PDILT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has has an N-terminal ER-signal sequence, two thioredoxin (TRX) domains with non-classical Ser-Lys-Gln-Ser and Ser-Lys-Lys-Cys motifs, respectively, two TRX-like domains, and a C-terminal ER-retention sequence. The protein lacks oxidoreductase activity in vitro and probably functions as a chaperone. This gene's expression appears to be limited to the testis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fusion of sperm to egg plasma membrane (GO:0007342)9.32233270
2sperm motility (GO:0030317)7.94844232
3cell wall macromolecule catabolic process (GO:0016998)7.83960353
4cell wall macromolecule metabolic process (GO:0044036)7.83960353
5multicellular organism reproduction (GO:0032504)7.32570359
6cilium or flagellum-dependent cell motility (GO:0001539)7.06198330
7plasma membrane fusion (GO:0045026)7.02186981
8sperm-egg recognition (GO:0035036)6.88488581
9acrosome assembly (GO:0001675)6.87132094
10acrosome reaction (GO:0007340)6.38862644
11L-phenylalanine catabolic process (GO:0006559)6.22513943
12erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.22513943
13cell-cell recognition (GO:0009988)6.17482240
14reproduction (GO:0000003)6.15907856
15binding of sperm to zona pellucida (GO:0007339)6.04478044
16erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.87038717
17L-phenylalanine metabolic process (GO:0006558)5.87038717
18axonemal dynein complex assembly (GO:0070286)5.71040136
19epithelial cilium movement (GO:0003351)5.70885310
20aromatic amino acid family catabolic process (GO:0009074)5.65809971
21motile cilium assembly (GO:0044458)5.25433302
22tryptophan catabolic process (GO:0006569)5.22504122
23indole-containing compound catabolic process (GO:0042436)5.22504122
24indolalkylamine catabolic process (GO:0046218)5.22504122
25behavioral response to nicotine (GO:0035095)5.10478272
26bile acid biosynthetic process (GO:0006699)5.06376496
27kynurenine metabolic process (GO:0070189)5.05196184
28urea cycle (GO:0000050)5.03180631
29urea metabolic process (GO:0019627)5.03180631
30alpha-linolenic acid metabolic process (GO:0036109)4.95316559
31* spermatid development (GO:0007286)4.91960712
32fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.90768435
33triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.87019903
34tryptophan metabolic process (GO:0006568)4.85335208
35glyoxylate metabolic process (GO:0046487)4.83789817
36complement activation, alternative pathway (GO:0006957)4.80892266
37response to pheromone (GO:0019236)4.71149391
38single fertilization (GO:0007338)4.69802927
39organic cation transport (GO:0015695)4.69744802
40cilium movement (GO:0003341)4.66406875
41regulation of protein activation cascade (GO:2000257)4.62577140
42nitrogen cycle metabolic process (GO:0071941)4.62151577
43epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.53726907
44regulation of cilium movement (GO:0003352)4.51302643
45sulfur amino acid catabolic process (GO:0000098)4.49235519
46regulation of complement activation (GO:0030449)4.37726006
47negative regulation of fibrinolysis (GO:0051918)4.34369986
48cysteine metabolic process (GO:0006534)4.33950462
49negative regulation of telomere maintenance (GO:0032205)4.29343430
50high-density lipoprotein particle remodeling (GO:0034375)4.28449402
51male meiosis (GO:0007140)4.28231898
52sperm capacitation (GO:0048240)4.27379007
53bile acid metabolic process (GO:0008206)4.26584773
54regulation of fibrinolysis (GO:0051917)4.23950730
55piRNA metabolic process (GO:0034587)4.22385637
56regulation of triglyceride catabolic process (GO:0010896)4.15908836
57peptidyl-glutamic acid carboxylation (GO:0017187)4.15693290
58protein carboxylation (GO:0018214)4.15693290
59amino-acid betaine metabolic process (GO:0006577)4.10131818
60protein polyglutamylation (GO:0018095)4.08488333
61serine family amino acid catabolic process (GO:0009071)4.04825086
62aromatic amino acid family metabolic process (GO:0009072)4.01053695
63homocysteine metabolic process (GO:0050667)3.94334745
64ketone body metabolic process (GO:1902224)3.91787201
65coenzyme catabolic process (GO:0009109)3.86961874
66fertilization (GO:0009566)3.85696940
67tyrosine metabolic process (GO:0006570)3.79153064
68lysine metabolic process (GO:0006553)3.79033207
69lysine catabolic process (GO:0006554)3.79033207
70alpha-amino acid catabolic process (GO:1901606)3.76579539
71reverse cholesterol transport (GO:0043691)3.74456272
72synaptonemal complex organization (GO:0070193)3.74175104
73triglyceride homeostasis (GO:0070328)3.70340583
74acylglycerol homeostasis (GO:0055090)3.70340583
75protein-lipid complex remodeling (GO:0034368)3.68915983
76macromolecular complex remodeling (GO:0034367)3.68915983
77plasma lipoprotein particle remodeling (GO:0034369)3.68915983
78bile acid and bile salt transport (GO:0015721)3.64410949
79regulation of cholesterol esterification (GO:0010872)3.64304772
80negative regulation of sterol transport (GO:0032372)3.62023085
81negative regulation of cholesterol transport (GO:0032375)3.62023085
82indolalkylamine metabolic process (GO:0006586)3.61412811
83synaptonemal complex assembly (GO:0007130)3.60936392
84single strand break repair (GO:0000012)3.59992064
85negative regulation of mast cell activation (GO:0033004)3.59192810
86fucose catabolic process (GO:0019317)3.56769125
87L-fucose metabolic process (GO:0042354)3.56769125
88L-fucose catabolic process (GO:0042355)3.56769125
89DNA deamination (GO:0045006)3.54574423
90cytolysis (GO:0019835)3.52756540
91ethanol oxidation (GO:0006069)3.52051408
92positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.51950837
93plasma lipoprotein particle clearance (GO:0034381)3.51810973
94benzene-containing compound metabolic process (GO:0042537)3.51058669
95cellular biogenic amine catabolic process (GO:0042402)3.49815889
96amine catabolic process (GO:0009310)3.49815889
97nephron epithelium morphogenesis (GO:0072088)3.44993414
98nephron tubule morphogenesis (GO:0072078)3.44993414
99cellular amino acid catabolic process (GO:0009063)3.44225144
100cellular glucuronidation (GO:0052695)3.43974758
101imidazole-containing compound metabolic process (GO:0052803)3.40743889
102phospholipid efflux (GO:0033700)3.40559753
103glycine metabolic process (GO:0006544)3.40517619
104aspartate family amino acid catabolic process (GO:0009068)3.40000417
105detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.38313028
106spermatogenesis (GO:0007283)3.38141438
107male gamete generation (GO:0048232)3.36638355
108cofactor catabolic process (GO:0051187)3.35300053
109cellular ketone body metabolic process (GO:0046950)3.33413790
110amino-acid betaine transport (GO:0015838)3.29880773
111carnitine transport (GO:0015879)3.29880773
112complement activation, classical pathway (GO:0006958)3.28949499
113serine family amino acid metabolic process (GO:0009069)3.28629009
114glutamate metabolic process (GO:0006536)3.28582527
115positive regulation of lipoprotein lipase activity (GO:0051006)3.28327821
116regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.18286972
117protein complex biogenesis (GO:0070271)3.11880467
118regulation of activation of Janus kinase activity (GO:0010533)3.05843154
119axoneme assembly (GO:0035082)3.00802675
120kidney morphogenesis (GO:0060993)2.97735781
121mitochondrial respiratory chain complex I assembly (GO:0032981)2.95376946
122NADH dehydrogenase complex assembly (GO:0010257)2.95376946
123mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.95376946
124mitochondrial respiratory chain complex assembly (GO:0033108)2.91512906
125neuronal action potential (GO:0019228)2.89842198
126primary amino compound metabolic process (GO:1901160)2.89232165
127alanine transport (GO:0032328)2.82586119
128platelet dense granule organization (GO:0060155)2.82111894
129regulation of action potential (GO:0098900)2.79296774
130regulation of telomere maintenance (GO:0032204)2.79140300
131ubiquinone biosynthetic process (GO:0006744)2.79047929
132DNA methylation involved in gamete generation (GO:0043046)2.78925853
133mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.78544207
134nonmotile primary cilium assembly (GO:0035058)2.77816685
135detection of light stimulus involved in visual perception (GO:0050908)2.76144958
136detection of light stimulus involved in sensory perception (GO:0050962)2.76144958
137sulfation (GO:0051923)2.74309084
138regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.74101683
139RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.73818455
140tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.73818455
141reflex (GO:0060004)2.71527960
142neuron fate determination (GO:0048664)2.70654177
143spinal cord motor neuron differentiation (GO:0021522)2.70520222
144ATP synthesis coupled proton transport (GO:0015986)2.69558425
145energy coupled proton transport, down electrochemical gradient (GO:0015985)2.69558425
146indole-containing compound metabolic process (GO:0042430)2.68768868
147transmission of nerve impulse (GO:0019226)2.67593400
148male meiosis I (GO:0007141)2.66101441
149calcium ion-dependent exocytosis (GO:0017156)2.64629503
150synaptic transmission, cholinergic (GO:0007271)2.64118508
151renal tubule morphogenesis (GO:0061333)2.62429587
152regulation of glucokinase activity (GO:0033131)2.61496096
153regulation of hexokinase activity (GO:1903299)2.61496096
154neuron cell-cell adhesion (GO:0007158)2.61038982
155establishment of protein localization to mitochondrial membrane (GO:0090151)2.60628748
156water-soluble vitamin biosynthetic process (GO:0042364)2.58659333
157cilium organization (GO:0044782)2.55996754
158positive regulation of fatty acid transport (GO:2000193)2.54216261
159membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.53466082
160rRNA methylation (GO:0031167)2.53135411
161cilium morphogenesis (GO:0060271)2.53009318
162ubiquinone metabolic process (GO:0006743)2.52605381
163S-adenosylmethionine metabolic process (GO:0046500)2.50420928
164pyrimidine nucleobase catabolic process (GO:0006208)2.49557769
165protein-cofactor linkage (GO:0018065)2.46583365
166cilium assembly (GO:0042384)2.45636981
167serotonin metabolic process (GO:0042428)2.44719893
168presynaptic membrane assembly (GO:0097105)2.42940236
169cytidine deamination (GO:0009972)2.41204334
170cytidine metabolic process (GO:0046087)2.41204334
171cytidine catabolic process (GO:0006216)2.41204334
172membrane depolarization during action potential (GO:0086010)2.40844335
173regulation of microtubule-based movement (GO:0060632)2.40143869
174rhodopsin mediated signaling pathway (GO:0016056)2.39812204

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.99134745
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.91827658
3RXR_22158963_ChIP-Seq_LIVER_Mouse5.58127986
4EGR1_23403033_ChIP-Seq_LIVER_Mouse5.18833363
5* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.83791699
6* LXR_22158963_ChIP-Seq_LIVER_Mouse4.66929788
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.88075146
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.94798417
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.87096751
10GBX2_23144817_ChIP-Seq_PC3_Human2.82587717
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.72756499
12PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.66011564
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.56489099
14CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.47800016
15CTBP2_25329375_ChIP-Seq_LNCAP_Human2.35372021
16CTBP1_25329375_ChIP-Seq_LNCAP_Human2.33249111
17NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.30773576
18IGF1R_20145208_ChIP-Seq_DFB_Human2.20021985
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.10976378
20FUS_26573619_Chip-Seq_HEK293_Human2.05762515
21PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.04110384
22P300_19829295_ChIP-Seq_ESCs_Human1.96845650
23POU3F2_20337985_ChIP-ChIP_501MEL_Human1.86169110
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.81605085
25KAP1_22055183_ChIP-Seq_ESCs_Mouse1.80716302
26EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.74809814
27ER_23166858_ChIP-Seq_MCF-7_Human1.73833668
28BMI1_23680149_ChIP-Seq_NPCS_Mouse1.69219936
29HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.67555225
30ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.66490966
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.64685051
32EWS_26573619_Chip-Seq_HEK293_Human1.64223746
33EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.61839454
34SALL1_21062744_ChIP-ChIP_HESCs_Human1.60184719
35FLI1_27457419_Chip-Seq_LIVER_Mouse1.55752515
36STAT1_17558387_ChIP-Seq_HELA_Human1.55286248
37UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.55220383
38REST_21632747_ChIP-Seq_MESCs_Mouse1.54104306
39TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53877415
40POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.53877415
41SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.52348249
42TP53_22573176_ChIP-Seq_HFKS_Human1.51669813
43SMAD3_21741376_ChIP-Seq_EPCs_Human1.48937482
44AR_25329375_ChIP-Seq_VCAP_Human1.48666939
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47054505
46MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.46108540
47RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.45224104
48RXRA_24833708_ChIP-Seq_LIVER_Mouse1.41646211
49AR_21572438_ChIP-Seq_LNCaP_Human1.40483252
50HTT_18923047_ChIP-ChIP_STHdh_Human1.40016661
51SOX2_19829295_ChIP-Seq_ESCs_Human1.39598235
52NANOG_19829295_ChIP-Seq_ESCs_Human1.39598235
53CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.39582518
54ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.39180489
55RNF2_27304074_Chip-Seq_NSC_Mouse1.38085984
56SMAD4_21799915_ChIP-Seq_A2780_Human1.37592068
57STAT3_23295773_ChIP-Seq_U87_Human1.37435614
58EED_16625203_ChIP-ChIP_MESCs_Mouse1.36474353
59BCAT_22108803_ChIP-Seq_LS180_Human1.34677854
60TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.32631326
61NR3C1_21868756_ChIP-Seq_MCF10A_Human1.32085327
62TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31845600
63TAF15_26573619_Chip-Seq_HEK293_Human1.30227386
64EZH2_27304074_Chip-Seq_ESCs_Mouse1.29332693
65TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.28474606
66SMAD4_21741376_ChIP-Seq_EPCs_Human1.27778585
67* TCF4_23295773_ChIP-Seq_U87_Human1.27691806
68PCGF2_27294783_Chip-Seq_ESCs_Mouse1.25720609
69GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.25706559
70TCF4_22108803_ChIP-Seq_LS180_Human1.24982456
71GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24676421
72RUNX2_22187159_ChIP-Seq_PCA_Human1.24167664
73GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.23255843
74NFE2_27457419_Chip-Seq_LIVER_Mouse1.23252424
75SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.21956838
76ERA_21632823_ChIP-Seq_H3396_Human1.21884332
77FOXA1_27270436_Chip-Seq_PROSTATE_Human1.21852084
78FOXA1_25329375_ChIP-Seq_VCAP_Human1.21852084
79PIAS1_25552417_ChIP-Seq_VCAP_Human1.21155738
80ETV2_25802403_ChIP-Seq_MESCs_Mouse1.20661614
81KLF5_20875108_ChIP-Seq_MESCs_Mouse1.19983380
82KDM2B_26808549_Chip-Seq_REH_Human1.19109111
83* NCOR_22424771_ChIP-Seq_293T_Human1.18137685
84SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17680002
85CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.15866593
86PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.15664288
87GATA3_21878914_ChIP-Seq_MCF-7_Human1.15176851
88RAD21_21589869_ChIP-Seq_MESCs_Mouse1.14904484
89MYC_18940864_ChIP-ChIP_HL60_Human1.14808004
90LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.14646453
91KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.14408648
92CRX_20693478_ChIP-Seq_RETINA_Mouse1.14334233
93P53_21459846_ChIP-Seq_SAOS-2_Human1.13996795
94PRDM14_20953172_ChIP-Seq_ESCs_Human1.13631419
95IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.13428950
96CBP_20019798_ChIP-Seq_JUKART_Human1.13428950
97EZH2_27294783_Chip-Seq_ESCs_Mouse1.13330800
98VDR_22108803_ChIP-Seq_LS180_Human1.13053071
99GABP_17652178_ChIP-ChIP_JURKAT_Human1.12863432
100JARID2_20064375_ChIP-Seq_MESCs_Mouse1.12668156
101FOXA2_19822575_ChIP-Seq_HepG2_Human1.12659454
102TAL1_26923725_Chip-Seq_HPCs_Mouse1.12482642
103SOX2_22085726_ChIP-Seq_NPCs_Mouse1.12366241
104SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.12247450
105IRF1_19129219_ChIP-ChIP_H3396_Human1.11350342
106RARA_24833708_ChIP-Seq_LIVER_Mouse1.10686560
107FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09133104
108TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09125326
109EZH2_22144423_ChIP-Seq_EOC_Human1.09078504
110NANOG_20526341_ChIP-Seq_ESCs_Human1.08431310
111ELK4_26923725_Chip-Seq_MESODERM_Mouse1.07722110
112MYC_19829295_ChIP-Seq_ESCs_Human1.06988457
113ZNF274_21170338_ChIP-Seq_K562_Hela1.06849413
114PCGF2_27294783_Chip-Seq_NPCs_Mouse1.06593293
115FOXA1_21572438_ChIP-Seq_LNCaP_Human1.06112259
116SUZ12_27294783_Chip-Seq_ESCs_Mouse1.05679635
117GATA3_21867929_ChIP-Seq_CD8_Mouse1.04337498
118SMAD3_21741376_ChIP-Seq_ESCs_Human1.03334647
119WDR5_24793694_ChIP-Seq_LNCAP_Human1.03253280
120POU5F1_16153702_ChIP-ChIP_HESCs_Human1.02637502
121ESET_19884257_ChIP-Seq_ESCs_Mouse1.02360970
122SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.02338713
123EZH2_27294783_Chip-Seq_NPCs_Mouse1.02145043
124GATA3_21867929_ChIP-Seq_TH1_Mouse1.01429285
125TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01039593
126REST_18959480_ChIP-ChIP_MESCs_Mouse1.00184480
127SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.99662856
128AR_20517297_ChIP-Seq_VCAP_Human0.99354846
129HOXB7_26014856_ChIP-Seq_BT474_Human0.98777374
130MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98703267
131AUTS2_25519132_ChIP-Seq_293T-REX_Human0.98682015
132NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.98362678
133OCT4_21477851_ChIP-Seq_ESCs_Mouse0.98195886
134STAT3_18555785_Chip-Seq_ESCs_Mouse0.97451483
135EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.96570177
136* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.96218122
137* HNF4A_19822575_ChIP-Seq_HepG2_Human0.95419120
138FLI1_21867929_ChIP-Seq_TH2_Mouse0.95222011
139SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.94261090
140CBX2_27304074_Chip-Seq_ESCs_Mouse0.94043514
141SPI1_26923725_Chip-Seq_HPCs_Mouse0.90244834
142OCT4_18555785_Chip-Seq_ESCs_Mouse0.87940836
143ERG_20517297_ChIP-Seq_VCAP_Human0.87766143
144EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.87555493
145TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.85746254
146ZFP57_27257070_Chip-Seq_ESCs_Mouse0.84673898
147EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.83624033
148* CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82640526
149SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.81964933
150GF1_26923725_Chip-Seq_HPCs_Mouse0.81919260
151EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.81815688
152CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.81298549
153MYC_27129775_Chip-Seq_CORNEA_Mouse0.80922704
154ESRRB_18555785_Chip-Seq_ESCs_Mouse0.80866501
155P53_22387025_ChIP-Seq_ESCs_Mouse0.79835573
156FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.79324127
157MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.78911644
158PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.78588247
159Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.77805269
160IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.77409006
161NANOG_18555785_Chip-Seq_ESCs_Mouse0.77241747
162MYC_19915707_ChIP-ChIP_AK7_Human0.77169542
163RUNX1_27457419_Chip-Seq_LIVER_Mouse0.76909807
164SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.76310424
165P300_18555785_Chip-Seq_ESCs_Mouse0.76135961
166PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.75796154
167NFIB_24661679_ChIP-Seq_LUNG_Mouse0.74234764
168NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.73789752
169PU1_27457419_Chip-Seq_LIVER_Mouse0.73681624
170KLF4_18555785_Chip-Seq_ESCs_Mouse0.73370214
171AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.73222767
172CMYC_18555785_Chip-Seq_ESCs_Mouse0.72843420
173RUNX1_26923725_Chip-Seq_HPCs_Mouse0.72810209

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization7.86902208
2MP0002139_abnormal_hepatobiliary_system7.57994080
3MP0005360_urolithiasis6.62002258
4MP0005085_abnormal_gallbladder_physiolo5.65324700
5MP0005365_abnormal_bile_salt5.58219921
6MP0008875_abnormal_xenobiotic_pharmacok4.43293350
7MP0003252_abnormal_bile_duct3.62011289
8MP0003806_abnormal_nucleotide_metabolis3.58966266
9MP0010329_abnormal_lipoprotein_level3.09719434
10MP0003698_abnormal_male_reproductive2.80606707
11MP0003136_yellow_coat_color2.59314623
12MP0001968_abnormal_touch/_nociception2.58352303
13MP0001929_abnormal_gametogenesis2.52897021
14MP0005083_abnormal_biliary_tract2.49930633
15MP0003195_calcinosis2.36387877
16MP0005332_abnormal_amino_acid2.34621732
17MP0003878_abnormal_ear_physiology2.30221116
18MP0005377_hearing/vestibular/ear_phenot2.30221116
19MP0009840_abnormal_foam_cell2.28647290
20MP0005551_abnormal_eye_electrophysiolog2.28588325
21MP0004019_abnormal_vitamin_homeostasis2.12836178
22MP0002163_abnormal_gland_morphology2.10564527
23MP0001666_abnormal_nutrient_absorption2.10275253
24MP0004885_abnormal_endolymph2.10261024
25MP0005379_endocrine/exocrine_gland_phen2.05397248
26MP0003880_abnormal_central_pattern2.03644124
27MP0004133_heterotaxia2.01778857
28MP0002736_abnormal_nociception_after2.01099150
29MP0006292_abnormal_olfactory_placode1.99153994
30MP0009745_abnormal_behavioral_response1.96291658
31MP0004742_abnormal_vestibular_system1.94457022
32MP0002735_abnormal_chemical_nociception1.94418550
33MP0000609_abnormal_liver_physiology1.89444731
34MP0002118_abnormal_lipid_homeostasis1.89258995
35MP0005670_abnormal_white_adipose1.87123015
36MP0001485_abnormal_pinna_reflex1.86241425
37MP0006072_abnormal_retinal_apoptosis1.85288937
38MP0009046_muscle_twitch1.83663238
39MP0001986_abnormal_taste_sensitivity1.79019601
40MP0002638_abnormal_pupillary_reflex1.78623343
41MP0003787_abnormal_imprinting1.77923313
42MP0003283_abnormal_digestive_organ1.71799527
43MP0005647_abnormal_sex_gland1.70424822
44MP0005319_abnormal_enzyme/_coenzyme1.68957935
45MP0004147_increased_porphyrin_level1.68298919
46MP0001764_abnormal_homeostasis1.66897019
47MP0002272_abnormal_nervous_system1.66735860
48MP0006276_abnormal_autonomic_nervous1.66724456
49MP0002138_abnormal_hepatobiliary_system1.64498876
50MP0003868_abnormal_feces_composition1.64409367
51MP0004142_abnormal_muscle_tone1.63069679
52MP0003191_abnormal_cellular_cholesterol1.62685762
53MP0002102_abnormal_ear_morphology1.61054742
54MP0002161_abnormal_fertility/fecundity1.59220236
55MP0003011_delayed_dark_adaptation1.54672327
56MP0005645_abnormal_hypothalamus_physiol1.50988912
57MP0010386_abnormal_urinary_bladder1.48606660
58MP0005646_abnormal_pituitary_gland1.44757119
59MP0005253_abnormal_eye_physiology1.44658233
60MP0001486_abnormal_startle_reflex1.44241769
61MP0002210_abnormal_sex_determination1.42566132
62MP0002572_abnormal_emotion/affect_behav1.41821281
63MP0000631_abnormal_neuroendocrine_gland1.39829107
64MP0001970_abnormal_pain_threshold1.37088688
65MP0002733_abnormal_thermal_nociception1.36444959
66MP0005584_abnormal_enzyme/coenzyme_acti1.34774883
67MP0008877_abnormal_DNA_methylation1.33556587
68MP0009697_abnormal_copulation1.32517011
69MP0002064_seizures1.31717669
70MP0002234_abnormal_pharynx_morphology1.30848872
71MP0002938_white_spotting1.29234689
72MP0002557_abnormal_social/conspecific_i1.27081230
73MP0001905_abnormal_dopamine_level1.23749502
74MP0001145_abnormal_male_reproductive1.23359273
75MP0009379_abnormal_foot_pigmentation1.20820508
76MP0000372_irregular_coat_pigmentation1.20483820
77MP0003635_abnormal_synaptic_transmissio1.20359106
78MP0005636_abnormal_mineral_homeostasis1.18876215
79MP0000569_abnormal_digit_pigmentation1.16979209
80MP0002067_abnormal_sensory_capabilities1.15606584
81MP0000653_abnormal_sex_gland1.14569926
82MP0000538_abnormal_urinary_bladder1.12370405
83MP0005451_abnormal_body_composition1.10777932
84MP0002734_abnormal_mechanical_nocicepti1.09933691
85MP0000026_abnormal_inner_ear1.08947175
86MP0005195_abnormal_posterior_eye1.08708165
87MP0003718_maternal_effect1.08202979
88MP0002063_abnormal_learning/memory/cond1.07379859
89MP0002095_abnormal_skin_pigmentation1.06305840
90MP0009643_abnormal_urine_homeostasis1.04571118
91MP0002693_abnormal_pancreas_physiology1.00659206
92MP0000598_abnormal_liver_morphology0.99712663
93MP0004924_abnormal_behavior0.99206959
94MP0005386_behavior/neurological_phenoty0.99206959
95MP0000230_abnormal_systemic_arterial0.97499612
96MP0000778_abnormal_nervous_system0.96839464
97MP0005423_abnormal_somatic_nervous0.96671577
98MP0002277_abnormal_respiratory_mucosa0.96253959
99MP0003119_abnormal_digestive_system0.95157033
100MP0001963_abnormal_hearing_physiology0.95055075
101MP0002653_abnormal_ependyma_morphology0.94352679
102MP0000604_amyloidosis0.94183263
103MP0005167_abnormal_blood-brain_barrier0.90786067
104MP0001919_abnormal_reproductive_system0.89981027
105MP0000049_abnormal_middle_ear0.89891535
106MP0005174_abnormal_tail_pigmentation0.89680721
107MP0006036_abnormal_mitochondrial_physio0.85094416
108MP0002752_abnormal_somatic_nervous0.84859566
109MP0003705_abnormal_hypodermis_morpholog0.84326945
110MP0001440_abnormal_grooming_behavior0.83972568
111MP0002184_abnormal_innervation0.83215921
112MP0001765_abnormal_ion_homeostasis0.82810688
113MP0003656_abnormal_erythrocyte_physiolo0.82330974
114MP0002928_abnormal_bile_duct0.82177355
115MP0001501_abnormal_sleep_pattern0.81250720
116MP0003186_abnormal_redox_activity0.80880268
117MP0002971_abnormal_brown_adipose0.80830685
118MP0001944_abnormal_pancreas_morphology0.80668503
119MP0002229_neurodegeneration0.79662873
120MP0009763_increased_sensitivity_to0.78142525
121MP0003137_abnormal_impulse_conducting0.77559588
122MP0009642_abnormal_blood_homeostasis0.77221494
123MP0004145_abnormal_muscle_electrophysio0.76497241
124MP0008775_abnormal_heart_ventricle0.76240150
125MP0008469_abnormal_protein_level0.74934421
126MP0000955_abnormal_spinal_cord0.74744208
127MP0008995_early_reproductive_senescence0.74140526
128MP0000516_abnormal_urinary_system0.73806175
129MP0002254_reproductive_system_inflammat0.73391348
130MP0009764_decreased_sensitivity_to0.71650506
131MP0002282_abnormal_trachea_morphology0.71269900
132MP0001661_extended_life_span0.69512305
133MP0005535_abnormal_body_temperature0.69263923
134MP0003329_amyloid_beta_deposits0.66318163
135MP0005084_abnormal_gallbladder_morpholo0.66068593
136MP0010368_abnormal_lymphatic_system0.65850952
137MP0005376_homeostasis/metabolism_phenot0.63968973
138MP0002078_abnormal_glucose_homeostasis0.62599047
139MP0004130_abnormal_muscle_cell0.62002840
140MP0006035_abnormal_mitochondrial_morpho0.60995711
141MP0002160_abnormal_reproductive_system0.60700267
142MP0005334_abnormal_fat_pad0.59338629
143MP0005666_abnormal_adipose_tissue0.57464085
144MP0002876_abnormal_thyroid_physiology0.55388862
145MP0005266_abnormal_metabolism0.54998262
146MP0005408_hypopigmentation0.48466031
147MP0009765_abnormal_xenobiotic_induced0.46263383
148MP0009115_abnormal_fat_cell0.44583168
149MP0005220_abnormal_exocrine_pancreas0.44388211
150MP0000639_abnormal_adrenal_gland0.43515413
151MP0003690_abnormal_glial_cell0.41721165
152MP0001324_abnormal_eye_pigmentation0.41713336
153MP0001756_abnormal_urination0.41420606
154MP0002136_abnormal_kidney_physiology0.40508391
155MP0003699_abnormal_female_reproductive0.40306990
156MP0003953_abnormal_hormone_level0.39439771
157MP0002796_impaired_skin_barrier0.38961835
158MP0005448_abnormal_energy_balance0.37515995
159MP0009053_abnormal_anal_canal0.37345021
160MP0000427_abnormal_hair_cycle0.33994001
161MP0001984_abnormal_olfaction0.33843716
162MP0000579_abnormal_nail_morphology0.33613468
163MP0009672_abnormal_birth_weight0.32471051
164MP0004381_abnormal_hair_follicle0.32459603
165MP0002269_muscular_atrophy0.32039816
166MP0005395_other_phenotype0.31566350
167MP0005389_reproductive_system_phenotype0.30837245
168MP0002970_abnormal_white_adipose0.30717796
169MP0002822_catalepsy0.30446362
170MP0008873_increased_physiological_sensi0.28618214
171MP0002132_abnormal_respiratory_system0.26724515
172MP0004043_abnormal_pH_regulation0.26040522
173MP0003646_muscle_fatigue0.25753758
174MP0008872_abnormal_physiological_respon0.25744004
175MP0002837_dystrophic_cardiac_calcinosis0.25582806
176MP0005166_decreased_susceptibility_to0.23879110
177MP0006082_CNS_inflammation0.23710219
178MP0008874_decreased_physiological_sensi0.23699932

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)8.76851537
2Absent/shortened dynein arms (HP:0200106)8.76851537
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.65835014
4Abnormal respiratory motile cilium physiology (HP:0012261)5.97850632
5Abnormal respiratory motile cilium morphology (HP:0005938)5.79383886
6Abnormal respiratory epithelium morphology (HP:0012253)5.79383886
7Intrahepatic cholestasis (HP:0001406)5.78157245
8Deep venous thrombosis (HP:0002625)5.60379814
9Abnormality of aromatic amino acid family metabolism (HP:0004338)5.47694170
10Abnormality of monocarboxylic acid metabolism (HP:0010996)5.01006415
11Prolonged partial thromboplastin time (HP:0003645)4.95555008
12Hypobetalipoproteinemia (HP:0003563)4.90011817
13Chronic bronchitis (HP:0004469)4.87756570
14Abnormal ciliary motility (HP:0012262)4.85287795
15Complement deficiency (HP:0004431)4.82371716
16Rhinitis (HP:0012384)4.77996515
17Xanthomatosis (HP:0000991)4.69859859
18Pancreatic cysts (HP:0001737)4.34163217
19Infertility (HP:0000789)4.31524286
20Abnormality of midbrain morphology (HP:0002418)4.21355634
21Molar tooth sign on MRI (HP:0002419)4.21355634
22Pancreatic fibrosis (HP:0100732)4.20253430
23Nasal polyposis (HP:0100582)4.19925686
24Hyperlipoproteinemia (HP:0010980)4.07381786
25True hermaphroditism (HP:0010459)4.03066430
26Epidermoid cyst (HP:0200040)3.85895162
27Congenital stationary night blindness (HP:0007642)3.85168040
28Hypolipoproteinemia (HP:0010981)3.75947085
29Abnormality of complement system (HP:0005339)3.60545745
30Abnormality of the nasal mucosa (HP:0000433)3.48070358
31Abnormal rod and cone electroretinograms (HP:0008323)3.42207839
32Joint hemorrhage (HP:0005261)3.39442501
33Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.39423643
34Hypoalphalipoproteinemia (HP:0003233)3.38038879
35Abnormality of the renal medulla (HP:0100957)3.36275257
36Ketosis (HP:0001946)3.33898281
37Hypercholesterolemia (HP:0003124)3.31034564
38Hyperammonemia (HP:0001987)3.30486399
39Type II lissencephaly (HP:0007260)3.28920002
40Pendular nystagmus (HP:0012043)3.28129679
41Attenuation of retinal blood vessels (HP:0007843)3.24257800
42Hyperglycinemia (HP:0002154)3.24175180
43Fat malabsorption (HP:0002630)3.20219334
44Abnormality of glutamine family amino acid metabolism (HP:0010902)3.08297791
45Abnormality of sulfur amino acid metabolism (HP:0004339)3.06128840
46Abnormality of the common coagulation pathway (HP:0010990)3.03391572
47Abnormal gallbladder physiology (HP:0012438)3.01676351
48Cholecystitis (HP:0001082)3.01676351
49Abnormal drinking behavior (HP:0030082)3.01447539
50Polydipsia (HP:0001959)3.01447539
51Abnormality of aspartate family amino acid metabolism (HP:0010899)2.99682499
52Chronic hepatic failure (HP:0100626)2.97646241
53Abnormality of methionine metabolism (HP:0010901)2.96910310
54Vascular calcification (HP:0004934)2.87219672
55Bronchitis (HP:0012387)2.83781171
56Recurrent sinusitis (HP:0011108)2.82269211
57Tubular atrophy (HP:0000092)2.78812654
58Abnormality of serine family amino acid metabolism (HP:0010894)2.76373531
59Abnormality of glycine metabolism (HP:0010895)2.76373531
60Abnormality of the intrinsic pathway (HP:0010989)2.75061182
61Abnormality of pyrimidine metabolism (HP:0004353)2.74995429
62Hyperglycinuria (HP:0003108)2.74564734
63Cystic liver disease (HP:0006706)2.73704226
64Spontaneous abortion (HP:0005268)2.71846296
65Congenital, generalized hypertrichosis (HP:0004540)2.70230683
66Bony spicule pigmentary retinopathy (HP:0007737)2.68119380
67Increased corneal curvature (HP:0100692)2.67677581
68Keratoconus (HP:0000563)2.67677581
69Bronchiectasis (HP:0002110)2.66617370
70Male infertility (HP:0003251)2.64849634
71Conjugated hyperbilirubinemia (HP:0002908)2.62980723
72Large for gestational age (HP:0001520)2.60625020
73Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.59426300
74Hyperventilation (HP:0002883)2.59116649
75Severe visual impairment (HP:0001141)2.58693896
76Cardiovascular calcification (HP:0011915)2.55279770
77Abnormal spermatogenesis (HP:0008669)2.54387185
78Abnormality of the pons (HP:0007361)2.53218550
79Sclerocornea (HP:0000647)2.53177730
80Hypoplasia of the pons (HP:0012110)2.51582771
81Hypoglycemic coma (HP:0001325)2.50545809
82Abolished electroretinogram (ERG) (HP:0000550)2.48982360
83Hemorrhage of the eye (HP:0011885)2.43175541
84Renal Fanconi syndrome (HP:0001994)2.43091434
85Polyuria (HP:0000103)2.42766464
86Mitochondrial inheritance (HP:0001427)2.42644309
87Absent rod-and cone-mediated responses on ERG (HP:0007688)2.42035041
88Decreased central vision (HP:0007663)2.41598567
89Hyperbilirubinemia (HP:0002904)2.41228655
90Abnormality of nucleobase metabolism (HP:0010932)2.40398832
91Abnormality of fatty-acid metabolism (HP:0004359)2.40124454
92Steatorrhea (HP:0002570)2.36950900
93Recurrent otitis media (HP:0000403)2.30394325
94Recurrent gram-negative bacterial infections (HP:0005420)2.30373759
95Anencephaly (HP:0002323)2.30308780
96Myocardial infarction (HP:0001658)2.29936539
97Acanthocytosis (HP:0001927)2.28297643
98Cerebellar dysplasia (HP:0007033)2.26037921
99Progressive cerebellar ataxia (HP:0002073)2.24521145
100Male pseudohermaphroditism (HP:0000037)2.23880704
101Inability to walk (HP:0002540)2.23657064
102Abnormality of purine metabolism (HP:0004352)2.23100533
103Acute necrotizing encephalopathy (HP:0006965)2.21906970
104Increased CSF lactate (HP:0002490)2.21270919
105Bile duct proliferation (HP:0001408)2.18814805
106Abnormal biliary tract physiology (HP:0012439)2.18814805
107Gout (HP:0001997)2.18154276
108Optic nerve hypoplasia (HP:0000609)2.17274840
109Nephronophthisis (HP:0000090)2.16294542
110Furrowed tongue (HP:0000221)2.15785813
111Azoospermia (HP:0000027)2.15200492
112Medial flaring of the eyebrow (HP:0010747)2.15101299
113Malnutrition (HP:0004395)2.13357796
114Congenital hepatic fibrosis (HP:0002612)2.13344083
115Gastrointestinal atresia (HP:0002589)2.12777758
116Increased hepatocellular lipid droplets (HP:0006565)2.12641283
117Systemic lupus erythematosus (HP:0002725)2.11073668
118Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.10975892
119Abnormal urine output (HP:0012590)2.10445545
120Bilateral microphthalmos (HP:0007633)2.10041601
121Aplasia/Hypoplasia of the tongue (HP:0010295)2.09874447
122Abnormality of serum amino acid levels (HP:0003112)2.09793639
123Lissencephaly (HP:0001339)2.07455593
124Progressive macrocephaly (HP:0004481)2.07099798
125Abnormality of the lower motor neuron (HP:0002366)2.06199419
126Tubulointerstitial nephritis (HP:0001970)2.05907813
127Delayed CNS myelination (HP:0002188)2.04123559
1283-Methylglutaconic aciduria (HP:0003535)2.03742865
129Hepatocellular carcinoma (HP:0001402)2.02617108
130Ketoacidosis (HP:0001993)2.02403417
131Spastic tetraparesis (HP:0001285)1.99088885
132Optic disc pallor (HP:0000543)1.98890143
133Hypothermia (HP:0002045)1.97555720
134Broad-based gait (HP:0002136)1.95728779
135Gonadotropin excess (HP:0000837)1.95541278
136Concave nail (HP:0001598)1.95149790
137Acute encephalopathy (HP:0006846)1.94564040
138Abnormal albumin level (HP:0012116)1.94259038
139Hypoalbuminemia (HP:0003073)1.94259038
140Impulsivity (HP:0100710)1.92769231
141Renal cortical cysts (HP:0000803)1.91606821
142Abnormal gallbladder morphology (HP:0012437)1.90859815
143Skin nodule (HP:0200036)1.90755328
144Lipid accumulation in hepatocytes (HP:0006561)1.90688761
145Severe muscular hypotonia (HP:0006829)1.90444534
146Intestinal atresia (HP:0011100)1.90299362
147Glycosuria (HP:0003076)1.89950168
148Abnormality of urine glucose concentration (HP:0011016)1.89950168
149Focal motor seizures (HP:0011153)1.89893304
150Esophageal atresia (HP:0002032)1.89840861
151Dicarboxylic aciduria (HP:0003215)1.89804079
152Abnormality of dicarboxylic acid metabolism (HP:0010995)1.89804079
153Abnormality of the renal cortex (HP:0011035)1.89422435
154Metabolic acidosis (HP:0001942)1.89407530
155Cholelithiasis (HP:0001081)1.89019865
156Tubulointerstitial abnormality (HP:0001969)1.88836835
157Abnormality of macular pigmentation (HP:0008002)1.87967210
158Gaze-evoked nystagmus (HP:0000640)1.87535075
159Aplasia/Hypoplasia of the fovea (HP:0008060)1.87392036
160Hypoplasia of the fovea (HP:0007750)1.87392036
161Hypochromic microcytic anemia (HP:0004840)1.84330985
162Abnormality of renal resorption (HP:0011038)1.83958276
163Abnormality of renal excretion (HP:0011036)1.83013273
164Upper motor neuron abnormality (HP:0002127)1.82672426
165Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.80604507
166Patellar aplasia (HP:0006443)1.79614975
167Febrile seizures (HP:0002373)1.79445826
168Enlarged kidneys (HP:0000105)1.78692770
169Dyskinesia (HP:0100660)1.78534432
170Chorioretinal atrophy (HP:0000533)1.78016135
171Occipital encephalocele (HP:0002085)1.77393805
172Abnormal mitochondria in muscle tissue (HP:0008316)1.77349441
173Hepatocellular necrosis (HP:0001404)1.77255725
174Decreased circulating renin level (HP:0003351)1.77012808
175Hyperinsulinemic hypoglycemia (HP:0000825)1.75888126
176Lethargy (HP:0001254)1.74849396
177Aplasia/hypoplasia of the uterus (HP:0008684)1.74167553
178Hepatic necrosis (HP:0002605)1.71455064
179Increased purine levels (HP:0004368)1.71129265
180Hyperuricemia (HP:0002149)1.71129265
181Abnormal number of erythroid precursors (HP:0012131)1.70306928
182Pancreatitis (HP:0001733)1.69934050
183Abnormality of the gallbladder (HP:0005264)1.69848175
184Genetic anticipation (HP:0003743)1.68826019
185Aplasia/Hypoplasia of the patella (HP:0006498)1.68789442
186Brushfield spots (HP:0001088)1.68735965
187Irritability (HP:0000737)1.68488248
188Hemiparesis (HP:0001269)1.68107669
189Anophthalmia (HP:0000528)1.67820730
190Abnormality of the fovea (HP:0000493)1.67618912

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.34942231
2PDK48.34942231
3PDK25.32092980
4TESK13.63084691
5ICK3.29125018
6PRKD33.22882886
7ADRBK23.11954960
8MAP4K22.99695411
9BCKDK2.85639826
10BMPR1B2.66519814
11TLK12.57442820
12TNIK2.24541926
13TXK2.06813502
14NUAK12.03790984
15ZAK2.02696527
16WNK41.99772170
17ERN11.99037361
18PTK2B1.93357720
19ACVR1B1.89431931
20FGFR41.85910351
21CASK1.77133991
22VRK11.72696713
23MAPK131.72268674
24SIK21.68619566
25SIK11.66804596
26PNCK1.64953851
27STK391.63534977
28MARK11.46680310
29ERBB41.44947902
30DYRK1B1.42563110
31OXSR11.41283667
32TAOK21.35778423
33MAP3K41.32454639
34MAPK151.29527389
35STK381.21369884
36LIMK11.19821127
37WEE11.18899546
38TAOK31.17398131
39MAP2K71.16618537
40INSRR1.13170322
41MUSK1.07867900
42PLK21.06144883
43PHKG21.05357642
44PHKG11.05357642
45PDK11.04788595
46DYRK21.04356475
47CSNK1G11.02539838
48TGFBR11.00653478
49ADRBK11.00389920
50TSSK60.99266984
51VRK20.98812477
52MAP2K60.94119015
53MAP2K40.93890078
54STK38L0.92900456
55PAK30.91288007
56NTRK30.91238506
57MST1R0.89810653
58NEK20.87388152
59LATS10.86838112
60PIK3CA0.85241100
61CAMK1G0.85032944
62PINK10.84540162
63IRAK10.83185626
64PRKCE0.81230620
65CSNK1G20.80959345
66PIK3CG0.80205647
67FRK0.79682220
68MKNK20.73180839
69STK30.71941967
70MAPK110.71854971
71NTRK20.71578504
72NLK0.71506347
73CSNK1G30.71406542
74CDK30.69871248
75TYRO30.67521995
76NME10.66822541
77TEC0.66592724
78PLK30.64882736
79PDPK10.64461975
80BRSK20.63790780
81EPHA40.63128607
82PTK60.60588145
83CAMKK20.59417130
84MAP3K100.59157692
85MAPKAPK30.58847124
86TRIM280.56413806
87GRK70.53363524
88BCR0.52983743
89CAMK2A0.52405080
90PRKAA10.51416835
91TESK20.51315564
92TRIB30.51100041
93FGFR20.50817496
94PKN10.50590565
95PRKCZ0.49900943
96MINK10.47944983
97CSNK1A10.46366251
98STK110.45606770
99DAPK20.45335359
100WNK10.44528758
101PRKACA0.43438223
102PRKAA20.43270790
103MTOR0.42388795
104IRAK20.41966891
105CDK60.41744295
106TYK20.40202297
107PRKACG0.40085711
108IKBKB0.39953152
109RIPK10.39256863
110PRKCH0.37937546
111PRKCG0.37448089
112CSNK1A1L0.37175822
113DYRK30.37151949
114MAPKAPK50.36689711
115CAMK10.36464328
116ITK0.36305827
117MAPK40.35781453
118ERBB30.35678482
119NEK90.34904252
120LMTK20.34876410
121OBSCN0.34150768
122ABL20.34098100
123EPHB10.33537770
124JAK20.33411435
125ERBB20.33049374
126DYRK1A0.31858778
127PRKCQ0.31394830
128TBK10.30988475
129ROCK10.30242676
130RPS6KA50.28145804
131GSK3A0.27332257
132KDR0.27201888
133FLT30.25838565
134PKN20.25627977
135CAMK2G0.24027784
136MAP3K70.23867902
137MET0.23652095
138CSK0.23502186
139MST40.23434213
140DDR20.23124664
141CSF1R0.21722146
142TTK0.21197753
143PLK40.21060887
144GRK60.20241647
145TIE10.20001607
146EGFR0.19246653
147CDK40.18699201
148PAK20.17836359
149MAP3K50.16768700
150JAK10.16527422
151WNK30.15838082
152RPS6KB10.14934892
153MAP3K30.14831368
154CDK120.13670433
155CSNK1D0.12919759
156CAMK1D0.12172943
157GRK10.12051925
158PRKG10.11769749
159CHEK20.11437336
160IGF1R0.10837269
161PRKCA0.10737354
162CAMKK10.10516317
163PASK0.09743324
164ATM0.08682190
165CHEK10.08553432
166MAPK70.07233802
167PTK20.07135767
168CCNB10.06839486

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.30424209
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.07424456
3Nitrogen metabolism_Homo sapiens_hsa009103.05511588
4Phototransduction_Homo sapiens_hsa047442.98292457
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.97841883
6Propanoate metabolism_Homo sapiens_hsa006402.69980146
7Oxidative phosphorylation_Homo sapiens_hsa001902.67216901
8Fatty acid degradation_Homo sapiens_hsa000712.64058316
9Complement and coagulation cascades_Homo sapiens_hsa046102.57889028
10Arginine biosynthesis_Homo sapiens_hsa002202.56117622
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.49839212
12Tryptophan metabolism_Homo sapiens_hsa003802.46925020
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.46239176
14Pyruvate metabolism_Homo sapiens_hsa006202.31352088
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.29543440
16PPAR signaling pathway_Homo sapiens_hsa033202.23253076
17Vitamin B6 metabolism_Homo sapiens_hsa007502.20085089
18Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.18803523
19Pentose and glucuronate interconversions_Homo sapiens_hsa000402.18412839
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.16918783
21Nicotine addiction_Homo sapiens_hsa050332.15923537
22Selenocompound metabolism_Homo sapiens_hsa004502.09636022
23Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.03469574
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.03412318
25Parkinsons disease_Homo sapiens_hsa050122.01708430
26Fatty acid metabolism_Homo sapiens_hsa012121.96979241
27Peroxisome_Homo sapiens_hsa041461.96803500
28Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.94016449
29Chemical carcinogenesis_Homo sapiens_hsa052041.93849529
30Steroid hormone biosynthesis_Homo sapiens_hsa001401.89202096
31Butanoate metabolism_Homo sapiens_hsa006501.88238605
32Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.80585251
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.73092628
34Olfactory transduction_Homo sapiens_hsa047401.68217499
35Histidine metabolism_Homo sapiens_hsa003401.66192121
36Retinol metabolism_Homo sapiens_hsa008301.64850536
37Cardiac muscle contraction_Homo sapiens_hsa042601.62500102
38Ribosome_Homo sapiens_hsa030101.61249789
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.59909924
40Taste transduction_Homo sapiens_hsa047421.59401870
41Bile secretion_Homo sapiens_hsa049761.55694318
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.51158803
43Protein export_Homo sapiens_hsa030601.49007783
44Drug metabolism - other enzymes_Homo sapiens_hsa009831.48024864
45Fatty acid biosynthesis_Homo sapiens_hsa000611.47091365
46Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.46460454
47Staphylococcus aureus infection_Homo sapiens_hsa051501.46114788
48beta-Alanine metabolism_Homo sapiens_hsa004101.45317976
49Carbon metabolism_Homo sapiens_hsa012001.41485553
50Alzheimers disease_Homo sapiens_hsa050101.41185735
51Phenylalanine metabolism_Homo sapiens_hsa003601.40229923
52Caffeine metabolism_Homo sapiens_hsa002321.39993750
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.37165009
54Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.33587964
55Biosynthesis of amino acids_Homo sapiens_hsa012301.33297121
56Sulfur metabolism_Homo sapiens_hsa009201.29282121
57Fat digestion and absorption_Homo sapiens_hsa049751.28622294
58Tyrosine metabolism_Homo sapiens_hsa003501.28495112
59ABC transporters_Homo sapiens_hsa020101.28024770
60Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.22115551
61RNA polymerase_Homo sapiens_hsa030201.18491160
62Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.18338029
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.16782762
64Fatty acid elongation_Homo sapiens_hsa000621.16303338
65Morphine addiction_Homo sapiens_hsa050321.15572390
66Glycerolipid metabolism_Homo sapiens_hsa005611.14522662
67Pentose phosphate pathway_Homo sapiens_hsa000301.10206180
68Starch and sucrose metabolism_Homo sapiens_hsa005001.09964089
69Intestinal immune network for IgA production_Homo sapiens_hsa046721.09353096
70Homologous recombination_Homo sapiens_hsa034401.07781114
71Fanconi anemia pathway_Homo sapiens_hsa034601.00712022
722-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.00367716
73Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.99523884
74Insulin secretion_Homo sapiens_hsa049110.96651982
75Type I diabetes mellitus_Homo sapiens_hsa049400.96486111
76Steroid biosynthesis_Homo sapiens_hsa001000.94481031
77Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.92746982
78Circadian entrainment_Homo sapiens_hsa047130.89146579
79Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.88325763
80Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87079004
81Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.86424981
82alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.85542645
83Glutamatergic synapse_Homo sapiens_hsa047240.85503439
84GABAergic synapse_Homo sapiens_hsa047270.84929700
85Maturity onset diabetes of the young_Homo sapiens_hsa049500.84811363
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.83438872
87Primary immunodeficiency_Homo sapiens_hsa053400.82625012
88Vitamin digestion and absorption_Homo sapiens_hsa049770.81024788
89Glutathione metabolism_Homo sapiens_hsa004800.80981695
90Cocaine addiction_Homo sapiens_hsa050300.79288985
91Asthma_Homo sapiens_hsa053100.79074143
92Glucagon signaling pathway_Homo sapiens_hsa049220.78050939
93Folate biosynthesis_Homo sapiens_hsa007900.77342869
94Linoleic acid metabolism_Homo sapiens_hsa005910.77062397
95Serotonergic synapse_Homo sapiens_hsa047260.76434675
96Cyanoamino acid metabolism_Homo sapiens_hsa004600.74018572
97RNA degradation_Homo sapiens_hsa030180.73920609
98Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.73671113
99Sulfur relay system_Homo sapiens_hsa041220.73540907
100Autoimmune thyroid disease_Homo sapiens_hsa053200.73238166
101Allograft rejection_Homo sapiens_hsa053300.71782435
102Arginine and proline metabolism_Homo sapiens_hsa003300.71738926
103Graft-versus-host disease_Homo sapiens_hsa053320.70941057
104Lysine degradation_Homo sapiens_hsa003100.70887677
105Salivary secretion_Homo sapiens_hsa049700.68722367
106Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.68157043
107Pyrimidine metabolism_Homo sapiens_hsa002400.63830009
108Collecting duct acid secretion_Homo sapiens_hsa049660.62298921
109Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.60553380
110Regulation of autophagy_Homo sapiens_hsa041400.59753674
111Calcium signaling pathway_Homo sapiens_hsa040200.57823870
112Fructose and mannose metabolism_Homo sapiens_hsa000510.56757280
113Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.55087235
114Proteasome_Homo sapiens_hsa030500.54985462
115Metabolic pathways_Homo sapiens_hsa011000.54381260
116Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.53569582
117Hematopoietic cell lineage_Homo sapiens_hsa046400.52222900
118Amphetamine addiction_Homo sapiens_hsa050310.49074179
119Glycerophospholipid metabolism_Homo sapiens_hsa005640.48453202
120Glycosaminoglycan degradation_Homo sapiens_hsa005310.48137765
121Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.46717941
122Vascular smooth muscle contraction_Homo sapiens_hsa042700.43698714
123Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42195560
124Hedgehog signaling pathway_Homo sapiens_hsa043400.41022951
125cAMP signaling pathway_Homo sapiens_hsa040240.40759880
126One carbon pool by folate_Homo sapiens_hsa006700.35391523
127Adipocytokine signaling pathway_Homo sapiens_hsa049200.35161037
128Prion diseases_Homo sapiens_hsa050200.33283797
129Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.31425704
130Carbohydrate digestion and absorption_Homo sapiens_hsa049730.30861409
131Insulin resistance_Homo sapiens_hsa049310.19874864
132Galactose metabolism_Homo sapiens_hsa000520.14309337
133AMPK signaling pathway_Homo sapiens_hsa041520.10239372
134Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.10078160
135Dorso-ventral axis formation_Homo sapiens_hsa043200.08685451
136Mineral absorption_Homo sapiens_hsa049780.06976800
137Ether lipid metabolism_Homo sapiens_hsa005650.03627595
138Central carbon metabolism in cancer_Homo sapiens_hsa052300.00136742
139Insulin signaling pathway_Homo sapiens_hsa04910-0.1583592
140Protein digestion and absorption_Homo sapiens_hsa04974-0.1417842
141Purine metabolism_Homo sapiens_hsa00230-0.1398803
142Basal transcription factors_Homo sapiens_hsa03022-0.1360498
143Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.1333475
144Huntingtons disease_Homo sapiens_hsa05016-0.1220259
145Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014-0.1219063
146Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.1170529
147Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0724214
148Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0473619
149Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0282179
150Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512-0.0244655
151Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0150180
152Renin-angiotensin system_Homo sapiens_hsa04614-0.0104524

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