PDRG1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.94305127
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.58564832
3viral transcription (GO:0019083)6.51966780
4translational termination (GO:0006415)6.31441332
5ribosomal small subunit biogenesis (GO:0042274)6.03567315
6ATP synthesis coupled proton transport (GO:0015986)5.87511729
7energy coupled proton transport, down electrochemical gradient (GO:0015985)5.87511729
8SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.78736275
9cotranslational protein targeting to membrane (GO:0006613)5.72664476
10translational elongation (GO:0006414)5.71497577
11protein targeting to ER (GO:0045047)5.67542455
12establishment of protein localization to endoplasmic reticulum (GO:0072599)5.46014179
13protein localization to endoplasmic reticulum (GO:0070972)5.45404135
14establishment of protein localization to mitochondrial membrane (GO:0090151)5.40074681
15maturation of SSU-rRNA (GO:0030490)5.09714603
16viral life cycle (GO:0019058)5.03407820
17cellular protein complex disassembly (GO:0043624)4.99855415
18translational initiation (GO:0006413)4.94734183
19DNA deamination (GO:0045006)4.87806248
20mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.75479996
21nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.75396778
22respiratory electron transport chain (GO:0022904)4.68131666
23electron transport chain (GO:0022900)4.58955084
24oxidative phosphorylation (GO:0006119)4.57856919
25chaperone-mediated protein transport (GO:0072321)4.57201394
26proteasome assembly (GO:0043248)4.39903505
27protein complex disassembly (GO:0043241)4.23902262
28rRNA modification (GO:0000154)4.19814299
29negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.19643108
30translation (GO:0006412)4.16139378
31macromolecular complex disassembly (GO:0032984)4.09871049
32protein targeting to membrane (GO:0006612)4.07738063
33L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.01241429
34formation of translation preinitiation complex (GO:0001731)3.98698314
35negative regulation of ligase activity (GO:0051352)3.97970124
36negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.97970124
37ribosomal large subunit biogenesis (GO:0042273)3.95201150
38antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.94912516
39DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.90801456
40mitochondrial respiratory chain complex I assembly (GO:0032981)3.90194906
41NADH dehydrogenase complex assembly (GO:0010257)3.90194906
42mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.90194906
43protein complex biogenesis (GO:0070271)3.87257503
44regulation of cellular amino acid metabolic process (GO:0006521)3.87134815
45signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.81129039
46intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.81129039
47termination of RNA polymerase III transcription (GO:0006386)3.80576051
48transcription elongation from RNA polymerase III promoter (GO:0006385)3.80576051
49positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.79294706
50mitochondrial respiratory chain complex assembly (GO:0033108)3.74734440
51signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.72675521
52signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.72675521
53signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.72675521
54regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.63874368
55metallo-sulfur cluster assembly (GO:0031163)3.62585242
56iron-sulfur cluster assembly (GO:0016226)3.62585242
57signal transduction involved in DNA integrity checkpoint (GO:0072401)3.61894774
58signal transduction involved in DNA damage checkpoint (GO:0072422)3.61894774
59cytochrome complex assembly (GO:0017004)3.61565469
60antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.60779032
61rRNA methylation (GO:0031167)3.60025064
62ribonucleoprotein complex biogenesis (GO:0022613)3.59554193
63signal transduction involved in cell cycle checkpoint (GO:0072395)3.54550838
64protein-cofactor linkage (GO:0018065)3.48286287
65protein targeting to mitochondrion (GO:0006626)3.44978601
66cellular component biogenesis (GO:0044085)3.44339637
67anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.42865758
68tricarboxylic acid cycle (GO:0006099)3.41440525
69tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.36434594
70RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.36434594
71nuclear-transcribed mRNA catabolic process (GO:0000956)3.33698896
72protein deneddylation (GO:0000338)3.32868604
73exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.31571790
74nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.30938402
75pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.30027708
76establishment of protein localization to mitochondrion (GO:0072655)3.26352843
77cullin deneddylation (GO:0010388)3.26292217
78spliceosomal snRNP assembly (GO:0000387)3.25918813
79respiratory chain complex IV assembly (GO:0008535)3.21685647
80regulation of mitochondrial translation (GO:0070129)3.20123790
81positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.19936650
82guanosine-containing compound biosynthetic process (GO:1901070)3.19420659
83NADH metabolic process (GO:0006734)3.19138180
84mRNA catabolic process (GO:0006402)3.15124831
85pseudouridine synthesis (GO:0001522)3.12069985
86positive regulation of ligase activity (GO:0051351)3.11994213
87protein neddylation (GO:0045116)3.11775098
887-methylguanosine mRNA capping (GO:0006370)3.11501863
89regulation of protein heterodimerization activity (GO:0043497)3.10856887
90base-excision repair, AP site formation (GO:0006285)3.10563792
91chromatin remodeling at centromere (GO:0031055)3.07175701
92establishment of protein localization to membrane (GO:0090150)3.07148197
93establishment of integrated proviral latency (GO:0075713)3.05540999
94CENP-A containing nucleosome assembly (GO:0034080)3.04867111
95protein localization to mitochondrion (GO:0070585)3.04103501
96protein targeting (GO:0006605)3.03584058
97deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.02369369
98negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.00162157
99RNA capping (GO:0036260)2.99401788
1007-methylguanosine RNA capping (GO:0009452)2.99401788
101positive regulation of cell cycle arrest (GO:0071158)2.99001984
102water-soluble vitamin biosynthetic process (GO:0042364)2.98477641
103purine-containing compound salvage (GO:0043101)2.96666382
104rRNA processing (GO:0006364)2.94521018
105tRNA processing (GO:0008033)2.92565056
106antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.92062065
107ATP biosynthetic process (GO:0006754)2.91606416
108transcription-coupled nucleotide-excision repair (GO:0006283)2.91508173
109regulation of ubiquitin-protein transferase activity (GO:0051438)2.90593223
110inner mitochondrial membrane organization (GO:0007007)2.90197933
111telomere maintenance via semi-conservative replication (GO:0032201)2.89532547
112L-methionine salvage (GO:0071267)2.89312600
113L-methionine biosynthetic process (GO:0071265)2.89312600
114amino acid salvage (GO:0043102)2.89312600
115purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.88439302
116aerobic respiration (GO:0009060)2.87400945
117positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.86650563
118purine nucleoside triphosphate biosynthetic process (GO:0009145)2.86164121
119mannosylation (GO:0097502)2.85834436
120regulation of ligase activity (GO:0051340)2.85233767
121pyrimidine nucleotide catabolic process (GO:0006244)2.84973344
122DNA replication checkpoint (GO:0000076)2.84871261
123establishment of viral latency (GO:0019043)2.79546025
124intracellular protein transmembrane import (GO:0044743)2.78715994
125rRNA metabolic process (GO:0016072)2.78245245
126ribosome biogenesis (GO:0042254)2.77331953
127intraciliary transport (GO:0042073)2.76889400
128DNA strand elongation involved in DNA replication (GO:0006271)2.75355588
129tRNA metabolic process (GO:0006399)2.74224846
130DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.73319308
131DNA damage response, detection of DNA damage (GO:0042769)2.71821662
132regulation of cellular amine metabolic process (GO:0033238)2.69891153
133GTP biosynthetic process (GO:0006183)2.67919537
134mitotic metaphase plate congression (GO:0007080)2.67547200
135transcription elongation from RNA polymerase II promoter (GO:0006368)2.67088790
136mitochondrial transport (GO:0006839)2.66898072
137DNA strand elongation (GO:0022616)2.66139567
138L-serine metabolic process (GO:0006563)2.61132096
139histone H2A acetylation (GO:0043968)2.60506428
140hydrogen ion transmembrane transport (GO:1902600)2.59845444

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.61953185
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.27656893
3* MYC_18555785_ChIP-Seq_MESCs_Mouse3.88743952
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.84051279
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.74910197
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.71223333
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.66028141
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.60934883
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.59419973
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.41034429
11CREB1_15753290_ChIP-ChIP_HEK293T_Human3.27261928
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.88192175
13* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.74149510
14E2F7_22180533_ChIP-Seq_HELA_Human2.61536240
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.53849262
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.51790537
17SRF_21415370_ChIP-Seq_HL-1_Mouse2.48373131
18VDR_23849224_ChIP-Seq_CD4+_Human2.46880698
19XRN2_22483619_ChIP-Seq_HELA_Human2.44108677
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.39855641
21E2F4_17652178_ChIP-ChIP_JURKAT_Human2.38465190
22CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.30735485
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.28773410
24CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.28479423
25THAP11_20581084_ChIP-Seq_MESCs_Mouse2.26096282
26DCP1A_22483619_ChIP-Seq_HELA_Human2.24974728
27MYC_19030024_ChIP-ChIP_MESCs_Mouse2.22968389
28FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.22967719
29* GABP_19822575_ChIP-Seq_HepG2_Human2.22039626
30* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.18734098
31SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.18719397
32* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.18246988
33FOXP3_21729870_ChIP-Seq_TREG_Human2.15791545
34FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.14269002
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.10732222
36PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.05987300
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.00563070
38PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.96575749
39TTF2_22483619_ChIP-Seq_HELA_Human1.85713755
40CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.85607336
41* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.83268485
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.80434970
43ERG_20887958_ChIP-Seq_HPC-7_Mouse1.75620525
44ELK1_22589737_ChIP-Seq_MCF10A_Human1.75040133
45ELK1_19687146_ChIP-ChIP_HELA_Human1.72048843
46MYC_18940864_ChIP-ChIP_HL60_Human1.69257596
47* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.68937765
48ZNF274_21170338_ChIP-Seq_K562_Hela1.66467049
49YY1_21170310_ChIP-Seq_MESCs_Mouse1.64870671
50SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.63511069
51CIITA_25753668_ChIP-Seq_RAJI_Human1.58961132
52PADI4_21655091_ChIP-ChIP_MCF-7_Human1.54588592
53* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.53170200
54PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50160714
55BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.50135408
56NOTCH1_21737748_ChIP-Seq_TLL_Human1.47082560
57TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41118616
58CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.40636684
59MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.40171957
60CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.38483232
61CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.35382083
62MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.34057793
63ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.32524721
64SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.32458990
65ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.31957427
66RARG_19884340_ChIP-ChIP_MEFs_Mouse1.30487976
67* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.29110653
68ZNF263_19887448_ChIP-Seq_K562_Human1.28238074
69HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.25150066
70E2F1_21310950_ChIP-Seq_MCF-7_Human1.23871466
71POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.23564114
72SPI1_23547873_ChIP-Seq_NB4_Human1.21445470
73VDR_21846776_ChIP-Seq_THP-1_Human1.19376446
74MYC_22102868_ChIP-Seq_BL_Human1.19374629
75E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.18872056
76NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.18062135
77GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.17489885
78MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.17420837
79ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.16859395
80RBPJ_22232070_ChIP-Seq_NCS_Mouse1.16126281
81EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.15664621
82TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.15110492
83NANOG_18555785_ChIP-Seq_MESCs_Mouse1.14463303
84TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12464704
85LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.12318058
86SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.11785958
87YY1_22570637_ChIP-Seq_MALME-3M_Human1.09852739
88POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.08667906
89MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.08209691
90TBX5_21415370_ChIP-Seq_HL-1_Mouse1.08030051
91HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.07889840
92* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07547813
93MYCN_18555785_ChIP-Seq_MESCs_Mouse1.07538784
94IRF1_19129219_ChIP-ChIP_H3396_Human1.05662871
95* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.03629507
96CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.02973653
97* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.00710985
98TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99864697
99TFEB_21752829_ChIP-Seq_HELA_Human0.99825856
100YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.99818349
101SOX2_18555785_ChIP-Seq_MESCs_Mouse0.98680044
102GATA1_22383799_ChIP-Seq_G1ME_Mouse0.97955182
103RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.97346851
104* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.97072373
105ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.96774891
106MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.96362610
107BCL6_27268052_Chip-Seq_Bcells_Human0.95629572
108SOX2_16153702_ChIP-ChIP_HESCs_Human0.94562149
109CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.92604535
110FOXM1_23109430_ChIP-Seq_U2OS_Human0.91814311
111ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.90386728
112SCL_19346495_ChIP-Seq_HPC-7_Human0.89861065
113FOXP1_21924763_ChIP-Seq_HESCs_Human0.89446709
114DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.89325301
115* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.89196027
116GATA4_21415370_ChIP-Seq_HL-1_Mouse0.89047238
117KDM5A_27292631_Chip-Seq_BREAST_Human0.87926124
118CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.87651397
119* CTCF_26484167_Chip-Seq_Bcells_Mouse0.87558466
120NANOG_16153702_ChIP-ChIP_HESCs_Human0.87236535
121TP53_22573176_ChIP-Seq_HFKS_Human0.86953669
122NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.86676497
123IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.86313124
124SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.86111564
125ELK3_25401928_ChIP-Seq_HUVEC_Human0.85963764
126PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.85627017
127ELF1_20517297_ChIP-Seq_JURKAT_Human0.85563742
128SRY_22984422_ChIP-ChIP_TESTIS_Rat0.85125239
129KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.84859149
130* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.84715030
131GATA1_22025678_ChIP-Seq_K562_Human0.84599277
132CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.80288154
133ELF5_23300383_ChIP-Seq_T47D_Human0.79712183
134POU5F1_16153702_ChIP-ChIP_HESCs_Human0.76226811
135AR_21909140_ChIP-Seq_LNCAP_Human0.74344396
136PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.74266654
137SOX17_20123909_ChIP-Seq_XEN_Mouse0.73675401
138VDR_22108803_ChIP-Seq_LS180_Human0.73231582

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000751_myopathy3.81408505
2MP0008058_abnormal_DNA_repair3.45855229
3MP0000749_muscle_degeneration3.38315707
4MP0004084_abnormal_cardiac_muscle3.37744381
5MP0003646_muscle_fatigue3.23291079
6MP0008438_abnormal_cutaneous_collagen3.05152728
7MP0003136_yellow_coat_color2.87560477
8MP0010094_abnormal_chromosome_stability2.81494865
9MP0002837_dystrophic_cardiac_calcinosis2.78190847
10MP0004036_abnormal_muscle_relaxation2.77636245
11MP0006036_abnormal_mitochondrial_physio2.66733825
12MP0008995_early_reproductive_senescence2.54406164
13MP0009379_abnormal_foot_pigmentation2.53093893
14MP0000750_abnormal_muscle_regeneration2.52904075
15MP0000747_muscle_weakness2.50347536
16MP0002396_abnormal_hematopoietic_system2.50077684
17MP0003279_aneurysm2.27157917
18MP0005330_cardiomyopathy2.24707986
19MP0003221_abnormal_cardiomyocyte_apopto2.23499417
20MP0006292_abnormal_olfactory_placode2.22856879
21MP0003111_abnormal_nucleus_morphology2.20841103
22MP0005503_abnormal_tendon_morphology2.12751174
23MP0002653_abnormal_ependyma_morphology2.09039461
24MP0004215_abnormal_myocardial_fiber2.08650134
25MP0002102_abnormal_ear_morphology2.07308943
26MP0006035_abnormal_mitochondrial_morpho2.01845273
27MP0008877_abnormal_DNA_methylation1.95360315
28MP0003718_maternal_effect1.92701696
29MP0004147_increased_porphyrin_level1.92440152
30MP0001986_abnormal_taste_sensitivity1.89723926
31MP0002160_abnormal_reproductive_system1.83835351
32MP0004145_abnormal_muscle_electrophysio1.83455270
33MP0002163_abnormal_gland_morphology1.82705303
34MP0002106_abnormal_muscle_physiology1.80338779
35MP0002938_white_spotting1.80016479
36MP0000013_abnormal_adipose_tissue1.78606279
37MP0008789_abnormal_olfactory_epithelium1.76837670
38MP0009333_abnormal_splenocyte_physiolog1.71547166
39MP0000759_abnormal_skeletal_muscle1.70863269
40MP0003123_paternal_imprinting1.66285760
41MP0006072_abnormal_retinal_apoptosis1.65333679
42MP0003880_abnormal_central_pattern1.64221120
43MP0004087_abnormal_muscle_fiber1.64212974
44MP0005499_abnormal_olfactory_system1.63921415
45MP0005394_taste/olfaction_phenotype1.63921415
46MP0002269_muscular_atrophy1.61313647
47MP0008775_abnormal_heart_ventricle1.60483201
48MP0000343_altered_response_to1.60316362
49MP0005275_abnormal_skin_tensile1.59024694
50MP0002933_joint_inflammation1.55445625
51MP0003763_abnormal_thymus_physiology1.55143046
52MP0005369_muscle_phenotype1.53021398
53MP0000358_abnormal_cell_content/1.51236000
54MP0001984_abnormal_olfaction1.50066854
55MP0002210_abnormal_sex_determination1.48702369
56MP0006054_spinal_hemorrhage1.48607429
57MP0001348_abnormal_lacrimal_gland1.44713578
58MP0005385_cardiovascular_system_phenoty1.41499670
59MP0001544_abnormal_cardiovascular_syste1.41499670
60MP0000465_gastrointestinal_hemorrhage1.39461305
61MP0009046_muscle_twitch1.38572171
62MP0010030_abnormal_orbit_morphology1.38173256
63MP0001542_abnormal_bone_strength1.36882537
64MP0001905_abnormal_dopamine_level1.35045917
65MP0004808_abnormal_hematopoietic_stem1.34933772
66MP0004957_abnormal_blastocyst_morpholog1.33918589
67MP0003121_genomic_imprinting1.33805391
68MP0002972_abnormal_cardiac_muscle1.33738557
69MP0001529_abnormal_vocalization1.33530300
70MP0005620_abnormal_muscle_contractility1.31003407
71MP0003122_maternal_imprinting1.27764687
72MP0001764_abnormal_homeostasis1.27675924
73MP0001929_abnormal_gametogenesis1.27424456
74MP0001968_abnormal_touch/_nociception1.27035130
75MP0003656_abnormal_erythrocyte_physiolo1.26509103
76MP0003806_abnormal_nucleotide_metabolis1.25073651
77MP0001188_hyperpigmentation1.24879065
78MP0004133_heterotaxia1.22335530
79MP0004130_abnormal_muscle_cell1.22271613
80MP0002132_abnormal_respiratory_system1.21214062
81MP0008007_abnormal_cellular_replicative1.20757258
82MP0001145_abnormal_male_reproductive1.20378597
83MP0000653_abnormal_sex_gland1.18528054
84MP0000372_irregular_coat_pigmentation1.18318092
85MP0000631_abnormal_neuroendocrine_gland1.17999252
86MP0001545_abnormal_hematopoietic_system1.17331052
87MP0005397_hematopoietic_system_phenotyp1.17331052
88MP0005389_reproductive_system_phenotype1.15658548
89MP0005379_endocrine/exocrine_gland_phen1.15655355
90MP0002277_abnormal_respiratory_mucosa1.15438990
91MP0000685_abnormal_immune_system1.13066827
92MP0001346_abnormal_lacrimal_gland1.12682519
93MP0005367_renal/urinary_system_phenotyp1.12567005
94MP0000516_abnormal_urinary_system1.12567005
95MP0008875_abnormal_xenobiotic_pharmacok1.12305935
96MP0005645_abnormal_hypothalamus_physiol1.07093698
97MP0004142_abnormal_muscle_tone1.04748487
98MP0003186_abnormal_redox_activity1.04367535
99MP0004134_abnormal_chest_morphology1.04204573
100MP0003137_abnormal_impulse_conducting1.03851620
101MP0001835_abnormal_antigen_presentation1.02244599
102MP0002751_abnormal_autonomic_nervous1.02090967
103MP0004484_altered_response_of1.01741074
104MP0009840_abnormal_foam_cell1.01295431
105MP0009697_abnormal_copulation1.01202128
106MP0005551_abnormal_eye_electrophysiolog0.99881477
107MP0001293_anophthalmia0.99356728
108MP0005410_abnormal_fertilization0.98691801
109MP0001919_abnormal_reproductive_system0.98490774
110MP0001958_emphysema0.96482324
111MP0001853_heart_inflammation0.95570221
112MP0001756_abnormal_urination0.93329773
113MP0003698_abnormal_male_reproductive0.90551373
114MP0008872_abnormal_physiological_respon0.89862145
115MP0002095_abnormal_skin_pigmentation0.89032063
116MP0002398_abnormal_bone_marrow0.88825999
117MP0003786_premature_aging0.88503922
118MP0001119_abnormal_female_reproductive0.87825297
119MP0002090_abnormal_vision0.87567124
120MP0003011_delayed_dark_adaptation0.87475744
121MP0010630_abnormal_cardiac_muscle0.87161850
122MP0003693_abnormal_embryo_hatching0.87009354
123MP0002089_abnormal_postnatal_growth/wei0.86723609
124MP0001324_abnormal_eye_pigmentation0.86616265
125MP0003890_abnormal_embryonic-extraembry0.86581483
126MP0006276_abnormal_autonomic_nervous0.84304976
127MP0002722_abnormal_immune_system0.83675740
128MP0003567_abnormal_fetal_cardiomyocyte0.83068101
129MP0003936_abnormal_reproductive_system0.82881133
130MP0006138_congestive_heart_failure0.82870873
131MP0001697_abnormal_embryo_size0.82829884
132MP0000689_abnormal_spleen_morphology0.81761685
133MP0008260_abnormal_autophagy0.81222586
134MP0002233_abnormal_nose_morphology0.80992406
135MP0005423_abnormal_somatic_nervous0.80785336
136MP0002272_abnormal_nervous_system0.80454700
137MP0003938_abnormal_ear_development0.80026392
138MP0002876_abnormal_thyroid_physiology0.79608672
139MP0003315_abnormal_perineum_morphology0.79323168
140MP0005084_abnormal_gallbladder_morpholo0.78348047
141MP0005220_abnormal_exocrine_pancreas0.77898438
142MP0005253_abnormal_eye_physiology0.77398053
143MP0005023_abnormal_wound_healing0.77178722
144MP0005671_abnormal_response_to0.76130235
145MP0008932_abnormal_embryonic_tissue0.76081963
146MP0000490_abnormal_crypts_of0.75930950
147MP0002429_abnormal_blood_cell0.75475928
148MP0003077_abnormal_cell_cycle0.74665186
149MP0001727_abnormal_embryo_implantation0.74635383
150MP0003724_increased_susceptibility_to0.74156290
151MP0005646_abnormal_pituitary_gland0.73481063
152MP0005464_abnormal_platelet_physiology0.73468140
153MP0009785_altered_susceptibility_to0.73258509
154MP0003942_abnormal_urinary_system0.73078109
155MP0000716_abnormal_immune_system0.72589868
156MP0002928_abnormal_bile_duct0.71358488
157MP0002161_abnormal_fertility/fecundity0.71192464
158MP0005165_increased_susceptibility_to0.71023734
159MP0002638_abnormal_pupillary_reflex0.70464706
160MP0002420_abnormal_adaptive_immunity0.68130892
161MP0004233_abnormal_muscle_weight0.67085339
162MP0000858_altered_metastatic_potential0.66715503
163MP0004085_abnormal_heartbeat0.66166783
164MP0001944_abnormal_pancreas_morphology0.66149187
165MP0001243_abnormal_dermal_layer0.66134390
166MP0000049_abnormal_middle_ear0.66035493
167MP0001881_abnormal_mammary_gland0.65931807
168MP0002736_abnormal_nociception_after0.65018117
169MP0001819_abnormal_immune_cell0.64727753
170MP0005075_abnormal_melanosome_morpholog0.64335667
171MP0000703_abnormal_thymus_morphology0.64040912
172MP0002166_altered_tumor_susceptibility0.63880170
173MP0001299_abnormal_eye_distance/0.62413255
174MP0005508_abnormal_skeleton_morphology0.61989499
175MP0002108_abnormal_muscle_morphology0.61211276

Predicted human phenotypes

RankGene SetZ-score
1Hepatocellular necrosis (HP:0001404)5.03223945
2Acute necrotizing encephalopathy (HP:0006965)5.00459555
3Abnormal mitochondria in muscle tissue (HP:0008316)4.89349714
4Mitochondrial inheritance (HP:0001427)4.72136292
5Abnormality of cells of the erythroid lineage (HP:0012130)4.71394350
6Hepatic necrosis (HP:0002605)4.62409226
7Abnormal number of erythroid precursors (HP:0012131)4.43308707
8Increased CSF lactate (HP:0002490)4.26053575
9Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.22683837
10Decreased activity of mitochondrial respiratory chain (HP:0008972)4.22683837
11Progressive macrocephaly (HP:0004481)4.10588257
12Acute encephalopathy (HP:0006846)3.91127602
13Increased intramyocellular lipid droplets (HP:0012240)3.59053768
14Abnormality of glycolysis (HP:0004366)3.52582763
15Increased serum pyruvate (HP:0003542)3.52582763
16Increased muscle lipid content (HP:0009058)3.43170647
17Protrusio acetabuli (HP:0003179)3.37940300
18Increased hepatocellular lipid droplets (HP:0006565)3.22141332
19Exercise intolerance (HP:0003546)3.20600027
20Lactic acidosis (HP:0003128)3.12096357
21Lipid accumulation in hepatocytes (HP:0006561)3.10350806
22Increased serum lactate (HP:0002151)3.08226226
23Chromosomal breakage induced by crosslinking agents (HP:0003221)3.00700181
24Reticulocytopenia (HP:0001896)2.99767155
25Respiratory failure (HP:0002878)2.99253890
26Muscle fiber splitting (HP:0003555)2.97276150
27Abnormality of midbrain morphology (HP:0002418)2.92559602
28Molar tooth sign on MRI (HP:0002419)2.92559602
29Myotonia (HP:0002486)2.87735639
30Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.85030027
31Aplastic anemia (HP:0001915)2.84867151
32Chromsome breakage (HP:0040012)2.78672262
33Palpitations (HP:0001962)2.78147453
34Multiple enchondromatosis (HP:0005701)2.69928506
35Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.64656725
36Vertebral compression fractures (HP:0002953)2.63610123
37Beaking of vertebral bodies (HP:0004568)2.62046782
38Conjunctival hamartoma (HP:0100780)2.61982498
39Meckel diverticulum (HP:0002245)2.61628255
40Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.60595406
41Type I transferrin isoform profile (HP:0003642)2.60021131
42Abnormality of alanine metabolism (HP:0010916)2.58683490
43Hyperalaninemia (HP:0003348)2.58683490
44Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.58683490
45Thrombocytosis (HP:0001894)2.58201050
46Aplasia/Hypoplasia of the uvula (HP:0010293)2.58031328
47Muscle fiber inclusion bodies (HP:0100299)2.56263550
48Pancreatic cysts (HP:0001737)2.55228570
49Premature rupture of membranes (HP:0001788)2.55041074
50Pallor (HP:0000980)2.54366479
51Nemaline bodies (HP:0003798)2.52744380
52Macrocytic anemia (HP:0001972)2.52624948
53Aplasia/Hypoplasia of the sacrum (HP:0008517)2.51893782
54Neuroendocrine neoplasm (HP:0100634)2.51535021
55Abnormality of the ileum (HP:0001549)2.48273337
56Pancreatic fibrosis (HP:0100732)2.47558119
57Exertional dyspnea (HP:0002875)2.45394707
58Exercise-induced myalgia (HP:0003738)2.45207963
59Cerebral edema (HP:0002181)2.44863702
60Respiratory difficulties (HP:0002880)2.42048503
61True hermaphroditism (HP:0010459)2.41492839
62Abnormality of renal resorption (HP:0011038)2.41220356
63Abnormality of the labia minora (HP:0012880)2.40127348
643-Methylglutaconic aciduria (HP:0003535)2.36727238
65Hyperglycinemia (HP:0002154)2.36513892
66Absent thumb (HP:0009777)2.36255801
67Rhabdomyolysis (HP:0003201)2.31555554
68Nephronophthisis (HP:0000090)2.30241673
69Severe visual impairment (HP:0001141)2.29710876
70Elevated erythrocyte sedimentation rate (HP:0003565)2.29347044
71Abnormality of the preputium (HP:0100587)2.28716846
72Irregular epiphyses (HP:0010582)2.28444164
73Muscle fiber atrophy (HP:0100295)2.27385933
74Distal arthrogryposis (HP:0005684)2.27035943
75Cerebral hypomyelination (HP:0006808)2.26727845
76Type 2 muscle fiber atrophy (HP:0003554)2.25576977
77Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.24220259
78Abnormal protein N-linked glycosylation (HP:0012347)2.24220259
79Abnormal protein glycosylation (HP:0012346)2.24220259
80Abnormal glycosylation (HP:0012345)2.24220259
81Deformed tarsal bones (HP:0008119)2.23825843
82Calcaneovalgus deformity (HP:0001848)2.23752366
83Renal Fanconi syndrome (HP:0001994)2.23119373
84Muscle hypertrophy of the lower extremities (HP:0008968)2.22954917
85Ventricular tachycardia (HP:0004756)2.22462062
86Neoplasm of the adrenal gland (HP:0100631)2.22177336
87CNS demyelination (HP:0007305)2.21895045
88Myoglobinuria (HP:0002913)2.21347476
89Abnormality of urine glucose concentration (HP:0011016)2.19181696
90Glycosuria (HP:0003076)2.19181696
91Calf muscle hypertrophy (HP:0008981)2.18987482
92Medial flaring of the eyebrow (HP:0010747)2.18187399
93Areflexia of lower limbs (HP:0002522)2.16604199
94Duplicated collecting system (HP:0000081)2.16479231
95Emotional lability (HP:0000712)2.15404158
96Pheochromocytoma (HP:0002666)2.15310838
97Horseshoe kidney (HP:0000085)2.14176892
98Ulnar deviation of the wrist (HP:0003049)2.13987323
99Lipoatrophy (HP:0100578)2.11979236
100Sclerocornea (HP:0000647)2.11517285
101Difficulty climbing stairs (HP:0003551)2.11380073
102Type 1 muscle fiber predominance (HP:0003803)2.08981486
103EMG: myopathic abnormalities (HP:0003458)2.07166410
104Abnormality of the renal collecting system (HP:0004742)2.06743791
105Exercise-induced muscle cramps (HP:0003710)2.06249044
106Optic disc pallor (HP:0000543)2.04797545
107Degeneration of anterior horn cells (HP:0002398)2.04705070
108Abnormality of the anterior horn cell (HP:0006802)2.04705070
109Ragged-red muscle fibers (HP:0003200)2.03940444
110Muscle stiffness (HP:0003552)2.03340639
111Limb-girdle muscle atrophy (HP:0003797)2.02653700
112Methylmalonic aciduria (HP:0012120)2.02395506
113Reduced antithrombin III activity (HP:0001976)2.01662949
114Pancytopenia (HP:0001876)2.01204177
115Congenital primary aphakia (HP:0007707)2.01085186
116Gait imbalance (HP:0002141)1.98383069
117Abnormality of chromosome stability (HP:0003220)1.95369795
118Neck muscle weakness (HP:0000467)1.95202482
119Progressive muscle weakness (HP:0003323)1.94155177
120Methylmalonic acidemia (HP:0002912)1.93343798
121Increased variability in muscle fiber diameter (HP:0003557)1.93007228
122Increased connective tissue (HP:0009025)1.92480592
123Lethargy (HP:0001254)1.92251693
124Rimmed vacuoles (HP:0003805)1.91165521
125Nephrogenic diabetes insipidus (HP:0009806)1.88439043
126Abnormal rod and cone electroretinograms (HP:0008323)1.87815131
127Abnormality of skeletal muscle fiber size (HP:0012084)1.87769532
128IgM deficiency (HP:0002850)1.86831575
129Leukodystrophy (HP:0002415)1.86772926
130Abnormality of methionine metabolism (HP:0010901)1.86120051
131Abnormal biliary tract physiology (HP:0012439)1.85989333
132Bile duct proliferation (HP:0001408)1.85989333
133Clubbing of toes (HP:0100760)1.84377701
134Myopathic facies (HP:0002058)1.83985935
135CNS hypomyelination (HP:0003429)1.83631541
136Abnormality of DNA repair (HP:0003254)1.83140592
137Abnormality of the calf musculature (HP:0001430)1.82515878
138Hyperphosphaturia (HP:0003109)1.82043816
139Reduced subcutaneous adipose tissue (HP:0003758)1.80039432
140Oral leukoplakia (HP:0002745)1.80034112
141Generalized aminoaciduria (HP:0002909)1.79909775
142Supraventricular tachycardia (HP:0004755)1.79100755
143Abnormality of the renal medulla (HP:0100957)1.78557971
144Sudden death (HP:0001699)1.78120635
145Aplasia/hypoplasia of the uterus (HP:0008684)1.77794165
146Esophageal neoplasm (HP:0100751)1.77603960
147Neoplasm of head and neck (HP:0012288)1.77603960
148Biconcave vertebral bodies (HP:0004586)1.76668100
149Supraventricular arrhythmia (HP:0005115)1.76174945
150Cervical subluxation (HP:0003308)1.76054404
151X-linked dominant inheritance (HP:0001423)1.75033140
152Hyporeflexia of lower limbs (HP:0002600)1.74841136
153Abnormality of lateral ventricle (HP:0030047)1.74717706
154Abnormality of the vocal cords (HP:0008777)1.72425378
155Aganglionic megacolon (HP:0002251)1.70700012
156Microretrognathia (HP:0000308)1.67614038
157Oculomotor apraxia (HP:0000657)1.66966409
158Hypoplasia of the capital femoral epiphysis (HP:0003090)1.64986442
159Poor suck (HP:0002033)1.64289646
160Hypoplasia of the pons (HP:0012110)1.64105098
161Preaxial hand polydactyly (HP:0001177)1.63317246
162Male pseudohermaphroditism (HP:0000037)1.61847383

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.58353756
2VRK24.29430707
3PIM23.79169797
4STK163.38677092
5MYLK2.76640905
6LIMK12.65595327
7TRIM282.64045707
8MAPKAPK32.55272348
9BUB12.47991803
10PBK2.26893327
11TTN2.23408002
12CDC72.16523513
13NUAK12.15431063
14WNK32.14889526
15CDK192.05613955
16PHKG22.03670044
17PHKG12.03670044
18TESK22.01934918
19LRRK21.90463797
20NME11.85869138
21TRIB31.85671449
22MUSK1.80561769
23MAP3K121.79477726
24ILK1.78404597
25MAP3K31.77489421
26TAOK31.74956879
27MAP2K31.70039317
28PLK31.69367730
29EIF2AK11.67375634
30EEF2K1.64574714
31KDR1.55464014
32DYRK21.51880984
33MAP4K11.51776108
34ZAK1.49329874
35MAP4K21.48765515
36BCKDK1.43148455
37CASK1.42117746
38PDK31.42053642
39PDK41.42053642
40BMPR1B1.41283686
41TESK11.41215197
42TGFBR11.34832688
43PLK11.34719256
44TTK1.34660172
45PKN21.33772830
46ZAP701.32771074
47ARAF1.31675213
48RPS6KB21.30907713
49BCR1.29092379
50DYRK31.27272640
51WEE11.26752786
52GRK11.26599714
53KIT1.22999157
54MAPKAPK51.21246087
55VRK11.16103670
56FLT31.15338695
57BRSK11.14382496
58CAMKK21.11116040
59OBSCN1.10956198
60SIK31.08947699
61EIF2AK31.08732600
62TNIK1.08415773
63BLK1.08064561
64EPHB11.06692641
65TLK11.06651737
66PIK3CG1.06058722
67DAPK31.00434877
68TEC0.98393070
69PLK40.97867345
70MAP2K70.95204760
71MAP3K110.94864920
72STK240.92971713
73SCYL20.90357015
74CCNB10.89511605
75CDK80.87955440
76CHEK20.86375544
77TSSK60.85410270
78CSNK1G20.83826964
79PDK20.83562038
80ATR0.83297658
81SRPK10.81692833
82TAF10.80990750
83PNCK0.78149297
84MKNK20.77040010
85CSNK1G30.76793241
86MAPK130.75243909
87SYK0.75151431
88TAOK10.75086299
89BTK0.74781410
90TRPM70.73651659
91EIF2AK20.73091508
92AURKB0.72843651
93PIK3CA0.71550691
94ADRBK20.71097246
95CSNK2A10.69414549
96DAPK10.69144396
97CSNK1A1L0.67642584
98MAP2K60.66894822
99TBK10.66768460
100FRK0.66330247
101PLK20.61912773
102BRSK20.60274116
103ERN10.59615062
104ACVR1B0.59187753
105PRKCG0.59002930
106EPHA20.58282446
107EPHB20.57450722
108MAPK40.57394421
109AURKA0.56348536
110RPS6KA40.56043742
111ATM0.55098589
112MAPK120.53867568
113CDK90.53451728
114PAK30.51455806
115PAK10.50427485
116CDK70.50212972
117EPHA30.49944470
118AKT20.49841938
119LMTK20.48982649
120CSNK1G10.48832165
121PAK40.48738707
122MKNK10.48697656
123STK38L0.47747367
124OXSR10.47744408
125CSF1R0.47130527
126CHEK10.47061844
127STK390.46828635
128DDR20.46461535
129CSNK1A10.46404428
130PAK20.46336095
131IRAK30.46075789
132MAP3K40.44896957
133NEK10.43990913
134CSNK1E0.43259535
135ERBB30.42907907
136PRKCE0.42328957
137TXK0.41586156
138STK40.41132920
139ABL20.39417502
140LATS20.38581893
141RPS6KA50.38229495
142CDK140.35966389
143PRKG20.35085781
144MAPKAPK20.34435210
145NLK0.34237162
146CSNK2A20.34085944
147TGFBR20.33856029
148MST40.33651456
149TAOK20.33354192
150MAP3K50.32658827
151MINK10.32558786
152PRKCI0.32474300
153BRAF0.32080113
154ROCK10.30171319
155PRKD10.29344253
156TIE10.27742343

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.53817240
2Proteasome_Homo sapiens_hsa030504.83624335
3Oxidative phosphorylation_Homo sapiens_hsa001904.18386215
4Parkinsons disease_Homo sapiens_hsa050124.10742907
5RNA polymerase_Homo sapiens_hsa030203.32978064
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.28995431
7Huntingtons disease_Homo sapiens_hsa050162.71814216
8Alzheimers disease_Homo sapiens_hsa050102.71004120
9Protein export_Homo sapiens_hsa030602.70188778
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.45360509
11DNA replication_Homo sapiens_hsa030302.16809901
12Pyrimidine metabolism_Homo sapiens_hsa002402.08167870
13Cardiac muscle contraction_Homo sapiens_hsa042602.05668880
14Fanconi anemia pathway_Homo sapiens_hsa034601.85962075
15Butanoate metabolism_Homo sapiens_hsa006501.81856751
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.77589314
17Steroid biosynthesis_Homo sapiens_hsa001001.66244205
18Spliceosome_Homo sapiens_hsa030401.65284183
19Nucleotide excision repair_Homo sapiens_hsa034201.57952363
20Mismatch repair_Homo sapiens_hsa034301.51261579
21One carbon pool by folate_Homo sapiens_hsa006701.50622971
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.49190384
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.44324866
24Base excision repair_Homo sapiens_hsa034101.40074699
25Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.35893509
26SNARE interactions in vesicular transport_Homo sapiens_hsa041301.33726751
27Fatty acid elongation_Homo sapiens_hsa000621.29375031
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.29296028
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.28748352
30Purine metabolism_Homo sapiens_hsa002301.27427247
31Selenocompound metabolism_Homo sapiens_hsa004501.25500297
32RNA transport_Homo sapiens_hsa030131.23713488
33Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.10627273
34Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.10303335
35Carbon metabolism_Homo sapiens_hsa012001.06845330
36Homologous recombination_Homo sapiens_hsa034401.03126099
37Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.02217513
38Basal transcription factors_Homo sapiens_hsa030220.99587168
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.99270761
40N-Glycan biosynthesis_Homo sapiens_hsa005100.96274225
41Pentose phosphate pathway_Homo sapiens_hsa000300.92575815
42Epstein-Barr virus infection_Homo sapiens_hsa051690.92533925
43Sulfur relay system_Homo sapiens_hsa041220.92272415
44Sulfur metabolism_Homo sapiens_hsa009200.91271662
45p53 signaling pathway_Homo sapiens_hsa041150.90833488
46Primary immunodeficiency_Homo sapiens_hsa053400.89433994
47Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.87422868
48Pyruvate metabolism_Homo sapiens_hsa006200.86295961
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.77441919
50RNA degradation_Homo sapiens_hsa030180.76742418
51Peroxisome_Homo sapiens_hsa041460.76245041
52Folate biosynthesis_Homo sapiens_hsa007900.74340079
53Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.74273985
54Propanoate metabolism_Homo sapiens_hsa006400.72975023
55Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.71911449
56Regulation of autophagy_Homo sapiens_hsa041400.71588532
57Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.70472394
58mRNA surveillance pathway_Homo sapiens_hsa030150.69372894
59Shigellosis_Homo sapiens_hsa051310.66955848
60Dilated cardiomyopathy_Homo sapiens_hsa054140.66848172
61Viral myocarditis_Homo sapiens_hsa054160.65580899
62Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.64881873
63Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.64574228
64Cell cycle_Homo sapiens_hsa041100.62721965
65Glutathione metabolism_Homo sapiens_hsa004800.61245469
66Vibrio cholerae infection_Homo sapiens_hsa051100.59394822
67Metabolic pathways_Homo sapiens_hsa011000.58915600
68Biosynthesis of amino acids_Homo sapiens_hsa012300.57264639
69Phagosome_Homo sapiens_hsa041450.56766808
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.56069685
71Tryptophan metabolism_Homo sapiens_hsa003800.52549233
72Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48536779
73Oocyte meiosis_Homo sapiens_hsa041140.47779138
74Non-homologous end-joining_Homo sapiens_hsa034500.46343715
75Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.45161556
76beta-Alanine metabolism_Homo sapiens_hsa004100.44066261
77Antigen processing and presentation_Homo sapiens_hsa046120.43888882
78Cysteine and methionine metabolism_Homo sapiens_hsa002700.40789097
79Primary bile acid biosynthesis_Homo sapiens_hsa001200.39281489
80ECM-receptor interaction_Homo sapiens_hsa045120.38067132
81Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37680773
82Hematopoietic cell lineage_Homo sapiens_hsa046400.35448098
83Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.35136097
84Other glycan degradation_Homo sapiens_hsa005110.33586741
85Legionellosis_Homo sapiens_hsa051340.33556539
86Phototransduction_Homo sapiens_hsa047440.33321025
87Maturity onset diabetes of the young_Homo sapiens_hsa049500.32955341
88Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.32884662
89Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.32871158
90Galactose metabolism_Homo sapiens_hsa000520.32677643
91Vitamin B6 metabolism_Homo sapiens_hsa007500.32006149
92HIF-1 signaling pathway_Homo sapiens_hsa040660.31205673
93Cyanoamino acid metabolism_Homo sapiens_hsa004600.30602729
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.30177781
95Drug metabolism - other enzymes_Homo sapiens_hsa009830.30061242
96Platelet activation_Homo sapiens_hsa046110.29757225
97Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.28646653
98Fatty acid metabolism_Homo sapiens_hsa012120.28351499
99Chemical carcinogenesis_Homo sapiens_hsa052040.26999744
100Fructose and mannose metabolism_Homo sapiens_hsa000510.26748017
101Nitrogen metabolism_Homo sapiens_hsa009100.25231237
102PI3K-Akt signaling pathway_Homo sapiens_hsa041510.24350527
103Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.23689406
104Viral carcinogenesis_Homo sapiens_hsa052030.22478928
105Arginine and proline metabolism_Homo sapiens_hsa003300.22365227
106Arachidonic acid metabolism_Homo sapiens_hsa005900.22280317
107Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.21727396
108Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.21691464
109Synaptic vesicle cycle_Homo sapiens_hsa047210.21339593
110Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.21077131
111Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.21035283
112Thyroid cancer_Homo sapiens_hsa052160.20558346
113Fatty acid degradation_Homo sapiens_hsa000710.19038432
114Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.18803918
115Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.18562672
116Apoptosis_Homo sapiens_hsa042100.18101398
117Malaria_Homo sapiens_hsa051440.17043565
118Collecting duct acid secretion_Homo sapiens_hsa049660.17033154
119Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.16363570
120Bladder cancer_Homo sapiens_hsa052190.15537209
121Basal cell carcinoma_Homo sapiens_hsa052170.15203495
122Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.14852758
123Steroid hormone biosynthesis_Homo sapiens_hsa001400.14546164
124Lysosome_Homo sapiens_hsa041420.14007372
125Focal adhesion_Homo sapiens_hsa045100.12919021
126Measles_Homo sapiens_hsa051620.12368171
127Salmonella infection_Homo sapiens_hsa051320.12031662
128Rheumatoid arthritis_Homo sapiens_hsa053230.11794151
129Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.11024445
130Tyrosine metabolism_Homo sapiens_hsa003500.10677146
131Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.10491660
132Sphingolipid metabolism_Homo sapiens_hsa006000.10252529
133Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.08208211

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