PDS5B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that interacts with the conserved protein complex termed cohesin. The cohesin complex holds together sister chromatids and facilitates accurate chromosome segregation during mitosis and meiosis. This protein is also a negative regulator of cell proliferation and may be a tumor-suppressor gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)4.48986650
2* mitotic sister chromatid cohesion (GO:0007064)4.09862426
3regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.09283218
4presynaptic membrane organization (GO:0097090)3.96513744
5negative regulation of DNA-dependent DNA replication (GO:2000104)3.83139217
6pre-miRNA processing (GO:0031054)3.82908364
7positive regulation of dendritic spine morphogenesis (GO:0061003)3.64266941
8regulation of short-term neuronal synaptic plasticity (GO:0048172)3.61672927
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.55884832
10replication fork processing (GO:0031297)3.54438807
11pyrimidine nucleobase catabolic process (GO:0006208)3.52857853
12positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.52574954
13protein K6-linked ubiquitination (GO:0085020)3.48610134
14vocalization behavior (GO:0071625)3.46743964
15layer formation in cerebral cortex (GO:0021819)3.46499202
16regulation of DNA endoreduplication (GO:0032875)3.42926851
17locomotory exploration behavior (GO:0035641)3.42482585
18positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.37471348
19regulation of glutamate receptor signaling pathway (GO:1900449)3.34308795
20neuron cell-cell adhesion (GO:0007158)3.25589369
21nuclear pore complex assembly (GO:0051292)3.24092832
22limb bud formation (GO:0060174)3.21759293
23DNA unwinding involved in DNA replication (GO:0006268)3.19209988
24ionotropic glutamate receptor signaling pathway (GO:0035235)3.16016586
25negative regulation of translation, ncRNA-mediated (GO:0040033)3.14668446
26regulation of translation, ncRNA-mediated (GO:0045974)3.14668446
27negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.14668446
28axonal fasciculation (GO:0007413)3.13522977
29sister chromatid segregation (GO:0000819)3.11809410
30synaptic vesicle docking involved in exocytosis (GO:0016081)3.11634453
31inositol phosphate catabolic process (GO:0071545)3.11282148
32histone H2A acetylation (GO:0043968)3.10998961
33synaptic vesicle maturation (GO:0016188)3.10563531
34protein localization to synapse (GO:0035418)3.09450106
35cytoplasmic mRNA processing body assembly (GO:0033962)3.08645733
36nuclear pore organization (GO:0006999)3.06616172
37neural tube formation (GO:0001841)3.05262070
38positive regulation of synapse maturation (GO:0090129)3.04478044
39nucleobase catabolic process (GO:0046113)3.03582713
40gamma-aminobutyric acid transport (GO:0015812)3.00854043
41establishment of nucleus localization (GO:0040023)2.98593909
42glucocorticoid receptor signaling pathway (GO:0042921)2.97658134
43neuron recognition (GO:0008038)2.96250514
44regulation of glucokinase activity (GO:0033131)2.91800133
45regulation of hexokinase activity (GO:1903299)2.91800133
46regulation of protein glycosylation (GO:0060049)2.89877822
47synaptic vesicle exocytosis (GO:0016079)2.89564815
48maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.89057748
49regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.88113598
50proline transport (GO:0015824)2.87945916
51regulation of long-term neuronal synaptic plasticity (GO:0048169)2.87693956
52regulation of dendritic spine morphogenesis (GO:0061001)2.87545390
53exploration behavior (GO:0035640)2.87420373
54mRNA splice site selection (GO:0006376)2.87321127
55negative regulation of DNA recombination (GO:0045910)2.86875860
56resolution of meiotic recombination intermediates (GO:0000712)2.85327337
57respiratory chain complex IV assembly (GO:0008535)2.81071701
58negative regulation of dendrite development (GO:2000171)2.78947749
59regulation of synaptic vesicle exocytosis (GO:2000300)2.78867137
60dendritic spine morphogenesis (GO:0060997)2.78734310
61regulation of telomere maintenance (GO:0032204)2.78642676
62glutamate receptor signaling pathway (GO:0007215)2.78582421
63kidney morphogenesis (GO:0060993)2.76358870
64glycosphingolipid biosynthetic process (GO:0006688)2.76201018
65negative regulation of histone methylation (GO:0031061)2.74961627
66regulation of centriole replication (GO:0046599)2.74523338
67cerebellar Purkinje cell differentiation (GO:0021702)2.73204062
68synapsis (GO:0007129)2.72053353
69mitotic chromosome condensation (GO:0007076)2.69711735
70innervation (GO:0060384)2.69509609
71regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.68765104
72intraciliary transport (GO:0042073)2.68636544
73response to pheromone (GO:0019236)2.65291038
74synaptic vesicle endocytosis (GO:0048488)2.65076631
75detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.63151297
76peptidyl-lysine dimethylation (GO:0018027)2.61959132
77regulation of meiosis I (GO:0060631)2.61851730
78synaptic transmission, glutamatergic (GO:0035249)2.61354284
79atrial cardiac muscle cell action potential (GO:0086014)2.61145614
80protein prenylation (GO:0018342)2.60138878
81prenylation (GO:0097354)2.60138878
82neurotransmitter secretion (GO:0007269)2.59783087
83single strand break repair (GO:0000012)2.59179749
84microtubule anchoring (GO:0034453)2.58703348
85kinetochore organization (GO:0051383)2.58234412
86glutamate secretion (GO:0014047)2.57050352
87recombinational repair (GO:0000725)2.56980638
88double-strand break repair via homologous recombination (GO:0000724)2.56766895
89positive regulation of glycoprotein biosynthetic process (GO:0010560)2.56621674
90histone exchange (GO:0043486)2.56509877
91lactate metabolic process (GO:0006089)2.56352085
92regulation of RNA export from nucleus (GO:0046831)2.55511568
93centriole replication (GO:0007099)2.55274982
94water-soluble vitamin biosynthetic process (GO:0042364)2.55024150
95stress granule assembly (GO:0034063)2.55009650
96positive regulation of dendrite morphogenesis (GO:0050775)2.54472385
97chromatin remodeling at centromere (GO:0031055)2.53354817
98keratinocyte development (GO:0003334)2.53246274
99regulation of neuronal synaptic plasticity (GO:0048168)2.52925586
100central nervous system projection neuron axonogenesis (GO:0021952)2.51843027
101regulation of nuclear cell cycle DNA replication (GO:0033262)2.51728602
102retinal cone cell development (GO:0046549)2.49716316
103cilium morphogenesis (GO:0060271)2.49604183
104dendrite morphogenesis (GO:0048813)2.48374332
105neuronal action potential propagation (GO:0019227)2.47815397
106mitotic sister chromatid segregation (GO:0000070)2.47336807
107negative regulation of cytosolic calcium ion concentration (GO:0051481)2.47166748
108polyol catabolic process (GO:0046174)2.46271452
109behavioral fear response (GO:0001662)2.45801009
110behavioral defense response (GO:0002209)2.45801009
111histone H3-K4 trimethylation (GO:0080182)2.44835087
112neuron-neuron synaptic transmission (GO:0007270)2.44771550
113regulation of sister chromatid cohesion (GO:0007063)2.43304553
114establishment of protein localization to Golgi (GO:0072600)2.43175762
115nucleus localization (GO:0051647)2.43161284
116regulation of excitatory postsynaptic membrane potential (GO:0060079)2.41370400
117cilium organization (GO:0044782)2.41196212
118vesicle transport along microtubule (GO:0047496)2.40501429
119CENP-A containing nucleosome assembly (GO:0034080)2.40253032
120regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.39414790
121retinal ganglion cell axon guidance (GO:0031290)2.39124516
122inositol phosphate dephosphorylation (GO:0046855)2.38904034
123phosphorylated carbohydrate dephosphorylation (GO:0046838)2.38904034
124cilium assembly (GO:0042384)2.38378696
125L-fucose metabolic process (GO:0042354)2.38335514
126L-fucose catabolic process (GO:0042355)2.38335514
127fucose catabolic process (GO:0019317)2.38335514
128cytochrome complex assembly (GO:0017004)2.37948500
129positive regulation of amino acid transport (GO:0051957)2.37272074
130presynaptic membrane assembly (GO:0097105)2.37258441
131DNA topological change (GO:0006265)2.37081824
132regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.37041287
133protein K11-linked deubiquitination (GO:0035871)2.36189914
134Golgi to endosome transport (GO:0006895)2.36153455
135postreplication repair (GO:0006301)2.35877572
136prostate gland growth (GO:0060736)2.35714324
137regulation of mitotic spindle checkpoint (GO:1903504)2.34995177
138regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.34995177
139regulation of synapse structural plasticity (GO:0051823)2.33784756
140kinetochore assembly (GO:0051382)2.33553516
141RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.33449710
142regulation of postsynaptic membrane potential (GO:0060078)2.32381223
143regulation of synapse maturation (GO:0090128)2.32031819
144regulation of synaptic vesicle transport (GO:1902803)2.31851002
145hindbrain development (GO:0030902)2.31674032
146positive regulation of mRNA processing (GO:0050685)2.31215051
147postsynaptic membrane organization (GO:0001941)2.30117253
148regulation of centrosome duplication (GO:0010824)2.30051632
149olfactory bulb development (GO:0021772)2.29631350
150regulation of nucleobase-containing compound transport (GO:0032239)2.28104383
151pancreas development (GO:0031016)2.28061941
152protein polyglutamylation (GO:0018095)2.27780462
153NLS-bearing protein import into nucleus (GO:0006607)2.26543183
154positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.26514228
155protein targeting to Golgi (GO:0000042)2.26046650
156corticosteroid receptor signaling pathway (GO:0031958)2.25887994
157positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.25878445
158positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.25878445
159positive regulation of mitotic sister chromatid separation (GO:1901970)2.25878445
160startle response (GO:0001964)2.25437268
161positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.25002406
162regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.25002406
163signal peptide processing (GO:0006465)2.24637917
164G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.24231252
165negative regulation of DNA repair (GO:0045738)2.23996558
166DNA catabolic process, exonucleolytic (GO:0000738)2.23257563
167peptidyl-cysteine modification (GO:0018198)2.22102674
168vascular smooth muscle contraction (GO:0014829)2.21948245
169regulation of mRNA 3-end processing (GO:0031440)2.21913266
170regulation of histone H3-K9 methylation (GO:0051570)2.21593063
171histone lysine methylation (GO:0034968)2.21058097
172negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.19940885
173neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.19509039
174synapse assembly (GO:0007416)2.19141996
175peptidyl-lysine trimethylation (GO:0018023)2.17880849
176regulation of dendritic spine development (GO:0060998)2.17767807
177positive regulation of dendritic spine development (GO:0060999)2.17727156
178long-term synaptic potentiation (GO:0060291)2.16955900
179G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.16595325
180response to histamine (GO:0034776)2.15968887
181fear response (GO:0042596)2.15839110
182cerebellum development (GO:0021549)2.15324906
183protein localization to kinetochore (GO:0034501)2.15228192
184intraspecies interaction between organisms (GO:0051703)2.15162631
185social behavior (GO:0035176)2.15162631
186peptidyl-threonine phosphorylation (GO:0018107)2.14502033

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.13325531
2EZH2_22144423_ChIP-Seq_EOC_Human4.36075074
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.25805532
4RBPJ_22232070_ChIP-Seq_NCS_Mouse3.04711682
5GBX2_23144817_ChIP-Seq_PC3_Human2.89144856
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.74568445
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.74560487
8ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.70976025
9VDR_22108803_ChIP-Seq_LS180_Human2.55509344
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.40974365
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.25592745
12FUS_26573619_Chip-Seq_HEK293_Human2.23076629
13* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.20459839
14* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.11239411
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.08542500
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.04109265
17JARID2_20064375_ChIP-Seq_MESCs_Mouse2.02381444
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.97116228
19EGR1_19374776_ChIP-ChIP_THP-1_Human1.86117366
20SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.83638498
21RARB_27405468_Chip-Seq_BRAIN_Mouse1.83616253
22HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.81469663
23SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.80085515
24POU3F2_20337985_ChIP-ChIP_501MEL_Human1.79412943
25CTBP2_25329375_ChIP-Seq_LNCAP_Human1.78779557
26TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.78690636
27* EWS_26573619_Chip-Seq_HEK293_Human1.75742560
28TAF15_26573619_Chip-Seq_HEK293_Human1.75582569
29EZH2_27304074_Chip-Seq_ESCs_Mouse1.70281866
30* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.69154211
31* SMAD4_21799915_ChIP-Seq_A2780_Human1.66508993
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.65267948
33IGF1R_20145208_ChIP-Seq_DFB_Human1.64233593
34AR_21572438_ChIP-Seq_LNCaP_Human1.63800998
35PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.63168148
36PCGF2_27294783_Chip-Seq_ESCs_Mouse1.63144166
37TP53_16413492_ChIP-PET_HCT116_Human1.61786729
38RNF2_18974828_ChIP-Seq_MESCs_Mouse1.61634067
39EZH2_18974828_ChIP-Seq_MESCs_Mouse1.61634067
40REST_21632747_ChIP-Seq_MESCs_Mouse1.59028422
41P300_19829295_ChIP-Seq_ESCs_Human1.56462635
42UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.54768096
43SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.54226633
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53825948
45KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.53785863
46TP63_19390658_ChIP-ChIP_HaCaT_Human1.51461211
47RNF2_27304074_Chip-Seq_ESCs_Mouse1.50596266
48SMAD_19615063_ChIP-ChIP_OVARY_Human1.49386389
49NANOG_18555785_Chip-Seq_ESCs_Mouse1.49048635
50BCAT_22108803_ChIP-Seq_LS180_Human1.48878312
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47927140
52E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.46871718
53FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.45783316
54CBP_20019798_ChIP-Seq_JUKART_Human1.45344263
55IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45344263
56ZNF274_21170338_ChIP-Seq_K562_Hela1.44575127
57* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.44572555
58EZH2_27294783_Chip-Seq_NPCs_Mouse1.44495992
59CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.43613948
60SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.43288795
61WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.42277435
62STAT3_23295773_ChIP-Seq_U87_Human1.41968712
63JARID2_20075857_ChIP-Seq_MESCs_Mouse1.41763663
64EED_16625203_ChIP-ChIP_MESCs_Mouse1.40874062
65SUZ12_27294783_Chip-Seq_NPCs_Mouse1.40048717
66OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39862533
67DROSHA_22980978_ChIP-Seq_HELA_Human1.39694883
68ZFP57_27257070_Chip-Seq_ESCs_Mouse1.39353917
69HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.38712310
70SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.38711378
71ELK1_19687146_ChIP-ChIP_HELA_Human1.38271475
72TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.37108261
73RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.35133045
74YAP1_20516196_ChIP-Seq_MESCs_Mouse1.34305414
75BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.33954770
76SMAD3_21741376_ChIP-Seq_EPCs_Human1.33278597
77MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.32431820
78EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.32334951
79PKCTHETA_26484144_Chip-Seq_BREAST_Human1.31325621
80SOX2_21211035_ChIP-Seq_LN229_Gbm1.30259102
81FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.29308186
82NFE2_27457419_Chip-Seq_LIVER_Mouse1.28890576
83NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.28570947
84* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.27913239
85P53_22387025_ChIP-Seq_ESCs_Mouse1.27653311
86* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.26711774
87SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.25922450
88TCF4_23295773_ChIP-Seq_U87_Human1.25588882
89EST1_17652178_ChIP-ChIP_JURKAT_Human1.25247766
90AR_19668381_ChIP-Seq_PC3_Human1.24989582
91PIAS1_25552417_ChIP-Seq_VCAP_Human1.24383448
92SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24347027
93SOX9_26525672_Chip-Seq_HEART_Mouse1.23668600
94RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.23629237
95RNF2_27304074_Chip-Seq_NSC_Mouse1.22885656
96E2F1_18555785_Chip-Seq_ESCs_Mouse1.21554592
97CBX2_27304074_Chip-Seq_ESCs_Mouse1.21229247
98MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.20584049
99TCF4_22108803_ChIP-Seq_LS180_Human1.19547884
100CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.19128761
101WT1_19549856_ChIP-ChIP_CCG9911_Human1.19110632
102EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18637885
103TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18188854
104ARNT_22903824_ChIP-Seq_MCF-7_Human1.17531061
105SUZ12_18555785_Chip-Seq_ESCs_Mouse1.17333319
106CMYC_18555785_Chip-Seq_ESCs_Mouse1.17033635
107PCGF2_27294783_Chip-Seq_NPCs_Mouse1.17029312
108AR_25329375_ChIP-Seq_VCAP_Human1.16809220
109TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16371370
110POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16371370
111* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.14864643
112ESR1_15608294_ChIP-ChIP_MCF-7_Human1.13911671
113FLI1_21867929_ChIP-Seq_TH2_Mouse1.13719145
114NANOG_19829295_ChIP-Seq_ESCs_Human1.12604003
115SOX2_19829295_ChIP-Seq_ESCs_Human1.12604003
116RING1B_27294783_Chip-Seq_NPCs_Mouse1.12339583
117P300_18555785_Chip-Seq_ESCs_Mouse1.12150590
118FOXM1_26456572_ChIP-Seq_MCF-7_Human1.11620811
119REST_18959480_ChIP-ChIP_MESCs_Mouse1.10839069
120E2F1_21310950_ChIP-Seq_MCF-7_Human1.10430838
121TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09637628
122PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09557125
123SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.07789493
124TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07768999
125* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07538123
126TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07503594
127TCF4_18268006_ChIP-ChIP_LS174T_Human1.07465823
128SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07251239
129CRX_20693478_ChIP-Seq_RETINA_Mouse1.07079253
130EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.06868458
131GABP_17652178_ChIP-ChIP_JURKAT_Human1.06423955
132SMAD4_21741376_ChIP-Seq_EPCs_Human1.05975788
133GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05911893
134ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05376619
135STAT3_18555785_Chip-Seq_ESCs_Mouse1.05114037
136ZFP281_27345836_Chip-Seq_ESCs_Mouse1.04956405
137CDX2_19796622_ChIP-Seq_MESCs_Mouse1.04496940
138POU5F1_16153702_ChIP-ChIP_HESCs_Human1.04015902
139NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02780346
140PRDM14_20953172_ChIP-Seq_ESCs_Human1.02534504
141TAL1_26923725_Chip-Seq_HPCs_Mouse1.02070508
142TP53_22573176_ChIP-Seq_HFKS_Human1.01674187
143BMI1_23680149_ChIP-Seq_NPCS_Mouse1.01431244
144ISL1_27105846_Chip-Seq_CPCs_Mouse1.00648647
145* RUNX2_22187159_ChIP-Seq_PCA_Human0.98352781
146EZH2_27294783_Chip-Seq_ESCs_Mouse0.97796413
147PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.97794055
148ER_23166858_ChIP-Seq_MCF-7_Human0.96867519
149NR3C1_23031785_ChIP-Seq_PC12_Mouse0.95874218

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.06298603
2MP0003787_abnormal_imprinting3.19836807
3MP0003880_abnormal_central_pattern3.01551893
4MP0003122_maternal_imprinting3.01238029
5MP0003121_genomic_imprinting3.00670646
6MP0000569_abnormal_digit_pigmentation2.84604892
7MP0003123_paternal_imprinting2.75164779
8MP0003635_abnormal_synaptic_transmissio2.68795620
9MP0002102_abnormal_ear_morphology2.38033323
10MP0002063_abnormal_learning/memory/cond2.26194586
11MP0008877_abnormal_DNA_methylation2.07337274
12MP0001984_abnormal_olfaction2.02664006
13MP0004270_analgesia1.95616519
14MP0009745_abnormal_behavioral_response1.94963555
15MP0008058_abnormal_DNA_repair1.94305513
16MP0002837_dystrophic_cardiac_calcinosis1.84040462
17MP0002572_abnormal_emotion/affect_behav1.77485931
18MP0005551_abnormal_eye_electrophysiolog1.74076938
19MP0005187_abnormal_penis_morphology1.73947012
20MP0005253_abnormal_eye_physiology1.70617215
21MP0002064_seizures1.70103122
22MP0000427_abnormal_hair_cycle1.69437964
23MP0000778_abnormal_nervous_system1.68065070
24MP0003890_abnormal_embryonic-extraembry1.64181335
25MP0003195_calcinosis1.62361146
26MP0001188_hyperpigmentation1.60313566
27MP0009780_abnormal_chondrocyte_physiolo1.60093172
28MP0005174_abnormal_tail_pigmentation1.58272662
29MP0008057_abnormal_DNA_replication1.56295787
30MP0001968_abnormal_touch/_nociception1.54091226
31MP0000631_abnormal_neuroendocrine_gland1.52200243
32MP0002184_abnormal_innervation1.49828940
33MP0010094_abnormal_chromosome_stability1.49111345
34MP0005379_endocrine/exocrine_gland_phen1.45222702
35MP0001486_abnormal_startle_reflex1.45051011
36MP0005423_abnormal_somatic_nervous1.43105700
37MP0009046_muscle_twitch1.39119532
38MP0004811_abnormal_neuron_physiology1.35656998
39MP0002557_abnormal_social/conspecific_i1.33417828
40MP0002163_abnormal_gland_morphology1.32633527
41MP0000647_abnormal_sebaceous_gland1.31815614
42MP0001529_abnormal_vocalization1.31655453
43MP0002938_white_spotting1.29850060
44MP0006292_abnormal_olfactory_placode1.29016471
45MP0002272_abnormal_nervous_system1.28886971
46MP0005367_renal/urinary_system_phenotyp1.28333381
47MP0000516_abnormal_urinary_system1.28333381
48MP0003861_abnormal_nervous_system1.28151524
49MP0005075_abnormal_melanosome_morpholog1.25319270
50MP0001299_abnormal_eye_distance/1.23785708
51MP0004885_abnormal_endolymph1.22404020
52MP0002734_abnormal_mechanical_nocicepti1.22113735
53MP0005646_abnormal_pituitary_gland1.21322148
54MP0002067_abnormal_sensory_capabilities1.21178899
55MP0003385_abnormal_body_wall1.20518196
56MP0002909_abnormal_adrenal_gland1.20410693
57* MP0002751_abnormal_autonomic_nervous1.19355846
58MP0002152_abnormal_brain_morphology1.18954151
59MP0004924_abnormal_behavior1.18783674
60MP0005386_behavior/neurological_phenoty1.18783674
61MP0003111_abnormal_nucleus_morphology1.18625596
62* MP0003935_abnormal_craniofacial_develop1.17972932
63MP0000372_irregular_coat_pigmentation1.15595865
64MP0003937_abnormal_limbs/digits/tail_de1.14612044
65MP0002638_abnormal_pupillary_reflex1.13377687
66MP0003136_yellow_coat_color1.11240446
67MP0000955_abnormal_spinal_cord1.11162952
68MP0005394_taste/olfaction_phenotype1.10092998
69MP0005499_abnormal_olfactory_system1.10092998
70MP0004215_abnormal_myocardial_fiber1.08865044
71MP0002084_abnormal_developmental_patter1.08247258
72MP0002928_abnormal_bile_duct1.06979319
73MP0008569_lethality_at_weaning1.06409268
74MP0001485_abnormal_pinna_reflex1.06122787
75MP0000537_abnormal_urethra_morphology1.05732433
76MP0000534_abnormal_ureter_morphology1.05410352
77MP0002009_preneoplasia1.04893011
78MP0010030_abnormal_orbit_morphology1.04845516
79MP0008995_early_reproductive_senescence1.04817919
80MP0002882_abnormal_neuron_morphology1.02895964
81MP0006276_abnormal_autonomic_nervous1.01505525
82MP0004142_abnormal_muscle_tone1.01305838
83* MP0009703_decreased_birth_body1.00884491
84MP0002095_abnormal_skin_pigmentation1.00264592
85MP0005076_abnormal_cell_differentiation0.99942782
86* MP0003755_abnormal_palate_morphology0.99580939
87MP0000428_abnormal_craniofacial_morphol0.99524490
88MP0003283_abnormal_digestive_organ0.99018090
89MP0003938_abnormal_ear_development0.98700112
90MP0003942_abnormal_urinary_system0.98401617
91MP0003119_abnormal_digestive_system0.97652434
92MP0004233_abnormal_muscle_weight0.97296433
93MP0010307_abnormal_tumor_latency0.96487987
94MP0002234_abnormal_pharynx_morphology0.94430156
95MP0001501_abnormal_sleep_pattern0.94276921
96MP0008789_abnormal_olfactory_epithelium0.93953088
97MP0002735_abnormal_chemical_nociception0.93470819
98MP0004043_abnormal_pH_regulation0.91611180
99MP0002160_abnormal_reproductive_system0.91601915
100MP0002736_abnormal_nociception_after0.91232066
101MP0005220_abnormal_exocrine_pancreas0.90767968
102MP0001440_abnormal_grooming_behavior0.90733831
103MP0010678_abnormal_skin_adnexa0.90220518
104MP0005409_darkened_coat_color0.89706036
105MP0004133_heterotaxia0.88985281
106MP0003786_premature_aging0.88849270
107MP0002085_abnormal_embryonic_tissue0.88569117
108MP0003077_abnormal_cell_cycle0.88305082
109MP0000049_abnormal_middle_ear0.87788365
110* MP0002081_perinatal_lethality0.87459179
111MP0004808_abnormal_hematopoietic_stem0.87122353
112* MP0001929_abnormal_gametogenesis0.86826249
113MP0005248_abnormal_Harderian_gland0.86650346
114MP0006072_abnormal_retinal_apoptosis0.86564612
115MP0002733_abnormal_thermal_nociception0.86378355
116MP0001502_abnormal_circadian_rhythm0.86201288
117MP0005623_abnormal_meninges_morphology0.86170990
118* MP0002116_abnormal_craniofacial_bone0.86009164
119MP0003718_maternal_effect0.85822432
120MP0000383_abnormal_hair_follicle0.85724085
121* MP0004197_abnormal_fetal_growth/weight/0.85602001
122MP0000015_abnormal_ear_pigmentation0.85585446
123MP0009697_abnormal_copulation0.85360505
124MP0005084_abnormal_gallbladder_morpholo0.84529520
125MP0001986_abnormal_taste_sensitivity0.84394082
126* MP0009250_abnormal_appendicular_skeleto0.83884134
127MP0001177_atelectasis0.83733237
128MP0004147_increased_porphyrin_level0.82417428
129MP0005171_absent_coat_pigmentation0.82386954
130MP0005645_abnormal_hypothalamus_physiol0.81573661
131MP0003698_abnormal_male_reproductive0.81376131
132MP0002822_catalepsy0.80434130
133MP0001293_anophthalmia0.80157756
134MP0002066_abnormal_motor_capabilities/c0.80025088
135MP0003567_abnormal_fetal_cardiomyocyte0.79407708
136MP0002752_abnormal_somatic_nervous0.78487259
137MP0001697_abnormal_embryo_size0.78430305
138MP0002210_abnormal_sex_determination0.78069040
139MP0010234_abnormal_vibrissa_follicle0.77665522
140MP0005380_embryogenesis_phenotype0.77554635
141MP0001672_abnormal_embryogenesis/_devel0.77554635
142MP0003115_abnormal_respiratory_system0.77509896
143MP0000653_abnormal_sex_gland0.77031669
144MP0002233_abnormal_nose_morphology0.76894113
145MP0001970_abnormal_pain_threshold0.75609144
146MP0008961_abnormal_basal_metabolism0.75535597
147* MP0002114_abnormal_axial_skeleton0.75294851
148MP0009672_abnormal_birth_weight0.75159301
149MP0000350_abnormal_cell_proliferation0.75078926
150MP0003984_embryonic_growth_retardation0.72108651
151MP0002088_abnormal_embryonic_growth/wei0.71774557

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)4.12651651
2Intestinal atresia (HP:0011100)3.39425972
3Short 4th metacarpal (HP:0010044)3.33605868
4Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.33605868
5Focal motor seizures (HP:0011153)3.18591970
6Pancreatic fibrosis (HP:0100732)3.07103658
7Pancreatic cysts (HP:0001737)3.02411850
8True hermaphroditism (HP:0010459)2.85813797
9Medial flaring of the eyebrow (HP:0010747)2.76467405
10Macroorchidism (HP:0000053)2.74756067
11Hypothermia (HP:0002045)2.68295806
12Nephronophthisis (HP:0000090)2.67556346
13Abnormality of chromosome stability (HP:0003220)2.66438211
14Focal seizures (HP:0007359)2.64754652
15Papilledema (HP:0001085)2.59958316
16Molar tooth sign on MRI (HP:0002419)2.58054757
17Abnormality of midbrain morphology (HP:0002418)2.58054757
18Obsessive-compulsive behavior (HP:0000722)2.57324160
19Increased nuchal translucency (HP:0010880)2.54545562
20Aplasia/Hypoplasia of the uvula (HP:0010293)2.51866394
21Broad-based gait (HP:0002136)2.50050017
22Epileptic encephalopathy (HP:0200134)2.47442896
23Abnormality of the 4th metacarpal (HP:0010012)2.45360120
24Abnormality of the renal cortex (HP:0011035)2.43131680
25Colon cancer (HP:0003003)2.36681630
26Excessive salivation (HP:0003781)2.36403398
27Drooling (HP:0002307)2.36403398
28Febrile seizures (HP:0002373)2.36102785
29Genital tract atresia (HP:0001827)2.35438405
30Abnormality of the renal medulla (HP:0100957)2.34741750
31Protruding tongue (HP:0010808)2.31557618
32Gait imbalance (HP:0002141)2.30382379
33Ankyloglossia (HP:0010296)2.30333032
34Renal duplication (HP:0000075)2.28831031
35Hyperventilation (HP:0002883)2.28571635
36Meckel diverticulum (HP:0002245)2.24617515
37Truncal obesity (HP:0001956)2.24389196
38Renal cortical cysts (HP:0000803)2.24351547
39Hemiparesis (HP:0001269)2.24161926
40Abnormality of the labia minora (HP:0012880)2.24035086
41Abnormality of the ileum (HP:0001549)2.22236995
42Methylmalonic acidemia (HP:0002912)2.21675857
43Tubulointerstitial nephritis (HP:0001970)2.21389001
44Pointed chin (HP:0000307)2.20670388
45Congenital primary aphakia (HP:0007707)2.19965281
46Visual hallucinations (HP:0002367)2.19759172
47Vaginal atresia (HP:0000148)2.19120237
48Aqueductal stenosis (HP:0002410)2.18046190
49Midline defect of the nose (HP:0004122)2.16319465
50Gastrointestinal atresia (HP:0002589)2.15996165
51Astrocytoma (HP:0009592)2.14585595
52Abnormality of the astrocytes (HP:0100707)2.14585595
53Chromsome breakage (HP:0040012)2.14075040
54Abnormal hair whorl (HP:0010721)2.13530905
55Sacral dimple (HP:0000960)2.13277729
56Atonic seizures (HP:0010819)2.12876323
57Chronic hepatic failure (HP:0100626)2.12639169
58Absence seizures (HP:0002121)2.12235022
59Chromosomal breakage induced by crosslinking agents (HP:0003221)2.12036921
60Thyroiditis (HP:0100646)2.08065362
61Progressive cerebellar ataxia (HP:0002073)2.06988167
62Impaired smooth pursuit (HP:0007772)2.06475943
63Neoplasm of the adrenal gland (HP:0100631)2.05825866
64Oligodactyly (hands) (HP:0001180)2.04571461
65Inappropriate behavior (HP:0000719)2.03980744
66Progressive inability to walk (HP:0002505)2.02711853
67Optic nerve hypoplasia (HP:0000609)2.01681181
68Hyperacusis (HP:0010780)2.01442036
69Aplasia/Hypoplasia of the sternum (HP:0006714)2.01060854
70Aplasia/Hypoplasia of the tibia (HP:0005772)1.99941409
71Nephrogenic diabetes insipidus (HP:0009806)1.99641995
72Papillary thyroid carcinoma (HP:0002895)1.98727620
73Poor eye contact (HP:0000817)1.97917838
74Aplasia/Hypoplasia of the tongue (HP:0010295)1.96574343
75Elfin facies (HP:0004428)1.95975866
76Impaired vibration sensation in the lower limbs (HP:0002166)1.95885544
77Progressive macrocephaly (HP:0004481)1.94630432
78Small hand (HP:0200055)1.93539597
79Narrow palate (HP:0000189)1.93405305
80Absent frontal sinuses (HP:0002688)1.92870099
81Hepatoblastoma (HP:0002884)1.91386773
82Abnormality of chromosome segregation (HP:0002916)1.90258865
83Abnormality of ocular smooth pursuit (HP:0000617)1.89943061
84Tented upper lip vermilion (HP:0010804)1.89745626
85Hypoplasia of the maxilla (HP:0000327)1.89447576
86Trigonocephaly (HP:0000243)1.89198511
87Epileptiform EEG discharges (HP:0011182)1.87046015
88Narrow forehead (HP:0000341)1.87022354
89Dialeptic seizures (HP:0011146)1.86821750
90Sloping forehead (HP:0000340)1.86820269
91Impaired social interactions (HP:0000735)1.86605525
92Abnormal social behavior (HP:0012433)1.86605525
93Genetic anticipation (HP:0003743)1.86542658
94Postaxial hand polydactyly (HP:0001162)1.86026858
95Abnormality of the preputium (HP:0100587)1.85534039
96EEG with generalized epileptiform discharges (HP:0011198)1.85422262
97Abnormality of oral frenula (HP:0000190)1.85389272
98Action tremor (HP:0002345)1.85233549
99Hypsarrhythmia (HP:0002521)1.85158682
100Medulloblastoma (HP:0002885)1.84851749
101Cutaneous finger syndactyly (HP:0010554)1.84110574
102Glioma (HP:0009733)1.83192692
103Lissencephaly (HP:0001339)1.82968097
104Thyroid carcinoma (HP:0002890)1.82832351
105Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.82301775
106Truncal ataxia (HP:0002078)1.81826659
107Labial hypoplasia (HP:0000066)1.81609319
108Attention deficit hyperactivity disorder (HP:0007018)1.81469749
109Renovascular hypertension (HP:0100817)1.81141190
110Rhabdomyosarcoma (HP:0002859)1.80800582
111Insomnia (HP:0100785)1.80475024
112Abnormality of the duodenum (HP:0002246)1.80440115
113Long eyelashes (HP:0000527)1.80007679
114Bifid tongue (HP:0010297)1.79294592
115Astigmatism (HP:0000483)1.78766228
116Abnormality of vitamin B metabolism (HP:0004340)1.78705732
117Deep philtrum (HP:0002002)1.78459142
118Cystic liver disease (HP:0006706)1.77825308
119Absent speech (HP:0001344)1.77370011
120Poor coordination (HP:0002370)1.76819572
121Overriding aorta (HP:0002623)1.76676022
122Widely spaced teeth (HP:0000687)1.76486601
123Renal hypoplasia (HP:0000089)1.75413548
124Preaxial hand polydactyly (HP:0001177)1.74762239
125Abnormality of the lower motor neuron (HP:0002366)1.74660446
126Urinary bladder sphincter dysfunction (HP:0002839)1.74058156
127Termporal pattern (HP:0011008)1.73945376
128Insidious onset (HP:0003587)1.73945376
129Autism (HP:0000717)1.73736801
130Abnormality of the fingertips (HP:0001211)1.73143859
131Septo-optic dysplasia (HP:0100842)1.72394670
132Skull defect (HP:0001362)1.72345208
133Myokymia (HP:0002411)1.72231438
134Sclerocornea (HP:0000647)1.72143323
135Short tibia (HP:0005736)1.71900491
136Vertebral arch anomaly (HP:0008438)1.71791217
137Ependymoma (HP:0002888)1.71639789
138Abnormal lung lobation (HP:0002101)1.71493367
139Congenital stationary night blindness (HP:0007642)1.70252402
140Hypoplastic female external genitalia (HP:0012815)1.70211751
141Facial hemangioma (HP:0000329)1.70095154
142Abnormal number of incisors (HP:0011064)1.70063262
143Embryonal renal neoplasm (HP:0011794)1.69046971
144Heterotopia (HP:0002282)1.68690734
145Neoplasm of the adrenal cortex (HP:0100641)1.68494907
146Limb dystonia (HP:0002451)1.68419211
147Hyperthyroidism (HP:0000836)1.66436250
148Gastroesophageal reflux (HP:0002020)1.65571980
149Increased number of teeth (HP:0011069)1.65545820
150Anencephaly (HP:0002323)1.65197237
151Open mouth (HP:0000194)1.64937933
152Broad palm (HP:0001169)1.64605723
153Small intestinal stenosis (HP:0012848)1.64534421
154Duodenal stenosis (HP:0100867)1.64534421
155Thin upper lip vermilion (HP:0000219)1.64487853
156Fair hair (HP:0002286)1.64330048
157Cutaneous syndactyly (HP:0012725)1.64045052
158Thick eyebrow (HP:0000574)1.63941840
159Hypoplastic labia majora (HP:0000059)1.62909581
160Postaxial foot polydactyly (HP:0001830)1.62835794
161Clubbing of toes (HP:0100760)1.62779268
162Inability to walk (HP:0002540)1.62517436
163Neoplasm of the oral cavity (HP:0100649)1.62487350
164Abolished electroretinogram (ERG) (HP:0000550)1.61800225
165Abnormality of the nasal septum (HP:0000419)1.60984109
166Bowel diverticulosis (HP:0005222)1.60822933
167Abnormality of the diencephalon (HP:0010662)1.60625746
168Smooth philtrum (HP:0000319)1.60489374
169Nephroblastoma (Wilms tumor) (HP:0002667)1.60039752
170Amyotrophic lateral sclerosis (HP:0007354)1.59241719
171Shallow orbits (HP:0000586)1.57676455
172Broad thumb (HP:0011304)1.56218927
173Exotropia (HP:0000577)1.55864634
174Gaze-evoked nystagmus (HP:0000640)1.55250474

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.11193180
2NTRK33.99575474
3CDC73.28938754
4MAP3K42.91989324
5EPHA42.91647695
6BMPR1B2.85558476
7MAP4K22.76029169
8TRIM282.66286586
9MARK12.36394287
10CDK122.21760790
11MAP3K92.16354686
12ACVR1B2.14573161
13BRD42.07044870
14MINK12.04116458
15KSR12.01234509
16SIK21.92027266
17PLK21.90687310
18MAP2K71.90550070
19NUAK11.85408027
20NTRK21.73911026
21EIF2AK31.68756833
22PNCK1.64380384
23ZAK1.47556610
24STK38L1.45475499
25WEE11.45189442
26OXSR11.44524435
27STK391.42979587
28PLK41.42526396
29ERBB31.41042697
30PLK31.37699294
31SCYL21.35030928
32MAPK131.33091468
33MST41.30825092
34PAK61.30223077
35CAMK1G1.29563574
36FGFR21.29335178
37MAP2K41.27010143
38CASK1.26945538
39PAK31.24768953
40CSNK1G11.23354351
41MKNK21.19199649
42BRSK21.18750548
43SGK21.16556733
44PRKD31.16433167
45UHMK11.15526087
46DAPK11.14944611
47GRK11.14324052
48CCNB11.11843166
49CAMKK11.10174648
50MKNK11.09677089
51SGK31.04446999
52MAP3K21.03767106
53PINK11.03439413
54NLK1.02880645
55NEK21.02179896
56BUB11.01024103
57ALK1.00565140
58KSR20.97959070
59NEK10.97350088
60FGFR10.97286818
61ADRBK20.96436113
62DAPK20.93752755
63CDK50.93149825
64CHEK10.92487110
65CSNK1G30.91790506
66INSRR0.90731161
67ATR0.89666668
68PRKCE0.88640673
69VRK10.86656286
70DYRK20.85382601
71TYRO30.84844365
72ATM0.84578085
73DMPK0.84143475
74TSSK60.84114266
75DYRK1A0.82774013
76RET0.82679992
77CAMK1D0.81847063
78RIPK40.80651130
79STK30.80111907
80CDK60.79368173
81PRKCG0.78502583
82MELK0.78354554
83TTK0.78075963
84PASK0.77964215
85* CDK10.76693457
86SGK10.76625387
87CHEK20.76404436
88BRSK10.76043359
89TAF10.74366091
90FER0.73415745
91* CDK20.72141289
92LATS10.70969544
93CSNK1G20.66220411
94* MAPK100.66092410
95PDGFRA0.66065438
96WNK10.65450813
97FGFR30.63946265
98* GSK3B0.62616470
99TNIK0.62233402
100CDK180.62233148
101RPS6KB10.61116949
102CDK30.60960174
103AKT30.60850420
104MAPK140.60781433
105PRKDC0.60442551
106CSNK1A1L0.59648037
107PKN20.59610870
108LATS20.59579867
109SGK4940.59571434
110SGK2230.59571434
111WNK30.59036035
112CSNK1E0.58952508
113TGFBR10.58142697
114YES10.57983621
115PTK2B0.56741586
116STK110.56471628
117CDK140.56407246
118CDK150.56116637
119MAP3K120.55982320
120CDK80.55655168
121PRPF4B0.55361330
122EIF2AK10.54540069
123CDK40.54339446
124CDC42BPA0.54145447
125PRKCH0.52793097
126CSNK1D0.52697558
127SIK30.52353151
128SRPK10.52053745
129MAP3K100.51760020
130* RPS6KA30.51448989
131MAPK80.51215739
132PLK10.50189559
133PHKG20.50090155
134PHKG10.50090155
135BCR0.49960038
136CAMK2A0.49452700
137MAP3K70.48995304
138EIF2AK20.48852690
139FES0.47465497
140WNK40.46165589
141IRAK10.44727833
142STK240.44093191
143RPS6KA40.38086775
144CAMK2D0.31810432
145TIE10.30184585
146ADRBK10.29595469
147PRKACB0.29453510
148PRKG10.28769907
149ROCK10.28148360
150CAMKK20.26888344

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.27636413
2Nicotine addiction_Homo sapiens_hsa050332.77182538
3Maturity onset diabetes of the young_Homo sapiens_hsa049502.70620173
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.59359869
5Long-term potentiation_Homo sapiens_hsa047202.46336596
6Butanoate metabolism_Homo sapiens_hsa006502.22634906
7Homologous recombination_Homo sapiens_hsa034402.20244132
8Circadian entrainment_Homo sapiens_hsa047132.08198266
9Amphetamine addiction_Homo sapiens_hsa050312.07167166
10Propanoate metabolism_Homo sapiens_hsa006402.04974470
11Basal transcription factors_Homo sapiens_hsa030221.95960472
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.90786875
13Glutamatergic synapse_Homo sapiens_hsa047241.89556683
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.88541533
15Morphine addiction_Homo sapiens_hsa050321.83674245
16Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.83481569
17Dopaminergic synapse_Homo sapiens_hsa047281.81714673
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.77835997
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.77815742
20Olfactory transduction_Homo sapiens_hsa047401.77472998
21GABAergic synapse_Homo sapiens_hsa047271.75760563
22Long-term depression_Homo sapiens_hsa047301.67011544
23Oocyte meiosis_Homo sapiens_hsa041141.63137010
24GnRH signaling pathway_Homo sapiens_hsa049121.49267397
25Renin secretion_Homo sapiens_hsa049241.47614556
26Oxytocin signaling pathway_Homo sapiens_hsa049211.47427509
27Selenocompound metabolism_Homo sapiens_hsa004501.45644114
28Glioma_Homo sapiens_hsa052141.42013549
29Synaptic vesicle cycle_Homo sapiens_hsa047211.41453394
30Aldosterone synthesis and secretion_Homo sapiens_hsa049251.40855413
31Salivary secretion_Homo sapiens_hsa049701.39995161
32Insulin secretion_Homo sapiens_hsa049111.38374230
33Cholinergic synapse_Homo sapiens_hsa047251.37961888
34Steroid biosynthesis_Homo sapiens_hsa001001.35438021
35Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.34122765
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.33822541
37Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.32861653
38Serotonergic synapse_Homo sapiens_hsa047261.32409363
39Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.30838618
40RNA polymerase_Homo sapiens_hsa030201.29112605
41Taste transduction_Homo sapiens_hsa047421.28788723
42Cell cycle_Homo sapiens_hsa041101.27689800
43Axon guidance_Homo sapiens_hsa043601.27218967
44Cocaine addiction_Homo sapiens_hsa050301.25946558
45Gastric acid secretion_Homo sapiens_hsa049711.25590193
46Gap junction_Homo sapiens_hsa045401.24436190
47Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.23328739
48mRNA surveillance pathway_Homo sapiens_hsa030151.23136803
49Colorectal cancer_Homo sapiens_hsa052101.21992483
50Type II diabetes mellitus_Homo sapiens_hsa049301.21128257
51Wnt signaling pathway_Homo sapiens_hsa043101.17285739
52Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.15449581
53Estrogen signaling pathway_Homo sapiens_hsa049151.14458989
54ErbB signaling pathway_Homo sapiens_hsa040121.13445533
55cGMP-PKG signaling pathway_Homo sapiens_hsa040221.13259039
56Collecting duct acid secretion_Homo sapiens_hsa049661.11001837
57Vitamin B6 metabolism_Homo sapiens_hsa007501.09872148
58Calcium signaling pathway_Homo sapiens_hsa040201.09571672
59cAMP signaling pathway_Homo sapiens_hsa040241.09359303
60Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.09128056
61Melanogenesis_Homo sapiens_hsa049161.09063135
62Dorso-ventral axis formation_Homo sapiens_hsa043201.08011565
63mTOR signaling pathway_Homo sapiens_hsa041501.06898659
64Thyroid hormone signaling pathway_Homo sapiens_hsa049191.05832833
65Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.04775782
66Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.04012187
67Proteasome_Homo sapiens_hsa030501.02903186
68Oxidative phosphorylation_Homo sapiens_hsa001901.02779865
69Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.02774420
70Alcoholism_Homo sapiens_hsa050341.01177546
71Endometrial cancer_Homo sapiens_hsa052131.00315168
72Non-small cell lung cancer_Homo sapiens_hsa052230.99895888
73Phosphatidylinositol signaling system_Homo sapiens_hsa040700.98810013
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.98046473
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.97724415
76Tryptophan metabolism_Homo sapiens_hsa003800.97353186
77Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.97127086
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.95415184
79Nitrogen metabolism_Homo sapiens_hsa009100.93154202
80MicroRNAs in cancer_Homo sapiens_hsa052060.91772344
81MAPK signaling pathway_Homo sapiens_hsa040100.90764658
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.90464286
83Phototransduction_Homo sapiens_hsa047440.88506326
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.88054706
85Fatty acid elongation_Homo sapiens_hsa000620.87997406
86beta-Alanine metabolism_Homo sapiens_hsa004100.87696374
87Choline metabolism in cancer_Homo sapiens_hsa052310.87691516
88Peroxisome_Homo sapiens_hsa041460.85582204
89Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.85112482
90VEGF signaling pathway_Homo sapiens_hsa043700.84157577
91Regulation of autophagy_Homo sapiens_hsa041400.82345399
92One carbon pool by folate_Homo sapiens_hsa006700.80961482
93Hedgehog signaling pathway_Homo sapiens_hsa043400.80011166
94Thyroid hormone synthesis_Homo sapiens_hsa049180.78976498
95Ether lipid metabolism_Homo sapiens_hsa005650.78628552
96Renal cell carcinoma_Homo sapiens_hsa052110.78022157
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76605077
98Rap1 signaling pathway_Homo sapiens_hsa040150.76260257
99Chronic myeloid leukemia_Homo sapiens_hsa052200.76125693
100Basal cell carcinoma_Homo sapiens_hsa052170.75803528
101Glucagon signaling pathway_Homo sapiens_hsa049220.75541340
102Nucleotide excision repair_Homo sapiens_hsa034200.74594449
103Dilated cardiomyopathy_Homo sapiens_hsa054140.73554662
104Adherens junction_Homo sapiens_hsa045200.73390456
105FoxO signaling pathway_Homo sapiens_hsa040680.73210496
106Phospholipase D signaling pathway_Homo sapiens_hsa040720.72880289
107Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72541448
108Circadian rhythm_Homo sapiens_hsa047100.72432044
109Parkinsons disease_Homo sapiens_hsa050120.71875948
110Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.71345978
111RNA transport_Homo sapiens_hsa030130.71229314
112Hippo signaling pathway_Homo sapiens_hsa043900.71172072
113Purine metabolism_Homo sapiens_hsa002300.70875836
114Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.70708654
115Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69284307
116Caffeine metabolism_Homo sapiens_hsa002320.68358995
117Vascular smooth muscle contraction_Homo sapiens_hsa042700.68298329
118Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.67716283
119Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.66758881
120Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.66511424
121Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.65815453
122RNA degradation_Homo sapiens_hsa030180.65760667
123Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.65591152
124Prostate cancer_Homo sapiens_hsa052150.65235299
125Proteoglycans in cancer_Homo sapiens_hsa052050.63975111
126Fanconi anemia pathway_Homo sapiens_hsa034600.63553590
127Melanoma_Homo sapiens_hsa052180.62989817
128Ras signaling pathway_Homo sapiens_hsa040140.62789043
129Lysine degradation_Homo sapiens_hsa003100.62615529
130Non-homologous end-joining_Homo sapiens_hsa034500.62475328
131Pancreatic cancer_Homo sapiens_hsa052120.61634803
132Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.61428586
133Fatty acid metabolism_Homo sapiens_hsa012120.61116843
134Insulin signaling pathway_Homo sapiens_hsa049100.59622805
135Mismatch repair_Homo sapiens_hsa034300.59362619
136Folate biosynthesis_Homo sapiens_hsa007900.58787193
137Linoleic acid metabolism_Homo sapiens_hsa005910.58215200
138Ovarian steroidogenesis_Homo sapiens_hsa049130.57885338
139TGF-beta signaling pathway_Homo sapiens_hsa043500.56432844
140HTLV-I infection_Homo sapiens_hsa051660.56010492
141T cell receptor signaling pathway_Homo sapiens_hsa046600.55397662
142DNA replication_Homo sapiens_hsa030300.55010589
143Spliceosome_Homo sapiens_hsa030400.54414239
144Prolactin signaling pathway_Homo sapiens_hsa049170.54180046
145Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.48890932
146Huntingtons disease_Homo sapiens_hsa050160.48786388
147Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.45826934
148Cysteine and methionine metabolism_Homo sapiens_hsa002700.45069335
149ABC transporters_Homo sapiens_hsa020100.41416001
150Tight junction_Homo sapiens_hsa045300.39038695
151Alzheimers disease_Homo sapiens_hsa050100.38466619
152p53 signaling pathway_Homo sapiens_hsa041150.35576226
153Metabolic pathways_Homo sapiens_hsa011000.34782189

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