PDE8A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE8 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.87188942
2L-phenylalanine catabolic process (GO:0006559)5.87188942
3L-phenylalanine metabolic process (GO:0006558)5.22810758
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.22810758
5fusion of sperm to egg plasma membrane (GO:0007342)5.13424848
6cilium or flagellum-dependent cell motility (GO:0001539)4.91276046
7sperm motility (GO:0030317)4.61836269
8aromatic amino acid family catabolic process (GO:0009074)4.34099337
9central nervous system myelination (GO:0022010)4.30903505
10axon ensheathment in central nervous system (GO:0032291)4.30903505
11piRNA metabolic process (GO:0034587)4.06734700
12multicellular organism reproduction (GO:0032504)4.06398275
13alpha-linolenic acid metabolic process (GO:0036109)3.99009825
14fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.94237484
15acrosome reaction (GO:0007340)3.91764839
16plasma membrane fusion (GO:0045026)3.79071511
17plasma lipoprotein particle clearance (GO:0034381)3.67062073
18bile acid biosynthetic process (GO:0006699)3.60178028
19protein carboxylation (GO:0018214)3.47009776
20peptidyl-glutamic acid carboxylation (GO:0017187)3.47009776
21reproduction (GO:0000003)3.45389683
22negative regulation of fatty acid transport (GO:2000192)3.43036660
23low-density lipoprotein particle clearance (GO:0034383)3.41500745
24sperm capacitation (GO:0048240)3.36706571
25sperm-egg recognition (GO:0035036)3.35139268
26drug transmembrane transport (GO:0006855)3.31219089
27fatty acid elongation (GO:0030497)3.29980323
28organic cation transport (GO:0015695)3.29799170
29bile acid metabolic process (GO:0008206)3.28917995
30negative regulation of inclusion body assembly (GO:0090084)3.28897146
31acrosome assembly (GO:0001675)3.28757444
32positive regulation of extracellular matrix organization (GO:1903055)3.26167980
33glyoxylate metabolic process (GO:0046487)3.26053590
34axonemal dynein complex assembly (GO:0070286)3.25092555
35response to mercury ion (GO:0046689)3.22684638
36cysteine metabolic process (GO:0006534)3.22606344
37triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.19673366
38aspartate family amino acid catabolic process (GO:0009068)3.19263590
39negative regulation of lipase activity (GO:0060192)3.19241264
40male meiosis (GO:0007140)3.18447462
41cholesterol efflux (GO:0033344)3.18212243
42regulation of complement activation (GO:0030449)3.18029100
43urea cycle (GO:0000050)3.15761469
44urea metabolic process (GO:0019627)3.15761469
45coenzyme catabolic process (GO:0009109)3.15513079
46regulation of triglyceride catabolic process (GO:0010896)3.14286151
47complement activation, alternative pathway (GO:0006957)3.13936336
48macroautophagy (GO:0016236)3.12827994
49cell adhesion mediated by integrin (GO:0033627)3.10415435
50myelin maintenance (GO:0043217)3.09138224
51cell-cell recognition (GO:0009988)3.08193288
52tyrosine metabolic process (GO:0006570)3.06497673
53sulfur amino acid catabolic process (GO:0000098)3.05864358
54cofactor catabolic process (GO:0051187)3.03473849
55acylglycerol homeostasis (GO:0055090)3.01901379
56triglyceride homeostasis (GO:0070328)3.01901379
57synaptonemal complex organization (GO:0070193)3.00203526
58spermatid development (GO:0007286)2.99225895
59epithelial cilium movement (GO:0003351)2.98747730
60positive regulation of endothelial cell apoptotic process (GO:2000353)2.98007355
61carnitine transport (GO:0015879)2.97925208
62amino-acid betaine transport (GO:0015838)2.97925208
63very-low-density lipoprotein particle assembly (GO:0034379)2.95703624
64cell wall macromolecule metabolic process (GO:0044036)2.95123385
65cell wall macromolecule catabolic process (GO:0016998)2.95123385
66positive regulation of triglyceride lipase activity (GO:0061365)2.94363931
67positive regulation of lipoprotein lipase activity (GO:0051006)2.94363931
68aromatic amino acid family metabolic process (GO:0009072)2.92540138
69indole-containing compound catabolic process (GO:0042436)2.91972098
70indolalkylamine catabolic process (GO:0046218)2.91972098
71tryptophan catabolic process (GO:0006569)2.91972098
72creatine metabolic process (GO:0006600)2.90860589
73plasma lipoprotein particle remodeling (GO:0034369)2.90408979
74protein-lipid complex remodeling (GO:0034368)2.90408979
75macromolecular complex remodeling (GO:0034367)2.90408979
76nitrogen cycle metabolic process (GO:0071941)2.90176848
77short-chain fatty acid metabolic process (GO:0046459)2.89478227
78regulation of lipoprotein metabolic process (GO:0050746)2.88953687
79amino-acid betaine metabolic process (GO:0006577)2.88308571
80protein localization to endosome (GO:0036010)2.87460228
81cellular response to ethanol (GO:0071361)2.86621768
82reverse cholesterol transport (GO:0043691)2.84223394
83carnitine transmembrane transport (GO:1902603)2.84036307
84response to methylmercury (GO:0051597)2.83784326
85positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.83664916
86fatty acid beta-oxidation (GO:0006635)2.83559582
87tryptophan metabolic process (GO:0006568)2.82751756
88negative regulation of fibrinolysis (GO:0051918)2.82516346
89binding of sperm to zona pellucida (GO:0007339)2.81424678
90positive regulation of smooth muscle cell migration (GO:0014911)2.80328010
91negative regulation of protein activation cascade (GO:2000258)2.79299972
92synaptonemal complex assembly (GO:0007130)2.79117773
93bile acid and bile salt transport (GO:0015721)2.77615795
94regulation of membrane protein ectodomain proteolysis (GO:0051043)2.77590246
95regulation of cholesterol homeostasis (GO:2000188)2.77559827
96oligosaccharide catabolic process (GO:0009313)2.76341705
97fatty-acyl-CoA biosynthetic process (GO:0046949)2.75028521
98positive regulation of glycolytic process (GO:0045821)2.74785037
99kynurenine metabolic process (GO:0070189)2.72755646
100epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.71876347
101homocysteine metabolic process (GO:0050667)2.71506123
102intestinal absorption (GO:0050892)2.71442638
103negative regulation of complement activation (GO:0045916)2.71202576
104regulation of protein activation cascade (GO:2000257)2.70964305
105high-density lipoprotein particle remodeling (GO:0034375)2.70666078
106fatty acid oxidation (GO:0019395)2.69162083
107peptidyl-glutamic acid modification (GO:0018200)2.68151276
108fatty acid catabolic process (GO:0009062)2.67766876
109retina vasculature morphogenesis in camera-type eye (GO:0061299)2.67543942
110protein-lipid complex assembly (GO:0065005)2.67094904
111lysine catabolic process (GO:0006554)2.66142596
112lysine metabolic process (GO:0006553)2.66142596
113very long-chain fatty acid metabolic process (GO:0000038)2.66006188
114heme transport (GO:0015886)2.65637752
115long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.65532495
116regulation of sequestering of triglyceride (GO:0010889)2.65264975
117positive regulation of lipid catabolic process (GO:0050996)2.65077013
118single fertilization (GO:0007338)2.64898202
119sterol homeostasis (GO:0055092)2.64430227
120regulation of cholesterol storage (GO:0010885)2.64004441
121cholesterol homeostasis (GO:0042632)2.63518706
122alpha-amino acid catabolic process (GO:1901606)2.63022500
123lipid oxidation (GO:0034440)2.62727470
124protein-lipid complex subunit organization (GO:0071825)2.62465264
125negative regulation of fatty acid biosynthetic process (GO:0045717)2.61951362
126regulation of fibrinolysis (GO:0051917)2.61132035
127epoxygenase P450 pathway (GO:0019373)2.60881795
128acetyl-CoA metabolic process (GO:0006084)2.60065320
129glomerular filtration (GO:0003094)2.59803707
130renal filtration (GO:0097205)2.57261137
131phospholipid efflux (GO:0033700)2.56574769
132lipoprotein metabolic process (GO:0042157)2.56407532
133negative regulation of lipid transport (GO:0032369)2.55563144
134basement membrane organization (GO:0071711)2.55178076
135positive regulation of steroid metabolic process (GO:0045940)2.50991352
136plasma lipoprotein particle organization (GO:0071827)2.49567100
137retinal metabolic process (GO:0042574)2.47882774
138regulation of cholesterol biosynthetic process (GO:0045540)2.45412391
139positive regulation of lipid storage (GO:0010884)2.44919046
140plasma lipoprotein particle assembly (GO:0034377)2.42683416
141regulation of cholesterol esterification (GO:0010872)2.40132019
142wound healing, spreading of epidermal cells (GO:0035313)2.39528049
143iron ion import (GO:0097286)2.39475949
144diterpenoid biosynthetic process (GO:0016102)2.38181334
145negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.36794970
146low-density lipoprotein particle remodeling (GO:0034374)2.36367915
147phospholipid homeostasis (GO:0055091)2.34555400
148diacylglycerol metabolic process (GO:0046339)2.33637760
149UDP-N-acetylglucosamine metabolic process (GO:0006047)2.32681271
150positive regulation of steroid biosynthetic process (GO:0010893)2.31579998
151cholesterol transport (GO:0030301)2.31038253
152sterol transport (GO:0015918)2.31038253
153negative regulation of anoikis (GO:2000811)2.31004434
154negative regulation of sterol transport (GO:0032372)2.30805881
155negative regulation of cholesterol transport (GO:0032375)2.30805881
156ethanol oxidation (GO:0006069)2.30721405
157positive regulation of alcohol biosynthetic process (GO:1902932)2.30206201
158regulation of endothelial cell apoptotic process (GO:2000351)2.29876675
159cell-substrate adherens junction assembly (GO:0007045)2.29430783
160focal adhesion assembly (GO:0048041)2.29430783
161cellular glucuronidation (GO:0052695)2.27898189
162fibrinolysis (GO:0042730)2.27832609
163mammary gland epithelial cell proliferation (GO:0033598)2.27368513
164mannose metabolic process (GO:0006013)2.25619388
165cGMP-mediated signaling (GO:0019934)2.24670711
166regulation of vitamin metabolic process (GO:0030656)2.24274260
167interleukin-6-mediated signaling pathway (GO:0070102)2.22205985
168dicarboxylic acid biosynthetic process (GO:0043650)2.21573191
169negative regulation of hemostasis (GO:1900047)2.21318065
170negative regulation of blood coagulation (GO:0030195)2.21318065
171negative regulation of lipid biosynthetic process (GO:0051055)2.20841639
172glomerular visceral epithelial cell development (GO:0072015)2.20810719
173cell-substrate junction assembly (GO:0007044)2.20320283
174positive regulation of fatty acid beta-oxidation (GO:0032000)2.20082265
175regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.19914886

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.36421048
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.26187603
3* LXR_22158963_ChIP-Seq_LIVER_Mouse3.88157470
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.47005737
5EGR1_23403033_ChIP-Seq_LIVER_Mouse2.94974061
6SMAD_19615063_ChIP-ChIP_OVARY_Human2.85485777
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.72866862
8TP63_17297297_ChIP-ChIP_HaCaT_Human2.27859240
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.19811921
10ESR1_20079471_ChIP-ChIP_T-47D_Human2.15761912
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.15047011
12MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.14718678
13NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.08300572
14AHR_22903824_ChIP-Seq_MCF-7_Human1.98319393
15Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.92800323
16PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.90158354
17GATA1_22025678_ChIP-Seq_K562_Human1.83331285
18TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.82568561
19CTNNB1_20460455_ChIP-Seq_HCT116_Human1.81139515
20TP53_16413492_ChIP-PET_HCT116_Human1.75201403
21RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.74284415
22CDX2_20551321_ChIP-Seq_CACO-2_Human1.72942210
23CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.61725699
24* FOXA2_19822575_ChIP-Seq_HepG2_Human1.60967464
25SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.59839834
26EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.59021468
27ARNT_22903824_ChIP-Seq_MCF-7_Human1.53160039
28TRIM28_21343339_ChIP-Seq_HEK293_Human1.52593573
29TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50916810
30PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.49920889
31EGR1_19374776_ChIP-ChIP_THP-1_Human1.49872856
32CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.49542485
33SOX2_20726797_ChIP-Seq_SW620_Human1.47867511
34BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.44390341
35FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.42612186
36SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.39577612
37SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.39577612
38SOX9_24532713_ChIP-Seq_HFSC_Mouse1.37066730
39TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33953494
40* IRF8_27001747_Chip-Seq_BMDM_Mouse1.31088705
41FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.30367814
42NR3C1_23031785_ChIP-Seq_PC12_Mouse1.29413489
43PIAS1_25552417_ChIP-Seq_VCAP_Human1.29330662
44CDX2_19796622_ChIP-Seq_MESCs_Mouse1.28592341
45GATA2_21666600_ChIP-Seq_HMVEC_Human1.27743973
46VDR_24787735_ChIP-Seq_THP-1_Human1.25777833
47CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.23490726
48HIF1A_21447827_ChIP-Seq_MCF-7_Human1.22678036
49PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.21492411
50ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.21143634
51* FOXO3_23340844_ChIP-Seq_DLD1_Human1.20761912
52PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.16404357
53IRF8_22096565_ChIP-ChIP_GC-B_Human1.15863143
54NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.14939178
55SOX2_27498859_Chip-Seq_STOMACH_Mouse1.13313780
56* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.12760406
57IRF8_21731497_ChIP-ChIP_J774_Mouse1.12008250
58IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.10794342
59TBX20_22080862_ChIP-Seq_HEART_Mouse1.10772883
60TBX20_22328084_ChIP-Seq_HEART_Mouse1.10772883
61TCF4_18268006_ChIP-ChIP_LS174T_Human1.10246427
62PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.10125551
63VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.09457699
64FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.09221049
65CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.08734578
66* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.08237606
67PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.07139014
68* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05955621
69PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03729167
70GATA4_25053715_ChIP-Seq_YYC3_Human1.03632018
71NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.02945706
72ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.02403359
73NRF2_20460467_ChIP-Seq_MEFs_Mouse1.02172653
74NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.02172653
75SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01644357
76TP53_18474530_ChIP-ChIP_U2OS_Human1.01404370
77SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.01287240
78BRD4_25478319_ChIP-Seq_HGPS_Human1.01258084
79* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.99648672
80STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.99425459
81SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98511742
82* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.98262188
83ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97750632
84SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.97423236
85EP300_21415370_ChIP-Seq_HL-1_Mouse0.96280767
86KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.96210749
87ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.95588464
88* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95502603
89STAT3_23295773_ChIP-Seq_U87_Human0.94702633
90* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94123495
91ESR2_21235772_ChIP-Seq_MCF-7_Human0.93979541
92AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92602750
93AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.91779301
94P300_27058665_Chip-Seq_ZR-75-30cells_Human0.91626812
95* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.91225209
96GATA6_25053715_ChIP-Seq_YYC3_Human0.90695150
97STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.90555587
98KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.90089634
99NR3C1_21868756_ChIP-Seq_MCF10A_Human0.89777892
100CJUN_26792858_Chip-Seq_BT549_Human0.89458230
101* NFIB_24661679_ChIP-Seq_LUNG_Mouse0.89442625
102* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.89218013
103BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.88199568
104PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87588992
105GATA1_19941826_ChIP-Seq_K562_Human0.87439824
106CBP_21632823_ChIP-Seq_H3396_Human0.87411806
107FOXA1_25552417_ChIP-Seq_VCAP_Human0.85026420
108CDX2_22108803_ChIP-Seq_LS180_Human0.84916242
109* HNF4A_19822575_ChIP-Seq_HepG2_Human0.84682722
110TP63_23658742_ChIP-Seq_EP156T_Human0.84532742
111ELK4_26923725_Chip-Seq_MESODERM_Mouse0.81226097
112CLOCK_20551151_ChIP-Seq_293T_Human0.81204552
113GF1_26923725_Chip-Seq_HPCs_Mouse0.80302897
114* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.80289383
115STAT1_17558387_ChIP-Seq_HELA_Human0.80022890
116* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.79637556
117GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.79627793
118ESET_19884257_ChIP-Seq_ESCs_Mouse0.79548148
119* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.79239004
120SMAD4_21741376_ChIP-Seq_EPCs_Human0.78981990
121OCT4_20526341_ChIP-Seq_ESCs_Human0.78523021
122HTT_18923047_ChIP-ChIP_STHdh_Human0.77697978
123CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.77625739
124RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.76784514
125TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.75584179
126* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.74339737
127BRD4_27068464_Chip-Seq_AML-cells_Mouse0.74227183
128VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.74083408
129P53_21459846_ChIP-Seq_SAOS-2_Human0.73411230
130GATA3_26560356_Chip-Seq_TH1_Human0.73162082
131FLI1_21867929_ChIP-Seq_TH2_Mouse0.72849390
132KDM2B_26808549_Chip-Seq_REH_Human0.72772175
133TBL1_22424771_ChIP-Seq_293T_Human0.72733148
134TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.72729359
135* GATA2_19941826_ChIP-Seq_K562_Human0.72619005
136MYB_21317192_ChIP-Seq_ERMYB_Mouse0.71551929
137KLF4_19829295_ChIP-Seq_ESCs_Human0.71534691
138GATA1_19941827_ChIP-Seq_MEL86_Mouse0.71176575
139FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.70617942
140RARG_19884340_ChIP-ChIP_MEFs_Mouse0.70213204
141CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.69982184
142CRX_20693478_ChIP-Seq_RETINA_Mouse0.69700253
143NFYB_21822215_ChIP-Seq_K562_Human0.69581658
144EZH2_27294783_Chip-Seq_NPCs_Mouse0.68560557
145* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.68331777
146AUTS2_25519132_ChIP-Seq_293T-REX_Human0.68324428
147ESR1_21235772_ChIP-Seq_MCF-7_Human0.68158180
148CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.68018162

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization5.29109551
2MP0002139_abnormal_hepatobiliary_system5.21208333
3MP0005360_urolithiasis4.83434651
4MP0005365_abnormal_bile_salt3.93153100
5MP0003195_calcinosis3.62060354
6MP0005085_abnormal_gallbladder_physiolo3.60248291
7MP0008875_abnormal_xenobiotic_pharmacok3.14843575
8MP0003806_abnormal_nucleotide_metabolis2.93698081
9MP0003252_abnormal_bile_duct2.84702869
10MP0009840_abnormal_foam_cell2.78234283
11MP0000920_abnormal_myelination2.35818484
12MP0003950_abnormal_plasma_membrane2.22282210
13MP0005058_abnormal_lysosome_morphology2.17760515
14MP0004043_abnormal_pH_regulation2.16694487
15MP0004272_abnormal_basement_membrane2.14982129
16MP0010329_abnormal_lipoprotein_level2.11649462
17MP0005083_abnormal_biliary_tract2.09655264
18MP0010234_abnormal_vibrissa_follicle2.04873653
19MP0005332_abnormal_amino_acid2.03045388
20MP0005409_darkened_coat_color2.00650706
21MP0010352_gastrointestinal_tract_polyps1.92592705
22MP0000569_abnormal_digit_pigmentation1.92086892
23MP0003091_abnormal_cell_migration1.87587690
24MP0003690_abnormal_glial_cell1.86879590
25MP0003566_abnormal_cell_adhesion1.86861001
26MP0002118_abnormal_lipid_homeostasis1.85566293
27MP0005670_abnormal_white_adipose1.73251301
28MP0008438_abnormal_cutaneous_collagen1.65145684
29MP0003453_abnormal_keratinocyte_physiol1.62619192
30MP0003300_gastrointestinal_ulcer1.55634539
31MP0003191_abnormal_cellular_cholesterol1.54994944
32MP0005451_abnormal_body_composition1.54890728
33MP0003698_abnormal_male_reproductive1.50715272
34MP0000604_amyloidosis1.50141397
35MP0000609_abnormal_liver_physiology1.50084020
36MP0005023_abnormal_wound_healing1.47716141
37MP0005164_abnormal_response_to1.46724062
38MP0001666_abnormal_nutrient_absorption1.44260248
39MP0001958_emphysema1.43739562
40MP0001929_abnormal_gametogenesis1.42972762
41MP0002138_abnormal_hepatobiliary_system1.39008639
42MP0005076_abnormal_cell_differentiation1.35677602
43MP0001661_extended_life_span1.31695167
44MP0004019_abnormal_vitamin_homeostasis1.31200819
45MP0005666_abnormal_adipose_tissue1.30082407
46MP0005595_abnormal_vascular_smooth1.28854172
47MP0003868_abnormal_feces_composition1.28644169
48MP0005319_abnormal_enzyme/_coenzyme1.27614974
49MP0009643_abnormal_urine_homeostasis1.26839742
50MP0001915_intracranial_hemorrhage1.26722092
51MP0002933_joint_inflammation1.25996503
52MP0004134_abnormal_chest_morphology1.25459140
53MP0010678_abnormal_skin_adnexa1.24530497
54MP0006082_CNS_inflammation1.23814146
55MP0009780_abnormal_chondrocyte_physiolo1.18771734
56MP0003329_amyloid_beta_deposits1.18418955
57MP0009115_abnormal_fat_cell1.18297189
58MP0003656_abnormal_erythrocyte_physiolo1.17945511
59MP0005167_abnormal_blood-brain_barrier1.15627383
60* MP0005584_abnormal_enzyme/coenzyme_acti1.15266331
61MP0001851_eye_inflammation1.14924387
62MP0002876_abnormal_thyroid_physiology1.13208104
63MP0005375_adipose_tissue_phenotype1.11687958
64MP0003436_decreased_susceptibility_to1.08771560
65MP0010368_abnormal_lymphatic_system1.07828066
66MP0000013_abnormal_adipose_tissue1.07716420
67MP0001533_abnormal_skeleton_physiology1.07585934
68MP0005408_hypopigmentation1.06915709
69MP0003303_peritoneal_inflammation1.06730237
70MP0004185_abnormal_adipocyte_glucose1.06319132
71MP0000003_abnormal_adipose_tissue1.02288458
72MP0004130_abnormal_muscle_cell1.01855528
73MP0003705_abnormal_hypodermis_morpholog1.00511114
74MP0008004_abnormal_stomach_pH1.00391454
75MP0004233_abnormal_muscle_weight0.99243790
76MP0006054_spinal_hemorrhage0.98900595
77MP0002877_abnormal_melanocyte_morpholog0.98690106
78MP0000249_abnormal_blood_vessel0.98416864
79MP0000383_abnormal_hair_follicle0.98328948
80MP0002295_abnormal_pulmonary_circulatio0.98028875
81MP0005165_increased_susceptibility_to0.97469314
82MP0005257_abnormal_intraocular_pressure0.95895716
83MP0005647_abnormal_sex_gland0.95757183
84MP0001765_abnormal_ion_homeostasis0.94751260
85MP0000767_abnormal_smooth_muscle0.93736899
86MP0000343_altered_response_to0.93713228
87MP0006138_congestive_heart_failure0.93267597
88MP0000371_diluted_coat_color0.93036466
89MP0003279_aneurysm0.91407917
90MP0003646_muscle_fatigue0.90524944
91MP0003172_abnormal_lysosome_physiology0.88746620
92MP0003183_abnormal_peptide_metabolism0.87458864
93MP0003828_pulmonary_edema0.86290298
94MP0003011_delayed_dark_adaptation0.85078194
95MP0003075_altered_response_to0.83971065
96MP0002971_abnormal_brown_adipose0.83689710
97MP0003634_abnormal_glial_cell0.82970352
98MP0002161_abnormal_fertility/fecundity0.82739731
99MP0003879_abnormal_hair_cell0.82622746
100MP0004215_abnormal_myocardial_fiber0.81646888
101MP0003186_abnormal_redox_activity0.81315746
102MP0009763_increased_sensitivity_to0.81287606
103MP0008469_abnormal_protein_level0.80507076
104MP0009764_decreased_sensitivity_to0.79677093
105MP0005275_abnormal_skin_tensile0.79450151
106MP0002078_abnormal_glucose_homeostasis0.77931473
107MP0002909_abnormal_adrenal_gland0.77926732
108MP0001764_abnormal_homeostasis0.77916815
109MP0003632_abnormal_nervous_system0.77763167
110MP0004036_abnormal_muscle_relaxation0.76240941
111MP0000598_abnormal_liver_morphology0.75447351
112MP0003724_increased_susceptibility_to0.75009012
113MP0003045_fibrosis0.74482390
114MP0002970_abnormal_white_adipose0.74187099
115MP0004510_myositis0.73162306
116MP0005636_abnormal_mineral_homeostasis0.72797194
117MP0005166_decreased_susceptibility_to0.71839275
118MP0001756_abnormal_urination0.71489715
119MP0002168_other_aberrant_phenotype0.71398207
120MP0002896_abnormal_bone_mineralization0.70374524
121MP0005334_abnormal_fat_pad0.69983834
122MP0005535_abnormal_body_temperature0.69950773
123MP0002210_abnormal_sex_determination0.69572317
124MP0002419_abnormal_innate_immunity0.69054523
125MP0003959_abnormal_lean_body0.68027685
126MP0002837_dystrophic_cardiac_calcinosis0.66315269
127MP0002998_abnormal_bone_remodeling0.65432089
128MP0002090_abnormal_vision0.65341046
129MP0003633_abnormal_nervous_system0.64667156
130MP0002332_abnormal_exercise_endurance0.64204894
131MP0009642_abnormal_blood_homeostasis0.61688819
132MP0001145_abnormal_male_reproductive0.60251872
133MP0005448_abnormal_energy_balance0.60242713
134MP0000639_abnormal_adrenal_gland0.59801558
135MP0004885_abnormal_endolymph0.59568171
136MP0002136_abnormal_kidney_physiology0.59395371
137MP0002229_neurodegeneration0.59230350
138MP0004947_skin_inflammation0.58546756
139MP0000230_abnormal_systemic_arterial0.58265717
140MP0001879_abnormal_lymphatic_vessel0.56876543
141MP0002282_abnormal_trachea_morphology0.55830775
142MP0000747_muscle_weakness0.54373280

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.92140034
2Abnormality of aromatic amino acid family metabolism (HP:0004338)4.67705615
3Intrahepatic cholestasis (HP:0001406)4.24049056
4Dynein arm defect of respiratory motile cilia (HP:0012255)4.12766529
5Absent/shortened dynein arms (HP:0200106)4.12766529
6Xanthomatosis (HP:0000991)3.95739075
7Deep venous thrombosis (HP:0002625)3.72951906
8Epiphyseal dysplasia (HP:0002656)3.48335177
9Neurofibrillary tangles (HP:0002185)3.37828648
10Protuberant abdomen (HP:0001538)3.34051252
11Abnormal tarsal ossification (HP:0008369)3.30012514
12Mitral stenosis (HP:0001718)3.19978840
13Hypoplastic ischia (HP:0003175)3.18868710
14Hyperlipoproteinemia (HP:0010980)3.14616630
15Axonal loss (HP:0003447)3.12626201
16Rhinitis (HP:0012384)3.12128263
17Hemorrhage of the eye (HP:0011885)3.11756876
18Abnormal respiratory motile cilium physiology (HP:0012261)3.10530001
19Metaphyseal cupping (HP:0003021)3.02614441
20Glomerulonephritis (HP:0000099)2.98134241
21Abnormality of the ischium (HP:0003174)2.93798484
22Prolonged partial thromboplastin time (HP:0003645)2.89864003
23Vitreoretinal degeneration (HP:0000655)2.84837205
24Complement deficiency (HP:0004431)2.83696730
25Abnormality of monocarboxylic acid metabolism (HP:0010996)2.81457367
26Cupped ribs (HP:0000887)2.76489658
27Hypoglycemic coma (HP:0001325)2.74798933
28Chronic bronchitis (HP:0004469)2.71717246
29Ketosis (HP:0001946)2.71663594
30Vascular calcification (HP:0004934)2.71378984
31Joint hemorrhage (HP:0005261)2.71266860
32Arterial tortuosity (HP:0005116)2.64060296
33Protrusio acetabuli (HP:0003179)2.63156424
34Epidermoid cyst (HP:0200040)2.60404826
35Abnormality of glutamine family amino acid metabolism (HP:0010902)2.60322574
36Abnormal foot bone ossification (HP:0010675)2.59403692
37Focal segmental glomerulosclerosis (HP:0000097)2.58717339
38Conjugated hyperbilirubinemia (HP:0002908)2.57047528
39Cardiovascular calcification (HP:0011915)2.56048848
40Abnormality of liposaccharide metabolism (HP:0010968)2.55972009
41Abnormality of glycosphingolipid metabolism (HP:0004343)2.55972009
42Abnormality of glycolipid metabolism (HP:0010969)2.55972009
43Flat acetabular roof (HP:0003180)2.52741855
44Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.52357340
45Infertility (HP:0000789)2.48386691
46Small epiphyses (HP:0010585)2.46462365
47Abnormality of aspartate family amino acid metabolism (HP:0010899)2.44548338
48Vascular tortuosity (HP:0004948)2.44179117
49Nephritis (HP:0000123)2.43910130
50Myocardial infarction (HP:0001658)2.43761271
51Hypoalphalipoproteinemia (HP:0003233)2.43082448
52Cerebral inclusion bodies (HP:0100314)2.41953811
53Abnormality of sulfur amino acid metabolism (HP:0004339)2.39721228
54Osteolytic defects of the phalanges of the hand (HP:0009771)2.38059308
55Osteolytic defects of the hand bones (HP:0009699)2.38059308
56Hypercholesterolemia (HP:0003124)2.37234184
57Mucopolysacchariduria (HP:0008155)2.33272565
58Urinary glycosaminoglycan excretion (HP:0003541)2.33272565
59Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.32516635
60Degeneration of the lateral corticospinal tracts (HP:0002314)2.32516635
61Abnormal respiratory motile cilium morphology (HP:0005938)2.31388439
62Abnormal respiratory epithelium morphology (HP:0012253)2.31388439
63Abnormality of methionine metabolism (HP:0010901)2.30955606
64Hyperinsulinemic hypoglycemia (HP:0000825)2.29947393
65Cerebral aneurysm (HP:0004944)2.29809192
66Scanning speech (HP:0002168)2.29747678
67Irregular epiphyses (HP:0010582)2.29097908
68Abnormality of the periventricular white matter (HP:0002518)2.27465152
69Fat malabsorption (HP:0002630)2.27341559
70Nasal polyposis (HP:0100582)2.27255790
71Short chin (HP:0000331)2.26272172
72Onion bulb formation (HP:0003383)2.26253994
73Peripheral demyelination (HP:0011096)2.25029628
74Spastic tetraparesis (HP:0001285)2.23703611
75Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.22270944
76Abnormality of the common coagulation pathway (HP:0010990)2.22073752
77Abnormality of the intrinsic pathway (HP:0010989)2.21235155
78Spondylolisthesis (HP:0003302)2.19746005
79Abnormality of mucopolysaccharide metabolism (HP:0011020)2.18843835
80Abnormality of polysaccharide metabolism (HP:0011012)2.18843835
81Abnormality of glycosaminoglycan metabolism (HP:0004371)2.18843835
82Malnutrition (HP:0004395)2.16608538
83Abnormal ciliary motility (HP:0012262)2.13862466
84Hyperammonemia (HP:0001987)2.12185840
85Premature rupture of membranes (HP:0001788)2.10730462
86Abnormality of purine metabolism (HP:0004352)2.10688881
87Abnormality of fatty-acid metabolism (HP:0004359)2.10147613
88Abnormality of the nasal mucosa (HP:0000433)2.10137622
89Hypoglycemic seizures (HP:0002173)2.08873468
90Hypolipoproteinemia (HP:0010981)2.08349350
91Tetraparesis (HP:0002273)2.08276373
92Wormian bones (HP:0002645)2.08106653
93Recurrent gram-negative bacterial infections (HP:0005420)2.07272315
94Abnormality of complement system (HP:0005339)2.07030117
95Muscle fiber splitting (HP:0003555)2.06925359
96Abnormal gallbladder physiology (HP:0012438)2.06541875
97Cholecystitis (HP:0001082)2.06541875
98Lower limb hyperreflexia (HP:0002395)2.06466297
99Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.04945411
100Ovoid vertebral bodies (HP:0003300)2.04634054
101Esophageal varix (HP:0002040)2.03315055
102Hypokalemic alkalosis (HP:0001949)2.02979061
103Hypobetalipoproteinemia (HP:0003563)2.02109241
104Delayed epiphyseal ossification (HP:0002663)2.02038672
105Abnormality of the vertebral endplates (HP:0005106)2.00828313
106Abnormality of glycine metabolism (HP:0010895)2.00694969
107Abnormality of serine family amino acid metabolism (HP:0010894)2.00694969
108Flattened epiphyses (HP:0003071)2.00345433
109Ketoacidosis (HP:0001993)1.99666606
110Hyporeflexia of lower limbs (HP:0002600)1.97181679
111Hyperventilation (HP:0002883)1.96623083
112Glomerulosclerosis (HP:0000096)1.96622166
113Polycythemia (HP:0001901)1.95384951
114Abnormality of proline metabolism (HP:0010907)1.95317745
115Hydroxyprolinuria (HP:0003080)1.95317745
116Thin bony cortex (HP:0002753)1.94159763
117Metabolic alkalosis (HP:0200114)1.92849808
118Aneurysm (HP:0002617)1.90327887
119Cervical subluxation (HP:0003308)1.89927386
120Coarse hair (HP:0002208)1.89314207
121Retinal atrophy (HP:0001105)1.89207799
122Skin nodule (HP:0200036)1.88274058
123Abnormal enzyme/coenzyme activity (HP:0012379)1.88150858
124Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.87460386
125Broad metatarsal (HP:0001783)1.86808329
126Vertebral arch anomaly (HP:0008438)1.85093416
127Male infertility (HP:0003251)1.84534848
128Irregular vertebral endplates (HP:0003301)1.84382808
129Systemic lupus erythematosus (HP:0002725)1.83483870
130Fair hair (HP:0002286)1.82884185
131Absent epiphyses (HP:0010577)1.81598184
132Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.81598184
133Aortic dissection (HP:0002647)1.81212002
134Elevated alkaline phosphatase (HP:0003155)1.80169579
135Generalized hypopigmentation of hair (HP:0011358)1.79354376
136Action tremor (HP:0002345)1.79040347
137Arthropathy (HP:0003040)1.78326535
138Steatorrhea (HP:0002570)1.77805248
139Generalized aminoaciduria (HP:0002909)1.77615174
140Abnormality of alkaline phosphatase activity (HP:0004379)1.76916607
141Conjunctival telangiectasia (HP:0000524)1.76798773
142Dysostosis multiplex (HP:0000943)1.76439590
143Abnormality of femoral epiphyses (HP:0006499)1.76089211
144Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.76089211
145Bronchomalacia (HP:0002780)1.75564523
146Aortic aneurysm (HP:0004942)1.75287946
147Neonatal short-limb short stature (HP:0008921)1.75012918
148Asymmetric septal hypertrophy (HP:0001670)1.74380838
149Blue irides (HP:0000635)1.74281685
150Papillary thyroid carcinoma (HP:0002895)1.74228210
151Submucous cleft hard palate (HP:0000176)1.73855997
152Subcapsular cataract (HP:0000523)1.71658445
153Macroorchidism (HP:0000053)1.71513549
154Polar cataract (HP:0010696)1.71340700
155Exocrine pancreatic insufficiency (HP:0001738)1.71289070
156Bundle branch block (HP:0011710)1.69959488
157Neonatal death (HP:0003811)1.66627115
158Dysmetric saccades (HP:0000641)1.64232249
159Limited elbow extension (HP:0001377)1.62925905
160Hyperparathyroidism (HP:0000843)1.60677923
161Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.59627459
162Visceral angiomatosis (HP:0100761)1.59598275
163Vertebral compression fractures (HP:0002953)1.59391304
164Spinal cord compression (HP:0002176)1.56392543
165Metaphyseal dysplasia (HP:0100255)1.56148927

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.37613072
2PDK34.05940410
3PDK44.05940410
4WNK43.50762160
5PDK23.49459666
6MST1R3.13004865
7PRKD32.89197128
8EPHB12.87989496
9PDGFRA2.43973699
10TESK12.25334322
11ERN12.23155262
12OXSR12.20677449
13ICK2.18269759
14WNK12.09707323
15NEK91.99648458
16TAOK31.87540836
17INSRR1.83637540
18MET1.83536838
19PBK1.77891530
20FGFR31.75485863
21ACVR1B1.70752354
22NTRK31.66430627
23KSR21.59710223
24FGFR21.57624598
25PTK2B1.54479908
26BMPR21.53999461
27CAMK1G1.53677388
28AKT31.51977268
29BCKDK1.49669526
30LMTK21.46581903
31MAPK151.44544172
32EPHA21.37295268
33PKN11.36770420
34MAP3K131.31824818
35PTK61.21570228
36ZAP701.21082422
37CDC42BPA1.19809476
38STK31.11827272
39TESK21.08265879
40TRIB31.07956010
41CAMK1D1.07306250
42PNCK1.06663578
43CDK121.06255465
44TRPM71.03095408
45SIK11.01236770
46PIK3CA1.00015250
47PDPK10.99873042
48FGFR40.99425430
49PDK10.99071880
50MELK0.97813565
51BLK0.97580985
52TIE10.96823192
53GSK3A0.95084183
54EEF2K0.93511850
55DYRK1B0.93101612
56PRKCH0.92460241
57SGK2230.86709865
58SGK4940.86709865
59MAP3K30.83145877
60MAPKAPK50.82706630
61EPHA30.82699150
62LATS10.81838616
63WNK30.81706827
64PRPF4B0.81517797
65CSNK1A1L0.81095972
66ERBB40.81087306
67CSK0.79906704
68MAPK110.78453657
69PRKD10.76990011
70LATS20.76908330
71PINK10.76464949
72FRK0.74757872
73MAP2K10.73263384
74KSR10.70885921
75TBK10.70210113
76DMPK0.69035605
77RIPK10.68950907
78MOS0.67726145
79BCR0.66722946
80JAK10.64389791
81MYLK0.64315273
82PRKG20.63418151
83CAMK2D0.61850255
84MAP3K140.61356765
85PRKCQ0.60941055
86CSNK1G10.60673520
87NTRK20.59588745
88NTRK10.58849694
89PRKAA20.58652867
90MTOR0.56956678
91DDR20.56776990
92IRAK10.56063374
93YES10.55873793
94TTN0.55476972
95MAP3K90.54931308
96TGFBR20.52871092
97KDR0.52704428
98IRAK20.52124571
99PRKAA10.51915222
100TYRO30.51197724
101MAP3K120.51146986
102MAPK70.50263888
103MUSK0.50255484
104PKN20.49467401
105CSF1R0.48334866
106PDGFRB0.47919046
107MAP2K30.47530125
108ROCK10.47293867
109CHUK0.46665626
110PIK3CG0.46399833
111CSNK1G30.45211082
112MAP3K10.44383411
113ABL20.44215332
114NEK60.44168707
115IRAK30.43903124
116CAMKK20.43725422
117RET0.42933284
118STK240.42503576
119PRKD20.41925227
120MAPK120.41889035
121JAK20.41866444
122CLK10.41710721
123ITK0.41283786
124TYK20.41088411
125BMX0.40849494
126CAMK2B0.40733806
127CAMK2G0.39777732
128PAK60.39661096
129EGFR0.38864535
130MAPK100.38545175
131SGK20.38114149
132CSNK1G20.37397375
133MAP3K20.37336923
134PRKACG0.37020837
135STK38L0.35355875
136ABL10.34829436
137STK380.34563468
138PTK20.34043010
139GRK10.32920436
140SGK30.32483372
141FGR0.30639270

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.80558320
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.09129358
3Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.56615297
4Propanoate metabolism_Homo sapiens_hsa006402.40398536
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.37024430
6Fatty acid degradation_Homo sapiens_hsa000712.21160555
7Steroid biosynthesis_Homo sapiens_hsa001002.17536973
8Complement and coagulation cascades_Homo sapiens_hsa046102.06547643
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.05504213
10Sulfur metabolism_Homo sapiens_hsa009202.04907395
11Histidine metabolism_Homo sapiens_hsa003402.04790304
12PPAR signaling pathway_Homo sapiens_hsa033202.02319144
13Fatty acid elongation_Homo sapiens_hsa000622.02247037
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.98108527
15Fatty acid metabolism_Homo sapiens_hsa012121.97650187
16Arginine biosynthesis_Homo sapiens_hsa002201.97149748
17Tryptophan metabolism_Homo sapiens_hsa003801.91534998
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.79932283
19Pentose and glucuronate interconversions_Homo sapiens_hsa000401.78543652
20Vitamin B6 metabolism_Homo sapiens_hsa007501.75673302
21Butanoate metabolism_Homo sapiens_hsa006501.74936750
22Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.73072729
23Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.64797517
24Pyruvate metabolism_Homo sapiens_hsa006201.64717467
25Peroxisome_Homo sapiens_hsa041461.62841459
26Selenocompound metabolism_Homo sapiens_hsa004501.61270630
27Staphylococcus aureus infection_Homo sapiens_hsa051501.61022888
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.47458534
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.42614294
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.37854882
31Bile secretion_Homo sapiens_hsa049761.36307216
32AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.33637159
33Caffeine metabolism_Homo sapiens_hsa002321.32385873
34Chemical carcinogenesis_Homo sapiens_hsa052041.30266857
35beta-Alanine metabolism_Homo sapiens_hsa004101.29526891
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.28630772
37Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.28552308
38Folate biosynthesis_Homo sapiens_hsa007901.27927818
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.26587914
40ABC transporters_Homo sapiens_hsa020101.24884022
41alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.22872773
42Linoleic acid metabolism_Homo sapiens_hsa005911.13111486
43Focal adhesion_Homo sapiens_hsa045101.08857745
44Fat digestion and absorption_Homo sapiens_hsa049751.08795030
45Glycerolipid metabolism_Homo sapiens_hsa005611.08343530
46Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.06777125
47Arginine and proline metabolism_Homo sapiens_hsa003301.06505019
48TNF signaling pathway_Homo sapiens_hsa046681.05548168
49Fatty acid biosynthesis_Homo sapiens_hsa000611.04984842
50Retinol metabolism_Homo sapiens_hsa008301.04760142
51Starch and sucrose metabolism_Homo sapiens_hsa005001.04223988
52Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.00795969
53Cyanoamino acid metabolism_Homo sapiens_hsa004600.96941112
54Dorso-ventral axis formation_Homo sapiens_hsa043200.94039518
55Amoebiasis_Homo sapiens_hsa051460.93170129
56Vitamin digestion and absorption_Homo sapiens_hsa049770.92932613
57Lysosome_Homo sapiens_hsa041420.90543258
58Small cell lung cancer_Homo sapiens_hsa052220.90010076
59Lysine degradation_Homo sapiens_hsa003100.86790262
60Chronic myeloid leukemia_Homo sapiens_hsa052200.85370565
61Circadian rhythm_Homo sapiens_hsa047100.82179862
62Carbon metabolism_Homo sapiens_hsa012000.78920393
63Phenylalanine metabolism_Homo sapiens_hsa003600.76680805
64Phospholipase D signaling pathway_Homo sapiens_hsa040720.76482468
65Glycosaminoglycan degradation_Homo sapiens_hsa005310.76453522
66Thyroid hormone synthesis_Homo sapiens_hsa049180.76430489
67Pertussis_Homo sapiens_hsa051330.76315947
68Ether lipid metabolism_Homo sapiens_hsa005650.76138750
69Renin-angiotensin system_Homo sapiens_hsa046140.75249568
70Estrogen signaling pathway_Homo sapiens_hsa049150.75059017
71Tyrosine metabolism_Homo sapiens_hsa003500.74556724
72Adherens junction_Homo sapiens_hsa045200.74454347
73Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.74167711
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.73238967
75Sphingolipid metabolism_Homo sapiens_hsa006000.70961176
76Renal cell carcinoma_Homo sapiens_hsa052110.69639953
77Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.68834159
78Prolactin signaling pathway_Homo sapiens_hsa049170.68728728
79GnRH signaling pathway_Homo sapiens_hsa049120.68182526
80Protein digestion and absorption_Homo sapiens_hsa049740.67043777
81Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65346410
82Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.65159227
83Drug metabolism - other enzymes_Homo sapiens_hsa009830.64258853
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.64163288
85Proteoglycans in cancer_Homo sapiens_hsa052050.64137271
86ErbB signaling pathway_Homo sapiens_hsa040120.64042706
87Glutathione metabolism_Homo sapiens_hsa004800.63723673
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.63439546
89Inositol phosphate metabolism_Homo sapiens_hsa005620.61949333
90Choline metabolism in cancer_Homo sapiens_hsa052310.60046878
91Pancreatic cancer_Homo sapiens_hsa052120.59267268
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.59169341
93Pancreatic secretion_Homo sapiens_hsa049720.58459614
94Glioma_Homo sapiens_hsa052140.58150636
95Aldosterone synthesis and secretion_Homo sapiens_hsa049250.58118964
96African trypanosomiasis_Homo sapiens_hsa051430.57275659
97Biosynthesis of amino acids_Homo sapiens_hsa012300.56794516
98Toxoplasmosis_Homo sapiens_hsa051450.56685683
99Renin secretion_Homo sapiens_hsa049240.56458575
100VEGF signaling pathway_Homo sapiens_hsa043700.56448176
101Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.56165646
102Bladder cancer_Homo sapiens_hsa052190.55771612
103Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.55176555
104Insulin resistance_Homo sapiens_hsa049310.54313823
105Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54211017
106Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54106095
107Glucagon signaling pathway_Homo sapiens_hsa049220.53946285
108Galactose metabolism_Homo sapiens_hsa000520.53660358
109Malaria_Homo sapiens_hsa051440.53572395
110Insulin signaling pathway_Homo sapiens_hsa049100.52495135
111Pentose phosphate pathway_Homo sapiens_hsa000300.52325551
112Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51780053
113Hepatitis C_Homo sapiens_hsa051600.49620322
114Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49173971
115Ovarian steroidogenesis_Homo sapiens_hsa049130.47196062
116NF-kappa B signaling pathway_Homo sapiens_hsa040640.46965333
117Toll-like receptor signaling pathway_Homo sapiens_hsa046200.46534045
118mTOR signaling pathway_Homo sapiens_hsa041500.45127794
119HIF-1 signaling pathway_Homo sapiens_hsa040660.43159554
120ECM-receptor interaction_Homo sapiens_hsa045120.42041249
121Mineral absorption_Homo sapiens_hsa049780.41837571
122Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38866741
123Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37952844
124Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.36883339
125Other glycan degradation_Homo sapiens_hsa005110.36594989
126Phagosome_Homo sapiens_hsa041450.33509545
127Prion diseases_Homo sapiens_hsa050200.33365116
128Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.30253777
129Metabolic pathways_Homo sapiens_hsa011000.29232885
130Protein export_Homo sapiens_hsa030600.28280573
131Type II diabetes mellitus_Homo sapiens_hsa049300.27701794
132Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27448358
133AMPK signaling pathway_Homo sapiens_hsa041520.26862208
134Arachidonic acid metabolism_Homo sapiens_hsa005900.26623816
135Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.22534706
136Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.21793537
1372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.18046201
138Endocytosis_Homo sapiens_hsa041440.14285125
139Osteoclast differentiation_Homo sapiens_hsa043800.12936185
140Fructose and mannose metabolism_Homo sapiens_hsa000510.12056793
141Rheumatoid arthritis_Homo sapiens_hsa053230.10863813
142Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.09604241

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