PDCD5P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chaperone-mediated protein transport (GO:0072321)7.41190850
2ribosomal small subunit biogenesis (GO:0042274)6.71138569
3ATP synthesis coupled proton transport (GO:0015986)6.27903425
4energy coupled proton transport, down electrochemical gradient (GO:0015985)6.27903425
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.20524267
6mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.05979603
7viral transcription (GO:0019083)5.86249018
8translational termination (GO:0006415)5.71578232
9maturation of SSU-rRNA (GO:0030490)5.62218744
10protein complex biogenesis (GO:0070271)5.52023304
11mitochondrial respiratory chain complex I assembly (GO:0032981)5.50148589
12NADH dehydrogenase complex assembly (GO:0010257)5.50148589
13mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.50148589
14GTP biosynthetic process (GO:0006183)5.48106937
15respiratory electron transport chain (GO:0022904)5.39346705
16electron transport chain (GO:0022900)5.35896434
17protein neddylation (GO:0045116)5.22194815
18mitochondrial respiratory chain complex assembly (GO:0033108)5.21872940
19SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.19268192
20cotranslational protein targeting to membrane (GO:0006613)5.11870352
21ribosomal small subunit assembly (GO:0000028)5.06738797
22translational elongation (GO:0006414)5.04637659
23protein targeting to ER (GO:0045047)5.03898781
24proteasome assembly (GO:0043248)4.93301174
25UTP biosynthetic process (GO:0006228)4.85351918
26establishment of protein localization to endoplasmic reticulum (GO:0072599)4.77907746
27protein localization to endoplasmic reticulum (GO:0070972)4.73534429
28establishment of protein localization to mitochondrial membrane (GO:0090151)4.50021062
29UTP metabolic process (GO:0046051)4.48697380
30cellular protein complex disassembly (GO:0043624)4.42435260
31guanosine-containing compound biosynthetic process (GO:1901070)4.33617937
32purine ribonucleoside triphosphate biosynthetic process (GO:0009206)4.28192208
33pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.25971468
34viral life cycle (GO:0019058)4.25327063
35nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.24619225
36ribosomal large subunit biogenesis (GO:0042273)4.24249876
37purine nucleoside triphosphate biosynthetic process (GO:0009145)4.20192726
38CTP biosynthetic process (GO:0006241)4.19818889
39CTP metabolic process (GO:0046036)4.19818889
40protein-cofactor linkage (GO:0018065)4.14760951
41deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.11211767
42translation (GO:0006412)4.10646841
43tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.98314691
44RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.98314691
45regulation of mitochondrial translation (GO:0070129)3.96027977
46respiratory chain complex IV assembly (GO:0008535)3.94789601
47pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.92368881
48translational initiation (GO:0006413)3.92011725
49ATP biosynthetic process (GO:0006754)3.90324399
50pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.88957374
51water-soluble vitamin biosynthetic process (GO:0042364)3.87873187
52ribonucleoside triphosphate biosynthetic process (GO:0009201)3.87527499
53pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.81622933
54cellular component biogenesis (GO:0044085)3.76833198
55termination of RNA polymerase III transcription (GO:0006386)3.72160658
56transcription elongation from RNA polymerase III promoter (GO:0006385)3.72160658
57rRNA modification (GO:0000154)3.72009755
58protein deneddylation (GO:0000338)3.69487240
59protein complex disassembly (GO:0043241)3.63207627
60peptidyl-histidine modification (GO:0018202)3.62600491
61cytochrome complex assembly (GO:0017004)3.60181514
62pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.60073746
63pyrimidine nucleotide catabolic process (GO:0006244)3.59563429
64hydrogen ion transmembrane transport (GO:1902600)3.57426271
65protein targeting to mitochondrion (GO:0006626)3.55265913
66macromolecular complex disassembly (GO:0032984)3.48003391
67ribonucleoprotein complex biogenesis (GO:0022613)3.36947753
68nucleoside triphosphate biosynthetic process (GO:0009142)3.34371899
69cullin deneddylation (GO:0010388)3.32422770
70inner mitochondrial membrane organization (GO:0007007)3.30265639
71protein localization to mitochondrion (GO:0070585)3.25438280
72establishment of protein localization to mitochondrion (GO:0072655)3.24590304
73protein targeting to membrane (GO:0006612)3.23313566
74exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.23156286
75kinetochore assembly (GO:0051382)3.22875200
76nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.22235391
77pseudouridine synthesis (GO:0001522)3.20798512
78DNA deamination (GO:0045006)3.20022923
79iron-sulfur cluster assembly (GO:0016226)3.20015466
80metallo-sulfur cluster assembly (GO:0031163)3.20015466
81pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.19200560
82spliceosomal snRNP assembly (GO:0000387)3.10718074
83proton transport (GO:0015992)3.10229519
84hydrogen transport (GO:0006818)3.05190358
85nuclear-transcribed mRNA catabolic process (GO:0000956)3.05103028
86nucleoside diphosphate phosphorylation (GO:0006165)3.04067290
87pyrimidine ribonucleoside biosynthetic process (GO:0046132)3.02581034
88rRNA processing (GO:0006364)3.01572262
89pyrimidine nucleotide biosynthetic process (GO:0006221)2.97846405
90DNA damage response, detection of DNA damage (GO:0042769)2.93833879
91tRNA processing (GO:0008033)2.92072164
92negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.90807333
93kinetochore organization (GO:0051383)2.89501437
94mRNA catabolic process (GO:0006402)2.87755090
95rRNA metabolic process (GO:0016072)2.86435356
96detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.85663691
97purine nucleotide salvage (GO:0032261)2.85158439
98pyrimidine ribonucleotide biosynthetic process (GO:0009220)2.84489088
99ubiquinone biosynthetic process (GO:0006744)2.82673118
100purine nucleoside biosynthetic process (GO:0042451)2.76716648

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.93516105
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.85039851
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.38222293
4ELF1_17652178_ChIP-ChIP_JURKAT_Human4.33247549
5GABP_17652178_ChIP-ChIP_JURKAT_Human4.04719167
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.76071439
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.75957558
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.50700038
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.36224358
10MYC_18555785_ChIP-Seq_MESCs_Mouse3.35305939
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.31525040
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.25880762
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.24609400
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.86790157
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.76523021
16VDR_23849224_ChIP-Seq_CD4+_Human2.59945072
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.40702247
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.39210636
19EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.38934592
20EZH2_22144423_ChIP-Seq_EOC_Human2.33414774
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.30040882
22FOXP3_21729870_ChIP-Seq_TREG_Human2.27054521
23XRN2_22483619_ChIP-Seq_HELA_Human2.21469085
24RBPJ_22232070_ChIP-Seq_NCS_Mouse2.12646994
25DCP1A_22483619_ChIP-Seq_HELA_Human2.09569981
26GABP_19822575_ChIP-Seq_HepG2_Human2.07811244
27PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.03866295
28THAP11_20581084_ChIP-Seq_MESCs_Mouse2.01400025
29SRF_21415370_ChIP-Seq_HL-1_Mouse2.01266798
30ELK1_19687146_ChIP-ChIP_HELA_Human1.98826983
31MYC_19030024_ChIP-ChIP_MESCs_Mouse1.94554930
32E2F1_18555785_ChIP-Seq_MESCs_Mouse1.81173267
33TTF2_22483619_ChIP-Seq_HELA_Human1.70640242
34NOTCH1_21737748_ChIP-Seq_TLL_Human1.68567426
35CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.68216855
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67261928
37MYC_18940864_ChIP-ChIP_HL60_Human1.64950491
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.58207824
39ZNF274_21170338_ChIP-Seq_K562_Hela1.58202804
40ZNF263_19887448_ChIP-Seq_K562_Human1.57790003
41ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.57766356
42MYC_19079543_ChIP-ChIP_MESCs_Mouse1.50486472
43E2F4_17652178_ChIP-ChIP_JURKAT_Human1.46271563
44YY1_21170310_ChIP-Seq_MESCs_Mouse1.42394623
45ELK1_22589737_ChIP-Seq_MCF10A_Human1.39040280
46FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.34520463
47CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.28462131
48POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.25465830
49VDR_22108803_ChIP-Seq_LS180_Human1.22097917
50BP1_19119308_ChIP-ChIP_Hs578T_Human1.21691501
51NELFA_20434984_ChIP-Seq_ESCs_Mouse1.19826237
52HOXB4_20404135_ChIP-ChIP_EML_Mouse1.16265609
53TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.16035046
54TP53_22573176_ChIP-Seq_HFKS_Human1.14891465
55TP63_19390658_ChIP-ChIP_HaCaT_Human1.12931584
56DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.12084733
57SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.08862827
58SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.04248738
59KDM5A_27292631_Chip-Seq_BREAST_Human1.03855445
60IRF1_19129219_ChIP-ChIP_H3396_Human1.03632842
61YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03067887
62KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.01977668
63EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.01946613
64MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.98421888
65FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.97667794
66POU5F1_16153702_ChIP-ChIP_HESCs_Human0.97599508
67BMI1_23680149_ChIP-Seq_NPCS_Mouse0.96607702
68LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93711489
69CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.93468833
70SOX2_16153702_ChIP-ChIP_HESCs_Human0.91488280
71GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.90463061
72AR_20517297_ChIP-Seq_VCAP_Human0.90430689
73TAF2_19829295_ChIP-Seq_ESCs_Human0.89663893
74SOX2_18555785_ChIP-Seq_MESCs_Mouse0.89514842
75PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.89021039
76CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.88630270
77FLI1_27457419_Chip-Seq_LIVER_Mouse0.88002844
78CIITA_25753668_ChIP-Seq_RAJI_Human0.87689408
79CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.87551085
80CTCF_18555785_ChIP-Seq_MESCs_Mouse0.86996622
81RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.86827907
82SRY_22984422_ChIP-ChIP_TESTIS_Rat0.86580690
83BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.86486561
84HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.85824933
85FOXP1_21924763_ChIP-Seq_HESCs_Human0.84599673
86POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.84426063
87KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.84345741
88KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.84345741
89KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.84345741
90ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.83878373
91PCGF2_27294783_Chip-Seq_ESCs_Mouse0.82316014
92MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.81571119
93EWS_26573619_Chip-Seq_HEK293_Human0.79977130
94CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.79815936
95NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.79502207
96PADI4_21655091_ChIP-ChIP_MCF-7_Human0.78731301
97EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.76983583
98PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.74960946
99BCL6_27268052_Chip-Seq_Bcells_Human0.74706274
100FOXA1_27270436_Chip-Seq_PROSTATE_Human0.74228048

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.05802362
2MP0006292_abnormal_olfactory_placode4.81214060
3MP0004147_increased_porphyrin_level4.23185028
4MP0008789_abnormal_olfactory_epithelium3.47129967
5MP0005394_taste/olfaction_phenotype3.05471421
6MP0005499_abnormal_olfactory_system3.05471421
7MP0005671_abnormal_response_to2.88377620
8MP0002234_abnormal_pharynx_morphology2.57293617
9MP0002102_abnormal_ear_morphology2.47631955
10MP0001529_abnormal_vocalization2.27452781
11MP0000372_irregular_coat_pigmentation2.17427983
12MP0000049_abnormal_middle_ear2.16156880
13MP0008058_abnormal_DNA_repair1.92695410
14MP0005646_abnormal_pituitary_gland1.87940979
15MP0004145_abnormal_muscle_electrophysio1.80096236
16MP0008877_abnormal_DNA_methylation1.71589835
17MP0002277_abnormal_respiratory_mucosa1.70763352
18MP0005551_abnormal_eye_electrophysiolog1.69846340
19MP0003786_premature_aging1.67210439
20MP0003880_abnormal_central_pattern1.66666458
21MP0003878_abnormal_ear_physiology1.64898721
22MP0005377_hearing/vestibular/ear_phenot1.64898721
23MP0001905_abnormal_dopamine_level1.63861753
24MP0002090_abnormal_vision1.62353174
25MP0002938_white_spotting1.62145338
26MP0006036_abnormal_mitochondrial_physio1.59000310
27MP0001188_hyperpigmentation1.58572397
28MP0002638_abnormal_pupillary_reflex1.56667596
29MP0001293_anophthalmia1.45322555
30MP0003693_abnormal_embryo_hatching1.39932958
31MP0002736_abnormal_nociception_after1.39404961
32MP0010030_abnormal_orbit_morphology1.39330349
33MP0003011_delayed_dark_adaptation1.38708824
34MP0004142_abnormal_muscle_tone1.35988734
35MP0002163_abnormal_gland_morphology1.32426438
36MP0002653_abnormal_ependyma_morphology1.31646321
37MP0008932_abnormal_embryonic_tissue1.31041100
38MP0006072_abnormal_retinal_apoptosis1.30753553
39MP0002837_dystrophic_cardiac_calcinosis1.30214815
40MP0003866_abnormal_defecation1.29757863
41MP0008995_early_reproductive_senescence1.28573828
42MP0003186_abnormal_redox_activity1.26675579
43MP0002160_abnormal_reproductive_system1.23528964
44MP0005645_abnormal_hypothalamus_physiol1.22388950
45MP0000566_synostosis1.18325172
46MP0003879_abnormal_hair_cell1.18217185
47MP0009053_abnormal_anal_canal1.17697169
48MP0003763_abnormal_thymus_physiology1.14853742
49MP0003567_abnormal_fetal_cardiomyocyte1.14465294
50MP0005084_abnormal_gallbladder_morpholo1.12205362
51MP0008875_abnormal_xenobiotic_pharmacok1.10900988
52MP0001984_abnormal_olfaction1.10527012
53MP0005253_abnormal_eye_physiology1.08246041
54MP0003111_abnormal_nucleus_morphology1.07452430
55MP0001270_distended_abdomen1.06331236
56MP0003195_calcinosis1.06022262
57MP0000026_abnormal_inner_ear1.04164506
58MP0001485_abnormal_pinna_reflex1.00109171
59MP0005195_abnormal_posterior_eye0.99278067
60MP0001986_abnormal_taste_sensitivity0.97190361
61MP0003315_abnormal_perineum_morphology0.96747053
62MP0002233_abnormal_nose_morphology0.95498835
63MP0002184_abnormal_innervation0.95443076
64MP0002095_abnormal_skin_pigmentation0.94476845
65MP0004858_abnormal_nervous_system0.93930315
66MP0001764_abnormal_homeostasis0.93355523
67MP0005075_abnormal_melanosome_morpholog0.93114613
68MP0001486_abnormal_startle_reflex0.93079759
69MP0005360_urolithiasis0.92964320
70MP0003938_abnormal_ear_development0.91705638
71MP0001919_abnormal_reproductive_system0.90044506
72MP0005379_endocrine/exocrine_gland_phen0.89587986
73MP0001968_abnormal_touch/_nociception0.89313983
74MP0010094_abnormal_chromosome_stability0.88488985
75MP0000678_abnormal_parathyroid_gland0.88310457
76MP0001963_abnormal_hearing_physiology0.86681302
77MP0002752_abnormal_somatic_nervous0.86021143
78MP0002876_abnormal_thyroid_physiology0.83557751
79MP0002210_abnormal_sex_determination0.83285853
80MP0002177_abnormal_outer_ear0.82077785
81MP0005389_reproductive_system_phenotype0.81391025
82MP0000631_abnormal_neuroendocrine_gland0.78060224
83MP0001346_abnormal_lacrimal_gland0.76904326
84MP0003137_abnormal_impulse_conducting0.75574841
85MP0004885_abnormal_endolymph0.74156241
86MP0009745_abnormal_behavioral_response0.72668619
87MP0003119_abnormal_digestive_system0.71675349
88MP0003718_maternal_effect0.71145591
89MP0005332_abnormal_amino_acid0.66228927
90MP0000647_abnormal_sebaceous_gland0.65478187
91MP0005391_vision/eye_phenotype0.65164090
92MP0003122_maternal_imprinting0.64271236
93MP0003755_abnormal_palate_morphology0.63108710
94MP0006035_abnormal_mitochondrial_morpho0.62494171
95MP0005647_abnormal_sex_gland0.62347179
96MP0002572_abnormal_emotion/affect_behav0.61428464
97MP0005365_abnormal_bile_salt0.61293422
98MP0008872_abnormal_physiological_respon0.61012961
99MP0000653_abnormal_sex_gland0.59875737
100MP0003646_muscle_fatigue0.59861982

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.65497103
2Abnormal mitochondria in muscle tissue (HP:0008316)5.46214434
3Mitochondrial inheritance (HP:0001427)4.97225541
4Acute encephalopathy (HP:0006846)4.87111122
5Progressive macrocephaly (HP:0004481)4.58525587
6Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.47591582
7Decreased activity of mitochondrial respiratory chain (HP:0008972)4.47591582
8Increased CSF lactate (HP:0002490)4.45817499
9Renal Fanconi syndrome (HP:0001994)4.43432758
10Hepatocellular necrosis (HP:0001404)4.00026528
11Increased intramyocellular lipid droplets (HP:0012240)3.85372166
12Increased hepatocellular lipid droplets (HP:0006565)3.82668558
13Cerebral edema (HP:0002181)3.61017268
14Hepatic necrosis (HP:0002605)3.53792960
15Absent rod-and cone-mediated responses on ERG (HP:0007688)3.46253100
16Macrocytic anemia (HP:0001972)3.42091644
17Testicular atrophy (HP:0000029)3.25937976
18Lipid accumulation in hepatocytes (HP:0006561)3.22409030
193-Methylglutaconic aciduria (HP:0003535)3.21670071
20Lactic acidosis (HP:0003128)3.21232529
21Increased muscle lipid content (HP:0009058)3.10413148
22Increased serum lactate (HP:0002151)3.09881174
23Respiratory failure (HP:0002878)2.95480557
24Abnormal number of erythroid precursors (HP:0012131)2.89188764
25Abnormality of cells of the erythroid lineage (HP:0012130)2.88351007
26Generalized aminoaciduria (HP:0002909)2.87940275
27Aplastic anemia (HP:0001915)2.66728095
28Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.65887027
29Exercise intolerance (HP:0003546)2.65159383
30Abnormal rod and cone electroretinograms (HP:0008323)2.63249656
31Abnormality of renal resorption (HP:0011038)2.57657090
32Leukodystrophy (HP:0002415)2.52551822
33Abnormality of alanine metabolism (HP:0010916)2.51714460
34Hyperalaninemia (HP:0003348)2.51714460
35Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.51714460
36Molar tooth sign on MRI (HP:0002419)2.49848058
37Abnormality of midbrain morphology (HP:0002418)2.49848058
38Abnormality of urine glucose concentration (HP:0011016)2.46784178
39Glycosuria (HP:0003076)2.46784178
40Reticulocytopenia (HP:0001896)2.42803443
41Renal cortical cysts (HP:0000803)2.42632701
42Exertional dyspnea (HP:0002875)2.40917982
43Asplenia (HP:0001746)2.39176682
44Optic disc pallor (HP:0000543)2.37952220
45Lethargy (HP:0001254)2.33982473
46Pancytopenia (HP:0001876)2.29113252
47Aplasia/Hypoplasia of the spleen (HP:0010451)2.27650872
48Dyschromatopsia (HP:0007641)2.20438888
49Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.17589066
50Autoimmune hemolytic anemia (HP:0001890)2.17523381
51Hypoplastic pelvis (HP:0008839)2.13734297
52Hyperglycinemia (HP:0002154)2.12207057
53Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.11163500
54Autoimmune thrombocytopenia (HP:0001973)2.08655581
55Gout (HP:0001997)2.07723511
56Aplasia/Hypoplasia of the sacrum (HP:0008517)2.06064746
57Microretrognathia (HP:0000308)2.05644749
58Abnormal drinking behavior (HP:0030082)2.05172403
59Polydipsia (HP:0001959)2.05172403
60Abolished electroretinogram (ERG) (HP:0000550)2.03470472
61Septo-optic dysplasia (HP:0100842)2.01917699
62Increased serum pyruvate (HP:0003542)2.01824460
63Visual hallucinations (HP:0002367)2.01520003
64Pallor (HP:0000980)1.99337437
65Abnormality of the renal cortex (HP:0011035)1.98870879
66Methylmalonic acidemia (HP:0002912)1.95454831
67Medial flaring of the eyebrow (HP:0010747)1.94384572
68CNS demyelination (HP:0007305)1.93038844
69Triphalangeal thumb (HP:0001199)1.92396437
70Hyperphosphaturia (HP:0003109)1.92193177
71Constricted visual fields (HP:0001133)1.91997044
72Male infertility (HP:0003251)1.91636514
73Congenital stationary night blindness (HP:0007642)1.88533620
74Pancreatic cysts (HP:0001737)1.88258631
75Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.85527978
76Microvesicular hepatic steatosis (HP:0001414)1.85151234
77X-linked dominant inheritance (HP:0001423)1.84540627
78Opisthotonus (HP:0002179)1.82973257
79Spastic paraparesis (HP:0002313)1.82536891
80Myokymia (HP:0002411)1.81805629
81Parakeratosis (HP:0001036)1.80185266
82Polyuria (HP:0000103)1.77639213
83Type 2 muscle fiber atrophy (HP:0003554)1.76325833
84Hypoplastic left heart (HP:0004383)1.75218321
85Chronic bronchitis (HP:0004469)1.72659458
86Renal dysplasia (HP:0000110)1.71802754
87Decreased electroretinogram (ERG) amplitude (HP:0000654)1.71227945
88Methylmalonic aciduria (HP:0012120)1.70347400
89Absent thumb (HP:0009777)1.69171056
90Hypophosphatemic rickets (HP:0004912)1.68415082
91Forearm undergrowth (HP:0009821)1.67299209
92Increased neuronal autofluorescent lipopigment (HP:0002074)1.67134212
93Severe combined immunodeficiency (HP:0004430)1.66723849
94Failure to thrive in infancy (HP:0001531)1.66426410
95Abnormal respiratory motile cilium physiology (HP:0012261)1.64764509
96Muscle fiber atrophy (HP:0100295)1.64187984
97Respiratory difficulties (HP:0002880)1.63702209
98Ragged-red muscle fibers (HP:0003200)1.63496417
99Amniotic constriction ring (HP:0009775)1.62652859
100Abnormality of placental membranes (HP:0011409)1.62652859

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK24.84787913
2NME24.31464724
3STK163.28142834
4TXK2.72980485
5LIMK12.45316457
6BUB12.45050324
7MAP4K12.31726683
8TIE12.23411967
9KDR2.14871413
10VRK22.03132432
11ADRBK21.97415770
12GRK11.95285757
13TRIM281.95032496
14BCKDK1.85013444
15NME11.83040556
16TESK11.70719586
17NEK11.65584154
18MAP4K21.58524740
19LRRK21.47439082
20ARAF1.45140993
21TEC1.37586323
22SRPK11.37536315
23PLK41.37315139
24MAP3K91.37029505
25CDK81.22750369
26MAPKAPK31.18118634
27PDK21.13845669
28PASK1.12883131
29EPHA41.10072719
30MAP2K71.09644490
31WNK31.08510666
32BCR1.06377333
33DYRK21.04581865
34CSNK1G31.04392047
35CCNB11.03830359
36CSNK1G21.02821048
37MAP3K111.01103080
38VRK11.01074125
39PIK3CA0.96504884
40WNK40.93393190
41ITK0.90089578
42TLK10.88804558
43MAP3K40.87312957
44SCYL20.85387189
45PIM20.84585482
46ABL20.83760641
47TSSK60.82880412
48DMPK0.81949629
49BRAF0.81019275
50ZAK0.80142380
51INSRR0.79659485
52RPS6KA50.79602223
53MUSK0.78273152
54CSNK1G10.75379947
55CSNK2A10.73531311
56CSNK1A1L0.70646277
57CAMKK20.70096670
58MST40.69759116
59AURKA0.69371370
60EIF2AK10.68721856
61BMPR1B0.68562995
62PLK10.68163160
63CDK180.67691933
64CSNK2A20.67639071
65CDK150.67514875
66CDC70.67257986
67BTK0.64640700
68PRKCG0.64609677
69CDK140.62805638
70CASK0.62207113
71CDK11A0.61446427
72OBSCN0.61095475
73IKBKB0.60030637
74AURKB0.58966575
75MAPK130.58543799
76CAMK2A0.55362836
77GRK60.53217032
78ADRBK10.51826151
79PINK10.51178649
80CDK190.49353766
81PRKCI0.49244361
82RPS6KA40.49192638
83FES0.48151280
84CAMK10.47345828
85CSNK1A10.47237420
86TNK20.47183988
87PRKACA0.46683898
88PRKCQ0.46121113
89TAOK30.46077642
90CAMK2G0.45669850
91BRSK10.45634470
92ATR0.43282717
93MAP3K50.41920024
94ATM0.41562847
95IGF1R0.41530695
96NUAK10.40527625
97PBK0.39618033
98CAMK2D0.39510030
99STK390.39287150
100NTRK20.37901287

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.63759589
2Oxidative phosphorylation_Homo sapiens_hsa001905.13398577
3Parkinsons disease_Homo sapiens_hsa050124.40069460
4Proteasome_Homo sapiens_hsa030503.53982465
5Huntingtons disease_Homo sapiens_hsa050163.12986279
6RNA polymerase_Homo sapiens_hsa030203.01067813
7Alzheimers disease_Homo sapiens_hsa050103.00867080
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.65810701
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.62005457
10Protein export_Homo sapiens_hsa030602.57134559
11Cardiac muscle contraction_Homo sapiens_hsa042602.23625148
12Homologous recombination_Homo sapiens_hsa034402.23463416
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.10110737
14Spliceosome_Homo sapiens_hsa030402.08174784
15Pyrimidine metabolism_Homo sapiens_hsa002402.01869193
16DNA replication_Homo sapiens_hsa030301.92676789
17Primary immunodeficiency_Homo sapiens_hsa053401.88507336
18Mismatch repair_Homo sapiens_hsa034301.65565486
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.63866601
20Fanconi anemia pathway_Homo sapiens_hsa034601.59045059
21Selenocompound metabolism_Homo sapiens_hsa004501.57016860
22Nucleotide excision repair_Homo sapiens_hsa034201.50581132
23One carbon pool by folate_Homo sapiens_hsa006701.44729993
24Phototransduction_Homo sapiens_hsa047441.38435073
25Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.34091131
26Basal transcription factors_Homo sapiens_hsa030221.33992955
27Purine metabolism_Homo sapiens_hsa002301.26243890
28Steroid biosynthesis_Homo sapiens_hsa001001.19381115
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.07445488
30RNA transport_Homo sapiens_hsa030131.04028220
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.00172915
32RNA degradation_Homo sapiens_hsa030180.99589466
33Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.99190202
34Base excision repair_Homo sapiens_hsa034100.93746084
35Nitrogen metabolism_Homo sapiens_hsa009100.89516413
36Metabolic pathways_Homo sapiens_hsa011000.89441076
37Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.88970589
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.86271920
39Folate biosynthesis_Homo sapiens_hsa007900.85441190
40Peroxisome_Homo sapiens_hsa041460.82430174
41Collecting duct acid secretion_Homo sapiens_hsa049660.80366803
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.78042783
43Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.74023524
44Sulfur relay system_Homo sapiens_hsa041220.72865588
45Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.71449830
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.69085124
47Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.68765031
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.65689004
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62119475
50Cysteine and methionine metabolism_Homo sapiens_hsa002700.61446869
51Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.60510707
52Drug metabolism - other enzymes_Homo sapiens_hsa009830.56396144
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56230381
542-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.56085687
55Propanoate metabolism_Homo sapiens_hsa006400.53551409
56T cell receptor signaling pathway_Homo sapiens_hsa046600.52707153
57Retinol metabolism_Homo sapiens_hsa008300.51907148
58Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.51342900
59Linoleic acid metabolism_Homo sapiens_hsa005910.49437780
60Pyruvate metabolism_Homo sapiens_hsa006200.45912717
61Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45003409
62alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.43154739
63Primary bile acid biosynthesis_Homo sapiens_hsa001200.40617876
64Olfactory transduction_Homo sapiens_hsa047400.39607392
65Non-homologous end-joining_Homo sapiens_hsa034500.38741281
66Antigen processing and presentation_Homo sapiens_hsa046120.37260924
67mRNA surveillance pathway_Homo sapiens_hsa030150.36560746
68Chemical carcinogenesis_Homo sapiens_hsa052040.35190028
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.33971484
70Glutathione metabolism_Homo sapiens_hsa004800.32786096
71Butanoate metabolism_Homo sapiens_hsa006500.31772837
72Fat digestion and absorption_Homo sapiens_hsa049750.31122424
73Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.27871150
74Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.26613437
75Tyrosine metabolism_Homo sapiens_hsa003500.25324356
76SNARE interactions in vesicular transport_Homo sapiens_hsa041300.23587001
77N-Glycan biosynthesis_Homo sapiens_hsa005100.23578187
78Tryptophan metabolism_Homo sapiens_hsa003800.23302539
79Biosynthesis of amino acids_Homo sapiens_hsa012300.23237655
80Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.23068265
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.20363743
82Arachidonic acid metabolism_Homo sapiens_hsa005900.19735598
83Renin-angiotensin system_Homo sapiens_hsa046140.18148263
84Sulfur metabolism_Homo sapiens_hsa009200.17207122
85Nicotine addiction_Homo sapiens_hsa050330.16586571
86Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.15688642
87Ether lipid metabolism_Homo sapiens_hsa005650.15521246
88beta-Alanine metabolism_Homo sapiens_hsa004100.15460784
89Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.15056626
90Arginine and proline metabolism_Homo sapiens_hsa003300.14465850
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.14028073
92Fatty acid elongation_Homo sapiens_hsa000620.13652789
93Systemic lupus erythematosus_Homo sapiens_hsa053220.12553547
94Synaptic vesicle cycle_Homo sapiens_hsa047210.11941753
95Phenylalanine metabolism_Homo sapiens_hsa003600.11816133
96Cell cycle_Homo sapiens_hsa041100.11702056
97Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.11266681
98Mineral absorption_Homo sapiens_hsa049780.10836768
99Carbon metabolism_Homo sapiens_hsa012000.10638653
100Morphine addiction_Homo sapiens_hsa050320.10277171

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