_Human1.48209136
53ZNF274_21170338_ChIP-Seq_K562_Hela1.47886189
54ARNT_22903824_ChIP-Seq_MCF-7_Human1.46196801
55NR3C1_21868756_ChIP-Seq_MCF10A_Human1.46133563
56JARID2_20075857_ChIP-Seq_MESCs_Mouse1.46003987
57RNF2_18974828_ChIP-Seq_MESCs_Mouse1.45297640
58EZH2_18974828_ChIP-Seq_MESCs_Mouse1.45297640
59EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.44990794
60P300_19829295_ChIP-Seq_ESCs_Human1.42970122
61RNF2_27304074_Chip-Seq_ESCs_Mouse1.42953122
62SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.41927626
63VDR_24787735_ChIP-Seq_THP-1_Human1.41517814
64POU3F2_20337985_ChIP-ChIP_501MEL_Human1.39174506
65VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.38475099
66CTBP1_25329375_ChIP-Seq_LNCAP_Human1.38421069
67EZH2_27304074_Chip-Seq_ESCs_Mouse1.38178149
68SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.38047267
69SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.38047267
70FOXM1_23109430_ChIP-Seq_U2OS_Human1.37357412
71SALL4_18804426_ChIP-ChIP_XEN_Mouse1.36825995
72CTNNB1_20460455_ChIP-Seq_HCT116_Human1.36786902
73SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36226166
74SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.35416793
75POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.34407508
76TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34407508
77SOX9_24532713_ChIP-Seq_HFSC_Mouse1.34230420
78SMAD3_21741376_ChIP-Seq_EPCs_Human1.33600329
79CLOCK_20551151_ChIP-Seq_293T_Human1.33532412
80TAF15_26573619_Chip-Seq_HEK293_Human1.33525061
81MYB_21317192_ChIP-Seq_ERMYB_Mouse1.33328264
82KDM2B_26808549_Chip-Seq_DND41_Human1.33025927
83STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.32674959
84ESR1_15608294_ChIP-ChIP_MCF-7_Human1.32245692
85SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.30440469
86SALL1_21062744_ChIP-ChIP_HESCs_Human1.30422180
87SPI1_23127762_ChIP-Seq_K562_Human1.30274533
88SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.29173830
89SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.29026046
90P300_27058665_Chip-Seq_ZR-75-30cells_Human1.28511151
91SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.28505471
92TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.28371853
93NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.28150561
94MTF2_20144788_ChIP-Seq_MESCs_Mouse1.26198910
95NRF2_20460467_ChIP-Seq_MEFs_Mouse1.26171506
96NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.26171506
97KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.26128569
98BCAT_22108803_ChIP-Seq_LS180_Human1.25896350
99MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.25366558
100AR_25329375_ChIP-Seq_VCAP_Human1.24955863
101FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.24904921
102BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.24873129
103EZH2_27294783_Chip-Seq_ESCs_Mouse1.24592679
104CBX2_27304074_Chip-Seq_ESCs_Mouse1.24566087
105TBX20_22328084_ChIP-Seq_HEART_Mouse1.23720238
106TBX20_22080862_ChIP-Seq_HEART_Mouse1.23720238
107TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23358440
108KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.22437811
109AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.22234641
110SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.22129087
111TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22127310
112TCF7_22412390_ChIP-Seq_EML_Mouse1.22122308
113ELK3_25401928_ChIP-Seq_HUVEC_Human1.21790193
114SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21688146
115IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.20409878
116ESR2_21235772_ChIP-Seq_MCF-7_Human1.20043644
117FOXA2_19822575_ChIP-Seq_HepG2_Human1.19657943
118GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19510676
119KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.19322061
120KDM2B_26808549_Chip-Seq_JURKAT_Human1.18351781
121IRF8_27001747_Chip-Seq_BMDM_Mouse1.18028370
122SMAD3_21741376_ChIP-Seq_HESCs_Human1.17953433
123NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.17287626
124OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17094621
125HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.16894075
126SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16827181
127UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16763934
128SOX2_21211035_ChIP-Seq_LN229_Gbm1.16245275
129FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.15129149
130FUS_26573619_Chip-Seq_HEK293_Human1.14588100
131RXR_22108803_ChIP-Seq_LS180_Human1.14227899
132KDM2B_26808549_Chip-Seq_REH_Human1.13951759
133ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.13817623
134ESR1_21235772_ChIP-Seq_MCF-7_Human1.13716566
135TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12421285
136SUZ12_27294783_Chip-Seq_ESCs_Mouse1.12398025
137REST_21632747_ChIP-Seq_MESCs_Mouse1.11946579
138PRDM14_20953172_ChIP-Seq_ESCs_Human1.11024074
139FLI1_27457419_Chip-Seq_LIVER_Mouse1.10997752
140WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10663347
141AR_19668381_ChIP-Seq_PC3_Human1.10158318
142RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.09854742
143ER_23166858_ChIP-Seq_MCF-7_Human1.09543240
144RUNX2_22187159_ChIP-Seq_PCA_Human1.09010870
145PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08514369
146MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08477639
147SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.08476256
148TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08280867
149CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.07977736
150TP53_18474530_ChIP-ChIP_U2OS_Human1.07729500
151FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.07590628
152AR_21572438_ChIP-Seq_LNCaP_Human1.07329975
153BP1_19119308_ChIP-ChIP_Hs578T_Human1.06991635
154UBF1/2_26484160_Chip-Seq_HMECs_Human1.06857825
155SMAD4_21741376_ChIP-Seq_HESCs_Human1.06686956
156PCGF2_27294783_Chip-Seq_ESCs_Mouse1.05344643
157TCF4_18268006_ChIP-ChIP_LS174T_Human1.05307990
158RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.04392601
159JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03667308
160ISL1_27105846_Chip-Seq_CPCs_Mouse1.03479076
161PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.03419825
162HIF1A_21447827_ChIP-Seq_MCF-7_Human1.03176814
163NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.02744064
164MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.02653033
165LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02651811
166KDM2B_26808549_Chip-Seq_K562_Human1.02584306
167ZFP281_27345836_Chip-Seq_ESCs_Mouse1.02035066
168TP63_23658742_ChIP-Seq_EP156T_Human1.01720862
169CBP_20019798_ChIP-Seq_JUKART_Human1.00793392
170IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.00793392
171SMAD3_21741376_ChIP-Seq_ESCs_Human1.00787811
172RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00340298
173STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.00106086
174FLI1_21867929_ChIP-Seq_TH2_Mouse0.99481832
175ATF3_27146783_Chip-Seq_COLON_Human0.99401966
176PIAS1_25552417_ChIP-Seq_VCAP_Human0.98236150

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.04868147
2MP0003705_abnormal_hypodermis_morpholog4.03632589
3MP0000569_abnormal_digit_pigmentation3.51308564
4MP0005503_abnormal_tendon_morphology3.14375230
5MP0003279_aneurysm2.95319628
6MP0005275_abnormal_skin_tensile2.81326472
7MP0010368_abnormal_lymphatic_system2.71444109
8MP0003566_abnormal_cell_adhesion2.63129961
9MP0003091_abnormal_cell_migration2.61235768
10MP0009384_cardiac_valve_regurgitation2.50324421
11MP0009780_abnormal_chondrocyte_physiolo2.45370593
12MP0005623_abnormal_meninges_morphology2.42913198
13MP0010352_gastrointestinal_tract_polyps2.38028568
14MP0001958_emphysema2.34951316
15MP0003300_gastrointestinal_ulcer2.27725849
16MP0004272_abnormal_basement_membrane2.20237384
17MP0003136_yellow_coat_color2.17556088
18MP0000767_abnormal_smooth_muscle2.03885341
19MP0005023_abnormal_wound_healing2.00429668
20MP0003045_fibrosis1.99739192
21MP0000733_abnormal_muscle_development1.92482697
22MP0003828_pulmonary_edema1.90918722
23MP0009046_muscle_twitch1.77659155
24MP0004510_myositis1.71638929
25MP0005171_absent_coat_pigmentation1.70377157
26MP0005257_abnormal_intraocular_pressure1.65573486
27MP0005076_abnormal_cell_differentiation1.65137241
28MP0004084_abnormal_cardiac_muscle1.64004222
29MP0004808_abnormal_hematopoietic_stem1.58263076
30MP0001879_abnormal_lymphatic_vessel1.57944500
31MP0003646_muscle_fatigue1.56691937
32MP0004185_abnormal_adipocyte_glucose1.51403275
33MP0005508_abnormal_skeleton_morphology1.51377794
34MP0001299_abnormal_eye_distance/1.49357919
35MP0010307_abnormal_tumor_latency1.47824280
36MP0004043_abnormal_pH_regulation1.47533291
37MP0000778_abnormal_nervous_system1.41690730
38MP0010386_abnormal_urinary_bladder1.41195229
39MP0005595_abnormal_vascular_smooth1.41006671
40MP0005551_abnormal_eye_electrophysiolog1.40766907
41MP0002877_abnormal_melanocyte_morpholog1.38338539
42MP0001501_abnormal_sleep_pattern1.35913964
43MP0010630_abnormal_cardiac_muscle1.34358367
44MP0004145_abnormal_muscle_electrophysio1.34189726
45MP0002925_abnormal_cardiovascular_devel1.33694137
46MP0000750_abnormal_muscle_regeneration1.33602461
47MP0001915_intracranial_hemorrhage1.31698198
48MP0008057_abnormal_DNA_replication1.31567752
49MP0002295_abnormal_pulmonary_circulatio1.30830779
50MP0002396_abnormal_hematopoietic_system1.30502116
51MP0002060_abnormal_skin_morphology1.30043022
52MP0009278_abnormal_bone_marrow1.29421105
53MP0005174_abnormal_tail_pigmentation1.28110451
54MP0003448_altered_tumor_morphology1.26759256
55MP0004087_abnormal_muscle_fiber1.26433176
56MP0002128_abnormal_blood_circulation1.24900762
57MP0004885_abnormal_endolymph1.24842453
58MP0002168_other_aberrant_phenotype1.24540359
59MP0004859_abnormal_synaptic_plasticity1.23757805
60MP0003385_abnormal_body_wall1.23539089
61MP0003890_abnormal_embryonic-extraembry1.23521372
62MP0006138_congestive_heart_failure1.23148247
63MP0000751_myopathy1.21984933
64MP0003635_abnormal_synaptic_transmissio1.21390586
65MP0001614_abnormal_blood_vessel1.21213016
66MP0000534_abnormal_ureter_morphology1.21033966
67MP0004215_abnormal_myocardial_fiber1.19696798
68MP0000427_abnormal_hair_cycle1.19342152
69MP0001968_abnormal_touch/_nociception1.13936751
70MP0006276_abnormal_autonomic_nervous1.13432923
71MP0000230_abnormal_systemic_arterial1.12855694
72MP0004484_altered_response_of1.12410764
73MP0003942_abnormal_urinary_system1.11205799
74MP0002166_altered_tumor_susceptibility1.11139658
75MP0002064_seizures1.11023428
76MP0005197_abnormal_uvea_morphology1.07407323
77MP0001486_abnormal_startle_reflex1.07223657
78MP0009745_abnormal_behavioral_response1.06464712
79MP0002272_abnormal_nervous_system1.05003290
80MP0002572_abnormal_emotion/affect_behav1.04503308
81MP0005397_hematopoietic_system_phenotyp1.04155137
82MP0001545_abnormal_hematopoietic_system1.04155137
83MP0005390_skeleton_phenotype1.03888550
84MP0001485_abnormal_pinna_reflex1.03390794
85MP0001851_eye_inflammation1.02971809
86MP0002006_tumorigenesis1.02864556
87MP0002933_joint_inflammation1.02588814
88MP0004036_abnormal_muscle_relaxation1.01054594
89MP0006054_spinal_hemorrhage1.00989711
90MP0000266_abnormal_heart_morphology1.00359191
91MP0002108_abnormal_muscle_morphology0.99373837
92MP0002067_abnormal_sensory_capabilities0.98554281
93MP0003303_peritoneal_inflammation0.98309763
94MP0003115_abnormal_respiratory_system0.95885856
95MP0004924_abnormal_behavior0.95808898
96MP0005386_behavior/neurological_phenoty0.95808898
97MP0003183_abnormal_peptide_metabolism0.95586480
98MP0005620_abnormal_muscle_contractility0.95383485
99MP0005385_cardiovascular_system_phenoty0.95206308
100MP0001544_abnormal_cardiovascular_syste0.95206308
101MP0003195_calcinosis0.95185581
102MP0002063_abnormal_learning/memory/cond0.94825044
103MP0000955_abnormal_spinal_cord0.94113797
104MP0000383_abnormal_hair_follicle0.93987434
105MP0000343_altered_response_to0.92820504
106MP0002557_abnormal_social/conspecific_i0.91482670
107MP0002733_abnormal_thermal_nociception0.90295000
108MP0009053_abnormal_anal_canal0.90278147
109MP0002998_abnormal_bone_remodeling0.89775627
110MP0001849_ear_inflammation0.89730013
111MP0003950_abnormal_plasma_membrane0.89541777
112MP0002896_abnormal_bone_mineralization0.88811649
113MP0003984_embryonic_growth_retardation0.88752267
114MP0002086_abnormal_extraembryonic_tissu0.88488000
115MP0000013_abnormal_adipose_tissue0.88162743
116MP0004085_abnormal_heartbeat0.87839926
117MP0002088_abnormal_embryonic_growth/wei0.87722269
118MP0003633_abnormal_nervous_system0.87500768
119MP0003879_abnormal_hair_cell0.85927568
120MP0000759_abnormal_skeletal_muscle0.85524294
121MP0002735_abnormal_chemical_nociception0.85504178
122MP0001970_abnormal_pain_threshold0.85408043
123MP0005409_darkened_coat_color0.85206138
124MP0009250_abnormal_appendicular_skeleto0.85054616
125MP0001533_abnormal_skeleton_physiology0.84773585
126MP0000749_muscle_degeneration0.84533656
127MP0005167_abnormal_blood-brain_barrier0.84422826
128MP0004142_abnormal_muscle_tone0.84009867
129MP0000428_abnormal_craniofacial_morphol0.83658294
130MP0002109_abnormal_limb_morphology0.83111202
131MP0005666_abnormal_adipose_tissue0.82970842
132MP0000249_abnormal_blood_vessel0.82042760
133MP0003937_abnormal_limbs/digits/tail_de0.81996198
134MP0001243_abnormal_dermal_layer0.81537138
135MP0008961_abnormal_basal_metabolism0.81431993
136MP0001175_abnormal_lung_morphology0.81256975
137MP0000432_abnormal_head_morphology0.80770747
138MP0002972_abnormal_cardiac_muscle0.80233110
139MP0000003_abnormal_adipose_tissue0.80212955
140MP0008775_abnormal_heart_ventricle0.79052967
141MP0003755_abnormal_palate_morphology0.78700613
142MP0003935_abnormal_craniofacial_develop0.78421346
143MP0003632_abnormal_nervous_system0.78150130
144MP0002882_abnormal_neuron_morphology0.77477785
145MP0000858_altered_metastatic_potential0.77297050
146MP0005375_adipose_tissue_phenotype0.76563732
147MP0004130_abnormal_muscle_cell0.76479598
148MP0009115_abnormal_fat_cell0.76428616
149MP0000538_abnormal_urinary_bladder0.75421128
150MP0002938_white_spotting0.74920054
151MP0002113_abnormal_skeleton_development0.74847986
152MP0003631_nervous_system_phenotype0.74738006
153MP0002115_abnormal_skeleton_extremities0.74374057
154MP0001440_abnormal_grooming_behavior0.73412067
155MP0005621_abnormal_cell_physiology0.73325236
156MP0002837_dystrophic_cardiac_calcinosis0.73133142
157MP0003878_abnormal_ear_physiology0.72902808
158MP0005377_hearing/vestibular/ear_phenot0.72902808
159MP0008007_abnormal_cellular_replicative0.72563787
160MP0005195_abnormal_posterior_eye0.71993157
161MP0005330_cardiomyopathy0.71964494
162MP0002116_abnormal_craniofacial_bone0.71041337
163MP0005670_abnormal_white_adipose0.69814824
164MP0005380_embryogenesis_phenotype0.69753390
165MP0001672_abnormal_embryogenesis/_devel0.69753390
166MP0002133_abnormal_respiratory_system0.69231951
167MP0005388_respiratory_system_phenotype0.69231951
168MP0001784_abnormal_fluid_regulation0.68151344

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.55369030
2Shallow orbits (HP:0000586)4.52566892
3Premature rupture of membranes (HP:0001788)4.29033913
4Aortic aneurysm (HP:0004942)4.15544303
5Cerebral aneurysm (HP:0004944)3.96452891
6Aortic dissection (HP:0002647)3.81496921
7Ankle contracture (HP:0006466)3.56520080
8Progressive cerebellar ataxia (HP:0002073)3.48036779
9Hyperventilation (HP:0002883)3.43994252
10Vascular tortuosity (HP:0004948)3.25773174
11Broad metatarsal (HP:0001783)3.23189779
12Cervical subluxation (HP:0003308)3.14823833
13Arterial tortuosity (HP:0005116)3.01469736
14Mitral valve prolapse (HP:0001634)3.01096955
15Peritonitis (HP:0002586)2.98382936
16Protruding tongue (HP:0010808)2.94242604
17Spondylolisthesis (HP:0003302)2.92763103
18Wrist flexion contracture (HP:0001239)2.91802454
19Genu recurvatum (HP:0002816)2.87131658
20Aneurysm (HP:0002617)2.84594306
21Dilatation of the ascending aorta (HP:0005111)2.77340360
22Atrophic scars (HP:0001075)2.68900420
23Increased connective tissue (HP:0009025)2.67734121
24Osteolytic defects of the hand bones (HP:0009699)2.60842271
25Osteolytic defects of the phalanges of the hand (HP:0009771)2.60842271
26Gaze-evoked nystagmus (HP:0000640)2.60360113
27Camptodactyly of toe (HP:0001836)2.58515395
28Pancreatic fibrosis (HP:0100732)2.57921954
29Tubular atrophy (HP:0000092)2.53345657
30Broad ribs (HP:0000885)2.51341773
31Bladder diverticulum (HP:0000015)2.50965081
32Nephronophthisis (HP:0000090)2.50296904
33Clumsiness (HP:0002312)2.47542674
34Spinal cord lesions (HP:0100561)2.42707456
35Syringomyelia (HP:0003396)2.42707456
36Soft skin (HP:0000977)2.42487730
37Narrow palate (HP:0000189)2.42240889
38Hematochezia (HP:0002573)2.42179001
39Abnormality of the renal medulla (HP:0100957)2.39074115
40Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.36213947
41Abnormality of the fingertips (HP:0001211)2.36116948
42Wormian bones (HP:0002645)2.35189703
43Increased corneal curvature (HP:0100692)2.27867179
44Keratoconus (HP:0000563)2.27867179
45Urethral obstruction (HP:0000796)2.27187118
46Blue sclerae (HP:0000592)2.26082607
47Pancreatic cysts (HP:0001737)2.25846737
48Abnormality of incisor morphology (HP:0011063)2.23825912
49Neonatal short-limb short stature (HP:0008921)2.20870305
50Bulbous nose (HP:0000414)2.18511876
51Distal lower limb amyotrophy (HP:0008944)2.16767244
52Febrile seizures (HP:0002373)2.15117917
53Disproportionate tall stature (HP:0001519)2.13019104
54Dysmetric saccades (HP:0000641)2.11182755
55Myocardial infarction (HP:0001658)2.10917368
56Focal seizures (HP:0007359)2.09956867
57Long eyelashes (HP:0000527)2.08640592
58Fragile skin (HP:0001030)2.07555328
59Increased density of long bones (HP:0006392)2.06308704
60Short 4th metacarpal (HP:0010044)2.05329942
61Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.05329942
62Hyperextensible skin (HP:0000974)2.04538563
63Overgrowth (HP:0001548)2.04449359
64Chronic hepatic failure (HP:0100626)2.03731257
65Vertebral compression fractures (HP:0002953)2.03314797
66Fair hair (HP:0002286)2.02499641
67Acute myeloid leukemia (HP:0004808)2.01451487
68Congenital stationary night blindness (HP:0007642)2.01408350
69Tracheomalacia (HP:0002779)2.00939696
70Preaxial foot polydactyly (HP:0001841)2.00745044
71Striae distensae (HP:0001065)1.97893027
72Absent frontal sinuses (HP:0002688)1.97299025
73Renovascular hypertension (HP:0100817)1.96073185
74Flat cornea (HP:0007720)1.95889766
75Subacute progressive viral hepatitis (HP:0006572)1.95682395
76Flexion contracture of toe (HP:0005830)1.95308364
77Joint contractures involving the joints of the feet (HP:0100492)1.95308364
78Prolonged QT interval (HP:0001657)1.94675362
79Broad-based gait (HP:0002136)1.94494689
80Abnormality of midbrain morphology (HP:0002418)1.94458232
81Molar tooth sign on MRI (HP:0002419)1.94458232
82Joint laxity (HP:0001388)1.94208720
83Decreased circulating renin level (HP:0003351)1.94153451
84Cystic liver disease (HP:0006706)1.93404851
85Aortic valve stenosis (HP:0001650)1.93205398
86Flared iliac wings (HP:0002869)1.90792625
87Absent speech (HP:0001344)1.89742638
88Hypoplastic labia majora (HP:0000059)1.87015644
89Hypoplasia of the iris (HP:0007676)1.85959678
90Drooling (HP:0002307)1.83368855
91Abnormality of the nasal septum (HP:0000419)1.82361226
92Congenital hepatic fibrosis (HP:0002612)1.82301158
93Hypoplastic ischia (HP:0003175)1.82162308
94Polycythemia (HP:0001901)1.81991030
95Abnormality of the renal cortex (HP:0011035)1.81618048
96Lower limb amyotrophy (HP:0007210)1.81228120
97Aplasia/Hypoplasia of the tibia (HP:0005772)1.80806434
98Abnormality of the acetabulum (HP:0003170)1.79584055
99True hermaphroditism (HP:0010459)1.79247479
100Spinal rigidity (HP:0003306)1.79060844
101Mitral regurgitation (HP:0001653)1.79035553
102Type 1 muscle fiber predominance (HP:0003803)1.78719792
103Infantile muscular hypotonia (HP:0008947)1.78352239
104Arachnodactyly (HP:0001166)1.78129474
105Long toe (HP:0010511)1.77882486
106Widely spaced teeth (HP:0000687)1.77319496
107Atonic seizures (HP:0010819)1.77032292
108Bowel diverticulosis (HP:0005222)1.76936014
109Cardiovascular calcification (HP:0011915)1.76329625
110Atrial fibrillation (HP:0005110)1.75838429
111Hip contracture (HP:0003273)1.74752650
112Abnormality of the labia majora (HP:0012881)1.74093117
113Short nail (HP:0001799)1.73262703
114Abnormality of the peritoneum (HP:0002585)1.73115908
115Dislocated radial head (HP:0003083)1.72347523
116Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.72203243
117Bell-shaped thorax (HP:0001591)1.71671583
118Truncal obesity (HP:0001956)1.71141798
119Short foot (HP:0001773)1.70351830
120Enlarged penis (HP:0000040)1.69745337
121Hyperkalemia (HP:0002153)1.69269674
122Persistence of primary teeth (HP:0006335)1.68805604
123Capillary hemangiomas (HP:0005306)1.68621031
124Bronchomalacia (HP:0002780)1.67755178
125Morphological abnormality of the middle ear (HP:0008609)1.67467193
126Increased number of teeth (HP:0011069)1.66485389
127Hyporeflexia of lower limbs (HP:0002600)1.66445869
128Supraventricular arrhythmia (HP:0005115)1.66092210
129Follicular hyperkeratosis (HP:0007502)1.66049222
130Coronal craniosynostosis (HP:0004440)1.65031679
131Thin bony cortex (HP:0002753)1.64689412
132Supraventricular tachycardia (HP:0004755)1.64351782
133Abnormal drinking behavior (HP:0030082)1.64339023
134Polydipsia (HP:0001959)1.64339023
135Hypoplastic iliac wings (HP:0002866)1.63654939
136Generalized hypopigmentation of hair (HP:0011358)1.63334780
137Scapular winging (HP:0003691)1.63131695
138Macroglossia (HP:0000158)1.62550805
139Radial bowing (HP:0002986)1.62149125
140Primary atrial arrhythmia (HP:0001692)1.61252704
141Venous abnormality (HP:0002624)1.61208707
142Fibular hypoplasia (HP:0003038)1.60781694
143Inguinal hernia (HP:0000023)1.60730265
144Abnormal delivery (HP:0001787)1.60294239
145Abnormality of the 4th metacarpal (HP:0010012)1.59244267
146Muscle fiber splitting (HP:0003555)1.59230882
147Right ventricular cardiomyopathy (HP:0011663)1.58905463
148Obstructive sleep apnea (HP:0002870)1.58887252
149Broad long bones (HP:0005622)1.58593678
150Hypoplastic nipples (HP:0002557)1.58479532
151Diplopia (HP:0000651)1.58367243
152Abnormality of binocular vision (HP:0011514)1.58367243
153Abnormality of the distal phalanx of the thumb (HP:0009617)1.57354277
154Coxa vara (HP:0002812)1.57048890
155Knee flexion contracture (HP:0006380)1.56981284
156Pulmonary artery stenosis (HP:0004415)1.56269613
157Elbow flexion contracture (HP:0002987)1.56033095
158Broad thumb (HP:0011304)1.55413515
159Abnormality of the radial head (HP:0003995)1.55345418
160Wide anterior fontanel (HP:0000260)1.54276550
161Genetic anticipation (HP:0003743)1.53630493
162Trigonocephaly (HP:0000243)1.52939120
163Abnormality of the ischium (HP:0003174)1.51747370
164Limited hip movement (HP:0008800)1.51662393
165Protruding ear (HP:0000411)1.51640814
166Aortic regurgitation (HP:0001659)1.51457775
167Hypoplasia of the maxilla (HP:0000327)1.51417773
168Coarse hair (HP:0002208)1.51243003

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS16.15456028
2EPHA33.46125486
3LATS23.45130132
4AKT32.89466248
5ACVR1B2.69424196
6TTN2.58840433
7CDK122.55917019
8PDGFRA2.54787576
9DMPK2.29338738
10STK32.27016761
11BMPR1B2.18635506
12TAOK12.09154615
13TRIB32.06153095
14CASK1.99996809
15NTRK31.99071423
16CAMK1D1.97538932
17MARK11.94679783
18RIPK11.87413567
19BRD41.82173316
20MYLK1.78651400
21WNK41.78261824
22NUAK11.75849782
23STK38L1.71526135
24TRPM71.68648306
25PKN21.67958443
26TIE11.63778276
27ADRBK21.60272161
28PDGFRB1.56279241
29STK391.55590389
30CAMK1G1.51769981
31TNIK1.47899602
32TGFBR21.46114778
33PRKD21.45655663
34CAMKK21.45451474
35EPHB11.44009622
36SGK21.42430059
37DDR21.40246728
38PNCK1.36848152
39JAK11.33604596
40STK381.29691937
41INSRR1.26934204
42ADRBK11.23778896
43JAK31.20896952
44STK101.17649607
45EEF2K1.16360586
46TGFBR11.15425897
47PTK21.10674464
48GRK11.10509438
49SGK2231.07870017
50SGK4941.07870017
51PTK2B1.04598950
52PRPF4B1.01838065
53KIT1.01000306
54PAK21.00736619
55SIK10.99490237
56ERBB40.98133771
57PTK60.96682095
58NEK90.94786194
59PIK3CA0.94414280
60MTOR0.91980388
61CDK90.91439174
62NTRK20.91366002
63PIK3CG0.91331393
64OBSCN0.91060721
65CAMK10.90792450
66BRSK20.90183219
67TYRO30.90033798
68FGFR30.89426216
69TAOK20.89112864
70ICK0.87860118
71MAPK130.87193625
72DAPK20.86983973
73CDK60.86723731
74MKNK20.86313604
75WNK10.85724663
76MAPK150.84550182
77PINK10.84456400
78PAK30.84076046
79BMX0.82795100
80EPHB20.82562690
81CDC70.82047835
82PAK60.81672351
83ABL20.81304387
84PRKD10.80705185
85MAP3K60.79481639
86KSR20.79117904
87TAOK30.78376442
88CAMKK10.77605596
89MAP3K40.76532220
90RET0.73756894
91PRKAA20.72850317
92ERN10.71950668
93PRKCE0.71391255
94PAK40.70172052
95HCK0.69884679
96NLK0.69255125
97MARK20.66244345
98KDR0.65582683
99NEK20.65231982
100RPS6KA40.65098559
101OXSR10.64618051
102SGK10.62701620
103TEC0.59842913
104CHUK0.59616347
105MELK0.58157293
106MET0.57635399
107MOS0.57518441
108RPS6KA20.57045318
109CAMK2A0.56154280
110ABL10.55654981
111PRKCG0.55133160
112PKN10.54749944
113MAP3K130.54160234
114SCYL20.52357739
115RAF10.52007465
116PRKG10.51975974
117MAPK70.51455894
118FGFR20.49490425
119PRKD30.49313161
120PRKCH0.49050460
121LRRK20.48061513
122MAPKAPK50.48057592
123TYK20.47667862
124RPS6KA30.47538674
125MARK30.47262582
126CDK80.46377783
127RPS6KA60.45468980
128MAPK100.44698591
129ROCK10.43768225
130SGK30.43325650
131CAMK40.43100723
132FER0.42781386
133WNK30.42093879
134NTRK10.41695601
135MAP3K70.41494186
136MAP2K10.41027748
137GRK70.40361988
138CDK50.40008945
139MAP3K50.39377638
140FGFR10.38707434
141CSF1R0.38563969
142FGFR40.38492938
143MAPK120.38429210
144STK110.38210609
145DYRK1A0.37916182
146FRK0.36230312
147PRKAA10.34268965
148CDC42BPA0.33775564
149PDPK10.32994036
150CDK40.32563697
151MAPK10.31259020
152PLK20.30858237
153IGF1R0.30708243
154EGFR0.30664006
155KSR10.30633848

Predicted pathways (KEGG)

RankGene SetZ-score
1Adherens junction_Homo sapiens_hsa045201.97603208
2Focal adhesion_Homo sapiens_hsa045101.95073219
3ECM-receptor interaction_Homo sapiens_hsa045121.95049042
4Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.79406451
5Nicotine addiction_Homo sapiens_hsa050331.79181327
6Glutamatergic synapse_Homo sapiens_hsa047241.79050276
7Dilated cardiomyopathy_Homo sapiens_hsa054141.78869110
8Circadian entrainment_Homo sapiens_hsa047131.75469860
9Pancreatic cancer_Homo sapiens_hsa052121.75150631
10Morphine addiction_Homo sapiens_hsa050321.70884335
11Insulin secretion_Homo sapiens_hsa049111.68952934
12Proteoglycans in cancer_Homo sapiens_hsa052051.68696636
13Small cell lung cancer_Homo sapiens_hsa052221.67601542
14Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.62904112
15MicroRNAs in cancer_Homo sapiens_hsa052061.62513491
16Chronic myeloid leukemia_Homo sapiens_hsa052201.62304255
17AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.56379160
18Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.53034004
19Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.52941750
20Taste transduction_Homo sapiens_hsa047421.48548851
21Calcium signaling pathway_Homo sapiens_hsa040201.47565466
22Viral myocarditis_Homo sapiens_hsa054161.47277798
23ABC transporters_Homo sapiens_hsa020101.46746242
24Amoebiasis_Homo sapiens_hsa051461.42946498
25Protein digestion and absorption_Homo sapiens_hsa049741.41881854
26GABAergic synapse_Homo sapiens_hsa047271.41250166
27TGF-beta signaling pathway_Homo sapiens_hsa043501.40398653
28Gastric acid secretion_Homo sapiens_hsa049711.38834895
29Regulation of actin cytoskeleton_Homo sapiens_hsa048101.36417436
30Salivary secretion_Homo sapiens_hsa049701.35199721
31Cholinergic synapse_Homo sapiens_hsa047251.32212853
32Osteoclast differentiation_Homo sapiens_hsa043801.29753935
33Malaria_Homo sapiens_hsa051441.29316006
34Aldosterone synthesis and secretion_Homo sapiens_hsa049251.28688374
35Glioma_Homo sapiens_hsa052141.27473504
36Leukocyte transendothelial migration_Homo sapiens_hsa046701.26967461
37Cocaine addiction_Homo sapiens_hsa050301.26724821
38Toxoplasmosis_Homo sapiens_hsa051451.24901018
39Renin secretion_Homo sapiens_hsa049241.24119561
40Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.21324752
41VEGF signaling pathway_Homo sapiens_hsa043701.19673827
42Leishmaniasis_Homo sapiens_hsa051401.18995866
43Renal cell carcinoma_Homo sapiens_hsa052111.18290560
44Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.17715939
45Colorectal cancer_Homo sapiens_hsa052101.17212744
46mTOR signaling pathway_Homo sapiens_hsa041501.16568573
47Platelet activation_Homo sapiens_hsa046111.15603396
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.15464047
49Serotonergic synapse_Homo sapiens_hsa047261.14902071
50Endometrial cancer_Homo sapiens_hsa052131.12566883
51Thyroid hormone signaling pathway_Homo sapiens_hsa049191.11039776
52Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.10690938
53Hedgehog signaling pathway_Homo sapiens_hsa043401.10214427
54Bladder cancer_Homo sapiens_hsa052191.09774215
55Rap1 signaling pathway_Homo sapiens_hsa040151.08599057
56Phototransduction_Homo sapiens_hsa047441.08368517
57TNF signaling pathway_Homo sapiens_hsa046681.05290828
58p53 signaling pathway_Homo sapiens_hsa041151.04737573
59alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.04131468
60Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.03907034
61Linoleic acid metabolism_Homo sapiens_hsa005911.03685631
62Long-term depression_Homo sapiens_hsa047301.03640912
63Lysine degradation_Homo sapiens_hsa003101.03546395
64Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.02513367
65B cell receptor signaling pathway_Homo sapiens_hsa046621.01345911
66Non-small cell lung cancer_Homo sapiens_hsa052231.00832349
67Pancreatic secretion_Homo sapiens_hsa049721.00425971
68Dopaminergic synapse_Homo sapiens_hsa047281.00329332
69Melanoma_Homo sapiens_hsa052181.00283009
70Hepatitis B_Homo sapiens_hsa051610.99204346
71Nitrogen metabolism_Homo sapiens_hsa009100.99094820
72Shigellosis_Homo sapiens_hsa051310.97596401
73Amphetamine addiction_Homo sapiens_hsa050310.97541801
74Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.97329409
75Prostate cancer_Homo sapiens_hsa052150.97186134
76Melanogenesis_Homo sapiens_hsa049160.96711458
77Dorso-ventral axis formation_Homo sapiens_hsa043200.96008981
78Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.94978941
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.92802744
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.92625847
81HIF-1 signaling pathway_Homo sapiens_hsa040660.92257962
82Prolactin signaling pathway_Homo sapiens_hsa049170.92107751
83FoxO signaling pathway_Homo sapiens_hsa040680.91793284
84Basal cell carcinoma_Homo sapiens_hsa052170.91370918
85Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.89799948
86Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.89493781
87Gap junction_Homo sapiens_hsa045400.89178187
88Hippo signaling pathway_Homo sapiens_hsa043900.88916637
89ErbB signaling pathway_Homo sapiens_hsa040120.88663657
90MAPK signaling pathway_Homo sapiens_hsa040100.87403529
91Choline metabolism in cancer_Homo sapiens_hsa052310.87381764
92HTLV-I infection_Homo sapiens_hsa051660.87302130
93Staphylococcus aureus infection_Homo sapiens_hsa051500.86544169
94Acute myeloid leukemia_Homo sapiens_hsa052210.86529835
95Pathways in cancer_Homo sapiens_hsa052000.86251311
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.86029178
97Olfactory transduction_Homo sapiens_hsa047400.85467957
98Tryptophan metabolism_Homo sapiens_hsa003800.85254425
99Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.82379172
100Chemokine signaling pathway_Homo sapiens_hsa040620.82099391
101GnRH signaling pathway_Homo sapiens_hsa049120.82093375
102Measles_Homo sapiens_hsa051620.82060098
103Longevity regulating pathway - mammal_Homo sapiens_hsa042110.81981254
104Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.81854754
105Toll-like receptor signaling pathway_Homo sapiens_hsa046200.81815098
106cGMP-PKG signaling pathway_Homo sapiens_hsa040220.81467609
107Circadian rhythm_Homo sapiens_hsa047100.81357430
108Jak-STAT signaling pathway_Homo sapiens_hsa046300.81346104
109Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.81245064
110Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.80880848
111NF-kappa B signaling pathway_Homo sapiens_hsa040640.80589300
112Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.80118929
113PI3K-Akt signaling pathway_Homo sapiens_hsa041510.78685416
114Insulin resistance_Homo sapiens_hsa049310.77965251
115Thyroid hormone synthesis_Homo sapiens_hsa049180.77596961
116Glycerolipid metabolism_Homo sapiens_hsa005610.77537727
117Notch signaling pathway_Homo sapiens_hsa043300.77102302
118Bile secretion_Homo sapiens_hsa049760.76198533
119Oxytocin signaling pathway_Homo sapiens_hsa049210.75641058
120Histidine metabolism_Homo sapiens_hsa003400.75581232
121Endocytosis_Homo sapiens_hsa041440.75484443
122Ras signaling pathway_Homo sapiens_hsa040140.75466864
123Type II diabetes mellitus_Homo sapiens_hsa049300.74904140
124Tuberculosis_Homo sapiens_hsa051520.74894076
125Apoptosis_Homo sapiens_hsa042100.73206754
126Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.73001711
127Phosphatidylinositol signaling system_Homo sapiens_hsa040700.72327348
128Salmonella infection_Homo sapiens_hsa051320.71720886
129Axon guidance_Homo sapiens_hsa043600.71023496
130Glycosaminoglycan degradation_Homo sapiens_hsa005310.70907307
131Ovarian steroidogenesis_Homo sapiens_hsa049130.70483508
132Ether lipid metabolism_Homo sapiens_hsa005650.69635596
133Estrogen signaling pathway_Homo sapiens_hsa049150.69632627
134Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.69578351
135Tight junction_Homo sapiens_hsa045300.66892908
136Transcriptional misregulation in cancer_Homo sapiens_hsa052020.65726345
137T cell receptor signaling pathway_Homo sapiens_hsa046600.64484732
138cAMP signaling pathway_Homo sapiens_hsa040240.63884503
139Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.63605312
140Wnt signaling pathway_Homo sapiens_hsa043100.62947271
141Long-term potentiation_Homo sapiens_hsa047200.62537110
142Vascular smooth muscle contraction_Homo sapiens_hsa042700.62516669
143Selenocompound metabolism_Homo sapiens_hsa004500.57989840
144Influenza A_Homo sapiens_hsa051640.57587502
145Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.56650832
146Central carbon metabolism in cancer_Homo sapiens_hsa052300.56015056
147Adipocytokine signaling pathway_Homo sapiens_hsa049200.55244652
148Insulin signaling pathway_Homo sapiens_hsa049100.54626112
149Butanoate metabolism_Homo sapiens_hsa006500.53177331
150Steroid hormone biosynthesis_Homo sapiens_hsa001400.51979761
151Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.50418632

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