PDZD11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.52906908
2proteasome assembly (GO:0043248)5.44265142
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.32143881
4ATP synthesis coupled proton transport (GO:0015986)5.32143881
5protein neddylation (GO:0045116)4.97317382
6chaperone-mediated protein transport (GO:0072321)4.90046616
7negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.78749718
8protein deneddylation (GO:0000338)4.52929972
9positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.49158819
10cullin deneddylation (GO:0010388)4.47922709
11regulation of cellular amino acid metabolic process (GO:0006521)4.44158862
12mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.42843176
13termination of RNA polymerase III transcription (GO:0006386)4.40082985
14transcription elongation from RNA polymerase III promoter (GO:0006385)4.40082985
15protein complex biogenesis (GO:0070271)4.35289139
16mitochondrial respiratory chain complex I assembly (GO:0032981)4.34612912
17NADH dehydrogenase complex assembly (GO:0010257)4.34612912
18mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.34612912
19negative regulation of ligase activity (GO:0051352)4.33999191
20negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.33999191
21regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.32304312
22anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.28635837
23antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:4.27643219
24DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.26822096
25L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.22265072
26ribosomal small subunit assembly (GO:0000028)4.21175646
27intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)4.16865671
28signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)4.16865671
29signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)4.14261561
30signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)4.14261561
31signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)4.14261561
327-methylguanosine mRNA capping (GO:0006370)4.10167119
33sequestering of actin monomers (GO:0042989)4.02621559
347-methylguanosine RNA capping (GO:0009452)4.01830186
35RNA capping (GO:0036260)4.01830186
36antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.98022079
37mitochondrial respiratory chain complex assembly (GO:0033108)3.96898174
38signal transduction involved in DNA damage checkpoint (GO:0072422)3.96792545
39signal transduction involved in DNA integrity checkpoint (GO:0072401)3.96792545
40cotranslational protein targeting to membrane (GO:0006613)3.93246557
41signal transduction involved in cell cycle checkpoint (GO:0072395)3.92417947
42ribosomal small subunit biogenesis (GO:0042274)3.91729575
43SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.90105282
44respiratory electron transport chain (GO:0022904)3.89626936
45positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.86742783
46deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.83617607
47protein targeting to ER (GO:0045047)3.83215347
48electron transport chain (GO:0022900)3.82577981
49regulation of mitochondrial translation (GO:0070129)3.76764991
50DNA deamination (GO:0045006)3.75707106
51positive regulation of ligase activity (GO:0051351)3.74585520
52protein localization to endoplasmic reticulum (GO:0070972)3.72133541
53viral transcription (GO:0019083)3.71561399
54platelet dense granule organization (GO:0060155)3.70801887
55protein targeting to mitochondrion (GO:0006626)3.65392737
56translational termination (GO:0006415)3.65108191
57establishment of protein localization to endoplasmic reticulum (GO:0072599)3.60305159
58establishment of protein localization to mitochondrial membrane (GO:0090151)3.60294518
59establishment of protein localization to mitochondrion (GO:0072655)3.50312232
60translation (GO:0006412)3.48729818
61respiratory chain complex IV assembly (GO:0008535)3.44064627
62regulation of cellular amine metabolic process (GO:0033238)3.42697096
63antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)3.41767811
64deoxyribonucleotide biosynthetic process (GO:0009263)3.40676243
65formation of translation preinitiation complex (GO:0001731)3.38986196
662-deoxyribonucleotide biosynthetic process (GO:0009265)3.37654431
67deoxyribose phosphate biosynthetic process (GO:0046385)3.37654431
68L-methionine salvage (GO:0071267)3.33350443
69L-methionine biosynthetic process (GO:0071265)3.33350443
70amino acid salvage (GO:0043102)3.33350443
71hydrogen ion transmembrane transport (GO:1902600)3.33320121
72signal peptide processing (GO:0006465)3.32065664
73regulation of ubiquitin-protein transferase activity (GO:0051438)3.29502512
74maturation of SSU-rRNA (GO:0030490)3.29221054
75ATP biosynthetic process (GO:0006754)3.28750026
76peptidyl-histidine modification (GO:0018202)3.28306354
77nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.23514776
78purine nucleoside triphosphate biosynthetic process (GO:0009145)3.23107045
79GTP biosynthetic process (GO:0006183)3.22560494
80guanosine-containing compound biosynthetic process (GO:1901070)3.22426855
81DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.22238649
82regulation of ligase activity (GO:0051340)3.21880320
83purine nucleobase biosynthetic process (GO:0009113)3.21566894
84protein localization to mitochondrion (GO:0070585)3.21482607
85positive regulation of cell cycle arrest (GO:0071158)3.21413848
86protein-cofactor linkage (GO:0018065)3.21196617
87exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.20003785
88deoxyribonucleoside diphosphate metabolic process (GO:0009186)3.18871455
89purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.17478297
90pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.17053823
91translational elongation (GO:0006414)3.16890188
92mannosylation (GO:0097502)3.15176521
93tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.14097425
94RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.14097425
95translational initiation (GO:0006413)3.12690246
96oxidative phosphorylation (GO:0006119)3.11260869
97ribosomal large subunit biogenesis (GO:0042273)3.10339259
98establishment of viral latency (GO:0019043)3.08200470
99proton transport (GO:0015992)3.07815207
100CENP-A containing nucleosome assembly (GO:0034080)3.07463423
101cytochrome complex assembly (GO:0017004)3.06593691
102cellular protein complex disassembly (GO:0043624)3.06265576
103rRNA modification (GO:0000154)3.05114092
104viral life cycle (GO:0019058)3.04591947
105hydrogen transport (GO:0006818)3.01613620
106GDP-mannose metabolic process (GO:0019673)3.01555795
107cellular component biogenesis (GO:0044085)3.00498453
108establishment of integrated proviral latency (GO:0075713)2.99755173
109pseudouridine synthesis (GO:0001522)2.98809897
110transcription elongation from RNA polymerase II promoter (GO:0006368)2.98673391
111dopamine transport (GO:0015872)2.92941726
112anterograde synaptic vesicle transport (GO:0048490)2.92151144
113inner mitochondrial membrane organization (GO:0007007)2.89618826
114base-excision repair, AP site formation (GO:0006285)2.88018456
115pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.87374648
116negative regulation of protein ubiquitination (GO:0031397)2.86694939
117ribonucleoside triphosphate biosynthetic process (GO:0009201)2.83405524
118DNA damage response, detection of DNA damage (GO:0042769)2.78788691
119protein K11-linked ubiquitination (GO:0070979)2.78677338
120spliceosomal snRNP assembly (GO:0000387)2.74082756
121mitochondrial transport (GO:0006839)2.68644339
122nucleoside triphosphate biosynthetic process (GO:0009142)2.68073237
123protein K6-linked ubiquitination (GO:0085020)2.67350214
124negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.66334882
125protein heterotetramerization (GO:0051290)2.60341726
126intracellular protein transmembrane import (GO:0044743)2.57449340
127intraciliary transport (GO:0042073)2.54545544
128protein maturation by protein folding (GO:0022417)2.54411221

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.53264933
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.97008788
3EST1_17652178_ChIP-ChIP_JURKAT_Human4.33519144
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.29672845
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.07555223
6CREB1_15753290_ChIP-ChIP_HEK293T_Human3.87168577
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.81647464
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.77199743
9MYC_18555785_ChIP-Seq_MESCs_Mouse3.49378128
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.37554781
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.34659957
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.29797199
13CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.21169946
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.04255701
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.90626954
16PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.84118812
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.74853610
18SRF_21415370_ChIP-Seq_HL-1_Mouse2.69675642
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.64536645
20VDR_23849224_ChIP-Seq_CD4+_Human2.61941011
21ELK1_19687146_ChIP-ChIP_HELA_Human2.56715785
22DCP1A_22483619_ChIP-Seq_HELA_Human2.49836002
23MYC_19030024_ChIP-ChIP_MESCs_Mouse2.41375367
24THAP11_20581084_ChIP-Seq_MESCs_Mouse2.40475446
25E2F1_18555785_ChIP-Seq_MESCs_Mouse2.36566334
26XRN2_22483619_ChIP-Seq_HELA_Human2.18475019
27MYC_19079543_ChIP-ChIP_MESCs_Mouse2.16732043
28FOXP3_21729870_ChIP-Seq_TREG_Human2.07435644
29FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.06468523
30RBPJ_22232070_ChIP-Seq_NCS_Mouse2.02573452
31E2F7_22180533_ChIP-Seq_HELA_Human2.02152983
32NELFA_20434984_ChIP-Seq_ESCs_Mouse2.01943008
33E2F4_17652178_ChIP-ChIP_JURKAT_Human2.00077089
34YY1_21170310_ChIP-Seq_MESCs_Mouse1.99024726
35* GABP_19822575_ChIP-Seq_HepG2_Human1.96211082
36TTF2_22483619_ChIP-Seq_HELA_Human1.87437692
37ELK1_22589737_ChIP-Seq_MCF10A_Human1.86804279
38* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.86710774
39NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.81638360
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.81228751
41ZNF274_21170338_ChIP-Seq_K562_Hela1.80910966
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64872798
43ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.64019604
44TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.61587940
45* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.61585292
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.60581812
47HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.57619352
48GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.54114168
49MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.52526801
50MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.51052798
51YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48726589
52SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.48364987
53PADI4_21655091_ChIP-ChIP_MCF-7_Human1.43808433
54FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.43775905
55TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41820621
56POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.38279184
57MYCN_18555785_ChIP-Seq_MESCs_Mouse1.29521587
58ERG_20887958_ChIP-Seq_HPC-7_Mouse1.27682402
59ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.26189789
60NANOG_18555785_ChIP-Seq_MESCs_Mouse1.22230455
61MYC_18940864_ChIP-ChIP_HL60_Human1.18575070
62CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.16896648
63POU3F2_20337985_ChIP-ChIP_501MEL_Human1.15601048
64TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.13952534
65AR_21909140_ChIP-Seq_LNCAP_Human1.12671627
66GBX2_23144817_ChIP-Seq_PC3_Human1.10561688
67P300_19829295_ChIP-Seq_ESCs_Human1.10038186
68POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.07412445
69ZFX_18555785_ChIP-Seq_MESCs_Mouse1.05427124
70FOXM1_23109430_ChIP-Seq_U2OS_Human1.03718249
71TAF15_26573619_Chip-Seq_HEK293_Human1.03584955
72SOX17_20123909_ChIP-Seq_XEN_Mouse1.03325097
73CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.02987125
74CTBP2_25329375_ChIP-Seq_LNCAP_Human1.01739871
75VDR_22108803_ChIP-Seq_LS180_Human1.00943958
76HTT_18923047_ChIP-ChIP_STHdh_Human1.00615458
77BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.00477566
78TP53_22573176_ChIP-Seq_HFKS_Human1.00191072
79CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.99434290
80MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.97273277
81TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.96635440
82SOX2_16153702_ChIP-ChIP_HESCs_Human0.96613663
83CTBP1_25329375_ChIP-Seq_LNCAP_Human0.95136995
84ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.93293320
85KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.91855300
86IRF1_19129219_ChIP-ChIP_H3396_Human0.90937804
87FUS_26573619_Chip-Seq_HEK293_Human0.90775966
88SALL1_21062744_ChIP-ChIP_HESCs_Human0.89871483
89POU5F1_16153702_ChIP-ChIP_HESCs_Human0.89829238
90HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.88996763
91EOMES_21245162_ChIP-Seq_HESCs_Human0.88239372
92SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.86823827
93RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.86423727
94EWS_26573619_Chip-Seq_HEK293_Human0.85092260
95DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.84887664
96SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.82526836
97PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.81349781
98TFEB_21752829_ChIP-Seq_HELA_Human0.80663543
99BMI1_23680149_ChIP-Seq_NPCS_Mouse0.80444548
100SRY_22984422_ChIP-ChIP_TESTIS_Rat0.79373299
101SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.79366553
102GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.78972490
103FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.78293014
104* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77067777
105EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.76917270
106IGF1R_20145208_ChIP-Seq_DFB_Human0.76090579
107CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.75110638
108CTCF_18555785_ChIP-Seq_MESCs_Mouse0.74055543
109HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.73255158
110KDM5A_27292631_Chip-Seq_BREAST_Human0.73145790
111SOX2_18555785_ChIP-Seq_MESCs_Mouse0.72528749
112SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.72392461
113GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.71586003
114CBX2_27304074_Chip-Seq_ESCs_Mouse0.70855706
115E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.69119698
116EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.68055610
117ELF5_23300383_ChIP-Seq_T47D_Human0.67357813
118KAP1_22055183_ChIP-Seq_ESCs_Mouse0.66836577
119PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.65588501
120SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.65581452
121TBX5_21415370_ChIP-Seq_HL-1_Mouse0.64967494
122ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.62255803
123ZFP57_27257070_Chip-Seq_ESCs_Mouse0.61774622
124NANOG_16153702_ChIP-ChIP_HESCs_Human0.61177061
125CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.59037102

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001529_abnormal_vocalization4.19286934
2MP0003693_abnormal_embryo_hatching3.67597938
3MP0001905_abnormal_dopamine_level3.07349910
4MP0000566_synostosis2.91387402
5MP0004957_abnormal_blastocyst_morpholog2.87701492
6MP0003718_maternal_effect2.75668197
7MP0009379_abnormal_foot_pigmentation2.61780324
8MP0002163_abnormal_gland_morphology2.51919751
9MP0000372_irregular_coat_pigmentation2.42181037
10MP0003011_delayed_dark_adaptation2.38004884
11MP0005408_hypopigmentation2.29222520
12MP0003186_abnormal_redox_activity2.23228266
13MP0008932_abnormal_embryonic_tissue2.20503288
14MP0003077_abnormal_cell_cycle2.15970244
15MP0001542_abnormal_bone_strength2.15547069
16MP0003123_paternal_imprinting2.12797535
17MP0010386_abnormal_urinary_bladder2.08514206
18MP0002938_white_spotting2.06253205
19MP0006072_abnormal_retinal_apoptosis2.05989094
20MP0010094_abnormal_chromosome_stability2.02088541
21MP0003122_maternal_imprinting1.99697722
22MP0003880_abnormal_central_pattern1.99098648
23MP0006276_abnormal_autonomic_nervous1.89012232
24MP0003950_abnormal_plasma_membrane1.86878168
25MP0008058_abnormal_DNA_repair1.81131888
26MP0002638_abnormal_pupillary_reflex1.77925788
27MP0002837_dystrophic_cardiac_calcinosis1.74726158
28MP0005367_renal/urinary_system_phenotyp1.71104224
29MP0000516_abnormal_urinary_system1.71104224
30MP0006292_abnormal_olfactory_placode1.69314202
31MP0008057_abnormal_DNA_replication1.67404150
32MP0005171_absent_coat_pigmentation1.65866072
33MP0008260_abnormal_autophagy1.65014246
34MP0009697_abnormal_copulation1.59614025
35MP0002876_abnormal_thyroid_physiology1.59131728
36MP0005253_abnormal_eye_physiology1.58759024
37MP0005379_endocrine/exocrine_gland_phen1.58286301
38MP0001986_abnormal_taste_sensitivity1.57588686
39MP0003806_abnormal_nucleotide_metabolis1.55429835
40MP0003786_premature_aging1.53802534
41MP0003111_abnormal_nucleus_morphology1.53292470
42MP0006036_abnormal_mitochondrial_physio1.51950305
43MP0008007_abnormal_cellular_replicative1.51100992
44MP0005551_abnormal_eye_electrophysiolog1.50701242
45MP0002736_abnormal_nociception_after1.47914831
46MP0005451_abnormal_body_composition1.40187903
47MP0008789_abnormal_olfactory_epithelium1.38006841
48MP0002234_abnormal_pharynx_morphology1.36163892
49MP0005503_abnormal_tendon_morphology1.35961866
50MP0005084_abnormal_gallbladder_morpholo1.35842209
51MP0009046_muscle_twitch1.35726051
52MP0003315_abnormal_perineum_morphology1.34234282
53MP0000749_muscle_degeneration1.32996569
54MP0002160_abnormal_reproductive_system1.31659754
55MP0002102_abnormal_ear_morphology1.30980244
56MP0000647_abnormal_sebaceous_gland1.30450075
57MP0003121_genomic_imprinting1.27988252
58MP0002132_abnormal_respiratory_system1.27800453
59MP0006035_abnormal_mitochondrial_morpho1.26803371
60MP0009250_abnormal_appendicular_skeleto1.17501060
61MP0003136_yellow_coat_color1.16910981
62MP0008875_abnormal_xenobiotic_pharmacok1.16896720
63MP0004133_heterotaxia1.16249275
64MP0002148_abnormal_hypersensitivity_rea1.14728173
65MP0002735_abnormal_chemical_nociception1.13434706
66MP0001293_anophthalmia1.10885284
67MP0010030_abnormal_orbit_morphology1.10420665
68MP0009745_abnormal_behavioral_response1.10130390
69MP0004381_abnormal_hair_follicle1.09495332
70MP0001727_abnormal_embryo_implantation1.08439477
71MP0002751_abnormal_autonomic_nervous1.06693230
72MP0002277_abnormal_respiratory_mucosa1.06625813
73MP0005389_reproductive_system_phenotype1.06059867
74MP0009333_abnormal_splenocyte_physiolog1.05701319
75MP0001968_abnormal_touch/_nociception1.04162148
76MP0002090_abnormal_vision1.03868491
77MP0008877_abnormal_DNA_methylation1.02396893
78MP0009780_abnormal_chondrocyte_physiolo1.01002351
79MP0004142_abnormal_muscle_tone1.00367206
80MP0000778_abnormal_nervous_system1.00117828
81MP0000358_abnormal_cell_content/0.99924012
82MP0001188_hyperpigmentation0.99143965
83MP0000569_abnormal_digit_pigmentation0.98653629
84MP0005646_abnormal_pituitary_gland0.98621439
85MP0001299_abnormal_eye_distance/0.93445206
86MP0003755_abnormal_palate_morphology0.92500999
87MP0006054_spinal_hemorrhage0.91128258
88MP0002233_abnormal_nose_morphology0.90325085
89MP0001485_abnormal_pinna_reflex0.89959479
90MP0001346_abnormal_lacrimal_gland0.89033452
91MP0002909_abnormal_adrenal_gland0.87349373
92MP0002095_abnormal_skin_pigmentation0.87213038
93MP0001764_abnormal_homeostasis0.85379395
94MP0005391_vision/eye_phenotype0.85374522
95MP0000026_abnormal_inner_ear0.85181245
96MP0002752_abnormal_somatic_nervous0.84837136
97MP0004147_increased_porphyrin_level0.84437117
98MP0008872_abnormal_physiological_respon0.83897174
99MP0002210_abnormal_sex_determination0.82514166
100MP0000049_abnormal_middle_ear0.82504529
101MP0002184_abnormal_innervation0.82142698
102MP0008004_abnormal_stomach_pH0.81180339
103MP0001324_abnormal_eye_pigmentation0.80635268
104MP0002282_abnormal_trachea_morphology0.80628580
105MP0005195_abnormal_posterior_eye0.80020394
106MP0002572_abnormal_emotion/affect_behav0.79815830
107MP0003183_abnormal_peptide_metabolism0.79793750
108MP0004215_abnormal_myocardial_fiber0.78828208
109MP0002557_abnormal_social/conspecific_i0.78815860
110MP0001486_abnormal_startle_reflex0.78171058
111MP0002734_abnormal_mechanical_nocicepti0.77919252
112MP0003938_abnormal_ear_development0.77000297
113MP0003656_abnormal_erythrocyte_physiolo0.76794250
114MP0003941_abnormal_skin_development0.76704455
115MP0000631_abnormal_neuroendocrine_gland0.76423829
116MP0000462_abnormal_digestive_system0.76397622
117MP0005075_abnormal_melanosome_morpholog0.75483914
118MP0005423_abnormal_somatic_nervous0.75027211
119MP0002295_abnormal_pulmonary_circulatio0.74971119
120MP0005332_abnormal_amino_acid0.74956310
121MP0005499_abnormal_olfactory_system0.74732408
122MP0005394_taste/olfaction_phenotype0.74732408
123MP0002653_abnormal_ependyma_morphology0.73823325
124MP0004134_abnormal_chest_morphology0.72954950
125MP0003195_calcinosis0.71658703
126MP0001963_abnormal_hearing_physiology0.70658810
127MP0001970_abnormal_pain_threshold0.70586345
128MP0004782_abnormal_surfactant_physiolog0.69245202
129MP0000681_abnormal_thyroid_gland0.69032420
130MP0000538_abnormal_urinary_bladder0.67267120
131MP0005636_abnormal_mineral_homeostasis0.65709683
132MP0009785_altered_susceptibility_to0.64845311
133MP0001664_abnormal_digestion0.63401483
134MP0002064_seizures0.61789173
135MP0001984_abnormal_olfaction0.61318074
136MP0002272_abnormal_nervous_system0.59704833
137MP0001919_abnormal_reproductive_system0.59096014
138MP0005508_abnormal_skeleton_morphology0.58674778
139MP0000163_abnormal_cartilage_morphology0.57864042
140MP0002733_abnormal_thermal_nociception0.56160042
141MP0003937_abnormal_limbs/digits/tail_de0.55813134

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.65911953
2Abnormal mitochondria in muscle tissue (HP:0008316)5.08083715
3Mitochondrial inheritance (HP:0001427)4.87549068
4Progressive macrocephaly (HP:0004481)4.51382760
5Hepatocellular necrosis (HP:0001404)4.50433711
6Acute encephalopathy (HP:0006846)4.37814521
7Increased CSF lactate (HP:0002490)4.33054392
8Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.15119417
9Hepatic necrosis (HP:0002605)3.93223492
10Irregular epiphyses (HP:0010582)3.87340495
11Abnormality of cells of the erythroid lineage (HP:0012130)3.78558838
12Abnormality of glycolysis (HP:0004366)3.69214939
13Increased serum pyruvate (HP:0003542)3.69214939
14Increased hepatocellular lipid droplets (HP:0006565)3.56900780
15Abnormal number of erythroid precursors (HP:0012131)3.50060656
16Hypothermia (HP:0002045)3.35686701
17Lipid accumulation in hepatocytes (HP:0006561)3.22921631
18Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.16025793
19Renal Fanconi syndrome (HP:0001994)3.15803867
20Congenital ichthyosiform erythroderma (HP:0007431)3.14233398
21Decreased activity of mitochondrial respiratory chain (HP:0008972)3.13863825
22Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.13863825
23Increased serum lactate (HP:0002151)3.06197672
24Cerebral hypomyelination (HP:0006808)2.99117780
25Exercise intolerance (HP:0003546)2.95461541
26Respiratory failure (HP:0002878)2.94754555
27Rough bone trabeculation (HP:0100670)2.92586359
28Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.90792896
29Type I transferrin isoform profile (HP:0003642)2.86577888
30Parakeratosis (HP:0001036)2.79471935
31Retinal dysplasia (HP:0007973)2.72368562
32Abnormality of midbrain morphology (HP:0002418)2.71457232
33Molar tooth sign on MRI (HP:0002419)2.71457232
343-Methylglutaconic aciduria (HP:0003535)2.66614917
35Optic disc pallor (HP:0000543)2.64701516
36Flat capital femoral epiphysis (HP:0003370)2.63429398
37Lactic acidosis (HP:0003128)2.62388194
38Cerebral edema (HP:0002181)2.55395043
39Leukodystrophy (HP:0002415)2.54998438
40Exertional dyspnea (HP:0002875)2.54739412
41Birth length less than 3rd percentile (HP:0003561)2.52857549
42Methylmalonic acidemia (HP:0002912)2.50762182
43Reticulocytopenia (HP:0001896)2.48628819
44Small epiphyses (HP:0010585)2.47744162
45Respiratory difficulties (HP:0002880)2.43842669
46Macrocytic anemia (HP:0001972)2.43090579
47Absent epiphyses (HP:0010577)2.41460223
48Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.41460223
49Delayed epiphyseal ossification (HP:0002663)2.41395436
50Abnormal trabecular bone morphology (HP:0100671)2.34712378
51Lethargy (HP:0001254)2.34150763
52Increased intramyocellular lipid droplets (HP:0012240)2.31586222
53Carpal bone hypoplasia (HP:0001498)2.29388672
54Aplastic anemia (HP:0001915)2.22919490
55Methylmalonic aciduria (HP:0012120)2.21705493
56Type II lissencephaly (HP:0007260)2.18446367
57Hypoplasia of the capital femoral epiphysis (HP:0003090)2.17886862
58Abnormal hair whorl (HP:0010721)2.16856218
59Sclerocornea (HP:0000647)2.15725778
60Hyperglycinemia (HP:0002154)2.14405253
61Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.13835361
62Abnormal protein N-linked glycosylation (HP:0012347)2.13835361
63Abnormal protein glycosylation (HP:0012346)2.13835361
64Abnormal glycosylation (HP:0012345)2.13835361
65Poor suck (HP:0002033)2.11422920
66Generalized aminoaciduria (HP:0002909)2.11209655
67Secondary amenorrhea (HP:0000869)2.11147589
68Adrenal hypoplasia (HP:0000835)2.08230518
69Abnormality of urine glucose concentration (HP:0011016)2.08046878
70Glycosuria (HP:0003076)2.08046878
71Emotional lability (HP:0000712)2.07804563
72Glossoptosis (HP:0000162)2.03900122
73Genu varum (HP:0002970)2.03614793
74Polyphagia (HP:0002591)2.03361245
75Aplasia/hypoplasia of the uterus (HP:0008684)2.03268014
76Pancreatic fibrosis (HP:0100732)2.02956941
77Aplasia/Hypoplasia of the tongue (HP:0010295)2.02929071
78Short tibia (HP:0005736)2.01061489
79CNS demyelination (HP:0007305)2.00841572
80Microvesicular hepatic steatosis (HP:0001414)2.00507108
81Epiphyseal dysplasia (HP:0002656)2.00320283
82Medial flaring of the eyebrow (HP:0010747)2.00303980
83Hypoplasia of the uterus (HP:0000013)2.00134848
84Delayed gross motor development (HP:0002194)1.99075058
85Breast hypoplasia (HP:0003187)1.98813425
86Abnormality of the anterior horn cell (HP:0006802)1.98511258
87Degeneration of anterior horn cells (HP:0002398)1.98511258
88Type 2 muscle fiber atrophy (HP:0003554)1.97846532
89Pancreatic cysts (HP:0001737)1.97728232
90Bifid tongue (HP:0010297)1.95971321
91Pallor (HP:0000980)1.95407350
92True hermaphroditism (HP:0010459)1.94326122
93Abnormality of renal resorption (HP:0011038)1.93698972
94Neuroendocrine neoplasm (HP:0100634)1.91417602
95Oral leukoplakia (HP:0002745)1.91184897
96Congenital primary aphakia (HP:0007707)1.90017753
97Nephronophthisis (HP:0000090)1.88486099
98Poor head control (HP:0002421)1.87174997
99Abnormality of placental membranes (HP:0011409)1.86723776
100Amniotic constriction ring (HP:0009775)1.86723776
101CNS hypomyelination (HP:0003429)1.86626491
102Abnormality of the labia minora (HP:0012880)1.86357290
103X-linked dominant inheritance (HP:0001423)1.85483700
104Abnormality of methionine metabolism (HP:0010901)1.85372253
105Increased muscle lipid content (HP:0009058)1.85328404
106Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.84226289
107Abnormality of alanine metabolism (HP:0010916)1.84226289
108Hyperalaninemia (HP:0003348)1.84226289
109Muscle fiber atrophy (HP:0100295)1.83275345
110Abnormality of the femoral head (HP:0003368)1.82762243
111Vertebral compression fractures (HP:0002953)1.82487670
112Premature graying of hair (HP:0002216)1.82339498
113Nephrogenic diabetes insipidus (HP:0009806)1.81954379
114Metaphyseal dysplasia (HP:0100255)1.81811807
115Genital tract atresia (HP:0001827)1.81390677
116Hyperphosphaturia (HP:0003109)1.81363715
117Sparse eyelashes (HP:0000653)1.81114229
118Irregular vertebral endplates (HP:0003301)1.80625974
119Autoamputation (HP:0001218)1.80493759
120Hypokinesia (HP:0002375)1.80070329
121Limb dystonia (HP:0002451)1.79433225
122Vaginal atresia (HP:0000148)1.79122887
123Congenital, generalized hypertrichosis (HP:0004540)1.78943958
124Aplasia of the musculature (HP:0100854)1.78914198
125Gait imbalance (HP:0002141)1.78579947
126Reduced antithrombin III activity (HP:0001976)1.78136083
127Median cleft lip (HP:0000161)1.76664462
128Abnormality of the epiphysis of the femoral head (HP:0010574)1.76662851
129Hypoplastic pelvis (HP:0008839)1.76188584
130Blindness (HP:0000618)1.75723167
131Aplasia/Hypoplasia of the tibia (HP:0005772)1.68908230
132Delayed CNS myelination (HP:0002188)1.66426844
133Anencephaly (HP:0002323)1.65462881
134Postaxial hand polydactyly (HP:0001162)1.63584262
135Postaxial foot polydactyly (HP:0001830)1.62334852
136Abnormality of serum amino acid levels (HP:0003112)1.61663863
137Atrophy/Degeneration involving motor neurons (HP:0007373)1.61599316

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.45032286
2STK163.96375034
3VRK23.90307894
4EIF2AK13.20368988
5MAP3K122.68746234
6VRK12.55777311
7WEE12.46343880
8PIM22.39930389
9ARAF2.37393478
10EIF2AK32.32990459
11CCNB12.32069323
12NME22.22823796
13BCKDK2.21547901
14TRIM282.20218624
15MST42.18314152
16CASK2.07549709
17PBK2.06191117
18NME11.97166804
19TSSK61.83696977
20PLK41.78628620
21LIMK11.75435019
22WNK31.74401697
23BRAF1.71943282
24BRSK21.58315995
25TLK11.53159593
26TESK21.48265370
27ADRBK21.46689023
28BCR1.45309166
29MKNK11.42852808
30PLK31.40954961
31MARK11.29193812
32SRPK11.28665381
33PLK21.25222411
34CSNK1G21.23144504
35BMPR21.16507628
36TESK11.16220495
37EPHB21.13668237
38MYLK1.13015975
39BMPR1B1.12810138
40PAK31.11568339
41PDK21.11506875
42GRK11.10591736
43SIK31.09021816
44BRSK11.04930866
45AURKA1.04767993
46CSNK1A1L1.03992287
47ACVR1B1.03544682
48CDK191.02969164
49PLK11.01147734
50DAPK11.00959099
51ZAK1.00937644
52EIF2AK20.99286065
53MKNK20.98222215
54AKT30.98049830
55MAPKAPK50.97897365
56CDC70.97658169
57CDK80.96354642
58STK390.95805861
59ERBB30.95689087
60OXSR10.95629393
61MAP4K20.93692088
62STK240.93378927
63DYRK20.93367571
64YES10.90558075
65DYRK30.87466840
66PHKG20.87257138
67PHKG10.87257138
68MST1R0.83934207
69TAF10.83087806
70AURKB0.81369550
71MAP3K40.79499046
72PNCK0.78254384
73CSNK1G30.78041968
74CAMKK20.75980896
75EPHA20.74857236
76IRAK40.74323617
77MET0.74043262
78PAK60.72704268
79STK38L0.72019313
80INSRR0.71165653
81MAP2K70.69850793
82PASK0.69331575
83PAK40.69160061
84GRK70.68822254
85PRKD30.67717879
86EPHA40.65577939
87CSNK2A10.62773396
88MAPKAPK30.58077366
89CDK30.57666210
90ABL20.57296540
91GRK50.56262848
92CHEK20.55963077
93RPS6KA50.53825416
94TTK0.53539994
95ERBB40.52933170
96MAP3K110.52910234
97NUAK10.51817262
98ADRBK10.51670386
99PRKCI0.50721407
100CAMK2B0.50341962
101PAK10.50314991
102ATR0.49533119
103ILK0.48782449
104CDK140.48765877
105NEK60.48647800
106FRK0.48606632
107CDK180.47333834
108NEK10.47292862
109MOS0.45890228
110CSNK2A20.45504802
111IRAK30.45334820
112DAPK30.42600581
113CAMK2A0.41978348
114BLK0.41652517
115MUSK0.41222146
116WNK40.40409695
117OBSCN0.38394101
118MAP3K30.38241349
119CDK150.37930291
120CDK11A0.37188980
121MAPK130.36266863
122PRKCG0.35894894
123CSNK1G10.35890262
124PRKCE0.33922418
125CAMK2D0.32916093
126UHMK10.32148432
127TNIK0.31111467
128CAMK2G0.30475406
129RPS6KB20.28125332
130IRAK10.28121981
131KIT0.27024982
132MINK10.26362867

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.34625567
2Oxidative phosphorylation_Homo sapiens_hsa001904.19822453
3Ribosome_Homo sapiens_hsa030104.06431856
4RNA polymerase_Homo sapiens_hsa030203.68261657
5Protein export_Homo sapiens_hsa030603.59511522
6Parkinsons disease_Homo sapiens_hsa050123.39744068
7Huntingtons disease_Homo sapiens_hsa050162.54617085
8Alzheimers disease_Homo sapiens_hsa050102.34275211
9DNA replication_Homo sapiens_hsa030302.29594357
10Pyrimidine metabolism_Homo sapiens_hsa002402.20386516
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.18664296
12Collecting duct acid secretion_Homo sapiens_hsa049662.11881685
13Mismatch repair_Homo sapiens_hsa034302.08234513
14Homologous recombination_Homo sapiens_hsa034402.02098960
15Spliceosome_Homo sapiens_hsa030401.91919425
16Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.91853344
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.85773788
18Vibrio cholerae infection_Homo sapiens_hsa051101.79659610
19Basal transcription factors_Homo sapiens_hsa030221.70391801
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.68243555
21Nucleotide excision repair_Homo sapiens_hsa034201.68135448
22Base excision repair_Homo sapiens_hsa034101.64208062
23Propanoate metabolism_Homo sapiens_hsa006401.58863979
24RNA transport_Homo sapiens_hsa030131.53660768
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.40200790
26Purine metabolism_Homo sapiens_hsa002301.40157110
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.36217432
28RNA degradation_Homo sapiens_hsa030181.32059460
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.31654307
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.30045430
31Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.29259192
32Cell cycle_Homo sapiens_hsa041101.25898403
33SNARE interactions in vesicular transport_Homo sapiens_hsa041301.22897304
34Non-homologous end-joining_Homo sapiens_hsa034501.20691624
35Sphingolipid metabolism_Homo sapiens_hsa006001.12753574
36Rheumatoid arthritis_Homo sapiens_hsa053231.11425032
37Butanoate metabolism_Homo sapiens_hsa006501.06926150
38Vitamin B6 metabolism_Homo sapiens_hsa007501.06607908
39Regulation of autophagy_Homo sapiens_hsa041401.06171007
40Fatty acid elongation_Homo sapiens_hsa000621.05568228
41Arachidonic acid metabolism_Homo sapiens_hsa005901.01873108
42Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.00635937
43Peroxisome_Homo sapiens_hsa041460.99352520
44Folate biosynthesis_Homo sapiens_hsa007900.99034757
45Fanconi anemia pathway_Homo sapiens_hsa034600.98270316
46Primary bile acid biosynthesis_Homo sapiens_hsa001200.97099982
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.93384440
48Glutathione metabolism_Homo sapiens_hsa004800.92657452
49Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.92625691
50Steroid biosynthesis_Homo sapiens_hsa001000.92428819
51Cardiac muscle contraction_Homo sapiens_hsa042600.89762654
52Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.88059311
53Phagosome_Homo sapiens_hsa041450.85510136
54Epstein-Barr virus infection_Homo sapiens_hsa051690.84547057
55Sulfur metabolism_Homo sapiens_hsa009200.84523948
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.83297491
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.81973853
58Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.81569922
59Selenocompound metabolism_Homo sapiens_hsa004500.81563116
60Synaptic vesicle cycle_Homo sapiens_hsa047210.77026583
61Metabolic pathways_Homo sapiens_hsa011000.75044219
62p53 signaling pathway_Homo sapiens_hsa041150.74713472
63Ether lipid metabolism_Homo sapiens_hsa005650.69009080
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.68536299
65Tryptophan metabolism_Homo sapiens_hsa003800.66170781
66Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64402520
67Nicotine addiction_Homo sapiens_hsa050330.62672626
68Chemical carcinogenesis_Homo sapiens_hsa052040.62416005
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.62054420
70Caffeine metabolism_Homo sapiens_hsa002320.61596642
71Fatty acid metabolism_Homo sapiens_hsa012120.59550863
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.58804846
73Linoleic acid metabolism_Homo sapiens_hsa005910.57269828
74beta-Alanine metabolism_Homo sapiens_hsa004100.55688446
75Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.53041811
76Legionellosis_Homo sapiens_hsa051340.51551009
77Pentose phosphate pathway_Homo sapiens_hsa000300.47818639
78Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46747769
79Phototransduction_Homo sapiens_hsa047440.43913122
80Type I diabetes mellitus_Homo sapiens_hsa049400.43878452
81Cysteine and methionine metabolism_Homo sapiens_hsa002700.42251631
82Serotonergic synapse_Homo sapiens_hsa047260.42079958
83Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40942023
84Other glycan degradation_Homo sapiens_hsa005110.40891874
85Nitrogen metabolism_Homo sapiens_hsa009100.40401920
86Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.38682197
87N-Glycan biosynthesis_Homo sapiens_hsa005100.38626772
88Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37354347
89Fatty acid degradation_Homo sapiens_hsa000710.36181869
90Mineral absorption_Homo sapiens_hsa049780.35695082
91Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.35605420
92Tyrosine metabolism_Homo sapiens_hsa003500.35274191
93One carbon pool by folate_Homo sapiens_hsa006700.32957388
94Oocyte meiosis_Homo sapiens_hsa041140.32035450
95Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.32020758
96Pyruvate metabolism_Homo sapiens_hsa006200.31454089
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31296734
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30300618
99Maturity onset diabetes of the young_Homo sapiens_hsa049500.30196818
100Allograft rejection_Homo sapiens_hsa053300.28922873
101Arginine and proline metabolism_Homo sapiens_hsa003300.28588094
102Retinol metabolism_Homo sapiens_hsa008300.28489020
103Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.28106546
104Circadian rhythm_Homo sapiens_hsa047100.28052624
105Alcoholism_Homo sapiens_hsa050340.25832495
106Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.25723785
107Asthma_Homo sapiens_hsa053100.25116393
108Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.24930417
109Basal cell carcinoma_Homo sapiens_hsa052170.24714552
110Lysosome_Homo sapiens_hsa041420.24357278
111Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23875241
112Galactose metabolism_Homo sapiens_hsa000520.23543180
113Steroid hormone biosynthesis_Homo sapiens_hsa001400.23292234
114Sulfur relay system_Homo sapiens_hsa041220.23178353
115Fructose and mannose metabolism_Homo sapiens_hsa000510.23132653
116Autoimmune thyroid disease_Homo sapiens_hsa053200.22586600
117Phenylalanine metabolism_Homo sapiens_hsa003600.22179228
118Cyanoamino acid metabolism_Homo sapiens_hsa004600.17319696
119Malaria_Homo sapiens_hsa051440.16871309
120Renin-angiotensin system_Homo sapiens_hsa046140.16340994
121Systemic lupus erythematosus_Homo sapiens_hsa053220.15893100
122Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.14968995
123Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.12927680
124Biosynthesis of amino acids_Homo sapiens_hsa012300.12648450
125Carbon metabolism_Homo sapiens_hsa012000.12582696
126Drug metabolism - other enzymes_Homo sapiens_hsa009830.12109150
127Pertussis_Homo sapiens_hsa051330.11838346
128mRNA surveillance pathway_Homo sapiens_hsa030150.10779695
129Vitamin digestion and absorption_Homo sapiens_hsa049770.10676200
130Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.10661647
131Histidine metabolism_Homo sapiens_hsa003400.10260014
132NOD-like receptor signaling pathway_Homo sapiens_hsa046210.04981056

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