PDP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a mitochondrial protein that functions as a phosphatase and is involved in the enzymatic resetting of the pyruvate dehydrogenase complex. Alternative splicing results in multiple transcript variants encoding the same protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1purine nucleobase biosynthetic process (GO:0009113)5.21557589
2behavioral response to nicotine (GO:0035095)5.17562734
3proteasome assembly (GO:0043248)4.93686541
4nucleobase biosynthetic process (GO:0046112)4.73667417
5DNA deamination (GO:0045006)4.71985247
6response to pheromone (GO:0019236)4.64073188
7termination of RNA polymerase III transcription (GO:0006386)4.29326108
8transcription elongation from RNA polymerase III promoter (GO:0006385)4.29326108
9rRNA modification (GO:0000154)4.05734228
10glycine metabolic process (GO:0006544)4.02768662
11regulation of gene silencing by RNA (GO:0060966)4.00173282
12regulation of posttranscriptional gene silencing (GO:0060147)4.00173282
13regulation of gene silencing by miRNA (GO:0060964)4.00173282
14serine family amino acid catabolic process (GO:0009071)3.91737495
15ribosome biogenesis (GO:0042254)3.82898932
16ribosome assembly (GO:0042255)3.77061563
17pantothenate metabolic process (GO:0015939)3.76153491
18mitotic metaphase plate congression (GO:0007080)3.73435667
19cellular ketone body metabolic process (GO:0046950)3.72871728
20GMP metabolic process (GO:0046037)3.70675231
21daunorubicin metabolic process (GO:0044597)3.70343668
22polyketide metabolic process (GO:0030638)3.70343668
23doxorubicin metabolic process (GO:0044598)3.70343668
24regulation of hippo signaling (GO:0035330)3.69226716
25negative regulation of translation, ncRNA-mediated (GO:0040033)3.63761913
26regulation of translation, ncRNA-mediated (GO:0045974)3.63761913
27negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.63761913
28folic acid metabolic process (GO:0046655)3.56662456
29telomere maintenance via semi-conservative replication (GO:0032201)3.51359455
30indolalkylamine metabolic process (GO:0006586)3.39739933
31ketone body metabolic process (GO:1902224)3.37312230
32DNA replication checkpoint (GO:0000076)3.36193424
33rRNA methylation (GO:0031167)3.36004343
34kynurenine metabolic process (GO:0070189)3.35238444
35N-acetylneuraminate metabolic process (GO:0006054)3.35184475
36S-adenosylmethionine metabolic process (GO:0046500)3.32421647
37L-fucose metabolic process (GO:0042354)3.31401883
38L-fucose catabolic process (GO:0042355)3.31401883
39fucose catabolic process (GO:0019317)3.31401883
40ribonucleoprotein complex biogenesis (GO:0022613)3.29754965
41L-methionine salvage (GO:0071267)3.29253458
42L-methionine biosynthetic process (GO:0071265)3.29253458
43amino acid salvage (GO:0043102)3.29253458
44transcription from RNA polymerase I promoter (GO:0006360)3.28635464
45serine family amino acid biosynthetic process (GO:0009070)3.25604393
46regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.22497034
47telomere maintenance via recombination (GO:0000722)3.21807914
48DNA strand elongation involved in DNA replication (GO:0006271)3.21678653
49transcription elongation from RNA polymerase I promoter (GO:0006362)3.20887785
50reflex (GO:0060004)3.20631304
51termination of RNA polymerase I transcription (GO:0006363)3.20611829
52maturation of 5.8S rRNA (GO:0000460)3.15892515
53ribosomal large subunit biogenesis (GO:0042273)3.14850020
54detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.13526860
557-methylguanosine mRNA capping (GO:0006370)3.12963258
56epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.11473255
57serine family amino acid metabolic process (GO:0009069)3.11061008
58DNA strand elongation (GO:0022616)3.09911950
597-methylguanosine RNA capping (GO:0009452)3.09513493
60RNA capping (GO:0036260)3.09513493
61regulation of double-strand break repair via homologous recombination (GO:0010569)3.09325358
62DNA-dependent DNA replication (GO:0006261)3.08682607
63detection of light stimulus involved in visual perception (GO:0050908)3.01552871
64detection of light stimulus involved in sensory perception (GO:0050962)3.01552871
65pseudouridine synthesis (GO:0001522)3.01380246
66G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.01326260
67tRNA methylation (GO:0030488)2.99016701
68water-soluble vitamin biosynthetic process (GO:0042364)2.98856613
69maturation of SSU-rRNA (GO:0030490)2.96450952
70transcription initiation from RNA polymerase I promoter (GO:0006361)2.96428736
71rRNA processing (GO:0006364)2.94469686
72DNA replication initiation (GO:0006270)2.94079578
73CENP-A containing nucleosome assembly (GO:0034080)2.92711955
74vitamin transmembrane transport (GO:0035461)2.92397964
75ribosomal small subunit assembly (GO:0000028)2.90481573
76indole-containing compound catabolic process (GO:0042436)2.90079409
77indolalkylamine catabolic process (GO:0046218)2.90079409
78tryptophan catabolic process (GO:0006569)2.90079409
79metaphase plate congression (GO:0051310)2.87912531
80L-serine metabolic process (GO:0006563)2.85603509
81rRNA metabolic process (GO:0016072)2.85454221
82gamma-aminobutyric acid transport (GO:0015812)2.84906222
83mitotic recombination (GO:0006312)2.84472979
84methionine metabolic process (GO:0006555)2.84410016
85telomere maintenance via telomere lengthening (GO:0010833)2.82461195
86monoubiquitinated protein deubiquitination (GO:0035520)2.81308997
87folic acid transport (GO:0015884)2.79997255
88primary amino compound metabolic process (GO:1901160)2.79813484
89cellular component biogenesis (GO:0044085)2.79720536
90indole-containing compound metabolic process (GO:0042430)2.79383439
91regulation of nuclear cell cycle DNA replication (GO:0033262)2.79275002
92RNA methylation (GO:0001510)2.78487257
93transcription-coupled nucleotide-excision repair (GO:0006283)2.77941657
94tryptophan metabolic process (GO:0006568)2.75892381
95respiratory chain complex IV assembly (GO:0008535)2.73859305
96methionine biosynthetic process (GO:0009086)2.72100905
97nonmotile primary cilium assembly (GO:0035058)2.71879192
98signal peptide processing (GO:0006465)2.71741005
99regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.71318439
100serotonin metabolic process (GO:0042428)2.71180189
101anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.69954706
102DNA ligation (GO:0006266)2.69521211
103sulfur amino acid biosynthetic process (GO:0000097)2.69054898
104chromatin remodeling at centromere (GO:0031055)2.68778160
105regulation of glucokinase activity (GO:0033131)2.68450155
106regulation of hexokinase activity (GO:1903299)2.68450155
107DNA-templated transcription, elongation (GO:0006354)2.68209907
108aminoglycoside antibiotic metabolic process (GO:0030647)2.68003693
109positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.66820786
110replication fork processing (GO:0031297)2.66156707
111behavioral response to ethanol (GO:0048149)2.65708789
112amino sugar catabolic process (GO:0046348)2.64402173
113biotin metabolic process (GO:0006768)2.64028722
114tRNA modification (GO:0006400)2.63903986
115centriole replication (GO:0007099)2.63247550
116sperm motility (GO:0030317)2.62037685
117transcription elongation from RNA polymerase II promoter (GO:0006368)2.62019216
118righting reflex (GO:0060013)2.61941078
119recombinational repair (GO:0000725)2.61079661
120viral mRNA export from host cell nucleus (GO:0046784)2.59824277
121double-strand break repair via homologous recombination (GO:0000724)2.59776429
122negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.59538274
123IMP biosynthetic process (GO:0006188)2.58745150
124regulation of mitochondrial translation (GO:0070129)2.58406747
125regulation of cellular amino acid metabolic process (GO:0006521)2.58203358
126protein polyglutamylation (GO:0018095)2.58097905
127dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.57871590
128spliceosomal snRNP assembly (GO:0000387)2.57405181
129negative regulation of DNA-dependent DNA replication (GO:2000104)2.55658102
130sulfation (GO:0051923)2.53628973
131amino-acid betaine metabolic process (GO:0006577)2.53293549
132reciprocal DNA recombination (GO:0035825)2.53190390
133reciprocal meiotic recombination (GO:0007131)2.53190390
134regulation of spindle organization (GO:0090224)2.52058590
135kidney morphogenesis (GO:0060993)2.51830386
136guanosine-containing compound biosynthetic process (GO:1901070)2.51372137
137kinetochore assembly (GO:0051382)2.51126240
138iron-sulfur cluster assembly (GO:0016226)2.49735014
139metallo-sulfur cluster assembly (GO:0031163)2.49735014
140nephron epithelium morphogenesis (GO:0072088)2.49727355
141nephron tubule morphogenesis (GO:0072078)2.49727355
142amine catabolic process (GO:0009310)2.49556357
143cellular biogenic amine catabolic process (GO:0042402)2.49556357
144spinal cord motor neuron differentiation (GO:0021522)2.46614243
145L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.44969984
146startle response (GO:0001964)2.41240078
147rRNA catabolic process (GO:0016075)2.40979672
148alanine transport (GO:0032328)2.39628000
149transmission of nerve impulse (GO:0019226)2.37454865
150oxidative demethylation (GO:0070989)2.35579539
151negative regulation of synaptic transmission, GABAergic (GO:0032229)2.34660248
152cornea development in camera-type eye (GO:0061303)2.33754645
153meiotic chromosome segregation (GO:0045132)2.32929488
154membrane depolarization during action potential (GO:0086010)2.31049385
155regulation of centriole replication (GO:0046599)2.30986833
156regulation of cilium movement (GO:0003352)2.26448430
157snRNA transcription (GO:0009301)2.25807292
158proline transport (GO:0015824)2.24842179
159regulation of action potential (GO:0098900)2.23113933
160photoreceptor cell maintenance (GO:0045494)2.22863884
161DNA double-strand break processing (GO:0000729)2.22748358
162acrosome reaction (GO:0007340)2.21675036
163neuronal action potential (GO:0019228)2.21655913
164regulation of centrosome duplication (GO:0010824)2.21391225
165epithelial cilium movement (GO:0003351)2.21367707
166cilium organization (GO:0044782)2.20463263
167glutamate receptor signaling pathway (GO:0007215)2.19620924
168cAMP catabolic process (GO:0006198)2.18898857
169NAD biosynthetic process (GO:0009435)2.18290791
170multicellular organism reproduction (GO:0032504)2.17812715
171axoneme assembly (GO:0035082)2.17512256
172protein K48-linked deubiquitination (GO:0071108)2.17348782
173C4-dicarboxylate transport (GO:0015740)2.16401753
174protein import into peroxisome matrix (GO:0016558)2.16386713
175cilium assembly (GO:0042384)2.16082644
176microtubule organizing center organization (GO:0031023)2.15444433
177cellular response to sterol (GO:0036315)2.14366794
178centrosome organization (GO:0051297)2.13486548
179regulation of telomere maintenance (GO:0032204)2.12274264
180negative regulation of transcription regulatory region DNA binding (GO:2000678)2.10777518
181cilium or flagellum-dependent cell motility (GO:0001539)2.10636219
182ncRNA catabolic process (GO:0034661)2.10576649
183limb development (GO:0060173)2.10466468

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.55669513
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.03948019
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.57879147
4EZH2_22144423_ChIP-Seq_EOC_Human3.99392476
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.78195739
6ZNF274_21170338_ChIP-Seq_K562_Hela3.64477656
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.44843559
8VDR_22108803_ChIP-Seq_LS180_Human3.43622953
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.43143117
10GABP_17652178_ChIP-ChIP_JURKAT_Human3.33728519
11CREB1_15753290_ChIP-ChIP_HEK293T_Human3.24547784
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.08004170
13ETS1_20019798_ChIP-Seq_JURKAT_Human3.05058677
14GBX2_23144817_ChIP-Seq_PC3_Human2.83122981
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.77935097
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.74298382
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.69089972
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.67513226
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.64721983
20* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.60700439
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.60288626
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.56522918
23MYC_19030024_ChIP-ChIP_MESCs_Mouse2.50446295
24VDR_23849224_ChIP-Seq_CD4+_Human2.45297430
25CTBP2_25329375_ChIP-Seq_LNCAP_Human2.41869305
26EGR1_23403033_ChIP-Seq_LIVER_Mouse2.36713366
27SALL1_21062744_ChIP-ChIP_HESCs_Human2.35926817
28CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.35840432
29FOXP3_21729870_ChIP-Seq_TREG_Human2.27521354
30ZFP57_27257070_Chip-Seq_ESCs_Mouse2.26265665
31SRF_21415370_ChIP-Seq_HL-1_Mouse2.25919809
32HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.23388991
33SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.22030071
34CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.21978094
35FOXM1_23109430_ChIP-Seq_U2OS_Human2.20065002
36CTBP1_25329375_ChIP-Seq_LNCAP_Human2.18604183
37MYC_19079543_ChIP-ChIP_MESCs_Mouse2.16907204
38EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.13792689
39FUS_26573619_Chip-Seq_HEK293_Human2.13112350
40CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.12708998
41ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.11741223
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.10835065
43EWS_26573619_Chip-Seq_HEK293_Human2.10335457
44* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.97788133
45FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.97487052
46YY1_21170310_ChIP-Seq_MESCs_Mouse1.95334925
47NELFA_20434984_ChIP-Seq_ESCs_Mouse1.94769502
48E2F1_18555785_ChIP-Seq_MESCs_Mouse1.93805701
49HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.93060737
50ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.90364960
51P300_19829295_ChIP-Seq_ESCs_Human1.87560877
52SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.86599793
53NOTCH1_21737748_ChIP-Seq_TLL_Human1.85777633
54POU3F2_20337985_ChIP-ChIP_501MEL_Human1.82951591
55THAP11_20581084_ChIP-Seq_MESCs_Mouse1.82207767
56TAF15_26573619_Chip-Seq_HEK293_Human1.81519776
57GABP_19822575_ChIP-Seq_HepG2_Human1.80890711
58DCP1A_22483619_ChIP-Seq_HELA_Human1.80727850
59SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.78302432
60HOXB4_20404135_ChIP-ChIP_EML_Mouse1.78252863
61ER_23166858_ChIP-Seq_MCF-7_Human1.77829051
62PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75871293
63POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.74918378
64TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.74918378
65AR_21572438_ChIP-Seq_LNCaP_Human1.74371854
66NANOG_18555785_ChIP-Seq_MESCs_Mouse1.73654400
67STAT3_23295773_ChIP-Seq_U87_Human1.70689812
68XRN2_22483619_ChIP-Seq_HELA_Human1.70538993
69POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.70389804
70NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.70143262
71IGF1R_20145208_ChIP-Seq_DFB_Human1.67629984
72CBX2_27304074_Chip-Seq_ESCs_Mouse1.65383366
73PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.63924019
74MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.63146425
75KAP1_22055183_ChIP-Seq_ESCs_Mouse1.61035305
76REST_21632747_ChIP-Seq_MESCs_Mouse1.60353769
77EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.57193554
78MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.56591427
79AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.56225504
80RXR_22158963_ChIP-Seq_LIVER_Mouse1.55938837
81RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.55340256
82PIAS1_25552417_ChIP-Seq_VCAP_Human1.54413218
83MYCN_18555785_ChIP-Seq_MESCs_Mouse1.53871981
84ELK1_19687146_ChIP-ChIP_HELA_Human1.53738231
85BMI1_23680149_ChIP-Seq_NPCS_Mouse1.52845072
86FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.49580468
87TCF4_23295773_ChIP-Seq_U87_Human1.48206031
88YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.47123954
89SMAD4_21799915_ChIP-Seq_A2780_Human1.45926991
90MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.45758409
91CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.45316726
92TTF2_22483619_ChIP-Seq_HELA_Human1.44807544
93IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.43831219
94CBP_20019798_ChIP-Seq_JUKART_Human1.43831219
95ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.42848154
96TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41300718
97E2F1_21310950_ChIP-Seq_MCF-7_Human1.40312202
98* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.39135680
99BCAT_22108803_ChIP-Seq_LS180_Human1.38798197
100AR_21909140_ChIP-Seq_LNCAP_Human1.36659123
101SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36346186
102AR_25329375_ChIP-Seq_VCAP_Human1.35299896
103UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33672926
104PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.31751160
105RNF2_27304074_Chip-Seq_NSC_Mouse1.31665660
106IRF1_19129219_ChIP-ChIP_H3396_Human1.31245393
107PPARA_22158963_ChIP-Seq_LIVER_Mouse1.30839819
108MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.30778972
109* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.30778101
110TP63_19390658_ChIP-ChIP_HaCaT_Human1.29623251
111PADI4_21655091_ChIP-ChIP_MCF-7_Human1.28971004
112ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.26189122
113PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.24098401
114TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23697983
115TCF4_22108803_ChIP-Seq_LS180_Human1.22484757
116SMAD3_21741376_ChIP-Seq_EPCs_Human1.22294762
117TP53_22573176_ChIP-Seq_HFKS_Human1.20661262
118KDM5A_27292631_Chip-Seq_BREAST_Human1.20515321
119NR3C1_21868756_ChIP-Seq_MCF10A_Human1.19343361
120RUNX2_22187159_ChIP-Seq_PCA_Human1.18438820
121KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18434453
122SMAD4_21741376_ChIP-Seq_EPCs_Human1.18321137
123CIITA_25753668_ChIP-Seq_RAJI_Human1.18038596
124* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.16538341
125PCGF2_27294783_Chip-Seq_NPCs_Mouse1.13818184
126HOXB7_26014856_ChIP-Seq_BT474_Human1.13340207
127TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.13338816
128TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.11112817
129POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.09987840
130EZH2_27304074_Chip-Seq_ESCs_Mouse1.08187898
131ELK1_22589737_ChIP-Seq_MCF10A_Human1.07673956
132FLI1_27457419_Chip-Seq_LIVER_Mouse1.06678626
133EED_16625203_ChIP-ChIP_MESCs_Mouse1.06543600
134NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.04378605
135GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03645529
136NANOG_19829295_ChIP-Seq_ESCs_Human1.03572473
137SOX2_19829295_ChIP-Seq_ESCs_Human1.03572473
138BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.03040332
139PRDM14_20953172_ChIP-Seq_ESCs_Human1.02478747
140GATA3_21878914_ChIP-Seq_MCF-7_Human1.02047957
141MYC_18940864_ChIP-ChIP_HL60_Human1.01371813
142JARID2_20064375_ChIP-Seq_MESCs_Mouse1.00077747
143FOXA1_25329375_ChIP-Seq_VCAP_Human0.99898582
144FOXA1_27270436_Chip-Seq_PROSTATE_Human0.99898582
145POU5F1_16153702_ChIP-ChIP_HESCs_Human0.99300135
146HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.98473951
147SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.98170489
148SMAD3_21741376_ChIP-Seq_ESCs_Human0.97860400
149ETV2_25802403_ChIP-Seq_MESCs_Mouse0.97666763
150DROSHA_22980978_ChIP-Seq_HELA_Human0.97493986
151REST_18959480_ChIP-ChIP_MESCs_Mouse0.97378170
152NCOR_22424771_ChIP-Seq_293T_Human0.96674030
153TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96225343
154CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96025247
155STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.95708804
156GATA1_22025678_ChIP-Seq_K562_Human0.95666431
157PCGF2_27294783_Chip-Seq_ESCs_Mouse0.95416738
158BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.93783451
159OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93403577
160KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.93248034
161EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.93156593
162SOX2_21211035_ChIP-Seq_LN229_Gbm0.92660085
163ARNT_22903824_ChIP-Seq_MCF-7_Human0.91111627
164WDR5_24793694_ChIP-Seq_LNCAP_Human0.91042763
165ZFX_18555785_ChIP-Seq_MESCs_Mouse0.90331051
166IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.89857168
167STAT3_1855785_ChIP-Seq_MESCs_Mouse0.89499156
168JUN_21703547_ChIP-Seq_K562_Human0.88057433
169FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.87463516
170SPI1_23547873_ChIP-Seq_NB4_Human0.84085600
171* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.83450743
172NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.79397250
173POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.79353383
174SOX2_18555785_ChIP-Seq_MESCs_Mouse0.77944993
175IRF8_22096565_ChIP-ChIP_GC-B_Human0.75433699
176E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.74217047
177ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.74185376
178NFE2_27457419_Chip-Seq_LIVER_Mouse0.72984297
179PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.72307126
180* LXR_22158963_ChIP-Seq_LIVER_Mouse0.71753263
181GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.71220354
182SUZ12_27294783_Chip-Seq_NPCs_Mouse0.69888890
183SOX17_20123909_ChIP-Seq_XEN_Mouse0.69447285

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.00210027
2MP0002139_abnormal_hepatobiliary_system3.93382129
3MP0003718_maternal_effect3.43121044
4MP0009697_abnormal_copulation2.75662496
5MP0005365_abnormal_bile_salt2.65516172
6MP0005085_abnormal_gallbladder_physiolo2.62882763
7MP0010094_abnormal_chromosome_stability2.54213562
8MP0003111_abnormal_nucleus_morphology2.53987166
9MP0009379_abnormal_foot_pigmentation2.38536725
10MP0003136_yellow_coat_color2.34985376
11MP0006292_abnormal_olfactory_placode2.33775747
12MP0003806_abnormal_nucleotide_metabolis2.33559188
13MP0004381_abnormal_hair_follicle2.33274606
14MP0005360_urolithiasis2.33066670
15MP0003786_premature_aging2.31144137
16MP0008058_abnormal_DNA_repair2.25552022
17MP0008260_abnormal_autophagy2.13097755
18MP0008007_abnormal_cellular_replicative2.11600235
19MP0000569_abnormal_digit_pigmentation2.09053810
20MP0009046_muscle_twitch2.07825686
21MP0003890_abnormal_embryonic-extraembry2.07111326
22MP0004957_abnormal_blastocyst_morpholog2.06335585
23MP0001968_abnormal_touch/_nociception2.05887665
24MP0001764_abnormal_homeostasis2.05257641
25MP0003077_abnormal_cell_cycle2.02705219
26MP0008057_abnormal_DNA_replication2.02037612
27MP0002132_abnormal_respiratory_system2.01715548
28MP0005551_abnormal_eye_electrophysiolog1.95150159
29MP0005075_abnormal_melanosome_morpholog1.94093929
30MP0001485_abnormal_pinna_reflex1.90558333
31MP0002009_preneoplasia1.89884588
32MP0009840_abnormal_foam_cell1.86853339
33MP0005377_hearing/vestibular/ear_phenot1.83469656
34MP0003878_abnormal_ear_physiology1.83469656
35MP0001188_hyperpigmentation1.81993425
36MP0009745_abnormal_behavioral_response1.79905168
37MP0002396_abnormal_hematopoietic_system1.78714581
38MP0002876_abnormal_thyroid_physiology1.75786361
39MP0009333_abnormal_splenocyte_physiolog1.67755483
40MP0003646_muscle_fatigue1.67410202
41MP0000372_irregular_coat_pigmentation1.66175779
42MP0005332_abnormal_amino_acid1.64981047
43MP0002272_abnormal_nervous_system1.62813608
44MP0005410_abnormal_fertilization1.61852149
45MP0000631_abnormal_neuroendocrine_gland1.61055539
46MP0005646_abnormal_pituitary_gland1.60800908
47MP0008872_abnormal_physiological_respon1.57939264
48MP0002736_abnormal_nociception_after1.57688260
49MP0005645_abnormal_hypothalamus_physiol1.57383738
50MP0005451_abnormal_body_composition1.56016437
51MP0008875_abnormal_xenobiotic_pharmacok1.55872144
52MP0003880_abnormal_central_pattern1.53633985
53MP0005409_darkened_coat_color1.53206796
54MP0004043_abnormal_pH_regulation1.51242587
55MP0004019_abnormal_vitamin_homeostasis1.50365927
56MP0006276_abnormal_autonomic_nervous1.46054506
57MP0001501_abnormal_sleep_pattern1.45167741
58MP0004142_abnormal_muscle_tone1.42404587
59MP0000015_abnormal_ear_pigmentation1.42336372
60MP0003787_abnormal_imprinting1.40769739
61MP0002102_abnormal_ear_morphology1.39779385
62MP0004133_heterotaxia1.38354664
63MP0003186_abnormal_redox_activity1.37865297
64MP0006072_abnormal_retinal_apoptosis1.35717897
65MP0001986_abnormal_taste_sensitivity1.35534152
66MP0003937_abnormal_limbs/digits/tail_de1.32401023
67MP0002572_abnormal_emotion/affect_behav1.30954806
68MP0005395_other_phenotype1.30925883
69MP0002557_abnormal_social/conspecific_i1.28566031
70MP0000566_synostosis1.26384750
71MP0004782_abnormal_surfactant_physiolog1.25827153
72MP0002064_seizures1.25719361
73MP0005670_abnormal_white_adipose1.25451238
74MP0003011_delayed_dark_adaptation1.24569155
75MP0001919_abnormal_reproductive_system1.24485270
76MP0001529_abnormal_vocalization1.24272939
77MP0004885_abnormal_endolymph1.24118351
78MP0002160_abnormal_reproductive_system1.23283551
79MP0001486_abnormal_startle_reflex1.23016731
80MP0002095_abnormal_skin_pigmentation1.22746640
81MP0004742_abnormal_vestibular_system1.22308163
82MP0005253_abnormal_eye_physiology1.22005171
83MP0002735_abnormal_chemical_nociception1.21819697
84MP0003119_abnormal_digestive_system1.20794453
85MP0005389_reproductive_system_phenotype1.19858111
86MP0000427_abnormal_hair_cycle1.19730486
87MP0003698_abnormal_male_reproductive1.19470515
88MP0001542_abnormal_bone_strength1.18608207
89MP0003635_abnormal_synaptic_transmissio1.17715440
90MP0010329_abnormal_lipoprotein_level1.16994027
91MP0005647_abnormal_sex_gland1.16423526
92MP0000778_abnormal_nervous_system1.15384565
93MP0001119_abnormal_female_reproductive1.15056704
94MP0005423_abnormal_somatic_nervous1.13517445
95MP0002067_abnormal_sensory_capabilities1.12385194
96MP0003941_abnormal_skin_development1.10949822
97MP0002733_abnormal_thermal_nociception1.10579811
98MP0006036_abnormal_mitochondrial_physio1.10068916
99MP0003283_abnormal_digestive_organ1.08744208
100MP0001929_abnormal_gametogenesis1.07104501
101MP0003195_calcinosis1.07048639
102MP0008932_abnormal_embryonic_tissue1.06225801
103MP0002653_abnormal_ependyma_morphology1.05947329
104MP0002184_abnormal_innervation1.05864455
105MP0005408_hypopigmentation1.04602760
106MP0002638_abnormal_pupillary_reflex1.03509980
107MP0002234_abnormal_pharynx_morphology1.03340142
108MP0002163_abnormal_gland_morphology1.02666708
109MP0002063_abnormal_learning/memory/cond1.02267463
110MP0005319_abnormal_enzyme/_coenzyme1.00067790
111MP0000609_abnormal_liver_physiology0.98715290
112MP0001970_abnormal_pain_threshold0.98574924
113MP0000490_abnormal_crypts_of0.97948398
114MP0005386_behavior/neurological_phenoty0.96953200
115MP0004924_abnormal_behavior0.96953200
116MP0002210_abnormal_sex_determination0.96181757
117MP0003315_abnormal_perineum_morphology0.94841040
118MP0005187_abnormal_penis_morphology0.94830311
119MP0005379_endocrine/exocrine_gland_phen0.94324770
120MP0003656_abnormal_erythrocyte_physiolo0.94233845
121MP0005084_abnormal_gallbladder_morpholo0.91698903
122MP0003868_abnormal_feces_composition0.91423360
123MP0003879_abnormal_hair_cell0.90123129
124MP0002277_abnormal_respiratory_mucosa0.89994611
125MP0006035_abnormal_mitochondrial_morpho0.89611699
126MP0001984_abnormal_olfaction0.89588464
127MP0003763_abnormal_thymus_physiology0.88824632
128MP0002752_abnormal_somatic_nervous0.88796091
129MP0003567_abnormal_fetal_cardiomyocyte0.88717610
130MP0003121_genomic_imprinting0.88570290
131MP0000049_abnormal_middle_ear0.85386257
132MP0003252_abnormal_bile_duct0.84854185
133MP0000026_abnormal_inner_ear0.84583301
134MP0000955_abnormal_spinal_cord0.83708762
135MP0001661_extended_life_span0.83658887
136MP0000383_abnormal_hair_follicle0.83568986
137MP0005195_abnormal_posterior_eye0.82740846
138MP0005174_abnormal_tail_pigmentation0.82244635
139MP0001293_anophthalmia0.82061990
140MP0003724_increased_susceptibility_to0.81251447
141MP0008995_early_reproductive_senescence0.80969630
142MP0002734_abnormal_mechanical_nocicepti0.79924909
143MP0010386_abnormal_urinary_bladder0.79651557
144MP0000681_abnormal_thyroid_gland0.79132593
145MP0008961_abnormal_basal_metabolism0.78893439
146MP0001944_abnormal_pancreas_morphology0.78105543
147MP0001324_abnormal_eye_pigmentation0.77817429
148MP0003861_abnormal_nervous_system0.77764806
149MP0005171_absent_coat_pigmentation0.75786140
150MP0000689_abnormal_spleen_morphology0.74012817
151MP0000653_abnormal_sex_gland0.73273755
152MP0002882_abnormal_neuron_morphology0.73234731
153MP0001286_abnormal_eye_development0.73224545
154MP0004147_increased_porphyrin_level0.72348703
155MP0000598_abnormal_liver_morphology0.72083785
156MP0003938_abnormal_ear_development0.71288691
157MP0001145_abnormal_male_reproductive0.70755626
158MP0001186_pigmentation_phenotype0.69847769
159MP0008877_abnormal_DNA_methylation0.69677212
160MP0003699_abnormal_female_reproductive0.69502183
161MP0005636_abnormal_mineral_homeostasis0.67941411
162MP0000350_abnormal_cell_proliferation0.65934715
163MP0002938_white_spotting0.65109737
164MP0002166_altered_tumor_susceptibility0.62682877
165MP0008469_abnormal_protein_level0.61992809
166MP0002118_abnormal_lipid_homeostasis0.61500461
167MP0002075_abnormal_coat/hair_pigmentati0.60581034
168MP0002722_abnormal_immune_system0.60503593
169MP0005397_hematopoietic_system_phenotyp0.60411843
170MP0001545_abnormal_hematopoietic_system0.60411843
171MP0002019_abnormal_tumor_incidence0.59974504

Predicted human phenotypes

RankGene SetZ-score
1Hyperglycinemia (HP:0002154)4.86733158
2Hyperglycinuria (HP:0003108)4.28506144
3Reduced antithrombin III activity (HP:0001976)3.82380247
4Birth length less than 3rd percentile (HP:0003561)3.68225779
5Abnormality of serine family amino acid metabolism (HP:0010894)3.61671428
6Abnormality of glycine metabolism (HP:0010895)3.61671428
7Type I transferrin isoform profile (HP:0003642)3.60950774
8Molar tooth sign on MRI (HP:0002419)3.48693004
9Abnormality of midbrain morphology (HP:0002418)3.48693004
10Genetic anticipation (HP:0003743)3.33385665
11Prolonged partial thromboplastin time (HP:0003645)3.26706684
12Breast hypoplasia (HP:0003187)3.23042202
13Abnormality of serum amino acid levels (HP:0003112)3.18911251
14Congenital stationary night blindness (HP:0007642)3.12409824
15Impulsivity (HP:0100710)3.03140427
163-Methylglutaconic aciduria (HP:0003535)2.95942178
17Gaze-evoked nystagmus (HP:0000640)2.94975985
18Progressive cerebellar ataxia (HP:0002073)2.94353630
19Nephronophthisis (HP:0000090)2.94311777
20Hyperventilation (HP:0002883)2.93257901
21Capillary hemangiomas (HP:0005306)2.83301297
22Type II lissencephaly (HP:0007260)2.76031906
23Attenuation of retinal blood vessels (HP:0007843)2.68725799
24Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.67999510
25Abnormality of the renal cortex (HP:0011035)2.64790257
26Pendular nystagmus (HP:0012043)2.64786306
27Pancreatic cysts (HP:0001737)2.64391752
28Chromosomal breakage induced by crosslinking agents (HP:0003221)2.64305009
29Protruding tongue (HP:0010808)2.63969097
30Abnormality of the renal medulla (HP:0100957)2.60629265
31Cystic liver disease (HP:0006706)2.60278901
32Sclerocornea (HP:0000647)2.51923583
33Abnormality of pyrimidine metabolism (HP:0004353)2.47236935
34Chromsome breakage (HP:0040012)2.45299746
35Carpal bone hypoplasia (HP:0001498)2.42565816
36Patellar aplasia (HP:0006443)2.39902032
37Renal cortical cysts (HP:0000803)2.38845238
38Tubular atrophy (HP:0000092)2.38090089
39Pancreatic fibrosis (HP:0100732)2.36546133
40Dicarboxylic aciduria (HP:0003215)2.35997616
41Abnormality of dicarboxylic acid metabolism (HP:0010995)2.35997616
42Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.34868316
43Aplasia/Hypoplasia of the patella (HP:0006498)2.34710694
44Abnormality of the preputium (HP:0100587)2.33787741
45Abnormality of monocarboxylic acid metabolism (HP:0010996)2.32481717
46Aplasia/Hypoplasia involving the musculature (HP:0001460)2.29805106
47Lethargy (HP:0001254)2.27838238
48Inability to walk (HP:0002540)2.27158704
49Chronic hepatic failure (HP:0100626)2.27139490
50Clumsiness (HP:0002312)2.26396892
51Abolished electroretinogram (ERG) (HP:0000550)2.25480499
52Abnormal spermatogenesis (HP:0008669)2.25314806
53Meckel diverticulum (HP:0002245)2.25169894
54Sparse eyelashes (HP:0000653)2.23430501
55Abnormal protein glycosylation (HP:0012346)2.21847759
56Abnormal glycosylation (HP:0012345)2.21847759
57Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.21847759
58Abnormal protein N-linked glycosylation (HP:0012347)2.21847759
59Broad-based gait (HP:0002136)2.19958461
60Absent rod-and cone-mediated responses on ERG (HP:0007688)2.19720893
61Hypoplasia of the pons (HP:0012110)2.17992922
62Cerebellar dysplasia (HP:0007033)2.17777909
63Rough bone trabeculation (HP:0100670)2.17695820
64Large for gestational age (HP:0001520)2.17359615
65Hepatic necrosis (HP:0002605)2.17096984
66Abnormality of the labia minora (HP:0012880)2.16966937
67Abnormal drinking behavior (HP:0030082)2.15714400
68Polydipsia (HP:0001959)2.15714400
69Abnormality of aromatic amino acid family metabolism (HP:0004338)2.15436692
70Abnormality of fatty-acid metabolism (HP:0004359)2.14945687
71Bony spicule pigmentary retinopathy (HP:0007737)2.14171800
72Gout (HP:0001997)2.13696347
73Megaloblastic anemia (HP:0001889)2.12296364
74Abnormality of the pons (HP:0007361)2.12119527
75Abnormality of secondary sexual hair (HP:0009888)2.10728364
76Abnormality of the axillary hair (HP:0100134)2.10728364
77Medial flaring of the eyebrow (HP:0010747)2.10198763
78Type 2 muscle fiber atrophy (HP:0003554)2.09360281
79Abnormality of the ileum (HP:0001549)2.08602099
80Prolonged neonatal jaundice (HP:0006579)2.08535227
81Microvesicular hepatic steatosis (HP:0001414)2.08081579
82Increased hepatocellular lipid droplets (HP:0006565)2.07897574
83Azoospermia (HP:0000027)2.07817468
84Lipid accumulation in hepatocytes (HP:0006561)2.07608163
85Intrahepatic cholestasis (HP:0001406)2.05422220
86Increased serum lactate (HP:0002151)2.04961789
87Respiratory difficulties (HP:0002880)2.04934807
88Entropion (HP:0000621)2.04017168
89Joint hemorrhage (HP:0005261)2.03814145
90Progressive muscle weakness (HP:0003323)2.01884706
91Abnormality of the prostate (HP:0008775)2.01163759
92Febrile seizures (HP:0002373)2.00613709
93Secondary amenorrhea (HP:0000869)2.00592139
94Lissencephaly (HP:0001339)2.00514254
95Abnormality of methionine metabolism (HP:0010901)2.00237047
96Microretrognathia (HP:0000308)1.99815978
97Bone marrow hypocellularity (HP:0005528)1.99679595
98Methylmalonic acidemia (HP:0002912)1.99545944
99Generalized aminoaciduria (HP:0002909)1.99343375
100Furrowed tongue (HP:0000221)1.98403384
101Cheilitis (HP:0100825)1.98110701
102Hyperammonemia (HP:0001987)1.98086391
103Ectopic kidney (HP:0000086)1.97714671
104Progressive inability to walk (HP:0002505)1.97067953
105Intestinal atresia (HP:0011100)1.96969912
106Anencephaly (HP:0002323)1.95766428
107Aplastic anemia (HP:0001915)1.95108877
108Aplasia/Hypoplasia of the tibia (HP:0005772)1.94773721
109Abnormality of chromosome stability (HP:0003220)1.94744973
110Abnormality of male internal genitalia (HP:0000022)1.94619003
111Cerebral hypomyelination (HP:0006808)1.94330932
112Decreased central vision (HP:0007663)1.93550363
113Dynein arm defect of respiratory motile cilia (HP:0012255)1.93243328
114Absent/shortened dynein arms (HP:0200106)1.93243328
115Hypobetalipoproteinemia (HP:0003563)1.92429018
116Methylmalonic aciduria (HP:0012120)1.89393650
117Congenital, generalized hypertrichosis (HP:0004540)1.89203818
118Small hand (HP:0200055)1.89028117
119Abnormality of dental color (HP:0011073)1.88778353
120Rib fusion (HP:0000902)1.88614985
121Retinal dysplasia (HP:0007973)1.88232129
122Abnormality of urine glucose concentration (HP:0011016)1.87799041
123Glycosuria (HP:0003076)1.87799041
124Pustule (HP:0200039)1.87782683
125Aplasia/hypoplasia of the uterus (HP:0008684)1.87563843
126Conjugated hyperbilirubinemia (HP:0002908)1.86957731
127Concave nail (HP:0001598)1.85706294
128Death in infancy (HP:0001522)1.85014313
129Hepatocellular necrosis (HP:0001404)1.84659993
130Preaxial hand polydactyly (HP:0001177)1.84335725
131Alopecia of scalp (HP:0002293)1.84270408
132Hypothermia (HP:0002045)1.83792548
133Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.82826208
134Abnormality of alanine metabolism (HP:0010916)1.82826208
135Hyperalaninemia (HP:0003348)1.82826208
136Pancytopenia (HP:0001876)1.82773616
137Abnormality of aspartate family amino acid metabolism (HP:0010899)1.82082967
138Aplasia/Hypoplasia of the uvula (HP:0010293)1.80801751
139Dandy-Walker malformation (HP:0001305)1.80651425
140Hypoplasia of the radius (HP:0002984)1.79365677
141Abnormal number of erythroid precursors (HP:0012131)1.78191057
142Reticulocytopenia (HP:0001896)1.78174980
143Renal Fanconi syndrome (HP:0001994)1.77991283
144Clubbing of toes (HP:0100760)1.77731038
145Muscle fiber atrophy (HP:0100295)1.77359968
146Abnormality of DNA repair (HP:0003254)1.77357587
147Nausea (HP:0002018)1.76933998
148Polyuria (HP:0000103)1.76861352
149Encephalitis (HP:0002383)1.76804723
150Fair hair (HP:0002286)1.76798589
151Abnormal rod and cone electroretinograms (HP:0008323)1.76629675
152Oral leukoplakia (HP:0002745)1.76346138
153Optic nerve hypoplasia (HP:0000609)1.75975852
154Homocystinuria (HP:0002156)1.74033347
155Abnormality of homocysteine metabolism (HP:0010919)1.74033347
156Parakeratosis (HP:0001036)1.73734854
157Aplasia/Hypoplasia of the tongue (HP:0010295)1.73303644
158Oligodactyly (hands) (HP:0001180)1.73122247
159True hermaphroditism (HP:0010459)1.72704981
160Bilateral microphthalmos (HP:0007633)1.72182317
161Duplicated collecting system (HP:0000081)1.70876748
162Gastrointestinal atresia (HP:0002589)1.69955052
163Abnormality of the renal collecting system (HP:0004742)1.69886460
164Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.69619356
165Male pseudohermaphroditism (HP:0000037)1.69333682
166Severe muscular hypotonia (HP:0006829)1.69210139
167Congenital hepatic fibrosis (HP:0002612)1.67310728
168Abnormal biliary tract physiology (HP:0012439)1.64965893
169Bile duct proliferation (HP:0001408)1.64965893
170Gait imbalance (HP:0002141)1.63858556
171Absent thumb (HP:0009777)1.63822846
172Chorioretinal atrophy (HP:0000533)1.63449654
173Highly arched eyebrow (HP:0002553)1.62907538
174Hemiparesis (HP:0001269)1.62763369
175Sloping forehead (HP:0000340)1.61496912
176Aplasia involving forearm bones (HP:0009822)1.61458300
177Absent forearm bone (HP:0003953)1.61458300
178Absent radius (HP:0003974)1.61246165
179Increased corneal curvature (HP:0100692)1.60999684
180Keratoconus (HP:0000563)1.60999684
181Confusion (HP:0001289)1.60550239
182Postaxial foot polydactyly (HP:0001830)1.60528954

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.24078547
2AKT33.69800566
3STK163.10457118
4IRAK33.08283511
5WEE12.97923543
6MKNK22.89984437
7SRPK12.78236607
8PLK42.65855966
9WNK42.64771757
10PNCK2.61536582
11EIF2AK12.55366517
12ZAK2.41152773
13WNK32.34447776
14MKNK12.25361829
15EIF2AK32.24249031
16INSRR2.16517206
17CASK2.14834453
18MUSK2.06223823
19BRSK22.01867575
20TSSK62.00733472
21NME21.98889654
22STK38L1.96042078
23CAMK1D1.88913342
24BCKDK1.74651740
25EPHA21.72326930
26CAMK1G1.69519975
27TNIK1.67472999
28IRAK41.66520084
29PINK11.61058123
30MAPK131.58231633
31EIF2AK21.51618521
32ACVR1B1.51228511
33TRIM281.48517109
34STK391.43988789
35LATS11.42704788
36OXSR11.36925669
37PIM21.35260602
38PLK31.32469461
39PLK11.30332001
40VRK11.27621858
41YES11.23458675
42MAP3K41.20180539
43TXK1.14396569
44SIK31.12207692
45DYRK31.11193507
46STK241.10097212
47NEK21.08258124
48TAF11.06928909
49MAP4K21.06326629
50NLK1.05448677
51CDK121.04480407
52NTRK31.03941180
53TGFBR11.02695185
54PRKCG1.00798833
55FGFR21.00279847
56PAK30.99908334
57CAMKK20.98854594
58BRSK10.98096287
59TTK0.97479616
60CDK70.96496659
61SIK20.95350505
62ADRBK10.93295708
63CDK80.87104200
64PIM10.86361539
65CLK10.85681813
66CHEK20.85353916
67TEC0.83653322
68PASK0.83393224
69NME10.81295316
70PIK3CG0.80492446
71DAPK20.78863842
72AURKB0.78247265
73MAP2K70.74769746
74PRKCE0.74573043
75IRAK20.73490739
76BRAF0.73472259
77KIT0.72902590
78STK40.72899826
79CCNB10.72306757
80CDK30.72174388
81SGK20.71257308
82TLK10.69402552
83MAPKAPK50.69155421
84VRK20.68891462
85STK30.68675784
86PRPF4B0.68655025
87NEK10.65730030
88CDC70.65668471
89PDK20.65569837
90CAMK10.65453635
91BRD40.64279455
92ATR0.63329864
93CSNK2A10.62518092
94AURKA0.61737907
95ATM0.59662184
96NUAK10.59146500
97EEF2K0.59145913
98FRK0.57898386
99IKBKB0.57280285
100PLK20.56937288
101MARK30.56423389
102MAPK40.56343085
103CSNK1G10.56095321
104SIK10.55389353
105IRAK10.55157770
106CSNK1E0.52483944
107WNK10.52260787
108MARK10.51123462
109PRKAA10.50920817
110CDK40.50238719
111CSNK2A20.49750600
112RPS6KC10.48776282
113RPS6KL10.48776282
114TYRO30.48742746
115NTRK20.46915752
116TAOK30.45988103
117PRKCI0.45874745
118BMPR1B0.45864840
119DYRK20.45539215
120ADRBK20.45370871
121GRK70.44857879
122CSNK1G30.44026302
123NEK60.43418816
124PHKG10.43201134
125PHKG20.43201134
126LYN0.42360866
127RPS6KA60.42084259
128CDK10.41146167
129RPS6KA40.40899308
130CSNK1A10.40702224
131BCR0.40700227
132MAPK150.40486448
133GSK3B0.40044327
134FLT30.39823930
135PTK2B0.38617383
136PDK40.37910006
137PDK30.37910006
138SGK2230.37507395
139SGK4940.37507395
140ABL20.37297329
141RPS6KB10.37160622
142PIK3CA0.37011069
143MAPK110.36996318
144GRK10.36560487
145CSF1R0.36374714
146PRKCQ0.36171294
147STK110.36089049
148CSNK1D0.36042691
149TAOK20.35506937
150CHEK10.35238908
151PRKAA20.34507183
152RPS6KA50.34138880
153MAPK140.34120488
154MAP3K140.34002164
155STK380.33927371
156CDK20.32524839
157NEK90.32439784
158CAMK2A0.32368102
159PRKACA0.31643792

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007503.36938330
2RNA polymerase_Homo sapiens_hsa030203.17383223
3DNA replication_Homo sapiens_hsa030302.84839741
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.78521309
5Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.48379324
6Nicotine addiction_Homo sapiens_hsa050332.37874994
7Mismatch repair_Homo sapiens_hsa034302.36034655
8Proteasome_Homo sapiens_hsa030502.34710865
9Folate biosynthesis_Homo sapiens_hsa007902.29181190
10Homologous recombination_Homo sapiens_hsa034402.26254577
11Pyrimidine metabolism_Homo sapiens_hsa002402.25930815
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.22592629
13Ribosome_Homo sapiens_hsa030102.06903274
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.04755320
15One carbon pool by folate_Homo sapiens_hsa006702.04403402
16Nitrogen metabolism_Homo sapiens_hsa009101.94955735
17Drug metabolism - other enzymes_Homo sapiens_hsa009831.94540518
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.86684545
19Linoleic acid metabolism_Homo sapiens_hsa005911.77241943
20Basal transcription factors_Homo sapiens_hsa030221.76041909
21Spliceosome_Homo sapiens_hsa030401.74035581
22Base excision repair_Homo sapiens_hsa034101.73872398
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.70695694
24Primary bile acid biosynthesis_Homo sapiens_hsa001201.70074413
25Nucleotide excision repair_Homo sapiens_hsa034201.65319771
26RNA transport_Homo sapiens_hsa030131.64258177
27Fanconi anemia pathway_Homo sapiens_hsa034601.62490524
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.61330842
29Taste transduction_Homo sapiens_hsa047421.53970883
30Pentose and glucuronate interconversions_Homo sapiens_hsa000401.52543105
31Fatty acid elongation_Homo sapiens_hsa000621.50036518
32Pentose phosphate pathway_Homo sapiens_hsa000301.47605387
33Regulation of autophagy_Homo sapiens_hsa041401.47245865
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.47169489
35Fatty acid biosynthesis_Homo sapiens_hsa000611.46069424
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.39294741
37Cell cycle_Homo sapiens_hsa041101.38824853
38Sulfur relay system_Homo sapiens_hsa041221.37155284
39Purine metabolism_Homo sapiens_hsa002301.36601185
40Vitamin digestion and absorption_Homo sapiens_hsa049771.34387884
41Morphine addiction_Homo sapiens_hsa050321.33760490
42Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.32625781
43Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.32408878
44Selenocompound metabolism_Homo sapiens_hsa004501.27809975
45Steroid hormone biosynthesis_Homo sapiens_hsa001401.26867878
46Lysine degradation_Homo sapiens_hsa003101.26425853
47Protein export_Homo sapiens_hsa030601.25523633
48Caffeine metabolism_Homo sapiens_hsa002321.24660073
49Peroxisome_Homo sapiens_hsa041461.23670974
50Olfactory transduction_Homo sapiens_hsa047401.23078659
51Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.22839645
52Cysteine and methionine metabolism_Homo sapiens_hsa002701.22490874
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.21105236
54Glutamatergic synapse_Homo sapiens_hsa047241.18496033
55Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.17518004
56Retinol metabolism_Homo sapiens_hsa008301.17338434
57GABAergic synapse_Homo sapiens_hsa047271.16658645
58Cyanoamino acid metabolism_Homo sapiens_hsa004601.13293908
59Ether lipid metabolism_Homo sapiens_hsa005651.10722455
60Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.09808797
61beta-Alanine metabolism_Homo sapiens_hsa004101.08842004
62RNA degradation_Homo sapiens_hsa030181.07691573
63Insulin secretion_Homo sapiens_hsa049111.07298095
64Fatty acid degradation_Homo sapiens_hsa000711.05176396
65Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.04049785
66Tryptophan metabolism_Homo sapiens_hsa003801.03608856
67Biosynthesis of amino acids_Homo sapiens_hsa012301.02890452
68Circadian entrainment_Homo sapiens_hsa047130.99865080
69Propanoate metabolism_Homo sapiens_hsa006400.98545232
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.98462844
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.96102352
72p53 signaling pathway_Homo sapiens_hsa041150.93528065
73Serotonergic synapse_Homo sapiens_hsa047260.93165435
74Butanoate metabolism_Homo sapiens_hsa006500.89873537
75Oxidative phosphorylation_Homo sapiens_hsa001900.85866993
76Metabolic pathways_Homo sapiens_hsa011000.85235781
772-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.84437055
78Maturity onset diabetes of the young_Homo sapiens_hsa049500.83381694
79Non-homologous end-joining_Homo sapiens_hsa034500.82899607
80Steroid biosynthesis_Homo sapiens_hsa001000.82454607
81Carbon metabolism_Homo sapiens_hsa012000.82098424
82Fatty acid metabolism_Homo sapiens_hsa012120.79228124
83Arginine and proline metabolism_Homo sapiens_hsa003300.78882134
84Chemical carcinogenesis_Homo sapiens_hsa052040.74730711
85Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.74708021
86Glutathione metabolism_Homo sapiens_hsa004800.74225783
87Complement and coagulation cascades_Homo sapiens_hsa046100.73693275
88Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.73652172
89Arginine biosynthesis_Homo sapiens_hsa002200.72052919
90Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.71845180
91Histidine metabolism_Homo sapiens_hsa003400.68905372
92Basal cell carcinoma_Homo sapiens_hsa052170.67972590
93Calcium signaling pathway_Homo sapiens_hsa040200.67014537
94Arachidonic acid metabolism_Homo sapiens_hsa005900.66700532
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65400312
96Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.64076785
97Glycerophospholipid metabolism_Homo sapiens_hsa005640.62420478
98Fructose and mannose metabolism_Homo sapiens_hsa000510.61473780
99Hedgehog signaling pathway_Homo sapiens_hsa043400.60817949
100Epstein-Barr virus infection_Homo sapiens_hsa051690.60325964
101Ovarian steroidogenesis_Homo sapiens_hsa049130.59304284
102Cardiac muscle contraction_Homo sapiens_hsa042600.59300270
103Cholinergic synapse_Homo sapiens_hsa047250.57583057
104Starch and sucrose metabolism_Homo sapiens_hsa005000.55807234
105Long-term depression_Homo sapiens_hsa047300.54871414
106Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.54376830
107Dopaminergic synapse_Homo sapiens_hsa047280.53493016
108Hippo signaling pathway_Homo sapiens_hsa043900.52752890
109Herpes simplex infection_Homo sapiens_hsa051680.52263065
110Bile secretion_Homo sapiens_hsa049760.51799264
111Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51754200
112Parkinsons disease_Homo sapiens_hsa050120.50649496
113Cocaine addiction_Homo sapiens_hsa050300.47017843
114Other glycan degradation_Homo sapiens_hsa005110.45511618
115Salivary secretion_Homo sapiens_hsa049700.45220583
116Primary immunodeficiency_Homo sapiens_hsa053400.45083246
117Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.44821707
118PPAR signaling pathway_Homo sapiens_hsa033200.43857914
119Tyrosine metabolism_Homo sapiens_hsa003500.42904214
120Phenylalanine metabolism_Homo sapiens_hsa003600.42010327
121Vascular smooth muscle contraction_Homo sapiens_hsa042700.41195309
122Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40974206
123cAMP signaling pathway_Homo sapiens_hsa040240.40764786
124Oxytocin signaling pathway_Homo sapiens_hsa049210.40427115
125Glycerolipid metabolism_Homo sapiens_hsa005610.40094989
126Staphylococcus aureus infection_Homo sapiens_hsa051500.39162777
127Sulfur metabolism_Homo sapiens_hsa009200.38681741
128N-Glycan biosynthesis_Homo sapiens_hsa005100.36796451
129Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.35813052
130Sphingolipid metabolism_Homo sapiens_hsa006000.35583986
131Galactose metabolism_Homo sapiens_hsa000520.34944451
132Measles_Homo sapiens_hsa051620.32752290
133Huntingtons disease_Homo sapiens_hsa050160.32557266
134Fat digestion and absorption_Homo sapiens_hsa049750.31634113
135Pyruvate metabolism_Homo sapiens_hsa006200.31273259
136Phototransduction_Homo sapiens_hsa047440.30655240
137Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30493397
138ABC transporters_Homo sapiens_hsa020100.30464840

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »