PDIK1L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of sister chromatid cohesion (GO:0007063)7.03970753
2auditory behavior (GO:0031223)5.81323921
3translesion synthesis (GO:0019985)5.71105223
4mechanosensory behavior (GO:0007638)4.82889643
5cell morphogenesis involved in neuron differentiation (GO:0048667)4.66933364
6attachment of spindle microtubules to kinetochore (GO:0008608)4.58745172
7nucleobase catabolic process (GO:0046113)4.39453832
8ribosomal small subunit assembly (GO:0000028)4.37760627
9regulation of DNA endoreduplication (GO:0032875)4.37063648
10histone H2A acetylation (GO:0043968)4.33047740
11mitotic sister chromatid cohesion (GO:0007064)4.32786152
12startle response (GO:0001964)4.24341698
13sister chromatid segregation (GO:0000819)4.19852920
14DNA topological change (GO:0006265)4.07900128
15postreplication repair (GO:0006301)4.02607071
16neural tube formation (GO:0001841)4.01781319
17synapsis (GO:0007129)3.96171287
18protein localization to kinetochore (GO:0034501)3.95219847
19DNA unwinding involved in DNA replication (GO:0006268)3.79978518
20DNA double-strand break processing (GO:0000729)3.79872302
21nucleotide-excision repair, DNA gap filling (GO:0006297)3.68909006
22mitotic chromosome condensation (GO:0007076)3.63209526
23mitotic sister chromatid segregation (GO:0000070)3.59070848
24histone mRNA catabolic process (GO:0071044)3.56902562
25positive regulation of mitochondrial fission (GO:0090141)3.56138211
26polyketide metabolic process (GO:0030638)3.55215350
27doxorubicin metabolic process (GO:0044598)3.55215350
28daunorubicin metabolic process (GO:0044597)3.55215350
29dosage compensation (GO:0007549)3.52644444
30kinetochore organization (GO:0051383)3.50122263
31innervation (GO:0060384)3.50025827
32negative regulation of cell cycle G2/M phase transition (GO:1902750)3.49712118
33definitive hemopoiesis (GO:0060216)3.47052660
34histone H2A monoubiquitination (GO:0035518)3.44402019
35protein localization to chromosome, centromeric region (GO:0071459)3.44097408
36DNA-dependent DNA replication (GO:0006261)3.43427246
37negative regulation of DNA recombination (GO:0045910)3.41184336
38cullin deneddylation (GO:0010388)3.40292412
39ribonucleoprotein complex disassembly (GO:0032988)3.39107450
40pyrimidine nucleobase catabolic process (GO:0006208)3.37889461
41mitotic recombination (GO:0006312)3.37511369
42regulation of chromosome segregation (GO:0051983)3.35856123
43neuron cell-cell adhesion (GO:0007158)3.35736043
44response to auditory stimulus (GO:0010996)3.33754412
45telomere maintenance via semi-conservative replication (GO:0032201)3.33218359
46meiotic chromosome segregation (GO:0045132)3.30916374
47interkinetic nuclear migration (GO:0022027)3.28985971
48presynaptic membrane assembly (GO:0097105)3.28512222
49positive regulation of histone H3-K4 methylation (GO:0051571)3.27224139
50spermatid nucleus differentiation (GO:0007289)3.26614617
51CENP-A containing nucleosome assembly (GO:0034080)3.21891937
52histone mRNA metabolic process (GO:0008334)3.21688058
53nuclear pore complex assembly (GO:0051292)3.20651550
54gamma-aminobutyric acid transport (GO:0015812)3.20503400
55DNA replication-independent nucleosome assembly (GO:0006336)3.17550595
56DNA replication-independent nucleosome organization (GO:0034724)3.17550595
57microtubule polymerization or depolymerization (GO:0031109)3.15961271
58negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.15766308
59negative regulation of sister chromatid segregation (GO:0033046)3.15766308
60negative regulation of mitotic sister chromatid separation (GO:2000816)3.15766308
61negative regulation of mitotic sister chromatid segregation (GO:0033048)3.15766308
62regulation of double-strand break repair via homologous recombination (GO:0010569)3.15411425
63sister chromatid cohesion (GO:0007062)3.14380982
64telomere maintenance via recombination (GO:0000722)3.13686932
65spindle checkpoint (GO:0031577)3.13569439
66centriole replication (GO:0007099)3.13384148
67interferon-gamma production (GO:0032609)3.13204099
68organelle disassembly (GO:1903008)3.12933064
69heparin metabolic process (GO:0030202)3.12878308
70heparin biosynthetic process (GO:0030210)3.12878308
71resolution of meiotic recombination intermediates (GO:0000712)3.12446098
72piRNA metabolic process (GO:0034587)3.12369844
73spindle assembly checkpoint (GO:0071173)3.11317949
74microtubule anchoring (GO:0034453)3.10282476
75negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.09147946
76protein localization to cilium (GO:0061512)3.08929263
77succinate metabolic process (GO:0006105)3.08220285
78intraciliary transport (GO:0042073)3.07685961
79negative regulation of chromosome segregation (GO:0051985)3.05836545
80establishment of mitochondrion localization (GO:0051654)3.05490453
81DNA strand elongation involved in DNA replication (GO:0006271)3.05043291
82nuclear pore organization (GO:0006999)3.03912912
83chromatin remodeling at centromere (GO:0031055)3.03818639
84negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.03145479
85regulation of sister chromatid segregation (GO:0033045)3.01293357
86regulation of mitotic sister chromatid separation (GO:0010965)3.01293357
87regulation of mitotic sister chromatid segregation (GO:0033047)3.01293357
88epithelial cell differentiation involved in prostate gland development (GO:0060742)3.00833594
89protein deneddylation (GO:0000338)3.00248382
90regulation of RNA export from nucleus (GO:0046831)2.99142622
91mitotic spindle assembly checkpoint (GO:0007094)2.98433353
92regulation of mitotic metaphase/anaphase transition (GO:0030071)2.98169791
93DNA strand elongation (GO:0022616)2.96984737
94base-excision repair, AP site formation (GO:0006285)2.96910310
95regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.93455523
96chromosome segregation (GO:0007059)2.93328991
97ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.92803010
98negative regulation of RNA splicing (GO:0033119)2.91470846
99presynaptic membrane organization (GO:0097090)2.90847508
100DNA catabolic process, exonucleolytic (GO:0000738)2.89637938
101protein localization to chromosome (GO:0034502)2.88710053
102peroxisome fission (GO:0016559)2.88115463
103microtubule depolymerization (GO:0007019)2.86081420
104RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.85974801
105DNA methylation involved in gamete generation (GO:0043046)2.85932992
106positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.85721382
107regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.85255974
108negative regulation of histone methylation (GO:0031061)2.84591766
109positive regulation of mitotic sister chromatid separation (GO:1901970)2.83866137
110positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.83866137
111positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.83866137
112mitotic spindle organization (GO:0007052)2.83319873
113granulocyte differentiation (GO:0030851)2.82778781
114cell wall macromolecule catabolic process (GO:0016998)2.81902489
115regulation of meiosis I (GO:0060631)2.81784860
116DNA damage response, detection of DNA damage (GO:0042769)2.80266493
117regulation of centriole replication (GO:0046599)2.79308617
118cell wall macromolecule metabolic process (GO:0044036)2.79049303
119mitotic spindle checkpoint (GO:0071174)2.78223540
120negative regulation of DNA-dependent DNA replication (GO:2000104)2.77040796
121DNA ligation (GO:0006266)2.75099077
122cellular response to prostaglandin stimulus (GO:0071379)2.73967078
123regulation of histone H3-K4 methylation (GO:0051569)2.70778558
124antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.69059531
125antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.69059531
126positive regulation of megakaryocyte differentiation (GO:0045654)2.67909175
127neurotransmitter-gated ion channel clustering (GO:0072578)2.67836632
128histone monoubiquitination (GO:0010390)2.67635061
129hepatocyte apoptotic process (GO:0097284)2.67533860
130cochlea development (GO:0090102)2.66539979
131positive regulation of erythrocyte differentiation (GO:0045648)2.66411742
132deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.66093399
133nucleosome assembly (GO:0006334)2.65560959
134regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.65239536
135protoporphyrinogen IX biosynthetic process (GO:0006782)2.64895994
136male meiosis I (GO:0007141)2.64071775
137regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.63950690
138replication fork processing (GO:0031297)2.63143379
139DNA integration (GO:0015074)2.62625446
140protein-cofactor linkage (GO:0018065)2.62174659
141cellular response to zinc ion (GO:0071294)2.60399808
142synaptic vesicle maturation (GO:0016188)2.57322926
143protein K11-linked ubiquitination (GO:0070979)2.56997838
144protoporphyrinogen IX metabolic process (GO:0046501)2.54381436
145DNA replication-dependent nucleosome organization (GO:0034723)2.51674055
146DNA replication-dependent nucleosome assembly (GO:0006335)2.51674055
147nonmotile primary cilium assembly (GO:0035058)2.51082165
148positive regulation of cellular response to oxidative stress (GO:1900409)2.50817165
149positive regulation of response to oxidative stress (GO:1902884)2.50817165
150double-strand break repair via nonhomologous end joining (GO:0006303)2.50465070
151non-recombinational repair (GO:0000726)2.50465070
152negative regulation of meiotic cell cycle (GO:0051447)2.49625943
153male meiosis (GO:0007140)2.47700235
154positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.45478109
155glycosphingolipid biosynthetic process (GO:0006688)2.43048519
156microtubule nucleation (GO:0007020)2.39925837
157kinetochore assembly (GO:0051382)2.39358610
158meiotic cell cycle (GO:0051321)2.38716591
159maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.38542841
160chromosome organization involved in meiosis (GO:0070192)2.38259103
161peptidyl-lysine trimethylation (GO:0018023)2.37399012
162reciprocal DNA recombination (GO:0035825)2.36242115
163reciprocal meiotic recombination (GO:0007131)2.36242115
164cornea development in camera-type eye (GO:0061303)2.34238915
165protein K6-linked ubiquitination (GO:0085020)2.32559859
166response to pheromone (GO:0019236)2.32075308
167protein localization to peroxisome (GO:0072662)2.29044311
168protein targeting to peroxisome (GO:0006625)2.29044311
169establishment of protein localization to peroxisome (GO:0072663)2.29044311
170ubiquinone metabolic process (GO:0006743)2.28309164
171regulation of acyl-CoA biosynthetic process (GO:0050812)2.27611920
172negative regulation of meiosis (GO:0045835)2.27445446
173somatic diversification of immune receptors via somatic mutation (GO:0002566)2.27239755
174somatic hypermutation of immunoglobulin genes (GO:0016446)2.27239755
175positive regulation of mRNA processing (GO:0050685)2.26710174
176termination of RNA polymerase II transcription (GO:0006369)2.22779593
177nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.22362876

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.99246261
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.43832413
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.46803751
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.03429803
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.95382291
6MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.86627470
7RBPJ_22232070_ChIP-Seq_NCS_Mouse2.53632056
8E2F1_21310950_ChIP-Seq_MCF-7_Human2.39687235
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.35014328
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.33386871
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.27921520
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.19484586
13GBX2_23144817_ChIP-Seq_PC3_Human2.17946318
14NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.16441290
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.15295238
16VDR_22108803_ChIP-Seq_LS180_Human2.13689709
17EWS_26573619_Chip-Seq_HEK293_Human2.06407180
18SCL_19346495_ChIP-Seq_HPC-7_Human2.04302724
19GATA1_22025678_ChIP-Seq_K562_Human2.01681523
20E2F7_22180533_ChIP-Seq_HELA_Human10.1312593
21KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.96805969
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.94492614
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.93036824
24SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.89781198
25VDR_23849224_ChIP-Seq_CD4+_Human1.85979096
26FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.84049645
27ER_23166858_ChIP-Seq_MCF-7_Human1.83246581
28AR_21909140_ChIP-Seq_LNCAP_Human1.82008954
29STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.80583915
30EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.76895235
31MYC_18555785_ChIP-Seq_MESCs_Mouse1.72670054
32CIITA_25753668_ChIP-Seq_RAJI_Human1.72521103
33ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.71932875
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71836922
35BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.71497315
36* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.68086783
37FOXP3_21729870_ChIP-Seq_TREG_Human1.66220786
38HOXB4_20404135_ChIP-ChIP_EML_Mouse1.66036905
39MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.65534765
40ESR1_15608294_ChIP-ChIP_MCF-7_Human1.65340884
41RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.64160190
42KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.62284991
43PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.62078771
44STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.62009298
45YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.61432571
46SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.59850833
47ERG_20887958_ChIP-Seq_HPC-7_Mouse1.58920427
48POU3F2_20337985_ChIP-ChIP_501MEL_Human1.53482167
49MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.52483635
50HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.51603152
51TP63_19390658_ChIP-ChIP_HaCaT_Human1.51308461
52SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.50684116
53GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.49172001
54ELK1_19687146_ChIP-ChIP_HELA_Human1.47699996
55MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.47209062
56CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.45543122
57AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.44497178
58MYC_22102868_ChIP-Seq_BL_Human1.43928245
59TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43805204
60SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.43604077
61ETS1_20019798_ChIP-Seq_JURKAT_Human1.43022874
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42591624
63CBP_20019798_ChIP-Seq_JUKART_Human1.42591624
64PKCTHETA_26484144_Chip-Seq_BREAST_Human1.39145133
65FUS_26573619_Chip-Seq_HEK293_Human1.38956597
66* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.38639274
67SMAD4_21799915_ChIP-Seq_A2780_Human1.37566437
68NELFA_20434984_ChIP-Seq_ESCs_Mouse1.36602821
69MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.36183279
70EST1_17652178_ChIP-ChIP_JURKAT_Human1.36058910
71FLI1_27457419_Chip-Seq_LIVER_Mouse1.35929772
72OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34631360
73MYC_18940864_ChIP-ChIP_HL60_Human1.31917133
74* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.31859494
75PIAS1_25552417_ChIP-Seq_VCAP_Human1.29410149
76CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.29399051
77UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.28375186
78GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27576882
79CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.27534852
80RNF2_27304074_Chip-Seq_NSC_Mouse1.27412899
81STAT3_23295773_ChIP-Seq_U87_Human1.22416959
82TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22081705
83NOTCH1_21737748_ChIP-Seq_TLL_Human1.21321606
84TP53_22573176_ChIP-Seq_HFKS_Human1.21074462
85TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.19482783
86ZFP57_27257070_Chip-Seq_ESCs_Mouse1.19393573
87HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.19232254
88SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.18789046
89GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.18285036
90POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.17888862
91SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.17884572
92IRF8_22096565_ChIP-ChIP_GC-B_Human1.15891527
93RUNX_20019798_ChIP-Seq_JUKART_Human1.15785474
94VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.15760889
95TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14737568
96P300_19829295_ChIP-Seq_ESCs_Human1.13600054
97JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.12959752
98KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12862255
99MYC_19030024_ChIP-ChIP_MESCs_Mouse1.12230648
100IRF1_19129219_ChIP-ChIP_H3396_Human1.12189529
101NANOG_18555785_Chip-Seq_ESCs_Mouse1.12092735
102ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.10926630
103* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.10632885
104DCP1A_22483619_ChIP-Seq_HELA_Human1.09971021
105AR_25329375_ChIP-Seq_VCAP_Human1.09569135
106MYB_26560356_Chip-Seq_TH2_Human1.08051385
107EZH2_22144423_ChIP-Seq_EOC_Human1.07276599
108* KDM5A_27292631_Chip-Seq_BREAST_Human1.07235513
109PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.07043514
110TCF4_23295773_ChIP-Seq_U87_Human1.06081590
111SPI1_23547873_ChIP-Seq_NB4_Human1.04401450
112GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02654716
113EZH2_27294783_Chip-Seq_NPCs_Mouse1.01783162
114XRN2_22483619_ChIP-Seq_HELA_Human1.01700796
115SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01263934
116EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01194650
117CTBP2_25329375_ChIP-Seq_LNCAP_Human0.99762489
118TAF15_26573619_Chip-Seq_HEK293_Human0.99633645
119P53_22387025_ChIP-Seq_ESCs_Mouse0.98342583
120PCGF2_27294783_Chip-Seq_ESCs_Mouse0.97638333
121GABP_17652178_ChIP-ChIP_JURKAT_Human0.97105221
122STAT4_19710469_ChIP-ChIP_TH1__Mouse0.96981613
123CBX2_27304074_Chip-Seq_ESCs_Mouse0.96933747
124SRF_21415370_ChIP-Seq_HL-1_Mouse0.96779732
125* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.96643813
126SMAD3_21741376_ChIP-Seq_EPCs_Human0.96367687
127FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.95203821
128SUZ12_18555785_Chip-Seq_ESCs_Mouse0.95015573
129SOX2_18555785_ChIP-Seq_MESCs_Mouse0.94131728
130PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.94095180
131ZNF274_21170338_ChIP-Seq_K562_Hela0.93001762
132SMAD_19615063_ChIP-ChIP_OVARY_Human0.92918880
133ZFX_18555785_ChIP-Seq_MESCs_Mouse0.92730209
134JUN_21703547_ChIP-Seq_K562_Human0.91993434
135E2F1_18555785_Chip-Seq_ESCs_Mouse0.91874732
136MYB_26560356_Chip-Seq_TH1_Human0.91825798
137RUNX2_22187159_ChIP-Seq_PCA_Human0.91522866
138MYCN_18555785_ChIP-Seq_MESCs_Mouse0.90603642
139FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.89237403
140IGF1R_20145208_ChIP-Seq_DFB_Human0.89237395
141TAL1_26923725_Chip-Seq_HPCs_Mouse0.87834241
142POU5F1_16153702_ChIP-ChIP_HESCs_Human0.83635853
143CTBP1_25329375_ChIP-Seq_LNCAP_Human0.83467701
144* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.82417368
145UTX_26944678_Chip-Seq_JUKART_Human0.81582236
146THAP11_20581084_ChIP-Seq_MESCs_Mouse0.81147170
147MYB_21317192_ChIP-Seq_ERMYB_Mouse0.80955217
148CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.80909467
149VDR_21846776_ChIP-Seq_THP-1_Human0.80223122
150CREB1_15753290_ChIP-ChIP_HEK293T_Human0.79792072
151GABP_19822575_ChIP-Seq_HepG2_Human0.79616251
152* TTF2_22483619_ChIP-Seq_HELA_Human0.79612452

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle3.84590894
2MP0006054_spinal_hemorrhage3.78237250
3MP0000569_abnormal_digit_pigmentation3.38812348
4MP0010094_abnormal_chromosome_stability2.80183121
5MP0002822_catalepsy2.67731824
6MP0003890_abnormal_embryonic-extraembry2.66022878
7MP0001529_abnormal_vocalization2.64752600
8MP0003121_genomic_imprinting2.61531105
9MP0002736_abnormal_nociception_after2.47763485
10MP0009379_abnormal_foot_pigmentation2.32530171
11MP0008789_abnormal_olfactory_epithelium2.30828326
12MP0004147_increased_porphyrin_level2.30702804
13MP0003880_abnormal_central_pattern2.19436600
14MP0008057_abnormal_DNA_replication2.12981829
15MP0002396_abnormal_hematopoietic_system2.08966980
16MP0003111_abnormal_nucleus_morphology2.05400997
17MP0003787_abnormal_imprinting2.02113151
18MP0006276_abnormal_autonomic_nervous2.00641039
19MP0003077_abnormal_cell_cycle2.00081496
20MP0005499_abnormal_olfactory_system1.96984758
21MP0005394_taste/olfaction_phenotype1.96984758
22MP0008995_early_reproductive_senescence1.95664125
23MP0005248_abnormal_Harderian_gland1.83119821
24MP0004859_abnormal_synaptic_plasticity1.82282648
25MP0005220_abnormal_exocrine_pancreas1.78599498
26MP0004270_analgesia1.76158662
27MP0003221_abnormal_cardiomyocyte_apopto1.75552526
28MP0005174_abnormal_tail_pigmentation1.72593019
29MP0000490_abnormal_crypts_of1.72535372
30MP0002095_abnormal_skin_pigmentation1.70887380
31MP0000015_abnormal_ear_pigmentation1.68928881
32MP0004381_abnormal_hair_follicle1.67187071
33MP0000465_gastrointestinal_hemorrhage1.64824373
34MP0005075_abnormal_melanosome_morpholog1.64270194
35MP0004808_abnormal_hematopoietic_stem1.60427715
36MP0009046_muscle_twitch1.59147672
37MP0001188_hyperpigmentation1.58233453
38MP0002166_altered_tumor_susceptibility1.57444219
39MP0001986_abnormal_taste_sensitivity1.56241010
40MP0003718_maternal_effect1.55259412
41MP0009745_abnormal_behavioral_response1.54260475
42MP0006035_abnormal_mitochondrial_morpho1.53310048
43MP0000372_irregular_coat_pigmentation1.47911239
44MP0005386_behavior/neurological_phenoty1.47479482
45MP0004924_abnormal_behavior1.47479482
46MP0003786_premature_aging1.46923371
47MP0009780_abnormal_chondrocyte_physiolo1.46908320
48MP0003693_abnormal_embryo_hatching1.46280321
49MP0005423_abnormal_somatic_nervous1.46168354
50MP0008058_abnormal_DNA_repair1.42885539
51MP0005187_abnormal_penis_morphology1.41918637
52MP0005671_abnormal_response_to1.41533045
53MP0003635_abnormal_synaptic_transmissio1.41256754
54MP0001929_abnormal_gametogenesis1.40865234
55MP0003763_abnormal_thymus_physiology1.40094132
56MP0001984_abnormal_olfaction1.38970838
57MP0002063_abnormal_learning/memory/cond1.38894097
58MP0002398_abnormal_bone_marrow1.37011908
59MP0004957_abnormal_blastocyst_morpholog1.36638277
60MP0003436_decreased_susceptibility_to1.34687892
61MP0002234_abnormal_pharynx_morphology1.34586392
62MP0002837_dystrophic_cardiac_calcinosis1.34091327
63MP0003943_abnormal_hepatobiliary_system1.33705612
64MP0004811_abnormal_neuron_physiology1.32704914
65MP0002210_abnormal_sex_determination1.30174096
66MP0001835_abnormal_antigen_presentation1.29264559
67MP0003183_abnormal_peptide_metabolism1.29056621
68MP0008877_abnormal_DNA_methylation1.28570729
69MP0002102_abnormal_ear_morphology1.28253556
70MP0002272_abnormal_nervous_system1.28198378
71MP0001968_abnormal_touch/_nociception1.26221889
72MP0001764_abnormal_homeostasis1.22429855
73MP0002638_abnormal_pupillary_reflex1.22056221
74MP0008961_abnormal_basal_metabolism1.21883770
75MP0002006_tumorigenesis1.20893843
76MP0003698_abnormal_male_reproductive1.20879411
77MP0001915_intracranial_hemorrhage1.18700615
78MP0005365_abnormal_bile_salt1.18103365
79MP0005367_renal/urinary_system_phenotyp1.16244824
80MP0000516_abnormal_urinary_system1.16244824
81MP0001545_abnormal_hematopoietic_system1.15601883
82MP0005397_hematopoietic_system_phenotyp1.15601883
83MP0001800_abnormal_humoral_immune1.15081122
84MP0002572_abnormal_emotion/affect_behav1.14702768
85MP0001486_abnormal_startle_reflex1.14250951
86MP0003567_abnormal_fetal_cardiomyocyte1.14014786
87MP0002064_seizures1.12079306
88MP0004142_abnormal_muscle_tone1.11272017
89MP0010352_gastrointestinal_tract_polyps1.10583252
90MP0001145_abnormal_male_reproductive1.10293302
91MP0003866_abnormal_defecation1.09953238
92MP0000537_abnormal_urethra_morphology1.09503981
93MP0000631_abnormal_neuroendocrine_gland1.08267794
94MP0006036_abnormal_mitochondrial_physio1.08115912
95MP0000653_abnormal_sex_gland1.08105859
96MP0000703_abnormal_thymus_morphology1.07954875
97MP0002734_abnormal_mechanical_nocicepti1.05495403
98MP0002693_abnormal_pancreas_physiology1.04563395
99MP0005646_abnormal_pituitary_gland1.03353326
100MP0003122_maternal_imprinting1.01176580
101MP0000716_abnormal_immune_system1.00836028
102MP0001502_abnormal_circadian_rhythm1.00466339
103MP0005076_abnormal_cell_differentiation1.00223406
104MP0005551_abnormal_eye_electrophysiolog1.00095139
105MP0005409_darkened_coat_color0.99744284
106MP0000427_abnormal_hair_cycle0.98974331
107MP0002722_abnormal_immune_system0.98215845
108MP0006292_abnormal_olfactory_placode0.98023246
109MP0002420_abnormal_adaptive_immunity0.97162752
110MP0001849_ear_inflammation0.96942568
111MP0000566_synostosis0.96182022
112MP0009697_abnormal_copulation0.95088249
113MP0000955_abnormal_spinal_cord0.92873660
114MP0002429_abnormal_blood_cell0.91434753
115MP0002557_abnormal_social/conspecific_i0.91226091
116MP0001819_abnormal_immune_cell0.91215195
117MP0002882_abnormal_neuron_morphology0.90985126
118MP0002909_abnormal_adrenal_gland0.90752800
119MP0000689_abnormal_spleen_morphology0.90525093
120MP0004885_abnormal_endolymph0.90523539
121MP0002928_abnormal_bile_duct0.90281112
122MP0001501_abnormal_sleep_pattern0.90210089
123MP0002019_abnormal_tumor_incidence0.88234583
124MP0001346_abnormal_lacrimal_gland0.88061293
125MP0002067_abnormal_sensory_capabilities0.86863640
126MP0008007_abnormal_cellular_replicative0.86067835
127MP0006072_abnormal_retinal_apoptosis0.85206098
128MP0003300_gastrointestinal_ulcer0.84604956
129MP0005000_abnormal_immune_tolerance0.84405581
130MP0000778_abnormal_nervous_system0.83868112
131MP0002160_abnormal_reproductive_system0.83844169
132MP0002233_abnormal_nose_morphology0.83548449
133MP0001944_abnormal_pancreas_morphology0.82925768
134MP0003303_peritoneal_inflammation0.80821841
135MP0002184_abnormal_innervation0.80513404
136MP0002452_abnormal_antigen_presenting0.78933865
137MP0005025_abnormal_response_to0.78423178
138MP0002009_preneoplasia0.77964465
139MP0001919_abnormal_reproductive_system0.77835621
140MP0005389_reproductive_system_phenotype0.77678926
141MP0003656_abnormal_erythrocyte_physiolo0.77194730
142MP0002152_abnormal_brain_morphology0.76970152
143MP0005266_abnormal_metabolism0.76757653
144MP0000358_abnormal_cell_content/0.76742106
145MP0004215_abnormal_myocardial_fiber0.76694820
146MP0001970_abnormal_pain_threshold0.76214951
147MP0001177_atelectasis0.75724529
148MP0003861_abnormal_nervous_system0.75566013
149MP0005645_abnormal_hypothalamus_physiol0.74918731
150MP0010678_abnormal_skin_adnexa0.74848506
151MP0004264_abnormal_extraembryonic_tissu0.74466962
152MP0005253_abnormal_eye_physiology0.72865249
153MP0008875_abnormal_xenobiotic_pharmacok0.72437656
154MP0002751_abnormal_autonomic_nervous0.71713508
155MP0002733_abnormal_thermal_nociception0.71685671
156MP0000350_abnormal_cell_proliferation0.70906913
157MP0005084_abnormal_gallbladder_morpholo0.70230344
158MP0005464_abnormal_platelet_physiology0.69440295
159MP0002139_abnormal_hepatobiliary_system0.66618554
160MP0002735_abnormal_chemical_nociception0.65579481
161MP0002723_abnormal_immune_serum0.63835999

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)5.62860821
2Subacute progressive viral hepatitis (HP:0006572)3.61320049
3Reticulocytopenia (HP:0001896)3.49167683
4Increased nuchal translucency (HP:0010880)3.42162125
5Papilledema (HP:0001085)3.37745266
6Medial flaring of the eyebrow (HP:0010747)3.32062331
7Abnormality of chromosome stability (HP:0003220)3.30181790
8Congenital primary aphakia (HP:0007707)3.20574629
9Abnormality of the fingertips (HP:0001211)3.10845561
10Chromsome breakage (HP:0040012)2.95917289
11Amyotrophic lateral sclerosis (HP:0007354)2.84336643
12Cortical dysplasia (HP:0002539)2.81049581
13Chromosomal breakage induced by crosslinking agents (HP:0003221)2.78874706
14Drooling (HP:0002307)2.78592931
15Aplasia/Hypoplasia of the uvula (HP:0010293)2.78420937
16Hyperventilation (HP:0002883)2.77938039
17IgM deficiency (HP:0002850)2.72227720
18Split foot (HP:0001839)2.70043053
19Abnormality of the preputium (HP:0100587)2.69609344
20Hypoplasia of the thymus (HP:0000778)2.64932487
21Degeneration of the lateral corticospinal tracts (HP:0002314)2.64195158
22Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.64195158
23Meckel diverticulum (HP:0002245)2.61701161
24Viral hepatitis (HP:0006562)2.60976271
25Myelodysplasia (HP:0002863)2.58585263
26Excessive salivation (HP:0003781)2.57089486
27Poor coordination (HP:0002370)2.56937092
28Long clavicles (HP:0000890)2.54360224
29Abnormality of the ileum (HP:0001549)2.52729531
30Thyroid carcinoma (HP:0002890)2.51764027
31Aplasia/Hypoplasia of the sacrum (HP:0008517)2.50794777
32Hepatitis (HP:0012115)2.49247975
33Hypothermia (HP:0002045)2.48470543
34Progressive inability to walk (HP:0002505)2.47742220
35Abnormality of the carotid arteries (HP:0005344)2.47542363
36Fair hair (HP:0002286)2.43345841
37Cutis marmorata (HP:0000965)2.42485782
38Recurrent bronchitis (HP:0002837)2.38911259
39IgG deficiency (HP:0004315)2.36777680
40Small intestinal stenosis (HP:0012848)2.36079990
41Duodenal stenosis (HP:0100867)2.36079990
42Abnormality of the corticospinal tract (HP:0002492)2.35841076
43Shoulder girdle muscle weakness (HP:0003547)2.35701349
44Nephroblastoma (Wilms tumor) (HP:0002667)2.35187115
45Genital tract atresia (HP:0001827)2.35173191
46Obsessive-compulsive behavior (HP:0000722)2.35119445
47Clubbing of toes (HP:0100760)2.34661027
48Abnormal hair whorl (HP:0010721)2.34303726
49Oligodactyly (hands) (HP:0001180)2.33844268
50Abnormality of abdominal situs (HP:0011620)2.33135337
51Abdominal situs inversus (HP:0003363)2.33135337
52Aplasia/Hypoplasia of the nipples (HP:0006709)2.30840816
53Urinary urgency (HP:0000012)2.30538228
54Vaginal atresia (HP:0000148)2.29477139
55Severe Myopia (HP:0011003)2.29022874
56Absent thumb (HP:0009777)2.27864029
57Intestinal atresia (HP:0011100)2.27495688
58Atrophy/Degeneration involving motor neurons (HP:0007373)2.27013290
59Rimmed vacuoles (HP:0003805)2.26841475
60Lissencephaly (HP:0001339)2.17929903
61Nephronophthisis (HP:0000090)2.17273999
62Specific learning disability (HP:0001328)2.17063559
63Birth length less than 3rd percentile (HP:0003561)2.16186389
64Protruding tongue (HP:0010808)2.15783084
6511 pairs of ribs (HP:0000878)2.15610232
66Inability to walk (HP:0002540)2.15470306
67Hypochromic microcytic anemia (HP:0004840)2.14792024
68Febrile seizures (HP:0002373)2.14151091
69Thyroid-stimulating hormone excess (HP:0002925)2.13780288
70Dyskinesia (HP:0100660)2.11519498
71Truncal obesity (HP:0001956)2.10390750
72Embryonal neoplasm (HP:0002898)2.10035369
73Abnormal lung lobation (HP:0002101)2.09899325
74Medulloblastoma (HP:0002885)2.09129050
75Chronic otitis media (HP:0000389)2.08864743
76Hyperacusis (HP:0010780)2.08417020
77Embryonal renal neoplasm (HP:0011794)2.08075201
78Myositis (HP:0100614)2.07204687
79Mutism (HP:0002300)2.05925874
80Abnormality of midbrain morphology (HP:0002418)2.03690368
81Molar tooth sign on MRI (HP:0002419)2.03690368
82Skull defect (HP:0001362)2.03523838
83Thrombocytosis (HP:0001894)2.02832385
84Aplasia/Hypoplasia of the sternum (HP:0006714)2.02795786
85Focal motor seizures (HP:0011153)2.02425881
86Absent speech (HP:0001344)2.01398610
87Generalized hypopigmentation of hair (HP:0011358)2.00097851
88Horizontal nystagmus (HP:0000666)1.99696691
89Recurrent gram-negative bacterial infections (HP:0005420)1.99063338
90Retinal dysplasia (HP:0007973)1.98160152
91Postaxial hand polydactyly (HP:0001162)1.97996079
92Breast carcinoma (HP:0003002)1.97914589
93Ankle clonus (HP:0011448)1.97357222
94Methylmalonic acidemia (HP:0002912)1.96972329
95Chronic hepatic failure (HP:0100626)1.92463176
96Gait imbalance (HP:0002141)1.92389206
97Panhypogammaglobulinemia (HP:0003139)1.92211573
98Hepatocellular carcinoma (HP:0001402)1.91993630
99Toxemia of pregnancy (HP:0100603)1.91777104
100Renovascular hypertension (HP:0100817)1.91723304
101Broad-based gait (HP:0002136)1.91675909
102Gonadotropin excess (HP:0000837)1.91174548
103Abnormality of the heme biosynthetic pathway (HP:0010472)1.91172168
104Sloping forehead (HP:0000340)1.90587243
105Aqueductal stenosis (HP:0002410)1.90442037
106Transitional cell carcinoma of the bladder (HP:0006740)1.89796180
107Pancreatic fibrosis (HP:0100732)1.89778958
108Colon cancer (HP:0003003)1.89429907
109Germ cell neoplasia (HP:0100728)1.88753746
110Pachygyria (HP:0001302)1.88532603
111Limb hypertonia (HP:0002509)1.88431766
112Absent rod-and cone-mediated responses on ERG (HP:0007688)1.88347266
113Elfin facies (HP:0004428)1.88133640
114Decreased testicular size (HP:0008734)1.88020881
115Aplastic anemia (HP:0001915)1.86728269
116Abnormality of the columella (HP:0009929)1.86306111
117Retrobulbar optic neuritis (HP:0100654)1.86129298
118Optic neuritis (HP:0100653)1.86129298
119Epileptic encephalopathy (HP:0200134)1.86060724
120Chronic sinusitis (HP:0011109)1.85987343
121True hermaphroditism (HP:0010459)1.84746424
122Abnormality of the duodenum (HP:0002246)1.83380318
123Pancreatic cysts (HP:0001737)1.81491684
124Astigmatism (HP:0000483)1.81310460
125Thyroiditis (HP:0100646)1.81104120
126Abnormality of DNA repair (HP:0003254)1.80739897
127B lymphocytopenia (HP:0010976)1.79816973
128Abnormality of B cell number (HP:0010975)1.79816973
129High anterior hairline (HP:0009890)1.79314695
130Abnormality of the hip-girdle musculature (HP:0001445)1.79165888
131Abnormality of the musculature of the pelvis (HP:0001469)1.79165888
132Delusions (HP:0000746)1.79078815
133Micronodular cirrhosis (HP:0001413)1.78998443
134Hypsarrhythmia (HP:0002521)1.78643507
135Encephalitis (HP:0002383)1.78573851
136Low anterior hairline (HP:0000294)1.78475941
137Generalized myoclonic seizures (HP:0002123)1.77797144
138Lower limb muscle weakness (HP:0007340)1.77407350
139Generalized tonic-clonic seizures (HP:0002069)1.76997034
140Prominent nose (HP:0000448)1.76595587
141Abnormality of the renal medulla (HP:0100957)1.76056948
142Abnormality of the labia minora (HP:0012880)1.74952939
143Broad foot (HP:0001769)1.74653274
144Intestinal polyposis (HP:0200008)1.74227803
145Meningitis (HP:0001287)1.74086208
146Uterine leiomyosarcoma (HP:0002891)1.73807105
147Leiomyosarcoma (HP:0100243)1.73807105
148Oligodactyly (HP:0012165)1.73485646
149IgA deficiency (HP:0002720)1.71776384
150Keratoconjunctivitis sicca (HP:0001097)1.70665244
151Agammaglobulinemia (HP:0004432)1.70568289
152Renal cortical cysts (HP:0000803)1.70469858
153Impaired vibration sensation in the lower limbs (HP:0002166)1.68594176
154Bone marrow hypocellularity (HP:0005528)1.68402237
155Aplasia/Hypoplasia of the tibia (HP:0005772)1.68083615
156Spastic diplegia (HP:0001264)1.68069660
157Spastic gait (HP:0002064)1.67933728
158Postaxial foot polydactyly (HP:0001830)1.67847166
159Astrocytoma (HP:0009592)1.66796975
160Abnormality of the astrocytes (HP:0100707)1.66796975
161Short tibia (HP:0005736)1.66733576
162Preaxial hand polydactyly (HP:0001177)1.66005821
163EEG with generalized epileptiform discharges (HP:0011198)1.65908621
164Cone-rod dystrophy (HP:0000548)1.65612855
165Papillary thyroid carcinoma (HP:0002895)1.64825647
166Brushfield spots (HP:0001088)1.64784311
167Nephrogenic diabetes insipidus (HP:0009806)1.64633854
168Abnormality of the prostate (HP:0008775)1.64373704
169Morphological abnormality of the pyramidal tract (HP:0002062)1.63879459
170Abnormality of the lower motor neuron (HP:0002366)1.63850838

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NEK14.43256557
2NTRK23.65086614
3BCR3.46261007
4SRPK13.15127950
5FRK3.12888461
6TRIM282.88299779
7MARK12.69108676
8MAP4K22.37698601
9ERBB32.23873838
10MAP3K122.14162301
11NUAK12.05949784
12MAPK132.03685088
13STK38L1.98518611
14NEK21.95590311
15CCNB11.90858872
16PLK21.90677322
17STK161.90499661
18CDC71.87774908
19VRK11.85968297
20WNK31.80857803
21TXK1.76334173
22CDK61.73573252
23CSNK1G31.65782685
24RPS6KA41.60219157
25BMPR21.54842196
26TNIK1.52003935
27ATR1.50822874
28CSNK1A1L1.47874597
29BUB11.44401210
30CSNK1G21.29637518
31MAP2K71.26744766
32TAOK31.26473892
33EIF2AK11.25019126
34CSNK1G11.24861058
35YES11.23645512
36PASK1.23061490
37BRSK11.22679914
38PLK31.22409705
39PNCK1.20937702
40TGFBR11.20603484
41BRSK21.19156486
42MAP4K11.18639074
43BTK1.13074487
44CDK81.12781783
45LATS11.12314197
46GRK61.11034002
47WEE11.10156815
48BRD41.09561774
49JAK31.08877733
50AURKB1.08135268
51DYRK21.05501364
52CHEK21.04747171
53CDK191.01832746
54BCKDK1.01176051
55UHMK10.98930110
56TTK0.98321528
57BMPR1B0.98126189
58SCYL20.95135644
59STK100.94699272
60INSRR0.93655021
61DYRK30.93570315
62ATM0.90940137
63MKNK10.88639138
64KIT0.87839057
65KSR10.87044686
66SGK20.86245075
67FGFR30.85630657
68SYK0.85282953
69CDK40.85190544
70TEC0.84570283
71PLK10.84340711
72SIK30.82330847
73PAK40.81338006
74PTK60.81190151
75RPS6KB10.80792999
76TSSK60.80397380
77PIK3CA0.79658081
78RAF10.76447472
79OXSR10.76364147
80CLK10.72062735
81CSF1R0.69800567
82PAK30.69570181
83CHUK0.68909447
84ACVR1B0.68379445
85CDK70.67688599
86ZAK0.66850867
87CASK0.66039406
88EIF2AK20.64177114
89PINK10.63838053
90RPS6KA50.63266778
91MKNK20.63197032
92EIF2AK30.62479036
93PRKCE0.62150287
94MAP2K40.61835635
95HIPK20.58462120
96FGFR20.58214264
97DAPK10.57432288
98MAP3K40.54255435
99PKN10.52843172
100EPHA30.51641035
101RPS6KL10.50299862
102RPS6KC10.50299862
103MET0.49875141
104SIK20.49631092
105SGK30.49381978
106PRKCG0.48965920
107CHEK10.48798972
108STK40.48242403
109MINK10.47561420
110MST40.47459973
111FLT30.47167175
112TLK10.46647533
113RPS6KB20.46534346
114CDK50.46322504
115PIM10.46154038
116RPS6KA20.44917091
117DYRK1A0.44348011
118CDK30.43951791
119CAMK2A0.43885653
120RPS6KA60.43598828
121EGFR0.43174784
122STK390.42924617
123PLK40.42752781
124CDK140.42435985
125CSNK1D0.42364227
126CAMK2B0.41713999
127TAF10.41668642
128CAMK40.40361931
129CDK10.39744627
130MELK0.39135253
131LYN0.38991046
132CDK20.38520806
133STK30.37503905
134PRKACB0.37375808
135CDK180.37243389
136STK110.37034837
137CSNK1E0.34946623
138ITK0.34766464
139EEF2K0.34217150
140MAPK40.33973170
141FER0.33347011
142LCK0.32684367
143CAMKK20.31626783
144NTRK30.31446620
145MAP3K50.30837275
146FGFR40.30653185

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.66970643
2Mismatch repair_Homo sapiens_hsa034303.75784215
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.59055685
4Fanconi anemia pathway_Homo sapiens_hsa034603.55553515
5Base excision repair_Homo sapiens_hsa034103.19759696
6Non-homologous end-joining_Homo sapiens_hsa034502.96651403
7Cell cycle_Homo sapiens_hsa041102.95884527
8Nicotine addiction_Homo sapiens_hsa050332.76679375
9Propanoate metabolism_Homo sapiens_hsa006402.43775007
10Primary immunodeficiency_Homo sapiens_hsa053402.43191785
11Systemic lupus erythematosus_Homo sapiens_hsa053222.39884534
12Butanoate metabolism_Homo sapiens_hsa006502.34238472
13Maturity onset diabetes of the young_Homo sapiens_hsa049502.15485475
14One carbon pool by folate_Homo sapiens_hsa006702.14461616
15Spliceosome_Homo sapiens_hsa030402.06007697
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.01016378
17Colorectal cancer_Homo sapiens_hsa052101.97664137
18Nucleotide excision repair_Homo sapiens_hsa034201.90880480
19Homologous recombination_Homo sapiens_hsa034401.88445282
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.86237439
21N-Glycan biosynthesis_Homo sapiens_hsa005101.78937924
22Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.72724050
23RNA degradation_Homo sapiens_hsa030181.69646907
24GABAergic synapse_Homo sapiens_hsa047271.68565359
25Alcoholism_Homo sapiens_hsa050341.64015109
26Drug metabolism - other enzymes_Homo sapiens_hsa009831.59579718
27Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.56701055
28Taste transduction_Homo sapiens_hsa047421.51533593
29Endometrial cancer_Homo sapiens_hsa052131.46455954
30Regulation of autophagy_Homo sapiens_hsa041401.45309772
31Circadian rhythm_Homo sapiens_hsa047101.42864010
32Viral carcinogenesis_Homo sapiens_hsa052031.40368826
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.39453342
34mRNA surveillance pathway_Homo sapiens_hsa030151.39050375
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.38835894
36Collecting duct acid secretion_Homo sapiens_hsa049661.36365316
37Peroxisome_Homo sapiens_hsa041461.35464704
38Oocyte meiosis_Homo sapiens_hsa041141.34990468
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.34513845
40Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.25886781
41Pancreatic cancer_Homo sapiens_hsa052121.23233659
42Pyrimidine metabolism_Homo sapiens_hsa002401.22923343
43Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.21228670
44Selenocompound metabolism_Homo sapiens_hsa004501.19580965
45Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.17329546
46Transcriptional misregulation in cancer_Homo sapiens_hsa052021.16568160
47Synaptic vesicle cycle_Homo sapiens_hsa047211.15542809
48Basal transcription factors_Homo sapiens_hsa030221.14472346
49Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.13796243
50Lysine degradation_Homo sapiens_hsa003101.10833458
51Ribosome_Homo sapiens_hsa030101.10119248
52Olfactory transduction_Homo sapiens_hsa047401.08098580
53RNA polymerase_Homo sapiens_hsa030201.07090919
54RNA transport_Homo sapiens_hsa030131.06250677
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.05352403
56Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.05299016
57Herpes simplex infection_Homo sapiens_hsa051681.03681224
58Sulfur metabolism_Homo sapiens_hsa009201.02427204
59Non-small cell lung cancer_Homo sapiens_hsa052231.01662033
60Thyroid cancer_Homo sapiens_hsa052161.01448010
61Pentose and glucuronate interconversions_Homo sapiens_hsa000401.01002412
62Hepatitis B_Homo sapiens_hsa051611.00782509
63Morphine addiction_Homo sapiens_hsa050321.00434720
64Proteasome_Homo sapiens_hsa030501.00424373
65Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.00216382
66Intestinal immune network for IgA production_Homo sapiens_hsa046720.99987329
67Vitamin B6 metabolism_Homo sapiens_hsa007500.94423461
68Phototransduction_Homo sapiens_hsa047440.93966661
69MicroRNAs in cancer_Homo sapiens_hsa052060.93667533
70Amphetamine addiction_Homo sapiens_hsa050310.93323655
71Glutamatergic synapse_Homo sapiens_hsa047240.92375129
72Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.90380707
73p53 signaling pathway_Homo sapiens_hsa041150.89473035
74B cell receptor signaling pathway_Homo sapiens_hsa046620.88691286
75Parkinsons disease_Homo sapiens_hsa050120.88305279
76HTLV-I infection_Homo sapiens_hsa051660.84325419
77Oxidative phosphorylation_Homo sapiens_hsa001900.84156810
78Measles_Homo sapiens_hsa051620.83887449
79Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.83652207
80Steroid biosynthesis_Homo sapiens_hsa001000.82764230
81Pyruvate metabolism_Homo sapiens_hsa006200.82538044
82Fatty acid elongation_Homo sapiens_hsa000620.77839653
83Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76425393
84Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.76014911
85Viral myocarditis_Homo sapiens_hsa054160.75268967
86Protein export_Homo sapiens_hsa030600.73579910
87Antigen processing and presentation_Homo sapiens_hsa046120.73273063
88Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.72578662
89beta-Alanine metabolism_Homo sapiens_hsa004100.71135765
90Cocaine addiction_Homo sapiens_hsa050300.70396432
91T cell receptor signaling pathway_Homo sapiens_hsa046600.70341271
92Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.69091243
93Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.68508506
94Insulin secretion_Homo sapiens_hsa049110.66500196
95Epstein-Barr virus infection_Homo sapiens_hsa051690.66073389
96Type I diabetes mellitus_Homo sapiens_hsa049400.65966817
97Ether lipid metabolism_Homo sapiens_hsa005650.62717354
98Acute myeloid leukemia_Homo sapiens_hsa052210.62490816
99Tryptophan metabolism_Homo sapiens_hsa003800.61804910
100Prostate cancer_Homo sapiens_hsa052150.60262091
101Huntingtons disease_Homo sapiens_hsa050160.60097212
102Chronic myeloid leukemia_Homo sapiens_hsa052200.59433378
103Purine metabolism_Homo sapiens_hsa002300.59391602
104Hematopoietic cell lineage_Homo sapiens_hsa046400.55917356
105Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55905385
106Small cell lung cancer_Homo sapiens_hsa052220.55103687
107Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.54217114
108Asthma_Homo sapiens_hsa053100.54040503
109Nitrogen metabolism_Homo sapiens_hsa009100.53575152
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53194259
111Caffeine metabolism_Homo sapiens_hsa002320.53133050
112Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52779240
113Dopaminergic synapse_Homo sapiens_hsa047280.52128689
114Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50891984
115Long-term depression_Homo sapiens_hsa047300.50052392
116Fatty acid metabolism_Homo sapiens_hsa012120.48765122
117Type II diabetes mellitus_Homo sapiens_hsa049300.48508178
118NF-kappa B signaling pathway_Homo sapiens_hsa040640.45941664
119FoxO signaling pathway_Homo sapiens_hsa040680.43487707
120SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42461719
121RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.41618353
122Serotonergic synapse_Homo sapiens_hsa047260.40618675
123Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.39701559
124Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.38436196
125Prolactin signaling pathway_Homo sapiens_hsa049170.37037265
126Linoleic acid metabolism_Homo sapiens_hsa005910.37024916
127Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.36729713
1282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.36612884
129Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.35980192
130Vibrio cholerae infection_Homo sapiens_hsa051100.35841806
131Metabolic pathways_Homo sapiens_hsa011000.35702752
132Carbohydrate digestion and absorption_Homo sapiens_hsa049730.34922967
133Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.33099366
134mTOR signaling pathway_Homo sapiens_hsa041500.32821266
135Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.32389283
136Cysteine and methionine metabolism_Homo sapiens_hsa002700.31239607
137ABC transporters_Homo sapiens_hsa020100.30372426
138Primary bile acid biosynthesis_Homo sapiens_hsa001200.30371626
139Melanoma_Homo sapiens_hsa052180.30239663
140TGF-beta signaling pathway_Homo sapiens_hsa043500.28936758
141Influenza A_Homo sapiens_hsa051640.28792993
142Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.28631429
143Steroid hormone biosynthesis_Homo sapiens_hsa001400.27914226
144Circadian entrainment_Homo sapiens_hsa047130.27279668
145Jak-STAT signaling pathway_Homo sapiens_hsa046300.27132598
146AMPK signaling pathway_Homo sapiens_hsa041520.25807991
147Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.25032373
148Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.24526172
149Glioma_Homo sapiens_hsa052140.24290053
150Pentose phosphate pathway_Homo sapiens_hsa000300.22203087
151Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.21707080
152Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.20906660
153Renin secretion_Homo sapiens_hsa049240.20534908
154Insulin resistance_Homo sapiens_hsa049310.18902424

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