PDAP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a phosphoprotein that may upregulate the PDGFA-stimulated growth of fibroblasts and also downregulate the mitogenicity of PDGFB. The encoded protein in rodents has been shown to bind PDGFA with a low affinity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)7.03387684
2ribosomal small subunit biogenesis (GO:0042274)7.03077011
3translational termination (GO:0006415)6.78214582
4maturation of SSU-rRNA (GO:0030490)5.82349254
5translational elongation (GO:0006414)5.56436049
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.55890405
7cotranslational protein targeting to membrane (GO:0006613)5.55393002
8protein targeting to ER (GO:0045047)5.52458294
9cellular protein complex disassembly (GO:0043624)5.47819810
10nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.40569251
11establishment of protein localization to endoplasmic reticulum (GO:0072599)5.33491114
12translational initiation (GO:0006413)5.28971478
13viral life cycle (GO:0019058)5.28012472
14protein localization to endoplasmic reticulum (GO:0070972)5.08355491
15protein complex disassembly (GO:0043241)4.90441249
16mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.84237526
17ribosomal large subunit biogenesis (GO:0042273)4.81507360
18ATP synthesis coupled proton transport (GO:0015986)4.68237622
19energy coupled proton transport, down electrochemical gradient (GO:0015985)4.68237622
20macromolecular complex disassembly (GO:0032984)4.61909183
21mitotic chromosome condensation (GO:0007076)4.57489789
22regulation of translational fidelity (GO:0006450)4.31188808
23establishment of protein localization to mitochondrial membrane (GO:0090151)4.21348149
24establishment of integrated proviral latency (GO:0075713)4.15390692
25spliceosomal complex assembly (GO:0000245)3.85603736
26ribosomal small subunit assembly (GO:0000028)3.81716772
27translation (GO:0006412)3.79753314
28ribonucleoprotein complex biogenesis (GO:0022613)3.75986930
29nuclear-transcribed mRNA catabolic process (GO:0000956)3.75055047
30protein targeting to membrane (GO:0006612)3.73016950
31mitotic nuclear envelope reassembly (GO:0007084)3.66278898
32nuclear envelope reassembly (GO:0031468)3.66278898
33nucleobase-containing small molecule interconversion (GO:0015949)3.64440183
34regulation of translational termination (GO:0006449)3.58483729
35spliceosomal snRNP assembly (GO:0000387)3.54969147
36mRNA catabolic process (GO:0006402)3.51051880
37protein complex localization (GO:0031503)3.47175352
38proline biosynthetic process (GO:0006561)3.46411941
39Golgi transport vesicle coating (GO:0048200)3.46357967
40COPI coating of Golgi vesicle (GO:0048205)3.46357967
41regulation of mammary gland epithelial cell proliferation (GO:0033599)3.46279657
42mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.39234194
43DNA strand elongation (GO:0022616)3.38806115
44ribosome biogenesis (GO:0042254)3.35869287
45DNA damage response, detection of DNA damage (GO:0042769)3.35376642
46planar cell polarity pathway involved in neural tube closure (GO:0090179)3.31861169
47RNA catabolic process (GO:0006401)3.31709325
48negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.30559378
49peptidyl-arginine omega-N-methylation (GO:0035247)3.29012614
50protein neddylation (GO:0045116)3.27392968
51cellular protein complex localization (GO:0034629)3.24084469
52rRNA processing (GO:0006364)3.23444945
53protein maturation by protein folding (GO:0022417)3.13503964
54establishment of viral latency (GO:0019043)3.12981554
55rRNA metabolic process (GO:0016072)3.11821977
56pentose-phosphate shunt (GO:0006098)3.10713071
57mitotic metaphase plate congression (GO:0007080)3.08983708
58protein retention in ER lumen (GO:0006621)3.07003527
59formation of translation preinitiation complex (GO:0001731)3.05833943
60histone arginine methylation (GO:0034969)3.04443398
61maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.04119567
62nucleosome disassembly (GO:0006337)3.01398203
63protein-DNA complex disassembly (GO:0032986)3.01398203
64protein localization to chromosome, centromeric region (GO:0071459)3.00406595
65UTP biosynthetic process (GO:0006228)2.99092149
66positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.98418756
67respiratory electron transport chain (GO:0022904)2.93657546
68paraxial mesoderm development (GO:0048339)2.93531950
69chromosome condensation (GO:0030261)2.90800378
70DNA unwinding involved in DNA replication (GO:0006268)2.90402055
71telomere maintenance via semi-conservative replication (GO:0032201)2.89678218
72regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.88614557
73cell fate commitment involved in formation of primary germ layer (GO:0060795)2.87933747
74DNA replication initiation (GO:0006270)2.86315542
75cellular component biogenesis (GO:0044085)2.86265329
76electron transport chain (GO:0022900)2.85698949
77nuclear pore complex assembly (GO:0051292)2.84741441
78regulation of posttranscriptional gene silencing (GO:0060147)2.82316713
79regulation of gene silencing by miRNA (GO:0060964)2.82316713
80regulation of gene silencing by RNA (GO:0060966)2.82316713
81mitochondrial fusion (GO:0008053)2.82219230
82negative regulation of RNA splicing (GO:0033119)2.77707745
83regulation of mitochondrial translation (GO:0070129)2.77658409
84GTP biosynthetic process (GO:0006183)2.76461847
85lateral sprouting from an epithelium (GO:0060601)2.74992025
86microtubule depolymerization (GO:0007019)2.74361944
87regulation of glucose import in response to insulin stimulus (GO:2001273)2.73561976
88RNA splicing, via transesterification reactions (GO:0000375)2.73501884
89RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.72838038
90mRNA splicing, via spliceosome (GO:0000398)2.72838038
91DNA replication-dependent nucleosome organization (GO:0034723)2.72645016
92DNA replication-dependent nucleosome assembly (GO:0006335)2.72645016
93L-serine metabolic process (GO:0006563)2.70467535
94mRNA stabilization (GO:0048255)2.70305312
95RNA stabilization (GO:0043489)2.70305312
96establishment of protein localization to membrane (GO:0090150)2.69668568
97rRNA transcription (GO:0009303)2.68883814
98sister chromatid segregation (GO:0000819)2.68002218
99maternal placenta development (GO:0001893)2.67952593
100regulation of RNA export from nucleus (GO:0046831)2.67724018
101DNA topological change (GO:0006265)2.67357369
102NADPH regeneration (GO:0006740)2.67220413
103peptidyl-arginine methylation (GO:0018216)2.66728883
104peptidyl-arginine N-methylation (GO:0035246)2.66728883
105regulation of mitotic spindle organization (GO:0060236)2.66194883
106protein localization to microtubule (GO:0035372)2.65052618
107heterochromatin organization (GO:0070828)2.64385999
108termination of RNA polymerase II transcription (GO:0006369)2.63838006
109adherens junction assembly (GO:0034333)2.63836311
110cell-substrate adherens junction assembly (GO:0007045)2.61599122
111focal adhesion assembly (GO:0048041)2.61599122
112negative regulation of microtubule polymerization (GO:0031115)2.60847903
113retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.60792606
114kinetochore organization (GO:0051383)2.59960829
115positive regulation of viral transcription (GO:0050434)2.59860046
116negative regulation of mRNA metabolic process (GO:1903312)2.55970714
117regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.55557945
118mitotic G1 DNA damage checkpoint (GO:0031571)2.54960449
119negative regulation of mRNA processing (GO:0050686)2.54085185
120termination of RNA polymerase III transcription (GO:0006386)2.53472770
121transcription elongation from RNA polymerase III promoter (GO:0006385)2.53472770
122folic acid-containing compound biosynthetic process (GO:0009396)2.53028623
123positive regulation of DNA-dependent DNA replication (GO:2000105)2.52831953
124regulation of transcription from RNA polymerase I promoter (GO:0006356)2.52764199
125glucose 6-phosphate metabolic process (GO:0051156)2.52203673
126glucose catabolic process (GO:0006007)2.51697241
127negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.51310480
128regulation of early endosome to late endosome transport (GO:2000641)2.50504355
129negative regulation of DNA-templated transcription, elongation (GO:0032785)2.50286653
130kinetochore assembly (GO:0051382)2.49724115
131eyelid development in camera-type eye (GO:0061029)2.48846753
132protein targeting (GO:0006605)2.48835028
133establishment of protein localization to organelle (GO:0072594)2.46067898
134short-term memory (GO:0007614)2.45940064
135mitotic sister chromatid segregation (GO:0000070)2.43755591
136ribonucleoprotein complex assembly (GO:0022618)2.43588762
137polarized epithelial cell differentiation (GO:0030859)2.42174680
138protein localization to kinetochore (GO:0034501)2.40727360
139UTP metabolic process (GO:0046051)2.40296075
140cell migration in hindbrain (GO:0021535)2.39365661
141positive regulation of cellular response to oxidative stress (GO:1900409)2.39107149
142positive regulation of response to oxidative stress (GO:1902884)2.39107149
143ribonucleoprotein complex subunit organization (GO:0071826)2.32857501
144DNA-templated transcription, termination (GO:0006353)2.32339980
145DNA strand elongation involved in DNA replication (GO:0006271)2.30924485
146RNA splicing (GO:0008380)2.30791504
147regulation of protein heterodimerization activity (GO:0043497)2.28401436
148axon ensheathment in central nervous system (GO:0032291)2.28112710
149central nervous system myelination (GO:0022010)2.28112710
150spliceosomal tri-snRNP complex assembly (GO:0000244)2.25532214
151chaperone-mediated protein transport (GO:0072321)2.24968798
152transcription elongation from RNA polymerase I promoter (GO:0006362)2.24501357
153negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.24471433
154DNA replication checkpoint (GO:0000076)2.24324454
155chaperone-mediated protein complex assembly (GO:0051131)2.22371601
156mRNA splice site selection (GO:0006376)2.21918702
157transcription-coupled nucleotide-excision repair (GO:0006283)2.18996878

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* MYC_18555785_ChIP-Seq_MESCs_Mouse4.34134267
2E2F7_22180533_ChIP-Seq_HELA_Human4.09839899
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.94298519
4MYC_19079543_ChIP-ChIP_MESCs_Mouse3.52360111
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.35910162
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.08599288
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.89373738
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.86037844
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.78853825
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.78492100
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.70478797
12KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.68486014
13KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.68486014
14KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.68486014
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.66325230
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.62133287
17XRN2_22483619_ChIP-Seq_HELA_Human2.54518210
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.51454124
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.50145081
20* GABP_17652178_ChIP-ChIP_JURKAT_Human2.42538845
21MYC_18358816_ChIP-ChIP_MESCs_Mouse2.41981458
22CREB1_15753290_ChIP-ChIP_HEK293T_Human2.41220880
23TTF2_22483619_ChIP-Seq_HELA_Human2.36920475
24MYC_22102868_ChIP-Seq_BL_Human2.26835070
25KLF4_19030024_ChIP-ChIP_MESCs_Mouse2.19713669
26STAT6_21828071_ChIP-Seq_BEAS2B_Human2.15091837
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.03419095
28* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.00618659
29TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.95991790
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.84921936
31THAP11_20581084_ChIP-Seq_MESCs_Mouse1.82509391
32DCP1A_22483619_ChIP-Seq_HELA_Human1.81753499
33PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.81313178
34VDR_21846776_ChIP-Seq_THP-1_Human1.80584856
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.79251887
36MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.79016136
37ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.77526217
38RARG_19884340_ChIP-ChIP_MEFs_Mouse1.77370992
39TP63_19390658_ChIP-ChIP_HaCaT_Human1.76707960
40MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.76484712
41ELK3_25401928_ChIP-Seq_HUVEC_Human1.74433202
42ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.73342017
43POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.71249304
44* LXR_22292898_ChIP-Seq_THP-1_Human1.70634414
45SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.68611570
46POU5F1_16153702_ChIP-ChIP_HESCs_Human1.68171707
47* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.66247309
48CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.65907554
49RACK7_27058665_Chip-Seq_MCF-7_Human1.65782528
50* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.65593727
51SOX2_18555785_ChIP-Seq_MESCs_Mouse1.64787731
52POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.64499529
53SOX2_16153702_ChIP-ChIP_HESCs_Human1.61627630
54KLF4_18555785_ChIP-Seq_MESCs_Mouse1.61393967
55NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.57452503
56E2F1_18555785_ChIP-Seq_MESCs_Mouse1.52581883
57ELK1_19687146_ChIP-ChIP_HELA_Human1.48415803
58EGR1_19374776_ChIP-ChIP_THP-1_Human1.45868071
59TCF3_18692474_ChIP-Seq_MEFs_Mouse1.44062734
60CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.42416394
61SRY_22984422_ChIP-ChIP_TESTIS_Rat1.41822230
62TET1_21451524_ChIP-Seq_MESCs_Mouse1.41080974
63VDR_23849224_ChIP-Seq_CD4+_Human1.38529314
64* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.38494822
65CLOCK_20551151_ChIP-Seq_293T_Human1.37114956
66YY1_21170310_ChIP-Seq_MESCs_Mouse1.35128122
67NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.34711150
68KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.32797843
69TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.31077959
70BMI1_23680149_ChIP-Seq_NPCS_Mouse1.30821249
71FOXP3_21729870_ChIP-Seq_TREG_Human1.29990111
72NANOG_18555785_ChIP-Seq_MESCs_Mouse1.29924500
73STAT3_1855785_ChIP-Seq_MESCs_Mouse1.29192871
74POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.28952674
75KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.28072965
76MYC_18940864_ChIP-ChIP_HL60_Human1.27861263
77NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.27534832
78TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.27518915
79NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.26716613
80HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.24952605
81TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.24676271
82KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.24311599
83RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.24190756
84CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.23538762
85ZFP281_18757296_ChIP-ChIP_E14_Mouse1.22698330
86ELK1_22589737_ChIP-Seq_MCF10A_Human1.21927845
87ATF3_27146783_Chip-Seq_COLON_Human1.21116482
88KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.20868647
89RBPJ_22232070_ChIP-Seq_NCS_Mouse1.20695702
90UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.17467229
91EZH2_27304074_Chip-Seq_ESCs_Mouse1.16066822
92OCT4_18692474_ChIP-Seq_MEFs_Mouse1.15788449
93YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.15762886
94TCF3_18692474_ChIP-Seq_MESCs_Mouse1.14867086
95E2F1_21310950_ChIP-Seq_MCF-7_Human1.13185491
96P300_27058665_Chip-Seq_ZR-75-30cells_Human1.12658803
97SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.12569647
98TP53_20018659_ChIP-ChIP_R1E_Mouse1.12140938
99EZH2_22144423_ChIP-Seq_EOC_Human1.10543792
100ERG_21242973_ChIP-ChIP_JURKAT_Human1.10177365
101ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.09238082
102* GABP_19822575_ChIP-Seq_HepG2_Human1.09188631
103THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.08662892
104KDM2B_26808549_Chip-Seq_DND41_Human1.07899282
105PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.07821333
106KDM2B_26808549_Chip-Seq_SUP-B15_Human1.07780472
107HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.07615329
108NANOG_16153702_ChIP-ChIP_HESCs_Human1.07593413
109TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07514743
110SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.07243615
111DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.07055909
112P68_20966046_ChIP-Seq_HELA_Human1.06730956
113SOX2_18692474_ChIP-Seq_MEFs_Mouse1.05979110
114CBX2_27304074_Chip-Seq_ESCs_Mouse1.05169018
115BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04545572
116KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.03671262
117CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.03075373
118NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.02532964
119TP63_17297297_ChIP-ChIP_HaCaT_Human1.02484526
120SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.02402474
121ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.01854658
122CTCF_18555785_ChIP-Seq_MESCs_Mouse1.01213045
123POU5F1_16518401_ChIP-PET_MESCs_Mouse1.00378055
124SA1_27219007_Chip-Seq_ERYTHROID_Human1.00277144
125TBX5_21415370_ChIP-Seq_HL-1_Mouse0.99984246
126CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.99742309
127* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.99475551
128SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.99009573
129CHD1_26751641_Chip-Seq_LNCaP_Human0.98836049
130WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.98553778
131AR_21909140_ChIP-Seq_LNCAP_Human0.98075559
132* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98004960
133NCOR1_26117541_ChIP-Seq_K562_Human0.97739805
134KDM2B_26808549_Chip-Seq_K562_Human0.97649318
135DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.97637949
136NANOG_21062744_ChIP-ChIP_HESCs_Human0.96998424
137ESR1_15608294_ChIP-ChIP_MCF-7_Human0.96529059
138NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.96387233
139MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.95729487
140ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92601007
141CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.91770474
142ZNF263_19887448_ChIP-Seq_K562_Human0.91372294
143PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.91011072
144SOX17_20123909_ChIP-Seq_XEN_Mouse0.90917714
145FOXP1_21924763_ChIP-Seq_HESCs_Human0.90572387
146NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.90190816
147SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.88343672
148WT1_19549856_ChIP-ChIP_CCG9911_Human0.87667939
149KDM5A_27292631_Chip-Seq_BREAST_Human0.87359598
150JARID2_20064375_ChIP-Seq_MESCs_Mouse0.86491760

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.51644742
2MP0009379_abnormal_foot_pigmentation4.16429668
3MP0002877_abnormal_melanocyte_morpholog2.96887687
4MP0010030_abnormal_orbit_morphology2.87098357
5MP0004233_abnormal_muscle_weight2.72539393
6MP0005451_abnormal_body_composition2.66104414
7MP0004957_abnormal_blastocyst_morpholog2.43159045
8MP0004185_abnormal_adipocyte_glucose2.40751544
9MP0008438_abnormal_cutaneous_collagen2.33937775
10MP0008932_abnormal_embryonic_tissue2.16823439
11MP0002653_abnormal_ependyma_morphology2.06112344
12MP0003136_yellow_coat_color2.05864551
13MP0006292_abnormal_olfactory_placode2.05291019
14MP0003693_abnormal_embryo_hatching2.05054753
15MP0000049_abnormal_middle_ear2.01153598
16MP0008789_abnormal_olfactory_epithelium1.99305417
17MP0002102_abnormal_ear_morphology1.95822676
18MP0003111_abnormal_nucleus_morphology1.90633490
19MP0005076_abnormal_cell_differentiation1.85714196
20MP0003941_abnormal_skin_development1.84582014
21MP0005501_abnormal_skin_physiology1.82411674
22MP0002796_impaired_skin_barrier1.82139405
23MP0003123_paternal_imprinting1.82098553
24MP0003938_abnormal_ear_development1.81508631
25MP0002751_abnormal_autonomic_nervous1.81459540
26MP0004858_abnormal_nervous_system1.81202065
27MP0003566_abnormal_cell_adhesion1.80833268
28MP0003385_abnormal_body_wall1.76224850
29MP0003119_abnormal_digestive_system1.75857989
30MP0003937_abnormal_limbs/digits/tail_de1.74964636
31MP0000778_abnormal_nervous_system1.74625248
32MP0009672_abnormal_birth_weight1.74300617
33MP0004133_heterotaxia1.71962977
34MP0010234_abnormal_vibrissa_follicle1.70873711
35MP0001849_ear_inflammation1.69192260
36MP0000537_abnormal_urethra_morphology1.67832978
37MP0005394_taste/olfaction_phenotype1.64200638
38MP0005499_abnormal_olfactory_system1.64200638
39MP0003077_abnormal_cell_cycle1.63727538
40MP0005623_abnormal_meninges_morphology1.62503719
41MP0003890_abnormal_embryonic-extraembry1.62059031
42MP0002938_white_spotting1.60628718
43MP0003880_abnormal_central_pattern1.60192672
44MP0000678_abnormal_parathyroid_gland1.59602176
45MP0006072_abnormal_retinal_apoptosis1.58732979
46MP0002249_abnormal_larynx_morphology1.56906531
47MP0003315_abnormal_perineum_morphology1.56221019
48MP0000751_myopathy1.55462732
49MP0009053_abnormal_anal_canal1.54035704
50MP0001529_abnormal_vocalization1.53937955
51MP0010094_abnormal_chromosome_stability1.52363022
52MP0003122_maternal_imprinting1.52051546
53MP0003861_abnormal_nervous_system1.50549184
54MP0003755_abnormal_palate_morphology1.47816508
55MP0002085_abnormal_embryonic_tissue1.44552050
56MP0000747_muscle_weakness1.42538918
57MP0000579_abnormal_nail_morphology1.41482242
58MP0003121_genomic_imprinting1.41100060
59MP0003453_abnormal_keratinocyte_physiol1.40738888
60MP0009250_abnormal_appendicular_skeleto1.40223631
61MP0000762_abnormal_tongue_morphology1.38019323
62MP0004272_abnormal_basement_membrane1.37027450
63MP0003283_abnormal_digestive_organ1.36201030
64MP0001188_hyperpigmentation1.35211261
65MP0002060_abnormal_skin_morphology1.34981480
66MP0002084_abnormal_developmental_patter1.34695275
67MP0001286_abnormal_eye_development1.32183699
68MP0000759_abnormal_skeletal_muscle1.32031759
69MP0001730_embryonic_growth_arrest1.29896879
70MP0002089_abnormal_postnatal_growth/wei1.29425097
71MP0002282_abnormal_trachea_morphology1.27673591
72MP0003942_abnormal_urinary_system1.25557094
73MP0004270_analgesia1.25198664
74MP0001293_anophthalmia1.24487854
75MP0004145_abnormal_muscle_electrophysio1.21986843
76MP0002697_abnormal_eye_size1.21692820
77MP0004087_abnormal_muscle_fiber1.21539522
78MP0002116_abnormal_craniofacial_bone1.20566936
79MP0000566_synostosis1.20389176
80MP0000428_abnormal_craniofacial_morphol1.18780313
81MP0002233_abnormal_nose_morphology1.17092824
82MP0001697_abnormal_embryo_size1.14394515
83MP0008057_abnormal_DNA_replication1.14063825
84MP0000003_abnormal_adipose_tissue1.12663228
85MP0000350_abnormal_cell_proliferation1.12351373
86MP0002234_abnormal_pharynx_morphology1.11490441
87MP0005666_abnormal_adipose_tissue1.10217804
88MP0000313_abnormal_cell_death1.09379288
89MP0004197_abnormal_fetal_growth/weight/1.08794961
90MP0002184_abnormal_innervation1.08180738
91MP0002163_abnormal_gland_morphology1.07113656
92MP0000462_abnormal_digestive_system1.06112972
93MP0010352_gastrointestinal_tract_polyps1.05777052
94MP0003567_abnormal_fetal_cardiomyocyte1.04987853
95MP0001485_abnormal_pinna_reflex1.04291655
96MP0002932_abnormal_joint_morphology1.03765533
97MP0000631_abnormal_neuroendocrine_gland1.03763192
98MP0002111_abnormal_tail_morphology1.03582521
99MP0005380_embryogenesis_phenotype1.02914037
100MP0001672_abnormal_embryogenesis/_devel1.02914037
101MP0001346_abnormal_lacrimal_gland1.02102252
102MP0002114_abnormal_axial_skeleton1.01736082
103MP0005257_abnormal_intraocular_pressure1.01597969
104MP0000432_abnormal_head_morphology1.01508465
105MP0005375_adipose_tissue_phenotype1.01132395
106MP0000490_abnormal_crypts_of1.01028740
107MP0000749_muscle_degeneration0.99980721
108MP0003935_abnormal_craniofacial_develop0.97761197
109MP0000467_abnormal_esophagus_morphology0.97416425
110MP0000955_abnormal_spinal_cord0.97135601
111MP0002086_abnormal_extraembryonic_tissu0.97105744
112MP0002081_perinatal_lethality0.95925691
113MP0002269_muscular_atrophy0.95652803
114MP0000534_abnormal_ureter_morphology0.95211399
115MP0002752_abnormal_somatic_nervous0.94560512
116MP0002152_abnormal_brain_morphology0.93366291
117MP0010630_abnormal_cardiac_muscle0.93245197
118MP0003950_abnormal_plasma_membrane0.92964426
119MP0005058_abnormal_lysosome_morphology0.92618359
120MP0001727_abnormal_embryo_implantation0.91604621
121MP0002080_prenatal_lethality0.90015687
122MP0000358_abnormal_cell_content/0.89396877
123MP0001340_abnormal_eyelid_morphology0.89165817
124MP0002177_abnormal_outer_ear0.88230396
125MP0002837_dystrophic_cardiac_calcinosis0.87465858
126MP0001216_abnormal_epidermal_layer0.87407298
127MP0000750_abnormal_muscle_regeneration0.87196181
128MP0000858_altered_metastatic_potential0.87093165
129MP0000026_abnormal_inner_ear0.87045391
130MP0006276_abnormal_autonomic_nervous0.86586502
131MP0008007_abnormal_cellular_replicative0.85550225
132MP0005409_darkened_coat_color0.83696845
133MP0003786_premature_aging0.83501851
134MP0002092_abnormal_eye_morphology0.82613289
135MP0009278_abnormal_bone_marrow0.82270691
136MP0005621_abnormal_cell_physiology0.81182652
137MP0001348_abnormal_lacrimal_gland0.81156998
138MP0005023_abnormal_wound_healing0.80862643
139MP0008995_early_reproductive_senescence0.80529176
140MP0008058_abnormal_DNA_repair0.80227985
141MP0004808_abnormal_hematopoietic_stem0.80100760
142MP0008877_abnormal_DNA_methylation0.79983983
143MP0001881_abnormal_mammary_gland0.79560953
144MP0000733_abnormal_muscle_development0.79141216
145MP0008260_abnormal_autophagy0.78814709
146MP0002088_abnormal_embryonic_growth/wei0.77597799
147MP0003115_abnormal_respiratory_system0.77469428
148MP0003984_embryonic_growth_retardation0.76918356
149MP0005384_cellular_phenotype0.76827820
150MP0000627_abnormal_mammary_gland0.75606032
151MP0010771_integument_phenotype0.74823341
152MP0003091_abnormal_cell_migration0.74215026
153MP0003806_abnormal_nucleotide_metabolis0.73903286
154MP0001299_abnormal_eye_distance/0.72996085
155MP0005330_cardiomyopathy0.72639187
156MP0005503_abnormal_tendon_morphology0.70395721

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.92951498
2Abnormality of cells of the erythroid lineage (HP:0012130)4.33299970
3Hyperacusis (HP:0010780)4.21854498
4Macrocytic anemia (HP:0001972)4.05914279
5Premature rupture of membranes (HP:0001788)3.60824550
6Insomnia (HP:0100785)3.46748426
7Progressive muscle weakness (HP:0003323)3.40338292
8Protrusio acetabuli (HP:0003179)3.38817275
9Achilles tendon contracture (HP:0001771)3.38302584
10Pallor (HP:0000980)3.27584918
11Centrally nucleated skeletal muscle fibers (HP:0003687)3.24180013
12Abnormal number of erythroid precursors (HP:0012131)3.22981601
13Acute necrotizing encephalopathy (HP:0006965)3.14804786
14Distal lower limb amyotrophy (HP:0008944)3.14137792
15Overriding aorta (HP:0002623)2.99700339
16Concave nail (HP:0001598)2.98863852
17Distal lower limb muscle weakness (HP:0009053)2.97811712
18Increased connective tissue (HP:0009025)2.92311509
19Spinal rigidity (HP:0003306)2.91082465
20Abnormality of the Achilles tendon (HP:0005109)2.90643484
21Absent radius (HP:0003974)2.80539962
22Abnormal hemoglobin (HP:0011902)2.75468429
23Back pain (HP:0003418)2.68695019
24Myopathic facies (HP:0002058)2.68678342
25Aplasia involving forearm bones (HP:0009822)2.67953817
26Absent forearm bone (HP:0003953)2.67953817
27Elfin facies (HP:0004428)2.65933942
28Abnormal number of incisors (HP:0011064)2.65213944
29Increased hepatocellular lipid droplets (HP:0006565)2.63811944
30Renal duplication (HP:0000075)2.60575691
31Nemaline bodies (HP:0003798)2.55222097
32Ulnar bowing (HP:0003031)2.55076370
33Rib fusion (HP:0000902)2.54488498
34Horseshoe kidney (HP:0000085)2.52294943
35Calcaneovalgus deformity (HP:0001848)2.49529834
36Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.44851248
37Mitochondrial inheritance (HP:0001427)2.44481600
38Progressive macrocephaly (HP:0004481)2.44184737
39Multiple enchondromatosis (HP:0005701)2.41668605
40Vertebral compression fractures (HP:0002953)2.41303889
41Type 1 muscle fiber predominance (HP:0003803)2.40485080
42Abnormal mitochondria in muscle tissue (HP:0008316)2.39367281
43Abnormality of the labia minora (HP:0012880)2.36807166
44Muscle fiber inclusion bodies (HP:0100299)2.36485243
45Chin dimple (HP:0010751)2.34424362
46Lower limb amyotrophy (HP:0007210)2.29951452
47Bladder diverticulum (HP:0000015)2.27912231
48Fragile skin (HP:0001030)2.26678006
49Abnormality of skeletal muscle fiber size (HP:0012084)2.24783207
50Shallow orbits (HP:0000586)2.24769256
51Aplasia/Hypoplasia of the sacrum (HP:0008517)2.24269773
52Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.22218376
53Facial hemangioma (HP:0000329)2.21815641
54Esophageal atresia (HP:0002032)2.21006047
55Breast hypoplasia (HP:0003187)2.19911905
56Patellar dislocation (HP:0002999)2.19139524
57Ankle contracture (HP:0006466)2.18710703
58Short nail (HP:0001799)2.18590918
59Abnormal gallbladder physiology (HP:0012438)2.14631989
60Cholecystitis (HP:0001082)2.14631989
61Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.14585220
62Cerebral hypomyelination (HP:0006808)2.14268669
63Abnormality of the calcaneus (HP:0008364)2.13167811
64Anophthalmia (HP:0000528)2.12669360
65Atresia of the external auditory canal (HP:0000413)2.12340828
66Increased nuchal translucency (HP:0010880)2.12318430
67Patellar aplasia (HP:0006443)2.11683482
68Triphalangeal thumb (HP:0001199)2.11241792
69Abnormality of dentin (HP:0010299)2.10948105
70Acute encephalopathy (HP:0006846)2.10840051
71Aplasia/Hypoplasia of the patella (HP:0006498)2.10638223
72Abnormality of abdominal situs (HP:0011620)2.09314769
73Abdominal situs inversus (HP:0003363)2.09314769
74Deformed tarsal bones (HP:0008119)2.09221109
75Rough bone trabeculation (HP:0100670)2.08302452
76Asymmetry of the thorax (HP:0001555)2.07555361
77Sensory axonal neuropathy (HP:0003390)2.06974443
78Lipid accumulation in hepatocytes (HP:0006561)2.05943323
79Generalized amyotrophy (HP:0003700)2.04752947
80Difficulty climbing stairs (HP:0003551)2.04193470
81Flat cornea (HP:0007720)2.02875845
82Long palpebral fissure (HP:0000637)2.02794526
83Distal upper limb amyotrophy (HP:0007149)2.02746635
84Upper limb amyotrophy (HP:0009129)2.02746635
85Breech presentation (HP:0001623)2.02301271
86Absent thumb (HP:0009777)2.01472652
87Overfolded helix (HP:0000396)2.00930303
88Disproportionate tall stature (HP:0001519)1.99084846
89Supernumerary bones of the axial skeleton (HP:0009144)1.98465600
90Aplasia cutis congenita (HP:0001057)1.95786945
91Renovascular hypertension (HP:0100817)1.93219146
92Spinal cord compression (HP:0002176)1.92771292
93Trismus (HP:0000211)1.92178519
94Elbow flexion contracture (HP:0002987)1.91652250
95Reticulocytosis (HP:0001923)1.91229702
96Supernumerary spleens (HP:0009799)1.91220425
97Progressive external ophthalmoplegia (HP:0000590)1.91089430
98Supernumerary ribs (HP:0005815)1.90995252
99Duplication of thumb phalanx (HP:0009942)1.90319356
100Partial duplication of the phalanx of hand (HP:0009999)1.90185075
101Leukodystrophy (HP:0002415)1.89948595
102Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.89376545
103Genu recurvatum (HP:0002816)1.88977210
104Abnormality of the umbilical cord (HP:0010881)1.88444036
105Down-sloping shoulders (HP:0200021)1.87991068
106Increased variability in muscle fiber diameter (HP:0003557)1.87757424
107Ragged-red muscle fibers (HP:0003200)1.87600486
108Fused cervical vertebrae (HP:0002949)1.87156106
109Abnormality of the tricuspid valve (HP:0001702)1.86873321
110Stenosis of the external auditory canal (HP:0000402)1.84929563
111Muscle stiffness (HP:0003552)1.84175472
112Renal Fanconi syndrome (HP:0001994)1.83919446
113Orthostatic hypotension (HP:0001278)1.83360340
114Coronal craniosynostosis (HP:0004440)1.83133978
115Hypercalcemia (HP:0003072)1.82417070
116Adducted thumb (HP:0001181)1.82112694
117Mildly elevated creatine phosphokinase (HP:0008180)1.81813961
118Abnormally folded helix (HP:0008544)1.81456329
119Shoulder girdle muscle weakness (HP:0003547)1.80886441
120Abnormal sex determination (HP:0012244)1.80422456
121Sex reversal (HP:0012245)1.80422456
122Septo-optic dysplasia (HP:0100842)1.80328123
123Microvesicular hepatic steatosis (HP:0001414)1.80086492
124Turricephaly (HP:0000262)1.79034977
125Broad distal phalanx of finger (HP:0009836)1.79007191
126Morphological abnormality of the middle ear (HP:0008609)1.78232564
127Increased CSF lactate (HP:0002490)1.77246336
128Optic disc pallor (HP:0000543)1.75899666
129Hyperparathyroidism (HP:0000843)1.74765893
130Depressed nasal ridge (HP:0000457)1.74492387
131Deviation of the thumb (HP:0009603)1.73948390
132Selective tooth agenesis (HP:0001592)1.73171290
133Mitral regurgitation (HP:0001653)1.72953752
134Duplicated collecting system (HP:0000081)1.72933140
135Hypoplastic pelvis (HP:0008839)1.72593742
136Myelomeningocele (HP:0002475)1.72098155
137Round ear (HP:0100830)1.71382391
138Hydroureter (HP:0000072)1.71181293
139Testicular atrophy (HP:0000029)1.71142119
140Pseudobulbar signs (HP:0002200)1.70751236
141Limb-girdle muscle atrophy (HP:0003797)1.70528868
142Congenital malformation of the right heart (HP:0011723)1.70470213
143Double outlet right ventricle (HP:0001719)1.70470213
144High anterior hairline (HP:0009890)1.70319783
145Congenital hip dislocation (HP:0001374)1.69982996
146Fibular aplasia (HP:0002990)1.69576349
147Ankyloglossia (HP:0010296)1.69487374
148Upper limb muscle weakness (HP:0003484)1.68906129
149Cortical dysplasia (HP:0002539)1.67826870
150Biconcave vertebral bodies (HP:0004586)1.67407533
151Bowel diverticulosis (HP:0005222)1.66965856
152Alacrima (HP:0000522)1.66623797
153Aplasia/hypoplasia of the humerus (HP:0006507)1.65870413
154Parakeratosis (HP:0001036)1.65567413
155Truncus arteriosus (HP:0001660)1.65453214
156Nasolacrimal duct obstruction (HP:0000579)1.65323737
157Facial cleft (HP:0002006)1.65202393
158Abnormality of the antihelix (HP:0009738)1.65187719
159Entropion (HP:0000621)1.64460048
160Delayed cranial suture closure (HP:0000270)1.64425778
161Overlapping toe (HP:0001845)1.64273232
162Osteolytic defects of the phalanges of the hand (HP:0009771)1.63631468
163Osteolytic defects of the hand bones (HP:0009699)1.63631468
164Arnold-Chiari malformation (HP:0002308)1.63076564
165Renal agenesis (HP:0000104)1.62798505
166Thick lower lip vermilion (HP:0000179)1.62365574
167Glossoptosis (HP:0000162)1.62191248
168Partial duplication of thumb phalanx (HP:0009944)1.61940277
169Proximal placement of thumb (HP:0009623)1.61392544
170Metatarsus adductus (HP:0001840)1.61384902
171Abnormality of reticulocytes (HP:0004312)1.61298504
172Exertional dyspnea (HP:0002875)1.61216859
173Maternal diabetes (HP:0009800)1.60904773
174Missing ribs (HP:0000921)1.60299847
175Blue sclerae (HP:0000592)1.60253920
176Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.60232422
177Abnormality of the nasolacrimal system (HP:0000614)1.59852745
178Woolly hair (HP:0002224)1.58966882
179Carpal bone hypoplasia (HP:0001498)1.58944703
180Atelectasis (HP:0100750)1.58626866
181Bilateral microphthalmos (HP:0007633)1.58230739
182Fragile nails (HP:0001808)1.58199006
183Hypoplasia of the radius (HP:0002984)1.57755403
184Abnormality of the lacrimal duct (HP:0011481)1.56985359
185Abnormality of glycolysis (HP:0004366)1.56628845

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK14.54786589
2TRIB34.46833297
3PNCK3.83997239
4BUB13.02301331
5VRK23.00769071
6CDC72.98107681
7SMG12.94652397
8SRPK12.49873193
9IRAK32.42098509
10NME22.30900877
11MKNK12.17354506
12MKNK22.14533100
13WEE12.09036943
14UHMK12.06499763
15LATS22.02602730
16SIK11.97551248
17TESK21.89561912
18NME11.85809435
19TTN1.82641595
20PRPF4B1.78803734
21LIMK11.71984409
22MARK11.52131438
23DYRK21.51336642
24CDK121.50316705
25ARAF1.44219886
26NTRK11.43970428
27EPHB21.41547613
28TAOK21.40500567
29FGR1.38124392
30TTK1.36665519
31PKN21.35235388
32CDK71.34678778
33AURKA1.33332949
34ICK1.30068302
35RPS6KB21.28507290
36EPHA21.27918106
37ERN11.22383538
38ILK1.22259816
39MST1R1.21946071
40CASK1.21928398
41MAP3K101.20849506
42PLK11.20374741
43PASK1.17926634
44STK161.12556126
45RIPK11.12363108
46PTK21.10574849
47PBK1.10336747
48* CSNK1E1.09419646
49PLK31.07873915
50NEK21.05072388
51AURKB1.03741266
52STK391.02818613
53TSSK61.02367518
54PLK41.01964093
55ALK1.01523080
56ROCK21.00597584
57CDK41.00019941
58DAPK30.99751887
59CHEK10.98308165
60EIF2AK10.98124911
61PRKCI0.97480068
62DDR20.96619003
63DYRK30.94975417
64SCYL20.94721938
65CDK140.90635906
66PAK10.90551781
67GRK50.88748641
68CHEK20.87874977
69CSNK2A20.87752253
70MAP3K90.86836900
71TYRO30.86700259
72VRK10.85242245
73STK100.84561169
74MOS0.84054035
75BCR0.84033081
76CDK11A0.83418601
77PLK20.83237212
78MAP2K20.82974701
79PAK20.80996852
80CSNK1G30.79713331
81BRD40.79152164
82MET0.78908384
83PTK60.78452576
84CDK80.78223135
85CDK150.76641994
86MAP3K80.76271013
87TESK10.72423585
88ERBB40.72335370
89TAF10.70979045
90WNK40.70963534
91PAK40.70875102
92FGFR40.69841398
93MAP3K110.69795869
94CDK180.69795018
95ADRBK10.69467244
96CDK20.69450512
97PIM20.68285356
98PKN10.66737718
99KSR20.66699520
100LRRK20.66315114
101RPS6KA50.66094291
102DMPK0.64677647
103CDK10.64527479
104AKT20.64233343
105CAMK2B0.63821634
106CLK10.63345674
107MAPKAPK30.62809816
108STK40.61084021
109ATM0.61008523
110CSNK2A10.59788685
111BMX0.57419369
112DYRK1B0.57211063
113NEK10.56503704
114BRSK10.56243957
115GRK60.55681286
116CSNK1G10.55595162
117CSNK1A1L0.54604779
118LMTK20.52850769
119PAK30.52137209
120SIK20.52071157
121MAP3K130.51700627
122ABL20.51534990
123CSNK1D0.51107092
124CDK190.49905231
125PRKDC0.49900232
126MAPK130.47891556
127PAK60.47881328
128EEF2K0.47735982
129PHKG20.46703228
130PHKG10.46703228
131CAMK1G0.46693997
132BRAF0.46363869
133ATR0.46249290
134PDGFRA0.45947396
135NTRK30.45868841
136DYRK1A0.45798221
137PRKG20.45662272
138EPHA40.45427429
139CDC42BPA0.44248392
140MTOR0.44228076
141GRK70.44048926
142RPS6KA40.43124894
143PRKD30.42686553
144KSR10.40911177
145CDK90.40702190
146MAP2K30.40697593

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.09931728
2Oxidative phosphorylation_Homo sapiens_hsa001903.64024465
3Spliceosome_Homo sapiens_hsa030403.45897829
4Parkinsons disease_Homo sapiens_hsa050123.21543049
5RNA polymerase_Homo sapiens_hsa030203.03487260
6Huntingtons disease_Homo sapiens_hsa050162.70972488
7Proteasome_Homo sapiens_hsa030502.70028577
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.57043085
9Alzheimers disease_Homo sapiens_hsa050102.55786761
10Mismatch repair_Homo sapiens_hsa034302.53628429
11RNA transport_Homo sapiens_hsa030132.49686268
12DNA replication_Homo sapiens_hsa030302.44370726
13Biosynthesis of amino acids_Homo sapiens_hsa012302.14755359
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.13124482
15Nucleotide excision repair_Homo sapiens_hsa034202.07047102
16Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.06612263
17Pentose phosphate pathway_Homo sapiens_hsa000301.87832777
18mRNA surveillance pathway_Homo sapiens_hsa030151.85352059
19Cardiac muscle contraction_Homo sapiens_hsa042601.84808590
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.77697657
21Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.77272276
22One carbon pool by folate_Homo sapiens_hsa006701.77120877
23Homologous recombination_Homo sapiens_hsa034401.71132614
24Central carbon metabolism in cancer_Homo sapiens_hsa052301.60151579
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.57104156
26Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.57044657
27Basal cell carcinoma_Homo sapiens_hsa052171.55252189
28Fructose and mannose metabolism_Homo sapiens_hsa000511.54817025
29Hedgehog signaling pathway_Homo sapiens_hsa043401.53061693
30Pyrimidine metabolism_Homo sapiens_hsa002401.52254336
31Carbon metabolism_Homo sapiens_hsa012001.51592028
32Cell cycle_Homo sapiens_hsa041101.51532873
33Protein export_Homo sapiens_hsa030601.49240740
34Fanconi anemia pathway_Homo sapiens_hsa034601.46401974
35Basal transcription factors_Homo sapiens_hsa030221.42495785
36Chronic myeloid leukemia_Homo sapiens_hsa052201.37612739
37Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.37339280
38RNA degradation_Homo sapiens_hsa030181.29409718
39Systemic lupus erythematosus_Homo sapiens_hsa053221.28066493
40Folate biosynthesis_Homo sapiens_hsa007901.16436793
41Galactose metabolism_Homo sapiens_hsa000521.15019137
42Axon guidance_Homo sapiens_hsa043601.10895941
43Prion diseases_Homo sapiens_hsa050201.10153743
44Base excision repair_Homo sapiens_hsa034101.08336804
45Alcoholism_Homo sapiens_hsa050341.06913964
46Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.03897043
47Pyruvate metabolism_Homo sapiens_hsa006201.03106582
48Hippo signaling pathway_Homo sapiens_hsa043901.02015886
49Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.01924996
50Oocyte meiosis_Homo sapiens_hsa041141.00283909
51Wnt signaling pathway_Homo sapiens_hsa043100.98501841
52Bladder cancer_Homo sapiens_hsa052190.95987127
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.90740830
54Pancreatic cancer_Homo sapiens_hsa052120.90098660
55Endometrial cancer_Homo sapiens_hsa052130.88134903
56Melanogenesis_Homo sapiens_hsa049160.87918998
57Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.87579492
58Non-small cell lung cancer_Homo sapiens_hsa052230.87497494
59Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.87170317
60Acute myeloid leukemia_Homo sapiens_hsa052210.87098384
61Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.86995044
62Small cell lung cancer_Homo sapiens_hsa052220.83308182
63Tight junction_Homo sapiens_hsa045300.82622920
64VEGF signaling pathway_Homo sapiens_hsa043700.80166521
65Insulin signaling pathway_Homo sapiens_hsa049100.78997311
66Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.76589003
67MicroRNAs in cancer_Homo sapiens_hsa052060.76288814
68Non-homologous end-joining_Homo sapiens_hsa034500.75397261
69Phototransduction_Homo sapiens_hsa047440.74063616
70N-Glycan biosynthesis_Homo sapiens_hsa005100.72699564
71Sulfur relay system_Homo sapiens_hsa041220.71800601
72Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.71761439
73Long-term depression_Homo sapiens_hsa047300.70998698
74Cysteine and methionine metabolism_Homo sapiens_hsa002700.70548679
75p53 signaling pathway_Homo sapiens_hsa041150.70423264
76Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.70166843
77Gap junction_Homo sapiens_hsa045400.69693635
78Notch signaling pathway_Homo sapiens_hsa043300.69461915
79Focal adhesion_Homo sapiens_hsa045100.68687630
80Shigellosis_Homo sapiens_hsa051310.68481538
81Vitamin B6 metabolism_Homo sapiens_hsa007500.67796187
82Purine metabolism_Homo sapiens_hsa002300.66745173
83Serotonergic synapse_Homo sapiens_hsa047260.65159196
84Lysine degradation_Homo sapiens_hsa003100.64736963
85Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62802712
86Epstein-Barr virus infection_Homo sapiens_hsa051690.62012127
87Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.62001593
88Cyanoamino acid metabolism_Homo sapiens_hsa004600.61319809
89TGF-beta signaling pathway_Homo sapiens_hsa043500.61311258
90Melanoma_Homo sapiens_hsa052180.60951222
91Renal cell carcinoma_Homo sapiens_hsa052110.59213163
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59181226
93AMPK signaling pathway_Homo sapiens_hsa041520.59162081
94Nicotine addiction_Homo sapiens_hsa050330.58619917
95Apoptosis_Homo sapiens_hsa042100.54524654
96Viral carcinogenesis_Homo sapiens_hsa052030.52622931
97Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51713908
98Long-term potentiation_Homo sapiens_hsa047200.51672646
99Steroid biosynthesis_Homo sapiens_hsa001000.48961936
100Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48474366
101Neurotrophin signaling pathway_Homo sapiens_hsa047220.48441979
102Arginine biosynthesis_Homo sapiens_hsa002200.46206544
103Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.45927948
104Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45278302
105Pathways in cancer_Homo sapiens_hsa052000.45224897
106Dopaminergic synapse_Homo sapiens_hsa047280.45050446
107Other glycan degradation_Homo sapiens_hsa005110.45031405
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44150113
109HIF-1 signaling pathway_Homo sapiens_hsa040660.43900371
110Taste transduction_Homo sapiens_hsa047420.42190589
111Thyroid cancer_Homo sapiens_hsa052160.41161848
112Vibrio cholerae infection_Homo sapiens_hsa051100.38874252
113Collecting duct acid secretion_Homo sapiens_hsa049660.38829543
114Glioma_Homo sapiens_hsa052140.37469663
115Estrogen signaling pathway_Homo sapiens_hsa049150.36666818
116Adherens junction_Homo sapiens_hsa045200.34597576
117Linoleic acid metabolism_Homo sapiens_hsa005910.34412485
118Glutamatergic synapse_Homo sapiens_hsa047240.34121223
119HTLV-I infection_Homo sapiens_hsa051660.33688139
120Arginine and proline metabolism_Homo sapiens_hsa003300.32665925
121Ether lipid metabolism_Homo sapiens_hsa005650.32355619
122Prostate cancer_Homo sapiens_hsa052150.31823213
123Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.30494581
124Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.28779958
125Maturity onset diabetes of the young_Homo sapiens_hsa049500.27887120
126PI3K-Akt signaling pathway_Homo sapiens_hsa041510.26485017
127Amphetamine addiction_Homo sapiens_hsa050310.25631095
128Regulation of actin cytoskeleton_Homo sapiens_hsa048100.25258705
129Dilated cardiomyopathy_Homo sapiens_hsa054140.25005870
130Glutathione metabolism_Homo sapiens_hsa004800.24991264
131Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.24708234
132Ras signaling pathway_Homo sapiens_hsa040140.24474143
133GnRH signaling pathway_Homo sapiens_hsa049120.23650045
134ECM-receptor interaction_Homo sapiens_hsa045120.23219956
135Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.22907807
136Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.22543183
137ErbB signaling pathway_Homo sapiens_hsa040120.21401728
138Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.20668860
139Colorectal cancer_Homo sapiens_hsa052100.20111489
140Cocaine addiction_Homo sapiens_hsa050300.18580543
141Metabolic pathways_Homo sapiens_hsa011000.17882014
142Proteoglycans in cancer_Homo sapiens_hsa052050.17432665
143Rap1 signaling pathway_Homo sapiens_hsa040150.16995721
144Cholinergic synapse_Homo sapiens_hsa047250.13834876

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