PDCD5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is upregulated during apoptosis where it translocates rapidly from the cytoplasm to the nucleus. The encoded protein may be an important regulator of K(lysine) acetyltransferase 5 (a protein involved in transcription, DNA damage response and cell cycle control) by inhibiting its proteasome-dependent degradation. Pseudogenes have been identified on chromosomes 5 and 12 NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.67328656
2ATP synthesis coupled proton transport (GO:0015986)7.30904254
3energy coupled proton transport, down electrochemical gradient (GO:0015985)7.30904254
4ribosomal small subunit biogenesis (GO:0042274)6.26549430
5mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.14593120
6viral transcription (GO:0019083)6.04595555
7translational termination (GO:0006415)5.84633961
8ribosomal small subunit assembly (GO:0000028)5.64854570
9respiratory electron transport chain (GO:0022904)5.59523066
10electron transport chain (GO:0022900)5.46547877
11SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.36934568
12cotranslational protein targeting to membrane (GO:0006613)5.36048389
13protein targeting to ER (GO:0045047)5.29262628
14protein localization to endoplasmic reticulum (GO:0070972)5.04703190
15establishment of protein localization to endoplasmic reticulum (GO:0072599)5.03931674
16translational elongation (GO:0006414)5.00557624
17maturation of SSU-rRNA (GO:0030490)4.94824981
18GTP biosynthetic process (GO:0006183)4.86940020
19proteasome assembly (GO:0043248)4.80533971
20viral life cycle (GO:0019058)4.69346299
21cellular protein complex disassembly (GO:0043624)4.68693710
22establishment of protein localization to mitochondrial membrane (GO:0090151)4.65689054
23chaperone-mediated protein transport (GO:0072321)4.58874943
24ribosomal large subunit biogenesis (GO:0042273)4.58703257
25protein neddylation (GO:0045116)4.54044173
26translational initiation (GO:0006413)4.41854875
27mitochondrial respiratory chain complex I assembly (GO:0032981)4.41270124
28NADH dehydrogenase complex assembly (GO:0010257)4.41270124
29mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.41270124
30nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.40689507
31chromatin remodeling at centromere (GO:0031055)4.39777728
32protein complex biogenesis (GO:0070271)4.34855074
33CENP-A containing nucleosome assembly (GO:0034080)4.34709174
34translation (GO:0006412)4.32202976
35DNA deamination (GO:0045006)4.32148736
36UTP biosynthetic process (GO:0006228)4.28980565
37establishment of integrated proviral latency (GO:0075713)4.11669914
38mitochondrial respiratory chain complex assembly (GO:0033108)4.06000808
39regulation of mitochondrial translation (GO:0070129)4.03518323
40transcription elongation from RNA polymerase III promoter (GO:0006385)4.00631960
41termination of RNA polymerase III transcription (GO:0006386)4.00631960
42protein complex disassembly (GO:0043241)3.98867239
43guanosine-containing compound biosynthetic process (GO:1901070)3.97877598
44purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.94233100
45negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.93122459
46cullin deneddylation (GO:0010388)3.91898654
47purine nucleoside triphosphate biosynthetic process (GO:0009145)3.86641343
48macromolecular complex disassembly (GO:0032984)3.82362440
497-methylguanosine mRNA capping (GO:0006370)3.76559643
50DNA replication checkpoint (GO:0000076)3.74391179
517-methylguanosine RNA capping (GO:0009452)3.73885831
52RNA capping (GO:0036260)3.73885831
53regulation of cellular amino acid metabolic process (GO:0006521)3.73178417
54ribonucleoprotein complex biogenesis (GO:0022613)3.68491113
55ATP biosynthetic process (GO:0006754)3.67745408
56oxidative phosphorylation (GO:0006119)3.67420181
57negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.66288518
58negative regulation of ligase activity (GO:0051352)3.66288518
59pseudouridine synthesis (GO:0001522)3.66091245
60DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.61424085
61UTP metabolic process (GO:0046051)3.60801663
62protein targeting to mitochondrion (GO:0006626)3.60379577
63establishment of protein localization to mitochondrion (GO:0072655)3.60345569
64positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.58781359
65protein deneddylation (GO:0000338)3.56923956
66CTP biosynthetic process (GO:0006241)3.56075122
67CTP metabolic process (GO:0046036)3.56075122
68cellular component biogenesis (GO:0044085)3.54920805
69intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.54297773
70signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.54297773
71ribonucleoside triphosphate biosynthetic process (GO:0009201)3.54110540
72nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.53250744
73signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.50903129
74signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.50903129
75signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.50903129
76respiratory chain complex IV assembly (GO:0008535)3.49933230
77spliceosomal snRNP assembly (GO:0000387)3.49610297
78DNA damage response, detection of DNA damage (GO:0042769)3.49052712
79histone exchange (GO:0043486)3.48268722
80establishment of viral latency (GO:0019043)3.48168734
81regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.48075745
82exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.47552782
83rRNA modification (GO:0000154)3.46040155
84protein targeting to membrane (GO:0006612)3.45688016
85tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.43258174
86RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.43258174
87antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.41145194
88hydrogen ion transmembrane transport (GO:1902600)3.40534251
89signal transduction involved in DNA integrity checkpoint (GO:0072401)3.40326923
90signal transduction involved in DNA damage checkpoint (GO:0072422)3.40326923
91pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.39024248
92inner mitochondrial membrane organization (GO:0007007)3.38553172
93signal transduction involved in cell cycle checkpoint (GO:0072395)3.37130755
94deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.36826421
95DNA replication-independent nucleosome organization (GO:0034724)3.36373804
96DNA replication-independent nucleosome assembly (GO:0006336)3.36373804
97anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.34299072
98kinetochore organization (GO:0051383)3.32476304
99nuclear-transcribed mRNA catabolic process (GO:0000956)3.31413484
100purine nucleobase biosynthetic process (GO:0009113)3.30934745
101DNA strand elongation involved in DNA replication (GO:0006271)3.30744703
102telomere maintenance via semi-conservative replication (GO:0032201)3.29737514
103formation of translation preinitiation complex (GO:0001731)3.29320520
104spliceosomal complex assembly (GO:0000245)3.28987101
105rRNA processing (GO:0006364)3.26969387
106protein localization to mitochondrion (GO:0070585)3.26471988
107positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.25959899
108mitotic metaphase plate congression (GO:0007080)3.22645129
109pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.22295848
110pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.19730829
111DNA strand elongation (GO:0022616)3.18370495
112kinetochore assembly (GO:0051382)3.14987807
113nucleoside triphosphate biosynthetic process (GO:0009142)3.14983386
114antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.13988235
115rRNA metabolic process (GO:0016072)3.13951423
116mRNA catabolic process (GO:0006402)3.12885419
117cytochrome complex assembly (GO:0017004)3.12009224
118peptidyl-histidine modification (GO:0018202)3.11399059
119mitochondrial transport (GO:0006839)3.10622217
120positive regulation of ligase activity (GO:0051351)3.10453664
121transcription-coupled nucleotide-excision repair (GO:0006283)3.08566286
122histone mRNA metabolic process (GO:0008334)3.07518957

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.91626170
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.76129348
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.52965328
4EST1_17652178_ChIP-ChIP_JURKAT_Human4.28663979
5MYC_18555785_ChIP-Seq_MESCs_Mouse4.24190023
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.86927031
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.62193353
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.60527219
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.38918262
10CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.38128368
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.34258849
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.31448884
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.26475668
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.02135837
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.93840358
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.76280067
17E2F7_22180533_ChIP-Seq_HELA_Human2.69611289
18* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.67178704
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.60766855
20VDR_23849224_ChIP-Seq_CD4+_Human2.57666941
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.50744422
22DCP1A_22483619_ChIP-Seq_HELA_Human2.43556592
23ELK1_19687146_ChIP-ChIP_HELA_Human2.37196289
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.34488493
25SRF_21415370_ChIP-Seq_HL-1_Mouse2.31327404
26FOXM1_23109430_ChIP-Seq_U2OS_Human2.30240465
27XRN2_22483619_ChIP-Seq_HELA_Human2.29478800
28E2F4_17652178_ChIP-ChIP_JURKAT_Human2.23600209
29THAP11_20581084_ChIP-Seq_MESCs_Mouse2.23045427
30TTF2_22483619_ChIP-Seq_HELA_Human2.20013559
31* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.11544023
32NELFA_20434984_ChIP-Seq_ESCs_Mouse2.02248409
33YY1_21170310_ChIP-Seq_MESCs_Mouse2.01951818
34* FOXP3_21729870_ChIP-Seq_TREG_Human1.97136780
35PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.95101210
36ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.94986988
37MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.93183837
38* GABP_19822575_ChIP-Seq_HepG2_Human1.83329172
39CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.82524283
40FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.81495588
41AR_21909140_ChIP-Seq_LNCAP_Human1.80667565
42FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.80411152
43MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.68906178
44ELK1_22589737_ChIP-Seq_MCF10A_Human1.66852456
45RBPJ_22232070_ChIP-Seq_NCS_Mouse1.59524773
46* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.58600851
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.54719571
48YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.49892463
49MYC_18940864_ChIP-ChIP_HL60_Human1.49564180
50POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.48437240
51TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.44602881
52PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43909990
53VDR_22108803_ChIP-Seq_LS180_Human1.37677943
54MYCN_18555785_ChIP-Seq_MESCs_Mouse1.36510592
55SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.36465355
56TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.35065676
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.29432618
58IRF1_19129219_ChIP-ChIP_H3396_Human1.28328656
59* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.26936631
60KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.23930431
61FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.19305967
62ERG_20887958_ChIP-Seq_HPC-7_Mouse1.19222613
63HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.17936305
64* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.14378591
65TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13660584
66FUS_26573619_Chip-Seq_HEK293_Human1.13031671
67KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.13016129
68PADI4_21655091_ChIP-ChIP_MCF-7_Human1.11461902
69CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.09124445
70CTCF_18555785_ChIP-Seq_MESCs_Mouse1.01249589
71BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.99781326
72FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.98846429
73BMI1_23680149_ChIP-Seq_NPCS_Mouse0.98575857
74NANOG_16153702_ChIP-ChIP_HESCs_Human0.97404555
75CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.96305519
76SOX17_20123909_ChIP-Seq_XEN_Mouse0.93842073
77NANOG_18555785_ChIP-Seq_MESCs_Mouse0.93497882
78POU5F1_16153702_ChIP-ChIP_HESCs_Human0.92297963
79SOX2_18555785_ChIP-Seq_MESCs_Mouse0.90758381
80CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.89410133
81TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.86558648
82CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.85294621
83CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.83236217
84E2F1_21310950_ChIP-Seq_MCF-7_Human0.83058022
85* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.80490859
86ZNF274_21170338_ChIP-Seq_K562_Hela0.79394530
87CBX2_27304074_Chip-Seq_ESCs_Mouse0.79021390
88CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.78301019
89PCGF2_27294783_Chip-Seq_ESCs_Mouse0.77956681
90PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.77645107
91NOTCH1_21737748_ChIP-Seq_TLL_Human0.77633374
92FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.77278215
93SOX2_16153702_ChIP-ChIP_HESCs_Human0.76892864
94RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.76850850
95CIITA_25753668_ChIP-Seq_RAJI_Human0.76417362
96* EWS_26573619_Chip-Seq_HEK293_Human0.75063167
97POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.74464336
98TP63_19390658_ChIP-ChIP_HaCaT_Human0.73028803
99DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.72788154
100ZNF263_19887448_ChIP-Seq_K562_Human0.72786681
101* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.72694810
102PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.72568783
103HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.72091263
104SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.71947818
105BP1_19119308_ChIP-ChIP_Hs578T_Human0.71651627
106CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.71446064
107IGF1R_20145208_ChIP-Seq_DFB_Human0.70233542
108KDM5A_27292631_Chip-Seq_BREAST_Human0.69333397
109ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.69231053
110FOXP1_21924763_ChIP-Seq_HESCs_Human0.69190641
111ZFP57_27257070_Chip-Seq_ESCs_Mouse0.68860686
112SOX2_18692474_ChIP-Seq_MEFs_Mouse0.68810091
113E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.68113813
114CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.68102680
115SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.67446470
116FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.66846528
117STAT1_20625510_ChIP-Seq_HELA_Human0.66708889

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.95288180
2MP0001529_abnormal_vocalization3.38696500
3MP0003693_abnormal_embryo_hatching2.69883974
4MP0004957_abnormal_blastocyst_morpholog2.63225298
5MP0003880_abnormal_central_pattern2.51820918
6MP0008877_abnormal_DNA_methylation2.41521798
7MP0008932_abnormal_embryonic_tissue2.34595084
8MP0003136_yellow_coat_color2.34507371
9MP0001905_abnormal_dopamine_level2.24605248
10MP0008057_abnormal_DNA_replication2.22236061
11MP0008058_abnormal_DNA_repair2.21556590
12MP0010094_abnormal_chromosome_stability2.19921155
13MP0003806_abnormal_nucleotide_metabolis2.17125919
14MP0002938_white_spotting2.13695678
15MP0006292_abnormal_olfactory_placode2.07950413
16MP0002102_abnormal_ear_morphology2.05930478
17MP0006276_abnormal_autonomic_nervous2.04151289
18MP0001188_hyperpigmentation1.99629046
19MP0005410_abnormal_fertilization1.97031001
20MP0003077_abnormal_cell_cycle1.91934595
21MP0000566_synostosis1.85586210
22MP0001293_anophthalmia1.84303593
23MP0006036_abnormal_mitochondrial_physio1.81013032
24MP0002234_abnormal_pharynx_morphology1.75807298
25MP0002638_abnormal_pupillary_reflex1.75120692
26MP0000372_irregular_coat_pigmentation1.72164622
27MP0003786_premature_aging1.62307084
28MP0006035_abnormal_mitochondrial_morpho1.61527308
29MP0003315_abnormal_perineum_morphology1.60451025
30MP0005409_darkened_coat_color1.57176682
31MP0003122_maternal_imprinting1.56936732
32MP0003186_abnormal_redox_activity1.52740844
33MP0005171_absent_coat_pigmentation1.48541385
34MP0000749_muscle_degeneration1.48144719
35MP0003718_maternal_effect1.47330538
36MP0003111_abnormal_nucleus_morphology1.45732607
37MP0003121_genomic_imprinting1.43728181
38MP0004142_abnormal_muscle_tone1.43009942
39MP0006072_abnormal_retinal_apoptosis1.40759146
40MP0001727_abnormal_embryo_implantation1.38188352
41MP0001986_abnormal_taste_sensitivity1.36415430
42MP0000350_abnormal_cell_proliferation1.34538278
43MP0003123_paternal_imprinting1.33317386
44MP0003937_abnormal_limbs/digits/tail_de1.32443630
45MP0010030_abnormal_orbit_morphology1.32370800
46MP0000049_abnormal_middle_ear1.32293211
47MP0002736_abnormal_nociception_after1.32232984
48MP0002163_abnormal_gland_morphology1.31026290
49MP0008789_abnormal_olfactory_epithelium1.30157377
50MP0002751_abnormal_autonomic_nervous1.29050159
51MP0002233_abnormal_nose_morphology1.25199980
52MP0005423_abnormal_somatic_nervous1.24319011
53MP0008007_abnormal_cellular_replicative1.23083959
54MP0002210_abnormal_sex_determination1.23045783
55MP0004145_abnormal_muscle_electrophysio1.22711728
56MP0005084_abnormal_gallbladder_morpholo1.21629050
57MP0001929_abnormal_gametogenesis1.19668933
58MP0004133_heterotaxia1.19539914
59MP0003941_abnormal_skin_development1.13680754
60MP0003698_abnormal_male_reproductive1.12241835
61MP0001485_abnormal_pinna_reflex1.11344776
62MP0001697_abnormal_embryo_size1.10457935
63MP0001764_abnormal_homeostasis1.09600649
64MP0002160_abnormal_reproductive_system1.05994927
65MP0003011_delayed_dark_adaptation1.05598296
66MP0005389_reproductive_system_phenotype1.05163473
67MP0001968_abnormal_touch/_nociception1.04977054
68MP0004215_abnormal_myocardial_fiber1.04543943
69MP0008995_early_reproductive_senescence1.04257967
70MP0002132_abnormal_respiratory_system1.04142609
71MP0003646_muscle_fatigue1.02282544
72MP0003890_abnormal_embryonic-extraembry1.02024203
73MP0001286_abnormal_eye_development1.01865638
74MP0005187_abnormal_penis_morphology1.01804507
75MP0002697_abnormal_eye_size1.00051437
76MP0009697_abnormal_copulation0.99765056
77MP0003567_abnormal_fetal_cardiomyocyte0.99583894
78MP0002735_abnormal_chemical_nociception0.98289468
79MP0002085_abnormal_embryonic_tissue0.97744647
80MP0001145_abnormal_male_reproductive0.96676901
81MP0001672_abnormal_embryogenesis/_devel0.96484757
82MP0005380_embryogenesis_phenotype0.96484757
83MP0000026_abnormal_inner_ear0.95793705
84MP0000015_abnormal_ear_pigmentation0.94592798
85MP0005408_hypopigmentation0.88928588
86MP0000647_abnormal_sebaceous_gland0.87721374
87MP0003950_abnormal_plasma_membrane0.87415483
88MP0009053_abnormal_anal_canal0.87292498
89MP0003119_abnormal_digestive_system0.87266333
90MP0005174_abnormal_tail_pigmentation0.87012114
91MP0003938_abnormal_ear_development0.86148402
92MP0002080_prenatal_lethality0.85288128
93MP0002837_dystrophic_cardiac_calcinosis0.83505816
94MP0002084_abnormal_developmental_patter0.83031538
95MP0000653_abnormal_sex_gland0.81930525
96MP0001984_abnormal_olfaction0.81889818
97MP0004742_abnormal_vestibular_system0.81873345
98MP0000762_abnormal_tongue_morphology0.81656203
99MP0002111_abnormal_tail_morphology0.80999849
100MP0009250_abnormal_appendicular_skeleto0.80204585
101MP0003385_abnormal_body_wall0.79876220
102MP0005499_abnormal_olfactory_system0.78639505
103MP0005394_taste/olfaction_phenotype0.78639505
104MP0004381_abnormal_hair_follicle0.78409227
105MP0003755_abnormal_palate_morphology0.78322390
106MP0005253_abnormal_eye_physiology0.77919504
107MP0004147_increased_porphyrin_level0.77190642
108MP0002277_abnormal_respiratory_mucosa0.76641814
109MP0003137_abnormal_impulse_conducting0.76003785
110MP0010386_abnormal_urinary_bladder0.75414515
111MP0004134_abnormal_chest_morphology0.75183971
112MP0005379_endocrine/exocrine_gland_phen0.75110054
113MP0000750_abnormal_muscle_regeneration0.74471247
114MP0002095_abnormal_skin_pigmentation0.73882952
115MP0005075_abnormal_melanosome_morpholog0.73840951
116MP0005391_vision/eye_phenotype0.72902659
117MP0005330_cardiomyopathy0.70708326
118MP0001119_abnormal_female_reproductive0.70704283
119MP0003984_embryonic_growth_retardation0.70648894
120MP0001919_abnormal_reproductive_system0.70097444
121MP0000631_abnormal_neuroendocrine_gland0.70090651
122MP0002752_abnormal_somatic_nervous0.69977490
123MP0000313_abnormal_cell_death0.69859843
124MP0004036_abnormal_muscle_relaxation0.69858907
125MP0003942_abnormal_urinary_system0.67649601
126MP0000358_abnormal_cell_content/0.67580147
127MP0002177_abnormal_outer_ear0.67410152
128MP0002127_abnormal_cardiovascular_syste0.66943304
129MP0002090_abnormal_vision0.66908117
130MP0002088_abnormal_embryonic_growth/wei0.66892579
131MP0002282_abnormal_trachea_morphology0.66176212
132MP0001963_abnormal_hearing_physiology0.65630044
133MP0001730_embryonic_growth_arrest0.65417407
134MP0003221_abnormal_cardiomyocyte_apopto0.64961222
135MP0002106_abnormal_muscle_physiology0.64722077

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.76111384
2Abnormal mitochondria in muscle tissue (HP:0008316)6.07075260
3Mitochondrial inheritance (HP:0001427)5.94034124
4Progressive macrocephaly (HP:0004481)5.57809783
5Acute encephalopathy (HP:0006846)5.27689943
6Abnormality of cells of the erythroid lineage (HP:0012130)5.10275378
7Increased hepatocellular lipid droplets (HP:0006565)5.07951624
8Increased CSF lactate (HP:0002490)5.07790611
9Hepatocellular necrosis (HP:0001404)4.96096798
10Abnormal number of erythroid precursors (HP:0012131)4.59908922
11Lipid accumulation in hepatocytes (HP:0006561)4.47734759
12Reticulocytopenia (HP:0001896)4.42667122
13Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.41090015
14Decreased activity of mitochondrial respiratory chain (HP:0008972)4.34694158
15Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.34694158
16Hepatic necrosis (HP:0002605)4.24219316
17Renal Fanconi syndrome (HP:0001994)4.19966511
18Muscle abnormality related to mitochondrial dysfunction (HP:0003800)4.18784245
193-Methylglutaconic aciduria (HP:0003535)4.07367404
20Exercise intolerance (HP:0003546)3.83969429
21Abnormality of glycolysis (HP:0004366)3.57564737
22Increased serum pyruvate (HP:0003542)3.57564737
23Increased intramyocellular lipid droplets (HP:0012240)3.54015951
24Increased serum lactate (HP:0002151)3.53884888
25Exertional dyspnea (HP:0002875)3.53510547
26Optic disc pallor (HP:0000543)3.52760699
27Respiratory failure (HP:0002878)3.46309782
28Macrocytic anemia (HP:0001972)3.43707276
29Cerebral edema (HP:0002181)3.34323668
30Leukodystrophy (HP:0002415)3.33791218
31Lactic acidosis (HP:0003128)3.28275967
32Pallor (HP:0000980)3.22670638
33Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.15109676
34Increased muscle lipid content (HP:0009058)2.88391092
35Abnormality of renal resorption (HP:0011038)2.81217646
36Respiratory difficulties (HP:0002880)2.78012588
37Degeneration of anterior horn cells (HP:0002398)2.60233654
38Abnormality of the anterior horn cell (HP:0006802)2.60233654
39Microvesicular hepatic steatosis (HP:0001414)2.53193598
40Parakeratosis (HP:0001036)2.42569918
41Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.40061461
42Abnormality of alanine metabolism (HP:0010916)2.40061461
43Hyperalaninemia (HP:0003348)2.40061461
44Meckel diverticulum (HP:0002245)2.34263545
45Colon cancer (HP:0003003)2.26815234
46Type I transferrin isoform profile (HP:0003642)2.24054064
47Cerebral hypomyelination (HP:0006808)2.23855949
48Lethargy (HP:0001254)2.22093393
49Abnormality of the ileum (HP:0001549)2.20405473
50Abnormality of secondary sexual hair (HP:0009888)2.19200386
51Abnormality of the axillary hair (HP:0100134)2.19200386
52Aplasia/Hypoplasia of the sacrum (HP:0008517)2.16377392
53Abnormality of the preputium (HP:0100587)2.14591662
54Aplasia/Hypoplasia of the uvula (HP:0010293)2.13586979
55Medial flaring of the eyebrow (HP:0010747)2.12353039
56Abnormal respiratory motile cilium morphology (HP:0005938)2.12342326
57Abnormal respiratory epithelium morphology (HP:0012253)2.12342326
58Methylmalonic acidemia (HP:0002912)2.11255165
59Hypothermia (HP:0002045)2.10225377
60Dynein arm defect of respiratory motile cilia (HP:0012255)2.10129505
61Absent/shortened dynein arms (HP:0200106)2.10129505
62Emotional lability (HP:0000712)2.09096955
63Hyperglycinemia (HP:0002154)2.08889092
64Abnormality of methionine metabolism (HP:0010901)2.06950943
65Chromsome breakage (HP:0040012)2.06747686
66Chromosomal breakage induced by crosslinking agents (HP:0003221)2.04868081
67Birth length less than 3rd percentile (HP:0003561)2.02883862
68Pancytopenia (HP:0001876)2.02838584
69CNS demyelination (HP:0007305)2.01488376
70Testicular atrophy (HP:0000029)2.01362107
71Aplastic anemia (HP:0001915)1.98989526
7211 pairs of ribs (HP:0000878)1.97693350
73Abnormality of chromosome stability (HP:0003220)1.96683032
74Congenital ichthyosiform erythroderma (HP:0007431)1.94870960
75Multiple enchondromatosis (HP:0005701)1.93007133
76Sparse eyelashes (HP:0000653)1.92288873
77X-linked dominant inheritance (HP:0001423)1.91147372
78Abnormality of serum amino acid levels (HP:0003112)1.89993827
79Abnormality of midbrain morphology (HP:0002418)1.88252036
80Molar tooth sign on MRI (HP:0002419)1.88252036
81Methylmalonic aciduria (HP:0012120)1.87050536
82Hyperphosphaturia (HP:0003109)1.86720011
83Reduced antithrombin III activity (HP:0001976)1.86499125
84Abnormality of urine glucose concentration (HP:0011016)1.84968556
85Glycosuria (HP:0003076)1.84968556
86Megaloblastic anemia (HP:0001889)1.83195924
87Triphalangeal thumb (HP:0001199)1.83040138
88Abnormal protein N-linked glycosylation (HP:0012347)1.81979073
89Abnormal protein glycosylation (HP:0012346)1.81979073
90Abnormal glycosylation (HP:0012345)1.81979073
91Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.81979073
92Generalized aminoaciduria (HP:0002909)1.81946039
93Microretrognathia (HP:0000308)1.81866942
94Oral leukoplakia (HP:0002745)1.81416438
95Abnormality of placental membranes (HP:0011409)1.79097514
96Amniotic constriction ring (HP:0009775)1.79097514
97Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.78897183
98Abnormality of the heme biosynthetic pathway (HP:0010472)1.78129848
99Abnormality of the labia minora (HP:0012880)1.76704962
100Absent thumb (HP:0009777)1.73973842
101Abnormal ciliary motility (HP:0012262)1.72843745
102Breast hypoplasia (HP:0003187)1.72556620
103Abnormal pupillary function (HP:0007686)1.72103880
104Duplicated collecting system (HP:0000081)1.68576916
105Renal tubular dysfunction (HP:0000124)1.66105056
106Septo-optic dysplasia (HP:0100842)1.65951964
107Blindness (HP:0000618)1.65078440
108Small intestinal stenosis (HP:0012848)1.63703484
109Duodenal stenosis (HP:0100867)1.63703484
110Congenital, generalized hypertrichosis (HP:0004540)1.63505001
111Supernumerary spleens (HP:0009799)1.62971893
112Aplasia/Hypoplasia of the tibia (HP:0005772)1.62869025
113Pancreatic fibrosis (HP:0100732)1.62606876
114Hypoplastic pelvis (HP:0008839)1.62000555
115Hypoplastic left heart (HP:0004383)1.59668883
116Congenital primary aphakia (HP:0007707)1.59223683
117Retinal dysplasia (HP:0007973)1.58485757
118Aplasia/hypoplasia of the uterus (HP:0008684)1.58133739
119Severe visual impairment (HP:0001141)1.57495038
120Sclerocornea (HP:0000647)1.56233616
121Abnormality of the renal collecting system (HP:0004742)1.56008232
122Progressive external ophthalmoplegia (HP:0000590)1.55790818
123Abnormal number of incisors (HP:0011064)1.55518185
124Hypoplasia of the radius (HP:0002984)1.55014723
125Abnormal respiratory motile cilium physiology (HP:0012261)1.53894296
126Duplication of thumb phalanx (HP:0009942)1.53816948
127Gait imbalance (HP:0002141)1.53317951
128Nephrogenic diabetes insipidus (HP:0009806)1.53127793
129Rough bone trabeculation (HP:0100670)1.52489116
130Short tibia (HP:0005736)1.52057960
131Abnormal urine phosphate concentration (HP:0012599)1.52001440
132Stenosis of the external auditory canal (HP:0000402)1.51974526
133Cleft eyelid (HP:0000625)1.51658185
134Absent radius (HP:0003974)1.51511646
135Abnormal lung lobation (HP:0002101)1.51250296
136Facial cleft (HP:0002006)1.51150839
137True hermaphroditism (HP:0010459)1.49794319
138Horseshoe kidney (HP:0000085)1.48871258
139Hypoplastic heart (HP:0001961)1.47976186

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK164.30026123
2VRK24.01346084
3BUB13.89927542
4NME23.62163643
5NEK13.45202066
6NME13.26291795
7PBK2.67070392
8EIF2AK12.60708841
9WEE12.53400051
10VRK12.53358043
11SRPK12.30932042
12EIF2AK32.27093022
13TLK11.99816736
14MYLK1.90367649
15MAP3K121.85050171
16PIM21.84161912
17TRIM281.70692081
18LIMK11.67519807
19TNIK1.65099349
20OBSCN1.62173313
21PLK41.61594863
22CASK1.55202402
23STK391.51037177
24CDC71.49501376
25BMPR1B1.49443502
26ARAF1.48675395
27MUSK1.44613629
28BCKDK1.43413950
29MKNK11.41895247
30MST41.40919549
31DYRK21.39677088
32ZAK1.37507769
33GRK71.36986447
34BCR1.33273843
35TESK11.29018623
36PNCK1.28938368
37BRAF1.22230088
38MAP4K21.20153056
39ACVR1B1.15024721
40ILK1.13249491
41TESK21.11131913
42CDK81.05669325
43BRSK21.02544068
44DYRK31.01849410
45AURKA1.00046297
46KDR1.00030957
47EIF2AK21.00018896
48CDK190.97962209
49TAF10.95460028
50ADRBK20.92965877
51RPS6KA50.91599485
52MKNK20.89964998
53PLK10.88189431
54NEK20.87019782
55CSNK1G20.82382454
56CSNK1G30.82119765
57ERBB30.81736381
58PLK30.79981955
59AURKB0.79755461
60IRAK30.77255964
61ABL20.77029659
62* CSNK2A10.74157476
63STK38L0.73836948
64STK240.73341025
65MAPKAPK50.72935574
66CHEK10.72790681
67MAPK130.71999637
68RPS6KB20.71737181
69CSNK1A1L0.71465958
70RPS6KA40.70898152
71TSSK60.70828198
72OXSR10.68614652
73IRAK40.68349619
74PAK40.68045270
75YES10.67245552
76PAK10.66803429
77UHMK10.64315787
78CHEK20.63991054
79WNK40.63946815
80* CSNK2A20.62685949
81ATM0.62432966
82STK40.61108458
83DAPK10.60015679
84MAP3K110.59263465
85DAPK30.55718002
86CSNK1E0.53637076
87MINK10.53039227
88CDK70.52245177
89CCNB10.52037354
90GRK50.51791528
91BMPR20.50275574
92MAP3K40.49970340
93ADRBK10.49912962
94SCYL20.49081597
95LRRK20.48393464
96MAP2K70.48218689
97MARK10.48205242
98ROCK20.47831476
99CDK30.45884159
100ATR0.45759954
101CAMK2B0.44453213
102PDK40.44217388
103PDK30.44217388
104IRAK10.43933499
105PRKCI0.42704428
106CAMK2D0.42360166
107ERBB40.42338521
108PLK20.42150040
109TTK0.40972262
110CDK10.40025040
111PASK0.39039499
112IRAK20.38677258
113CDK140.38563626
114PRKCG0.37995729
115INSRR0.37627458
116BRSK10.37597386
117GRK10.36437136
118MAP3K80.35998112
119CDK20.35478393
120NUAK10.35452464
121NEK60.34934956
122CSNK1G10.34816436
123EPHA40.34277328
124TEC0.33901053
125ALK0.33809646
126CDK180.33315129
127CDK11A0.32508584
128WNK30.31926780
129PDK20.29427190
130SIK30.29290472

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.36300811
2Oxidative phosphorylation_Homo sapiens_hsa001905.09284974
3Parkinsons disease_Homo sapiens_hsa050124.49867662
4Proteasome_Homo sapiens_hsa030504.40748075
5RNA polymerase_Homo sapiens_hsa030203.48261229
6Huntingtons disease_Homo sapiens_hsa050163.47757110
7Alzheimers disease_Homo sapiens_hsa050103.23148741
8Protein export_Homo sapiens_hsa030602.92212003
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.70980856
10DNA replication_Homo sapiens_hsa030302.70001353
11Spliceosome_Homo sapiens_hsa030402.39586590
12Mismatch repair_Homo sapiens_hsa034302.34107225
13Pyrimidine metabolism_Homo sapiens_hsa002402.29896777
14Cardiac muscle contraction_Homo sapiens_hsa042602.27184638
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.14022541
16Homologous recombination_Homo sapiens_hsa034402.09990922
17Nucleotide excision repair_Homo sapiens_hsa034201.96404851
18Basal transcription factors_Homo sapiens_hsa030221.91186171
19RNA transport_Homo sapiens_hsa030131.55116979
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.53230181
21Base excision repair_Homo sapiens_hsa034101.48952316
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.44287611
23RNA degradation_Homo sapiens_hsa030181.41954972
24Fanconi anemia pathway_Homo sapiens_hsa034601.38727199
25Purine metabolism_Homo sapiens_hsa002301.38097845
26Non-homologous end-joining_Homo sapiens_hsa034501.33883547
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.29877587
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.14064242
29Propanoate metabolism_Homo sapiens_hsa006401.12664520
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.03235849
31Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.99281708
32Cell cycle_Homo sapiens_hsa041100.98268765
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.91666272
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.89099037
35Vitamin B6 metabolism_Homo sapiens_hsa007500.85591330
36Collecting duct acid secretion_Homo sapiens_hsa049660.85335636
37Systemic lupus erythematosus_Homo sapiens_hsa053220.80326808
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.79415925
39Arachidonic acid metabolism_Homo sapiens_hsa005900.75469433
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.75389881
41Biosynthesis of amino acids_Homo sapiens_hsa012300.74573068
42SNARE interactions in vesicular transport_Homo sapiens_hsa041300.72916626
43Glutathione metabolism_Homo sapiens_hsa004800.72698068
44Fatty acid elongation_Homo sapiens_hsa000620.72667566
45Epstein-Barr virus infection_Homo sapiens_hsa051690.72140695
46Metabolic pathways_Homo sapiens_hsa011000.71804769
47Sulfur relay system_Homo sapiens_hsa041220.70072102
48One carbon pool by folate_Homo sapiens_hsa006700.67594039
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.67049885
50Vibrio cholerae infection_Homo sapiens_hsa051100.66645487
51Selenocompound metabolism_Homo sapiens_hsa004500.64975424
52mRNA surveillance pathway_Homo sapiens_hsa030150.60791328
53Linoleic acid metabolism_Homo sapiens_hsa005910.58965437
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54249023
55Ether lipid metabolism_Homo sapiens_hsa005650.53799904
56p53 signaling pathway_Homo sapiens_hsa041150.51458348
57Sulfur metabolism_Homo sapiens_hsa009200.50544792
58Folate biosynthesis_Homo sapiens_hsa007900.50266549
59Peroxisome_Homo sapiens_hsa041460.48679712
60Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47652162
61Butanoate metabolism_Homo sapiens_hsa006500.46807325
62Alcoholism_Homo sapiens_hsa050340.44732159
63Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.44031638
64Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.43928459
65Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.43067142
66Graft-versus-host disease_Homo sapiens_hsa053320.42935877
67Phototransduction_Homo sapiens_hsa047440.40659884
68Steroid biosynthesis_Homo sapiens_hsa001000.37488840
69Pyruvate metabolism_Homo sapiens_hsa006200.36131503
70Rheumatoid arthritis_Homo sapiens_hsa053230.35469890
71Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34435977
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.33047974
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.32188803
74Serotonergic synapse_Homo sapiens_hsa047260.30931008
75Sphingolipid metabolism_Homo sapiens_hsa006000.30390486
76Autoimmune thyroid disease_Homo sapiens_hsa053200.29471067
77Asthma_Homo sapiens_hsa053100.28922880
78Phagosome_Homo sapiens_hsa041450.28491420
79beta-Alanine metabolism_Homo sapiens_hsa004100.28473251
80N-Glycan biosynthesis_Homo sapiens_hsa005100.28318272
81Cysteine and methionine metabolism_Homo sapiens_hsa002700.28073609
82Allograft rejection_Homo sapiens_hsa053300.27786187
83Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.27438313
84Oocyte meiosis_Homo sapiens_hsa041140.25835664
85Fatty acid metabolism_Homo sapiens_hsa012120.25398073
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.24209565
87Tyrosine metabolism_Homo sapiens_hsa003500.23517050
88Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.22450051
89Tryptophan metabolism_Homo sapiens_hsa003800.22198443
90Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.21085054
91Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.20756532
92Fatty acid degradation_Homo sapiens_hsa000710.19882610
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.19877340
94Arginine and proline metabolism_Homo sapiens_hsa003300.18061769
95Pentose phosphate pathway_Homo sapiens_hsa000300.17938023
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.17370930
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.17143812
98Chemical carcinogenesis_Homo sapiens_hsa052040.14683513
99TGF-beta signaling pathway_Homo sapiens_hsa043500.14198802
100Herpes simplex infection_Homo sapiens_hsa051680.11095896
101Carbon metabolism_Homo sapiens_hsa012000.10397160
102Galactose metabolism_Homo sapiens_hsa000520.10079556
103Viral carcinogenesis_Homo sapiens_hsa052030.09893461
104Maturity onset diabetes of the young_Homo sapiens_hsa049500.09272241
105Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.09087482
106Phenylalanine metabolism_Homo sapiens_hsa003600.09053562
107Regulation of autophagy_Homo sapiens_hsa041400.08855397
108Fructose and mannose metabolism_Homo sapiens_hsa000510.08352606
109Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.06908602
110Hippo signaling pathway_Homo sapiens_hsa043900.06843797
111Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.06089020
112Vitamin digestion and absorption_Homo sapiens_hsa049770.05929433
113Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.05359477
114Retinol metabolism_Homo sapiens_hsa008300.04985164
115Fat digestion and absorption_Homo sapiens_hsa049750.04582000
116Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.04573671
117Hematopoietic cell lineage_Homo sapiens_hsa046400.04553896
118Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.04267411
119Drug metabolism - other enzymes_Homo sapiens_hsa009830.03092261
120Basal cell carcinoma_Homo sapiens_hsa052170.03037253
121Hedgehog signaling pathway_Homo sapiens_hsa043400.02119053
122Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.01836751
123Taste transduction_Homo sapiens_hsa047420.01722827
124Nicotine addiction_Homo sapiens_hsa050330.00557775
125Antigen processing and presentation_Homo sapiens_hsa04612-0.0454729
126Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514-0.0362526
127Type I diabetes mellitus_Homo sapiens_hsa04940-0.0303363
128Malaria_Homo sapiens_hsa05144-0.0251177
129Tight junction_Homo sapiens_hsa04530-0.0237006
130Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060-0.0208659
131Legionellosis_Homo sapiens_hsa05134-0.0168316
132HTLV-I infection_Homo sapiens_hsa05166-0.0160974
133Wnt signaling pathway_Homo sapiens_hsa04310-0.0010071

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