PDK3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle, and thus is one of the major enzymes responsible for the regulation of glucose metabolism. The enzymatic activity of PDH is regulated by a phosphorylation/dephosphorylation cycle, and phosphorylation results in inactivation of PDH. The protein encoded by this gene is one of the three pyruvate dehydrogenase kinases that inhibits the PDH complex by phosphorylation of the E1 alpha subunit. This gene is predominantly expressed in the heart and skeletal muscles. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)5.07949554
2telomere maintenance via semi-conservative replication (GO:0032201)5.07817274
3DNA deamination (GO:0045006)4.99045030
4ribosomal small subunit assembly (GO:0000028)4.84763849
5DNA strand elongation (GO:0022616)4.81131836
6neutrophil activation involved in immune response (GO:0002283)4.74291026
7regulation of B cell receptor signaling pathway (GO:0050855)4.68352070
8telomere maintenance via recombination (GO:0000722)4.49720073
9DNA unwinding involved in DNA replication (GO:0006268)4.36967688
10DNA replication initiation (GO:0006270)4.34737832
11mitotic recombination (GO:0006312)4.08498621
12viral transcription (GO:0019083)4.00513856
13positive regulation of mast cell activation (GO:0033005)3.98566222
14nucleotide-excision repair, DNA gap filling (GO:0006297)3.96768739
15deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.94874251
16translational termination (GO:0006415)3.94545927
17maturation of SSU-rRNA (GO:0030490)3.80283962
18telomere maintenance via telomere lengthening (GO:0010833)3.75549294
19CENP-A containing nucleosome assembly (GO:0034080)3.73018920
20ribosomal small subunit biogenesis (GO:0042274)3.70681991
21chromatin remodeling at centromere (GO:0031055)3.68157884
22translational elongation (GO:0006414)3.63828414
23neutrophil activation (GO:0042119)3.63627023
24formation of translation preinitiation complex (GO:0001731)3.58021816
25positive regulation of mast cell degranulation (GO:0043306)3.56161346
26positive regulation of mast cell activation involved in immune response (GO:0033008)3.56161346
27SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.52074022
28positive regulation of gamma-delta T cell activation (GO:0046645)3.48064394
29cotranslational protein targeting to membrane (GO:0006613)3.47735924
30positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.46151696
31protein targeting to ER (GO:0045047)3.43649664
32negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.40988709
33negative regulation of cell killing (GO:0031342)3.40988709
34DNA replication-independent nucleosome assembly (GO:0006336)3.40546738
35DNA replication-independent nucleosome organization (GO:0034724)3.40546738
36establishment of integrated proviral latency (GO:0075713)3.37271703
37respiratory burst (GO:0045730)3.29581176
38protein K11-linked deubiquitination (GO:0035871)3.27896768
39translational initiation (GO:0006413)3.27519338
40protein localization to endoplasmic reticulum (GO:0070972)3.27019177
41establishment of protein localization to endoplasmic reticulum (GO:0072599)3.26915947
42negative regulation of DNA recombination (GO:0045910)3.25802941
43nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.19493068
44meiotic chromosome segregation (GO:0045132)3.19268654
45viral life cycle (GO:0019058)3.15450048
46cellular protein complex disassembly (GO:0043624)3.13737785
47granulocyte activation (GO:0036230)3.11414070
48pseudouridine synthesis (GO:0001522)3.10579387
49regulation of T cell tolerance induction (GO:0002664)3.08953153
50hepatocyte apoptotic process (GO:0097284)3.08704765
51regulation of T cell cytokine production (GO:0002724)3.08119663
52kinetochore organization (GO:0051383)3.07232452
53attachment of spindle microtubules to kinetochore (GO:0008608)3.05156573
54translesion synthesis (GO:0019985)3.04267975
55DNA replication-dependent nucleosome assembly (GO:0006335)3.03789565
56DNA replication-dependent nucleosome organization (GO:0034723)3.03789565
57imidazole-containing compound metabolic process (GO:0052803)3.01598172
58ribosomal large subunit biogenesis (GO:0042273)3.01201132
59positive regulation by symbiont of host defense response (GO:0052509)2.98828753
60modulation by symbiont of host defense response (GO:0052031)2.98828753
61modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.98828753
62modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.98828753
63positive regulation by organism of defense response of other organism involved in symbiotic interact2.98828753
64modulation by symbiont of host immune response (GO:0052553)2.98828753
65telomere organization (GO:0032200)2.97669925
66histone exchange (GO:0043486)2.96461585
67mitotic chromosome condensation (GO:0007076)2.96433222
68exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.96057006
69proteasome assembly (GO:0043248)2.95742751
70telomere maintenance (GO:0000723)2.95612765
71B cell mediated immunity (GO:0019724)2.92669021
72protein localization to kinetochore (GO:0034501)2.92637895
73protein localization to chromosome, centromeric region (GO:0071459)2.92527520
74regulation of mast cell activation involved in immune response (GO:0033006)2.91471734
75ribonucleoprotein complex biogenesis (GO:0022613)2.90092621
76immunoglobulin mediated immune response (GO:0016064)2.90042456
77protein neddylation (GO:0045116)2.89612726
78detection of molecule of bacterial origin (GO:0032490)2.87526177
79nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.87169433
80L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.85189533
81neutrophil mediated immunity (GO:0002446)2.84715857
82protein complex disassembly (GO:0043241)2.83834309
83regulation of mast cell activation (GO:0033003)2.83785417
84regulation of interferon-beta biosynthetic process (GO:0045357)2.82579351
85negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.81762570
86DNA replication checkpoint (GO:0000076)2.80873187
87somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.80299614
88isotype switching (GO:0045190)2.80299614
89somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.80299614
90rRNA processing (GO:0006364)2.79521244
91iron-sulfur cluster assembly (GO:0016226)2.78952183
92metallo-sulfur cluster assembly (GO:0031163)2.78952183
93transcription-coupled nucleotide-excision repair (GO:0006283)2.77757622
94mitotic nuclear envelope disassembly (GO:0007077)2.75453079
95detection of other organism (GO:0098543)2.75202731
96activated T cell proliferation (GO:0050798)2.73655701
97regulation of regulatory T cell differentiation (GO:0045589)2.73066704
98negative regulation of B cell proliferation (GO:0030889)2.70711445
99regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.69385405
100nucleobase biosynthetic process (GO:0046112)2.69121220
101response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.69103521
102response to host immune response (GO:0052572)2.69103521
103IMP metabolic process (GO:0046040)2.68858038
104regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.68809929
105nuclear-transcribed mRNA catabolic process (GO:0000956)2.67903778
106interferon-gamma production (GO:0032609)2.67617556
107rRNA metabolic process (GO:0016072)2.67541358
108anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.67524899
109macromolecular complex disassembly (GO:0032984)2.67428016
110regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.66924168
111establishment of viral latency (GO:0019043)2.66208744
112cell cycle G1/S phase transition (GO:0044843)2.66188651
113G1/S transition of mitotic cell cycle (GO:0000082)2.66188651
114negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.65437410
115negative regulation of ligase activity (GO:0051352)2.65437410
116negative regulation of interleukin-12 production (GO:0032695)2.64978019
117response to peptidoglycan (GO:0032494)2.64641865
118regulation of tolerance induction (GO:0002643)2.64450098
119positive regulation of granulocyte differentiation (GO:0030854)2.64029397
120membrane disassembly (GO:0030397)2.63154833
121nuclear envelope disassembly (GO:0051081)2.63154833
122regulation of MHC class II biosynthetic process (GO:0045346)2.62465760
123positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.62361368
124cellular biogenic amine biosynthetic process (GO:0042401)2.60581315
125positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.60310763
126Arp2/3 complex-mediated actin nucleation (GO:0034314)2.59886653
127intra-S DNA damage checkpoint (GO:0031573)2.59664934
128mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.59341889
129positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.59341889
130regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.58796950
131microglial cell activation (GO:0001774)2.58792407
132regulation of helicase activity (GO:0051095)2.58710880
133chromatin assembly or disassembly (GO:0006333)2.58655321
134leukocyte migration involved in inflammatory response (GO:0002523)2.58428048
135translation (GO:0006412)2.58423145
136antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.58400854
137IMP biosynthetic process (GO:0006188)2.57855917
138positive regulation of interferon-alpha production (GO:0032727)2.57399584
139kinetochore assembly (GO:0051382)2.57051493
140superoxide anion generation (GO:0042554)2.56894046
141positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.56735105
142mRNA catabolic process (GO:0006402)2.56681073
143sequestering of actin monomers (GO:0042989)2.56207382
144ribosome biogenesis (GO:0042254)2.56020821
145macrophage activation involved in immune response (GO:0002281)2.55825272
146antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.55299973
147positive regulation of leukocyte degranulation (GO:0043302)2.55192270
148mismatch repair (GO:0006298)2.55069766
149regulation of mast cell degranulation (GO:0043304)2.54448612
150positive regulation of alpha-beta T cell proliferation (GO:0046641)2.53498868
151pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.52855610
152purine-containing compound salvage (GO:0043101)2.52793753
153detection of external biotic stimulus (GO:0098581)2.52315816
154regulation of interferon-alpha production (GO:0032647)2.51567953
155detection of bacterium (GO:0016045)2.51019096
156DNA ligation (GO:0006266)2.50744014
157RNA catabolic process (GO:0006401)2.50663196
158ribosome assembly (GO:0042255)2.49806679
159negative regulation of lymphocyte mediated immunity (GO:0002707)2.47961605
160maturation of 5.8S rRNA (GO:0000460)2.47171996
161amine biosynthetic process (GO:0009309)2.46268466
162DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.46261277
163definitive hemopoiesis (GO:0060216)2.46220536
164somatic hypermutation of immunoglobulin genes (GO:0016446)2.45278325
165somatic diversification of immune receptors via somatic mutation (GO:0002566)2.45278325
166mitotic metaphase plate congression (GO:0007080)2.44822415
167DNA duplex unwinding (GO:0032508)2.44401241
168antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.44371440
169deoxyribonucleotide biosynthetic process (GO:0009263)2.43934873
170histone mRNA catabolic process (GO:0071044)2.43482969
171mucosal immune response (GO:0002385)2.42775120
172leukocyte aggregation (GO:0070486)2.42665994
173myeloid cell activation involved in immune response (GO:0002275)2.41863768
174regulation of alpha-beta T cell proliferation (GO:0046640)2.40534020
175positive regulation of B cell differentiation (GO:0045579)2.39727397
176regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.39655938
177pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.38747643
178organ or tissue specific immune response (GO:0002251)2.38341728
179regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.37148972
180antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.36987211
181purine nucleobase biosynthetic process (GO:0009113)2.36803163
182regulation of Golgi to plasma membrane protein transport (GO:0042996)2.34706236
183branched-chain amino acid catabolic process (GO:0009083)2.32401509
184neural tube formation (GO:0001841)2.31944031
185negative regulation of cAMP-mediated signaling (GO:0043951)2.29901115
186B cell receptor signaling pathway (GO:0050853)2.29801236
187myeloid leukocyte mediated immunity (GO:0002444)2.28861112
188T cell proliferation (GO:0042098)2.28146128
189preassembly of GPI anchor in ER membrane (GO:0016254)2.27372285
190regulation of Cdc42 GTPase activity (GO:0043088)2.26079909
191G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.25673462
192regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.25440250
193positive regulation of hair follicle development (GO:0051798)2.23641893
194positive regulation of hair cycle (GO:0042635)2.23641893
195detection of biotic stimulus (GO:0009595)2.20562267
196positive regulation of regulated secretory pathway (GO:1903307)2.18356466
197platelet dense granule organization (GO:0060155)2.18216678
198polyamine biosynthetic process (GO:0006596)2.17802251

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.02806339
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.53669156
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.01694907
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.94866292
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.23276520
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.17952544
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.17506506
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.87668075
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.78605041
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.72661366
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.63752948
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.62732932
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.57166178
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.49131025
15SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.47912292
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.47300968
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.41893346
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.39604726
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.39468505
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.34100422
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.28328633
22TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.27295382
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.27123394
24XRN2_22483619_ChIP-Seq_HELA_Human2.25331054
25* VDR_23849224_ChIP-Seq_CD4+_Human2.20934748
26IRF1_19129219_ChIP-ChIP_H3396_Human2.19674254
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.17476216
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.11530964
29NELFA_20434984_ChIP-Seq_ESCs_Mouse2.09670177
30DCP1A_22483619_ChIP-Seq_HELA_Human1.93803260
31AR_21909140_ChIP-Seq_LNCAP_Human1.91954163
32* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.91841816
33E2F1_18555785_ChIP-Seq_MESCs_Mouse1.89923127
34FOXP3_21729870_ChIP-Seq_TREG_Human1.89401526
35SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.89058339
36CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.88438680
37FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.87876932
38MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.87540065
39E2F1_21310950_ChIP-Seq_MCF-7_Human1.85001869
40ERG_20887958_ChIP-Seq_HPC-7_Mouse1.82664003
41MYC_22102868_ChIP-Seq_BL_Human1.81833896
42FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.81823507
43IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.79401457
44STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.79322223
45SCL_19346495_ChIP-Seq_HPC-7_Human1.78346942
46GABP_19822575_ChIP-Seq_HepG2_Human1.75198081
47SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.75099015
48IRF8_27001747_Chip-Seq_BMDM_Mouse1.71362004
49HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.71182645
50SPI1_23547873_ChIP-Seq_NB4_Human1.69555159
51ZFX_18555785_ChIP-Seq_MESCs_Mouse1.69269076
52PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68591367
53SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.64956695
54TTF2_22483619_ChIP-Seq_HELA_Human1.64663894
55MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.63377502
56ELK1_19687146_ChIP-ChIP_HELA_Human1.59004069
57SRF_21415370_ChIP-Seq_HL-1_Mouse1.56863279
58THAP11_20581084_ChIP-Seq_MESCs_Mouse1.56437483
59IRF8_22096565_ChIP-ChIP_GC-B_Human1.55670940
60TAF15_26573619_Chip-Seq_HEK293_Human1.54640871
61EGR1_19374776_ChIP-ChIP_THP-1_Human1.53074767
62MYCN_18555785_ChIP-Seq_MESCs_Mouse1.52670165
63MYB_21317192_ChIP-Seq_ERMYB_Mouse1.52140713
64STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.51647527
65VDR_21846776_ChIP-Seq_THP-1_Human1.51286181
66IRF8_21731497_ChIP-ChIP_J774_Mouse1.50163715
67NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.49720004
68ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.48855030
69FLI1_27457419_Chip-Seq_LIVER_Mouse1.47827693
70RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.47304361
71CIITA_25753668_ChIP-Seq_RAJI_Human1.46492934
72STAT4_19710469_ChIP-ChIP_TH1__Mouse1.39124516
73GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.35657930
74E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.33505173
75NOTCH1_21737748_ChIP-Seq_TLL_Human1.32799522
76MYB_26560356_Chip-Seq_TH2_Human1.26424608
77GATA3_27048872_Chip-Seq_THYMUS_Human1.26325921
78POU3F2_20337985_ChIP-ChIP_501MEL_Human1.25346855
79GATA1_22025678_ChIP-Seq_K562_Human1.23823374
80MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.22161247
81CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21879269
82PADI4_21655091_ChIP-ChIP_MCF-7_Human1.21765119
83STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.21455028
84GATA3_26560356_Chip-Seq_TH2_Human1.19407776
85TFEB_21752829_ChIP-Seq_HELA_Human1.18640768
86Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.18570492
87LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.18068107
88POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.16834875
89EGR1_23403033_ChIP-Seq_LIVER_Mouse1.14564021
90NANOG_18555785_ChIP-Seq_MESCs_Mouse1.14551616
91CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.13762615
92CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.12131898
93RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.12071515
94GATA1_22383799_ChIP-Seq_G1ME_Mouse1.11962617
95RUNX1_22412390_ChIP-Seq_EML_Mouse1.10270617
96YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08803462
97* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.08720357
98ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.07898234
99* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.07658245
100PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.06727492
101KDM5A_27292631_Chip-Seq_BREAST_Human1.06245604
102IGF1R_20145208_ChIP-Seq_DFB_Human1.04612837
103TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.03062926
104MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.02923933
105VDR_24763502_ChIP-Seq_THP-1_Human1.02110029
106MYB_26560356_Chip-Seq_TH1_Human1.01232254
107PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.01107277
108MAF_26560356_Chip-Seq_TH1_Human1.01010059
109HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.00512370
110FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.99847302
111SMAD_19615063_ChIP-ChIP_OVARY_Human0.99808361
112YY1_21170310_ChIP-Seq_MESCs_Mouse0.99362317
113MYC_18940864_ChIP-ChIP_HL60_Human0.98655605
114EWS_26573619_Chip-Seq_HEK293_Human0.97713716
115TP53_22573176_ChIP-Seq_HFKS_Human0.97507100
116CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.96739409
117SPI1_23127762_ChIP-Seq_K562_Human0.96510732
118IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.95586040
119GATA2_22383799_ChIP-Seq_G1ME_Mouse0.95476458
120UTX_26944678_Chip-Seq_JUKART_Human0.94982393
121E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.93662729
122CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.93326166
123FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92668341
124ETS1_22383799_ChIP-Seq_G1ME_Mouse0.87450563
125DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.86365051
126LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.85237314
127RBPJ_22232070_ChIP-Seq_NCS_Mouse0.84919036
128KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.84727782
129ELK1_22589737_ChIP-Seq_MCF10A_Human0.84211218
130* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.82442167

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.71087508
2MP0004957_abnormal_blastocyst_morpholog3.38950617
3MP0002396_abnormal_hematopoietic_system3.26179952
4MP0003693_abnormal_embryo_hatching3.21398652
5MP0003077_abnormal_cell_cycle3.05012285
6MP0008057_abnormal_DNA_replication2.76903627
7MP0003111_abnormal_nucleus_morphology2.69692456
8MP0003183_abnormal_peptide_metabolism2.64207088
9MP0008058_abnormal_DNA_repair2.56475831
10MP0003787_abnormal_imprinting2.49584242
11MP0008260_abnormal_autophagy2.49184498
12MP0008007_abnormal_cellular_replicative2.46266250
13MP0004808_abnormal_hematopoietic_stem2.45954235
14MP0001835_abnormal_antigen_presentation2.42931429
15MP0000490_abnormal_crypts_of2.35756439
16MP0008877_abnormal_DNA_methylation2.14948924
17MP0002254_reproductive_system_inflammat2.05488959
18MP0000685_abnormal_immune_system2.01352544
19MP0004147_increased_porphyrin_level1.96877162
20MP0005310_abnormal_salivary_gland1.96796697
21MP0008932_abnormal_embryonic_tissue1.96322741
22MP0009333_abnormal_splenocyte_physiolog1.95623367
23MP0003123_paternal_imprinting1.93630432
24MP0002398_abnormal_bone_marrow1.93450906
25MP0005671_abnormal_response_to1.93289506
26MP0006054_spinal_hemorrhage1.91884121
27MP0003763_abnormal_thymus_physiology1.87962971
28MP0005397_hematopoietic_system_phenotyp1.80834781
29MP0001545_abnormal_hematopoietic_system1.80834781
30MP0008004_abnormal_stomach_pH1.72286469
31MP0003221_abnormal_cardiomyocyte_apopto1.68623619
32MP0003806_abnormal_nucleotide_metabolis1.65950227
33MP0009785_altered_susceptibility_to1.64635971
34MP0002166_altered_tumor_susceptibility1.64245594
35MP0002006_tumorigenesis1.63661152
36MP0000465_gastrointestinal_hemorrhage1.63633918
37MP0000689_abnormal_spleen_morphology1.59477289
38MP0002722_abnormal_immune_system1.57820510
39MP0006035_abnormal_mitochondrial_morpho1.56810930
40MP0001800_abnormal_humoral_immune1.56337659
41MP0003303_peritoneal_inflammation1.56272000
42MP0002420_abnormal_adaptive_immunity1.56193059
43MP0002452_abnormal_antigen_presenting1.55816640
44MP0001819_abnormal_immune_cell1.54151573
45MP0000350_abnormal_cell_proliferation1.53523388
46MP0000716_abnormal_immune_system1.50785209
47MP0002132_abnormal_respiratory_system1.50615605
48MP0002429_abnormal_blood_cell1.49939596
49MP0005000_abnormal_immune_tolerance1.49768806
50MP0000569_abnormal_digit_pigmentation1.49499522
51MP0010307_abnormal_tumor_latency1.47790831
52MP0002723_abnormal_immune_serum1.47754910
53MP0002019_abnormal_tumor_incidence1.45234986
54MP0002277_abnormal_respiratory_mucosa1.44216588
55MP0000703_abnormal_thymus_morphology1.43860946
56MP0002163_abnormal_gland_morphology1.43617226
57MP0009379_abnormal_foot_pigmentation1.40645065
58MP0005025_abnormal_response_to1.38278121
59MP0001348_abnormal_lacrimal_gland1.37938682
60MP0003786_premature_aging1.37567483
61MP0002148_abnormal_hypersensitivity_rea1.33347270
62MP0000313_abnormal_cell_death1.33049541
63MP0000372_irregular_coat_pigmentation1.32168430
64MP0001730_embryonic_growth_arrest1.31872404
65MP0005174_abnormal_tail_pigmentation1.29891623
66MP0005058_abnormal_lysosome_morphology1.27543492
67MP0010352_gastrointestinal_tract_polyps1.27235002
68MP0005645_abnormal_hypothalamus_physiol1.26251192
69MP0005379_endocrine/exocrine_gland_phen1.25669884
70MP0003436_decreased_susceptibility_to1.23327420
71MP0002210_abnormal_sex_determination1.20718045
72MP0000371_diluted_coat_color1.20654863
73MP0009764_decreased_sensitivity_to1.20030966
74MP0002405_respiratory_system_inflammati1.18919597
75MP0003724_increased_susceptibility_to1.18904301
76MP0002095_abnormal_skin_pigmentation1.17156934
77MP0005075_abnormal_melanosome_morpholog1.12904815
78MP0001697_abnormal_embryo_size1.12624808
79MP0003567_abnormal_fetal_cardiomyocyte1.10992304
80MP0003121_genomic_imprinting1.10918948
81MP0001929_abnormal_gametogenesis1.10830273
82MP0001853_heart_inflammation1.09907407
83MP0005464_abnormal_platelet_physiology1.09375537
84MP0001145_abnormal_male_reproductive1.09242595
85MP0002009_preneoplasia1.08774357
86MP0002419_abnormal_innate_immunity1.07563455
87MP0002080_prenatal_lethality1.05908773
88MP0001873_stomach_inflammation1.03927336
89MP0010155_abnormal_intestine_physiology1.03353548
90MP0002837_dystrophic_cardiac_calcinosis1.01314784
91MP0003656_abnormal_erythrocyte_physiolo1.00890936
92MP0009765_abnormal_xenobiotic_induced0.99333740
93MP0008469_abnormal_protein_level0.99110947
94MP0003122_maternal_imprinting0.98455067
95MP0005387_immune_system_phenotype0.95150372
96MP0001790_abnormal_immune_system0.95150372
97MP0001984_abnormal_olfaction0.93930618
98MP0003186_abnormal_redox_activity0.92941366
99MP0001851_eye_inflammation0.90751119
100MP0000653_abnormal_sex_gland0.90176807
101MP0004510_myositis0.90039404
102MP0006036_abnormal_mitochondrial_physio0.88470073
103MP0001919_abnormal_reproductive_system0.88093029
104MP0008995_early_reproductive_senescence0.87026608
105MP0003300_gastrointestinal_ulcer0.85535052
106MP0009763_increased_sensitivity_to0.85507099
107MP0003866_abnormal_defecation0.85266146
108MP0000858_altered_metastatic_potential0.84988725
109MP0010234_abnormal_vibrissa_follicle0.84430366
110MP0001529_abnormal_vocalization0.83645425
111MP0001764_abnormal_homeostasis0.83196498
112MP0003943_abnormal_hepatobiliary_system0.82970883
113MP0005647_abnormal_sex_gland0.78809957
114MP0003315_abnormal_perineum_morphology0.77269801
115MP0005410_abnormal_fertilization0.77225757
116MP0006082_CNS_inflammation0.74644294
117MP0002933_joint_inflammation0.74590679
118MP0001293_anophthalmia0.73651372
119MP0002085_abnormal_embryonic_tissue0.73107400
120MP0001533_abnormal_skeleton_physiology0.73025451
121MP0001845_abnormal_inflammatory_respons0.71237960
122MP0001958_emphysema0.71066212
123MP0002075_abnormal_coat/hair_pigmentati0.70661871
124MP0000015_abnormal_ear_pigmentation0.70496489
125MP0008961_abnormal_basal_metabolism0.68725748
126MP0005248_abnormal_Harderian_gland0.67999077
127MP0000343_altered_response_to0.67857164
128MP0000358_abnormal_cell_content/0.67838129
129MP0003448_altered_tumor_morphology0.67750746
130MP0004381_abnormal_hair_follicle0.65974362
131MP0005083_abnormal_biliary_tract0.65232523
132MP0005394_taste/olfaction_phenotype0.65215294
133MP0005499_abnormal_olfactory_system0.65215294
134MP0002160_abnormal_reproductive_system0.65119547
135MP0003984_embryonic_growth_retardation0.65114785
136MP0010030_abnormal_orbit_morphology0.64965803
137MP0005380_embryogenesis_phenotype0.64928261
138MP0001672_abnormal_embryogenesis/_devel0.64928261
139MP0002086_abnormal_extraembryonic_tissu0.64373843
140MP0005023_abnormal_wound_healing0.63958112
141MP0001119_abnormal_female_reproductive0.63902215
142MP0001186_pigmentation_phenotype0.62141891

Predicted human phenotypes

RankGene SetZ-score
1Thrombocytosis (HP:0001894)4.32512829
2Abnormality of cells of the erythroid lineage (HP:0012130)4.19322172
3Abnormal number of erythroid precursors (HP:0012131)4.18335041
4IgM deficiency (HP:0002850)4.17205858
5Reticulocytopenia (HP:0001896)4.15338887
6Abnormality of the heme biosynthetic pathway (HP:0010472)4.03643793
7Aplastic anemia (HP:0001915)3.88831461
8Decreased activity of mitochondrial respiratory chain (HP:0008972)3.37960404
9Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.37960404
10Optic neuritis (HP:0100653)3.36268234
11Retrobulbar optic neuritis (HP:0100654)3.36268234
12Stomatitis (HP:0010280)3.36053829
13Abnormality of macrophages (HP:0004311)3.34375822
14Orchitis (HP:0100796)3.28372884
15Colon cancer (HP:0003003)3.26177512
16Aplasia/Hypoplasia of the sacrum (HP:0008517)3.08164591
17Elevated erythrocyte sedimentation rate (HP:0003565)2.99790837
18Chronic otitis media (HP:0000389)2.97590187
19Type I transferrin isoform profile (HP:0003642)2.93780832
20Pallor (HP:0000980)2.91590253
21Amaurosis fugax (HP:0100576)2.90279968
22Petechiae (HP:0000967)2.87958801
23Gingival bleeding (HP:0000225)2.86653929
24Selective tooth agenesis (HP:0001592)2.85776795
25Eczematoid dermatitis (HP:0000976)2.80103670
263-Methylglutaconic aciduria (HP:0003535)2.77369171
27Loss of speech (HP:0002371)2.76793102
28Myelodysplasia (HP:0002863)2.70448290
29Cerebral hypomyelination (HP:0006808)2.69634321
30B lymphocytopenia (HP:0010976)2.64830356
31Abnormality of B cell number (HP:0010975)2.64830356
32Myositis (HP:0100614)2.61659512
33Birth length less than 3rd percentile (HP:0003561)2.58292868
34Encephalitis (HP:0002383)2.55431063
3511 pairs of ribs (HP:0000878)2.54880939
36Oral leukoplakia (HP:0002745)2.54657877
37Pancytopenia (HP:0001876)2.45640976
38Abnormality of chromosome stability (HP:0003220)2.44460709
39Abnormal protein glycosylation (HP:0012346)2.42677140
40Abnormal glycosylation (HP:0012345)2.42677140
41Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.42677140
42Abnormal protein N-linked glycosylation (HP:0012347)2.42677140
43Recurrent bronchitis (HP:0002837)2.41419984
44Anorexia (HP:0002039)2.40064434
45Macrocytic anemia (HP:0001972)2.38794068
46T lymphocytopenia (HP:0005403)2.37829939
47Microretrognathia (HP:0000308)2.37240055
48Recurrent abscess formation (HP:0002722)2.35700636
49Vasculitis (HP:0002633)2.32927213
50Lymphoma (HP:0002665)2.31688772
51Agnosia (HP:0010524)2.30901793
52Poor head control (HP:0002421)2.28292497
53Mediastinal lymphadenopathy (HP:0100721)2.26951572
54Recurrent cutaneous fungal infections (HP:0011370)2.26826338
55Chronic mucocutaneous candidiasis (HP:0002728)2.26826338
56Abnormal platelet volume (HP:0011876)2.26653634
57Reduced antithrombin III activity (HP:0001976)2.25465960
58Ragged-red muscle fibers (HP:0003200)2.23944452
59Abnormality of the anterior horn cell (HP:0006802)2.23738194
60Degeneration of anterior horn cells (HP:0002398)2.23738194
61Basal cell carcinoma (HP:0002671)2.23500500
62Spontaneous hematomas (HP:0007420)2.22786641
63Abnormality of alanine metabolism (HP:0010916)2.22548060
64Hyperalaninemia (HP:0003348)2.22548060
65Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.22548060
66Premature graying of hair (HP:0002216)2.20906594
67Keratoconjunctivitis (HP:0001096)2.20311268
68Abnormal lung lobation (HP:0002101)2.20208242
69Acute hepatic failure (HP:0006554)2.19312658
70Epistaxis (HP:0000421)2.18280640
71Vacuolated lymphocytes (HP:0001922)2.14953852
72Papillary thyroid carcinoma (HP:0002895)2.14010220
73Recurrent fungal infections (HP:0002841)2.11083948
74Abnormality of T cell number (HP:0011839)2.09404630
75Recurrent sinusitis (HP:0011108)2.08489639
76Recurrent skin infections (HP:0001581)2.08131515
77Recurrent viral infections (HP:0004429)2.08106076
78Abnormal spermatogenesis (HP:0008669)2.07847112
79Cellulitis (HP:0100658)2.07162331
80Muscle fiber atrophy (HP:0100295)2.06387464
81Abnormality of glycolysis (HP:0004366)2.05416439
82Increased serum pyruvate (HP:0003542)2.05416439
83Medulloblastoma (HP:0002885)2.03918965
84Cholecystitis (HP:0001082)2.03243296
85Abnormal gallbladder physiology (HP:0012438)2.03243296
86Renal Fanconi syndrome (HP:0001994)2.02866357
87Hyperglycinemia (HP:0002154)2.02588218
88Bone marrow hypocellularity (HP:0005528)2.02151387
89Urticaria (HP:0001025)2.00940921
90Keratoconjunctivitis sicca (HP:0001097)2.00333231
91IgG deficiency (HP:0004315)2.00217777
92Purpura (HP:0000979)1.99520777
93Arterial thrombosis (HP:0004420)1.98492342
94Increased mean platelet volume (HP:0011877)1.97655603
95Carpal bone hypoplasia (HP:0001498)1.95980622
96Recurrent bacterial skin infections (HP:0005406)1.95399015
97Duodenal stenosis (HP:0100867)1.95134218
98Small intestinal stenosis (HP:0012848)1.95134218
99Exertional dyspnea (HP:0002875)1.94809632
100Chromsome breakage (HP:0040012)1.94007401
101Postnatal microcephaly (HP:0005484)1.93121718
102Pulmonary fibrosis (HP:0002206)1.92033691
103Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.91894687
104Nephrogenic diabetes insipidus (HP:0009806)1.90147022
105Increased intramyocellular lipid droplets (HP:0012240)1.88963109
106Abnormal pancreas size (HP:0012094)1.88677258
107Obstructive lung disease (HP:0006536)1.88596867
108Chronic obstructive pulmonary disease (HP:0006510)1.88596867
109Increased density of long bones (HP:0006392)1.87975215
110Acute myeloid leukemia (HP:0004808)1.86993493
111Meningitis (HP:0001287)1.86964991
112Abnormality of T cells (HP:0002843)1.86227168
113CNS hypomyelination (HP:0003429)1.86010680
114Abnormality of the preputium (HP:0100587)1.85908611
115Increased IgM level (HP:0003496)1.85307405
116Type 2 muscle fiber atrophy (HP:0003554)1.84562810
117Lymphopenia (HP:0001888)1.84423337
118Rough bone trabeculation (HP:0100670)1.84345607
119Neoplasm of the pancreas (HP:0002894)1.84147062
120Neoplasm of the adrenal cortex (HP:0100641)1.83639839
121Gangrene (HP:0100758)1.82570686
122Hepatocellular necrosis (HP:0001404)1.82172127
123Abnormality of cells of the lymphoid lineage (HP:0012140)1.82130759
124Autoimmune hemolytic anemia (HP:0001890)1.82128992
125Asplenia (HP:0001746)1.81707024
126Recurrent gram-negative bacterial infections (HP:0005420)1.81610569
127Prolonged bleeding time (HP:0003010)1.79567590
128Progressive neurologic deterioration (HP:0002344)1.78741443
129Breast hypoplasia (HP:0003187)1.78310052
130Absent thumb (HP:0009777)1.78153753
131Increased hepatocellular lipid droplets (HP:0006565)1.77303418
132Abnormal delayed hypersensitivity skin test (HP:0002963)1.76528056
133Limb hypertonia (HP:0002509)1.75942337
134Abnormality of the pons (HP:0007361)1.75304460
135Thyroid carcinoma (HP:0002890)1.74936259
136Episodic fever (HP:0001954)1.74073811
137Neoplasm of the adrenal gland (HP:0100631)1.74061740
138Menorrhagia (HP:0000132)1.73265365
139Fatigue (HP:0012378)1.72839846
140Breast carcinoma (HP:0003002)1.72036195
141Rhabdomyosarcoma (HP:0002859)1.71859673
142Increased serum lactate (HP:0002151)1.70912050
143Abnormality of T cell physiology (HP:0011840)1.70319933
144Panhypogammaglobulinemia (HP:0003139)1.69568149
145Abnormality of glycine metabolism (HP:0010895)1.68965587
146Abnormality of serine family amino acid metabolism (HP:0010894)1.68965587
147Aplasia/Hypoplasia of the uvula (HP:0010293)1.66257307
148Chest pain (HP:0100749)1.66221503
149Hyperglycinuria (HP:0003108)1.65363920
150Short middle phalanx of the 5th finger (HP:0004220)1.65100425
151Hepatosplenomegaly (HP:0001433)1.64915041
152Neoplasm of the oral cavity (HP:0100649)1.64769511
153Abnormality of the columella (HP:0009929)1.64380719
154Meckel diverticulum (HP:0002245)1.63997955
155Orthostatic hypotension (HP:0001278)1.63752450
156Chromosomal breakage induced by crosslinking agents (HP:0003221)1.62961343
157Respiratory difficulties (HP:0002880)1.62298109
158Mitochondrial inheritance (HP:0001427)1.61363975
159Abnormality of glycolipid metabolism (HP:0010969)1.60926352
160Abnormality of liposaccharide metabolism (HP:0010968)1.60926352
161Abnormality of glycosphingolipid metabolism (HP:0004343)1.60926352
162Broad palm (HP:0001169)1.60505578
163Abnormality of the ileum (HP:0001549)1.60199543
164Vertebral compression fractures (HP:0002953)1.60162615
165Gastrointestinal infarctions (HP:0005244)1.59651577
166Capillary hemangiomas (HP:0005306)1.59609358
167Leukocytosis (HP:0001974)1.59137269
168Abnormality of the vasculature of the conjunctiva (HP:0008054)1.59050726
169Cleft eyelid (HP:0000625)1.58465053
170Abnormality of the prostate (HP:0008775)1.58363744
171Pulmonary embolism (HP:0002204)1.57920280
172Abnormal trabecular bone morphology (HP:0100671)1.57740160
173IgA deficiency (HP:0002720)1.57713451
174Inflammation of the large intestine (HP:0002037)1.57322822
175Nephroblastoma (Wilms tumor) (HP:0002667)1.57293105
176Abnormality of serum amino acid levels (HP:0003112)1.56973851
177Neutropenia (HP:0001875)1.55749637
178Congenital primary aphakia (HP:0007707)1.55055698
179Polyneuropathy (HP:0001271)1.53181989
180Hypoplasia of the uterus (HP:0000013)1.52868810

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM283.84490430
2EIF2AK13.51593531
3WEE13.34981301
4BUB13.29427610
5CDC73.09355837
6EIF2AK33.07563356
7ACVR1B2.81011412
8TESK22.57134263
9FRK2.45438747
10ZAK2.44689010
11RIPK42.24627044
12FGR2.16927966
13NEK22.13528149
14BRSK22.13277412
15WNK32.06575886
16SCYL21.99553076
17PASK1.98970398
18VRK11.93874006
19MAP4K11.90878499
20MAP4K21.87799239
21NME21.87114092
22BMPR21.86436454
23PBK1.85431181
24STK161.81283102
25GRK61.79884755
26TGFBR11.76491748
27MKNK11.73552377
28SIK31.64143501
29YES11.58309596
30FLT31.55592700
31CDK191.53606144
32TESK11.50768836
33TTK1.49885399
34IRAK11.49450795
35TEC1.43831219
36TAF11.43813760
37FES1.39344526
38MAPKAPK51.34772830
39NEK11.34439860
40TNIK1.33888461
41JAK31.33772068
42BRSK11.32448249
43ATR1.30759712
44BTK1.30127890
45CSK1.30068524
46BLK1.29656813
47STK101.28562815
48KIT1.26638112
49BCR1.26258161
50PIM21.25664168
51CLK11.25601522
52RPS6KB21.25086719
53DYRK31.24740825
54PLK11.22603864
55EEF2K1.18618820
56AURKB1.18086528
57CSNK1G11.12657742
58CDK71.11712431
59MAP3K81.10192477
60KDR1.10177756
61STK41.09447359
62PAK41.08663730
63CSNK1G21.08489364
64MAPKAPK31.07107868
65SRPK11.06504211
66MUSK1.06338765
67RPS6KA41.06023974
68TSSK61.05118676
69CSNK1A1L1.04690838
70FER1.03360196
71RAF11.03133696
72LRRK21.02924678
73ERBB31.02179698
74LIMK10.99884399
75TLK10.99686212
76MARK30.98914132
77CHEK20.98706410
78TAOK10.98197131
79MAP2K70.97065122
80PKN20.95736982
81ZAP700.92879163
82CDK80.89756837
83CSF1R0.87790549
84TNK20.87088703
85PLK40.86925927
86CCNB10.85592335
87VRK20.85538564
88TYK20.85328834
89CDK40.82157153
90JAK20.81389684
91AURKA0.81219537
92NUAK10.80183456
93PAK10.76108744
94CAMKK20.74425872
95MST40.74299764
96TBK10.73912278
97HCK0.73587823
98MAP3K120.72816740
99BCKDK0.70687059
100IRAK40.70159533
101MAP3K110.69689442
102PIM10.68051780
103CSNK1G30.67937506
104MAP3K50.67584420
105ILK0.66858992
106IRAK20.65992422
107MAP3K40.65904626
108BRD40.65428769
109TAOK30.64865777
110MAP3K140.64412875
111MELK0.63959358
112SYK0.63944721
113BMX0.63038137
114ARAF0.61399531
115MAP2K30.60887245
116EPHB10.60674465
117LCK0.60507576
118PRKG20.60463808
119EIF2AK20.60431947
120CHEK10.57561507
121LYN0.56879440
122DAPK10.53824205
123MKNK20.53043147
124MOS0.52550656
125MATK0.52313896
126DYRK1B0.51754176
127RPS6KA50.51394580
128MYLK0.51224587
129BRAF0.49900211
130IKBKB0.49168352
131PLK30.47866525
132BMPR1B0.46720491
133OXSR10.46289688
134ITK0.45966799
135STK390.45753948
136TXK0.43812200
137ATM0.43336913
138CSNK2A10.41092622
139EGFR0.40429517
140TGFBR20.39468993
141NLK0.39287214
142MAP3K20.39147896
143CSNK2A20.38976967
144IKBKE0.36334152
145STK30.35802875
146JAK10.34624015
147CHUK0.33972801
148MAP3K60.27103309
149CSNK1A10.26414983
150CDK60.26158006
151PTK2B0.26154304
152MAPK110.24908859

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.14820120
2Mismatch repair_Homo sapiens_hsa034304.15180771
3Ribosome_Homo sapiens_hsa030103.39976207
4Homologous recombination_Homo sapiens_hsa034402.97795794
5Base excision repair_Homo sapiens_hsa034102.84203779
6Proteasome_Homo sapiens_hsa030502.79758395
7Nucleotide excision repair_Homo sapiens_hsa034202.61965214
8Spliceosome_Homo sapiens_hsa030402.49708098
9RNA polymerase_Homo sapiens_hsa030202.44089748
10Cell cycle_Homo sapiens_hsa041102.40364939
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.33901560
12Non-homologous end-joining_Homo sapiens_hsa034502.25779507
13Pyrimidine metabolism_Homo sapiens_hsa002402.24551183
14RNA transport_Homo sapiens_hsa030132.05932623
15Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.02689319
16RNA degradation_Homo sapiens_hsa030181.82556018
17Glycosaminoglycan degradation_Homo sapiens_hsa005311.69351497
18Fanconi anemia pathway_Homo sapiens_hsa034601.64928731
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.64404108
20Basal transcription factors_Homo sapiens_hsa030221.62961072
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.59127521
22Regulation of autophagy_Homo sapiens_hsa041401.58764630
23Protein export_Homo sapiens_hsa030601.54893247
24Autoimmune thyroid disease_Homo sapiens_hsa053201.41983801
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.39558172
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.37046418
27Collecting duct acid secretion_Homo sapiens_hsa049661.35608130
28Type I diabetes mellitus_Homo sapiens_hsa049401.28392942
29p53 signaling pathway_Homo sapiens_hsa041151.28075754
30Antigen processing and presentation_Homo sapiens_hsa046121.27177514
31Herpes simplex infection_Homo sapiens_hsa051681.27166986
32Galactose metabolism_Homo sapiens_hsa000521.25945552
33Peroxisome_Homo sapiens_hsa041461.24653955
34Primary immunodeficiency_Homo sapiens_hsa053401.22063507
35Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.21639252
36Fatty acid elongation_Homo sapiens_hsa000621.21251923
37Purine metabolism_Homo sapiens_hsa002301.19046615
38Shigellosis_Homo sapiens_hsa051311.17033633
39Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.13962171
40One carbon pool by folate_Homo sapiens_hsa006701.13721647
41Tuberculosis_Homo sapiens_hsa051521.10930168
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.10809180
43Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.09392201
44Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.06914819
45Epstein-Barr virus infection_Homo sapiens_hsa051691.06722408
46Staphylococcus aureus infection_Homo sapiens_hsa051501.00427499
47Measles_Homo sapiens_hsa051620.99010592
48Rheumatoid arthritis_Homo sapiens_hsa053230.95347263
49Propanoate metabolism_Homo sapiens_hsa006400.94436400
50Viral carcinogenesis_Homo sapiens_hsa052030.91741269
51Leishmaniasis_Homo sapiens_hsa051400.91027647
52Systemic lupus erythematosus_Homo sapiens_hsa053220.90086524
53Thyroid cancer_Homo sapiens_hsa052160.88743314
54Biosynthesis of amino acids_Homo sapiens_hsa012300.87981913
55Lysosome_Homo sapiens_hsa041420.86310133
56N-Glycan biosynthesis_Homo sapiens_hsa005100.85765241
57mRNA surveillance pathway_Homo sapiens_hsa030150.84781641
58Phagosome_Homo sapiens_hsa041450.79559332
59Oocyte meiosis_Homo sapiens_hsa041140.78578885
60Pentose phosphate pathway_Homo sapiens_hsa000300.74112786
61Chemokine signaling pathway_Homo sapiens_hsa040620.73777718
62Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.73507365
63Parkinsons disease_Homo sapiens_hsa050120.73251399
64Legionellosis_Homo sapiens_hsa051340.73071464
65Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.71461266
66Intestinal immune network for IgA production_Homo sapiens_hsa046720.70692395
67Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.69570562
68Hepatitis B_Homo sapiens_hsa051610.68063967
69Asthma_Homo sapiens_hsa053100.67797477
70HTLV-I infection_Homo sapiens_hsa051660.67550355
71Cyanoamino acid metabolism_Homo sapiens_hsa004600.67117618
72Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.66106993
73RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.66092181
74Folate biosynthesis_Homo sapiens_hsa007900.65500215
75NF-kappa B signaling pathway_Homo sapiens_hsa040640.65355585
76B cell receptor signaling pathway_Homo sapiens_hsa046620.64883588
77Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.63753003
78Hematopoietic cell lineage_Homo sapiens_hsa046400.62941151
79Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62327055
80Steroid biosynthesis_Homo sapiens_hsa001000.62291108
81Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.62062645
82Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61948456
83Carbon metabolism_Homo sapiens_hsa012000.61907081
84Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61266378
85Apoptosis_Homo sapiens_hsa042100.61024275
86Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.58595199
87Huntingtons disease_Homo sapiens_hsa050160.57884051
88Allograft rejection_Homo sapiens_hsa053300.57586732
89Influenza A_Homo sapiens_hsa051640.56849755
90Platelet activation_Homo sapiens_hsa046110.56634987
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56467237
92Alcoholism_Homo sapiens_hsa050340.55638471
93Vibrio cholerae infection_Homo sapiens_hsa051100.54768404
94Jak-STAT signaling pathway_Homo sapiens_hsa046300.54149176
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53613565
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53422510
97Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51996864
98Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.50372384
99Malaria_Homo sapiens_hsa051440.49978873
100Glutathione metabolism_Homo sapiens_hsa004800.49934907
101NOD-like receptor signaling pathway_Homo sapiens_hsa046210.49618905
102Small cell lung cancer_Homo sapiens_hsa052220.49268951
103Sphingolipid metabolism_Homo sapiens_hsa006000.49203672
104Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49055224
105Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.48497920
106Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.48340980
107Leukocyte transendothelial migration_Homo sapiens_hsa046700.48011994
108Fatty acid metabolism_Homo sapiens_hsa012120.47445513
109Sulfur relay system_Homo sapiens_hsa041220.47050231
110Alzheimers disease_Homo sapiens_hsa050100.46452810
111Metabolic pathways_Homo sapiens_hsa011000.46192403
112Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.45016209
113Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.43600485
114Salmonella infection_Homo sapiens_hsa051320.43214349
115Oxidative phosphorylation_Homo sapiens_hsa001900.42725485
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42071429
117Chronic myeloid leukemia_Homo sapiens_hsa052200.41314040
118T cell receptor signaling pathway_Homo sapiens_hsa046600.39636581
119Colorectal cancer_Homo sapiens_hsa052100.39545469
120Toxoplasmosis_Homo sapiens_hsa051450.39257029
121Acute myeloid leukemia_Homo sapiens_hsa052210.38811943
122Pancreatic cancer_Homo sapiens_hsa052120.37977286
123Graft-versus-host disease_Homo sapiens_hsa053320.35858836
124Viral myocarditis_Homo sapiens_hsa054160.35527142
125HIF-1 signaling pathway_Homo sapiens_hsa040660.34789414
126Osteoclast differentiation_Homo sapiens_hsa043800.32994282
127MicroRNAs in cancer_Homo sapiens_hsa052060.30591615
128Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.29889889
129Pertussis_Homo sapiens_hsa051330.29620962
130Other glycan degradation_Homo sapiens_hsa005110.29578210
131Cysteine and methionine metabolism_Homo sapiens_hsa002700.28447658
132Toll-like receptor signaling pathway_Homo sapiens_hsa046200.26688756
133Renin-angiotensin system_Homo sapiens_hsa046140.26130273
134Pathways in cancer_Homo sapiens_hsa052000.25223321

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