PDCD4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1signal peptide processing (GO:0006465)5.60432800
2negative regulation of phagocytosis (GO:0050765)5.50012536
3ribosomal small subunit assembly (GO:0000028)5.11257775
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.63283709
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.45654159
6antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.45654159
7cellular response to interleukin-15 (GO:0071350)4.37642651
8negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.35357201
9negative regulation of cell killing (GO:0031342)4.35357201
10regulation of B cell receptor signaling pathway (GO:0050855)4.33910873
11neutrophil mediated immunity (GO:0002446)4.02609924
12modulation of growth of symbiont involved in interaction with host (GO:0044144)3.98185696
13regulation of growth of symbiont in host (GO:0044126)3.98185696
14negative regulation of growth of symbiont in host (GO:0044130)3.98185696
15negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.98185696
16interferon-gamma production (GO:0032609)3.96758500
17keratinocyte development (GO:0003334)3.94976577
18positive regulation of gamma-delta T cell activation (GO:0046645)3.89959699
19response to interleukin-15 (GO:0070672)3.81786895
20antigen processing and presentation of endogenous antigen (GO:0019883)3.79481183
21fucose catabolic process (GO:0019317)3.77769403
22L-fucose metabolic process (GO:0042354)3.77769403
23L-fucose catabolic process (GO:0042355)3.77769403
24positive regulation of granulocyte differentiation (GO:0030854)3.77693082
25killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.71215237
26disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.71215237
27reactive oxygen species biosynthetic process (GO:1903409)3.63447264
28myeloid leukocyte mediated immunity (GO:0002444)3.59076181
29regulation of regulatory T cell differentiation (GO:0045589)3.56515166
30valine metabolic process (GO:0006573)3.41395325
31negative T cell selection (GO:0043383)3.37147599
32low-density lipoprotein particle remodeling (GO:0034374)3.31996863
33T-helper cell differentiation (GO:0042093)3.31970101
34CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.31970101
35generation of neurons (GO:0048699)3.30072013
36mast cell activation (GO:0045576)3.30015258
37tolerance induction (GO:0002507)3.26032480
38negative thymic T cell selection (GO:0045060)3.22743553
39regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.22035018
40maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.21246513
41negative regulation of execution phase of apoptosis (GO:1900118)3.20486413
42regulation of germinal center formation (GO:0002634)3.16791699
43B cell receptor signaling pathway (GO:0050853)3.15892123
44megakaryocyte development (GO:0035855)3.11752643
45dendritic cell chemotaxis (GO:0002407)3.11569333
46disruption of cells of other organism (GO:0044364)3.08762123
47killing of cells of other organism (GO:0031640)3.08762123
48DNA ligation (GO:0006266)3.08543347
49definitive hemopoiesis (GO:0060216)3.08285612
50regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.08019055
51positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.08019055
52protein retention in ER lumen (GO:0006621)3.07236474
53intestinal epithelial cell development (GO:0060576)3.04832335
54positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.01327784
55regulation of alpha-beta T cell proliferation (GO:0046640)2.99634970
56regulation of protein glycosylation (GO:0060049)2.96407582
57COPI coating of Golgi vesicle (GO:0048205)2.96204821
58Golgi transport vesicle coating (GO:0048200)2.96204821
59T cell differentiation involved in immune response (GO:0002292)2.89758201
60alpha-beta T cell differentiation involved in immune response (GO:0002293)2.89758201
61alpha-beta T cell activation involved in immune response (GO:0002287)2.89758201
62regulation of nuclear cell cycle DNA replication (GO:0033262)2.86270005
63androgen biosynthetic process (GO:0006702)2.85920831
64polyketide metabolic process (GO:0030638)2.85914678
65doxorubicin metabolic process (GO:0044598)2.85914678
66daunorubicin metabolic process (GO:0044597)2.85914678
67positive thymic T cell selection (GO:0045059)2.85435198
68regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.83194878
69positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.83194878
70positive regulation of B cell differentiation (GO:0045579)2.81747330
71regulation of T cell receptor signaling pathway (GO:0050856)2.81734382
72positive regulation of mRNA catabolic process (GO:0061014)2.80545283
73regulation of gamma-delta T cell activation (GO:0046643)2.79490095
74regulation of gamma-delta T cell differentiation (GO:0045586)2.78882046
75positive regulation of glycoprotein biosynthetic process (GO:0010560)2.77792580
76mast cell degranulation (GO:0043303)2.77738695
77mast cell activation involved in immune response (GO:0002279)2.77738695
78antigen receptor-mediated signaling pathway (GO:0050851)2.75949396
79cellular response to zinc ion (GO:0071294)2.74490042
80cytidine deamination (GO:0009972)2.73959923
81cytidine metabolic process (GO:0046087)2.73959923
82cytidine catabolic process (GO:0006216)2.73959923
83pyrimidine ribonucleoside catabolic process (GO:0046133)2.73801215
84protein targeting to Golgi (GO:0000042)2.73242822
85response to fungus (GO:0009620)2.72997023
86positive T cell selection (GO:0043368)2.72726940
87negative regulation of lymphocyte mediated immunity (GO:0002707)2.72278227
88protein K11-linked deubiquitination (GO:0035871)2.72118627
89S-adenosylmethionine metabolic process (GO:0046500)2.71274053
90positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.71081625
91CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.67996855
92type I interferon signaling pathway (GO:0060337)2.67655741
93cellular response to type I interferon (GO:0071357)2.67655741
94negative regulation of protein oligomerization (GO:0032460)2.67248807
95regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.67127174
96response to type I interferon (GO:0034340)2.66339264
97regulation of isotype switching to IgG isotypes (GO:0048302)2.65436867
98mitochondrial calcium ion transport (GO:0006851)2.64268700
99establishment of protein localization to Golgi (GO:0072600)2.63574239
100angiogenesis involved in wound healing (GO:0060055)2.63404806
101negative regulation of T cell mediated immunity (GO:0002710)2.63212514
102SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.62825631
103dendritic cell migration (GO:0036336)2.62634122
104type B pancreatic cell development (GO:0003323)2.61866151
105CD4-positive, alpha-beta T cell activation (GO:0035710)2.61813920
106phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.61780865
107positive regulation of respiratory burst (GO:0060267)2.60479134
108regulation of B cell differentiation (GO:0045577)2.59880841
109T cell selection (GO:0045058)2.59831296
110regulation of memory T cell differentiation (GO:0043380)2.58986482
111B cell homeostasis (GO:0001782)2.58524562
112T cell migration (GO:0072678)2.58047751
113positive regulation of cell killing (GO:0031343)2.57648428
114hepatocyte apoptotic process (GO:0097284)2.57205069
115regulation of leukocyte mediated cytotoxicity (GO:0001910)2.56839633
116defense response to fungus (GO:0050832)2.56457743
117cotranslational protein targeting to membrane (GO:0006613)2.56457035
118Arp2/3 complex-mediated actin nucleation (GO:0034314)2.54445655
119GDP-mannose metabolic process (GO:0019673)2.53938686
120protein targeting to ER (GO:0045047)2.52744960
121negative regulation of bone resorption (GO:0045779)2.51928639
122leukocyte degranulation (GO:0043299)2.51493339
123retrograde transport, vesicle recycling within Golgi (GO:0000301)2.51351224
124T cell receptor signaling pathway (GO:0050852)2.51311978
125negative regulation of erythrocyte differentiation (GO:0045647)2.50802331
126dentate gyrus development (GO:0021542)2.50672885
127alpha-beta T cell activation (GO:0046631)2.49613092
128protein localization to endoplasmic reticulum (GO:0070972)2.48046343
129cellular response to antibiotic (GO:0071236)2.47981367
130short-chain fatty acid metabolic process (GO:0046459)2.47360461
131T cell differentiation (GO:0030217)2.47339294
132response to interferon-beta (GO:0035456)2.47323615
133cellular ketone body metabolic process (GO:0046950)2.46718217
134regulation of T cell mediated cytotoxicity (GO:0001914)2.46243376
135regulation of cell killing (GO:0031341)2.45275101
136negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.45214255
137positive regulation of glycoprotein metabolic process (GO:1903020)2.44926230
138intra-Golgi vesicle-mediated transport (GO:0006891)2.44088468
139negative regulation of glycoprotein biosynthetic process (GO:0010561)2.43255206
140negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.43238209
141positive regulation of T cell mediated cytotoxicity (GO:0001916)2.42480290
142regulation of erythrocyte differentiation (GO:0045646)2.42284400
143Golgi to endosome transport (GO:0006895)2.42226407
144negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.42197594
145zinc ion homeostasis (GO:0055069)2.42031307
146positive regulation of T cell chemotaxis (GO:0010820)2.41971303
147regulation of T cell chemotaxis (GO:0010819)2.41971303
148interferon-gamma secretion (GO:0072643)2.41648707
149negative regulation of chemokine production (GO:0032682)2.41435206
150lymph node development (GO:0048535)2.40908768
151regulation of granulocyte differentiation (GO:0030852)2.40723721
152inositol phosphate catabolic process (GO:0071545)2.40366081
153ether lipid metabolic process (GO:0046485)2.40305134
154xenobiotic catabolic process (GO:0042178)2.39992134
155alpha-beta T cell differentiation (GO:0046632)2.39858646
156activated T cell proliferation (GO:0050798)2.39389118
157thymic T cell selection (GO:0045061)2.39319063
158cellular response to ethanol (GO:0071361)2.38946915
159response to folic acid (GO:0051593)2.38520954
160DNA deamination (GO:0045006)2.38362261
161glucose 6-phosphate metabolic process (GO:0051156)2.37980621
162V(D)J recombination (GO:0033151)2.37698906
163fucose metabolic process (GO:0006004)2.37601566
164cellular response to interferon-beta (GO:0035458)2.37519764
165nucleotide transmembrane transport (GO:1901679)2.37483287
166phosphorylated carbohydrate dephosphorylation (GO:0046838)2.37196606
167poly(A)+ mRNA export from nucleus (GO:0016973)2.36847603
168toxin transport (GO:1901998)2.36241784
169positive regulation of keratinocyte differentiation (GO:0045618)2.35113469
170platelet dense granule organization (GO:0060155)2.35030487
171establishment of protein localization to endoplasmic reticulum (GO:0072599)2.34000407
172regulation of respiratory burst (GO:0060263)2.33675028
173positive regulation of alpha-beta T cell proliferation (GO:0046641)2.33661747

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.72253456
2ELF1_17652178_ChIP-ChIP_JURKAT_Human4.41377581
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.93346839
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.61092466
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.58434602
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.38022201
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.32825790
8* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.79344010
9SCL_19346495_ChIP-Seq_HPC-7_Human2.75466951
10* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.53401697
11* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.52365752
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.51675621
13* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.45423648
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.45062981
15GATA1_22025678_ChIP-Seq_K562_Human2.39211067
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.34734157
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.29038233
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.19921003
19FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.17176089
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.16786912
21HOXB4_20404135_ChIP-ChIP_EML_Mouse2.16571308
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.13093316
23* MYB_26560356_Chip-Seq_TH2_Human2.09708715
24* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.08736320
25SMAD_19615063_ChIP-ChIP_OVARY_Human2.03715583
26* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.02030318
27IRF1_19129219_ChIP-ChIP_H3396_Human2.01777874
28BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.99963295
29EGR1_23403033_ChIP-Seq_LIVER_Mouse1.98961517
30TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.92900250
31EST1_17652178_ChIP-ChIP_JURKAT_Human1.92614592
32ERG_20887958_ChIP-Seq_HPC-7_Mouse1.90785061
33LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.89506763
34SPI1_23547873_ChIP-Seq_NB4_Human1.89217018
35RUNX_20019798_ChIP-Seq_JUKART_Human1.87105633
36MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.84329224
37ELK1_19687146_ChIP-ChIP_HELA_Human1.84048407
38* MYB_26560356_Chip-Seq_TH1_Human1.82831111
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.78920916
40FLI1_27457419_Chip-Seq_LIVER_Mouse1.77140324
41FOXP3_21729870_ChIP-Seq_TREG_Human1.77022369
42BP1_19119308_ChIP-ChIP_Hs578T_Human1.76491984
43NOTCH1_21737748_ChIP-Seq_TLL_Human1.74797042
44GABP_17652178_ChIP-ChIP_JURKAT_Human1.71524319
45* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.68141558
46SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.66595677
47STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.66189021
48PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65524668
49* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.62629448
50CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.61381924
51VDR_23849224_ChIP-Seq_CD4+_Human1.61210546
52FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.60750847
53* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.58372077
54PCGF2_27294783_Chip-Seq_ESCs_Mouse1.58027645
55GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.57673284
56IGF1R_20145208_ChIP-Seq_DFB_Human1.57396802
57E2F4_17652178_ChIP-ChIP_JURKAT_Human1.55801980
58ESR1_20079471_ChIP-ChIP_T-47D_Human1.54884102
59CDX2_19796622_ChIP-Seq_MESCs_Mouse1.53739540
60NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.52219982
61SRF_21415370_ChIP-Seq_HL-1_Mouse1.48004282
62IRF8_21731497_ChIP-ChIP_J774_Mouse1.46888716
63EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.44154756
64ER_23166858_ChIP-Seq_MCF-7_Human1.39482209
65CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.38644623
66* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.38331510
67* PU_27001747_Chip-Seq_BMDM_Mouse1.38115029
68HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.37780288
69AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.36894002
70FOXO3_23340844_ChIP-Seq_DLD1_Human1.36486037
71NFE2_27457419_Chip-Seq_LIVER_Mouse1.36221328
72CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.34880748
73FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.33866522
74GATA2_22383799_ChIP-Seq_G1ME_Mouse1.31538290
75HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.31447209
76PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.29866667
77AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.28540294
78CDX2_22108803_ChIP-Seq_LS180_Human1.27713535
79* RUNX1_22412390_ChIP-Seq_EML_Mouse1.24372672
80EZH2_27294783_Chip-Seq_NPCs_Mouse1.23538516
81MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.22352172
82IRF8_27001747_Chip-Seq_BMDM_Mouse1.22256628
83CIITA_25753668_ChIP-Seq_RAJI_Human1.21148194
84ZFP57_27257070_Chip-Seq_ESCs_Mouse1.20708805
85FOXA1_25552417_ChIP-Seq_VCAP_Human1.20297540
86* GATA3_26560356_Chip-Seq_TH2_Human1.20143147
87VDR_24763502_ChIP-Seq_THP-1_Human1.18528819
88FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.18184464
89JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.17792780
90FOXM1_26456572_ChIP-Seq_MCF-7_Human1.17746344
91PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17054769
92CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.16527848
93FOXA1_21572438_ChIP-Seq_LNCaP_Human1.15987232
94SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14210529
95ETS1_22383799_ChIP-Seq_G1ME_Mouse1.13994074
96FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.12987268
97DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.12371041
98POU3F2_20337985_ChIP-ChIP_501MEL_Human1.11602668
99VDR_22108803_ChIP-Seq_LS180_Human1.10228510
100BRD4_27068464_Chip-Seq_AML-cells_Mouse1.09952752
101ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09730274
102* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.09643703
103Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.07656197
104GATA3_26560356_Chip-Seq_TH1_Human1.06630046
105* GATA3_27048872_Chip-Seq_THYMUS_Human1.06352167
106ARNT_22903824_ChIP-Seq_MCF-7_Human1.05462232
107ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.05222330
108GATA4_25053715_ChIP-Seq_YYC3_Human1.04812506
109SMRT_27268052_Chip-Seq_Bcells_Human1.04590952
110MAF_26560356_Chip-Seq_TH1_Human1.04478117
111PADI4_21655091_ChIP-ChIP_MCF-7_Human1.04134236
112AHR_22903824_ChIP-Seq_MCF-7_Human1.03689159
113PCGF2_27294783_Chip-Seq_NPCs_Mouse1.03347405
114FUS_26573619_Chip-Seq_HEK293_Human1.03116611
115ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02507826
116RUNX1_27457419_Chip-Seq_LIVER_Mouse1.02120625
117FOXA1_27270436_Chip-Seq_PROSTATE_Human1.02044094
118FOXA1_25329375_ChIP-Seq_VCAP_Human1.02044094
119OCT4_21477851_ChIP-Seq_ESCs_Mouse1.01908425
120RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.01750017
121GATA1_22383799_ChIP-Seq_G1ME_Mouse1.01070729
122BCAT_22108803_ChIP-Seq_LS180_Human1.00306515
123STAT3_18555785_Chip-Seq_ESCs_Mouse0.98480888
124UTX_26944678_Chip-Seq_JUKART_Human0.98294534
125SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.97969516
126SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.97764902
127* GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.97468087
128TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.97293888
129TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96160714
130NANOG_18555785_Chip-Seq_ESCs_Mouse0.95337251
131AR_20517297_ChIP-Seq_VCAP_Human0.95044450
132NMYC_18555785_Chip-Seq_ESCs_Mouse0.93363785
133GATA2_21666600_ChIP-Seq_HMVEC_Human0.93305893
134VDR_24787735_ChIP-Seq_THP-1_Human0.93215539
135EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.92603089
136E2F1_21310950_ChIP-Seq_MCF-7_Human0.91166738
137PIAS1_25552417_ChIP-Seq_VCAP_Human0.90465406
138* SOX2_20726797_ChIP-Seq_SW620_Human0.90158525
139CMYC_18555785_Chip-Seq_ESCs_Mouse0.88986126
140E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.88726587
141PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.88614307
142* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.88287822
143OCT4_18555785_Chip-Seq_ESCs_Mouse0.88282771
144P53_22387025_ChIP-Seq_ESCs_Mouse0.88181743
145RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.87600439
146CRX_20693478_ChIP-Seq_RETINA_Mouse0.86915831
147SUZ12_18555785_Chip-Seq_ESCs_Mouse0.86586767
148CREB1_15753290_ChIP-ChIP_HEK293T_Human0.86080385
149VDR_21846776_ChIP-Seq_THP-1_Human0.85722384
150EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.85648915
151PU1_27457419_Chip-Seq_LIVER_Mouse0.83394513

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle3.82406527
2MP0003763_abnormal_thymus_physiology3.54035034
3MP0002396_abnormal_hematopoietic_system2.95249637
4MP0005671_abnormal_response_to2.63636826
5MP0001835_abnormal_antigen_presentation2.60405395
6* MP0002166_altered_tumor_susceptibility2.59709701
7MP0003724_increased_susceptibility_to2.36214138
8MP0002139_abnormal_hepatobiliary_system2.23782258
9MP0005075_abnormal_melanosome_morpholog2.21063119
10MP0002148_abnormal_hypersensitivity_rea2.20316740
11MP0003183_abnormal_peptide_metabolism2.20281599
12MP0009785_altered_susceptibility_to2.15828260
13MP0005365_abnormal_bile_salt2.14558654
14* MP0002006_tumorigenesis2.03666890
15MP0002876_abnormal_thyroid_physiology1.99461594
16MP0008057_abnormal_DNA_replication1.94842836
17MP0005645_abnormal_hypothalamus_physiol1.86750118
18MP0006292_abnormal_olfactory_placode1.84114258
19MP0009379_abnormal_foot_pigmentation1.78222009
20MP0004264_abnormal_extraembryonic_tissu1.76071080
21MP0005025_abnormal_response_to1.75267425
22MP0002420_abnormal_adaptive_immunity1.75104135
23MP0000685_abnormal_immune_system1.71099173
24MP0005387_immune_system_phenotype1.71053703
25MP0001790_abnormal_immune_system1.71053703
26MP0001819_abnormal_immune_cell1.70937563
27MP0001800_abnormal_humoral_immune1.70769953
28MP0002398_abnormal_bone_marrow1.70515186
29* MP0005000_abnormal_immune_tolerance1.69165336
30MP0001188_hyperpigmentation1.68875518
31MP0003195_calcinosis1.65766319
32MP0004808_abnormal_hematopoietic_stem1.63127335
33MP0005085_abnormal_gallbladder_physiolo1.60847831
34MP0005464_abnormal_platelet_physiology1.60519509
35MP0010155_abnormal_intestine_physiology1.60311858
36MP0001873_stomach_inflammation1.59766813
37MP0005379_endocrine/exocrine_gland_phen1.59368972
38MP0002419_abnormal_innate_immunity1.58914487
39MP0003436_decreased_susceptibility_to1.58285199
40MP0002877_abnormal_melanocyte_morpholog1.57416848
41MP0004381_abnormal_hair_follicle1.55193213
42MP0009333_abnormal_splenocyte_physiolog1.52600164
43MP0002138_abnormal_hepatobiliary_system1.50439115
44* MP0002723_abnormal_immune_serum1.50186453
45MP0002693_abnormal_pancreas_physiology1.49702271
46MP0000716_abnormal_immune_system1.49304806
47MP0005174_abnormal_tail_pigmentation1.48471029
48MP0010678_abnormal_skin_adnexa1.48054886
49MP0000490_abnormal_crypts_of1.48045890
50MP0005220_abnormal_exocrine_pancreas1.47561846
51MP0003787_abnormal_imprinting1.46679922
52MP0002452_abnormal_antigen_presenting1.43523015
53MP0003300_gastrointestinal_ulcer1.42979664
54MP0002722_abnormal_immune_system1.42910260
55MP0001764_abnormal_homeostasis1.42720807
56* MP0002009_preneoplasia1.40986224
57MP0002909_abnormal_adrenal_gland1.39847394
58MP0000858_altered_metastatic_potential1.38712193
59MP0003866_abnormal_defecation1.38636755
60MP0003868_abnormal_feces_composition1.38352617
61MP0005084_abnormal_gallbladder_morpholo1.37774954
62MP0000689_abnormal_spleen_morphology1.37568634
63MP0002163_abnormal_gland_morphology1.36898106
64MP0001545_abnormal_hematopoietic_system1.36040288
65MP0005397_hematopoietic_system_phenotyp1.36040288
66MP0006054_spinal_hemorrhage1.34550571
67MP0001666_abnormal_nutrient_absorption1.34465991
68MP0005310_abnormal_salivary_gland1.34436728
69MP0001986_abnormal_taste_sensitivity1.34318147
70MP0004043_abnormal_pH_regulation1.33850499
71MP0001845_abnormal_inflammatory_respons1.33528069
72MP0000703_abnormal_thymus_morphology1.33022345
73MP0005409_darkened_coat_color1.31270009
74MP0003943_abnormal_hepatobiliary_system1.30015928
75MP0000372_irregular_coat_pigmentation1.29763384
76MP0002405_respiratory_system_inflammati1.29385050
77MP0000465_gastrointestinal_hemorrhage1.27235734
78MP0002095_abnormal_skin_pigmentation1.26435028
79MP0000427_abnormal_hair_cycle1.23676581
80MP0005408_hypopigmentation1.23432896
81MP0000015_abnormal_ear_pigmentation1.23303988
82MP0002429_abnormal_blood_cell1.22043525
83MP0004782_abnormal_surfactant_physiolog1.21843412
84MP0008961_abnormal_basal_metabolism1.21677166
85MP0008058_abnormal_DNA_repair1.21515536
86MP0001765_abnormal_ion_homeostasis1.21029879
87MP0002132_abnormal_respiratory_system1.20942102
88MP0009697_abnormal_copulation1.19400122
89MP0000678_abnormal_parathyroid_gland1.18300937
90MP0010329_abnormal_lipoprotein_level1.17041625
91MP0002254_reproductive_system_inflammat1.16740986
92MP0001944_abnormal_pancreas_morphology1.15150396
93MP0008007_abnormal_cellular_replicative1.14524656
94MP0002837_dystrophic_cardiac_calcinosis1.14338895
95MP0000013_abnormal_adipose_tissue1.14093640
96MP0009780_abnormal_chondrocyte_physiolo1.13099824
97MP0010094_abnormal_chromosome_stability1.12934196
98MP0008995_early_reproductive_senescence1.12374298
99MP0003045_fibrosis1.10725639
100MP0002928_abnormal_bile_duct1.06754955
101MP0005636_abnormal_mineral_homeostasis1.04720325
102MP0001853_heart_inflammation1.02138672
103MP0009643_abnormal_urine_homeostasis1.01724164
104MP0001919_abnormal_reproductive_system1.01599813
105MP0003186_abnormal_redox_activity1.00710006
106MP0008469_abnormal_protein_level0.97288563
107MP0000613_abnormal_salivary_gland0.95717478
108MP0009765_abnormal_xenobiotic_induced0.93311554
109MP0001346_abnormal_lacrimal_gland0.92820095
110MP0001881_abnormal_mammary_gland0.91992829
111MP0002933_joint_inflammation0.91047936
112MP0002638_abnormal_pupillary_reflex0.90204486
113MP0005646_abnormal_pituitary_gland0.89741260
114MP0002277_abnormal_respiratory_mucosa0.87069799
115MP0004947_skin_inflammation0.86474053
116MP0002796_impaired_skin_barrier0.86220625
117MP0003172_abnormal_lysosome_physiology0.85649815
118MP0002136_abnormal_kidney_physiology0.85178110
119* MP0002019_abnormal_tumor_incidence0.85087077
120MP0000609_abnormal_liver_physiology0.82804341
121MP0003693_abnormal_embryo_hatching0.81781494
122MP0000383_abnormal_hair_follicle0.81668509
123MP0008877_abnormal_DNA_methylation0.81556617
124MP0001186_pigmentation_phenotype0.81519985
125MP0004147_increased_porphyrin_level0.79587776
126MP0003786_premature_aging0.79126417
127MP0009763_increased_sensitivity_to0.78699997
128MP0003656_abnormal_erythrocyte_physiolo0.78380331
129MP0002078_abnormal_glucose_homeostasis0.78337175
130MP0000681_abnormal_thyroid_gland0.77897957
131MP0003252_abnormal_bile_duct0.76328055

Predicted human phenotypes

RankGene SetZ-score
1Thrombocytosis (HP:0001894)5.01980784
2Reduced antithrombin III activity (HP:0001976)4.68435301
3Type I transferrin isoform profile (HP:0003642)4.38112455
4Stomatitis (HP:0010280)3.73398787
5Abnormal protein glycosylation (HP:0012346)3.64290619
6Abnormal glycosylation (HP:0012345)3.64290619
7Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.64290619
8Abnormal protein N-linked glycosylation (HP:0012347)3.64290619
9Aplastic anemia (HP:0001915)3.39276119
10Hypoplasia of the thymus (HP:0000778)3.26351664
11Eosinophilia (HP:0001880)3.24910950
12Abnormal delayed hypersensitivity skin test (HP:0002963)3.18434890
13Granulocytopenia (HP:0001913)3.15562453
14Periodontitis (HP:0000704)3.10962297
15Abnormal number of erythroid precursors (HP:0012131)3.09112810
16Abnormality of T cell number (HP:0011839)3.04130967
17Hematochezia (HP:0002573)3.00570474
18Abnormality of the prostate (HP:0008775)2.96388559
19Conjugated hyperbilirubinemia (HP:0002908)2.94688305
20Prolonged partial thromboplastin time (HP:0003645)2.93403214
21Abnormality of the fingertips (HP:0001211)2.91218441
22Abnormality of eosinophils (HP:0001879)2.90643826
23Abnormality of T cell physiology (HP:0011840)2.89355480
24Abnormality of the intrinsic pathway (HP:0010989)2.87679825
25Petechiae (HP:0000967)2.86081695
2611 pairs of ribs (HP:0000878)2.85893242
27T lymphocytopenia (HP:0005403)2.84331888
28Chronic otitis media (HP:0000389)2.83567651
29Abnormality of T cells (HP:0002843)2.81567086
30Myositis (HP:0100614)2.79239108
31Eczematoid dermatitis (HP:0000976)2.73297176
32Renal cortical cysts (HP:0000803)2.72173723
33Increased IgE level (HP:0003212)2.68906642
34Hypochromic anemia (HP:0001931)2.67549224
35Pustule (HP:0200039)2.67494310
36Ketoacidosis (HP:0001993)2.67418808
37Abnormality of vitamin B metabolism (HP:0004340)2.62443604
38Autoimmune hemolytic anemia (HP:0001890)2.57936333
39Abnormality of cells of the erythroid lineage (HP:0012130)2.57526294
40Hypothermia (HP:0002045)2.56234328
41Meningitis (HP:0001287)2.55706966
42Severe combined immunodeficiency (HP:0004430)2.55181387
43Hypoproteinemia (HP:0003075)2.54482932
44Conjunctival hamartoma (HP:0100780)2.54124279
45Epistaxis (HP:0000421)2.53303011
46Stomach cancer (HP:0012126)2.51981284
47Abnormality of B cell number (HP:0010975)2.49801997
48B lymphocytopenia (HP:0010976)2.49801997
49Increased CSF protein (HP:0002922)2.49326387
50IgM deficiency (HP:0002850)2.46061643
51Prolonged bleeding time (HP:0003010)2.45951417
52Thyroiditis (HP:0100646)2.45683792
53Joint hemorrhage (HP:0005261)2.44726130
54IgG deficiency (HP:0004315)2.44003773
55Encephalitis (HP:0002383)2.43022903
56Keratoconjunctivitis sicca (HP:0001097)2.39896501
57Joint swelling (HP:0001386)2.35962429
58Neutropenia (HP:0001875)2.33327590
59Leukocytosis (HP:0001974)2.32323491
60Recurrent viral infections (HP:0004429)2.31709760
61Autoimmune thrombocytopenia (HP:0001973)2.29024607
62Retrobulbar optic neuritis (HP:0100654)2.27157342
63Optic neuritis (HP:0100653)2.27157342
64Recurrent sinusitis (HP:0011108)2.26724650
65Keratoconjunctivitis (HP:0001096)2.25410040
66Recurrent bronchitis (HP:0002837)2.25111954
67Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.24917165
68Panhypogammaglobulinemia (HP:0003139)2.23992868
69Elevated erythrocyte sedimentation rate (HP:0003565)2.23296932
70Abnormality of the renal cortex (HP:0011035)2.22812770
71Bronchitis (HP:0012387)2.22740730
72Inflammation of the large intestine (HP:0002037)2.21933366
73Lip pit (HP:0100267)2.21832675
74Palmoplantar hyperkeratosis (HP:0000972)2.20146934
75Testicular neoplasm (HP:0010788)2.19541555
76Combined immunodeficiency (HP:0005387)2.18048819
77Generalized aminoaciduria (HP:0002909)2.17804181
78Palmar hyperkeratosis (HP:0010765)2.17331376
79Limb hypertonia (HP:0002509)2.17282612
80Agammaglobulinemia (HP:0004432)2.17010372
81Orchitis (HP:0100796)2.16729583
82Abnormality of small intestinal villus morphology (HP:0011472)2.15878893
83Villous atrophy (HP:0011473)2.15878893
84Prostate neoplasm (HP:0100787)2.15645975
85Papilloma (HP:0012740)2.15328771
86Verrucae (HP:0200043)2.15328771
87Recurrent fungal infections (HP:0002841)2.14608294
88Ketosis (HP:0001946)2.14539587
89Abnormality of the common coagulation pathway (HP:0010990)2.14384331
90Hypochromic microcytic anemia (HP:0004840)2.13991457
91Recurrent cutaneous fungal infections (HP:0011370)2.13083970
92Chronic mucocutaneous candidiasis (HP:0002728)2.13083970
93Albinism (HP:0001022)2.10767608
94Increased IgM level (HP:0003496)2.10152848
95Abnormality of aromatic amino acid family metabolism (HP:0004338)2.08674757
96Chronic sinusitis (HP:0011109)2.08254506
97Abnormality of the heme biosynthetic pathway (HP:0010472)2.08147536
98Hypergammaglobulinemia (HP:0010702)2.06176169
99Hyperbilirubinemia (HP:0002904)2.04626171
100Hypoglycemic coma (HP:0001325)2.03415653
101Abnormality of the vitamin B12 metabolism (HP:0004341)2.02971415
102Hamartoma of the eye (HP:0010568)2.02132858
103Metaphyseal dysplasia (HP:0100255)2.01064690
104Abnormal hair whorl (HP:0010721)2.00546848
105Pulmonary infiltrates (HP:0002113)2.00229364
106Hyperglycemia (HP:0003074)1.99918861
107Nasal polyposis (HP:0100582)1.98895796
108Abnormality of secondary sexual hair (HP:0009888)1.98323998
109Abnormality of the axillary hair (HP:0100134)1.98323998
110True hermaphroditism (HP:0010459)1.98159638
111Gastrointestinal inflammation (HP:0004386)1.97570261
112Hyperactive renin-angiotensin system (HP:0000841)1.97410167
113Vacuolated lymphocytes (HP:0001922)1.96496086
114Gastrointestinal infarctions (HP:0005244)1.94940897
115Pancreatic islet-cell hyperplasia (HP:0004510)1.93824613
116Metabolic alkalosis (HP:0200114)1.92301807
117Abnormality of male internal genitalia (HP:0000022)1.92280043
118Gastrointestinal stroma tumor (HP:0100723)1.91562899
119Alveolar cell carcinoma (HP:0006519)1.91273425
120Arterial thrombosis (HP:0004420)1.91105599
121Menorrhagia (HP:0000132)1.90566123
122Acute hepatic failure (HP:0006554)1.89683881
123Lymphopenia (HP:0001888)1.88383808
124Symptomatic seizures (HP:0011145)1.88300783
125Abnormal platelet volume (HP:0011876)1.88245173
126Vasculitis (HP:0002633)1.87847297
127Decreased circulating renin level (HP:0003351)1.87662458
128Gingival bleeding (HP:0000225)1.87521147
129Recurrent skin infections (HP:0001581)1.87237818
130Anhidrosis (HP:0000970)1.87135348
131Absent rod-and cone-mediated responses on ERG (HP:0007688)1.86722099
132Abnormality of endocrine pancreas physiology (HP:0012093)1.86307596
133Abnormality of the pancreatic islet cells (HP:0006476)1.86307596
134Abnormal biliary tract morphology (HP:0012440)1.85814118
135Hemoptysis (HP:0002105)1.85534371
136Thyroid carcinoma (HP:0002890)1.84651208
137Recurrent bacterial skin infections (HP:0005406)1.83470325
138Bronchiectasis (HP:0002110)1.83375096
139Nonimmune hydrops fetalis (HP:0001790)1.82216358
140Chronic diarrhea (HP:0002028)1.81922390
141Clubbing of toes (HP:0100760)1.81252267
142Abnormality of vitamin metabolism (HP:0100508)1.79158600
143Exocrine pancreatic insufficiency (HP:0001738)1.77345769
144Keratitis (HP:0000491)1.77029022
145Papilledema (HP:0001085)1.76778181
146Hypoglycemic seizures (HP:0002173)1.76085269
147Hyperinsulinemic hypoglycemia (HP:0000825)1.75439363
148Optic nerve coloboma (HP:0000588)1.75178356
149Generalized hypopigmentation of hair (HP:0011358)1.75154471
150Plantar hyperkeratosis (HP:0007556)1.74138729
151Volvulus (HP:0002580)1.74123266
152Neoplasm of the tracheobronchial system (HP:0100552)1.73306076
153Abnormality of cells of the lymphoid lineage (HP:0012140)1.69142951
154Methylmalonic acidemia (HP:0002912)1.68585302

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK3.59592796
2IRAK43.18408112
3FRK3.01246343
4TAOK32.60427785
5MAP3K142.60222770
6TEC2.50089923
7STK162.44729957
8STK242.22382315
9EIF2AK32.09008635
10MAP3K122.03559609
11CASK1.97288468
12IRAK31.94729763
13MKNK21.90955032
14MAP4K11.90266132
15IKBKE1.90188588
16PASK1.83354956
17NLK1.79941459
18ZAP701.74331180
19MAP4K21.71716047
20SGK21.70386989
21BTK1.65257428
22MST41.63455463
23FER1.62612731
24FGFR21.61903401
25CAMKK21.59948449
26ITK1.53318992
27ZAK1.48979644
28EPHA31.48792568
29SRPK11.43040017
30SIK31.42680274
31MKNK11.40082452
32CLK11.37692131
33AKT31.36836215
34PIM11.36605701
35PRPF4B1.34459845
36JAK31.34325316
37FGFR31.33727272
38GRK61.32542035
39INSRR1.32343488
40HIPK21.30722754
41PIM21.29179240
42EIF2AK21.28921449
43NUAK11.25792968
44MAP2K21.24081704
45CDK81.23515859
46TNIK1.20768877
47CHUK1.20336051
48BMPR21.19837689
49MAPKAPK31.19321893
50VRK11.15945668
51JAK11.15803423
52MAP3K21.14152953
53FLT31.13596893
54YES11.09645955
55IRAK11.07669968
56SYK1.05975867
57SCYL21.01502043
58RPS6KC11.01260169
59RPS6KL11.01260169
60PIK3CG1.00841163
61RPS6KA60.99747207
62KIT0.98642266
63STK390.96544801
64SGK30.95821760
65TNK20.95090918
66NME20.94985253
67IKBKB0.91867538
68CSF1R0.91642719
69MAP2K60.91244834
70PAK30.89215441
71MYLK0.84752102
72JAK20.83318371
73RIPK40.82245307
74TYK20.81473852
75HCK0.81020958
76LCK0.78825352
77IRAK20.78646896
78TRPM70.75860092
79ACVR1B0.73143407
80MAPK150.72563486
81ADRBK20.71583247
82CDK70.70059534
83ERBB30.68578112
84MUSK0.68442134
85SGK2230.67866865
86SGK4940.67866865
87NEK90.66235851
88LYN0.64304931
89ATR0.64211951
90BMPR1B0.63225473
91CDK30.60998204
92BRD40.60966799
93RPS6KA20.60715219
94* RPS6KB10.59494983
95OXSR10.59466732
96MAPK70.58286307
97PRKAA20.58005848
98MAP2K70.56878120
99GRK10.56003489
100BLK0.55896001
101TBK10.55364535
102MARK30.54353147
103TSSK60.53747790
104STK30.53347621
105NEK60.52415938
106TGFBR20.48301962
107MAP3K130.47903052
108PRKD20.47508911
109FES0.47170991
110TRIM280.47001138
111BCKDK0.46918996
112MAPK110.46254457
113IGF1R0.46197689
114PRKCE0.45473708
115PRKCQ0.44704936
116DAPK10.43709451
117ABL10.43002903
118ERN10.42436934
119BCR0.41718217
120CSK0.41616179
121STK100.41414167
122BRSK20.40763555
123PIK3CA0.38067204
124RPS6KB20.37510006
125MATK0.37259758
126CDK60.37246158
127LRRK20.37151953
128PRKG20.35920010
129PTK2B0.34452121
130MAPK30.33744674
131EIF2AK10.32851367
132FGFR40.32751876
133GRK50.31843668
134MAP2K10.31172054
135CAMKK10.29924592
136STK38L0.26802324

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030605.05954183
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.49093971
3Primary immunodeficiency_Homo sapiens_hsa053402.95334518
4DNA replication_Homo sapiens_hsa030302.19579373
5Sulfur metabolism_Homo sapiens_hsa009202.14979988
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.00794581
7Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.93872874
8Measles_Homo sapiens_hsa051621.87072302
9Ribosome_Homo sapiens_hsa030101.86749384
10Pentose and glucuronate interconversions_Homo sapiens_hsa000401.85353354
11Nitrogen metabolism_Homo sapiens_hsa009101.83664815
12N-Glycan biosynthesis_Homo sapiens_hsa005101.80745206
13Non-homologous end-joining_Homo sapiens_hsa034501.79157345
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.68763808
15Antigen processing and presentation_Homo sapiens_hsa046121.68167855
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.68033867
17Circadian rhythm_Homo sapiens_hsa047101.66650588
18Base excision repair_Homo sapiens_hsa034101.65151214
19Galactose metabolism_Homo sapiens_hsa000521.61911270
20Homologous recombination_Homo sapiens_hsa034401.60561882
21Other glycan degradation_Homo sapiens_hsa005111.55830853
22Allograft rejection_Homo sapiens_hsa053301.54461059
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.53706084
24Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.50955365
25Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.48766470
26Primary bile acid biosynthesis_Homo sapiens_hsa001201.48477308
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.46352567
28Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.41921202
29Mismatch repair_Homo sapiens_hsa034301.41721175
30Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.41458537
31Linoleic acid metabolism_Homo sapiens_hsa005911.40786160
32RNA degradation_Homo sapiens_hsa030181.39045624
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.37533614
34Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.33118027
35Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.32903929
36Fatty acid elongation_Homo sapiens_hsa000621.30285930
37Butanoate metabolism_Homo sapiens_hsa006501.29574490
38Folate biosynthesis_Homo sapiens_hsa007901.29550398
39ABC transporters_Homo sapiens_hsa020101.28403951
40NF-kappa B signaling pathway_Homo sapiens_hsa040641.26336781
41Steroid hormone biosynthesis_Homo sapiens_hsa001401.26129501
42Regulation of autophagy_Homo sapiens_hsa041401.25856577
43Starch and sucrose metabolism_Homo sapiens_hsa005001.23214010
44Hematopoietic cell lineage_Homo sapiens_hsa046401.22002276
45SNARE interactions in vesicular transport_Homo sapiens_hsa041301.21689070
46Propanoate metabolism_Homo sapiens_hsa006401.21571133
47Herpes simplex infection_Homo sapiens_hsa051681.21508216
48RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.20901792
49One carbon pool by folate_Homo sapiens_hsa006701.20074244
50Peroxisome_Homo sapiens_hsa041461.17568863
51Autoimmune thyroid disease_Homo sapiens_hsa053201.17211708
52Graft-versus-host disease_Homo sapiens_hsa053321.16487217
53Fanconi anemia pathway_Homo sapiens_hsa034601.14035125
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.13346220
55Fat digestion and absorption_Homo sapiens_hsa049751.10129521
56Chemical carcinogenesis_Homo sapiens_hsa052041.09368183
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.07313518
58Pancreatic secretion_Homo sapiens_hsa049721.07160176
59Ether lipid metabolism_Homo sapiens_hsa005651.05194182
60Selenocompound metabolism_Homo sapiens_hsa004501.04301567
61Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.02118685
62Transcriptional misregulation in cancer_Homo sapiens_hsa052021.01911390
63T cell receptor signaling pathway_Homo sapiens_hsa046600.98922424
64Basal transcription factors_Homo sapiens_hsa030220.97248673
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.96177561
66Nucleotide excision repair_Homo sapiens_hsa034200.92640932
67Drug metabolism - other enzymes_Homo sapiens_hsa009830.90943377
68Leishmaniasis_Homo sapiens_hsa051400.89111146
69Renin-angiotensin system_Homo sapiens_hsa046140.88365970
70Jak-STAT signaling pathway_Homo sapiens_hsa046300.88239968
71Influenza A_Homo sapiens_hsa051640.85788582
72Thyroid cancer_Homo sapiens_hsa052160.85356043
73Staphylococcus aureus infection_Homo sapiens_hsa051500.85037718
74Mineral absorption_Homo sapiens_hsa049780.82687942
75Spliceosome_Homo sapiens_hsa030400.82639250
76p53 signaling pathway_Homo sapiens_hsa041150.81901024
77Pyrimidine metabolism_Homo sapiens_hsa002400.80061616
78Arachidonic acid metabolism_Homo sapiens_hsa005900.79521461
79Inositol phosphate metabolism_Homo sapiens_hsa005620.78555762
80Histidine metabolism_Homo sapiens_hsa003400.77328850
81Fatty acid metabolism_Homo sapiens_hsa012120.76954070
82Tryptophan metabolism_Homo sapiens_hsa003800.75159547
83Renin secretion_Homo sapiens_hsa049240.74288791
84Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.71131689
85Pentose phosphate pathway_Homo sapiens_hsa000300.70948337
86Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.70932538
87Fatty acid degradation_Homo sapiens_hsa000710.70862228
88Retinol metabolism_Homo sapiens_hsa008300.70775000
89Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.68919905
90Glycerophospholipid metabolism_Homo sapiens_hsa005640.67803225
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.66741043
92Rheumatoid arthritis_Homo sapiens_hsa053230.65888539
93Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.65577002
94Caffeine metabolism_Homo sapiens_hsa002320.65187918
95Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.64830435
96TNF signaling pathway_Homo sapiens_hsa046680.63332709
97Insulin resistance_Homo sapiens_hsa049310.63328853
98Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.63020647
99Type I diabetes mellitus_Homo sapiens_hsa049400.63017319
100Hepatitis B_Homo sapiens_hsa051610.62580296
101NOD-like receptor signaling pathway_Homo sapiens_hsa046210.62308328
102Phosphatidylinositol signaling system_Homo sapiens_hsa040700.60845046
103Legionellosis_Homo sapiens_hsa051340.60138470
104Glycerolipid metabolism_Homo sapiens_hsa005610.59139997
105FoxO signaling pathway_Homo sapiens_hsa040680.57953776
106mTOR signaling pathway_Homo sapiens_hsa041500.57876825
107Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57191672
108Dorso-ventral axis formation_Homo sapiens_hsa043200.56670519
109Viral myocarditis_Homo sapiens_hsa054160.54477097
110Glutathione metabolism_Homo sapiens_hsa004800.53895586
111Tuberculosis_Homo sapiens_hsa051520.53761247
112Asthma_Homo sapiens_hsa053100.51962217
113Cell cycle_Homo sapiens_hsa041100.51869021
114RNA polymerase_Homo sapiens_hsa030200.51579691
115Purine metabolism_Homo sapiens_hsa002300.51288619
116Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50572546
117Platelet activation_Homo sapiens_hsa046110.49346637
118Acute myeloid leukemia_Homo sapiens_hsa052210.48730487
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48005355
120Leukocyte transendothelial migration_Homo sapiens_hsa046700.45266369
121Sulfur relay system_Homo sapiens_hsa041220.45069565
122Toxoplasmosis_Homo sapiens_hsa051450.44974439
123Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44087578
124Cyanoamino acid metabolism_Homo sapiens_hsa004600.43337441
125Toll-like receptor signaling pathway_Homo sapiens_hsa046200.42567432
126Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.42185392
127Vitamin digestion and absorption_Homo sapiens_hsa049770.42050638
128Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.41911982
129Chemokine signaling pathway_Homo sapiens_hsa040620.41491216
130Complement and coagulation cascades_Homo sapiens_hsa046100.40624096
131Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39510670
132Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.39340672
133Osteoclast differentiation_Homo sapiens_hsa043800.37462663
134Hepatitis C_Homo sapiens_hsa051600.36966569
135Sphingolipid metabolism_Homo sapiens_hsa006000.36650247
136Prolactin signaling pathway_Homo sapiens_hsa049170.35069569
137Pertussis_Homo sapiens_hsa051330.34109790
138Metabolic pathways_Homo sapiens_hsa011000.33922867
139Prostate cancer_Homo sapiens_hsa052150.33726475
140B cell receptor signaling pathway_Homo sapiens_hsa046620.32446682

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