PDCL3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the phosducin-like protein family and is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin. Members of the phosducin-like protein family have been shown to bind to the beta-gamma subunits of G proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.82803998
2negative regulation of retinoic acid receptor signaling pathway (GO:0048387)5.57843727
3ATP synthesis coupled proton transport (GO:0015986)5.56117713
4energy coupled proton transport, down electrochemical gradient (GO:0015985)5.56117713
5ribosomal small subunit biogenesis (GO:0042274)5.44229994
6ribosomal small subunit assembly (GO:0000028)5.04263027
7regulation of retinoic acid receptor signaling pathway (GO:0048385)5.02792607
8viral transcription (GO:0019083)4.90453078
9mitotic metaphase plate congression (GO:0007080)4.88180630
10proteasome assembly (GO:0043248)4.87095328
11translational termination (GO:0006415)4.76326894
12maturation of SSU-rRNA (GO:0030490)4.69244530
13CENP-A containing nucleosome assembly (GO:0034080)4.58421356
14rRNA modification (GO:0000154)4.56982206
15cullin deneddylation (GO:0010388)4.47917939
16SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.46945623
17cotranslational protein targeting to membrane (GO:0006613)4.44074587
18protein targeting to ER (GO:0045047)4.39535609
19chromatin remodeling at centromere (GO:0031055)4.38542654
20protein neddylation (GO:0045116)4.33755200
21negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.21826218
22metaphase plate congression (GO:0051310)4.19909834
23establishment of protein localization to endoplasmic reticulum (GO:0072599)4.18009920
24protein localization to endoplasmic reticulum (GO:0070972)4.13941204
25protein deneddylation (GO:0000338)4.13369592
26translational elongation (GO:0006414)4.06416114
27DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.02421433
28antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.98972026
29viral life cycle (GO:0019058)3.98833715
30transcription from mitochondrial promoter (GO:0006390)3.98764782
31establishment of integrated proviral latency (GO:0075713)3.95349733
32regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.93704515
33cellular protein complex disassembly (GO:0043624)3.92156176
34mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.92000617
35intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.91980091
36signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.91980091
37negative regulation of ligase activity (GO:0051352)3.91941462
38negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.91941462
39positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.91499279
40translational initiation (GO:0006413)3.91283052
41rRNA methylation (GO:0031167)3.90989741
42regulation of DNA methylation (GO:0044030)3.85163038
43signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.84776701
44signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.84776701
45signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.84776701
46regulation of cellular amino acid metabolic process (GO:0006521)3.84465240
47establishment of protein localization to mitochondrial membrane (GO:0090151)3.83919085
48exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.82409346
49ribosomal large subunit biogenesis (GO:0042273)3.79307017
50antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.78167204
51histone exchange (GO:0043486)3.77733598
52signal transduction involved in DNA integrity checkpoint (GO:0072401)3.77251915
53signal transduction involved in DNA damage checkpoint (GO:0072422)3.77251915
54respiratory electron transport chain (GO:0022904)3.72922396
55nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.72518591
56signal transduction involved in cell cycle checkpoint (GO:0072395)3.71997827
57regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.71935665
58translation (GO:0006412)3.70807941
59anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.66819884
60formation of translation preinitiation complex (GO:0001731)3.64008164
61electron transport chain (GO:0022900)3.63693700
62mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.62745195
63mitochondrial respiratory chain complex I assembly (GO:0032981)3.62745195
64NADH dehydrogenase complex assembly (GO:0010257)3.62745195
65establishment of chromosome localization (GO:0051303)3.62712603
66L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.60034592
67positive regulation of chromosome segregation (GO:0051984)3.49330389
68regulation of meiosis I (GO:0060631)3.49155610
69nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.48708544
70sequestering of actin monomers (GO:0042989)3.46856610
71pseudouridine synthesis (GO:0001522)3.45748960
72nucleobase-containing small molecule interconversion (GO:0015949)3.45449430
73DNA replication-independent nucleosome assembly (GO:0006336)3.42148668
74DNA replication-independent nucleosome organization (GO:0034724)3.42148668
75regulation of mitochondrial translation (GO:0070129)3.41517039
76histone mRNA metabolic process (GO:0008334)3.40816116
77protein localization to kinetochore (GO:0034501)3.37946539
78positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.35398147
79ribonucleoprotein complex biogenesis (GO:0022613)3.35332482
80maturation of 5.8S rRNA (GO:0000460)3.33526353
81mitochondrial RNA metabolic process (GO:0000959)3.31663308
82positive regulation of actin filament depolymerization (GO:0030836)3.31188398
83ribosome biogenesis (GO:0042254)3.26146214
84DNA replication checkpoint (GO:0000076)3.25275764
85positive regulation of cell cycle arrest (GO:0071158)3.23407244
86positive regulation of ligase activity (GO:0051351)3.22899328
87rRNA metabolic process (GO:0016072)3.22824320
88kinetochore organization (GO:0051383)3.20184004
89protein K6-linked ubiquitination (GO:0085020)3.19797623
90transcription elongation from RNA polymerase I promoter (GO:0006362)3.17710580
91protein complex disassembly (GO:0043241)3.17351115
92respiratory chain complex IV assembly (GO:0008535)3.16787076
93protein localization to chromosome, centromeric region (GO:0071459)3.16449289
94chaperone-mediated protein transport (GO:0072321)3.15946470
95antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)3.14030980
96kinetochore assembly (GO:0051382)3.13326767
97male meiosis I (GO:0007141)3.12709589
98regulation of oxidative phosphorylation (GO:0002082)3.12432211
99protein targeting to membrane (GO:0006612)3.12154536
100attachment of spindle microtubules to kinetochore (GO:0008608)3.10394048
101establishment of viral latency (GO:0019043)3.09315817
102telomere maintenance via semi-conservative replication (GO:0032201)3.08887968
103piRNA metabolic process (GO:0034587)3.08525803
104positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.07955163
105positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.07955163
106positive regulation of mitotic sister chromatid separation (GO:1901970)3.07955163
107meiosis I (GO:0007127)3.06170032
108protein complex biogenesis (GO:0070271)3.05547585
109DNA strand elongation involved in DNA replication (GO:0006271)3.04805356
110DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.04457558
1117-methylguanosine mRNA capping (GO:0006370)3.04309747
112cellular component biogenesis (GO:0044085)3.01831966
113RNA capping (GO:0036260)3.00392495
1147-methylguanosine RNA capping (GO:0009452)3.00392495
115macromolecular complex disassembly (GO:0032984)2.99761384
116de novo posttranslational protein folding (GO:0051084)2.99019709
117activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.97081922
118GTP biosynthetic process (GO:0006183)2.94833485
119de novo protein folding (GO:0006458)2.93943416
120establishment of protein localization to mitochondrion (GO:0072655)2.91531056
121regulation of ubiquitin-protein transferase activity (GO:0051438)2.91394486
122deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.87532487
123protein targeting to mitochondrion (GO:0006626)2.85637112
124regulation of ligase activity (GO:0051340)2.82857926
125negative regulation of G1/S transition of mitotic cell cycle (GO:2000134)2.82491110
126negative regulation of cell cycle G1/S phase transition (GO:1902807)2.82491110
127termination of RNA polymerase III transcription (GO:0006386)2.82377663
128transcription elongation from RNA polymerase III promoter (GO:0006385)2.82377663
129mitochondrial respiratory chain complex assembly (GO:0033108)2.81771354
130regulation of cell cycle arrest (GO:0071156)2.74951662
131negative regulation of striated muscle cell apoptotic process (GO:0010664)2.73429271
132peptidyl-histidine modification (GO:0018202)2.73312795
133G1/S transition of mitotic cell cycle (GO:0000082)2.72096749
134cell cycle G1/S phase transition (GO:0044843)2.72096749
135oxidative phosphorylation (GO:0006119)2.69421742
136regulation of cellular amine metabolic process (GO:0033238)2.67495190
137rRNA processing (GO:0006364)2.66714211
138termination of RNA polymerase I transcription (GO:0006363)2.65054811
139UTP biosynthetic process (GO:0006228)2.64902767
140transcription from RNA polymerase I promoter (GO:0006360)2.64611709
141ventricular cardiac muscle cell development (GO:0055015)2.63835253
142protein localization to mitochondrion (GO:0070585)2.57593469
143signal transduction in response to DNA damage (GO:0042770)2.55881465
144guanosine-containing compound biosynthetic process (GO:1901070)2.55469447
145spliceosomal snRNP assembly (GO:0000387)2.55443935
146ribosome assembly (GO:0042255)2.55206863

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.61951826
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.16148517
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.13992963
4MYC_18555785_ChIP-Seq_MESCs_Mouse4.13581711
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.83416254
6CREB1_15753290_ChIP-ChIP_HEK293T_Human3.42553602
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.41013317
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.32278918
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.26202461
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.24090671
11TRIM28_21343339_ChIP-Seq_HEK293_Human2.98786115
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.91563397
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.87658410
14ELK1_19687146_ChIP-ChIP_HELA_Human2.76804497
15TP63_17297297_ChIP-ChIP_HaCaT_Human2.70840799
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.64516603
17E2F7_22180533_ChIP-Seq_HELA_Human2.64091168
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.62361606
19FOXM1_23109430_ChIP-Seq_U2OS_Human2.61764842
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.61306265
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.58744043
22MYC_19030024_ChIP-ChIP_MESCs_Mouse2.58553182
23TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.53880899
24DCP1A_22483619_ChIP-Seq_HELA_Human2.47812542
25E2F1_18555785_ChIP-Seq_MESCs_Mouse2.35345685
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.34499317
27ELK1_22589737_ChIP-Seq_MCF10A_Human2.27381921
28XRN2_22483619_ChIP-Seq_HELA_Human2.19644067
29* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.16283362
30VDR_23849224_ChIP-Seq_CD4+_Human2.13310370
31NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.07546660
32NOTCH1_21737748_ChIP-Seq_TLL_Human2.06159525
33TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.03288164
34BP1_19119308_ChIP-ChIP_Hs578T_Human2.03151569
35TTF2_22483619_ChIP-Seq_HELA_Human2.01961877
36MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.97215541
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.97100625
38E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.96087478
39SRF_21415370_ChIP-Seq_HL-1_Mouse1.94656778
40RARG_19884340_ChIP-ChIP_MEFs_Mouse1.88835041
41FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.84602923
42YY1_21170310_ChIP-Seq_MESCs_Mouse1.75001844
43AR_21909140_ChIP-Seq_LNCAP_Human1.72449223
44ELF1_17652178_ChIP-ChIP_JURKAT_Human1.72124982
45PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.70533745
46HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.68911151
47CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.65117004
48SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.65078709
49* GABP_19822575_ChIP-Seq_HepG2_Human1.61172816
50THAP11_20581084_ChIP-Seq_MESCs_Mouse1.60967124
51FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.59456950
52FOXP3_21729870_ChIP-Seq_TREG_Human1.59022229
53ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.58827146
54CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.58112447
55NANOG_18555785_ChIP-Seq_MESCs_Mouse1.53415643
56POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.52139063
57CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.49075402
58E2F4_17652178_ChIP-ChIP_JURKAT_Human1.48407412
59MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.48265621
60FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.46322389
61HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.46292928
62KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.46176782
63POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.46071766
64* SOX17_20123909_ChIP-Seq_XEN_Mouse1.44853446
65POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.42780958
66HOXB4_20404135_ChIP-ChIP_EML_Mouse1.42766933
67SALL1_21062744_ChIP-ChIP_HESCs_Human1.42484911
68MYC_18940864_ChIP-ChIP_HL60_Human1.40336866
69ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.39510602
70KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.38704216
71ZNF274_21170338_ChIP-Seq_K562_Hela1.37343602
72E2F1_21310950_ChIP-Seq_MCF-7_Human1.33912827
73PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.26591307
74* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.26002468
75OCT4_18692474_ChIP-Seq_MEFs_Mouse1.24256200
76TCF3_18692474_ChIP-Seq_MEFs_Mouse1.22322415
77CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.21388399
78VDR_22108803_ChIP-Seq_LS180_Human1.20202644
79PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20163284
80YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19059632
81MYCN_18555785_ChIP-Seq_MESCs_Mouse1.17857550
82WT1_19549856_ChIP-ChIP_CCG9911_Human1.17330817
83* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.16546019
84STAT6_21828071_ChIP-Seq_BEAS2B_Human1.15470041
85* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.15213728
86EWS_26573619_Chip-Seq_HEK293_Human1.13683283
87* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.13447188
88KDM5A_27292631_Chip-Seq_BREAST_Human1.11900841
89TFEB_21752829_ChIP-Seq_HELA_Human1.10994665
90SOX2_18692474_ChIP-Seq_MEFs_Mouse1.10470113
91KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.09292146
92KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.09292146
93KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.09292146
94IRF1_19129219_ChIP-ChIP_H3396_Human1.06695821
95GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05935645
96STAT3_1855785_ChIP-Seq_MESCs_Mouse1.05450540
97* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.04996739
98* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.04719599
99BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04700026
100* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.04382313
101HIF1A_21447827_ChIP-Seq_MCF-7_Human1.03175032
102E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01532575
103DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.99643309
104NANOG_18692474_ChIP-Seq_MEFs_Mouse0.97937048
105IRF8_21731497_ChIP-ChIP_J774_Mouse0.95469125
106EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.95095874
107TP53_22573176_ChIP-Seq_HFKS_Human0.91568825
108SOX2_18555785_ChIP-Seq_MESCs_Mouse0.89269911
109HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.88509302
110RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.85607559
111PADI4_21655091_ChIP-ChIP_MCF-7_Human0.84797642
112ERG_20887958_ChIP-Seq_HPC-7_Mouse0.84568949
113* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.84394660
114NANOG_16153702_ChIP-ChIP_HESCs_Human0.84389660
115ELF5_23300383_ChIP-Seq_T47D_Human0.84374355
116CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.80990230
117SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.78612903
118SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.77229285
119SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.77229285
120* FLI1_27457419_Chip-Seq_LIVER_Mouse0.77089543
121HTT_18923047_ChIP-ChIP_STHdh_Human0.76846463
122NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.75052894
123SRY_22984422_ChIP-ChIP_TESTIS_Rat0.74005291
124CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.73138012
125SOX2_16153702_ChIP-ChIP_HESCs_Human0.73042797
126* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.71187410
127LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.67517633
128SALL4_22934838_ChIP-ChIP_CD34+_Human0.67206007
129NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.66802533
130TP63_19390658_ChIP-ChIP_HaCaT_Human0.66235295
131PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.66166865

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.37489405
2MP0008877_abnormal_DNA_methylation3.29827423
3MP0008438_abnormal_cutaneous_collagen3.11386962
4MP0003941_abnormal_skin_development2.78101310
5MP0003693_abnormal_embryo_hatching2.52916713
6MP0004272_abnormal_basement_membrane2.46643158
7MP0008057_abnormal_DNA_replication2.46172415
8MP0004957_abnormal_blastocyst_morpholog2.42286509
9MP0000750_abnormal_muscle_regeneration2.40596729
10MP0009379_abnormal_foot_pigmentation2.40395789
11MP0008932_abnormal_embryonic_tissue2.33319776
12MP0001986_abnormal_taste_sensitivity2.28792380
13MP0004084_abnormal_cardiac_muscle2.22369828
14MP0006036_abnormal_mitochondrial_physio2.22278764
15MP0005503_abnormal_tendon_morphology2.21999295
16MP0005623_abnormal_meninges_morphology2.19764286
17MP0003890_abnormal_embryonic-extraembry2.01550836
18MP0001542_abnormal_bone_strength1.95934802
19MP0005499_abnormal_olfactory_system1.90908275
20MP0005394_taste/olfaction_phenotype1.90908275
21MP0006035_abnormal_mitochondrial_morpho1.89306079
22MP0009250_abnormal_appendicular_skeleto1.87631459
23MP0005395_other_phenotype1.86165266
24MP0003279_aneurysm1.82247460
25MP0005275_abnormal_skin_tensile1.78950745
26MP0000749_muscle_degeneration1.77300843
27MP0010030_abnormal_orbit_morphology1.76292518
28MP0010352_gastrointestinal_tract_polyps1.76123112
29MP0002210_abnormal_sex_determination1.75970949
30MP0009333_abnormal_splenocyte_physiolog1.67785446
31MP0003186_abnormal_redox_activity1.67117638
32MP0001958_emphysema1.66584822
33MP0001929_abnormal_gametogenesis1.66332171
34MP0002282_abnormal_trachea_morphology1.65414903
35MP0003718_maternal_effect1.64784415
36MP0005023_abnormal_wound_healing1.61888521
37MP0000343_altered_response_to1.60950271
38MP0003950_abnormal_plasma_membrane1.60402540
39MP0003566_abnormal_cell_adhesion1.58209083
40MP0002160_abnormal_reproductive_system1.54363604
41MP0002102_abnormal_ear_morphology1.53767476
42MP0003077_abnormal_cell_cycle1.48883502
43MP0000751_myopathy1.48185185
44MP0001727_abnormal_embryo_implantation1.47662265
45MP0003646_muscle_fatigue1.43624165
46MP0001293_anophthalmia1.41958257
47MP0005380_embryogenesis_phenotype1.41412384
48MP0001672_abnormal_embryogenesis/_devel1.41412384
49MP0004036_abnormal_muscle_relaxation1.37964832
50MP0003385_abnormal_body_wall1.37550596
51MP0005075_abnormal_melanosome_morpholog1.34170704
52MP0003221_abnormal_cardiomyocyte_apopto1.31430938
53MP0000358_abnormal_cell_content/1.31189448
54MP0000653_abnormal_sex_gland1.30861984
55MP0002295_abnormal_pulmonary_circulatio1.29618561
56MP0009697_abnormal_copulation1.29159231
57MP0001145_abnormal_male_reproductive1.26875004
58MP0003724_increased_susceptibility_to1.26700796
59MP0005423_abnormal_somatic_nervous1.26339497
60MP0002148_abnormal_hypersensitivity_rea1.26191154
61MP0008004_abnormal_stomach_pH1.25725851
62MP0006072_abnormal_retinal_apoptosis1.25436542
63MP0008007_abnormal_cellular_replicative1.24351345
64MP0002127_abnormal_cardiovascular_syste1.24325354
65MP0008995_early_reproductive_senescence1.23823267
66MP0003123_paternal_imprinting1.21665392
67MP0000762_abnormal_tongue_morphology1.20710041
68MP0002163_abnormal_gland_morphology1.20258087
69MP0004134_abnormal_chest_morphology1.20151323
70MP0005330_cardiomyopathy1.19641211
71MP0000858_altered_metastatic_potential1.19474130
72MP0002972_abnormal_cardiac_muscle1.19307446
73MP0009384_cardiac_valve_regurgitation1.19041762
74MP0010094_abnormal_chromosome_stability1.18669906
75MP0003567_abnormal_fetal_cardiomyocyte1.18448650
76MP0001529_abnormal_vocalization1.17090925
77MP0002933_joint_inflammation1.16671686
78MP0003806_abnormal_nucleotide_metabolis1.15352598
79MP0002837_dystrophic_cardiac_calcinosis1.14796279
80MP0005410_abnormal_fertilization1.14710761
81MP0005508_abnormal_skeleton_morphology1.13012252
82MP0005164_abnormal_response_to1.12739212
83MP0003984_embryonic_growth_retardation1.11702213
84MP0003448_altered_tumor_morphology1.11626660
85MP0005389_reproductive_system_phenotype1.10867160
86MP0006138_congestive_heart_failure1.10739716
87MP0002088_abnormal_embryonic_growth/wei1.10411153
88MP0000049_abnormal_middle_ear1.09703484
89MP0002751_abnormal_autonomic_nervous1.09466816
90MP0003755_abnormal_palate_morphology1.09237359
91MP0009785_altered_susceptibility_to1.08454803
92MP0002085_abnormal_embryonic_tissue1.08022955
93MP0002084_abnormal_developmental_patter1.07919334
94MP0003699_abnormal_female_reproductive1.07881823
95MP0001544_abnormal_cardiovascular_syste1.06179895
96MP0005385_cardiovascular_system_phenoty1.06179895
97MP0001879_abnormal_lymphatic_vessel1.06105172
98MP0002132_abnormal_respiratory_system1.06061003
99MP0008775_abnormal_heart_ventricle1.05780907
100MP0005390_skeleton_phenotype1.05005293
101MP0002080_prenatal_lethality1.04993135
102MP0002106_abnormal_muscle_physiology1.04190611
103MP0000313_abnormal_cell_death1.04131600
104MP0002796_impaired_skin_barrier1.03907377
105MP0002277_abnormal_respiratory_mucosa1.03312023
106MP0001533_abnormal_skeleton_physiology1.01817434
107MP0004883_abnormal_blood_vessel1.01731366
108MP0005369_muscle_phenotype1.01151888
109MP0000759_abnormal_skeletal_muscle0.99855464
110MP0005408_hypopigmentation0.98797648
111MP0008260_abnormal_autophagy0.98794275
112MP0000733_abnormal_muscle_development0.97919222
113MP0005084_abnormal_gallbladder_morpholo0.97581301
114MP0004087_abnormal_muscle_fiber0.97081656
115MP0001119_abnormal_female_reproductive0.96709323
116MP0008789_abnormal_olfactory_epithelium0.96661671
117MP0003786_premature_aging0.95536412
118MP0003942_abnormal_urinary_system0.95269859
119MP0001764_abnormal_homeostasis0.95063565
120MP0000350_abnormal_cell_proliferation0.92546539
121MP0003091_abnormal_cell_migration0.92487031
122MP0003698_abnormal_male_reproductive0.91421268
123MP0000163_abnormal_cartilage_morphology0.90760979
124MP0002161_abnormal_fertility/fecundity0.90406329
125MP0002938_white_spotting0.89609198
126MP0005620_abnormal_muscle_contractility0.89408800
127MP0001730_embryonic_growth_arrest0.88745782
128MP0009053_abnormal_anal_canal0.87493226
129MP0000372_irregular_coat_pigmentation0.86895553
130MP0003119_abnormal_digestive_system0.86572190
131MP0001348_abnormal_lacrimal_gland0.85396328
132MP0005501_abnormal_skin_physiology0.84230712
133MP0010307_abnormal_tumor_latency0.83474586
134MP0001697_abnormal_embryo_size0.83124390
135MP0003111_abnormal_nucleus_morphology0.83113477
136MP0002113_abnormal_skeleton_development0.82039869
137MP0003122_maternal_imprinting0.81846514
138MP0002234_abnormal_pharynx_morphology0.81461933
139MP0001243_abnormal_dermal_layer0.80745360
140MP0008872_abnormal_physiological_respon0.78554518
141MP0003828_pulmonary_edema0.78549102
142MP0005646_abnormal_pituitary_gland0.77586622
143MP0004233_abnormal_muscle_weight0.77563535
144MP0002138_abnormal_hepatobiliary_system0.76571024
145MP0008058_abnormal_DNA_repair0.76518536
146MP0000647_abnormal_sebaceous_gland0.76315433
147MP0001299_abnormal_eye_distance/0.75690086
148MP0006054_spinal_hemorrhage0.75179541
149MP0004147_increased_porphyrin_level0.74570506
150MP0004215_abnormal_myocardial_fiber0.74468901
151MP0003121_genomic_imprinting0.73756415
152MP0002139_abnormal_hepatobiliary_system0.73575773
153MP0002233_abnormal_nose_morphology0.71698695
154MP0001984_abnormal_olfaction0.69952131
155MP0002086_abnormal_extraembryonic_tissu0.69588262
156MP0002638_abnormal_pupillary_reflex0.68410155
157MP0002090_abnormal_vision0.66837275
158MP0002095_abnormal_skin_pigmentation0.66751953
159MP0001853_heart_inflammation0.64555853
160MP0001286_abnormal_eye_development0.63309074
161MP0000631_abnormal_neuroendocrine_gland0.62897275
162MP0002396_abnormal_hematopoietic_system0.60251753
163MP0003936_abnormal_reproductive_system0.59356021
164MP0003195_calcinosis0.58992858
165MP0002019_abnormal_tumor_incidence0.58534961
166MP0005174_abnormal_tail_pigmentation0.58016439
167MP0003136_yellow_coat_color0.57974276
168MP0001881_abnormal_mammary_gland0.56536188

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.53994476
2Abnormal mitochondria in muscle tissue (HP:0008316)4.03409941
3Mitochondrial inheritance (HP:0001427)3.76987823
4Progressive macrocephaly (HP:0004481)3.55418056
5Abnormality of glycolysis (HP:0004366)3.50360241
6Increased serum pyruvate (HP:0003542)3.50360241
7Irregular epiphyses (HP:0010582)3.46877883
8Supernumerary spleens (HP:0009799)3.41485632
9Acute encephalopathy (HP:0006846)3.30897906
10Hepatocellular necrosis (HP:0001404)3.25920001
11Premature rupture of membranes (HP:0001788)3.24521319
12Increased CSF lactate (HP:0002490)3.22503554
13Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.10800902
14Aplastic anemia (HP:0001915)2.94523550
15Methylmalonic acidemia (HP:0002912)2.93756919
16Abnormality of cells of the erythroid lineage (HP:0012130)2.91222766
17Hepatic necrosis (HP:0002605)2.91132248
18Abnormal hemoglobin (HP:0011902)2.89678229
19Abnormality of the labia minora (HP:0012880)2.89518531
20Type I transferrin isoform profile (HP:0003642)2.85720362
21Microvesicular hepatic steatosis (HP:0001414)2.84457855
22Chromosomal breakage induced by crosslinking agents (HP:0003221)2.83478425
23Reticulocytopenia (HP:0001896)2.83319328
24Trismus (HP:0000211)2.82851625
25Meckel diverticulum (HP:0002245)2.80978649
26Abnormal lung lobation (HP:0002101)2.80296843
27Exercise intolerance (HP:0003546)2.70131601
28Abnormality of the ileum (HP:0001549)2.67994663
29Protrusio acetabuli (HP:0003179)2.67810745
30Respiratory failure (HP:0002878)2.65849293
31Chromsome breakage (HP:0040012)2.65276670
32Abnormality of methionine metabolism (HP:0010901)2.58503894
33Oral leukoplakia (HP:0002745)2.57722759
34Multiple enchondromatosis (HP:0005701)2.57376016
35Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.56080788
36Increased hepatocellular lipid droplets (HP:0006565)2.55211179
37Muscle fiber splitting (HP:0003555)2.54103032
38Cervical subluxation (HP:0003308)2.53947455
39Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.53923852
40Decreased activity of mitochondrial respiratory chain (HP:0008972)2.53923852
41Abnormality of the preputium (HP:0100587)2.53280146
42Parakeratosis (HP:0001036)2.53026172
43Methylmalonic aciduria (HP:0012120)2.50292029
44Short tibia (HP:0005736)2.48994287
45Epiphyseal dysplasia (HP:0002656)2.45591248
46Reduced antithrombin III activity (HP:0001976)2.44636091
47Nemaline bodies (HP:0003798)2.43808542
48Abnormality of dentin (HP:0010299)2.41877224
49Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.41030373
50Birth length less than 3rd percentile (HP:0003561)2.40846594
51Abnormality of the septum pellucidum (HP:0007375)2.40034816
52Glossoptosis (HP:0000162)2.39869301
53Abnormal number of erythroid precursors (HP:0012131)2.39042791
54Respiratory difficulties (HP:0002880)2.38338360
55Vertebral compression fractures (HP:0002953)2.38050800
56Single umbilical artery (HP:0001195)2.36212833
57Abnormality of the fetal cardiovascular system (HP:0010948)2.36212833
58Abnormal umbilical cord blood vessels (HP:0011403)2.36212833
59Calcaneovalgus deformity (HP:0001848)2.35819537
60Aplasia/Hypoplasia of the fovea (HP:0008060)2.34971969
61Hypoplasia of the fovea (HP:0007750)2.34971969
62Flat capital femoral epiphysis (HP:0003370)2.34481326
63Cerebral hypomyelination (HP:0006808)2.34421571
64Abnormality of aspartate family amino acid metabolism (HP:0010899)2.34130168
65Absent septum pellucidum (HP:0001331)2.32534074
66Distal lower limb muscle weakness (HP:0009053)2.32045549
67Horseshoe kidney (HP:0000085)2.32023266
68Macrocytic anemia (HP:0001972)2.29678370
69Lipid accumulation in hepatocytes (HP:0006561)2.27843073
70Vertebral hypoplasia (HP:0008417)2.27117290
71Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.27117290
72Median cleft lip (HP:0000161)2.26961564
73Muscle fiber inclusion bodies (HP:0100299)2.26836819
74Congenital, generalized hypertrichosis (HP:0004540)2.26000419
75Abnormality of placental membranes (HP:0011409)2.25792528
76Amniotic constriction ring (HP:0009775)2.25792528
77Breast hypoplasia (HP:0003187)2.25620055
78Aplasia/hypoplasia of the uterus (HP:0008684)2.25145429
79Deformed tarsal bones (HP:0008119)2.23950389
80Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.23557580
81Stenosis of the external auditory canal (HP:0000402)2.23367028
82Sparse eyelashes (HP:0000653)2.23258174
83Aplasia/Hypoplasia of the uvula (HP:0010293)2.23173980
843-Methylglutaconic aciduria (HP:0003535)2.22356707
85Glycosuria (HP:0003076)2.19968525
86Abnormality of urine glucose concentration (HP:0011016)2.19968525
87Abnormal spermatogenesis (HP:0008669)2.19678036
88Abnormal protein glycosylation (HP:0012346)2.18673208
89Abnormal glycosylation (HP:0012345)2.18673208
90Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.18673208
91Abnormal protein N-linked glycosylation (HP:0012347)2.18673208
92Congenital ichthyosiform erythroderma (HP:0007431)2.16734348
93Vitreoretinal degeneration (HP:0000655)2.16686063
94Abnormality of the calcaneus (HP:0008364)2.16621102
95Abnormality of abdominal situs (HP:0011620)2.14150754
96Abdominal situs inversus (HP:0003363)2.14150754
97Abnormality of chromosome stability (HP:0003220)2.13045457
98Premature ovarian failure (HP:0008209)2.11542009
99Posterior subcapsular cataract (HP:0007787)2.09380368
100Fibular aplasia (HP:0002990)2.09241305
101Aplasia/Hypoplasia of the tibia (HP:0005772)2.08682798
102Abnormality of the fovea (HP:0000493)2.08620739
103Abnormality of the umbilical cord (HP:0010881)2.07853016
104Myotonia (HP:0002486)2.07722189
105Spinal rigidity (HP:0003306)2.06937387
106Cleft eyelid (HP:0000625)2.06490017
107Aplasia/Hypoplasia involving the musculature (HP:0001460)2.05604715
108Pancytopenia (HP:0001876)2.05200442
109Colon cancer (HP:0003003)2.05188600
110Megaloblastic anemia (HP:0001889)2.04086998
111Increased serum lactate (HP:0002151)2.03724249
112Absent thumb (HP:0009777)2.03260894
113Azoospermia (HP:0000027)2.02627426
114Leukodystrophy (HP:0002415)2.02565023
115Lethargy (HP:0001254)2.01960137
116Pallor (HP:0000980)2.01279353
117Abnormality of renal resorption (HP:0011038)2.00322137
118Sensory axonal neuropathy (HP:0003390)2.00053352
119Exertional dyspnea (HP:0002875)1.99166371
120Fused cervical vertebrae (HP:0002949)1.98361776
121Absent radius (HP:0003974)1.97863825
122Duodenal stenosis (HP:0100867)1.96476702
123Small intestinal stenosis (HP:0012848)1.96476702
124Increased connective tissue (HP:0009025)1.96316028
125Abnormal pupillary function (HP:0007686)1.96249531
126Rough bone trabeculation (HP:0100670)1.95325816
127Cupped ribs (HP:0000887)1.95272843
128Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.95086165
129Abnormality of alanine metabolism (HP:0010916)1.95086165
130Hyperalaninemia (HP:0003348)1.95086165
131Hypoglycemic coma (HP:0001325)1.93578544
132Cerebral edema (HP:0002181)1.93491136
133Renal Fanconi syndrome (HP:0001994)1.91327890
134Septo-optic dysplasia (HP:0100842)1.87608664
135Wrist flexion contracture (HP:0001239)1.87521404
136Palpitations (HP:0001962)1.87151751
137Optic disc pallor (HP:0000543)1.86388855
138Ventricular tachycardia (HP:0004756)1.86060808
139Concave nail (HP:0001598)1.85294810
140Abnormalities of placenta or umbilical cord (HP:0001194)1.83748276
141Delayed epiphyseal ossification (HP:0002663)1.83329110
142Hypoplastic pelvis (HP:0008839)1.82609958
143Ulnar deviation of the wrist (HP:0003049)1.82519901
144Type 1 muscle fiber predominance (HP:0003803)1.82450928
145Autoamputation (HP:0001218)1.81556096
146Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.81515836
147Absent epiphyses (HP:0010577)1.81515836
148Small epiphyses (HP:0010585)1.80504990
149Carpal bone hypoplasia (HP:0001498)1.79690442
150Increased intramyocellular lipid droplets (HP:0012240)1.79521427
151Short nail (HP:0001799)1.78321729
152Rimmed vacuoles (HP:0003805)1.76627137
153Beaking of vertebral bodies (HP:0004568)1.75030713
154Right ventricular cardiomyopathy (HP:0011663)1.73202095
155Aplasia/Hypoplasia of the sacrum (HP:0008517)1.72721625
156Adrenal hypoplasia (HP:0000835)1.72087193
157Atrophic scars (HP:0001075)1.68641513
158Aplasia of the musculature (HP:0100854)1.68512404
159Genu varum (HP:0002970)1.68264234
160Soft skin (HP:0000977)1.67901883
161Lactic acidosis (HP:0003128)1.67807218
162Hypoplastic ischia (HP:0003175)1.67701742
163Neonatal short-limb short stature (HP:0008921)1.67266801
164Neck muscle weakness (HP:0000467)1.67156178

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LIMK14.26867824
2NME23.89679818
3VRK23.67467374
4NME13.38587781
5PIM23.03895904
6BUB12.97082736
7TESK12.92460516
8PBK2.54724205
9MYLK2.51047472
10TESK22.44836571
11MST42.43825790
12TTK2.33063609
13TRIM282.28899658
14EIF2AK12.09141322
15EPHA22.02449352
16STK161.86895121
17TTN1.76719990
18MKNK11.72546431
19TRPM71.64451744
20ERBB31.62198778
21ILK1.56331835
22TSSK61.45044345
23BCR1.43281540
24EIF2AK31.42599175
25WEE11.41362877
26MAP3K31.40290288
27TAOK31.40116393
28PIK3CA1.34386663
29OBSCN1.32692856
30SRPK11.31452545
31KDR1.30787438
32ARAF1.25206387
33RPS6KB21.23095180
34LRRK21.21448591
35STK38L1.20475433
36TNIK1.20312110
37DYRK21.12623708
38VRK11.10254577
39GRK71.04589190
40CCNB11.04149792
41MAPKAPK31.03442823
42CDK81.02938494
43CHEK21.01001304
44PAK10.98825127
45ZAK0.98387542
46MOS0.98214372
47LATS20.98157335
48ABL20.97099021
49PLK40.95274485
50OXSR10.91629776
51BRSK10.91293969
52STK40.91266923
53MAP3K90.90850187
54PLK30.90628341
55PAK40.89975809
56CDK90.89662044
57AURKA0.89459544
58STK100.89097625
59NEK90.88871214
60DDR20.88563569
61ACVR1B0.88497735
62STK240.86850482
63ROCK20.86366528
64PIK3CG0.86250246
65ROCK10.84299571
66RPS6KA40.83207055
67NEK60.81773895
68EIF2AK20.81623006
69ATR0.81048710
70CDK190.80620584
71PRKG20.80468029
72NUAK10.80417259
73WNK30.80136018
74BRSK20.80064989
75CHEK10.79298947
76TGFBR10.79216204
77PLK20.78337660
78EPHB20.78238566
79MAP4K20.76881899
80CSNK1G10.75329941
81BCKDK0.74596160
82STK390.73433235
83AURKB0.72876428
84NEK10.71153747
85ADRBK10.71093764
86PLK10.67925624
87INSRR0.67896373
88MAP3K120.65501319
89CDK70.65119827
90ADRBK20.65107352
91TIE10.64822101
92PAK30.64564755
93DAPK30.62897821
94PAK20.61557601
95STK30.60898493
96TAF10.59022933
97MUSK0.58923706
98RAF10.58284467
99CSNK2A10.56596788
100MAPKAPK20.56012660
101ATM0.55963381
102SIK30.54253815
103PRKCI0.53729872
104PNCK0.52876060
105WNK40.52481657
106NEK20.52235917
107TLK10.50941411
108GRK10.50892082
109SCYL20.48470387
110MAP3K140.46355042
111CSNK1G20.46336124
112BMPR20.46264070
113IKBKB0.44054334
114CSNK1E0.41817327
115RPS6KA50.41600130
116DYRK30.41526896
117MAP2K10.41001538
118PIM10.40969839
119MAPKAPK50.40904400
120BRAF0.40678785
121CASK0.40597843
122ERBB40.40524765
123CSNK2A20.40472425
124PDK20.39510497
125CDC70.39488664
126CDK140.39446378
127MET0.39280126
128CDK10.37283565
129MAP3K80.36680882
130BMPR1B0.36169331
131CDK20.35790757
132AKT20.33301210
133MARK30.32906131
134CSNK1G30.30987655
135MELK0.30881463
136MAP3K110.29280799
137CLK10.28417318
138MKNK20.27250576
139IRAK40.26248967
140CSNK1A1L0.26210421
141TXK0.26185520
142DAPK10.25802973
143PRKACB0.25788779

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.13345915
2Ribosome_Homo sapiens_hsa030104.56985075
3Oxidative phosphorylation_Homo sapiens_hsa001903.80879708
4Parkinsons disease_Homo sapiens_hsa050123.41745066
5RNA polymerase_Homo sapiens_hsa030202.85565908
6Protein export_Homo sapiens_hsa030602.55511345
7Huntingtons disease_Homo sapiens_hsa050162.53831342
8Alzheimers disease_Homo sapiens_hsa050102.34619966
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.13784678
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.05023589
11Spliceosome_Homo sapiens_hsa030402.02088493
12DNA replication_Homo sapiens_hsa030301.91876184
13Folate biosynthesis_Homo sapiens_hsa007901.89759242
14Fanconi anemia pathway_Homo sapiens_hsa034601.85293973
15Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.84400181
16Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.82614806
17Pyrimidine metabolism_Homo sapiens_hsa002401.75833146
18Cardiac muscle contraction_Homo sapiens_hsa042601.68901591
19Nucleotide excision repair_Homo sapiens_hsa034201.65169014
20Graft-versus-host disease_Homo sapiens_hsa053321.60658648
21Cysteine and methionine metabolism_Homo sapiens_hsa002701.52006906
22Mismatch repair_Homo sapiens_hsa034301.50768696
23RNA transport_Homo sapiens_hsa030131.49112506
24Basal transcription factors_Homo sapiens_hsa030221.48131683
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.41638920
26Homologous recombination_Homo sapiens_hsa034401.36149209
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.30262570
28Base excision repair_Homo sapiens_hsa034101.29260995
29mRNA surveillance pathway_Homo sapiens_hsa030151.24200765
30Oocyte meiosis_Homo sapiens_hsa041141.22282569
31Cell cycle_Homo sapiens_hsa041101.18370247
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.18349523
33Viral myocarditis_Homo sapiens_hsa054161.18313713
34Propanoate metabolism_Homo sapiens_hsa006401.18100573
35Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.17692812
36Allograft rejection_Homo sapiens_hsa053301.14014495
37Legionellosis_Homo sapiens_hsa051341.14007199
38Regulation of autophagy_Homo sapiens_hsa041401.13707964
39Rheumatoid arthritis_Homo sapiens_hsa053231.13589618
40Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.10693004
41p53 signaling pathway_Homo sapiens_hsa041151.08181673
42Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.06523296
43ECM-receptor interaction_Homo sapiens_hsa045121.04011452
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.02901209
45Glutathione metabolism_Homo sapiens_hsa004801.00976654
46Pyruvate metabolism_Homo sapiens_hsa006201.00147645
47Epstein-Barr virus infection_Homo sapiens_hsa051690.98534600
48Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.96970219
49Phagosome_Homo sapiens_hsa041450.96183621
50Purine metabolism_Homo sapiens_hsa002300.95831211
51Dilated cardiomyopathy_Homo sapiens_hsa054140.95219629
52Vibrio cholerae infection_Homo sapiens_hsa051100.95166904
53Non-homologous end-joining_Homo sapiens_hsa034500.90696310
54Sulfur metabolism_Homo sapiens_hsa009200.87071904
55Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.85922140
56Malaria_Homo sapiens_hsa051440.85715504
57Selenocompound metabolism_Homo sapiens_hsa004500.81886785
58Arachidonic acid metabolism_Homo sapiens_hsa005900.81193125
59Shigellosis_Homo sapiens_hsa051310.79323138
60RNA degradation_Homo sapiens_hsa030180.77511996
61SNARE interactions in vesicular transport_Homo sapiens_hsa041300.76356352
62Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.76262622
63Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.71517939
64TGF-beta signaling pathway_Homo sapiens_hsa043500.70994775
65Autoimmune thyroid disease_Homo sapiens_hsa053200.70789054
66One carbon pool by folate_Homo sapiens_hsa006700.68926513
67Antigen processing and presentation_Homo sapiens_hsa046120.64689138
68Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.63114728
69Caffeine metabolism_Homo sapiens_hsa002320.62937361
70Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.61331444
71Apoptosis_Homo sapiens_hsa042100.57477603
72Focal adhesion_Homo sapiens_hsa045100.56971518
73Tight junction_Homo sapiens_hsa045300.56950275
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56257329
75Salmonella infection_Homo sapiens_hsa051320.55958739
76Drug metabolism - other enzymes_Homo sapiens_hsa009830.54537263
77Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.53087156
78Steroid biosynthesis_Homo sapiens_hsa001000.52179475
79Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.52012333
80Peroxisome_Homo sapiens_hsa041460.50750309
81NOD-like receptor signaling pathway_Homo sapiens_hsa046210.50426314
82Hippo signaling pathway_Homo sapiens_hsa043900.50354920
83Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.50334229
84Hematopoietic cell lineage_Homo sapiens_hsa046400.49910585
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.49006196
86Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.48930788
87Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48633365
88Leukocyte transendothelial migration_Homo sapiens_hsa046700.47818015
89Collecting duct acid secretion_Homo sapiens_hsa049660.47404717
90Asthma_Homo sapiens_hsa053100.47153463
91Pertussis_Homo sapiens_hsa051330.44990007
92Type I diabetes mellitus_Homo sapiens_hsa049400.43338144
93Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43032003
94Small cell lung cancer_Homo sapiens_hsa052220.42728151
95PI3K-Akt signaling pathway_Homo sapiens_hsa041510.42653911
96Leishmaniasis_Homo sapiens_hsa051400.42037601
97Phototransduction_Homo sapiens_hsa047440.41645681
98Intestinal immune network for IgA production_Homo sapiens_hsa046720.40216576
99HIF-1 signaling pathway_Homo sapiens_hsa040660.39355399
100Amoebiasis_Homo sapiens_hsa051460.39174019
101Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38808797
102MicroRNAs in cancer_Homo sapiens_hsa052060.38154528
103Bladder cancer_Homo sapiens_hsa052190.37503961
104HTLV-I infection_Homo sapiens_hsa051660.36592855
105Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.35124020
106Viral carcinogenesis_Homo sapiens_hsa052030.35078826
107Proteoglycans in cancer_Homo sapiens_hsa052050.34026946
108Vitamin B6 metabolism_Homo sapiens_hsa007500.33115648
109Biosynthesis of amino acids_Homo sapiens_hsa012300.32993041
110AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.32360999
111NF-kappa B signaling pathway_Homo sapiens_hsa040640.30715233
112Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.29959985
113Vitamin digestion and absorption_Homo sapiens_hsa049770.28919353
114Maturity onset diabetes of the young_Homo sapiens_hsa049500.28835144
115Metabolic pathways_Homo sapiens_hsa011000.28594940
116Melanoma_Homo sapiens_hsa052180.28480249
117Sphingolipid metabolism_Homo sapiens_hsa006000.27837500
118Galactose metabolism_Homo sapiens_hsa000520.27558001
119Fatty acid elongation_Homo sapiens_hsa000620.27313042
120Herpes simplex infection_Homo sapiens_hsa051680.26967018
121Adherens junction_Homo sapiens_hsa045200.26804061
122Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.26761416
123Arginine and proline metabolism_Homo sapiens_hsa003300.25944732
124Pathways in cancer_Homo sapiens_hsa052000.25829678
1252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.25763584
126Measles_Homo sapiens_hsa051620.25687207
127N-Glycan biosynthesis_Homo sapiens_hsa005100.24971895
128Other glycan degradation_Homo sapiens_hsa005110.24377786
129Protein digestion and absorption_Homo sapiens_hsa049740.23962433
130Pentose and glucuronate interconversions_Homo sapiens_hsa000400.23383799
131Butanoate metabolism_Homo sapiens_hsa006500.22951202
132Carbon metabolism_Homo sapiens_hsa012000.21824038
133Circadian rhythm_Homo sapiens_hsa047100.21296394
134Sulfur relay system_Homo sapiens_hsa041220.19934503
135Nitrogen metabolism_Homo sapiens_hsa009100.16479397
136beta-Alanine metabolism_Homo sapiens_hsa004100.15997158
137Fatty acid metabolism_Homo sapiens_hsa012120.15818931
138Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.15730154
139Pentose phosphate pathway_Homo sapiens_hsa000300.15642140
140Chemical carcinogenesis_Homo sapiens_hsa052040.11580570
141Synaptic vesicle cycle_Homo sapiens_hsa047210.09755248
142Olfactory transduction_Homo sapiens_hsa047400.09313821
143Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.09278814
144Wnt signaling pathway_Homo sapiens_hsa043100.07288074
145Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.06334322
146Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.04946499
147Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.02692471
148Primary bile acid biosynthesis_Homo sapiens_hsa001200.01372920
149Tryptophan metabolism_Homo sapiens_hsa003800.00785856
150Retinol metabolism_Homo sapiens_hsa008300.00655424

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