PCYT2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme that catalyzes the formation of CDP-ethanolamine from CTP and phosphoethanolamine in the Kennedy pathway of phospholipid synthesis. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.62005001
2L-phenylalanine catabolic process (GO:0006559)7.62005001
3L-phenylalanine metabolic process (GO:0006558)7.28468166
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.28468166
5aromatic amino acid family catabolic process (GO:0009074)6.50543617
6glyoxylate metabolic process (GO:0046487)5.83542039
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.82304483
8indole-containing compound catabolic process (GO:0042436)5.61445090
9indolalkylamine catabolic process (GO:0046218)5.61445090
10tryptophan catabolic process (GO:0006569)5.61445090
11bile acid biosynthetic process (GO:0006699)5.54989557
12kynurenine metabolic process (GO:0070189)5.46574728
13alpha-linolenic acid metabolic process (GO:0036109)5.39070288
14sulfur amino acid catabolic process (GO:0000098)5.33225996
15proline metabolic process (GO:0006560)5.31226486
16tryptophan metabolic process (GO:0006568)5.23871462
17cysteine metabolic process (GO:0006534)5.19519823
18proline biosynthetic process (GO:0006561)5.17738873
19high-density lipoprotein particle remodeling (GO:0034375)5.02920744
20urea cycle (GO:0000050)4.89952516
21urea metabolic process (GO:0019627)4.89952516
22bile acid metabolic process (GO:0008206)4.87407918
23negative regulation of fibrinolysis (GO:0051918)4.77125820
24aromatic amino acid family metabolic process (GO:0009072)4.73924476
25serine family amino acid catabolic process (GO:0009071)4.71808270
26regulation of cholesterol biosynthetic process (GO:0045540)4.71737845
27nitrogen cycle metabolic process (GO:0071941)4.65840434
28protein carboxylation (GO:0018214)4.63755729
29peptidyl-glutamic acid carboxylation (GO:0017187)4.63755729
30regulation of fibrinolysis (GO:0051917)4.63022070
31regulation of cholesterol esterification (GO:0010872)4.54748479
32regulation of protein activation cascade (GO:2000257)4.51640355
33fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.49605038
34complement activation, alternative pathway (GO:0006957)4.48555421
35coenzyme catabolic process (GO:0009109)4.48044660
36tyrosine metabolic process (GO:0006570)4.47933685
37triglyceride homeostasis (GO:0070328)4.46153819
38acylglycerol homeostasis (GO:0055090)4.46153819
39regulation of triglyceride catabolic process (GO:0010896)4.45503259
40alpha-amino acid catabolic process (GO:1901606)4.39933535
41cellular ketone body metabolic process (GO:0046950)4.35914665
42reverse cholesterol transport (GO:0043691)4.33677255
43heme transport (GO:0015886)4.27394364
44plasma lipoprotein particle remodeling (GO:0034369)4.26452146
45protein-lipid complex remodeling (GO:0034368)4.26452146
46macromolecular complex remodeling (GO:0034367)4.26452146
47acetyl-CoA metabolic process (GO:0006084)4.26444676
48cholesterol efflux (GO:0033344)4.23350142
49negative regulation of cholesterol transport (GO:0032375)4.22913170
50negative regulation of sterol transport (GO:0032372)4.22913170
51serine family amino acid biosynthetic process (GO:0009070)4.22040262
52very-low-density lipoprotein particle assembly (GO:0034379)4.21458165
53regulation of plasminogen activation (GO:0010755)4.19760234
54homocysteine metabolic process (GO:0050667)4.18575615
55plasma lipoprotein particle clearance (GO:0034381)4.18365187
56regulation of complement activation (GO:0030449)4.16605026
57serine family amino acid metabolic process (GO:0009069)4.15290397
58cellular amino acid catabolic process (GO:0009063)4.12121096
59phospholipid efflux (GO:0033700)4.12115341
60fatty acid elongation (GO:0030497)4.11121793
61amino-acid betaine metabolic process (GO:0006577)4.10172206
62ethanol oxidation (GO:0006069)4.09954471
63glycine metabolic process (GO:0006544)4.09467610
64glutamate metabolic process (GO:0006536)4.08173584
65lysine metabolic process (GO:0006553)4.05628491
66lysine catabolic process (GO:0006554)4.05628491
67amine catabolic process (GO:0009310)4.04002914
68cellular biogenic amine catabolic process (GO:0042402)4.04002914
69indolalkylamine metabolic process (GO:0006586)4.01641954
70NADH metabolic process (GO:0006734)4.00999826
71glutamine family amino acid biosynthetic process (GO:0009084)4.00322725
72plasma lipoprotein particle assembly (GO:0034377)3.96615841
73regulation of cholesterol homeostasis (GO:2000188)3.93879846
74low-density lipoprotein particle clearance (GO:0034383)3.90592716
75bile acid and bile salt transport (GO:0015721)3.87665295
76imidazole-containing compound metabolic process (GO:0052803)3.87142541
77regulation of apoptotic cell clearance (GO:2000425)3.86716776
78intestinal cholesterol absorption (GO:0030299)3.86169144
79positive regulation of triglyceride lipase activity (GO:0061365)3.86103051
80positive regulation of lipoprotein lipase activity (GO:0051006)3.86103051
81regulation of bile acid biosynthetic process (GO:0070857)3.84937209
82short-chain fatty acid metabolic process (GO:0046459)3.82901060
83cofactor catabolic process (GO:0051187)3.82862007
84aldehyde catabolic process (GO:0046185)3.82159473
85cellular modified amino acid catabolic process (GO:0042219)3.82155174
86very long-chain fatty acid metabolic process (GO:0000038)3.82096145
87Golgi transport vesicle coating (GO:0048200)3.81022068
88COPI coating of Golgi vesicle (GO:0048205)3.81022068
89ethanol metabolic process (GO:0006067)3.80785986
90ketone body metabolic process (GO:1902224)3.79186840
91drug catabolic process (GO:0042737)3.75667637
92cellular glucuronidation (GO:0052695)3.75635991
93cholesterol homeostasis (GO:0042632)3.72982999
94L-serine metabolic process (GO:0006563)3.72445363
95benzene-containing compound metabolic process (GO:0042537)3.70687622
96protein-lipid complex assembly (GO:0065005)3.67938583
97cholesterol biosynthetic process (GO:0006695)3.66520215
98sterol homeostasis (GO:0055092)3.65812894
99carboxylic acid catabolic process (GO:0046395)3.64401724
100organic acid catabolic process (GO:0016054)3.64401724
101protein-lipid complex subunit organization (GO:0071825)3.58330911
102arginine metabolic process (GO:0006525)3.58056009
103regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.55495686
104fatty-acyl-CoA biosynthetic process (GO:0046949)3.55271698
105low-density lipoprotein particle remodeling (GO:0034374)3.54080654
106positive regulation of fatty acid biosynthetic process (GO:0045723)3.52549653
107aspartate family amino acid catabolic process (GO:0009068)3.49431105
108oxaloacetate metabolic process (GO:0006107)3.49064106
109regulation of cholesterol metabolic process (GO:0090181)3.47358432
110negative regulation of fatty acid biosynthetic process (GO:0045717)3.46835991
111dicarboxylic acid biosynthetic process (GO:0043650)3.45384294
112blood coagulation, intrinsic pathway (GO:0007597)3.42702491
113plasma lipoprotein particle organization (GO:0071827)3.41614365
114cytolysis (GO:0019835)3.40570365
115NAD biosynthetic process (GO:0009435)3.40534637
116fibrinolysis (GO:0042730)3.39519752
117epoxygenase P450 pathway (GO:0019373)3.39246810
118diacylglycerol metabolic process (GO:0046339)3.36224403
119intestinal absorption (GO:0050892)3.32270832
120retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.27326429
121protein retention in ER lumen (GO:0006621)3.25146146
122tricarboxylic acid metabolic process (GO:0072350)3.22100434
123positive regulation of extracellular matrix organization (GO:1903055)3.19363595
124regulation of fatty acid biosynthetic process (GO:0042304)3.14594824
1254-hydroxyproline metabolic process (GO:0019471)3.10077034
126maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.09043955
127negative regulation of lipid transport (GO:0032369)3.08690127
128glucose 6-phosphate metabolic process (GO:0051156)2.96685897
129basement membrane organization (GO:0071711)2.96678961
130negative regulation of lipase activity (GO:0060192)2.95773447
131neutral lipid catabolic process (GO:0046461)2.95464019
132acylglycerol catabolic process (GO:0046464)2.95464019
133fatty acid homeostasis (GO:0055089)2.94683605
134negative regulation of blood coagulation (GO:0030195)2.94298676
135negative regulation of hemostasis (GO:1900047)2.94298676
136acute-phase response (GO:0006953)2.91828013
137lipoprotein metabolic process (GO:0042157)2.86161437
138positive regulation of steroid metabolic process (GO:0045940)2.85817522
139positive regulation of lipid catabolic process (GO:0050996)2.84877061
140positive regulation of cellular amine metabolic process (GO:0033240)2.84401590
141monosaccharide biosynthetic process (GO:0046364)2.74865714
142primary alcohol catabolic process (GO:0034310)2.74434207
143gluconeogenesis (GO:0006094)2.72671812
144regulation of extracellular matrix organization (GO:1903053)2.68429332
145renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.67084997
146lung epithelium development (GO:0060428)2.67052983
147positive regulation of blood coagulation (GO:0030194)2.67014912
148positive regulation of hemostasis (GO:1900048)2.67014912
149hexose biosynthetic process (GO:0019319)2.66956818
150sexual reproduction (GO:0019953)2.65628138

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.85658567
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.61986492
3LXR_22158963_ChIP-Seq_LIVER_Mouse6.06623797
4EGR1_23403033_ChIP-Seq_LIVER_Mouse6.03263246
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.24548156
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.74289112
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.43316907
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.01519888
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.78449603
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.09870356
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.57337139
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.44540477
13TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.09019423
14ELK3_25401928_ChIP-Seq_HUVEC_Human2.00479981
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.8153285
16TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.98931242
17VDR_21846776_ChIP-Seq_THP-1_Human1.88893796
18EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.81124324
19EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.76273831
20TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72282341
21KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.69892586
22MYC_22102868_ChIP-Seq_BL_Human1.69483710
23MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.67231133
24SMC4_20622854_ChIP-Seq_HELA_Human1.63586738
25HTT_18923047_ChIP-ChIP_STHdh_Human1.60642773
26KDM2B_26808549_Chip-Seq_SUP-B15_Human1.59992431
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.58831249
28DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.54008836
29HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.53400867
30ELF1_20517297_ChIP-Seq_JURKAT_Human1.48138989
31FOXA2_19822575_ChIP-Seq_HepG2_Human1.46999613
32* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.46801571
33UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.45802188
34TCF7_22412390_ChIP-Seq_EML_Mouse1.45615178
35ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.44647334
36SRY_22984422_ChIP-ChIP_TESTIS_Rat1.43158619
37* SA1_27219007_Chip-Seq_ERYTHROID_Human1.41133233
38THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.40659047
39KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.39615348
40KDM2B_26808549_Chip-Seq_K562_Human1.37857743
41* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.35910150
42* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.35706622
43* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.34887276
44ZFP281_18757296_ChIP-ChIP_E14_Mouse1.33394233
45CREB1_26743006_Chip-Seq_LNCaP_Human1.33147141
46PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.31413602
47KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.30615994
48KDM2B_26808549_Chip-Seq_DND41_Human1.29509466
49* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.28888468
50* HNF4A_19822575_ChIP-Seq_HepG2_Human1.27829852
51CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.27804764
52ATF3_27146783_Chip-Seq_COLON_Human1.23397574
53KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23275490
54ESR1_15608294_ChIP-ChIP_MCF-7_Human1.23058245
55STAT3_1855785_ChIP-Seq_MESCs_Mouse1.20970612
56TP53_22127205_ChIP-Seq_IMR90_Human1.17398557
57* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.17309818
58RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.15764210
59HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.14178648
60SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.14043239
61SOX2_27498859_Chip-Seq_STOMACH_Mouse1.12082722
62CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.11979893
63NCOR1_26117541_ChIP-Seq_K562_Human1.11916584
64PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.11825376
65ERG_21242973_ChIP-ChIP_JURKAT_Human1.11509279
66PHF8_20622854_ChIP-Seq_HELA_Human1.11423593
67* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.11223075
68* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.10238980
69TRIM28_21343339_ChIP-Seq_HEK293_Human1.09694515
70RUNX1_27514584_Chip-Seq_MCF-7_Human1.08907954
71GATA1_22383799_ChIP-Seq_G1ME_Mouse1.08058400
72MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.06721650
73CLOCK_20551151_ChIP-Seq_293T_Human1.06445452
74P300_27058665_Chip-Seq_ZR-75-30cells_Human1.06308441
75TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05429392
76HIF1A_21447827_ChIP-Seq_MCF-7_Human1.02629455
77ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02450574
78HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.02411644
79CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.01376251
80ESR2_21235772_ChIP-Seq_MCF-7_Human0.99967413
81* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.99498478
82LXR_22292898_ChIP-Seq_THP-1_Human0.99334272
83TP63_22573176_ChIP-Seq_HFKS_Human0.98907657
84* ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.98859443
85STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.96315391
86TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.96097730
87RARB_24833708_ChIP-Seq_LIVER_Mouse0.95410232
88PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.91747373
89RARA_24833708_ChIP-Seq_LIVER_Mouse0.90948553
90ZNF263_19887448_ChIP-Seq_K562_Human0.90937710
91PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.87893440
92NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.87440610
93ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.83466513
94RAD21_21589869_ChIP-Seq_MESCs_Mouse0.82312457
95BCOR_27268052_Chip-Seq_Bcells_Human0.75670756
96* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.75501434
97TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.75456401
98NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.75158708
99* TET1_21451524_ChIP-Seq_MESCs_Mouse0.73435896
100SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.70869401
101AUTS2_25519132_ChIP-Seq_293T-REX_Human0.69977937
102CTCF_27219007_Chip-Seq_Bcells_Human0.68568897
103OCT4_20526341_ChIP-Seq_ESCs_Human0.68471066
104MYC_19915707_ChIP-ChIP_AK7_Human0.66980064
105* GATA4_25053715_ChIP-Seq_YYC3_Human0.65941202
106SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.65359131
107GATA1_22025678_ChIP-Seq_K562_Human0.62949849
108IRF1_19129219_ChIP-ChIP_H3396_Human0.61206815
109GATA1_19941826_ChIP-Seq_K562_Human0.61185317
110RACK7_27058665_Chip-Seq_MCF-7_Human0.59600383
111PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.56553659
112E2F1_20622854_ChIP-Seq_HELA_Human0.56020482
113CTCF_20526341_ChIP-Seq_ESCs_Human0.55431146
114BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.55368405
115SA1_27219007_Chip-Seq_Bcells_Human0.54973744
116BCL6_27268052_Chip-Seq_Bcells_Human0.54855900
117* ESET_19884257_ChIP-Seq_ESCs_Mouse0.54675971
118SPI1_26923725_Chip-Seq_HPCs_Mouse0.54633285
119AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.54618772
120NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.54511223
121CDX2_20551321_ChIP-Seq_CACO-2_Human0.53467464
122P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.53298080
123DNAJC2_21179169_ChIP-ChIP_NT2_Human0.53117500
124CBP_21632823_ChIP-Seq_H3396_Human0.52850742
125FOXA1_25552417_ChIP-Seq_VCAP_Human0.52742807
126RARG_19884340_ChIP-ChIP_MEFs_Mouse0.52154785
127CEBPB_22108803_ChIP-Seq_LS180_Human0.51739700
128KAP1_22055183_ChIP-Seq_ESCs_Mouse0.51499200
129CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.51194159
130MYC_27129775_Chip-Seq_CORNEA_Mouse0.50978788
131P53_21459846_ChIP-Seq_SAOS-2_Human0.50876438
132SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.50743213
133* ETS1_21867929_ChIP-Seq_TH2_Mouse0.50662261
134POU5F1_16518401_ChIP-PET_MESCs_Mouse0.50481590
135PU.1_20513432_ChIP-Seq_Bcells_Mouse0.49472587
136GATA1_19941827_ChIP-Seq_MEL_Mouse0.49363590
137CSB_26484114_Chip-Seq_FIBROBLAST_Human0.49168373
138EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.49051043
139EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.48831486
140FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.48552195
141NANOG_20526341_ChIP-Seq_ESCs_Human0.48427251
142PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.48198290
143MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.48173960
144FLI1_21867929_ChIP-Seq_CD8_Mouse0.47789430
145NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.47594462
146P68_20966046_ChIP-Seq_HELA_Human0.46804790
147EGR1_19032775_ChIP-ChIP_M12_Human0.46696234
148CTCF_21964334_ChIP-Seq_BJAB-B_Human0.45552041
149STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.45286601
150SALL4_18804426_ChIP-ChIP_XEN_Mouse0.44821425
151PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.44416686
152P300_27268052_Chip-Seq_Bcells_Human0.44195596
153TAF2_19829295_ChIP-Seq_ESCs_Human0.44041470
154NCOR_22424771_ChIP-Seq_293T_Human0.43895363

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.99132357
2MP0005360_urolithiasis7.23672565
3MP0005085_abnormal_gallbladder_physiolo6.27342940
4MP0005365_abnormal_bile_salt5.94052850
5MP0008875_abnormal_xenobiotic_pharmacok5.00807655
6MP0003806_abnormal_nucleotide_metabolis4.58790411
7MP0009840_abnormal_foam_cell3.68844980
8MP0003252_abnormal_bile_duct3.56825215
9MP0010329_abnormal_lipoprotein_level3.31657442
10MP0005083_abnormal_biliary_tract3.17436950
11MP0003195_calcinosis2.97032277
12MP0005332_abnormal_amino_acid2.92976369
13MP0001666_abnormal_nutrient_absorption2.70091129
14* MP0002118_abnormal_lipid_homeostasis2.21904917
15MP0000566_synostosis2.18099567
16MP0003191_abnormal_cellular_cholesterol2.16984395
17MP0004019_abnormal_vitamin_homeostasis2.14096293
18* MP0000609_abnormal_liver_physiology1.99132606
19MP0005451_abnormal_body_composition1.94753181
20MP0002089_abnormal_postnatal_growth/wei1.93742500
21MP0004185_abnormal_adipocyte_glucose1.80323920
22MP0000678_abnormal_parathyroid_gland1.71441324
23MP0003566_abnormal_cell_adhesion1.66377815
24MP0005584_abnormal_enzyme/coenzyme_acti1.65223732
25MP0005319_abnormal_enzyme/_coenzyme1.65160322
26MP0003656_abnormal_erythrocyte_physiolo1.65005369
27MP0010234_abnormal_vibrissa_follicle1.64924361
28MP0003868_abnormal_feces_composition1.64535273
29MP0005409_darkened_coat_color1.61794643
30MP0001764_abnormal_homeostasis1.56908455
31MP0005410_abnormal_fertilization1.45239187
32MP0005076_abnormal_cell_differentiation1.44059319
33MP0000003_abnormal_adipose_tissue1.41020214
34MP0005375_adipose_tissue_phenotype1.40921920
35MP0009780_abnormal_chondrocyte_physiolo1.39211545
36MP0002138_abnormal_hepatobiliary_system1.38995190
37MP0001849_ear_inflammation1.37765254
38MP0002249_abnormal_larynx_morphology1.34565720
39MP0003329_amyloid_beta_deposits1.34450491
40MP0003690_abnormal_glial_cell1.33741112
41MP0000604_amyloidosis1.31550088
42MP0005257_abnormal_intraocular_pressure1.29691869
43MP0004272_abnormal_basement_membrane1.27275214
44MP0008438_abnormal_cutaneous_collagen1.26874227
45MP0000920_abnormal_myelination1.24913594
46MP0003879_abnormal_hair_cell1.21669414
47MP0003186_abnormal_redox_activity1.21432261
48MP0004264_abnormal_extraembryonic_tissu1.21076261
49MP0003011_delayed_dark_adaptation1.18238693
50MP0004858_abnormal_nervous_system1.17671106
51MP0009643_abnormal_urine_homeostasis1.16067726
52MP0009697_abnormal_copulation1.12912927
53MP0001915_intracranial_hemorrhage1.12542401
54MP0005647_abnormal_sex_gland1.04241056
55MP0004233_abnormal_muscle_weight1.02848472
56MP0003123_paternal_imprinting1.01337129
57MP0006036_abnormal_mitochondrial_physio1.01315959
58* MP0000598_abnormal_liver_morphology1.00089369
59MP0000751_myopathy0.94640516
60MP0001661_extended_life_span0.92484732
61MP0005636_abnormal_mineral_homeostasis0.91816643
62MP0001348_abnormal_lacrimal_gland0.91686709
63MP0005408_hypopigmentation0.90659922
64MP0000858_altered_metastatic_potential0.89374072
65MP0002877_abnormal_melanocyte_morpholog0.88833081
66MP0000639_abnormal_adrenal_gland0.84215441
67MP0005501_abnormal_skin_physiology0.82796430
68MP0005330_cardiomyopathy0.82169948
69MP0009763_increased_sensitivity_to0.82050592
70MP0009115_abnormal_fat_cell0.81663696
71MP0005376_homeostasis/metabolism_phenot0.81058779
72MP0005058_abnormal_lysosome_morphology0.79723011
73* MP0009642_abnormal_blood_homeostasis0.78355181
74MP0005266_abnormal_metabolism0.78285670
75MP0002971_abnormal_brown_adipose0.78281611
76MP0009765_abnormal_xenobiotic_induced0.75921499
77MP0004142_abnormal_muscle_tone0.75677629
78MP0009764_decreased_sensitivity_to0.74928932
79MP0005023_abnormal_wound_healing0.72673149
80MP0000579_abnormal_nail_morphology0.72452802
81MP0004381_abnormal_hair_follicle0.72182302
82MP0001730_embryonic_growth_arrest0.71048251
83MP0009384_cardiac_valve_regurgitation0.70504729
84MP0003718_maternal_effect0.70194449
85MP0008469_abnormal_protein_level0.69343408
86MP0005220_abnormal_exocrine_pancreas0.68678526
87MP0010630_abnormal_cardiac_muscle0.68661966
88MP0002078_abnormal_glucose_homeostasis0.67700373
89MP0002822_catalepsy0.66075578
90MP0005535_abnormal_body_temperature0.63741767
91MP0002876_abnormal_thyroid_physiology0.62746687
92MP0003183_abnormal_peptide_metabolism0.62688602
93MP0006138_congestive_heart_failure0.62632639
94MP0004130_abnormal_muscle_cell0.62421139
95MP0005334_abnormal_fat_pad0.61759464
96MP0006035_abnormal_mitochondrial_morpho0.58908520
97MP0000681_abnormal_thyroid_gland0.58435131
98MP0005377_hearing/vestibular/ear_phenot0.57936198
99MP0003878_abnormal_ear_physiology0.57936198
100MP0004087_abnormal_muscle_fiber0.57923337
101MP0004043_abnormal_pH_regulation0.57741022
102MP0003091_abnormal_cell_migration0.56267609
103MP0005623_abnormal_meninges_morphology0.56264652
104MP0005448_abnormal_energy_balance0.56177870
105MP0008874_decreased_physiological_sensi0.56018720
106MP0004782_abnormal_surfactant_physiolog0.55333776
107MP0005670_abnormal_white_adipose0.54707997
108MP0005395_other_phenotype0.53770265
109MP0005084_abnormal_gallbladder_morpholo0.53769525
110MP0001881_abnormal_mammary_gland0.52445654
111MP0003115_abnormal_respiratory_system0.52253696
112MP0006082_CNS_inflammation0.50605189
113MP0000462_abnormal_digestive_system0.50541429
114MP0002254_reproductive_system_inflammat0.50473527
115MP0004885_abnormal_endolymph0.49058446
116MP0003959_abnormal_lean_body0.48493495
117MP0001765_abnormal_ion_homeostasis0.48318433
118MP0003632_abnormal_nervous_system0.48040792
119MP0001756_abnormal_urination0.47134146
120MP0003638_abnormal_response/metabolism_0.47048483
121MP0008873_increased_physiological_sensi0.46025076
122MP0002796_impaired_skin_barrier0.45648726
123MP0005075_abnormal_melanosome_morpholog0.45604455
124MP0003075_altered_response_to0.45170727
125MP0002229_neurodegeneration0.42533125
126MP0008260_abnormal_autophagy0.41581304
127MP0008872_abnormal_physiological_respon0.41552140
128MP0005464_abnormal_platelet_physiology0.39908982
129MP0003953_abnormal_hormone_level0.39867186
130MP0004147_increased_porphyrin_level0.39027184
131MP0003453_abnormal_keratinocyte_physiol0.38162594
132MP0003634_abnormal_glial_cell0.37132980
133MP0003631_nervous_system_phenotype0.36153783
134MP0000467_abnormal_esophagus_morphology0.34803189
135MP0003633_abnormal_nervous_system0.34779839
136MP0003705_abnormal_hypodermis_morpholog0.33979060
137MP0002269_muscular_atrophy0.33557976
138MP0002132_abnormal_respiratory_system0.33241733
139MP0002136_abnormal_kidney_physiology0.32562008
140MP0001324_abnormal_eye_pigmentation0.31804588
141MP0003172_abnormal_lysosome_physiology0.31685533
142MP0002970_abnormal_white_adipose0.28115509
143MP0010368_abnormal_lymphatic_system0.28048681
144MP0000747_muscle_weakness0.26387644
145MP0005666_abnormal_adipose_tissue0.25973883
146MP0000230_abnormal_systemic_arterial0.25857604
147MP0009672_abnormal_birth_weight0.25212812

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.32060777
2Intrahepatic cholestasis (HP:0001406)7.10871949
3Deep venous thrombosis (HP:0002625)6.56209441
4Hypobetalipoproteinemia (HP:0003563)6.08575067
5Xanthomatosis (HP:0000991)5.94915818
6Abnormality of monocarboxylic acid metabolism (HP:0010996)5.93357428
7Prolonged partial thromboplastin time (HP:0003645)5.83913474
8Hyperlipoproteinemia (HP:0010980)5.31541603
9Hyperglycinemia (HP:0002154)4.47794734
10Complement deficiency (HP:0004431)4.36139834
11Hyperammonemia (HP:0001987)4.31761807
12Hypolipoproteinemia (HP:0010981)4.27267414
13Ketosis (HP:0001946)4.22509877
14Abnormality of glycine metabolism (HP:0010895)4.20404093
15Abnormality of serine family amino acid metabolism (HP:0010894)4.20404093
16Epidermoid cyst (HP:0200040)4.15247584
17Joint hemorrhage (HP:0005261)4.05244364
18Abnormality of methionine metabolism (HP:0010901)4.02040407
19Fat malabsorption (HP:0002630)3.99710904
20Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.94645119
21Abnormality of aspartate family amino acid metabolism (HP:0010899)3.93693631
22Abnormality of sulfur amino acid metabolism (HP:0004339)3.93213551
23Hyperglycinuria (HP:0003108)3.90609985
24Abnormality of glutamine family amino acid metabolism (HP:0010902)3.79415369
25Abnormality of the common coagulation pathway (HP:0010990)3.61075329
26Hypoalphalipoproteinemia (HP:0003233)3.47790021
27Conjugated hyperbilirubinemia (HP:0002908)3.41261188
28Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.33289038
29Abnormality of fatty-acid metabolism (HP:0004359)3.25508376
30Hypercholesterolemia (HP:0003124)3.18532158
31Steatorrhea (HP:0002570)3.15459777
32Abnormality of the Achilles tendon (HP:0005109)3.14702040
33Hypoglycemic coma (HP:0001325)3.14447917
34Hyperbilirubinemia (HP:0002904)3.11332047
35Delayed CNS myelination (HP:0002188)3.08920390
36Abnormality of pyrimidine metabolism (HP:0004353)3.05820935
37Abnormality of complement system (HP:0005339)3.05075213
38Ketoacidosis (HP:0001993)3.02695380
39Abnormality of the intrinsic pathway (HP:0010989)3.01741752
40Abnormality of serum amino acid levels (HP:0003112)3.01397135
41Reticulocytosis (HP:0001923)3.00264535
42Hypochromic microcytic anemia (HP:0004840)2.98614187
43Protrusio acetabuli (HP:0003179)2.78331948
44Spontaneous abortion (HP:0005268)2.71047595
45Achilles tendon contracture (HP:0001771)2.70450528
46Metabolic acidosis (HP:0001942)2.68431028
47Lethargy (HP:0001254)2.68003839
48Acanthocytosis (HP:0001927)2.67779433
49Vertebral compression fractures (HP:0002953)2.61934709
50Abnormality of nucleobase metabolism (HP:0010932)2.60979280
51Myocardial infarction (HP:0001658)2.60079634
52Abnormality of carpal bone ossification (HP:0006257)2.58871008
53Abnormality of dicarboxylic acid metabolism (HP:0010995)2.57178482
54Dicarboxylic aciduria (HP:0003215)2.57178482
55Irritability (HP:0000737)2.54845416
56Vascular calcification (HP:0004934)2.53831547
57Abnormal gallbladder morphology (HP:0012437)2.52942691
58Flat acetabular roof (HP:0003180)2.51814178
59Opisthotonus (HP:0002179)2.51153335
60Spastic paraparesis (HP:0002313)2.44628674
61Cholecystitis (HP:0001082)2.44277943
62Abnormal gallbladder physiology (HP:0012438)2.44277943
63Gout (HP:0001997)2.43967936
64Distal upper limb amyotrophy (HP:0007149)2.43430812
65Upper limb amyotrophy (HP:0009129)2.43430812
66Ulnar bowing (HP:0003031)2.41246761
67Brushfield spots (HP:0001088)2.39138830
68Abnormality of purine metabolism (HP:0004352)2.38558453
69Skin nodule (HP:0200036)2.37281121
70Malnutrition (HP:0004395)2.37255984
71Cerebral edema (HP:0002181)2.36792520
72Neurofibrillary tangles (HP:0002185)2.35774604
73Hypertriglyceridemia (HP:0002155)2.34102384
74Amyloidosis (HP:0011034)2.32707137
75Purpura (HP:0000979)2.32642211
76Cholelithiasis (HP:0001081)2.31833703
77Stridor (HP:0010307)2.26646878
78Abnormal ossification of hand bones (HP:0005921)2.17349184
79Hyperacusis (HP:0010780)2.17338073
80Back pain (HP:0003418)2.16323686
81Cardiovascular calcification (HP:0011915)2.15272995
82Turricephaly (HP:0000262)2.14940938
83Hepatocellular carcinoma (HP:0001402)2.14559646
84Mitral stenosis (HP:0001718)2.14202622
85Vomiting (HP:0002013)2.13499651
86Hypoglycemic seizures (HP:0002173)2.10742705
87Spastic diplegia (HP:0001264)2.09404749
88Hypophosphatemic rickets (HP:0004912)2.09013495
89Premature rupture of membranes (HP:0001788)2.07342426
90Rickets (HP:0002748)2.07167534
91Abnormality of glycolysis (HP:0004366)2.03891479
92Increased serum pyruvate (HP:0003542)2.03891479
93Cerebral aneurysm (HP:0004944)2.03184980
94Abnormality of the gallbladder (HP:0005264)2.01498721
95Abnormal enzyme/coenzyme activity (HP:0012379)2.00949373
96Neonatal death (HP:0003811)2.00285014
97Paraparesis (HP:0002385)1.98749042
98Neonatal onset (HP:0003623)1.96399886
99Systemic lupus erythematosus (HP:0002725)1.95662541
100Hand muscle atrophy (HP:0009130)1.94491937
101Abnormality of vitamin metabolism (HP:0100508)1.94388371
102Generalized aminoaciduria (HP:0002909)1.93805442
103Alkalosis (HP:0001948)1.93506756
104Pancreatitis (HP:0001733)1.92745438
105Nephritis (HP:0000123)1.92114082
106Distal lower limb amyotrophy (HP:0008944)1.90348447
107Gingival bleeding (HP:0000225)1.88831341
108Biconcave vertebral bodies (HP:0004586)1.88748623
109Poikilocytosis (HP:0004447)1.88600458
110Acanthosis nigricans (HP:0000956)1.87580558
111Polycythemia (HP:0001901)1.87089152
112Distal lower limb muscle weakness (HP:0009053)1.86246104
113Sensorimotor neuropathy (HP:0007141)1.86099650
114Acute hepatic failure (HP:0006554)1.85951403
115Hemorrhage of the eye (HP:0011885)1.85345857
116Late onset (HP:0003584)1.83377153
117Abnormal tarsal ossification (HP:0008369)1.81656748
118Thin bony cortex (HP:0002753)1.80945318
119Enlarged kidneys (HP:0000105)1.80150825
120Glomerulonephritis (HP:0000099)1.79824066
121Hydroxyprolinuria (HP:0003080)1.79796609
122Abnormality of proline metabolism (HP:0010907)1.79796609
123Delayed myelination (HP:0012448)1.78556539
124Abnormality of alkaline phosphatase activity (HP:0004379)1.78117473
125Cerebral inclusion bodies (HP:0100314)1.77886651
126Confusion (HP:0001289)1.76621998
127Atelectasis (HP:0100750)1.76337963
128Abnormal hand bone ossification (HP:0010660)1.76189791
129Abnormality of the acetabulum (HP:0003170)1.75737069
130Seborrheic dermatitis (HP:0001051)1.75695884
131Increased connective tissue (HP:0009025)1.74112237
132Abnormality of iron homeostasis (HP:0011031)1.73780261
133Menorrhagia (HP:0000132)1.73546997
134Asymmetry of the thorax (HP:0001555)1.72333485
135Abnormality of transition element cation homeostasis (HP:0011030)1.72060665
136Glycosuria (HP:0003076)1.71047015
137Cervical subluxation (HP:0003308)1.70701605
138Increased serum ferritin (HP:0003281)1.70083355
139Abnormality of reticulocytes (HP:0004312)1.69807866
140Rhabdomyolysis (HP:0003201)1.68447902
141Advanced eruption of teeth (HP:0006288)1.66919229
142Abnormality of the thoracic spine (HP:0100711)1.64297082
143Self-mutilation (HP:0000742)1.63679195
144Short nail (HP:0001799)1.62544721
145Bronchomalacia (HP:0002780)1.61615353
146Focal segmental glomerulosclerosis (HP:0000097)1.61332255
147Impaired pain sensation (HP:0007328)1.60999533
148Abnormality of pain sensation (HP:0010832)1.60999533
149Abnormal delivery (HP:0001787)1.60010622
150Growth hormone excess (HP:0000845)1.59838749
151Elevated alkaline phosphatase (HP:0003155)1.59216851
152Glomerulosclerosis (HP:0000096)1.59106795
153Centrally nucleated skeletal muscle fibers (HP:0003687)1.58835452
154Insomnia (HP:0100785)1.58567217

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.58086222
2ICK3.91050428
3MAPK153.50831309
4SIK13.35049344
5STK393.27939431
6SMG13.00532871
7FGFR42.97358212
8OXSR12.78451993
9PINK12.67886555
10EPHA22.65652721
11EPHB12.64366700
12TESK12.62231331
13RIPK12.54945616
14EEF2K2.50912897
15IRAK32.45312812
16ERBB42.36476859
17ERN12.28557042
18MET1.97212263
19CDK121.96911989
20NME21.76435307
21PKN11.74526352
22CDK191.72863919
23SCYL21.66655101
24MAP3K111.64762482
25WNK41.64642731
26FGFR21.62154978
27FGR1.61132680
28UHMK11.60559945
29PRPF4B1.59271626
30DDR21.58024531
31TAOK31.56747904
32MAPK111.56416895
33INSRR1.55202432
34CSNK1G11.50014631
35MAP3K61.47075768
36CSNK1G31.46038572
37PDGFRA1.42303824
38KSR21.38980657
39TYRO31.34495577
40LMTK21.33830345
41DYRK1B1.32111421
42PBK1.29194857
43CSK1.29131010
44PRKD31.25973705
45CAMK2G1.25089072
46MST1R1.23045438
47CSNK1A1L1.20023650
48MAP2K31.19961055
49LATS21.17733267
50TAOK21.15359691
51TTN1.12957762
52FGFR31.12849476
53BCR1.11852675
54GSK3A1.08932788
55PAK41.08124824
56CSNK1G21.03028061
57STK161.00581466
58MAP3K10.99041162
59BMX0.98411191
60MAP3K30.96634262
61STK380.96492132
62EPHA40.95882390
63PRKAA20.95806136
64MATK0.94887048
65MAP2K40.93157079
66PRKCZ0.88602163
67CAMK2B0.86705080
68MAPK40.85092386
69RET0.84213057
70CDK70.82680668
71ABL20.82121633
72MAP3K70.80922808
73PRKG20.80168087
74DAPK20.79110031
75SGK2230.78353426
76SGK4940.78353426
77TESK20.74985371
78PIK3CG0.74851493
79MAPKAPK30.74821910
80MAP3K80.74687002
81BRAF0.73941016
82MAP3K20.71524407
83PHKG10.69593331
84PHKG20.69593331
85JAK20.68986819
86CDC42BPA0.68920688
87PDPK10.66821045
88PRKAA10.65924469
89MAP3K100.64723499
90MAP3K130.63961205
91PAK20.62514570
92PRKCQ0.61698460
93PRKACG0.61659405
94AKT30.60607236
95TAOK10.58624368
96CDK40.58596051
97RPS6KA20.56927886
98MAP2K20.56907422
99FLT30.56040017
100CAMK2D0.55449965
101NTRK10.53861744
102PRKD20.53852746
103TNIK0.53422265
104RAF10.53316715
105ARAF0.52189377
106AKT20.51668093
107ERBB20.50175736
108TYK20.49126659
109RPS6KB20.48777348
110PTK20.48306232
111SIK20.48248982
112DAPK30.47729081
113TRIB30.47291833
114ILK0.46816840
115PRKD10.46255101
116PTK60.46081227
117GRK60.45350188
118DAPK10.44284785
119MAPK120.43993443
120CAMK1D0.43057476
121AURKA0.42895631
122BRSK10.42594514
123LIMK10.42304656
124MAPK70.41537964
125IRAK20.41533211
126CAMK2A0.41043401
127TBK10.40206107
128MAP3K90.39009053
129PAK30.38863283
130MAP2K10.36601428
131DYRK20.36060239
132PIM20.35696977
133LRRK20.33576721
134CSF1R0.33117370
135EIF2AK10.32843988
136PAK60.32755003
137CDK11A0.32665922
138CDK80.30889508
139CAMKK10.30746980
140PDK10.29628173
141MTOR0.28560756
142CDK150.28114994
143PRKACB0.28055958
144PKN20.27387847
145EGFR0.27318223
146KDR0.27131490
147PAK10.27071482
148CDK90.26938638
149NEK60.26794784
150CDK60.26236037
151MAPKAPK50.25774493
152PRKACA0.25703352
153RPS6KC10.25583044
154PRKCG0.25007686
155IRAK10.24779179
156MARK20.22817723
157ABL10.22230360

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.04369433
2Nitrogen metabolism_Homo sapiens_hsa009103.10965984
3Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.04391571
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.93510599
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.83437473
6Arginine biosynthesis_Homo sapiens_hsa002202.74973712
7Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.73391099
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.59724681
9Tryptophan metabolism_Homo sapiens_hsa003802.50487497
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.46621607
11Butanoate metabolism_Homo sapiens_hsa006502.39519045
12Fatty acid degradation_Homo sapiens_hsa000712.37049904
13Steroid biosynthesis_Homo sapiens_hsa001002.34353174
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.29352572
15Complement and coagulation cascades_Homo sapiens_hsa046102.26596243
16Fatty acid elongation_Homo sapiens_hsa000622.12447712
17Fatty acid metabolism_Homo sapiens_hsa012122.11936896
18Peroxisome_Homo sapiens_hsa041462.09193909
19Pentose and glucuronate interconversions_Homo sapiens_hsa000402.07477831
20Propanoate metabolism_Homo sapiens_hsa006402.00961024
21Histidine metabolism_Homo sapiens_hsa003401.99804156
22Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.99348270
23Other glycan degradation_Homo sapiens_hsa005111.84342512
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.78764291
25Chemical carcinogenesis_Homo sapiens_hsa052041.74032192
26Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.73880293
27PPAR signaling pathway_Homo sapiens_hsa033201.73658766
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.63905539
29Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.63565072
30beta-Alanine metabolism_Homo sapiens_hsa004101.61931074
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.58180822
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.56883269
33Retinol metabolism_Homo sapiens_hsa008301.55199253
34Sulfur metabolism_Homo sapiens_hsa009201.54050049
35Selenocompound metabolism_Homo sapiens_hsa004501.53179289
36Vitamin B6 metabolism_Homo sapiens_hsa007501.52717332
37Drug metabolism - other enzymes_Homo sapiens_hsa009831.51240796
38Caffeine metabolism_Homo sapiens_hsa002321.49868006
39Folate biosynthesis_Homo sapiens_hsa007901.49639557
40Pyruvate metabolism_Homo sapiens_hsa006201.44500797
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.43200264
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.39821249
43Staphylococcus aureus infection_Homo sapiens_hsa051501.35418822
44Bile secretion_Homo sapiens_hsa049761.35417082
45Phenylalanine metabolism_Homo sapiens_hsa003601.34982756
46Arginine and proline metabolism_Homo sapiens_hsa003301.34819593
47Tyrosine metabolism_Homo sapiens_hsa003501.32049337
48Biosynthesis of amino acids_Homo sapiens_hsa012301.27322932
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.26549511
50Fat digestion and absorption_Homo sapiens_hsa049751.20413207
51Fatty acid biosynthesis_Homo sapiens_hsa000611.20166376
52ABC transporters_Homo sapiens_hsa020101.19337262
53Starch and sucrose metabolism_Homo sapiens_hsa005001.12078038
54Sulfur relay system_Homo sapiens_hsa041221.10944390
55Maturity onset diabetes of the young_Homo sapiens_hsa049501.09614844
56Carbon metabolism_Homo sapiens_hsa012001.08455340
57Cyanoamino acid metabolism_Homo sapiens_hsa004601.04811390
58Vitamin digestion and absorption_Homo sapiens_hsa049771.00687497
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.92396200
60Central carbon metabolism in cancer_Homo sapiens_hsa052300.91636821
61Glutathione metabolism_Homo sapiens_hsa004800.86649620
62Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.86031877
63Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.83419084
64Lysine degradation_Homo sapiens_hsa003100.75704154
65N-Glycan biosynthesis_Homo sapiens_hsa005100.75648461
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75543419
67Glycerolipid metabolism_Homo sapiens_hsa005610.74798587
68Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.70658988
69Pentose phosphate pathway_Homo sapiens_hsa000300.58520855
70* Metabolic pathways_Homo sapiens_hsa011000.58022542
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56719743
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.52252988
73Chronic myeloid leukemia_Homo sapiens_hsa052200.50402666
74Non-small cell lung cancer_Homo sapiens_hsa052230.49329715
75Acute myeloid leukemia_Homo sapiens_hsa052210.47237847
76One carbon pool by folate_Homo sapiens_hsa006700.44366571
77Linoleic acid metabolism_Homo sapiens_hsa005910.43473978
78VEGF signaling pathway_Homo sapiens_hsa043700.39406738
79Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.39014615
80Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.37260805
81Thyroid cancer_Homo sapiens_hsa052160.37216258
82Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.36439927
83Fructose and mannose metabolism_Homo sapiens_hsa000510.34257693
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.32030119
85Vibrio cholerae infection_Homo sapiens_hsa051100.31666625
86* Glycerophospholipid metabolism_Homo sapiens_hsa005640.28506409
87Prion diseases_Homo sapiens_hsa050200.27957888
88Thyroid hormone synthesis_Homo sapiens_hsa049180.27330174
89Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.26159750
90Endometrial cancer_Homo sapiens_hsa052130.25248744
91Ether lipid metabolism_Homo sapiens_hsa005650.25068932
92Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.24755113
93Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.24331505
94mTOR signaling pathway_Homo sapiens_hsa041500.23255505
95Galactose metabolism_Homo sapiens_hsa000520.20763609
96Focal adhesion_Homo sapiens_hsa045100.20628304
97Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.20578324
98Carbohydrate digestion and absorption_Homo sapiens_hsa049730.19800094
99ECM-receptor interaction_Homo sapiens_hsa045120.19782107
100Endocytosis_Homo sapiens_hsa041440.18444556
101Pancreatic cancer_Homo sapiens_hsa052120.17866426
102ErbB signaling pathway_Homo sapiens_hsa040120.16725766
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.15910813
104Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.08280676
105Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.03337281
106Insulin resistance_Homo sapiens_hsa049310.02814735
107Regulation of autophagy_Homo sapiens_hsa041400.01991654
108AMPK signaling pathway_Homo sapiens_hsa041520.01560496
109Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533-0.2595472
110Bladder cancer_Homo sapiens_hsa05219-0.2521286
111Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.2408154
112Hepatitis C_Homo sapiens_hsa05160-0.2209679
113Sphingolipid metabolism_Homo sapiens_hsa00600-0.2146264
114Insulin signaling pathway_Homo sapiens_hsa04910-0.2047853
115African trypanosomiasis_Homo sapiens_hsa05143-0.2038355
116Alzheimers disease_Homo sapiens_hsa05010-0.2003277
117Circadian rhythm_Homo sapiens_hsa04710-0.1862928
118Parkinsons disease_Homo sapiens_hsa05012-0.1784122
119Lysosome_Homo sapiens_hsa04142-0.1302972
120Renin-angiotensin system_Homo sapiens_hsa04614-0.1238722
121Mineral absorption_Homo sapiens_hsa04978-0.0909464
122Glucagon signaling pathway_Homo sapiens_hsa04922-0.0755507
123Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0449177
124Oxidative phosphorylation_Homo sapiens_hsa00190-0.0274021
125Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0215334

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