PDZD9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement (GO:0003351)9.93048023
2axonemal dynein complex assembly (GO:0070286)9.41303923
3sperm-egg recognition (GO:0035036)9.36504993
4acrosome reaction (GO:0007340)9.32322533
5multicellular organism reproduction (GO:0032504)9.26375361
6plasma membrane fusion (GO:0045026)8.73533362
7binding of sperm to zona pellucida (GO:0007339)8.55593092
8cilium movement (GO:0003341)8.31945478
9cell-cell recognition (GO:0009988)8.26653222
10motile cilium assembly (GO:0044458)8.00723527
11spermatid development (GO:0007286)7.85619192
12epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.85320493
13piRNA metabolic process (GO:0034587)7.57562607
14reproduction (GO:0000003)7.56753900
15regulation of cilium movement (GO:0003352)7.06972921
16male meiosis (GO:0007140)6.74678729
17single fertilization (GO:0007338)6.45867943
18sperm capacitation (GO:0048240)6.05721067
19synaptonemal complex organization (GO:0070193)6.00502882
20negative regulation of inclusion body assembly (GO:0090084)5.65273023
21synaptonemal complex assembly (GO:0007130)5.61999915
22microtubule depolymerization (GO:0007019)5.38569195
23DNA methylation involved in gamete generation (GO:0043046)5.34602245
24fertilization (GO:0009566)5.30118902
25GTP biosynthetic process (GO:0006183)5.23614368
26ventricular system development (GO:0021591)5.17790192
27spermatogenesis (GO:0007283)5.10372653
28male gamete generation (GO:0048232)5.09108230
29male meiosis I (GO:0007141)4.87509246
30cell recognition (GO:0008037)4.76819843
31protein localization to cilium (GO:0061512)4.69889335
32gamete generation (GO:0007276)4.69323363
33calcium ion-dependent exocytosis (GO:0017156)4.68155207
34spermatid nucleus differentiation (GO:0007289)4.63432187
35left/right pattern formation (GO:0060972)4.49557695
36UTP biosynthetic process (GO:0006228)4.46155670
37germ cell development (GO:0007281)4.39401679
38regulation of inclusion body assembly (GO:0090083)4.35163625
39cellular process involved in reproduction in multicellular organism (GO:0022412)4.31989905
40tryptophan catabolic process (GO:0006569)4.28538189
41indole-containing compound catabolic process (GO:0042436)4.28538189
42indolalkylamine catabolic process (GO:0046218)4.28538189
43chromosome organization involved in meiosis (GO:0070192)4.25488072
44regulation of microtubule-based movement (GO:0060632)4.23292301
45intraciliary transport (GO:0042073)4.19810438
46nucleoside diphosphate phosphorylation (GO:0006165)4.19120313
47microtubule severing (GO:0051013)4.16183705
48indolalkylamine metabolic process (GO:0006586)4.07953522
49cellular ketone body metabolic process (GO:0046950)4.07097607
50behavioral response to nicotine (GO:0035095)3.98499130
51detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.94758016
52UTP metabolic process (GO:0046051)3.93765564
53photoreceptor cell maintenance (GO:0045494)3.92407596
54meiotic nuclear division (GO:0007126)3.92323229
55organic cation transport (GO:0015695)3.89765068
56response to pheromone (GO:0019236)3.83814631
57meiosis I (GO:0007127)3.70735004
58detection of light stimulus involved in sensory perception (GO:0050962)3.67617904
59detection of light stimulus involved in visual perception (GO:0050908)3.67617904
60tryptophan metabolic process (GO:0006568)3.63234817
61kynurenine metabolic process (GO:0070189)3.63185893
62L-fucose metabolic process (GO:0042354)3.63167622
63L-fucose catabolic process (GO:0042355)3.63167622
64fucose catabolic process (GO:0019317)3.63167622
65multicellular organismal reproductive process (GO:0048609)3.62910447
66seminiferous tubule development (GO:0072520)3.62208464
67retinal cone cell development (GO:0046549)3.60270259
68neural tube formation (GO:0001841)3.60080551
69guanosine-containing compound biosynthetic process (GO:1901070)3.59324273
70ketone body metabolic process (GO:1902224)3.56018868
71glycerol ether metabolic process (GO:0006662)3.54698676
72nonmotile primary cilium assembly (GO:0035058)3.54446164
73meiotic cell cycle (GO:0051321)3.51875303
74signal peptide processing (GO:0006465)3.47558435
75CTP biosynthetic process (GO:0006241)3.47413445
76CTP metabolic process (GO:0046036)3.47413445
77behavioral response to ethanol (GO:0048149)3.45266282
78axoneme assembly (GO:0035082)3.42629894
79positive regulation of action potential (GO:0045760)3.42535785
80proline transport (GO:0015824)3.41051008
81establishment of protein localization to Golgi (GO:0072600)3.39278530
82reflex (GO:0060004)3.33329530
83indole-containing compound metabolic process (GO:0042430)3.33181236
84ether metabolic process (GO:0018904)3.32632744
85protein polyglutamylation (GO:0018095)3.31966652
86cilium morphogenesis (GO:0060271)3.30961703
87neuronal action potential (GO:0019228)3.29826850
88cilium organization (GO:0044782)3.23647443
89negative regulation of cytosolic calcium ion concentration (GO:0051481)3.21127525
90regulation of action potential (GO:0098900)3.17611352
91rRNA catabolic process (GO:0016075)3.17095096
92cilium assembly (GO:0042384)3.15734213
93microtubule-based movement (GO:0007018)3.15511743
94microtubule polymerization or depolymerization (GO:0031109)3.12332055
95chaperone-mediated protein complex assembly (GO:0051131)3.10151695
96presynaptic membrane assembly (GO:0097105)3.09184971
97tachykinin receptor signaling pathway (GO:0007217)3.08903973
98cellular biogenic amine catabolic process (GO:0042402)3.05294785
99amine catabolic process (GO:0009310)3.05294785
100gamma-aminobutyric acid transport (GO:0015812)3.03595208
101pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.02357128
102benzene-containing compound metabolic process (GO:0042537)3.01217263
103cellular component assembly involved in morphogenesis (GO:0010927)3.00620257
104pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.95832821
105protein K63-linked deubiquitination (GO:0070536)2.95621139
106multicellular organismal development (GO:0007275)2.93099011
107G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.90213840
108photoreceptor cell development (GO:0042461)2.90091302
109protein K48-linked deubiquitination (GO:0071108)2.89333647
110C4-dicarboxylate transport (GO:0015740)2.84904958
111alditol metabolic process (GO:0019400)2.84224835
112positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.82331220
113polyol catabolic process (GO:0046174)2.80966146
114synapsis (GO:0007129)2.80801230
115protein K11-linked deubiquitination (GO:0035871)2.79300799
116primary amino compound metabolic process (GO:1901160)2.78327743
117NAD biosynthetic process (GO:0009435)2.78229621
118regulation of acrosome reaction (GO:0060046)2.76840737
119cornea development in camera-type eye (GO:0061303)2.76058492
120inositol phosphate catabolic process (GO:0071545)2.73122790
121single strand break repair (GO:0000012)2.72902019
122dopamine transport (GO:0015872)2.72653065
123pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.72051957
124presynaptic membrane organization (GO:0097090)2.71549053
125righting reflex (GO:0060013)2.70744856
126serotonin metabolic process (GO:0042428)2.68944033
127regulation of neurotransmitter uptake (GO:0051580)2.68933452
128genitalia morphogenesis (GO:0035112)2.68155026
129chromosome condensation (GO:0030261)2.67245851
130protein targeting to Golgi (GO:0000042)2.66864576
131glycerol metabolic process (GO:0006071)2.65904382
132regulation of protein kinase C signaling (GO:0090036)2.64820770
133regulation of hippo signaling (GO:0035330)2.64631170
134monoubiquitinated protein deubiquitination (GO:0035520)2.64500425
135eye photoreceptor cell development (GO:0042462)2.62193385
136protein prenylation (GO:0018342)2.61464846
137prenylation (GO:0097354)2.61464846
138pyrimidine dimer repair (GO:0006290)2.60770133
139phasic smooth muscle contraction (GO:0014821)2.60081085
140aromatic amino acid family catabolic process (GO:0009074)2.59445224
141protein refolding (GO:0042026)2.59003809
142oxidative demethylation (GO:0070989)2.58873013
143purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.58440452
144neuronal action potential propagation (GO:0019227)2.57391713
145detection of mechanical stimulus involved in sensory perception (GO:0050974)2.57203520
146pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.56785863
147transmission of nerve impulse (GO:0019226)2.56521572
148central nervous system neuron axonogenesis (GO:0021955)2.56441343
149positive regulation of developmental pigmentation (GO:0048087)2.56156005
150pyrimidine nucleobase catabolic process (GO:0006208)2.55089491
151negative regulation of mast cell activation (GO:0033004)2.53518610
152glycerophospholipid catabolic process (GO:0046475)2.52144711
153nucleobase catabolic process (GO:0046113)2.51972633
154retrograde transport, vesicle recycling within Golgi (GO:0000301)2.51453969
155DNA packaging (GO:0006323)2.51350777
156postsynaptic membrane organization (GO:0001941)2.50424802
157interkinetic nuclear migration (GO:0022027)2.50004625
158positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.49697729
159centriole assembly (GO:0098534)2.49197637
160purine nucleoside triphosphate biosynthetic process (GO:0009145)2.48682668
161lactate metabolic process (GO:0006089)2.48176269
162inner ear receptor stereocilium organization (GO:0060122)2.46950287
163negative regulation of neurotransmitter transport (GO:0051589)2.46870297
164regulation of sarcomere organization (GO:0060297)2.46836171
165startle response (GO:0001964)2.45673211
166regulation of spindle checkpoint (GO:0090231)2.43327176
167centriole replication (GO:0007099)2.43037994
168peristalsis (GO:0030432)2.42966876
169membrane depolarization during action potential (GO:0086010)2.42554539
170positive regulation of sodium ion transmembrane transport (GO:1902307)2.42387096
171neurotransmitter-gated ion channel clustering (GO:0072578)2.41765265
172meiotic cell cycle process (GO:1903046)2.40465618
173neuron cell-cell adhesion (GO:0007158)2.34784714
174protein localization to synapse (GO:0035418)2.32203481
175regulation of cytokine production involved in inflammatory response (GO:1900015)2.30549739
176hydrogen ion transmembrane transport (GO:1902600)2.26656564
177cilium or flagellum-dependent cell motility (GO:0001539)11.4371305
178fusion of sperm to egg plasma membrane (GO:0007342)11.3115658
179acrosome assembly (GO:0001675)10.9174543
180sperm motility (GO:0030317)10.6078571
181cell wall macromolecule metabolic process (GO:0044036)10.1597844
182cell wall macromolecule catabolic process (GO:0016998)10.1597844

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse7.51917874
2EZH2_22144423_ChIP-Seq_EOC_Human6.73412211
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.45343276
4IGF1R_20145208_ChIP-Seq_DFB_Human2.89811647
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.82136042
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.70436427
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.62763846
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.62396473
9ZNF274_21170338_ChIP-Seq_K562_Hela2.42701030
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.39110596
11VDR_22108803_ChIP-Seq_LS180_Human2.36264183
12PCGF2_27294783_Chip-Seq_ESCs_Mouse2.34760820
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.33399098
14TAF15_26573619_Chip-Seq_HEK293_Human2.25346408
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.22533612
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.21001256
17CBX2_27304074_Chip-Seq_ESCs_Mouse2.10181391
18ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.08315919
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.05594904
20EWS_26573619_Chip-Seq_HEK293_Human2.02132392
21EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.94273313
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.93832089
23GBX2_23144817_ChIP-Seq_PC3_Human1.89945265
24PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.86265728
25STAT3_23295773_ChIP-Seq_U87_Human1.80821640
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.76157630
27NFE2_27457419_Chip-Seq_LIVER_Mouse1.70336655
28SUZ12_27294783_Chip-Seq_NPCs_Mouse1.68694140
29NR3C1_21868756_ChIP-Seq_MCF10A_Human1.65643009
30RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.64858272
31PIAS1_25552417_ChIP-Seq_VCAP_Human1.62817557
32KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.60001127
33TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.58884735
34PCGF2_27294783_Chip-Seq_NPCs_Mouse1.58721540
35RNF2_27304074_Chip-Seq_NSC_Mouse1.57849753
36AR_25329375_ChIP-Seq_VCAP_Human1.57782404
37REST_21632747_ChIP-Seq_MESCs_Mouse1.57195447
38NANOG_18555785_Chip-Seq_ESCs_Mouse1.57155133
39TAL1_26923725_Chip-Seq_HPCs_Mouse1.55897911
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54823555
41EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.53668830
42BCAT_22108803_ChIP-Seq_LS180_Human1.52733616
43POU3F2_20337985_ChIP-ChIP_501MEL_Human1.52719551
44ER_23166858_ChIP-Seq_MCF-7_Human1.50750346
45P53_22387025_ChIP-Seq_ESCs_Mouse1.50463561
46FUS_26573619_Chip-Seq_HEK293_Human1.46905277
47P300_18555785_Chip-Seq_ESCs_Mouse1.46075588
48EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.45852137
49E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.40908805
50PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.40844616
51SUZ12_18555785_Chip-Seq_ESCs_Mouse1.39302071
52EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.38363534
53KDM2B_26808549_Chip-Seq_REH_Human1.37637645
54CMYC_18555785_Chip-Seq_ESCs_Mouse1.36647849
55AR_21572438_ChIP-Seq_LNCaP_Human1.36587927
56MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.36277034
57OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34841137
58OCT4_18555785_Chip-Seq_ESCs_Mouse1.34457286
59EZH2_27294783_Chip-Seq_NPCs_Mouse1.34320815
60TCF4_22108803_ChIP-Seq_LS180_Human1.33527199
61RUNX2_22187159_ChIP-Seq_PCA_Human1.32974032
62SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.31867349
63CBP_20019798_ChIP-Seq_JUKART_Human1.31198947
64IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.31198947
65PRDM14_20953172_ChIP-Seq_ESCs_Human1.30673220
66E2F1_18555785_Chip-Seq_ESCs_Mouse1.29280517
67CRX_20693478_ChIP-Seq_RETINA_Mouse1.29219469
68TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.28516597
69MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26300701
70POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.25650889
71TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25650889
72CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.25634108
73CDX2_19796622_ChIP-Seq_MESCs_Mouse1.25218862
74SOX2_18555785_Chip-Seq_ESCs_Mouse1.24293735
75SMAD4_21741376_ChIP-Seq_EPCs_Human1.23824968
76KLF4_18555785_Chip-Seq_ESCs_Mouse1.23297904
77ELK4_26923725_Chip-Seq_MESODERM_Mouse1.23193257
78STAT3_18555785_Chip-Seq_ESCs_Mouse1.22794698
79NANOG_19829295_ChIP-Seq_ESCs_Human1.22472707
80SOX2_19829295_ChIP-Seq_ESCs_Human1.22472707
81TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.22287501
82MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21895805
83NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.21694519
84GATA1_26923725_Chip-Seq_HPCs_Mouse1.21379346
85RUNX1_27457419_Chip-Seq_LIVER_Mouse1.20362748
86KLF5_20875108_ChIP-Seq_MESCs_Mouse1.19138999
87FOXA1_21572438_ChIP-Seq_LNCaP_Human1.18222719
88SOX2_21211035_ChIP-Seq_LN229_Gbm1.15879110
89NMYC_18555785_Chip-Seq_ESCs_Mouse1.14852845
90P300_19829295_ChIP-Seq_ESCs_Human1.14703923
91HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.14674545
92STAT1_17558387_ChIP-Seq_HELA_Human1.14633225
93CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.14487091
94MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.14020057
95ZFX_18555785_Chip-Seq_ESCs_Mouse1.12135239
96FLI1_21867929_ChIP-Seq_TH2_Mouse1.12087422
97SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11844203
98ESRRB_18555785_Chip-Seq_ESCs_Mouse1.11710095
99TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11484017
100SMAD4_21799915_ChIP-Seq_A2780_Human1.11457524
101SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.11051757
102SMAD3_21741376_ChIP-Seq_EPCs_Human1.10522231
103BMI1_23680149_ChIP-Seq_NPCS_Mouse1.10252729
104UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09521382
105PU1_27457419_Chip-Seq_LIVER_Mouse1.09050764
106ARNT_22903824_ChIP-Seq_MCF-7_Human1.08748512
107CDX2_22108803_ChIP-Seq_LS180_Human1.08742179
108CTCF_18555785_Chip-Seq_ESCs_Mouse1.07217610
109TP53_16413492_ChIP-PET_HCT116_Human1.07208700
110SMAD1_18555785_Chip-Seq_ESCs_Mouse1.07082731
111CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.05854066
112OCT4_21477851_ChIP-Seq_ESCs_Mouse1.04684539
113GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.04643117
114SOX9_26525672_Chip-Seq_HEART_Mouse1.02950288
115TCF4_23295773_ChIP-Seq_U87_Human1.02903341
116FOXA1_27270436_Chip-Seq_PROSTATE_Human1.02680981
117FOXA1_25329375_ChIP-Seq_VCAP_Human1.02680981
118KAP1_22055183_ChIP-Seq_ESCs_Mouse1.02635073
119WDR5_24793694_ChIP-Seq_LNCAP_Human1.01701577
120SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.00947560
121TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99663882
122DROSHA_22980978_ChIP-Seq_HELA_Human0.99142916
123RBPJ_22232070_ChIP-Seq_NCS_Mouse0.99123751
124AHR_22903824_ChIP-Seq_MCF-7_Human0.98907648
125SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97989623
126AR_20517297_ChIP-Seq_VCAP_Human0.96966101
127SMAD_19615063_ChIP-ChIP_OVARY_Human0.96852120
128SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.94970466
129ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.94014791
130SOX2_22085726_ChIP-Seq_NPCs_Mouse0.92795963
131AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92742837
132CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91923853
133STAT6_21828071_ChIP-Seq_BEAS2B_Human0.89288997
134* GATA3_21867929_ChIP-Seq_CD8_Mouse0.88408983
135* TP53_22573176_ChIP-Seq_HFKS_Human0.87783465
136SUZ12_27294783_Chip-Seq_ESCs_Mouse0.86915338
137SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.85844069
138TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.85701855

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive4.59400036
2MP0008877_abnormal_DNA_methylation4.14885450
3MP0001929_abnormal_gametogenesis4.08790266
4MP0009379_abnormal_foot_pigmentation3.88928950
5MP0003880_abnormal_central_pattern3.80822138
6MP0000569_abnormal_digit_pigmentation3.30614490
7MP0003195_calcinosis2.94157775
8MP0002210_abnormal_sex_determination2.74962104
9MP0002161_abnormal_fertility/fecundity2.39397326
10MP0001145_abnormal_male_reproductive2.29677437
11MP0002837_dystrophic_cardiac_calcinosis2.22339695
12MP0008057_abnormal_DNA_replication2.21768857
13MP0005645_abnormal_hypothalamus_physiol2.01610783
14MP0005410_abnormal_fertilization11.5610264
15MP0009046_muscle_twitch1.99596206
16MP0000653_abnormal_sex_gland1.98481348
17MP0001188_hyperpigmentation1.87752013
18MP0003787_abnormal_imprinting1.81911220
19MP0002736_abnormal_nociception_after1.73556920
20MP0008872_abnormal_physiological_respon1.69345753
21MP0001968_abnormal_touch/_nociception1.69107685
22MP0002653_abnormal_ependyma_morphology1.66922996
23MP0002160_abnormal_reproductive_system1.63137018
24MP0000427_abnormal_hair_cycle1.61023384
25MP0009745_abnormal_behavioral_response1.60682735
26MP0006276_abnormal_autonomic_nervous1.58758861
27MP0005084_abnormal_gallbladder_morpholo1.57904513
28MP0001529_abnormal_vocalization1.56738673
29MP0003635_abnormal_synaptic_transmissio1.55021276
30MP0005623_abnormal_meninges_morphology1.46504625
31MP0002064_seizures1.46266752
32MP0001984_abnormal_olfaction1.44363496
33MP0002272_abnormal_nervous_system1.42442761
34MP0004147_increased_porphyrin_level1.41804921
35MP0002572_abnormal_emotion/affect_behav1.39023981
36MP0002928_abnormal_bile_duct1.38840949
37MP0003878_abnormal_ear_physiology1.38386750
38MP0005377_hearing/vestibular/ear_phenot1.38386750
39MP0010386_abnormal_urinary_bladder1.37954518
40MP0006292_abnormal_olfactory_placode1.36527190
41MP0001486_abnormal_startle_reflex1.35267891
42MP0004859_abnormal_synaptic_plasticity1.32127518
43MP0002876_abnormal_thyroid_physiology1.29412602
44MP0001986_abnormal_taste_sensitivity1.27316283
45MP0004270_analgesia1.25544896
46MP0005409_darkened_coat_color1.23140967
47MP0001905_abnormal_dopamine_level1.22733601
48MP0002734_abnormal_mechanical_nocicepti1.20540839
49MP0000778_abnormal_nervous_system1.19535045
50MP0002063_abnormal_learning/memory/cond1.19404836
51MP0005551_abnormal_eye_electrophysiolog1.18647496
52MP0003136_yellow_coat_color1.14881691
53MP0002067_abnormal_sensory_capabilities1.11485230
54MP0003121_genomic_imprinting1.10751058
55MP0001765_abnormal_ion_homeostasis1.10039135
56MP0002735_abnormal_chemical_nociception1.09597912
57MP0003718_maternal_effect1.09099717
58MP0004133_heterotaxia1.06415786
59MP0003011_delayed_dark_adaptation1.06253514
60MP0001440_abnormal_grooming_behavior1.05001247
61MP0003646_muscle_fatigue1.03822418
62MP0005085_abnormal_gallbladder_physiolo1.03171235
63MP0005423_abnormal_somatic_nervous1.03071635
64MP0000015_abnormal_ear_pigmentation1.02875235
65MP0004142_abnormal_muscle_tone1.02768227
66MP0005386_behavior/neurological_phenoty1.02114791
67MP0003122_maternal_imprinting0.99415805
68MP0008875_abnormal_xenobiotic_pharmacok0.99351971
69MP0003329_amyloid_beta_deposits0.95948426
70MP0002938_white_spotting0.95184883
71MP0002138_abnormal_hepatobiliary_system0.95064152
72MP0002282_abnormal_trachea_morphology0.94806581
73MP0004215_abnormal_myocardial_fiber0.94619950
74MP0004145_abnormal_muscle_electrophysio0.94412683
75MP0009780_abnormal_chondrocyte_physiolo0.94359835
76MP0004742_abnormal_vestibular_system0.94354223
77MP0006054_spinal_hemorrhage0.94251805
78MP0000230_abnormal_systemic_arterial0.93886398
79MP0008789_abnormal_olfactory_epithelium0.93694596
80MP0005167_abnormal_blood-brain_barrier0.93210767
81MP0002557_abnormal_social/conspecific_i0.92745404
82MP0002909_abnormal_adrenal_gland0.92453669
83MP0002102_abnormal_ear_morphology0.90831180
84MP0002095_abnormal_skin_pigmentation0.88686236
85MP0000383_abnormal_hair_follicle0.88678627
86MP0002234_abnormal_pharynx_morphology0.88498002
87MP0003890_abnormal_embryonic-extraembry0.87807109
88MP0002163_abnormal_gland_morphology0.84801257
89MP0000647_abnormal_sebaceous_gland0.84779299
90MP0006072_abnormal_retinal_apoptosis0.82678125
91MP0005389_reproductive_system_phenotype0.81608227
92MP0005220_abnormal_exocrine_pancreas0.80566652
93MP0000920_abnormal_myelination0.80085289
94MP0000516_abnormal_urinary_system0.79983442
95MP0005367_renal/urinary_system_phenotyp0.79983442
96MP0000538_abnormal_urinary_bladder0.79264962
97MP0004885_abnormal_endolymph0.79161491
98MP0001963_abnormal_hearing_physiology0.78450988
99MP0004085_abnormal_heartbeat0.78229557
100MP0000566_synostosis0.77178825
101MP0000462_abnormal_digestive_system0.75357890
102MP0004233_abnormal_muscle_weight0.74938693
103MP0002882_abnormal_neuron_morphology0.73111372
104MP0001501_abnormal_sleep_pattern0.71662567
105MP0005171_absent_coat_pigmentation0.71407099
106MP0001970_abnormal_pain_threshold0.71200870
107MP0000026_abnormal_inner_ear0.70803562
108MP0005253_abnormal_eye_physiology0.70692352
109MP0002229_neurodegeneration0.70499537
110MP0005646_abnormal_pituitary_gland0.70208200
111MP0002752_abnormal_somatic_nervous0.69587725
112MP0001485_abnormal_pinna_reflex0.68355802
113MP0002066_abnormal_motor_capabilities/c0.67021116
114MP0005379_endocrine/exocrine_gland_phen0.66760088
115MP0002152_abnormal_brain_morphology0.66096677
116MP0000955_abnormal_spinal_cord0.64568103
117MP0003786_premature_aging0.60998531
118MP0008569_lethality_at_weaning0.60821507
119MP0009250_abnormal_appendicular_skeleto0.60503687
120MP0005636_abnormal_mineral_homeostasis0.59472642
121MP0002822_catalepsy0.59298502
122MP0003123_paternal_imprinting0.58119155
123MP0001348_abnormal_lacrimal_gland0.58083931
124MP0003879_abnormal_hair_cell0.56343581
125MP0008058_abnormal_DNA_repair0.56259154
126MP0001324_abnormal_eye_pigmentation0.56088878
127MP0002733_abnormal_thermal_nociception0.55392249
128MP0006036_abnormal_mitochondrial_physio0.54543648
129MP0008995_early_reproductive_senescence0.54540052
130MP0002184_abnormal_innervation0.53988665
131MP0003315_abnormal_perineum_morphology0.53163550
132MP0002638_abnormal_pupillary_reflex0.52279827
133MP0000631_abnormal_neuroendocrine_gland0.52224820
134MP0005195_abnormal_posterior_eye0.51964000
135MP0005174_abnormal_tail_pigmentation0.51031386
136MP0003633_abnormal_nervous_system0.50756945
137MP0004811_abnormal_neuron_physiology0.50291680
138MP0003861_abnormal_nervous_system0.49444766
139MP0004043_abnormal_pH_regulation0.49280352
140MP0003938_abnormal_ear_development0.48800157
141MP0003631_nervous_system_phenotype0.48755235
142MP0004924_abnormal_behavior0.47898724

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)8.72639181
2Abnormal respiratory motile cilium morphology (HP:0005938)8.65313975
3Abnormal respiratory epithelium morphology (HP:0012253)8.65313975
4Abnormal ciliary motility (HP:0012262)7.59206703
5Rhinitis (HP:0012384)6.82790180
6Chronic bronchitis (HP:0004469)5.88527536
7Infertility (HP:0000789)5.27827856
8Nasal polyposis (HP:0100582)4.21195665
9Nephronophthisis (HP:0000090)3.94858947
10Chronic hepatic failure (HP:0100626)3.79332866
11Bronchiectasis (HP:0002110)3.71517540
12Congenital stationary night blindness (HP:0007642)3.66315410
13Attenuation of retinal blood vessels (HP:0007843)3.48138350
14Progressive cerebellar ataxia (HP:0002073)3.44266214
15Medial flaring of the eyebrow (HP:0010747)3.33041281
16Bony spicule pigmentary retinopathy (HP:0007737)3.32682970
17Tubulointerstitial nephritis (HP:0001970)3.32278583
18Abnormality of the nasal mucosa (HP:0000433)3.31819897
19Abnormality of the renal cortex (HP:0011035)3.25002115
20Bronchitis (HP:0012387)3.23983392
21Genetic anticipation (HP:0003743)3.10960015
22Abnormality of the renal medulla (HP:0100957)2.99582369
23Recurrent sinusitis (HP:0011108)2.90325846
24Cystic liver disease (HP:0006706)2.86176106
25Fair hair (HP:0002286)2.83034246
26Abolished electroretinogram (ERG) (HP:0000550)2.78883667
27Renal cortical cysts (HP:0000803)2.77250614
28Molar tooth sign on MRI (HP:0002419)2.76266853
29Abnormality of midbrain morphology (HP:0002418)2.76266853
30Abnormal biliary tract physiology (HP:0012439)2.67398705
31Bile duct proliferation (HP:0001408)2.67398705
32Febrile seizures (HP:0002373)2.63244198
33Hemiparesis (HP:0001269)2.50895700
34Abnormal spermatogenesis (HP:0008669)2.47787925
35Pendular nystagmus (HP:0012043)2.44422725
36Male infertility (HP:0003251)2.36928405
37Protruding tongue (HP:0010808)2.35779447
38Broad-based gait (HP:0002136)2.33810997
39Acute necrotizing encephalopathy (HP:0006965)2.30290910
40Focal motor seizures (HP:0011153)2.29814414
41Clumsiness (HP:0002312)2.28513302
42Gait imbalance (HP:0002141)2.28108741
43Congenital primary aphakia (HP:0007707)2.22613896
44Retinal dysplasia (HP:0007973)2.21137012
45Recurrent otitis media (HP:0000403)2.19682062
46Furrowed tongue (HP:0000221)2.19495402
47Dialeptic seizures (HP:0011146)2.19211753
48Microglossia (HP:0000171)2.18083838
49Generalized hypopigmentation of hair (HP:0011358)2.17467150
50Inability to walk (HP:0002540)2.16673040
51Tubulointerstitial abnormality (HP:0001969)2.15543521
52Keratoconus (HP:0000563)2.12924036
53Increased corneal curvature (HP:0100692)2.12924036
54Abnormal rod and cone electroretinograms (HP:0008323)2.11732684
55Aplasia/Hypoplasia of the tibia (HP:0005772)2.09149467
56Progressive macrocephaly (HP:0004481)2.08410236
57Abnormal protein N-linked glycosylation (HP:0012347)2.07916447
58Abnormal protein glycosylation (HP:0012346)2.07916447
59Abnormal glycosylation (HP:0012345)2.07916447
60Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.07916447
61Progressive inability to walk (HP:0002505)2.03687820
62Dyskinesia (HP:0100660)2.03503626
63Decreased circulating renin level (HP:0003351)2.03486283
64Mitochondrial inheritance (HP:0001427)2.01038091
65Dynein arm defect of respiratory motile cilia (HP:0012255)11.8884296
66Absent/shortened dynein arms (HP:0200106)11.8884296
67Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.8295178
68Gonadotropin excess (HP:0000837)1.99608480
69Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.99287627
70Abnormality of alanine metabolism (HP:0010916)1.99287627
71Hyperalaninemia (HP:0003348)1.99287627
72Abnormality of renal resorption (HP:0011038)1.99203087
73Retinitis pigmentosa (HP:0000510)1.98955976
74Abnormality of DNA repair (HP:0003254)1.97401146
75Methylmalonic acidemia (HP:0002912)1.96937773
76Abnormal mitochondria in muscle tissue (HP:0008316)1.96537589
77Male pseudohermaphroditism (HP:0000037)1.94593490
78Postaxial foot polydactyly (HP:0001830)1.94218790
79Optic disc pallor (HP:0000543)1.93990616
80Ketoacidosis (HP:0001993)1.92710752
81Occipital encephalocele (HP:0002085)1.92709802
82Hyperglycinemia (HP:0002154)1.91529716
83Widely spaced teeth (HP:0000687)1.91094834
84Hypoplasia of the pons (HP:0012110)1.90247572
85Hyperglycinuria (HP:0003108)1.90238883
86Intestinal atresia (HP:0011100)1.90068544
87Nephrogenic diabetes insipidus (HP:0009806)1.90059802
88Lissencephaly (HP:0001339)1.89462281
89Sensory axonal neuropathy (HP:0003390)1.88799457
90Constricted visual fields (HP:0001133)1.88251068
91Bulbous nose (HP:0000414)1.87244988
92Abnormality of the pons (HP:0007361)1.86649049
93Impaired proprioception (HP:0010831)1.84567561
94Degeneration of the lateral corticospinal tracts (HP:0002314)1.83977940
95Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.83977940
96Stage 5 chronic kidney disease (HP:0003774)1.83878465
97Pancreatic fibrosis (HP:0100732)1.83189177
98Chorioretinal atrophy (HP:0000533)1.81884554
99Aplasia/Hypoplasia of the lens (HP:0008063)1.81804667
100Amyotrophic lateral sclerosis (HP:0007354)1.80669782
101Tubular atrophy (HP:0000092)1.79949863
102Polyuria (HP:0000103)1.79729189
103Hyperventilation (HP:0002883)1.78591559
104Supernumerary spleens (HP:0009799)1.78390192
105Aplasia/Hypoplasia of the tongue (HP:0010295)1.76642868
106Methylmalonic aciduria (HP:0012120)1.75283660
107Genital tract atresia (HP:0001827)1.73951947
108Acute encephalopathy (HP:0006846)1.73768634
109Abnormality of macular pigmentation (HP:0008002)1.73709431
110Type I transferrin isoform profile (HP:0003642)1.73652917
111Oculomotor apraxia (HP:0000657)1.72407155
112Azoospermia (HP:0000027)1.71890397
113Short foot (HP:0001773)1.71722944
114Thyroid-stimulating hormone excess (HP:0002925)1.71412231
115Vaginal atresia (HP:0000148)1.70849994
116Dyschromatopsia (HP:0007641)1.70197539
117Epileptic encephalopathy (HP:0200134)1.66094920
118Increased CSF lactate (HP:0002490)1.64476483
119Hepatocellular necrosis (HP:0001404)1.63213319
120Congenital hepatic fibrosis (HP:0002612)1.62966971
121Postaxial hand polydactyly (HP:0001162)1.62839668
122Congenital malformation of the right heart (HP:0011723)1.60952307
123Double outlet right ventricle (HP:0001719)1.60952307
124Delayed gross motor development (HP:0002194)1.60226645
125True hermaphroditism (HP:0010459)1.60074066
126Neurofibrillary tangles (HP:0002185)1.53129540
127Fibular hypoplasia (HP:0003038)1.52711457
128Hypoplasia of the capital femoral epiphysis (HP:0003090)1.51905888
129Gaze-evoked nystagmus (HP:0000640)1.51497420
130Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.51368395
131Congenital sensorineural hearing impairment (HP:0008527)1.50945098
132Polydipsia (HP:0001959)1.49315787
133Abnormal drinking behavior (HP:0030082)1.49315787
134Increased serum pyruvate (HP:0003542)1.48211554
135Abnormality of glycolysis (HP:0004366)1.48211554
136Recurrent bronchitis (HP:0002837)1.47620629
137Decreased central vision (HP:0007663)1.47046577
138Poor coordination (HP:0002370)1.47000735
139Increased hepatocellular lipid droplets (HP:0006565)1.46795393
140Impulsivity (HP:0100710)1.46639782
141Anencephaly (HP:0002323)1.45129753
142Type II lissencephaly (HP:0007260)1.43298295
143Sclerocornea (HP:0000647)1.41041968
144Absent speech (HP:0001344)1.40904095
145Aplasia/Hypoplasia of the sacrum (HP:0008517)1.40571858
146Optic nerve hypoplasia (HP:0000609)1.39430321
147Cerebellar dysplasia (HP:0007033)1.39290172
148Abnormality of the lower motor neuron (HP:0002366)1.37744891
149J-shaped sella turcica (HP:0002680)1.37364250
150Pancreatic cysts (HP:0001737)1.36276905
151Chronic sinusitis (HP:0011109)1.35285476
152Median cleft lip (HP:0000161)1.35269462
153Atonic seizures (HP:0010819)1.34436735
154Abnormality of molar (HP:0011077)1.34083197
155Abnormality of molar morphology (HP:0011070)1.34083197
156Taurodontia (HP:0000679)1.33975648
157Abnormality of permanent molar morphology (HP:0011071)1.33975648
158Abnormality of the dental root (HP:0006486)1.33975648
159Focal seizures (HP:0007359)1.33919888

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK7.26647302
2PDK37.20482843
3PDK47.20482843
4PDK24.44528378
5STK393.76763483
6TESK13.06057800
7PNCK2.90210794
8CASK2.78170210
9WNK42.76533237
10PRKD32.74152712
11ACVR1B2.58205066
12TLK12.27847044
13NUAK12.27698853
14SIK22.04400340
15PTK2B2.03502489
16EIF2AK11.85126700
17MAP4K21.83974208
18INSRR1.82260232
19ICK1.81163014
20MAP2K71.80240343
21DAPK21.78737393
22GRK11.73122550
23ERBB31.42034362
24TRIM281.40235974
25BMPR1B1.39260717
26ZAK1.37844799
27CAMKK21.37605294
28TAOK31.35109890
29STK381.32360763
30WNK11.28265245
31NME11.27230217
32EIF2AK31.24787659
33OXSR11.23489808
34EPHA41.22691084
35BRD41.22526615
36MAP3K41.19912219
37PIK3CG1.10970318
38MKNK21.09204523
39FES1.07039951
40STK161.04694397
41NTRK31.04538882
42IRAK11.03698480
43TESK21.03249215
44CCNB11.01889412
45PAK30.98543779
46CDK190.96930721
47PBK0.95194241
48CSNK1A1L0.89274717
49CSNK1G30.88265557
50CSNK1G10.86778753
51RIPK40.86737695
52IRAK20.83480329
53CSNK1G20.80611253
54TGFBR10.80528884
55PRPF4B0.77797975
56STK30.76496388
57NEK20.74496142
58TNIK0.74154584
59TEC0.74122339
60MINK10.74017768
61PDK10.73997802
62PHKG20.69967631
63PHKG10.69967631
64TNK20.68008836
65CAMK2A0.66708922
66PLK20.65709908
67FER0.64808743
68TAF10.63701354
69GRK70.62901320
70CAMK2B0.62308482
71MUSK0.62014816
72CAMK10.61626240
73DYRK1B0.61479666
74MAP2K60.60734035
75BCR0.60729764
76PRKCG0.60163103
77BRAF0.59655002
78FGFR20.59581105
79LMTK20.59367839
80PINK10.59299670
81CAMK1D0.58134581
82YES10.57465730
83WEE10.56694740
84MAP2K40.56495494
85PIK3CA0.54745397
86KIT0.54695482
87PKN10.53195581
88CAMK1G0.52376235
89BMPR20.51969303
90CSNK1D0.51466814
91BUB10.51060456
92TYRO30.49710435
93BCKDK0.49635982
94STK38L0.49573988
95MAPK150.49563069
96LATS10.49561296
97SRPK10.48116007
98SGK20.47565470
99PRKAA20.47424592
100TXK0.46269831
101CAMK40.45905837
102DYRK20.45675319
103PRKCZ0.45412963
104CDK140.45045755
105MKNK10.44903892
106PRKAA10.44841635
107OBSCN0.44770621
108CHEK20.44232771
109MAP3K120.44195617
110CAMK2D0.44066906
111CSNK1A10.42628282
112VRK10.42034729
113ADRBK20.41547418
114NEK60.40790692
115PDPK10.40443034
116MAPKAPK50.40361766
117CDK120.40185962
118GRK50.40017611
119FLT30.38833518
120CDK30.37029144
121IKBKB0.36871977
122CAMK2G0.36692566
123CDK180.35777012
124PRKCQ0.35505147
125CDK150.35348882
126TTK0.35305087
127SYK0.34976122
128PASK0.34853447
129AKT30.32948621
130BRSK20.32664022
131CDC70.32309567
132MAPK130.31957047
133MARK10.31319566
134MARK20.30698240
135MST40.30669053
136CDK11A0.30375255
137ADRBK10.29912200
138AURKA0.27907581
139UHMK10.26721282
140PRKD20.26662337
141STK110.25981754
142FGR0.25850828
143PAK10.25026713
144CLK10.25007436
145DYRK30.24665778
146NTRK20.22673728
147CDK50.21858799
148PRKACA0.21697513
149WNK30.20273844
150PLK10.19321885
151CSNK2A10.18450043
152ATM0.18066977
153PRKG10.17645420
154PRKCE0.16855887
155DYRK1A0.15787579

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.17252680
2Oxidative phosphorylation_Homo sapiens_hsa001903.61040387
3Huntingtons disease_Homo sapiens_hsa050163.33714014
4Butanoate metabolism_Homo sapiens_hsa006503.02768257
5Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.88117969
6Parkinsons disease_Homo sapiens_hsa050122.80293339
7Pyruvate metabolism_Homo sapiens_hsa006202.74410865
8Basal transcription factors_Homo sapiens_hsa030222.70972948
9Alzheimers disease_Homo sapiens_hsa050102.62455605
10Cardiac muscle contraction_Homo sapiens_hsa042602.56565200
11Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.32580998
12Nicotine addiction_Homo sapiens_hsa050332.27880193
13Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.25022555
14Tryptophan metabolism_Homo sapiens_hsa003802.16541341
15Amphetamine addiction_Homo sapiens_hsa050312.12463836
16Propanoate metabolism_Homo sapiens_hsa006402.12107464
17Collecting duct acid secretion_Homo sapiens_hsa049662.08739538
18ABC transporters_Homo sapiens_hsa020102.05585723
19Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.95644415
20Linoleic acid metabolism_Homo sapiens_hsa005911.95525700
21Nitrogen metabolism_Homo sapiens_hsa009101.94441543
22Fanconi anemia pathway_Homo sapiens_hsa034601.90434586
23Fatty acid biosynthesis_Homo sapiens_hsa000611.81247455
24Primary bile acid biosynthesis_Homo sapiens_hsa001201.78828141
25Long-term potentiation_Homo sapiens_hsa047201.78456605
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.70950591
27Maturity onset diabetes of the young_Homo sapiens_hsa049501.65835747
28Oocyte meiosis_Homo sapiens_hsa041141.65614126
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.64857014
30Renin secretion_Homo sapiens_hsa049241.60769418
31Ether lipid metabolism_Homo sapiens_hsa005651.55690045
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.55418350
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.48866068
34Glucagon signaling pathway_Homo sapiens_hsa049221.47640164
35Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.44823059
36Synaptic vesicle cycle_Homo sapiens_hsa047211.39313976
37Protein export_Homo sapiens_hsa030601.34895169
38Glutamatergic synapse_Homo sapiens_hsa047241.34831274
39Taste transduction_Homo sapiens_hsa047421.34745438
40Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.28077013
41Morphine addiction_Homo sapiens_hsa050321.26850411
42Circadian rhythm_Homo sapiens_hsa047101.26155602
43Steroid hormone biosynthesis_Homo sapiens_hsa001401.23551738
44Pentose phosphate pathway_Homo sapiens_hsa000301.23541584
45Circadian entrainment_Homo sapiens_hsa047131.20157268
46Calcium signaling pathway_Homo sapiens_hsa040201.19319863
47Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.17911595
48Dopaminergic synapse_Homo sapiens_hsa047281.17753653
49Ribosome_Homo sapiens_hsa030101.13473428
50Purine metabolism_Homo sapiens_hsa002301.13110966
51Glycerolipid metabolism_Homo sapiens_hsa005611.11524577
52Retinol metabolism_Homo sapiens_hsa008301.11518011
53Regulation of autophagy_Homo sapiens_hsa041401.10085462
54Chemical carcinogenesis_Homo sapiens_hsa052041.07433030
55Phototransduction_Homo sapiens_hsa047441.07338347
56One carbon pool by folate_Homo sapiens_hsa006701.04152662
57Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.03650373
58Insulin secretion_Homo sapiens_hsa049111.02447313
59Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.02216683
60Dorso-ventral axis formation_Homo sapiens_hsa043201.01279816
61Peroxisome_Homo sapiens_hsa041461.00539331
62Homologous recombination_Homo sapiens_hsa034400.97951003
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97885671
64Salivary secretion_Homo sapiens_hsa049700.97819962
65Caffeine metabolism_Homo sapiens_hsa002320.94310281
66Vibrio cholerae infection_Homo sapiens_hsa051100.93062698
67Lysine degradation_Homo sapiens_hsa003100.92987970
68Glycerophospholipid metabolism_Homo sapiens_hsa005640.91499634
69mRNA surveillance pathway_Homo sapiens_hsa030150.91077831
70Olfactory transduction_Homo sapiens_hsa047400.89552192
71Non-homologous end-joining_Homo sapiens_hsa034500.84835899
72Fatty acid elongation_Homo sapiens_hsa000620.83818650
73Serotonergic synapse_Homo sapiens_hsa047260.83679785
74RNA degradation_Homo sapiens_hsa030180.81326980
75GABAergic synapse_Homo sapiens_hsa047270.79354599
76Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.78881261
77Cysteine and methionine metabolism_Homo sapiens_hsa002700.77351015
78Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.76957790
79Arachidonic acid metabolism_Homo sapiens_hsa005900.76137554
80beta-Alanine metabolism_Homo sapiens_hsa004100.72157650
81Proteasome_Homo sapiens_hsa030500.71859417
82Type II diabetes mellitus_Homo sapiens_hsa049300.70246176
83Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.70159612
84RNA transport_Homo sapiens_hsa030130.69947774
85Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.69884017
86Nucleotide excision repair_Homo sapiens_hsa034200.69617761
87Histidine metabolism_Homo sapiens_hsa003400.68314268
88Long-term depression_Homo sapiens_hsa047300.68147543
89Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.68125977
90Sulfur metabolism_Homo sapiens_hsa009200.68104466
91Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.68039793
92Metabolic pathways_Homo sapiens_hsa011000.67899746
93Sphingolipid metabolism_Homo sapiens_hsa006000.67576098
94Cocaine addiction_Homo sapiens_hsa050300.65103203
95Mineral absorption_Homo sapiens_hsa049780.64023380
96Ovarian steroidogenesis_Homo sapiens_hsa049130.63135565
97Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.61178387
98Axon guidance_Homo sapiens_hsa043600.60965341
99Pentose and glucuronate interconversions_Homo sapiens_hsa000400.60927252
100Gastric acid secretion_Homo sapiens_hsa049710.60578474
101Pancreatic secretion_Homo sapiens_hsa049720.60445049
102Pyrimidine metabolism_Homo sapiens_hsa002400.58639375
103Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57873875
104SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57602134
105Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56966377
106Alcoholism_Homo sapiens_hsa050340.56703939
107Aldosterone synthesis and secretion_Homo sapiens_hsa049250.55417371
108Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.55303826
109Wnt signaling pathway_Homo sapiens_hsa043100.54992185
110Sulfur relay system_Homo sapiens_hsa041220.54925510
111cGMP-PKG signaling pathway_Homo sapiens_hsa040220.54889744
112cAMP signaling pathway_Homo sapiens_hsa040240.54738387
113Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.54376761
114Fatty acid metabolism_Homo sapiens_hsa012120.54248575
115Carbon metabolism_Homo sapiens_hsa012000.50671580
116NOD-like receptor signaling pathway_Homo sapiens_hsa046210.50249649
117Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.49650060
118Fatty acid degradation_Homo sapiens_hsa000710.47345000
119Vascular smooth muscle contraction_Homo sapiens_hsa042700.46327744
120Cholinergic synapse_Homo sapiens_hsa047250.45216168
121Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.44895858
122RNA polymerase_Homo sapiens_hsa030200.44133701
123Glutathione metabolism_Homo sapiens_hsa004800.44105217
124Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41083256
125Systemic lupus erythematosus_Homo sapiens_hsa053220.40698111
126Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40628114
127Spliceosome_Homo sapiens_hsa030400.39432037
128Oxytocin signaling pathway_Homo sapiens_hsa049210.39144300
129Estrogen signaling pathway_Homo sapiens_hsa049150.36972347
130Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35803733
131Selenocompound metabolism_Homo sapiens_hsa004500.35792538
132Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34609287
133Steroid biosynthesis_Homo sapiens_hsa001000.32884705
134Fat digestion and absorption_Homo sapiens_hsa049750.32622912
135Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.32499780
136VEGF signaling pathway_Homo sapiens_hsa043700.30097415
137Hedgehog signaling pathway_Homo sapiens_hsa043400.29927329
138Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.29282645
139Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.29146902
140RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.26386845
141Inositol phosphate metabolism_Homo sapiens_hsa005620.24279885
142Intestinal immune network for IgA production_Homo sapiens_hsa046720.24215395

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