PDHX

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The pyruvate dehydrogenase (PDH) complex is located in the mitochondrial matrix and catalyzes the conversion of pyruvate to acetyl coenzyme A. The PDH complex thereby links glycolysis to Krebs cycle. The PDH complex contains three catalytic subunits, E1, E2, and E3, two regulatory subunits, E1 kinase and E1 phosphatase, and a non-catalytic subunit, E3 binding protein (E3BP). This gene encodes the E3 binding protein subunit; also known as component X of the pyruvate dehydrogenase complex. This protein tethers E3 dimers to the E2 core of the PDH complex. Defects in this gene are a cause of pyruvate dehydrogenase deficiency which results in neurological dysfunction and lactic acidosis in infancy and early childhood. This protein is also a minor antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC eventually leads to cirrhosis and liver failure. Alternative splicing results in multiple transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tricarboxylic acid cycle (GO:0006099)6.24491432
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.82774356
3mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.66289325
4* regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.47230170
5* regulation of acyl-CoA biosynthetic process (GO:0050812)5.44994765
6ATP synthesis coupled proton transport (GO:0015986)5.30882420
7energy coupled proton transport, down electrochemical gradient (GO:0015985)5.30882420
8respiratory electron transport chain (GO:0022904)5.14721411
9electron transport chain (GO:0022900)4.97523490
10* regulation of cofactor metabolic process (GO:0051193)4.96227287
11* regulation of coenzyme metabolic process (GO:0051196)4.96227287
12NADH metabolic process (GO:0006734)4.83609004
13positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.55075711
14sarcomere organization (GO:0045214)4.16816566
15cardiac myofibril assembly (GO:0055003)4.10195593
16regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.02709359
17negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.00303615
18quinone biosynthetic process (GO:1901663)3.99052757
19ubiquinone biosynthetic process (GO:0006744)3.99052757
20* regulation of sulfur metabolic process (GO:0042762)3.96120496
21regulation of cell communication by electrical coupling (GO:0010649)3.95901709
22regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.94297489
23chaperone-mediated protein transport (GO:0072321)3.88988018
24succinate metabolic process (GO:0006105)3.87185242
25myofibril assembly (GO:0030239)3.77533461
26oxidative phosphorylation (GO:0006119)3.76879310
27ubiquinone metabolic process (GO:0006743)3.70585343
28regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.65864118
29regulation of sequestering of triglyceride (GO:0010889)3.65402028
30carnitine shuttle (GO:0006853)3.58845606
31mitochondrial respiratory chain complex I assembly (GO:0032981)3.57587792
32NADH dehydrogenase complex assembly (GO:0010257)3.57587792
33mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.57587792
34regulation of sarcomere organization (GO:0060297)3.54562524
35regulation of relaxation of muscle (GO:1901077)3.49922306
36negative regulation of protein localization to cell surface (GO:2000009)3.47670145
37actin-myosin filament sliding (GO:0033275)3.42208524
38muscle filament sliding (GO:0030049)3.42208524
39protein complex biogenesis (GO:0070271)3.39649794
40branched-chain amino acid catabolic process (GO:0009083)3.36219735
41aspartate family amino acid catabolic process (GO:0009068)3.35704576
42behavioral response to nicotine (GO:0035095)3.33585402
43cellular ketone body metabolic process (GO:0046950)3.30873241
44sarcoplasmic reticulum calcium ion transport (GO:0070296)3.28786769
45negative regulation of potassium ion transmembrane transport (GO:1901380)3.28324695
46regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.27513778
47regulation of skeletal muscle contraction (GO:0014819)3.26351428
48fatty acid transmembrane transport (GO:1902001)3.24519115
49cardiac muscle contraction (GO:0060048)3.22854646
50inner mitochondrial membrane organization (GO:0007007)3.18443502
51mitochondrial respiratory chain complex assembly (GO:0033108)3.18144819
52ATP biosynthetic process (GO:0006754)3.17295871
53regulation of actin filament-based movement (GO:1903115)3.15326884
54cardiac muscle cell development (GO:0055013)3.15073970
55aerobic respiration (GO:0009060)3.13123755
56cardiac muscle hypertrophy (GO:0003300)3.07359246
57response to epinephrine (GO:0071871)3.05798280
58heart process (GO:0003015)3.05231767
59heart contraction (GO:0060047)3.05231767
60acetyl-CoA metabolic process (GO:0006084)3.04954894
61hydrogen ion transmembrane transport (GO:1902600)3.04564537
62ventricular cardiac muscle cell action potential (GO:0086005)3.00364884
63oxaloacetate metabolic process (GO:0006107)2.98454243
64establishment of protein localization to mitochondrial membrane (GO:0090151)2.92630245
65regulation of membrane repolarization (GO:0060306)2.91426842
66striated muscle hypertrophy (GO:0014897)2.90167602
67neuron cell-cell adhesion (GO:0007158)2.89871988
68detection of calcium ion (GO:0005513)2.87434958
69fatty acid beta-oxidation (GO:0006635)2.86170925
70actin-mediated cell contraction (GO:0070252)2.85806858
71regulation of glucokinase activity (GO:0033131)2.85624882
72regulation of hexokinase activity (GO:1903299)2.85624882
73proteasome assembly (GO:0043248)2.85561178
74cardiac cell development (GO:0055006)2.85364533
75striated muscle contraction (GO:0006941)2.85260215
76IMP metabolic process (GO:0046040)2.85118626
77cellular response to epinephrine stimulus (GO:0071872)2.82828075
782-oxoglutarate metabolic process (GO:0006103)2.82727097
79ketone body metabolic process (GO:1902224)2.82212656
80skeletal muscle contraction (GO:0003009)2.81494265
81lipid particle organization (GO:0034389)2.80817646
82protein-cofactor linkage (GO:0018065)2.80694364
83response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.79351044
84regulation of striated muscle contraction (GO:0006942)2.78365536
85lysine catabolic process (GO:0006554)2.78199781
86lysine metabolic process (GO:0006553)2.78199781
87response to pheromone (GO:0019236)2.77168411
88presynaptic membrane assembly (GO:0097105)2.74469433
89proton transport (GO:0015992)2.74283140
90maturation of 5.8S rRNA (GO:0000460)2.73609301
91hydrogen transport (GO:0006818)2.73189450
92regulation of mitochondrial translation (GO:0070129)2.72852939
93positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.72731863
94pyrimidine nucleobase catabolic process (GO:0006208)2.71604871
95protein K6-linked ubiquitination (GO:0085020)2.71268840
96carnitine transmembrane transport (GO:1902603)2.70971609
97cardiac muscle tissue morphogenesis (GO:0055008)2.70870555
98cellular respiration (GO:0045333)2.70719681
99purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.69946295
100biotin metabolic process (GO:0006768)2.69289294
101vocalization behavior (GO:0071625)2.69200616
102purine nucleoside triphosphate biosynthetic process (GO:0009145)2.68168216
103ATP hydrolysis coupled proton transport (GO:0015991)2.67913249
104energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.67913249
105adult heart development (GO:0007512)2.67646179
106membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.67631690
107response to muscle activity (GO:0014850)2.66414510
108positive regulation of mitochondrial fission (GO:0090141)2.65806151
109L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.63259108
110creatine metabolic process (GO:0006600)2.63150924
111branched-chain amino acid metabolic process (GO:0009081)2.61551066
112protein deneddylation (GO:0000338)2.60904347
113cullin deneddylation (GO:0010388)2.60150926
114positive regulation of heart rate (GO:0010460)2.60130463
115IMP biosynthetic process (GO:0006188)2.57310179
116response to caffeine (GO:0031000)2.47864079
117mitochondrial RNA metabolic process (GO:0000959)2.46095390
118intracellular protein transmembrane import (GO:0044743)2.41994661
119DNA damage response, detection of DNA damage (GO:0042769)2.38978847
120gluconeogenesis (GO:0006094)2.38256310
121C4-dicarboxylate transport (GO:0015740)2.37993116
122somatic diversification of immune receptors via somatic mutation (GO:0002566)2.32936299
123somatic hypermutation of immunoglobulin genes (GO:0016446)2.32936299
124organelle disassembly (GO:1903008)2.29478703
125ribonucleoprotein complex disassembly (GO:0032988)2.29439053
126DNA double-strand break processing (GO:0000729)2.28562164
127nonmotile primary cilium assembly (GO:0035058)2.28493054
128positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.27951441
129actin filament-based movement (GO:0030048)2.25365320
130chromatin remodeling at centromere (GO:0031055)2.24015279
131CENP-A containing nucleosome assembly (GO:0034080)2.21680893
132peptidyl-histidine modification (GO:0018202)2.21678520
133muscle cell cellular homeostasis (GO:0046716)2.21308173
134L-serine metabolic process (GO:0006563)2.19874657
135water-soluble vitamin biosynthetic process (GO:0042364)2.19843277
136respiratory chain complex IV assembly (GO:0008535)2.19647739
137response to inactivity (GO:0014854)2.18933940
138amino acid activation (GO:0043038)2.18587506
139tRNA aminoacylation (GO:0043039)2.18587506

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.07320949
2GBX2_23144817_ChIP-Seq_PC3_Human3.95559109
3GABP_17652178_ChIP-ChIP_JURKAT_Human2.97601447
4TAF15_26573619_Chip-Seq_HEK293_Human2.94705869
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.93867481
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.76896446
7ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.69290716
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.52603558
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.42401938
10VDR_22108803_ChIP-Seq_LS180_Human2.40457256
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.36608696
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.27205198
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.24544480
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.18654664
15PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.16040496
16* ELK1_19687146_ChIP-ChIP_HELA_Human2.09459008
17POU3F2_20337985_ChIP-ChIP_501MEL_Human2.08496742
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.06139701
19CTBP2_25329375_ChIP-Seq_LNCAP_Human1.85830469
20CTBP1_25329375_ChIP-Seq_LNCAP_Human1.85323440
21EWS_26573619_Chip-Seq_HEK293_Human1.84366842
22FUS_26573619_Chip-Seq_HEK293_Human1.78136297
23PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72293880
24CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.69840189
25EP300_21415370_ChIP-Seq_HL-1_Mouse1.69208028
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.67483594
27MYC_18555785_ChIP-Seq_MESCs_Mouse1.65251538
28SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.65034122
29PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.63954808
30P300_19829295_ChIP-Seq_ESCs_Human1.63208541
31SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.62365949
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.60846057
33PCGF2_27294783_Chip-Seq_ESCs_Mouse1.58926948
34* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.56551888
35E2F4_17652178_ChIP-ChIP_JURKAT_Human1.55412313
36SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.55028228
37KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.52956730
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.52764988
39* MYC_18940864_ChIP-ChIP_HL60_Human1.51525669
40PADI4_21655091_ChIP-ChIP_MCF-7_Human1.49346315
41JARID2_20064375_ChIP-Seq_MESCs_Mouse1.49069137
42* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48157286
43ER_23166858_ChIP-Seq_MCF-7_Human1.47552129
44CBX2_27304074_Chip-Seq_ESCs_Mouse1.45377250
45EZH2_27304074_Chip-Seq_ESCs_Mouse1.44591497
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.43779046
47VDR_23849224_ChIP-Seq_CD4+_Human1.43662086
48* SMAD4_21799915_ChIP-Seq_A2780_Human1.43503457
49REST_21632747_ChIP-Seq_MESCs_Mouse1.43377033
50DCP1A_22483619_ChIP-Seq_HELA_Human1.38740272
51GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.35573224
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.34781024
53ZNF274_21170338_ChIP-Seq_K562_Hela1.33476079
54REST_18959480_ChIP-ChIP_MESCs_Mouse1.31665994
55* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31043034
56EED_16625203_ChIP-ChIP_MESCs_Mouse1.29817524
57JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.29532369
58RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.29364908
59HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.28813119
60TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26716567
61AR_21572438_ChIP-Seq_LNCaP_Human1.25908402
62RBPJ_22232070_ChIP-Seq_NCS_Mouse1.25108239
63* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.24666984
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.24486887
65* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.23792268
66PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.23158717
67NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.21979883
68SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20550155
69SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20219211
70E2F7_22180533_ChIP-Seq_HELA_Human1.19861733
71MYC_19030024_ChIP-ChIP_MESCs_Mouse1.18729899
72* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.17900659
73SRF_21415370_ChIP-Seq_HL-1_Mouse1.17391872
74EZH2_18974828_ChIP-Seq_MESCs_Mouse1.16220226
75RNF2_18974828_ChIP-Seq_MESCs_Mouse1.16220226
76BMI1_23680149_ChIP-Seq_NPCS_Mouse1.15956014
77THAP11_20581084_ChIP-Seq_MESCs_Mouse1.14125129
78MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.13316495
79IGF1R_20145208_ChIP-Seq_DFB_Human1.13073417
80CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12309368
81EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.12102509
82SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.11978809
83* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.11775922
84AR_25329375_ChIP-Seq_VCAP_Human1.11750192
85FOXP3_21729870_ChIP-Seq_TREG_Human1.11683164
86SOX2_21211035_ChIP-Seq_LN229_Gbm1.11621770
87TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11447912
88PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.10680925
89RNF2_27304074_Chip-Seq_NSC_Mouse1.09864186
90SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.09471039
91KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08845615
92MYC_18358816_ChIP-ChIP_MESCs_Mouse1.08171889
93* STAT3_23295773_ChIP-Seq_U87_Human1.08017820
94TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.07152825
95HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.06832521
96* NANOG_18555785_Chip-Seq_ESCs_Mouse1.06634122
97TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06319136
98EZH2_27294783_Chip-Seq_ESCs_Mouse1.06041709
99* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.06011141
100MTF2_20144788_ChIP-Seq_MESCs_Mouse1.05510750
101NFE2_27457419_Chip-Seq_LIVER_Mouse1.05509633
102* TCF4_23295773_ChIP-Seq_U87_Human1.05444493
103EZH2_27294783_Chip-Seq_NPCs_Mouse1.05346590
104SOX9_26525672_Chip-Seq_HEART_Mouse1.04522239
105* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04130326
106IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.04119351
107CBP_20019798_ChIP-Seq_JUKART_Human1.04119351
108GABP_19822575_ChIP-Seq_HepG2_Human1.03834985
109MYCN_18555785_ChIP-Seq_MESCs_Mouse1.03411743
110DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.03389468
111SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.03368915
112* E2F1_18555785_Chip-Seq_ESCs_Mouse1.02647283
113* STAT3_18555785_Chip-Seq_ESCs_Mouse1.02449663
114HTT_18923047_ChIP-ChIP_STHdh_Human1.02106139
115JUN_21703547_ChIP-Seq_K562_Human1.02036016
116AR_21909140_ChIP-Seq_LNCAP_Human1.01587483
117* P53_22387025_ChIP-Seq_ESCs_Mouse1.01259458
118MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01064272
119TTF2_22483619_ChIP-Seq_HELA_Human1.00999968
120SOX2_19829295_ChIP-Seq_ESCs_Human1.00647579
121NANOG_19829295_ChIP-Seq_ESCs_Human1.00647579
122* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00466211
123NANOG_16153702_ChIP-ChIP_HESCs_Human1.00133174
124TP53_22573176_ChIP-Seq_HFKS_Human0.99579130
125NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.99265189
126SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.99133269
127MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.99041194
128MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98805944
129YY1_21170310_ChIP-Seq_MESCs_Mouse0.98598348
130MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.98485355
131* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98407592
132* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.97295421
133TAL1_26923725_Chip-Seq_HPCs_Mouse0.97139714
134RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96314540
135* SOX2_18555785_Chip-Seq_ESCs_Mouse0.95933635
136POU5F1_16153702_ChIP-ChIP_HESCs_Human0.95398865
137JARID2_20075857_ChIP-Seq_MESCs_Mouse0.94859505
138SOX2_16153702_ChIP-ChIP_HESCs_Human0.93993318
139PCGF2_27294783_Chip-Seq_NPCs_Mouse0.88898461
140POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.87926282
141CRX_20693478_ChIP-Seq_RETINA_Mouse0.87402578
142PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.86633230
143* CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.86188538

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue5.32141221
2MP0002837_dystrophic_cardiac_calcinosis4.96905739
3MP0000751_myopathy3.56482338
4MP0004215_abnormal_myocardial_fiber3.40956277
5MP0004084_abnormal_cardiac_muscle3.14336427
6MP0003880_abnormal_central_pattern3.03223258
7MP0004036_abnormal_muscle_relaxation2.89617185
8MP0000749_muscle_degeneration2.71668809
9MP0005330_cardiomyopathy2.44153543
10MP0001529_abnormal_vocalization2.36771384
11MP0006036_abnormal_mitochondrial_physio2.33241071
12MP0004145_abnormal_muscle_electrophysio2.27919952
13MP0004130_abnormal_muscle_cell2.22512844
14MP0003137_abnormal_impulse_conducting2.09449892
15MP0004484_altered_response_of2.09286743
16MP0005620_abnormal_muscle_contractility1.99159865
17MP0002972_abnormal_cardiac_muscle1.96604138
18MP0004859_abnormal_synaptic_plasticity1.96289889
19MP0006035_abnormal_mitochondrial_morpho1.75735053
20MP0004087_abnormal_muscle_fiber1.75137441
21MP0002106_abnormal_muscle_physiology1.74694775
22MP0003221_abnormal_cardiomyocyte_apopto1.73446705
23MP0009046_muscle_twitch1.70433736
24MP0003806_abnormal_nucleotide_metabolis1.68264782
25MP0003635_abnormal_synaptic_transmissio1.64994222
26MP0009745_abnormal_behavioral_response1.62497783
27MP0002269_muscular_atrophy1.62427841
28MP0008775_abnormal_heart_ventricle1.59329960
29MP0004270_analgesia1.55936343
30MP0002272_abnormal_nervous_system1.55246170
31MP0002638_abnormal_pupillary_reflex1.54407193
32MP0003950_abnormal_plasma_membrane1.51155704
33MP0002736_abnormal_nociception_after1.50675949
34MP0005670_abnormal_white_adipose1.50576853
35MP0004085_abnormal_heartbeat1.49819847
36MP0006138_congestive_heart_failure1.48056239
37MP0001905_abnormal_dopamine_level1.47343525
38MP0002064_seizures1.47111519
39MP0001544_abnormal_cardiovascular_syste1.43151641
40MP0005385_cardiovascular_system_phenoty1.43151641
41MP0005369_muscle_phenotype1.42178512
42MP0005451_abnormal_body_composition1.41953669
43MP0002332_abnormal_exercise_endurance1.38801904
44MP0002063_abnormal_learning/memory/cond1.38126071
45MP0001440_abnormal_grooming_behavior1.38105627
46MP0008058_abnormal_DNA_repair1.37489771
47MP0002735_abnormal_chemical_nociception1.36872287
48MP0001968_abnormal_touch/_nociception1.36230612
49MP0000759_abnormal_skeletal_muscle1.34548648
50MP0000747_muscle_weakness1.34340271
51MP0003890_abnormal_embryonic-extraembry1.33392308
52MP0005386_behavior/neurological_phenoty1.33266310
53MP0004924_abnormal_behavior1.33266310
54MP0004142_abnormal_muscle_tone1.31548364
55MP0002572_abnormal_emotion/affect_behav1.31440810
56MP0001486_abnormal_startle_reflex1.29637066
57MP0000750_abnormal_muscle_regeneration1.29150719
58MP0003718_maternal_effect1.27569566
59MP0002822_catalepsy1.27436578
60MP0004147_increased_porphyrin_level1.27040093
61MP0005187_abnormal_penis_morphology1.26105187
62MP0002067_abnormal_sensory_capabilities1.25792515
63MP0006072_abnormal_retinal_apoptosis1.24903567
64MP0002234_abnormal_pharynx_morphology1.24692157
65MP0000013_abnormal_adipose_tissue1.23087925
66MP0002938_white_spotting1.22594171
67MP0002102_abnormal_ear_morphology1.22075277
68MP0000372_irregular_coat_pigmentation1.20755263
69MP0005666_abnormal_adipose_tissue1.17132466
70MP0004233_abnormal_muscle_weight1.16436080
71MP0006276_abnormal_autonomic_nervous1.16267537
72MP0009697_abnormal_copulation1.14434343
73MP0008260_abnormal_autophagy1.14180331
74MP0001984_abnormal_olfaction1.13413780
75MP0008877_abnormal_DNA_methylation1.13154913
76MP0002734_abnormal_mechanical_nocicepti1.11164558
77MP0005646_abnormal_pituitary_gland1.11095969
78MP0010030_abnormal_orbit_morphology1.09876989
79MP0005253_abnormal_eye_physiology1.07023796
80MP0003937_abnormal_limbs/digits/tail_de1.06596067
81MP0004133_heterotaxia1.05984825
82MP0002160_abnormal_reproductive_system1.04505096
83MP0002127_abnormal_cardiovascular_syste1.04184152
84MP0003941_abnormal_skin_development1.03400887
85MP0008789_abnormal_olfactory_epithelium1.03218046
86MP0003693_abnormal_embryo_hatching1.02339349
87MP0005085_abnormal_gallbladder_physiolo1.01860695
88MP0003567_abnormal_fetal_cardiomyocyte1.01259286
89MP0001299_abnormal_eye_distance/1.00806170
90MP0001485_abnormal_pinna_reflex0.99487217
91MP0010630_abnormal_cardiac_muscle0.99412187
92MP0010094_abnormal_chromosome_stability0.97772042
93MP0003186_abnormal_redox_activity0.97224286
94MP0002876_abnormal_thyroid_physiology0.95737085
95MP0000778_abnormal_nervous_system0.95347544
96MP0003122_maternal_imprinting0.92445662
97MP0005266_abnormal_metabolism0.91840964
98MP0004957_abnormal_blastocyst_morpholog0.89854859
99MP0005645_abnormal_hypothalamus_physiol0.88757336
100MP0005551_abnormal_eye_electrophysiolog0.87773361
101MP0003879_abnormal_hair_cell0.86965845
102MP0006292_abnormal_olfactory_placode0.86958192
103MP0001188_hyperpigmentation0.85993280
104MP0000647_abnormal_sebaceous_gland0.84420525
105MP0004043_abnormal_pH_regulation0.84362051
106MP0008875_abnormal_xenobiotic_pharmacok0.84041880
107MP0004185_abnormal_adipocyte_glucose0.83664231
108MP0002090_abnormal_vision0.83447260
109MP0008995_early_reproductive_senescence0.82097506
110MP0008932_abnormal_embryonic_tissue0.81789497
111MP0003315_abnormal_perineum_morphology0.81687206
112MP0002066_abnormal_motor_capabilities/c0.81431250
113MP0003329_amyloid_beta_deposits0.81293520
114MP0005535_abnormal_body_temperature0.80828020
115MP0005423_abnormal_somatic_nervous0.80810871
116MP0001501_abnormal_sleep_pattern0.80403494
117MP0002653_abnormal_ependyma_morphology0.80391078
118MP0002184_abnormal_innervation0.77075492
119MP0005365_abnormal_bile_salt0.75574908
120MP0001727_abnormal_embryo_implantation0.73097484
121MP0002229_neurodegeneration0.70843226
122MP0005332_abnormal_amino_acid0.70573229
123MP0000358_abnormal_cell_content/0.70504035
124MP0000230_abnormal_systemic_arterial0.70451152
125MP0001661_extended_life_span0.69837170
126MP0003136_yellow_coat_color0.68911423
127MP0005394_taste/olfaction_phenotype0.68743614
128MP0003195_calcinosis0.66881877
129MP0003787_abnormal_imprinting0.66835233
130MP0001970_abnormal_pain_threshold0.65044003
131MP0002882_abnormal_neuron_morphology0.64123692
132MP0005410_abnormal_fertilization0.62255934
133MP0001963_abnormal_hearing_physiology0.62212326
134MP0002971_abnormal_brown_adipose0.61885384

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.10590621
2Abnormal mitochondria in muscle tissue (HP:0008316)4.92107316
3Acute encephalopathy (HP:0006846)4.54093852
4Sudden death (HP:0001699)4.29102444
5Mitochondrial inheritance (HP:0001427)4.28599927
6Progressive macrocephaly (HP:0004481)4.28167987
7Hepatocellular necrosis (HP:0001404)4.21492114
8Hepatic necrosis (HP:0002605)4.15533433
9Exercise-induced myalgia (HP:0003738)4.07577256
10* Abnormality of glycolysis (HP:0004366)4.07506341
11* Increased serum pyruvate (HP:0003542)4.07506341
12Increased CSF lactate (HP:0002490)4.03792743
13Muscle hypertrophy of the lower extremities (HP:0008968)3.94203702
14Calf muscle hypertrophy (HP:0008981)3.94104237
15Focal motor seizures (HP:0011153)3.89492836
16Cerebral edema (HP:0002181)3.80135249
17* Lactic acidosis (HP:0003128)3.47963622
18Exercise-induced muscle cramps (HP:0003710)3.38484737
19* Abnormality of alanine metabolism (HP:0010916)3.35291179
20* Hyperalaninemia (HP:0003348)3.35291179
21* Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.35291179
22Myoglobinuria (HP:0002913)3.25224330
23Atrial fibrillation (HP:0005110)3.24828966
24Increased muscle lipid content (HP:0009058)3.21484404
25Muscle fiber splitting (HP:0003555)3.20929909
26Increased intramyocellular lipid droplets (HP:0012240)3.17292747
27Rimmed vacuoles (HP:0003805)3.17027247
28Ventricular tachycardia (HP:0004756)3.14477923
29Exercise intolerance (HP:0003546)3.11883701
30Abnormality of the calf musculature (HP:0001430)3.11102167
31Type 1 muscle fiber predominance (HP:0003803)3.08052829
32Syncope (HP:0001279)3.04086009
33Primary atrial arrhythmia (HP:0001692)2.98852068
34Increased serum lactate (HP:0002151)2.97641054
35Rhabdomyolysis (HP:0003201)2.95592222
36Respiratory failure (HP:0002878)2.95049101
37Palpitations (HP:0001962)2.94631107
38Lipid accumulation in hepatocytes (HP:0006561)2.91457988
39Supraventricular tachycardia (HP:0004755)2.88459514
40Optic disc pallor (HP:0000543)2.84053888
41Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.83583811
42Decreased activity of mitochondrial respiratory chain (HP:0008972)2.83583811
43Increased hepatocellular lipid droplets (HP:0006565)2.81729533
44Pheochromocytoma (HP:0002666)2.77645315
45Supraventricular arrhythmia (HP:0005115)2.77533611
46Hyperventilation (HP:0002883)2.76607989
47Lipoatrophy (HP:0100578)2.72691342
48Distal arthrogryposis (HP:0005684)2.66428087
49Leukodystrophy (HP:0002415)2.61115614
50Neuroendocrine neoplasm (HP:0100634)2.60063944
51Dicarboxylic aciduria (HP:0003215)2.58357325
52Abnormality of dicarboxylic acid metabolism (HP:0010995)2.58357325
53Subaortic stenosis (HP:0001682)2.53741608
54Abnormality of the left ventricular outflow tract (HP:0011103)2.53741608
55Abnormality of fatty-acid metabolism (HP:0004359)2.51388011
56Lethargy (HP:0001254)2.48943311
57Bundle branch block (HP:0011710)2.48119767
583-Methylglutaconic aciduria (HP:0003535)2.43856945
59Left ventricular hypertrophy (HP:0001712)2.42362421
60Hyperglycinuria (HP:0003108)2.41013282
61Ketoacidosis (HP:0001993)2.40304973
62EMG: myopathic abnormalities (HP:0003458)2.33337868
63Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.33081189
64Dilated cardiomyopathy (HP:0001644)2.32711627
65CNS demyelination (HP:0007305)2.28545905
66Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.28328175
67Abnormality of serine family amino acid metabolism (HP:0010894)2.23593628
68Abnormality of glycine metabolism (HP:0010895)2.23593628
69Prolonged QT interval (HP:0001657)2.23265804
70Medial flaring of the eyebrow (HP:0010747)2.23075834
71Atonic seizures (HP:0010819)2.22129893
72Methylmalonic acidemia (HP:0002912)2.21970269
73Neck muscle weakness (HP:0000467)2.19479653
74Progressive external ophthalmoplegia (HP:0000590)2.15305585
75Epileptic encephalopathy (HP:0200134)2.14137140
76Ragged-red muscle fibers (HP:0003200)2.12838866
77Muscle fiber inclusion bodies (HP:0100299)2.12625360
78Ventricular arrhythmia (HP:0004308)2.12582408
79Hyporeflexia of lower limbs (HP:0002600)2.12125491
80Myotonia (HP:0002486)2.11106151
81Febrile seizures (HP:0002373)2.10562853
82Renal Fanconi syndrome (HP:0001994)2.10065185
83Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.07319282
84Gait imbalance (HP:0002141)2.06438794
85Methylmalonic aciduria (HP:0012120)2.06293838
86Ketosis (HP:0001946)2.04039403
87Congenital primary aphakia (HP:0007707)2.02568711
88Hyperglycinemia (HP:0002154)2.01505655
89Absent phalangeal crease (HP:0006109)1.99780591
90Focal seizures (HP:0007359)1.95951708
91Muscle stiffness (HP:0003552)1.95820932
92Microvesicular hepatic steatosis (HP:0001414)1.95649873
93Heart block (HP:0012722)1.95390521
94Hyperammonemia (HP:0001987)1.95273756
95Absence seizures (HP:0002121)1.94874411
96Nemaline bodies (HP:0003798)1.94126799
97Calcaneovalgus deformity (HP:0001848)1.93621045
98Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.92477688
99X-linked dominant inheritance (HP:0001423)1.92275730
100Difficulty running (HP:0009046)1.92268823
101Type II lissencephaly (HP:0007260)1.91987953
102Abnormal finger flexion creases (HP:0006143)1.91553556
103Generalized tonic-clonic seizures (HP:0002069)1.91217664
104Progressive inability to walk (HP:0002505)1.90636917
105Right ventricular cardiomyopathy (HP:0011663)1.89605207
106Respiratory difficulties (HP:0002880)1.89559171
107Nephrogenic diabetes insipidus (HP:0009806)1.88834323
108Dialeptic seizures (HP:0011146)1.86023702
109Frequent falls (HP:0002359)1.84468335
110Vomiting (HP:0002013)1.83105647
111Central scotoma (HP:0000603)1.82956767
112Hypoglycemic coma (HP:0001325)1.82617796
113* Abnormality of serum amino acid levels (HP:0003112)1.82065287
114Neoplasm of the adrenal gland (HP:0100631)1.81927306
115Abnormal EKG (HP:0003115)1.81883016
116Broad-based gait (HP:0002136)1.81517399
117Renal cortical cysts (HP:0000803)1.81134037
118Ventricular fibrillation (HP:0001663)1.80497438
119Myopathic facies (HP:0002058)1.78972320
120Limb-girdle muscle atrophy (HP:0003797)1.77615108
121Shoulder girdle muscle weakness (HP:0003547)1.76504842
122Birth length less than 3rd percentile (HP:0003561)1.76071542
123Pancreatic fibrosis (HP:0100732)1.76027906
124Inability to walk (HP:0002540)1.75926602
125Areflexia of lower limbs (HP:0002522)1.73588347
126Abnormality of the labia minora (HP:0012880)1.71809687
127Pancreatic cysts (HP:0001737)1.71174816
128Hyperinsulinemic hypoglycemia (HP:0000825)1.69659252
129Deformed tarsal bones (HP:0008119)1.69476602
130Genital tract atresia (HP:0001827)1.68522385
131Molar tooth sign on MRI (HP:0002419)1.65399048
132Abnormality of midbrain morphology (HP:0002418)1.65399048
133Type I transferrin isoform profile (HP:0003642)1.62709801
134Vaginal atresia (HP:0000148)1.62359655
135Delayed gross motor development (HP:0002194)1.60659366
136Abnormality of the anterior horn cell (HP:0006802)1.59177803
137Degeneration of anterior horn cells (HP:0002398)1.59177803
138Cerebellar dysplasia (HP:0007033)1.58531270
139Poor coordination (HP:0002370)1.58101865
140EMG: neuropathic changes (HP:0003445)1.57944122

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK34.08677654
2PDK44.08677654
3CASK4.02776441
4OBSCN2.84050002
5PHKG12.47058843
6PHKG22.47058843
7PDK22.46926621
8MAP3K42.41710855
9MUSK2.39940783
10MAP2K72.37634601
11EPHA42.28005350
12NEK12.25880941
13MYLK2.07194554
14PINK11.96662678
15MAP3K121.94769435
16BCKDK1.88746576
17MAP2K41.84631346
18EIF2AK31.81134927
19MAP3K61.79437330
20NME11.72434307
21ERBB31.71444243
22TTN1.64468079
23PRPF4B1.61648746
24MARK11.60084152
25LMTK21.55940654
26MAP4K21.54953045
27PLK21.54087295
28CCNB11.51921053
29OXSR11.51786927
30NTRK31.49470423
31WEE11.39686310
32AKT31.36025557
33STK391.35250979
34LIMK11.34644775
35GRK71.33656548
36STK38L1.33106808
37ADRBK21.30630979
38MAP3K91.29901310
39TNIK1.28862554
40STK161.23090631
41BRSK21.22100198
42ERBB41.21249828
43BRAF1.19833941
44BMPR21.19644968
45TRIM281.16471581
46CAMK2A1.16047430
47PIK3CA1.15587961
48WNK31.13673036
49BCR1.12227835
50PKN11.07291946
51MAPK131.06561361
52PNCK1.06247813
53CDC71.04431635
54CDK191.03342539
55CAMK2D1.02330731
56ACVR1B0.93608525
57VRK10.93086431
58DYRK20.92112909
59EIF2AK10.91218930
60DYRK30.89221350
61DMPK0.88835050
62CSNK1G10.87916255
63FRK0.85707851
64EPHA30.85466141
65RPS6KA40.84992600
66NUAK10.83405616
67PLK10.83266146
68ZAK0.82608776
69CAMK2B0.80203131
70PAK30.80096012
71MINK10.79448476
72CSNK1G30.79189176
73KSR10.78555984
74PLK40.76572856
75TSSK60.74519907
76GRK10.74442972
77MAPKAPK50.73474890
78PRKCE0.71201137
79MKNK10.71181948
80TTK0.70970201
81VRK20.70445915
82STK240.70344491
83MAP3K50.70240273
84SGK2230.69919328
85SGK4940.69919328
86CSNK1A1L0.69556675
87CAMK2G0.69385391
88BUB10.67200666
89PAK60.67068362
90NEK20.66948804
91TIE10.65807453
92WNK40.65587199
93ROCK20.65018594
94MET0.65000558
95MAPK120.64770494
96ARAF0.64677630
97CAMKK20.64245054
98PRKCG0.64137494
99BMPR1B0.61532985
100LATS20.57739284
101PRKAA10.57161186
102AKT20.56800808
103PRKACA0.56718845
104PRKAA20.56573732
105NTRK20.55591274
106SGK20.55398295
107DAPK10.54587536
108CHEK20.53879916
109CAMK40.52646169
110CDK80.52615348
111PTK2B0.51064190
112PBK0.49871959
113GRK50.48481447
114DAPK20.47916737
115TAF10.47673055
116RPS6KA50.47639600
117CSNK1E0.47591166
118LATS10.47547130
119STK30.46554046
120ATR0.46308859
121MST40.46143901
122PRKACB0.45384488
123MKNK20.45168478
124ATM0.45085450
125CAMK1D0.43363094
126CDK50.43362909
127MAP2K10.41656149
128BRSK10.41202726
129RAF10.40536751
130SRPK10.40425719
131ROCK10.40030928
132INSRR0.39953918
133CAMK10.37903227
134PLK30.37465807
135SGK10.35807237
136EIF2AK20.34674375
137DAPK30.32131402
138PRKD10.31344065
139CDK30.31183110
140CSNK1G20.29867349
141DYRK1A0.28190891
142ADRBK10.27572399
143CDK180.27449662
144AURKA0.23745718

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.65100246
2Oxidative phosphorylation_Homo sapiens_hsa001904.06285017
3Parkinsons disease_Homo sapiens_hsa050123.44429093
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.39207515
5Propanoate metabolism_Homo sapiens_hsa006403.35704440
6Cardiac muscle contraction_Homo sapiens_hsa042602.88375286
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.81064310
8Alzheimers disease_Homo sapiens_hsa050102.63654921
9Pyruvate metabolism_Homo sapiens_hsa006202.57236203
10Huntingtons disease_Homo sapiens_hsa050162.47656508
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.40417147
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.39845003
13Fatty acid degradation_Homo sapiens_hsa000712.19265207
14Butanoate metabolism_Homo sapiens_hsa006502.18499621
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.17280798
16Carbon metabolism_Homo sapiens_hsa012002.11356816
17Fatty acid metabolism_Homo sapiens_hsa012122.06796545
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.04087040
19Fatty acid elongation_Homo sapiens_hsa000621.98163703
20Protein export_Homo sapiens_hsa030601.84511961
21Nicotine addiction_Homo sapiens_hsa050331.78307712
22Collecting duct acid secretion_Homo sapiens_hsa049661.51255150
23Vitamin B6 metabolism_Homo sapiens_hsa007501.50368598
24Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.45129944
25Selenocompound metabolism_Homo sapiens_hsa004501.44584345
26Nitrogen metabolism_Homo sapiens_hsa009101.41928102
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.34782580
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.34514019
29Dilated cardiomyopathy_Homo sapiens_hsa054141.34402455
30Mismatch repair_Homo sapiens_hsa034301.32267022
31Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.31312432
32Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.28704769
33beta-Alanine metabolism_Homo sapiens_hsa004101.24744640
34RNA degradation_Homo sapiens_hsa030181.20162399
35One carbon pool by folate_Homo sapiens_hsa006701.19961081
36Nucleotide excision repair_Homo sapiens_hsa034201.19378979
37Peroxisome_Homo sapiens_hsa041461.17875159
38Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.15467275
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.15356479
40Biosynthesis of amino acids_Homo sapiens_hsa012301.13366572
41Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.13192280
42Synaptic vesicle cycle_Homo sapiens_hsa047211.11410080
43Homologous recombination_Homo sapiens_hsa034401.10631142
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.09400269
45Fanconi anemia pathway_Homo sapiens_hsa034601.06861998
46RNA transport_Homo sapiens_hsa030131.03151677
47Proteasome_Homo sapiens_hsa030501.02523291
48Fatty acid biosynthesis_Homo sapiens_hsa000610.99015690
49PPAR signaling pathway_Homo sapiens_hsa033200.98060775
50Non-homologous end-joining_Homo sapiens_hsa034500.95548313
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.91340980
52Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.90169229
53DNA replication_Homo sapiens_hsa030300.88681400
54Calcium signaling pathway_Homo sapiens_hsa040200.82782991
55GABAergic synapse_Homo sapiens_hsa047270.80828859
56Arginine and proline metabolism_Homo sapiens_hsa003300.80202252
57Morphine addiction_Homo sapiens_hsa050320.79822727
58Arginine biosynthesis_Homo sapiens_hsa002200.79753084
59Taste transduction_Homo sapiens_hsa047420.78134431
60Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.77413442
61Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.76918045
62Glutamatergic synapse_Homo sapiens_hsa047240.76390752
63Circadian entrainment_Homo sapiens_hsa047130.74471039
64* Metabolic pathways_Homo sapiens_hsa011000.74172189
65Tryptophan metabolism_Homo sapiens_hsa003800.73726484
66Folate biosynthesis_Homo sapiens_hsa007900.71723676
67RNA polymerase_Homo sapiens_hsa030200.68579510
68Ribosome_Homo sapiens_hsa030100.66358839
69Phenylalanine metabolism_Homo sapiens_hsa003600.62890717
70Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.60701742
71Serotonergic synapse_Homo sapiens_hsa047260.58757604
72Pyrimidine metabolism_Homo sapiens_hsa002400.56851976
73Primary bile acid biosynthesis_Homo sapiens_hsa001200.56471554
74Oxytocin signaling pathway_Homo sapiens_hsa049210.56190464
75Circadian rhythm_Homo sapiens_hsa047100.55474936
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.53774103
77Glucagon signaling pathway_Homo sapiens_hsa049220.53765415
78Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.53470373
79Tyrosine metabolism_Homo sapiens_hsa003500.53245295
80Spliceosome_Homo sapiens_hsa030400.51571533
81Long-term potentiation_Homo sapiens_hsa047200.51386816
82Olfactory transduction_Homo sapiens_hsa047400.51080525
83Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.50512926
84Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.50429618
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49584857
86Regulation of autophagy_Homo sapiens_hsa041400.49269103
87Amphetamine addiction_Homo sapiens_hsa050310.47785675
88Phototransduction_Homo sapiens_hsa047440.47697837
89Vibrio cholerae infection_Homo sapiens_hsa051100.47480781
90Glycerolipid metabolism_Homo sapiens_hsa005610.45659755
91Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44807520
92Dopaminergic synapse_Homo sapiens_hsa047280.44075049
93Base excision repair_Homo sapiens_hsa034100.42635283
94Maturity onset diabetes of the young_Homo sapiens_hsa049500.42415359
95Renin secretion_Homo sapiens_hsa049240.41679290
96Purine metabolism_Homo sapiens_hsa002300.41138539
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.39948177
98cGMP-PKG signaling pathway_Homo sapiens_hsa040220.38688615
99Fat digestion and absorption_Homo sapiens_hsa049750.37324533
100Ovarian steroidogenesis_Homo sapiens_hsa049130.37306385
101Basal transcription factors_Homo sapiens_hsa030220.36275511
102Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35905661
103Salivary secretion_Homo sapiens_hsa049700.34949908
104Cell cycle_Homo sapiens_hsa041100.34645335
105Glycerophospholipid metabolism_Homo sapiens_hsa005640.33117526
106Ether lipid metabolism_Homo sapiens_hsa005650.31118384
107Linoleic acid metabolism_Homo sapiens_hsa005910.29980752
108Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.29945595
109Oocyte meiosis_Homo sapiens_hsa041140.29803259
110Mineral absorption_Homo sapiens_hsa049780.29510930
111Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.29185158
112alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.29093320
113Long-term depression_Homo sapiens_hsa047300.28058870
114Vascular smooth muscle contraction_Homo sapiens_hsa042700.26989723
115Starch and sucrose metabolism_Homo sapiens_hsa005000.26878666
116Pentose phosphate pathway_Homo sapiens_hsa000300.25669044
117Steroid biosynthesis_Homo sapiens_hsa001000.25147526
118Glutathione metabolism_Homo sapiens_hsa004800.25044687
119Sulfur metabolism_Homo sapiens_hsa009200.25010747
120Insulin secretion_Homo sapiens_hsa049110.24836990
121Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.24755270
122Gastric acid secretion_Homo sapiens_hsa049710.24104903
123Steroid hormone biosynthesis_Homo sapiens_hsa001400.23649300
124Cholinergic synapse_Homo sapiens_hsa047250.23629810
125Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.22515167
126Fructose and mannose metabolism_Homo sapiens_hsa000510.21629494
127Sulfur relay system_Homo sapiens_hsa041220.21451042

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