PDZD3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Guanylyl cyclase C (GCC, or GUCY2C; MIM 601330) produces cGMP following the binding of either endogenous ligands or heat-stable enterotoxins secreted by E. coli and other enteric bacteria. Activation of GCC initiates a signaling cascade that leads to phosphorylation of the cystic fibrosis transmembrane conductance regulator (CFTR; MIM 602421), followed by a net efflux of ions and water into the intestinal lumen. IKEPP is a regulatory protein that associates with GCC and regulates the amount of cGMP produced following receptor stimulation (Scott et al., 2002 [PubMed 11950846]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1angiotensin maturation (GO:0002003)9.48485134
2urate metabolic process (GO:0046415)8.64637476
3drug transmembrane transport (GO:0006855)8.22113025
4drug transport (GO:0015893)7.68719331
5regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)7.59272964
6aminoglycoside antibiotic metabolic process (GO:0030647)7.40846848
7intestinal absorption (GO:0050892)6.78052284
8phosphate ion transport (GO:0006817)6.72860086
9modified amino acid transport (GO:0072337)6.60762387
10organic cation transport (GO:0015695)6.49125622
11lysine metabolic process (GO:0006553)6.41664357
12lysine catabolic process (GO:0006554)6.41664357
13fat-soluble vitamin biosynthetic process (GO:0042362)6.20257345
14epoxygenase P450 pathway (GO:0019373)6.12125876
15drug catabolic process (GO:0042737)6.03864574
16phosphate ion transmembrane transport (GO:0035435)5.93902648
17cysteine metabolic process (GO:0006534)5.84756556
18fructose metabolic process (GO:0006000)5.75499987
19exogenous drug catabolic process (GO:0042738)5.65749645
20* regulation of guanylate cyclase activity (GO:0031282)5.56761037
21positive regulation of guanylate cyclase activity (GO:0031284)5.56761037
22NADH metabolic process (GO:0006734)5.47029850
23nonribosomal peptide biosynthetic process (GO:0019184)5.32105773
24quaternary ammonium group transport (GO:0015697)5.30040967
25regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)5.23431226
26endocrine process (GO:0050886)5.23431226
27regulation of systemic arterial blood pressure by hormone (GO:0001990)5.23431226
28lipoprotein transport (GO:0042953)5.08996592
29cellular ketone body metabolic process (GO:0046950)5.08479886
30glutathione biosynthetic process (GO:0006750)5.01159743
31vitamin transport (GO:0051180)4.99074170
32excretion (GO:0007588)4.98051388
33glyoxylate metabolic process (GO:0046487)4.89748493
34renal system process involved in regulation of blood volume (GO:0001977)4.89271994
35diacylglycerol metabolic process (GO:0046339)4.87856661
36folic acid metabolic process (GO:0046655)4.87691391
37renal absorption (GO:0070293)4.84609731
38tricarboxylic acid metabolic process (GO:0072350)4.84131073
39response to mercury ion (GO:0046689)4.80796566
40folic acid transport (GO:0015884)4.80773246
41hormone catabolic process (GO:0042447)4.80750043
42regulation of systemic arterial blood pressure (GO:0003073)4.74845096
43regulation of cellular extravasation (GO:0002691)4.73650878
44homocysteine metabolic process (GO:0050667)4.71482125
45vitamin D metabolic process (GO:0042359)4.62400245
46serine family amino acid metabolic process (GO:0009069)4.60763250
47serine family amino acid catabolic process (GO:0009071)4.60305852
48branched-chain amino acid metabolic process (GO:0009081)4.59679998
49maintenance of gastrointestinal epithelium (GO:0030277)4.59392625
50oligosaccharide catabolic process (GO:0009313)4.47892862
51vitamin transmembrane transport (GO:0035461)4.46983450
52short-chain fatty acid metabolic process (GO:0046459)4.40102265
53ketone body metabolic process (GO:1902224)4.37327362
54bile acid and bile salt transport (GO:0015721)4.35792763
55regulation of bile acid biosynthetic process (GO:0070857)4.35618815
56serine family amino acid biosynthetic process (GO:0009070)4.30405311
57sulfur compound transport (GO:0072348)4.29429958
58very-low-density lipoprotein particle assembly (GO:0034379)4.24268432
59aspartate family amino acid catabolic process (GO:0009068)4.23047948
60cellular glucuronidation (GO:0052695)4.22280773
61regulation of vitamin metabolic process (GO:0030656)4.21680819
62trivalent inorganic anion homeostasis (GO:0072506)4.20014427
63phosphate ion homeostasis (GO:0055062)4.20014427
64positive regulation of pseudopodium assembly (GO:0031274)4.17623589
65branched-chain amino acid catabolic process (GO:0009083)4.16658082
66uronic acid metabolic process (GO:0006063)4.16081268
67glucuronate metabolic process (GO:0019585)4.16081268
68carnitine transport (GO:0015879)4.05922045
69amino-acid betaine transport (GO:0015838)4.05922045
70amino-acid betaine metabolic process (GO:0006577)3.99432361
71urea cycle (GO:0000050)3.95841676
72toxin transport (GO:1901998)3.91659188
73tricarboxylic acid cycle (GO:0006099)3.89329397
74antibacterial humoral response (GO:0019731)3.87575625
75peptide biosynthetic process (GO:0043043)3.87516389
76virion attachment to host cell (GO:0019062)3.86872362
77adhesion of symbiont to host cell (GO:0044650)3.86872362
78peptide hormone processing (GO:0016486)3.85459125
79antimicrobial humoral response (GO:0019730)3.83388074
80regulation of triglyceride catabolic process (GO:0010896)3.83115770
81alditol metabolic process (GO:0019400)3.82922497
82biotin metabolic process (GO:0006768)3.80591591
83valine metabolic process (GO:0006573)3.80417666
84urea metabolic process (GO:0019627)3.78387685
85positive regulation of respiratory burst (GO:0060267)3.77796694
86plasma lipoprotein particle assembly (GO:0034377)3.77296310
87mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.75198467
88regulation of pseudopodium assembly (GO:0031272)3.72747421
89sulfur amino acid catabolic process (GO:0000098)3.72252363
90peptide catabolic process (GO:0043171)3.69977714
912-oxoglutarate metabolic process (GO:0006103)3.69541306
92fatty acid beta-oxidation (GO:0006635)3.67579112
93glycoside metabolic process (GO:0016137)3.67342703
94actin filament depolymerization (GO:0030042)3.64661659
95tryptophan catabolic process (GO:0006569)3.63530431
96indole-containing compound catabolic process (GO:0042436)3.63530431
97indolalkylamine catabolic process (GO:0046218)3.63530431
98flavonoid metabolic process (GO:0009812)3.61717866
99alkaloid metabolic process (GO:0009820)3.60261050
100calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.59691551
101proline metabolic process (GO:0006560)3.59568176
102glutathione derivative biosynthetic process (GO:1901687)3.59205493
103glutathione derivative metabolic process (GO:1901685)3.59205493
104glycosphingolipid catabolic process (GO:0046479)3.58185643
105fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.58175498
106digestion (GO:0007586)3.56212509
107glycolipid catabolic process (GO:0019377)3.56079792
108renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.53359909
109pantothenate metabolic process (GO:0015939)3.51900064
110sulfur amino acid metabolic process (GO:0000096)3.48605696
111nitrogen cycle metabolic process (GO:0071941)3.47998348
112nucleoside diphosphate biosynthetic process (GO:0009133)3.47358747
113glutathione metabolic process (GO:0006749)3.46858963
114digestive system process (GO:0022600)3.46629243
115protein-lipid complex assembly (GO:0065005)3.46382392
116metanephric nephron tubule development (GO:0072234)3.45633896
117metanephric tubule development (GO:0072170)3.45633896
118carnitine metabolic process (GO:0009437)3.44213497
119antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.41521190
120positive regulation of Cdc42 GTPase activity (GO:0043089)3.40475481
121phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.40474430
122fatty acid oxidation (GO:0019395)3.39549210
123response to parathyroid hormone (GO:0071107)3.38237625
124aromatic amino acid family catabolic process (GO:0009074)3.35248461
125positive regulation of lipid catabolic process (GO:0050996)3.35005333
126tryptophan metabolic process (GO:0006568)3.34941315
127antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.34931846
128ethanol oxidation (GO:0006069)3.33889017
129epithelial structure maintenance (GO:0010669)3.33505610
130regulation of cholesterol homeostasis (GO:2000188)3.33052939
131lipid oxidation (GO:0034440)3.31375851
132adhesion of symbiont to host (GO:0044406)3.29537877
133cellular response to nitric oxide (GO:0071732)3.29133957
134cobalamin metabolic process (GO:0009235)3.28700402
135energy coupled proton transport, down electrochemical gradient (GO:0015985)3.27537095
136ATP synthesis coupled proton transport (GO:0015986)3.27537095
137L-phenylalanine metabolic process (GO:0006558)3.27354736
138erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.27354736
139intestinal epithelial cell development (GO:0060576)3.26844519
140polyol transport (GO:0015791)3.25578454
141positive regulation of glycoprotein biosynthetic process (GO:0010560)3.24481579
142acetyl-CoA metabolic process (GO:0006084)3.24453350
143antigen processing and presentation of endogenous antigen (GO:0019883)3.23420719
144transcytosis (GO:0045056)3.20582970
145response to growth hormone (GO:0060416)3.18268133
146positive regulation of fatty acid beta-oxidation (GO:0032000)3.18254554
147polyol catabolic process (GO:0046174)3.16917598
148heme transport (GO:0015886)3.16407732
149positive regulation of cGMP biosynthetic process (GO:0030828)3.16162185
150* regulation of cGMP biosynthetic process (GO:0030826)3.16162185
151leukotriene metabolic process (GO:0006691)3.15549898
152cellular modified amino acid catabolic process (GO:0042219)3.14726635
153glomerular filtration (GO:0003094)3.13815924
154fatty acid catabolic process (GO:0009062)3.12629075
155cellular amino acid catabolic process (GO:0009063)3.12095337
156metanephric nephron epithelium development (GO:0072243)3.12023831
157drug metabolic process (GO:0017144)3.10699106
158cytidine deamination (GO:0009972)3.09287837
159cytidine metabolic process (GO:0046087)3.09287837
160cytidine catabolic process (GO:0006216)3.09287837
161cellular response to reactive nitrogen species (GO:1902170)3.08800967
162response to phenylpropanoid (GO:0080184)3.07660885
163auditory receptor cell differentiation (GO:0042491)3.06999819
164interferon-gamma secretion (GO:0072643)3.05186057
165glycine metabolic process (GO:0006544)3.04319051
166positive regulation of glycoprotein metabolic process (GO:1903020)3.04310527
167lipoprotein metabolic process (GO:0042157)3.04196459
168sexual reproduction (GO:0019953)3.03513130
169glutamine family amino acid biosynthetic process (GO:0009084)3.02594549
170positive regulation of triglyceride lipase activity (GO:0061365)3.02518905
171positive regulation of lipoprotein lipase activity (GO:0051006)3.02518905
172response to nitric oxide (GO:0071731)3.02479372
173glycerol metabolic process (GO:0006071)3.01326190
174sphingomyelin metabolic process (GO:0006684)3.01185568
175sulfate transmembrane transport (GO:1902358)3.00013828
176glycosylceramide metabolic process (GO:0006677)2.97856596
177arginine metabolic process (GO:0006525)2.97503049
178O-glycan processing (GO:0016266)2.95853084
1793-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.95784288
180purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.95784288
181sulfate transport (GO:0008272)2.94595105
182sphingolipid catabolic process (GO:0030149)2.93300269
183phospholipid efflux (GO:0033700)2.93060766
184fat-soluble vitamin metabolic process (GO:0006775)2.91145385
185vitamin A metabolic process (GO:0006776)2.91041520

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.59571817
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.52376122
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.50532121
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.46150466
5AR_21909140_ChIP-Seq_LNCAP_Human3.44209837
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.31545448
7HNF4A_19761587_ChIP-ChIP_CACO-2_Human3.04751140
8PPARA_22158963_ChIP-Seq_LIVER_Mouse2.98716667
9RXR_22158963_ChIP-Seq_LIVER_Mouse2.90894381
10NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.69723284
11CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.62027034
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.51569235
13TP63_17297297_ChIP-ChIP_HaCaT_Human2.48963426
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.47417357
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.45297797
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.38180123
17CDX2_20551321_ChIP-Seq_CACO-2_Human2.34167440
18ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.34090632
19TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.33079799
20STAT3_1855785_ChIP-Seq_MESCs_Mouse2.15434201
21JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.11859377
22KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.06971476
23ZNF263_19887448_ChIP-Seq_K562_Human2.06662479
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.06594985
25ESR1_21235772_ChIP-Seq_MCF-7_Human2.06026852
26ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse2.05252184
27RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.02515475
28SOX2_27498859_Chip-Seq_STOMACH_Mouse2.01946055
29THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.01577302
30NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.96871106
31MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.93842638
32GATA4_25053715_ChIP-Seq_YYC3_Human1.93051216
33LXR_22158963_ChIP-Seq_LIVER_Mouse1.91432023
34NANOG_18555785_ChIP-Seq_MESCs_Mouse1.90687587
35MYC_18555785_ChIP-Seq_MESCs_Mouse1.89918082
36TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.89708813
37ETS1_20019798_ChIP-Seq_JURKAT_Human1.87770667
38STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.85004745
39POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.82499838
40KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.81639632
41ESR2_21235772_ChIP-Seq_MCF-7_Human1.77405725
42* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.70416073
43GATA6_25053715_ChIP-Seq_YYC3_Human1.68583062
44SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.67424382
45FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.64804499
46RACK7_27058665_Chip-Seq_MCF-7_Human1.62950211
47MYC_18358816_ChIP-ChIP_MESCs_Mouse1.61873444
48MYC_19079543_ChIP-ChIP_MESCs_Mouse1.60566348
49CDX2_19796622_ChIP-Seq_MESCs_Mouse1.59912597
50FOXO3_23340844_ChIP-Seq_DLD1_Human1.58791358
51RARG_19884340_ChIP-ChIP_MEFs_Mouse1.55073433
52E2F1_18555785_ChIP-Seq_MESCs_Mouse1.54591623
53NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.48905236
54BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.48383634
55GABP_17652178_ChIP-ChIP_JURKAT_Human1.46947697
56ATF3_27146783_Chip-Seq_COLON_Human1.46797326
57CLOCK_20551151_ChIP-Seq_293T_Human1.46587052
58SRY_22984422_ChIP-ChIP_TESTIS_Rat1.44813760
59CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.44048188
60SOX2_18692474_ChIP-Seq_MEFs_Mouse1.43609814
61BCL6_27268052_Chip-Seq_Bcells_Human1.42957810
62NANOG_18692474_ChIP-Seq_MEFs_Mouse1.42811775
63OCT4_18692474_ChIP-Seq_MEFs_Mouse1.39058322
64TCF3_18692474_ChIP-Seq_MEFs_Mouse1.38853161
65CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.38595293
66GATA1_22025678_ChIP-Seq_K562_Human1.37713572
67CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.35688398
68TRIM28_21343339_ChIP-Seq_HEK293_Human1.35506449
69YY1_21170310_ChIP-Seq_MESCs_Mouse1.35477521
70* BCOR_27268052_Chip-Seq_Bcells_Human1.34937023
71CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.34875817
72SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.34002769
73IRF8_21731497_ChIP-ChIP_J774_Mouse1.30656720
74KLF5_25053715_ChIP-Seq_YYC3_Human1.30502526
75FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.29680211
76EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.28703632
77RUNX1_27514584_Chip-Seq_MCF-7_Human1.28135975
78NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.27045392
79SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.26147952
80VDR_21846776_ChIP-Seq_THP-1_Human1.26035884
81VDR_24763502_ChIP-Seq_THP-1_Human1.26029398
82TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.26018893
83ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.25849768
84CTCF_27219007_Chip-Seq_Bcells_Human1.25059583
85CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23923231
86EST1_17652178_ChIP-ChIP_JURKAT_Human1.23242366
87JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.23221230
88P63_26484246_Chip-Seq_KERATINOCYTES_Human1.23190637
89AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.22637739
90KLF4_18555785_ChIP-Seq_MESCs_Mouse1.21061009
91SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.20102316
92DROSHA_22980978_ChIP-Seq_HELA_Human1.19747083
93BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.17451884
94TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.16170405
95MYC_19030024_ChIP-ChIP_MESCs_Mouse1.15094445
96CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.14611439
97TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.14587319
98PPAR_26484153_Chip-Seq_NCI-H1993_Human1.13591709
99ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12722491
100GATA1_19941826_ChIP-Seq_K562_Human1.11967650
101PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.11794075
102NELFA_20434984_ChIP-Seq_ESCs_Mouse1.11762228
103HNF4A_19822575_ChIP-Seq_HepG2_Human1.11444535
104VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.11356822
105KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.09906155
106SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.08571710
107CREB1_26743006_Chip-Seq_LNCaP_Human1.08420904
108DNAJC2_21179169_ChIP-ChIP_NT2_Human1.08215407
109MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.08056984
110GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.07415248
111TCF4_18268006_ChIP-ChIP_LS174T_Human1.06246527
112GATA2_19941826_ChIP-Seq_K562_Human1.05135930
113ELK3_25401928_ChIP-Seq_HUVEC_Human1.05065525
114CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04927855
115E2F1_20622854_ChIP-Seq_HELA_Human1.04789800
116TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04518726
117EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02099931
118* TET1_21451524_ChIP-Seq_MESCs_Mouse1.02092658
119* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.01989496
120POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01257068
121PHF8_20622854_ChIP-Seq_HELA_Human1.01081271
122CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.00833889
123E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.99936262
124TP63_22573176_ChIP-Seq_HFKS_Human0.99341235
125POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.99248049
126CTCF_27219007_Chip-Seq_ERYTHROID_Human0.97728007
127TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.97538138
128NANOG_20526341_ChIP-Seq_ESCs_Human0.97413381
129PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.97283080
130SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.97212034
131FOXA1_25552417_ChIP-Seq_VCAP_Human0.95932348
132KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.95875781
133LXR_22292898_ChIP-Seq_THP-1_Human0.95311696
134KAP1_22055183_ChIP-Seq_ESCs_Mouse0.95130303
135RAD21_21589869_ChIP-Seq_MESCs_Mouse0.95111146
136EGR1_23403033_ChIP-Seq_LIVER_Mouse0.94981827
137GABP_19822575_ChIP-Seq_HepG2_Human0.94833254
138SRF_21415370_ChIP-Seq_HL-1_Mouse0.94059126
139FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.93899767
140NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.93887381
141FOXA2_19822575_ChIP-Seq_HepG2_Human0.93820839
142NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.93604689
143POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.93313550
144P68_20966046_ChIP-Seq_HELA_Human0.93295465
145ETS1_21867929_ChIP-Seq_TH2_Mouse0.93120324
146* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.93095850
147GATA2_22383799_ChIP-Seq_G1ME_Mouse0.92332449
148SOX17_20123909_ChIP-Seq_XEN_Mouse0.92049869
149SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.90787747
150IKZF1_21737484_ChIP-ChIP_HCT116_Human0.90738159
151GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.90035508
152PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89888959
153VDR_23849224_ChIP-Seq_CD4+_Human0.89721472
154SOX2_20726797_ChIP-Seq_SW620_Human0.89333294
155FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87651927
156CTCF_18555785_ChIP-Seq_MESCs_Mouse0.87292735
157CEBPB_22108803_ChIP-Seq_LS180_Human0.86876801
158XRN2_22483619_ChIP-Seq_HELA_Human0.85638365
159SA1_27219007_Chip-Seq_Bcells_Human0.85501839
160CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.85325104
161TAF2_19829295_ChIP-Seq_ESCs_Human0.85033892
162SOX2_18692474_ChIP-Seq_MESCs_Mouse0.84176865
163NANOG_18692474_ChIP-Seq_MESCs_Mouse0.83983209

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.34611697
2MP0004043_abnormal_pH_regulation5.26397958
3MP0004019_abnormal_vitamin_homeostasis4.93504554
4MP0005377_hearing/vestibular/ear_phenot4.51892918
5MP0003878_abnormal_ear_physiology4.51892918
6MP0005332_abnormal_amino_acid4.27506611
7MP0003183_abnormal_peptide_metabolism3.68452894
8MP0002139_abnormal_hepatobiliary_system3.61249200
9MP0009379_abnormal_foot_pigmentation3.59258652
10MP0009643_abnormal_urine_homeostasis3.58622485
11MP0003195_calcinosis3.13209024
12MP0001765_abnormal_ion_homeostasis3.12535429
13MP0001756_abnormal_urination3.05259389
14MP0008875_abnormal_xenobiotic_pharmacok2.75131288
15MP0005636_abnormal_mineral_homeostasis2.60483355
16MP0002136_abnormal_kidney_physiology2.49566165
17MP0003693_abnormal_embryo_hatching2.36111622
18MP0009840_abnormal_foam_cell2.32995939
19MP0002138_abnormal_hepatobiliary_system2.28295557
20MP0001664_abnormal_digestion2.25849103
21MP0005409_darkened_coat_color2.20093723
22MP0005451_abnormal_body_composition2.11416052
23MP0003806_abnormal_nucleotide_metabolis2.10946027
24MP0004264_abnormal_extraembryonic_tissu2.09227199
25MP0005085_abnormal_gallbladder_physiolo2.06863453
26MP0001666_abnormal_nutrient_absorption2.06290127
27MP0005058_abnormal_lysosome_morphology2.03162183
28MP0005365_abnormal_bile_salt1.91856238
29MP0003868_abnormal_feces_composition1.75101369
30MP0000678_abnormal_parathyroid_gland1.65701322
31MP0004885_abnormal_endolymph1.65548790
32MP0005166_decreased_susceptibility_to1.59460783
33MP0001873_stomach_inflammation1.54624959
34MP0001958_emphysema1.54128264
35MP0003186_abnormal_redox_activity1.53725526
36MP0005084_abnormal_gallbladder_morpholo1.49840081
37MP0003718_maternal_effect1.48624882
38MP0003252_abnormal_bile_duct1.44616874
39MP0004957_abnormal_blastocyst_morpholog1.42725303
40MP0000538_abnormal_urinary_bladder1.39653998
41MP0003191_abnormal_cellular_cholesterol1.37134750
42MP0006036_abnormal_mitochondrial_physio1.34967249
43MP0001188_hyperpigmentation1.33030899
44MP0005319_abnormal_enzyme/_coenzyme1.31220064
45MP0008260_abnormal_autophagy1.30745660
46MP0001764_abnormal_homeostasis1.30036504
47MP0003315_abnormal_perineum_morphology1.28858081
48MP0004858_abnormal_nervous_system1.28492104
49MP0005584_abnormal_enzyme/coenzyme_acti1.24946402
50MP0003646_muscle_fatigue1.24124801
51MP0003724_increased_susceptibility_to1.19298126
52MP0004782_abnormal_surfactant_physiolog1.19041959
53MP0003283_abnormal_digestive_organ1.17658360
54MP0010234_abnormal_vibrissa_follicle1.16341554
55MP0002876_abnormal_thyroid_physiology1.14680651
56MP0002796_impaired_skin_barrier1.13541344
57MP0003303_peritoneal_inflammation1.12469423
58MP0003866_abnormal_defecation1.08231824
59MP0010329_abnormal_lipoprotein_level1.04875302
60MP0004147_increased_porphyrin_level1.02683842
61MP0001661_extended_life_span1.01852933
62MP0003879_abnormal_hair_cell0.99196477
63MP0005395_other_phenotype0.98626825
64MP0003436_decreased_susceptibility_to0.96746993
65MP0002971_abnormal_brown_adipose0.96254100
66MP0001845_abnormal_inflammatory_respons0.95386824
67MP0009785_altered_susceptibility_to0.95095218
68MP0006035_abnormal_mitochondrial_morpho0.94264796
69MP0002089_abnormal_postnatal_growth/wei0.93581250
70MP0000490_abnormal_crypts_of0.93557204
71MP0005448_abnormal_energy_balance0.93364163
72MP0000465_gastrointestinal_hemorrhage0.92069510
73MP0000230_abnormal_systemic_arterial0.90258681
74MP0002118_abnormal_lipid_homeostasis0.89643083
75MP0003941_abnormal_skin_development0.87079842
76MP0004484_altered_response_of0.86856265
77MP0009115_abnormal_fat_cell0.85460765
78MP0003111_abnormal_nucleus_morphology0.83739534
79MP0005025_abnormal_response_to0.83500872
80MP0001730_embryonic_growth_arrest0.81608681
81MP0000537_abnormal_urethra_morphology0.80273916
82MP0000747_muscle_weakness0.80022730
83MP0001485_abnormal_pinna_reflex0.78928351
84MP0002135_abnormal_kidney_morphology0.78483223
85MP0004270_analgesia0.76485055
86MP0000462_abnormal_digestive_system0.76323562
87MP0001727_abnormal_embryo_implantation0.76204050
88MP0008961_abnormal_basal_metabolism0.75321441
89MP0001501_abnormal_sleep_pattern0.75188718
90MP0000477_abnormal_intestine_morphology0.74470724
91MP0001835_abnormal_antigen_presentation0.74181071
92MP0008469_abnormal_protein_level0.73140230
93MP0002166_altered_tumor_susceptibility0.73028075
94MP0005666_abnormal_adipose_tissue0.73007508
95MP0004947_skin_inflammation0.71886188
96MP0000609_abnormal_liver_physiology0.71452957
97MP0006082_CNS_inflammation0.71027025
98MP0005174_abnormal_tail_pigmentation0.70786562
99MP0008004_abnormal_stomach_pH0.69262700
100MP0005501_abnormal_skin_physiology0.69105756
101MP0002822_catalepsy0.67958812
102MP0003300_gastrointestinal_ulcer0.67778666
103MP0002896_abnormal_bone_mineralization0.66322549
104MP0005670_abnormal_white_adipose0.65814037
105MP0000566_synostosis0.65488818
106MP0009642_abnormal_blood_homeostasis0.65049293
107MP0001849_ear_inflammation0.64779901
108MP0002168_other_aberrant_phenotype0.64693240
109MP0001790_abnormal_immune_system0.63722745
110MP0005387_immune_system_phenotype0.63722745
111MP0000249_abnormal_blood_vessel0.62738003
112MP0004084_abnormal_cardiac_muscle0.60637477
113MP0008872_abnormal_physiological_respon0.60450332
114MP0009333_abnormal_splenocyte_physiolog0.59774915
115MP0001663_abnormal_digestive_system0.59281931
116MP0010155_abnormal_intestine_physiology0.59009585
117MP0003638_abnormal_response/metabolism_0.57180192
118MP0002148_abnormal_hypersensitivity_rea0.56920837
119MP0003221_abnormal_cardiomyocyte_apopto0.56845824
120MP0002098_abnormal_vibrissa_morphology0.56387509
121MP0001533_abnormal_skeleton_physiology0.55618377
122MP0005330_cardiomyopathy0.55507871
123MP0005381_digestive/alimentary_phenotyp0.54752031
124MP0000604_amyloidosis0.52017361
125MP0005165_increased_susceptibility_to0.51874698
126MP0009764_decreased_sensitivity_to0.50662217
127MP0001800_abnormal_humoral_immune0.49966848
128MP0005310_abnormal_salivary_gland0.49333313
129MP0000598_abnormal_liver_morphology0.48824126
130MP0005535_abnormal_body_temperature0.48354178
131MP0003329_amyloid_beta_deposits0.47601467
132MP0009672_abnormal_birth_weight0.46207690
133MP0005266_abnormal_metabolism0.44831157
134MP0010352_gastrointestinal_tract_polyps0.44371042
135MP0008932_abnormal_embryonic_tissue0.43677418
136MP0003938_abnormal_ear_development0.43663897
137MP0000358_abnormal_cell_content/0.40810290
138MP0003984_embryonic_growth_retardation0.40458069
139MP0002269_muscular_atrophy0.40154798
140MP0002088_abnormal_embryonic_growth/wei0.39107731
141MP0001216_abnormal_epidermal_layer0.38083121
142MP0005380_embryogenesis_phenotype0.37912427
143MP0001672_abnormal_embryogenesis/_devel0.37912427

Predicted human phenotypes

RankGene SetZ-score
1Metabolic alkalosis (HP:0200114)6.57348574
2Gout (HP:0001997)6.43961940
3Increased circulating renin level (HP:0000848)6.20882116
4Hyperactive renin-angiotensin system (HP:0000841)5.98329314
5Hypokalemic alkalosis (HP:0001949)5.80299452
6Hyperglycinuria (HP:0003108)5.79704551
7Hypomagnesemia (HP:0002917)5.62100467
8Proximal tubulopathy (HP:0000114)5.52430123
9Abnormality of chloride homeostasis (HP:0011422)5.43797524
10Polyuria (HP:0000103)5.26810951
11Abnormality of magnesium homeostasis (HP:0004921)5.06234617
12Abnormal urine output (HP:0012590)5.05766109
13Abnormality of renal excretion (HP:0011036)4.81676370
14Increased purine levels (HP:0004368)4.73324076
15Hyperuricemia (HP:0002149)4.73324076
16Abnormality of glycine metabolism (HP:0010895)4.71677649
17Abnormality of serine family amino acid metabolism (HP:0010894)4.71677649
18Abnormality of glutamine family amino acid metabolism (HP:0010902)4.64166026
19Chronic diarrhea (HP:0002028)4.62913914
20Alkalosis (HP:0001948)4.12803508
21Abnormality of purine metabolism (HP:0004352)4.12163628
22Abnormality of renin-angiotensin system (HP:0000847)4.12082284
23Hyperaldosteronism (HP:0000859)4.03030707
24Glycosuria (HP:0003076)4.00260870
25Abnormality of urine glucose concentration (HP:0011016)4.00260870
26Tetany (HP:0001281)3.93927729
27Renal salt wasting (HP:0000127)3.93140768
28Systemic lupus erythematosus (HP:0002725)3.90734491
29Abnormal drinking behavior (HP:0030082)3.90268243
30Polydipsia (HP:0001959)3.90268243
31Generalized aminoaciduria (HP:0002909)3.78666095
32Hyperglycinemia (HP:0002154)3.70709261
33Fat malabsorption (HP:0002630)3.70707935
34Hypobetalipoproteinemia (HP:0003563)3.68773350
35Hemorrhage of the eye (HP:0011885)3.57511729
36Abdominal distention (HP:0003270)3.40800920
37Hypercalciuria (HP:0002150)3.32967262
38Hyperphosphaturia (HP:0003109)3.28399840
39Wide cranial sutures (HP:0010537)3.27736610
40Congenital sensorineural hearing impairment (HP:0008527)3.26424844
41Abnormality of fatty-acid metabolism (HP:0004359)3.22194043
42Abnormality of monocarboxylic acid metabolism (HP:0010996)3.21818748
43Dicarboxylic aciduria (HP:0003215)3.14631602
44Abnormality of dicarboxylic acid metabolism (HP:0010995)3.14631602
45Hypokalemia (HP:0002900)3.11592599
46Acanthocytosis (HP:0001927)3.09105090
47Ileus (HP:0002595)3.07523928
48Abnormality of nucleobase metabolism (HP:0010932)3.06704790
49Delayed epiphyseal ossification (HP:0002663)3.04405062
50Flat acetabular roof (HP:0003180)2.99884391
51Eczematoid dermatitis (HP:0000976)2.95252984
52Ketoacidosis (HP:0001993)2.92659248
53Abnormal urine phosphate concentration (HP:0012599)2.91992032
54Hydroxyprolinuria (HP:0003080)2.89662409
55Abnormality of proline metabolism (HP:0010907)2.89662409
56Pigmentary retinal degeneration (HP:0001146)2.85180392
57Potter facies (HP:0002009)2.83249924
58Facial shape deformation (HP:0011334)2.83249924
59Lethargy (HP:0001254)2.79745906
60Hyperparathyroidism (HP:0000843)2.73274733
61Renal tubular acidosis (HP:0001947)2.73171680
62Hyperammonemia (HP:0001987)2.72685387
63Nephrolithiasis (HP:0000787)2.71971152
64Malnutrition (HP:0004395)2.71786586
65Abnormality of small intestinal villus morphology (HP:0011472)2.65665995
66Villous atrophy (HP:0011473)2.65665995
67Abnormality of aspartate family amino acid metabolism (HP:0010899)2.64202627
68Megaloblastic anemia (HP:0001889)2.55557983
69Ketosis (HP:0001946)2.54913569
70Methylmalonic aciduria (HP:0012120)2.53377891
71Abnormality of the vitamin B12 metabolism (HP:0004341)2.50121483
72Enlarged epiphyses (HP:0010580)2.48934637
73Hypotension (HP:0002615)2.44387683
74Abnormality of potassium homeostasis (HP:0011042)2.43990070
75Right ventricular cardiomyopathy (HP:0011663)2.43218288
76Dehydration (HP:0001944)2.43161948
77Nausea (HP:0002018)2.42627545
78Focal segmental glomerulosclerosis (HP:0000097)2.42362968
79Vomiting (HP:0002013)2.41068253
80Widely patent fontanelles and sutures (HP:0004492)2.38933863
81Posterior subcapsular cataract (HP:0007787)2.36646763
82Metabolic acidosis (HP:0001942)2.36445775
83Nephrocalcinosis (HP:0000121)2.31004374
84Vacuolated lymphocytes (HP:0001922)2.30004990
85Abnormal tarsal ossification (HP:0008369)2.29263374
86Abnormality of vitamin B metabolism (HP:0004340)2.29089779
87Steatorrhea (HP:0002570)2.28123353
88Abnormality of serum amino acid levels (HP:0003112)2.25731749
89Abnormality of sulfur amino acid metabolism (HP:0004339)2.24040590
90Confusion (HP:0001289)2.23458033
91Hypophosphatemia (HP:0002148)2.20733232
92Vascular calcification (HP:0004934)2.18261018
93Hyponatremia (HP:0002902)2.16555594
94Pustule (HP:0200039)2.15011091
95Pili torti (HP:0003777)2.13699947
96Irritability (HP:0000737)2.13066742
97Protuberant abdomen (HP:0001538)2.12729950
98Rickets (HP:0002748)2.10925863
99Hyperphosphatemia (HP:0002905)2.09959566
100Abnormality of renal resorption (HP:0011038)2.09852124
101Delayed CNS myelination (HP:0002188)2.08141767
102Glomerulonephritis (HP:0000099)2.06950699
103Abnormality of sodium homeostasis (HP:0010931)2.06263650
104Acute encephalopathy (HP:0006846)2.03836493
105Growth hormone excess (HP:0000845)2.02751619
106Gingivitis (HP:0000230)2.02125977
107Metaphyseal cupping (HP:0003021)2.01938304
108Cerebral palsy (HP:0100021)2.01807843
109Subcapsular cataract (HP:0000523)2.01678866
110Abnormal enzyme/coenzyme activity (HP:0012379)1.98857327
111Abnormality of alkaline phosphatase activity (HP:0004379)1.96968556
112Hypolipoproteinemia (HP:0010981)1.94882286
113Petechiae (HP:0000967)1.94229146
114Abnormality of complement system (HP:0005339)1.93851259
115Pancreatitis (HP:0001733)1.91843839
116Abnormality of carpal bone ossification (HP:0006257)1.91187142
117Hepatic necrosis (HP:0002605)1.90503699
118Segmental peripheral demyelination/remyelination (HP:0003481)1.90151663
119Gastrointestinal dysmotility (HP:0002579)1.90146972
120Cardiovascular calcification (HP:0011915)1.88218881
121Renal tubular dysfunction (HP:0000124)1.87135895
122Intrahepatic cholestasis (HP:0001406)1.85121547
123Xanthomatosis (HP:0000991)1.83524087
124Nephritis (HP:0000123)1.82743157
125Abnormality of the costochondral junction (HP:0000919)1.81866946
126Glomerulosclerosis (HP:0000096)1.81734650
127Abnormal hair laboratory examination (HP:0003328)1.80042772
128Conjugated hyperbilirubinemia (HP:0002908)1.79997070
129Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.79938321
130Hypoalbuminemia (HP:0003073)1.79494329
131Abnormal albumin level (HP:0012116)1.79494329
132Hypoglycemic coma (HP:0001325)1.78473251
133Multiple lipomas (HP:0001012)1.77955869
134Complement deficiency (HP:0004431)1.77898107
135Abnormality of the distal phalanges of the toes (HP:0010182)1.77047569
136Carpal bone hypoplasia (HP:0001498)1.76414101
137Bicornuate uterus (HP:0000813)1.75336123
138Decreased circulating renin level (HP:0003351)1.72762883
139Cerebral edema (HP:0002181)1.72127716
140Thin bony cortex (HP:0002753)1.71493602
141Bone pain (HP:0002653)1.71176493
142Abnormality of vitamin metabolism (HP:0100508)1.70555355
143Bilateral sensorineural hearing impairment (HP:0008619)1.68092502
144Chondrocalcinosis (HP:0000934)1.67677659
145Abnormal pancreas size (HP:0012094)1.67045244
146Adrenal overactivity (HP:0002717)1.66252431
147Spastic paraparesis (HP:0002313)1.65115874
148Abnormality of aromatic amino acid family metabolism (HP:0004338)1.63107535

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B6.53866765
2WNK46.41779699
3WNK35.94425082
4OXSR15.27698088
5ERN14.55604831
6EPHA23.64998063
7NEK13.24980137
8BUB13.13251964
9WEE12.88929834
10STK392.87257666
11PDK42.79459642
12PDK32.79459642
13BCKDK2.48393147
14STK38L2.32865899
15MAP3K102.26694982
16PNCK2.25304799
17PDK22.16812988
18EPHB21.82120009
19RIPK41.75338907
20MST1R1.72567796
21MST41.71693987
22MAP4K11.63541108
23TYK21.60332118
24NME21.57135444
25TTK1.56004878
26NME11.52395043
27GRK61.50044701
28MAP2K21.49051876
29PRKCI1.40499760
30MAP3K21.36014465
31STK161.35042693
32PRPF4B1.32231901
33TSSK61.30748181
34EPHA31.23354833
35EIF2AK11.21238240
36MAP3K11.15979430
37SGK4941.15795683
38SGK2231.15795683
39PAK41.15284021
40STK241.07576006
41AKT31.06036956
42TRIB31.06019652
43MAP3K121.03198951
44LMTK20.98182295
45CDC42BPA0.94888561
46PLK40.94483908
47DYRK1B0.91937642
48STK380.89930459
49WNK10.89082700
50EPHA40.87889989
51IRAK30.87167691
52ERBB20.86928155
53MAP3K30.83387287
54NEK20.82834333
55FGFR30.80626371
56FRK0.79862649
57MAP3K110.78806016
58TBK10.77772930
59PIK3CA0.77707384
60BRAF0.74773049
61KSR20.74715464
62CSK0.72367114
63TESK20.70882511
64TNIK0.70783594
65FGFR40.70366654
66EPHB10.67609551
67PRKG20.65913541
68MAP3K80.62920740
69AURKA0.61669875
70BRSK20.61124398
71PINK10.60171741
72PLK10.60069277
73ZAP700.59701064
74AURKB0.59683214
75DDR20.59118777
76ARAF0.59056041
77NLK0.58541538
78MYLK0.58484688
79IRAK40.57097057
80SGK30.56587036
81GSK3A0.56529587
82PDPK10.55741445
83SIK10.54143393
84NEK90.53623090
85PRKAA10.53466886
86LRRK20.52190058
87BLK0.51612886
88IRAK10.49783518
89EIF2AK30.48535306
90RET0.47233575
91SMG10.47092852
92FER0.46860043
93IKBKE0.46450871
94AKT20.46104004
95BMX0.46100098
96MAPK150.46058324
97PAK10.45857640
98SRC0.44834252
99JAK20.43462011
100ABL20.43376845
101DAPK20.42886168
102MAP3K140.42782253
103TAOK10.42278818
104MET0.41323850
105JAK10.40974006
106FYN0.40760380
107PTK20.39431553
108YES10.39312792
109SGK20.38997092
110MATK0.38671233
111PIM10.36712364
112CDK190.36373999
113CSF1R0.36364364
114PDGFRA0.35985302
115RPS6KA20.35964858
116PIM20.35734970
117ZAK0.35062000
118STK100.33123300
119DYRK30.32709158
120LYN0.31848390
121PRKCD0.31386778
122MAP2K60.30703131
123TESK10.30127989
124PAK30.29266759
125JAK30.28960376
126BTK0.28740286
127CHEK20.27339353
128ITK0.27322795
129MAPKAPK20.27160929
130TIE10.26938123
131CSNK1E0.26836972
132PRKCQ0.26142758
133SYK0.26135247
134PRKD20.26016354
135KDR0.22551075
136CDK60.21341010
137MAP2K10.21285911
138MAP3K70.20952280
139PRKCZ0.20837464
140CAMK2G0.20809179
141PLK30.20572321
142RPS6KC10.20000797
143SGK10.19846994
144CAMK2D0.19512615
145PDK10.19343634
146STK110.18461139
147PRKCG0.17754707
148PRKAA20.17392583
149MAPK110.17338221
150PRKCA0.17162541
151CSNK1A10.16901022
152RIPK10.16400624
153MTOR0.15648139
154PTK60.15134729
155CDK40.14552425
156PRKACG0.13897511

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.54916844
2Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006303.21429160
3Butanoate metabolism_Homo sapiens_hsa006503.21380646
4Cyanoamino acid metabolism_Homo sapiens_hsa004603.03662555
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.90118690
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.84686976
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.81545630
8Vitamin digestion and absorption_Homo sapiens_hsa049772.72088417
9Sulfur metabolism_Homo sapiens_hsa009202.55050556
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.52713291
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.52001790
12Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.48501496
13Propanoate metabolism_Homo sapiens_hsa006402.43979956
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.13645207
15Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.11706978
16Fructose and mannose metabolism_Homo sapiens_hsa000512.08348822
17Carbon metabolism_Homo sapiens_hsa012001.99130696
18Mineral absorption_Homo sapiens_hsa049781.97771053
19Fatty acid degradation_Homo sapiens_hsa000711.93616084
20Glutathione metabolism_Homo sapiens_hsa004801.89644515
21Pyruvate metabolism_Homo sapiens_hsa006201.87387366
22Peroxisome_Homo sapiens_hsa041461.84614901
23Folate biosynthesis_Homo sapiens_hsa007901.82627787
24Tryptophan metabolism_Homo sapiens_hsa003801.75890958
25beta-Alanine metabolism_Homo sapiens_hsa004101.74375765
26Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.66069042
27Arginine and proline metabolism_Homo sapiens_hsa003301.55633774
28Collecting duct acid secretion_Homo sapiens_hsa049661.52131030
29Linoleic acid metabolism_Homo sapiens_hsa005911.51332162
30Oxidative phosphorylation_Homo sapiens_hsa001901.51268191
31Bile secretion_Homo sapiens_hsa049761.42811666
32Proteasome_Homo sapiens_hsa030501.39359998
33Renin-angiotensin system_Homo sapiens_hsa046141.38983709
34Pentose phosphate pathway_Homo sapiens_hsa000301.37848364
35Vitamin B6 metabolism_Homo sapiens_hsa007501.36658332
36Fatty acid metabolism_Homo sapiens_hsa012121.29776740
37Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.27298870
38Histidine metabolism_Homo sapiens_hsa003401.24200696
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.22402091
40Glycerolipid metabolism_Homo sapiens_hsa005611.18519196
41Biosynthesis of amino acids_Homo sapiens_hsa012301.18510677
42Parkinsons disease_Homo sapiens_hsa050121.17215536
43Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.16851215
44Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.14493717
45Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.13208613
46Protein digestion and absorption_Homo sapiens_hsa049741.13055569
47Fat digestion and absorption_Homo sapiens_hsa049751.12911206
48Starch and sucrose metabolism_Homo sapiens_hsa005001.10241876
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.09010529
50PPAR signaling pathway_Homo sapiens_hsa033201.06698516
51Asthma_Homo sapiens_hsa053101.06502525
52Drug metabolism - other enzymes_Homo sapiens_hsa009831.06026186
53Regulation of autophagy_Homo sapiens_hsa041401.05963025
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.04892530
55Selenocompound metabolism_Homo sapiens_hsa004501.03424294
56Galactose metabolism_Homo sapiens_hsa000521.02757966
57Intestinal immune network for IgA production_Homo sapiens_hsa046721.02218619
58Other glycan degradation_Homo sapiens_hsa005110.96564423
59Sulfur relay system_Homo sapiens_hsa041220.91968400
60Arginine biosynthesis_Homo sapiens_hsa002200.91005093
61Pancreatic secretion_Homo sapiens_hsa049720.89713922
62Allograft rejection_Homo sapiens_hsa053300.86247399
63Metabolic pathways_Homo sapiens_hsa011000.80946939
64Staphylococcus aureus infection_Homo sapiens_hsa051500.80148707
65Autoimmune thyroid disease_Homo sapiens_hsa053200.79878602
66Ether lipid metabolism_Homo sapiens_hsa005650.78481595
67Graft-versus-host disease_Homo sapiens_hsa053320.76560851
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.74919053
69Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.72841374
70Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.72135981
71Huntingtons disease_Homo sapiens_hsa050160.69449883
72Arachidonic acid metabolism_Homo sapiens_hsa005900.68401481
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66892709
74Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.65873030
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63950267
76Maturity onset diabetes of the young_Homo sapiens_hsa049500.63206313
77Alzheimers disease_Homo sapiens_hsa050100.62045861
78Sphingolipid metabolism_Homo sapiens_hsa006000.58907118
79Phenylalanine metabolism_Homo sapiens_hsa003600.58845962
80Glycerophospholipid metabolism_Homo sapiens_hsa005640.58478707
81Nitrogen metabolism_Homo sapiens_hsa009100.58026275
82Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57489820
83Type I diabetes mellitus_Homo sapiens_hsa049400.55642025
84Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.54942676
85Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54394018
86Fatty acid elongation_Homo sapiens_hsa000620.53771787
87Lysine degradation_Homo sapiens_hsa003100.53546814
88Cardiac muscle contraction_Homo sapiens_hsa042600.53034575
89Lysosome_Homo sapiens_hsa041420.50263894
90Chemical carcinogenesis_Homo sapiens_hsa052040.48828009
91Caffeine metabolism_Homo sapiens_hsa002320.48762672
92RNA polymerase_Homo sapiens_hsa030200.45751317
93Insulin resistance_Homo sapiens_hsa049310.44564190
94Leishmaniasis_Homo sapiens_hsa051400.44369112
95Renin secretion_Homo sapiens_hsa049240.44238146
96Retinol metabolism_Homo sapiens_hsa008300.44066353
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.41904800
98Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.41568878
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.41351833
100Hepatitis C_Homo sapiens_hsa051600.40998849
101Tight junction_Homo sapiens_hsa045300.40772541
102Leukocyte transendothelial migration_Homo sapiens_hsa046700.39017200
103Steroid hormone biosynthesis_Homo sapiens_hsa001400.37110275
104Pyrimidine metabolism_Homo sapiens_hsa002400.36560410
105Antigen processing and presentation_Homo sapiens_hsa046120.36294194
106Tyrosine metabolism_Homo sapiens_hsa003500.33158417
107alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32713261
108Fatty acid biosynthesis_Homo sapiens_hsa000610.29923534
109Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.28995920
110Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.27955280
111Primary bile acid biosynthesis_Homo sapiens_hsa001200.26626319
112Pertussis_Homo sapiens_hsa051330.24625826
113Ribosome_Homo sapiens_hsa030100.19319982
114Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.19307452
115Purine metabolism_Homo sapiens_hsa002300.17698061
116Toxoplasmosis_Homo sapiens_hsa051450.17499362
117Vibrio cholerae infection_Homo sapiens_hsa051100.17247627
118Thyroid hormone synthesis_Homo sapiens_hsa049180.17032473
119Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.16962617
120Viral myocarditis_Homo sapiens_hsa054160.14849794
121Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.14825103
122Cocaine addiction_Homo sapiens_hsa050300.14824490
123Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.14803193
124ABC transporters_Homo sapiens_hsa020100.13968691
125RNA transport_Homo sapiens_hsa030130.13628658
126Glucagon signaling pathway_Homo sapiens_hsa049220.13335707
127Hematopoietic cell lineage_Homo sapiens_hsa046400.13125282
128Steroid biosynthesis_Homo sapiens_hsa001000.12171143
129GnRH signaling pathway_Homo sapiens_hsa049120.12068052
130African trypanosomiasis_Homo sapiens_hsa051430.11706158
131Influenza A_Homo sapiens_hsa051640.11446880
132Tuberculosis_Homo sapiens_hsa051520.10749623
133Insulin secretion_Homo sapiens_hsa049110.10238788
134Glycosaminoglycan degradation_Homo sapiens_hsa005310.07723838
135Chemokine signaling pathway_Homo sapiens_hsa040620.07523593
136TNF signaling pathway_Homo sapiens_hsa046680.07340202
137Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.06845969

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