PDHB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and carbon dioxide, and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 beta subunit. Mutations in this gene are associated with pyruvate dehydrogenase E1-beta deficiency. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.88529660
2* tricarboxylic acid cycle (GO:0006099)7.84167331
3energy coupled proton transport, down electrochemical gradient (GO:0015985)7.21709909
4ATP synthesis coupled proton transport (GO:0015986)7.21709909
5NADH metabolic process (GO:0006734)6.78120721
6mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.75725796
7respiratory electron transport chain (GO:0022904)6.59963620
8electron transport chain (GO:0022900)6.44046016
9oxidative phosphorylation (GO:0006119)6.01343233
10* regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.80367682
11* regulation of acyl-CoA biosynthetic process (GO:0050812)5.71744024
12* regulation of cofactor metabolic process (GO:0051193)5.37197123
13* regulation of coenzyme metabolic process (GO:0051196)5.37197123
14succinate metabolic process (GO:0006105)5.31576440
15proteasome assembly (GO:0043248)4.80959555
16carnitine shuttle (GO:0006853)4.47520920
17oxaloacetate metabolic process (GO:0006107)4.45628976
18ATP biosynthetic process (GO:0006754)4.37466252
19establishment of integrated proviral latency (GO:0075713)4.28209856
20negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.26813344
21sarcomere organization (GO:0045214)4.26637052
22branched-chain amino acid catabolic process (GO:0009083)4.23075677
23* regulation of sulfur metabolic process (GO:0042762)4.18788620
24inner mitochondrial membrane organization (GO:0007007)4.17325315
25chromatin remodeling at centromere (GO:0031055)4.11873288
26fatty acid transmembrane transport (GO:1902001)4.07664171
27CENP-A containing nucleosome assembly (GO:0034080)4.05767610
28ubiquinone biosynthetic process (GO:0006744)4.05105172
29quinone biosynthetic process (GO:1901663)4.05105172
30mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.03702337
31mitochondrial respiratory chain complex I assembly (GO:0032981)4.03702337
32NADH dehydrogenase complex assembly (GO:0010257)4.03702337
33cardiac myofibril assembly (GO:0055003)4.02987763
34positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.98806726
35negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.97142599
36aerobic respiration (GO:0009060)3.89177186
37protein neddylation (GO:0045116)3.86278114
38protein complex biogenesis (GO:0070271)3.82541222
39lysine metabolic process (GO:0006553)3.79257513
40lysine catabolic process (GO:0006554)3.79257513
41regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.79221497
42negative regulation of potassium ion transmembrane transport (GO:1901380)3.78178099
43regulation of sequestering of triglyceride (GO:0010889)3.76265911
44regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.75042942
45regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.73408457
46purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.71955222
47purine nucleoside triphosphate biosynthetic process (GO:0009145)3.71115966
48actin-myosin filament sliding (GO:0033275)3.70672910
49muscle filament sliding (GO:0030049)3.70672910
50chaperone-mediated protein transport (GO:0072321)3.66944186
51establishment of protein localization to mitochondrial membrane (GO:0090151)3.66392518
52positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.65009506
53ubiquinone metabolic process (GO:0006743)3.64444967
54aspartate family amino acid catabolic process (GO:0009068)3.63896168
552-oxoglutarate metabolic process (GO:0006103)3.63109207
56fatty acid beta-oxidation (GO:0006635)3.62851966
57mitochondrial respiratory chain complex assembly (GO:0033108)3.61800033
58respiratory chain complex IV assembly (GO:0008535)3.61170849
59biotin metabolic process (GO:0006768)3.60996534
60negative regulation of ligase activity (GO:0051352)3.60300965
61negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.60300965
62histone exchange (GO:0043486)3.59831738
63heart process (GO:0003015)3.59800015
64heart contraction (GO:0060047)3.59800015
65cardiac muscle contraction (GO:0060048)3.54699666
66hydrogen ion transmembrane transport (GO:1902600)3.53217824
67branched-chain amino acid metabolic process (GO:0009081)3.51645751
68anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.50939969
69myofibril assembly (GO:0030239)3.50616155
70regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.47993270
71regulation of mitotic spindle checkpoint (GO:1903504)3.47993270
72regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.46970509
73termination of RNA polymerase III transcription (GO:0006386)3.46888636
74transcription elongation from RNA polymerase III promoter (GO:0006385)3.46888636
75cullin deneddylation (GO:0010388)3.45229700
76regulation of cellular amino acid metabolic process (GO:0006521)3.44965573
77regulation of mitochondrial translation (GO:0070129)3.37914227
78DNA double-strand break processing (GO:0000729)3.37534598
79cellular respiration (GO:0045333)3.36812924
80carnitine transmembrane transport (GO:1902603)3.36682337
81ribonucleoside triphosphate biosynthetic process (GO:0009201)3.36301284
82DNA damage response, detection of DNA damage (GO:0042769)3.35134675
83mitochondrial transport (GO:0006839)3.34170706
84purine nucleobase biosynthetic process (GO:0009113)3.33612230
85exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.30462400
86regulation of helicase activity (GO:0051095)3.29520210
87nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.27973622
88purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.26918264
89purine nucleoside monophosphate biosynthetic process (GO:0009127)3.26918264
90regulation of oxidative phosphorylation (GO:0002082)3.26189030
91establishment of viral latency (GO:0019043)3.25559656
92somatic diversification of immune receptors via somatic mutation (GO:0002566)3.24670706
93somatic hypermutation of immunoglobulin genes (GO:0016446)3.24670706
94regulation of cell communication by electrical coupling (GO:0010649)3.24389054
95cardiac muscle cell development (GO:0055013)3.24358620
96fatty acid catabolic process (GO:0009062)3.24350033
97DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.22375789
98cytochrome complex assembly (GO:0017004)3.22146522
99regulation of relaxation of muscle (GO:1901077)3.21339063
100signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.21129859
101signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.21129859
102signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.21129859
103protein deneddylation (GO:0000338)3.20524159
104rRNA modification (GO:0000154)3.20335760
105IMP biosynthetic process (GO:0006188)3.19114225
106ribosome assembly (GO:0042255)3.18713516
107intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.16050592
108signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.16050592
109amino-acid betaine transport (GO:0015838)3.15602861
110carnitine transport (GO:0015879)3.15602861
111tricarboxylic acid metabolic process (GO:0072350)3.15351023
112regulation of sarcomere organization (GO:0060297)3.14020001
113tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.12646480
114RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.12646480
115proton transport (GO:0015992)3.11436155
116DNA replication-independent nucleosome organization (GO:0034724)3.11147610
117DNA replication-independent nucleosome assembly (GO:0006336)3.11147610
118cardiac muscle tissue morphogenesis (GO:0055008)3.10470606
119positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.10229139
120hydrogen transport (GO:0006818)3.08318551
121DNA replication checkpoint (GO:0000076)3.08091369
122fatty acid oxidation (GO:0019395)3.06525162
123cellular ketone body metabolic process (GO:0046950)3.06423736
124generation of precursor metabolites and energy (GO:0006091)3.06134060
125nucleoside triphosphate biosynthetic process (GO:0009142)3.05730176
126signal transduction involved in DNA integrity checkpoint (GO:0072401)3.05615909
127signal transduction involved in DNA damage checkpoint (GO:0072422)3.05615909
128cardiac muscle hypertrophy (GO:0003300)3.04800391
129DNA ligation (GO:0006266)3.04800321
130pseudouridine synthesis (GO:0001522)3.04341044
131gluconeogenesis (GO:0006094)3.04183385
132ventricular cardiac muscle cell action potential (GO:0086005)3.03805918
133signal transduction involved in cell cycle checkpoint (GO:0072395)3.02268844
134lipid particle organization (GO:0034389)3.01152061
135* acetyl-CoA metabolic process (GO:0006084)3.00583657
136cardiac cell development (GO:0055006)3.00285660
137lipid oxidation (GO:0034440)2.99782039
138nucleobase biosynthetic process (GO:0046112)2.98845997
139regulation of cellular respiration (GO:0043457)2.98805142
140hexose biosynthetic process (GO:0019319)2.98742401
141ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.95745740
142positive regulation of ligase activity (GO:0051351)2.95695314
143spliceosomal snRNP assembly (GO:0000387)2.93727286
144regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.91497298
145water-soluble vitamin biosynthetic process (GO:0042364)2.91492323
146maturation of 5.8S rRNA (GO:0000460)2.90766967
147actin-mediated cell contraction (GO:0070252)2.90430901
148regulation of ubiquitin-protein transferase activity (GO:0051438)2.90058208
149mitotic metaphase plate congression (GO:0007080)2.89572501
150IMP metabolic process (GO:0046040)2.89061900
151L-serine metabolic process (GO:0006563)2.88591855
152peptidyl-histidine modification (GO:0018202)2.87552189
153somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.87509691
154isotype switching (GO:0045190)2.87509691
155somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.87509691
156striated muscle hypertrophy (GO:0014897)2.86628398
157DNA replication-dependent nucleosome assembly (GO:0006335)2.86142588
158DNA replication-dependent nucleosome organization (GO:0034723)2.86142588
159regulation of fatty acid oxidation (GO:0046320)2.85838445
160L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.85699264
161DNA strand elongation involved in DNA replication (GO:0006271)2.83977670
162negative regulation of DNA-dependent DNA replication (GO:2000104)2.83821987
163striated muscle contraction (GO:0006941)2.83535029
164protein targeting to mitochondrion (GO:0006626)2.82221991
165ribonucleoside monophosphate biosynthetic process (GO:0009156)2.81981854
166energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.81147103
167ATP hydrolysis coupled proton transport (GO:0015991)2.81147103
168DNA catabolic process, exonucleolytic (GO:0000738)2.80519174
169regulation of ligase activity (GO:0051340)2.78640232
170histone mRNA metabolic process (GO:0008334)2.74157689
171protein localization to kinetochore (GO:0034501)2.73876405
172telomere maintenance via semi-conservative replication (GO:0032201)2.72835633
173replication fork processing (GO:0031297)2.72774869
174lactate metabolic process (GO:0006089)2.70515510
175protein localization to mitochondrion (GO:0070585)2.68900436
176metaphase plate congression (GO:0051310)2.68704551
177DNA strand elongation (GO:0022616)2.65755884
178establishment of protein localization to mitochondrion (GO:0072655)2.64956900
179spindle checkpoint (GO:0031577)2.63771557

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.16756127
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.78229525
3* ESRRB_18555785_ChIP-Seq_MESCs_Mouse4.53640287
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.22831576
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.79905975
6E2F7_22180533_ChIP-Seq_HELA_Human3.60587071
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.57968856
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.47357999
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.40229622
10EST1_17652178_ChIP-ChIP_JURKAT_Human3.37947105
11* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.36144500
12ETS1_20019798_ChIP-Seq_JURKAT_Human3.24397555
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.97877781
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.97722874
15PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.94269367
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.70900956
17ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.68672763
18SRF_21415370_ChIP-Seq_HL-1_Mouse2.61656657
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.55347249
20THAP11_20581084_ChIP-Seq_MESCs_Mouse2.46257644
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.31047291
22YY1_21170310_ChIP-Seq_MESCs_Mouse2.28698420
23MYC_18555785_ChIP-Seq_MESCs_Mouse2.26785722
24SALL1_21062744_ChIP-ChIP_HESCs_Human2.18470872
25MYC_18358816_ChIP-ChIP_MESCs_Mouse2.13503047
26FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.03681912
27ZNF263_19887448_ChIP-Seq_K562_Human2.03663709
28E2F1_18555785_ChIP-Seq_MESCs_Mouse1.94732163
29PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.94560162
30ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.87320708
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.85443443
32DCP1A_22483619_ChIP-Seq_HELA_Human1.84180137
33FLI1_27457419_Chip-Seq_LIVER_Mouse1.79027953
34BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.78983418
35* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.77594413
36EWS_26573619_Chip-Seq_HEK293_Human1.76626404
37MYC_19030024_ChIP-ChIP_MESCs_Mouse1.74292569
38FUS_26573619_Chip-Seq_HEK293_Human1.73701091
39VDR_23849224_ChIP-Seq_CD4+_Human1.73616937
40MYC_18940864_ChIP-ChIP_HL60_Human1.60610178
41* GABP_19822575_ChIP-Seq_HepG2_Human1.58750137
42POU5F1_16153702_ChIP-ChIP_HESCs_Human1.57883161
43CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.55683505
44NELFA_20434984_ChIP-Seq_ESCs_Mouse1.53190480
45IGF1R_20145208_ChIP-Seq_DFB_Human1.50969772
46FOXP3_21729870_ChIP-Seq_TREG_Human1.50149886
47* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.49885141
48CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.49816315
49* NANOG_16153702_ChIP-ChIP_HESCs_Human1.49537662
50POU3F2_20337985_ChIP-ChIP_501MEL_Human1.45836539
51* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.44543703
52AR_21909140_ChIP-Seq_LNCAP_Human1.44102431
53FOXM1_23109430_ChIP-Seq_U2OS_Human1.42121277
54PCGF2_27294783_Chip-Seq_ESCs_Mouse1.39843785
55HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.39820594
56GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.36548696
57FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.34339442
58FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.34129491
59MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.33306564
60EP300_21415370_ChIP-Seq_HL-1_Mouse1.31498042
61* P300_19829295_ChIP-Seq_ESCs_Human1.31369792
62SOX2_16153702_ChIP-ChIP_HESCs_Human1.29923344
63RXR_22158963_ChIP-Seq_LIVER_Mouse1.28847202
64GATA4_21415370_ChIP-Seq_HL-1_Mouse1.28706166
65CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.25646857
66ZFP57_27257070_Chip-Seq_ESCs_Mouse1.24805233
67VDR_22108803_ChIP-Seq_LS180_Human1.23601482
68PADI4_21655091_ChIP-ChIP_MCF-7_Human1.22562661
69POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.22043486
70MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.21927412
71* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.21694216
72CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.20418089
73* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.19483854
74TAF15_26573619_Chip-Seq_HEK293_Human1.18182303
75SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.17588929
76SOX2_18555785_ChIP-Seq_MESCs_Mouse1.17115042
77E2F1_21310950_ChIP-Seq_MCF-7_Human1.16189298
78XRN2_22483619_ChIP-Seq_HELA_Human1.15767585
79SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.15546672
80ELF1_17652178_ChIP-ChIP_JURKAT_Human1.15122462
81HTT_18923047_ChIP-ChIP_STHdh_Human1.12736003
82MYC_19079543_ChIP-ChIP_MESCs_Mouse1.12591895
83NANOG_18555785_ChIP-Seq_MESCs_Mouse1.12411404
84PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.10888426
85PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.10288477
86FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.08674894
87CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.07881199
88ZNF274_21170338_ChIP-Seq_K562_Hela1.05669745
89ELK1_19687146_ChIP-ChIP_HELA_Human1.05285312
90NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.04032049
91CIITA_25753668_ChIP-Seq_RAJI_Human0.98878948
92CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.98787822
93STAT3_1855785_ChIP-Seq_MESCs_Mouse0.98640358
94POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.98400075
95EZH2_27294783_Chip-Seq_NPCs_Mouse0.95721231
96GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.95319769
97MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.94699986
98SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.94396713
99TBX5_21415370_ChIP-Seq_HL-1_Mouse0.93622855
100RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.93468820
101* MYCN_18555785_ChIP-Seq_MESCs_Mouse0.93334482
102POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.92609721
103MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.91373993
104GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90270941
105IRF1_19129219_ChIP-ChIP_H3396_Human0.90223746
106EZH2_22144423_ChIP-Seq_EOC_Human0.90200265
107EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.89970328
108NFE2_27457419_Chip-Seq_LIVER_Mouse0.89841219
109TP53_22573176_ChIP-Seq_HFKS_Human0.88237250
110* TTF2_22483619_ChIP-Seq_HELA_Human0.87930020
111SUZ12_27294783_Chip-Seq_NPCs_Mouse0.87301007
112NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.86345940
113PCGF2_27294783_Chip-Seq_NPCs_Mouse0.86189655
114REST_18959480_ChIP-ChIP_MESCs_Mouse0.85828101
115SOX2_19829295_ChIP-Seq_ESCs_Human0.85544475
116NANOG_19829295_ChIP-Seq_ESCs_Human0.85544475
117CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.85538316
118* HOXB4_20404135_ChIP-ChIP_EML_Mouse0.85249701
119CTBP2_25329375_ChIP-Seq_LNCAP_Human0.85226894
120REST_19997604_ChIP-ChIP_NEURONS_Mouse0.82602981
121TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82280760
122CTBP1_25329375_ChIP-Seq_LNCAP_Human0.82095957
123* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.79922883
124MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.77615631
125* SOX17_20123909_ChIP-Seq_XEN_Mouse0.76806720
126ELK1_22589737_ChIP-Seq_MCF10A_Human0.76357056
127EOMES_21245162_ChIP-Seq_HESCs_Human0.76184310
128CTCF_18555785_ChIP-Seq_MESCs_Mouse0.75992200
129YY1_22570637_ChIP-Seq_MALME-3M_Human0.75826845
130AUTS2_25519132_ChIP-Seq_293T-REX_Human0.75302459
131ERG_20517297_ChIP-Seq_VCAP_Human0.72006839
132GBX2_23144817_ChIP-Seq_PC3_Human0.70200073
133* LXR_22158963_ChIP-Seq_LIVER_Mouse0.70169368
134* TBX20_22080862_ChIP-Seq_HEART_Mouse0.69874473
135* TBX20_22328084_ChIP-Seq_HEART_Mouse0.69874473
136TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.68227038
137NCOR_22424771_ChIP-Seq_293T_Human0.67376473
138SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.67051728
139NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.66672881
140SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.66627610
141NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.65842157
142RBPJ_22232070_ChIP-Seq_NCS_Mouse0.65620154

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.76834342
2MP0003646_muscle_fatigue5.13658245
3MP0004084_abnormal_cardiac_muscle4.37102512
4MP0004215_abnormal_myocardial_fiber3.86555743
5MP0004036_abnormal_muscle_relaxation3.54115177
6MP0000751_myopathy3.45405052
7MP0006036_abnormal_mitochondrial_physio3.37850556
8MP0008058_abnormal_DNA_repair3.37818348
9MP0005330_cardiomyopathy3.15139049
10MP0000749_muscle_degeneration2.94593260
11MP0010094_abnormal_chromosome_stability2.89614602
12MP0003693_abnormal_embryo_hatching2.77196134
13MP0004957_abnormal_blastocyst_morpholog2.75159427
14MP0004130_abnormal_muscle_cell2.62175875
15MP0006035_abnormal_mitochondrial_morpho2.58432184
16MP0008877_abnormal_DNA_methylation2.50957338
17MP0002972_abnormal_cardiac_muscle2.39663006
18MP0002102_abnormal_ear_morphology2.34517730
19MP0003941_abnormal_skin_development2.29581150
20MP0003806_abnormal_nucleotide_metabolis2.28303318
21MP0003890_abnormal_embryonic-extraembry2.25799327
22MP0008775_abnormal_heart_ventricle2.24578310
23MP0003221_abnormal_cardiomyocyte_apopto2.20914853
24MP0001529_abnormal_vocalization2.20391341
25MP0005620_abnormal_muscle_contractility2.19106859
26MP0003137_abnormal_impulse_conducting2.18131996
27MP0006072_abnormal_retinal_apoptosis2.18055002
28MP0003111_abnormal_nucleus_morphology2.15713175
29MP0000372_irregular_coat_pigmentation2.08702522
30MP0008932_abnormal_embryonic_tissue2.08574390
31MP0002938_white_spotting2.06717232
32MP0004087_abnormal_muscle_fiber2.05529971
33MP0004145_abnormal_muscle_electrophysio1.98523971
34MP0006292_abnormal_olfactory_placode1.96685107
35MP0004484_altered_response_of1.96585363
36MP0002269_muscular_atrophy1.95750536
37MP0005670_abnormal_white_adipose1.95028110
38MP0005385_cardiovascular_system_phenoty1.94669630
39MP0001544_abnormal_cardiovascular_syste1.94669630
40MP0003077_abnormal_cell_cycle1.92561498
41MP0006138_congestive_heart_failure1.92048680
42MP0002332_abnormal_exercise_endurance1.86369011
43MP0002106_abnormal_muscle_physiology1.84179046
44MP0000750_abnormal_muscle_regeneration1.77525471
45MP0003136_yellow_coat_color1.72748281
46MP0000747_muscle_weakness1.72524547
47MP0004085_abnormal_heartbeat1.71886777
48MP0003880_abnormal_central_pattern1.68638484
49MP0001293_anophthalmia1.64587925
50MP0004133_heterotaxia1.64573968
51MP0004233_abnormal_muscle_weight1.56210488
52MP0010030_abnormal_orbit_morphology1.55136498
53MP0008007_abnormal_cellular_replicative1.55072855
54MP0000013_abnormal_adipose_tissue1.52912331
55MP0008057_abnormal_DNA_replication1.50373540
56MP0004147_increased_porphyrin_level1.49277697
57MP0010630_abnormal_cardiac_muscle1.47840856
58MP0002127_abnormal_cardiovascular_syste1.46823328
59MP0004043_abnormal_pH_regulation1.45910240
60MP0005369_muscle_phenotype1.45480700
61MP0003786_premature_aging1.43701867
62MP0005253_abnormal_eye_physiology1.43407928
63MP0002254_reproductive_system_inflammat1.42686465
64MP0005266_abnormal_metabolism1.42546033
65MP0005332_abnormal_amino_acid1.42374559
66MP0005085_abnormal_gallbladder_physiolo1.38956204
67MP0003119_abnormal_digestive_system1.38540511
68MP0000759_abnormal_skeletal_muscle1.38530546
69MP0005084_abnormal_gallbladder_morpholo1.38413268
70MP0005666_abnormal_adipose_tissue1.37491381
71MP0003195_calcinosis1.33490340
72MP0002139_abnormal_hepatobiliary_system1.32961920
73MP0003937_abnormal_limbs/digits/tail_de1.32295680
74MP0006276_abnormal_autonomic_nervous1.28450666
75MP0008789_abnormal_olfactory_epithelium1.27433873
76MP0005535_abnormal_body_temperature1.26902281
77MP0003011_delayed_dark_adaptation1.24015074
78MP0003121_genomic_imprinting1.20505248
79MP0002090_abnormal_vision1.18543253
80MP0000516_abnormal_urinary_system1.18355072
81MP0005367_renal/urinary_system_phenotyp1.18355072
82MP0005365_abnormal_bile_salt1.14342332
83MP0005551_abnormal_eye_electrophysiolog1.13596320
84MP0002638_abnormal_pupillary_reflex1.12787272
85MP0009046_muscle_twitch1.08657844
86MP0001485_abnormal_pinna_reflex1.06914600
87MP0001730_embryonic_growth_arrest1.06646600
88MP0002876_abnormal_thyroid_physiology1.03806146
89MP0002971_abnormal_brown_adipose1.02684657
90MP0004924_abnormal_behavior1.00533768
91MP0005386_behavior/neurological_phenoty1.00533768
92MP0001984_abnormal_olfaction1.00336612
93MP0005584_abnormal_enzyme/coenzyme_acti0.98900438
94MP0005360_urolithiasis0.97629845
95MP0009672_abnormal_birth_weight0.96742658
96MP0005187_abnormal_penis_morphology0.94612943
97MP0002084_abnormal_developmental_patter0.93777350
98MP0001764_abnormal_homeostasis0.93761059
99MP0005499_abnormal_olfactory_system0.93212326
100MP0005394_taste/olfaction_phenotype0.93212326
101MP0000230_abnormal_systemic_arterial0.93037809
102MP0008875_abnormal_xenobiotic_pharmacok0.92574775
103MP0004142_abnormal_muscle_tone0.92313237
104MP0002233_abnormal_nose_morphology0.92146637
105MP0010329_abnormal_lipoprotein_level0.91780103
106MP0001905_abnormal_dopamine_level0.91724478
107MP0001188_hyperpigmentation0.91387026
108MP0002272_abnormal_nervous_system0.91025433
109MP0005319_abnormal_enzyme/_coenzyme0.90992224
110MP0003186_abnormal_redox_activity0.90509117
111MP0002118_abnormal_lipid_homeostasis0.90042022
112MP0002085_abnormal_embryonic_tissue0.89511854
113MP0002078_abnormal_glucose_homeostasis0.88880983
114MP0003787_abnormal_imprinting0.88645158
115MP0001299_abnormal_eye_distance/0.88345069
116MP0005380_embryogenesis_phenotype0.86694446
117MP0001672_abnormal_embryogenesis/_devel0.86694446
118MP0001697_abnormal_embryo_size0.86476376
119MP0003567_abnormal_fetal_cardiomyocyte0.86122106
120MP0002751_abnormal_autonomic_nervous0.85726652
121MP0005375_adipose_tissue_phenotype0.83188610
122MP0009697_abnormal_copulation0.83135453
123MP0003950_abnormal_plasma_membrane0.82932409
124MP0001286_abnormal_eye_development0.82170053
125MP0003329_amyloid_beta_deposits0.81876886
126MP0005451_abnormal_body_composition0.81797254
127MP0001440_abnormal_grooming_behavior0.79867984
128MP0003828_pulmonary_edema0.79847400
129MP0001661_extended_life_span0.79389155
130MP0008995_early_reproductive_senescence0.79329105
131MP0001727_abnormal_embryo_implantation0.78913207
132MP0006054_spinal_hemorrhage0.78549483
133MP0002064_seizures0.77624143
134MP0002210_abnormal_sex_determination0.77578189
135MP0002909_abnormal_adrenal_gland0.77261478
136MP0001929_abnormal_gametogenesis0.76985390
137MP0005408_hypopigmentation0.76459625
138MP0002736_abnormal_nociception_after0.75846761
139MP0000358_abnormal_cell_content/0.75806384
140MP0005376_homeostasis/metabolism_phenot0.74596555
141MP0005391_vision/eye_phenotype0.73335209
142MP0003718_maternal_effect0.73202586
143MP0005395_other_phenotype0.72732157
144MP0009745_abnormal_behavioral_response0.72602336
145MP0000653_abnormal_sex_gland0.72282143
146MP0005075_abnormal_melanosome_morpholog0.72192373
147MP0002735_abnormal_chemical_nociception0.72154121
148MP0002822_catalepsy0.70658463
149MP0000647_abnormal_sebaceous_gland0.69978188
150MP0001145_abnormal_male_reproductive0.68439536
151MP0008260_abnormal_autophagy0.68207306
152MP0003635_abnormal_synaptic_transmissio0.66438659
153MP0005452_abnormal_adipose_tissue0.63521623
154MP0004185_abnormal_adipocyte_glucose0.63490081
155MP0003122_maternal_imprinting0.63187602
156MP0000003_abnormal_adipose_tissue0.62516929
157MP0004270_analgesia0.62363202
158MP0002067_abnormal_sensory_capabilities0.62290933
159MP0003656_abnormal_erythrocyte_physiolo0.60505178
160MP0008872_abnormal_physiological_respon0.58865981
161MP0000343_altered_response_to0.57829974
162MP0001968_abnormal_touch/_nociception0.56836228
163MP0003123_paternal_imprinting0.56585218

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.72755659
2Abnormal mitochondria in muscle tissue (HP:0008316)5.63700061
3Hepatic necrosis (HP:0002605)5.15963698
4Acute encephalopathy (HP:0006846)5.07965210
5Increased serum pyruvate (HP:0003542)4.92775741
6Abnormality of glycolysis (HP:0004366)4.92775741
7Mitochondrial inheritance (HP:0001427)4.87334908
8Hepatocellular necrosis (HP:0001404)4.85473203
9Progressive macrocephaly (HP:0004481)4.74546091
10Increased CSF lactate (HP:0002490)4.67932030
11Sudden death (HP:0001699)4.35689716
12Myoglobinuria (HP:0002913)4.29340932
13Cerebral edema (HP:0002181)4.29160065
14Abnormality of alanine metabolism (HP:0010916)4.06761504
15Hyperalaninemia (HP:0003348)4.06761504
16Abnormality of pyruvate family amino acid metabolism (HP:0010915)4.06761504
17* Lactic acidosis (HP:0003128)3.92851774
18Exercise-induced myalgia (HP:0003738)3.90708397
19Increased muscle lipid content (HP:0009058)3.84618117
20Palpitations (HP:0001962)3.77168796
21Rhabdomyolysis (HP:0003201)3.70663391
22Exercise-induced muscle cramps (HP:0003710)3.65031492
23Increased intramyocellular lipid droplets (HP:0012240)3.56815220
24Exercise intolerance (HP:0003546)3.54361778
25Pheochromocytoma (HP:0002666)3.50618008
26Calf muscle hypertrophy (HP:0008981)3.50188931
27Dicarboxylic aciduria (HP:0003215)3.48404441
28Abnormality of dicarboxylic acid metabolism (HP:0010995)3.48404441
29Respiratory failure (HP:0002878)3.46793022
30Neuroendocrine neoplasm (HP:0100634)3.40705152
31Decreased activity of mitochondrial respiratory chain (HP:0008972)3.39755653
32Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.39755653
33Lipid accumulation in hepatocytes (HP:0006561)3.38082972
34Abnormality of fatty-acid metabolism (HP:0004359)3.37330410
35Increased serum lactate (HP:0002151)3.34152546
36Muscle hypertrophy of the lower extremities (HP:0008968)3.28792255
37Hypoglycemic coma (HP:0001325)3.26942407
38Ventricular tachycardia (HP:0004756)3.18159181
39Hyperglycinuria (HP:0003108)3.12773735
40Ragged-red muscle fibers (HP:0003200)3.11520496
41Ketoacidosis (HP:0001993)3.11026815
42Colon cancer (HP:0003003)3.10998091
43Abnormality of the labia minora (HP:0012880)3.07365687
44Increased hepatocellular lipid droplets (HP:0006565)3.05543611
45Muscle fiber splitting (HP:0003555)3.00451357
46Lethargy (HP:0001254)2.99906899
47Atrial fibrillation (HP:0005110)2.93915270
48Lipoatrophy (HP:0100578)2.83187201
49CNS demyelination (HP:0007305)2.78480150
50Syncope (HP:0001279)2.78270383
51Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.77149032
52Abnormality of glycine metabolism (HP:0010895)2.76913356
53Abnormality of serine family amino acid metabolism (HP:0010894)2.76913356
54Generalized aminoaciduria (HP:0002909)2.74165127
55Optic disc pallor (HP:0000543)2.73995828
56Primary atrial arrhythmia (HP:0001692)2.73749055
57Leukodystrophy (HP:0002415)2.71878639
58Supraventricular tachycardia (HP:0004755)2.70942962
59Abnormality of methionine metabolism (HP:0010901)2.68859437
60Type I transferrin isoform profile (HP:0003642)2.67660622
61Ketosis (HP:0001946)2.64522551
62Supraventricular arrhythmia (HP:0005115)2.61935290
63Abnormality of the calf musculature (HP:0001430)2.61839384
64Hyperammonemia (HP:0001987)2.61722481
65Nemaline bodies (HP:0003798)2.56267512
66Hyperglycinemia (HP:0002154)2.55218819
67Methylmalonic aciduria (HP:0012120)2.55092456
68Dilated cardiomyopathy (HP:0001644)2.50817226
69Abnormality of aspartate family amino acid metabolism (HP:0010899)2.49725297
70Conjunctival hamartoma (HP:0100780)2.48273766
71Neoplasm of the adrenal gland (HP:0100631)2.43929097
72Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.40105439
73Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.39956770
74Hyperinsulinemic hypoglycemia (HP:0000825)2.37443956
75Abnormal protein glycosylation (HP:0012346)2.34099006
76Abnormal glycosylation (HP:0012345)2.34099006
77Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.34099006
78Abnormal protein N-linked glycosylation (HP:0012347)2.34099006
79Proximal tubulopathy (HP:0000114)2.33496596
80Reduced antithrombin III activity (HP:0001976)2.31130600
81Emotional lability (HP:0000712)2.30853092
82Meckel diverticulum (HP:0002245)2.29861611
83Muscle fiber inclusion bodies (HP:0100299)2.29382596
84Abnormality of serum amino acid levels (HP:0003112)2.28701270
85Vomiting (HP:0002013)2.27601511
86Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.27346623
87Metabolic acidosis (HP:0001942)2.25174039
88Nausea (HP:0002018)2.24311178
89Bundle branch block (HP:0011710)2.23361768
90Renal Fanconi syndrome (HP:0001994)2.23251066
91Hypoglycemic seizures (HP:0002173)2.22921564
92Ventricular arrhythmia (HP:0004308)2.22854490
93Myotonia (HP:0002486)2.22626094
94Athetosis (HP:0002305)2.20913822
953-Methylglutaconic aciduria (HP:0003535)2.19526757
96Neoplasm of head and neck (HP:0012288)2.17923384
97Esophageal neoplasm (HP:0100751)2.17923384
98Bifid tongue (HP:0010297)2.16395619
99Respiratory difficulties (HP:0002880)2.16128917
100Abnormality of the ileum (HP:0001549)2.15768169
101Hyporeflexia of lower limbs (HP:0002600)2.15193409
102EMG: myopathic abnormalities (HP:0003458)2.15155584
103Glycosuria (HP:0003076)2.13242795
104Abnormality of urine glucose concentration (HP:0011016)2.13242795
105Ependymoma (HP:0002888)2.13230925
106Left ventricular hypertrophy (HP:0001712)2.11358407
107Muscle stiffness (HP:0003552)2.09052085
108Prolonged QT interval (HP:0001657)2.06759250
109Exertional dyspnea (HP:0002875)2.05271360
110Pancreatic cysts (HP:0001737)2.03722616
111Progressive external ophthalmoplegia (HP:0000590)2.03713731
112Methylmalonic acidemia (HP:0002912)2.03580835
113Gout (HP:0001997)2.02680600
114Gliosis (HP:0002171)2.01944055
115X-linked dominant inheritance (HP:0001423)2.01800340
116Abnormal lung lobation (HP:0002101)2.01387046
117Subaortic stenosis (HP:0001682)2.00471613
118Abnormality of the left ventricular outflow tract (HP:0011103)2.00471613
119Atrioventricular block (HP:0001678)1.99815896
120Oligomenorrhea (HP:0000876)1.99720374
121Right ventricular cardiomyopathy (HP:0011663)1.99179923
122Pancreatic islet-cell hyperplasia (HP:0004510)1.97370680
123Ventricular fibrillation (HP:0001663)1.96511136
124Aplasia/Hypoplasia of the uvula (HP:0010293)1.96433682
125Microvesicular hepatic steatosis (HP:0001414)1.95479390
126Septo-optic dysplasia (HP:0100842)1.86968887
127Intestinal atresia (HP:0011100)1.83370059
128Pancreatic fibrosis (HP:0100732)1.80706506
129Chromosomal breakage induced by crosslinking agents (HP:0003221)1.80096306
130Aplasia/Hypoplasia involving the musculature (HP:0001460)1.78617993
131Degeneration of anterior horn cells (HP:0002398)1.77443925
132Abnormality of the anterior horn cell (HP:0006802)1.77443925
133Abnormality of chromosome stability (HP:0003220)1.75948912
134Supernumerary spleens (HP:0009799)1.74943603
135Megaloblastic anemia (HP:0001889)1.68991446
136Abnormality of vitamin B metabolism (HP:0004340)1.67919512
137Type 2 muscle fiber atrophy (HP:0003554)1.67683773
138Chromsome breakage (HP:0040012)1.67109624
139Multiple enchondromatosis (HP:0005701)1.66762458
140Absent septum pellucidum (HP:0001331)1.65745717
141Abnormality of the vitamin B12 metabolism (HP:0004341)1.64729087
142Abnormality of the septum pellucidum (HP:0007375)1.63262556
143Glioma (HP:0009733)1.62621156
144Abnormality of the preputium (HP:0100587)1.62345105
145Cerebral hypomyelination (HP:0006808)1.61990482
146Bilateral microphthalmos (HP:0007633)1.61659346
147Abnormality of midbrain morphology (HP:0002418)1.61631609
148Molar tooth sign on MRI (HP:0002419)1.61631609
149Horseshoe kidney (HP:0000085)1.61228601
150Congenital, generalized hypertrichosis (HP:0004540)1.61179234
151Amniotic constriction ring (HP:0009775)1.60859254

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK35.22412467
2PDK45.22412467
3BCKDK4.14279730
4OBSCN3.68787532
5VRK23.46628789
6NEK13.40992975
7PDK23.28068786
8MYLK2.97742438
9MST42.67423317
10PBK2.59129756
11BUB12.56923045
12PHKG12.46079133
13PHKG22.46079133
14NME12.34316521
15CDC72.19256244
16MKNK22.19194831
17TRIM282.16874244
18NUAK12.13217758
19TSSK62.01879748
20PINK11.98033200
21MKNK11.91492089
22STK241.88055286
23STK161.85829422
24TAF11.82414509
25LMTK21.82004211
26TNIK1.81795293
27TTN1.79902565
28MAP4K21.78028321
29BMPR1B1.75764363
30MAP3K121.73746211
31EIF2AK11.70939595
32ACVR1B1.66601015
33WEE11.62111579
34GRK71.61730586
35CCNB11.55927365
36STK38L1.46291873
37ARAF1.44875033
38FRK1.38568705
39PNCK1.38182458
40MUSK1.33975062
41ZAK1.31409941
42MAP3K41.30286631
43MAP2K41.28118653
44AKT31.23716426
45ERBB41.21981817
46MAP2K71.18941705
47WNK41.11910755
48EIF2AK31.10722547
49GRK51.09397245
50CSNK1G11.04433594
51GRK11.04315189
52CAMK2D1.04061344
53NME21.03986822
54WNK30.99007750
55CSNK1G20.98198700
56CASK0.97723146
57PIK3CA0.96837648
58ERBB30.95976195
59PLK20.95776765
60TIE10.92175808
61CSNK1G30.90962189
62BCR0.84440378
63STK390.82706242
64PAK30.80420482
65BRAF0.80321233
66ATR0.79584265
67EIF2AK20.78509129
68AURKB0.75728333
69NTRK30.75688366
70PASK0.74736456
71CAMK2A0.73390429
72STK40.73264029
73MINK10.72845178
74CAMK2G0.69459238
75PLK40.68862378
76ILK0.68387481
77PRKAA10.67662469
78BRSK20.67473740
79MAPK120.66225426
80NEK20.65551175
81CSNK1A1L0.63944386
82PKN20.62470855
83PRKCG0.58681338
84MAP3K50.58221288
85BRSK10.58163693
86TESK20.57996297
87PLK30.57236588
88CHEK20.56962342
89DYRK30.56717450
90ATM0.56456952
91OXSR10.56172940
92RPS6KA40.55905243
93PRKACA0.55256345
94LIMK10.54475804
95FGFR10.53830379
96STK30.52914602
97TLK10.52881892
98MAPKAPK30.51779801
99ALK0.51338802
100EPHA40.50492616
101INSRR0.48334330
102TGFBR10.48180395
103PRKAA20.47301828
104CAMK2B0.47241958
105PIK3CG0.46768470
106KDR0.45817516
107PAK40.43464786
108CHEK10.43386457
109AURKA0.42869506
110PRKACB0.42751741
111DAPK30.42514811
112PRKACG0.41748058
113FLT30.40696005
114CAMK10.38010254
115DAPK10.37878805
116CSNK1E0.37746363
117PRKCE0.36556083
118MAPK130.33776065
119PTK2B0.33747438
120ADRBK10.32678908
121ABL20.31721319
122PLK10.31273293
123CLK10.30310916
124MARK10.30281918
125SRPK10.30055050
126NLK0.30025187
127MAP2K10.29454565
128ADRBK20.29400517
129TTK0.29336359
130FGFR20.28996421
131MAP2K60.26309037
132CDK190.26256618
133MAP3K110.25532473
134KSR10.23692904
135DYRK20.22686064
136SGK2230.22329419
137SGK4940.22329419
138AKT20.22175422
139CSNK2A20.21619794
140CSNK2A10.21503952
141LATS20.21448817
142VRK10.21060493
143STK380.20030737
144SIK30.19291092
145CDK140.17943565

Predicted pathways (KEGG)

RankGene SetZ-score
1* Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.68048221
2Oxidative phosphorylation_Homo sapiens_hsa001904.34215596
3Parkinsons disease_Homo sapiens_hsa050123.94701658
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.90256416
5Propanoate metabolism_Homo sapiens_hsa006403.45268307
6Alzheimers disease_Homo sapiens_hsa050102.79889531
7Cardiac muscle contraction_Homo sapiens_hsa042602.73006142
8Huntingtons disease_Homo sapiens_hsa050162.70439340
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.65510980
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.59440423
11* Carbon metabolism_Homo sapiens_hsa012002.59024224
12* Pyruvate metabolism_Homo sapiens_hsa006202.54308499
13Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.42374330
14Fatty acid degradation_Homo sapiens_hsa000712.41510131
15DNA replication_Homo sapiens_hsa030302.38705122
16Proteasome_Homo sapiens_hsa030502.37894115
17Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.32055830
18Fatty acid metabolism_Homo sapiens_hsa012122.20748174
19Non-homologous end-joining_Homo sapiens_hsa034502.16589365
20Homologous recombination_Homo sapiens_hsa034402.01719166
21Fatty acid elongation_Homo sapiens_hsa000621.95892973
22Butanoate metabolism_Homo sapiens_hsa006501.88370103
23One carbon pool by folate_Homo sapiens_hsa006701.76938651
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.65093817
25Base excision repair_Homo sapiens_hsa034101.64673963
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.64116158
27RNA degradation_Homo sapiens_hsa030181.64081370
28Biosynthesis of amino acids_Homo sapiens_hsa012301.60232955
29Basal transcription factors_Homo sapiens_hsa030221.54952449
30Spliceosome_Homo sapiens_hsa030401.54434123
31Nucleotide excision repair_Homo sapiens_hsa034201.51662258
32Fanconi anemia pathway_Homo sapiens_hsa034601.45551505
33* Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.31917933
34Steroid biosynthesis_Homo sapiens_hsa001001.28426897
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.19178345
36Vitamin B6 metabolism_Homo sapiens_hsa007501.19177876
37Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.18655575
38Peroxisome_Homo sapiens_hsa041461.12865202
39Collecting duct acid secretion_Homo sapiens_hsa049661.12572273
40beta-Alanine metabolism_Homo sapiens_hsa004101.11380055
41PPAR signaling pathway_Homo sapiens_hsa033201.08131039
42Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.07385858
43RNA polymerase_Homo sapiens_hsa030201.07253778
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.00773657
45Cell cycle_Homo sapiens_hsa041100.98662748
46Fructose and mannose metabolism_Homo sapiens_hsa000510.97678000
47Fatty acid biosynthesis_Homo sapiens_hsa000610.89796585
48Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.87950256
49Dilated cardiomyopathy_Homo sapiens_hsa054140.87903533
50Tryptophan metabolism_Homo sapiens_hsa003800.87224012
51Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.85132294
52Phenylalanine metabolism_Homo sapiens_hsa003600.84688509
53* Metabolic pathways_Homo sapiens_hsa011000.84283422
54Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.80657457
55Pentose phosphate pathway_Homo sapiens_hsa000300.80204569
56Nitrogen metabolism_Homo sapiens_hsa009100.74577384
57Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.73370033
58Sulfur metabolism_Homo sapiens_hsa009200.71431295
59Tyrosine metabolism_Homo sapiens_hsa003500.68724677
60Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.67366967
61Protein export_Homo sapiens_hsa030600.65947213
62Galactose metabolism_Homo sapiens_hsa000520.64960571
63Arginine biosynthesis_Homo sapiens_hsa002200.64895287
64Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.64816653
65Regulation of autophagy_Homo sapiens_hsa041400.63472355
66mRNA surveillance pathway_Homo sapiens_hsa030150.57831709
67Arginine and proline metabolism_Homo sapiens_hsa003300.55191489
68* Glucagon signaling pathway_Homo sapiens_hsa049220.54640418
69Starch and sucrose metabolism_Homo sapiens_hsa005000.54539158
70Synaptic vesicle cycle_Homo sapiens_hsa047210.53324941
71Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.52526875
72Glycerolipid metabolism_Homo sapiens_hsa005610.51696050
73Primary bile acid biosynthesis_Homo sapiens_hsa001200.51328383
74Maturity onset diabetes of the young_Homo sapiens_hsa049500.51271395
75Vibrio cholerae infection_Homo sapiens_hsa051100.50793342
76Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.50439676
77Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.49859527
78Retinol metabolism_Homo sapiens_hsa008300.49294305
79Vitamin digestion and absorption_Homo sapiens_hsa049770.48433836
80Pyrimidine metabolism_Homo sapiens_hsa002400.48143424
81p53 signaling pathway_Homo sapiens_hsa041150.47056869
82Folate biosynthesis_Homo sapiens_hsa007900.46871897
83Purine metabolism_Homo sapiens_hsa002300.46198084
84Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.42851337
85Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42490160
86Nicotine addiction_Homo sapiens_hsa050330.42144877
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39252159
88Glutathione metabolism_Homo sapiens_hsa004800.39141423
89Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.36336298
90N-Glycan biosynthesis_Homo sapiens_hsa005100.35496135
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.35350691
92Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.34987421
93Insulin signaling pathway_Homo sapiens_hsa049100.33369845
94TGF-beta signaling pathway_Homo sapiens_hsa043500.31534312
95Calcium signaling pathway_Homo sapiens_hsa040200.31474308
96Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.31337280
97Ribosome_Homo sapiens_hsa030100.30500823
98Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.29947913
99AMPK signaling pathway_Homo sapiens_hsa041520.29798890
100Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.28660274
101GABAergic synapse_Homo sapiens_hsa047270.28288175
102Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.28013572
103Glycerophospholipid metabolism_Homo sapiens_hsa005640.27560861
104Basal cell carcinoma_Homo sapiens_hsa052170.27408644
105Linoleic acid metabolism_Homo sapiens_hsa005910.27164375
106Fat digestion and absorption_Homo sapiens_hsa049750.26557868
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.26256616
108Steroid hormone biosynthesis_Homo sapiens_hsa001400.25953449
109Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.25734489
110RNA transport_Homo sapiens_hsa030130.25181360
111Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.24700792
112Oocyte meiosis_Homo sapiens_hsa041140.20394539
113Sulfur relay system_Homo sapiens_hsa041220.19444376
114Pentose and glucuronate interconversions_Homo sapiens_hsa000400.19256889
115Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.18928067
116Olfactory transduction_Homo sapiens_hsa047400.18878884
117Wnt signaling pathway_Homo sapiens_hsa043100.18267565
118Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.18157341
119Lysine degradation_Homo sapiens_hsa003100.17203202
120Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.17042752
121cGMP-PKG signaling pathway_Homo sapiens_hsa040220.15713616
122Taste transduction_Homo sapiens_hsa047420.15408630
123Phototransduction_Homo sapiens_hsa047440.15271121
124Circadian entrainment_Homo sapiens_hsa047130.14174387
125Caffeine metabolism_Homo sapiens_hsa002320.13289443
126Circadian rhythm_Homo sapiens_hsa047100.11535935
127Insulin resistance_Homo sapiens_hsa049310.11319250
128Selenocompound metabolism_Homo sapiens_hsa004500.11114114
129Dopaminergic synapse_Homo sapiens_hsa047280.09348140
130Chemical carcinogenesis_Homo sapiens_hsa052040.08747072
131Renin secretion_Homo sapiens_hsa049240.08653121
132Mismatch repair_Homo sapiens_hsa034300.08100956

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