PCSK9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.35489348
2L-phenylalanine catabolic process (GO:0006559)7.35489348
3L-phenylalanine metabolic process (GO:0006558)7.09949897
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.09949897
5aromatic amino acid family catabolic process (GO:0009074)6.42632332
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.23518562
7negative regulation of fibrinolysis (GO:0051918)5.74478359
8indole-containing compound catabolic process (GO:0042436)5.65312284
9indolalkylamine catabolic process (GO:0046218)5.65312284
10tryptophan catabolic process (GO:0006569)5.65312284
11kynurenine metabolic process (GO:0070189)5.63765085
12high-density lipoprotein particle remodeling (GO:0034375)5.61937364
13urea metabolic process (GO:0019627)5.60877149
14urea cycle (GO:0000050)5.60877149
15regulation of fibrinolysis (GO:0051917)5.46522140
16glyoxylate metabolic process (GO:0046487)5.43645142
17bile acid biosynthetic process (GO:0006699)5.42233542
18alpha-linolenic acid metabolic process (GO:0036109)5.35889145
19tryptophan metabolic process (GO:0006568)5.34647863
20peptidyl-glutamic acid carboxylation (GO:0017187)5.25162417
21protein carboxylation (GO:0018214)5.25162417
22sulfur amino acid catabolic process (GO:0000098)5.24673855
23cysteine metabolic process (GO:0006534)5.21925040
24regulation of protein activation cascade (GO:2000257)5.13378204
25nitrogen cycle metabolic process (GO:0071941)5.11825948
26reverse cholesterol transport (GO:0043691)5.08552915
27complement activation, alternative pathway (GO:0006957)4.97190257
28homocysteine metabolic process (GO:0050667)4.92395957
29regulation of cholesterol esterification (GO:0010872)4.88416965
30plasma lipoprotein particle remodeling (GO:0034369)4.83675658
31protein-lipid complex remodeling (GO:0034368)4.83675658
32macromolecular complex remodeling (GO:0034367)4.83675658
33serine family amino acid catabolic process (GO:0009071)4.81680548
34bile acid metabolic process (GO:0008206)4.80925629
35proline metabolic process (GO:0006560)4.75577238
36regulation of complement activation (GO:0030449)4.74977457
37triglyceride homeostasis (GO:0070328)4.71303079
38acylglycerol homeostasis (GO:0055090)4.71303079
39aromatic amino acid family metabolic process (GO:0009072)4.67002001
40negative regulation of sterol transport (GO:0032372)4.66243814
41negative regulation of cholesterol transport (GO:0032375)4.66243814
42phospholipid efflux (GO:0033700)4.65510040
43regulation of triglyceride catabolic process (GO:0010896)4.60421367
44plasma lipoprotein particle clearance (GO:0034381)4.53076178
45tyrosine metabolic process (GO:0006570)4.51451224
46lysine catabolic process (GO:0006554)4.47692924
47lysine metabolic process (GO:0006553)4.47692924
48proline biosynthetic process (GO:0006561)4.45597185
49glycine metabolic process (GO:0006544)4.43864378
50fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.40915191
51alpha-amino acid catabolic process (GO:1901606)4.39774125
52L-alpha-amino acid transmembrane transport (GO:1902475)4.39233925
53plasma lipoprotein particle assembly (GO:0034377)4.39129096
54bile acid and bile salt transport (GO:0015721)4.36908949
55cholesterol efflux (GO:0033344)4.35074812
56regulation of cholesterol homeostasis (GO:2000188)4.31693211
57amino-acid betaine metabolic process (GO:0006577)4.30804475
58cellular glucuronidation (GO:0052695)4.24249190
59regulation of cholesterol biosynthetic process (GO:0045540)4.22574499
60glutamate metabolic process (GO:0006536)4.21755646
61imidazole-containing compound metabolic process (GO:0052803)4.16158314
62serine family amino acid metabolic process (GO:0009069)4.13362364
63intestinal cholesterol absorption (GO:0030299)4.08548755
64serine family amino acid biosynthetic process (GO:0009070)4.07661021
65cellular modified amino acid catabolic process (GO:0042219)4.05202526
66cellular amino acid catabolic process (GO:0009063)4.04586295
67cellular ketone body metabolic process (GO:0046950)4.04458239
68indolalkylamine metabolic process (GO:0006586)4.01632687
69fibrinolysis (GO:0042730)4.00682705
70very-low-density lipoprotein particle assembly (GO:0034379)3.98062282
71protein-lipid complex assembly (GO:0065005)3.97989478
72low-density lipoprotein particle remodeling (GO:0034374)3.97589340
73coenzyme catabolic process (GO:0009109)3.97096635
74regulation of apoptotic cell clearance (GO:2000425)3.95150894
75phospholipid homeostasis (GO:0055091)3.92721270
76drug catabolic process (GO:0042737)3.91867308
77benzene-containing compound metabolic process (GO:0042537)3.90061211
78dicarboxylic acid biosynthetic process (GO:0043650)3.86945767
79negative regulation of protein activation cascade (GO:2000258)3.86758983
80arginine metabolic process (GO:0006525)3.85849035
81cellular biogenic amine catabolic process (GO:0042402)3.85604783
82amine catabolic process (GO:0009310)3.85604783
83nuclear pore complex assembly (GO:0051292)3.85411902
84regulation of plasminogen activation (GO:0010755)3.85280512
85ethanol oxidation (GO:0006069)3.85067652
86regulation of bile acid biosynthetic process (GO:0070857)3.82142556
87intestinal absorption (GO:0050892)3.81844339
88plasma lipoprotein particle organization (GO:0071827)3.80540673
89* cholesterol homeostasis (GO:0042632)3.79334039
90negative regulation of lipase activity (GO:0060192)3.77921533
91blood coagulation, intrinsic pathway (GO:0007597)3.77153521
92* sterol homeostasis (GO:0055092)3.74201331
93uronic acid metabolic process (GO:0006063)3.73481285
94glucuronate metabolic process (GO:0019585)3.73481285
95positive regulation of triglyceride lipase activity (GO:0061365)3.73382132
96positive regulation of lipoprotein lipase activity (GO:0051006)3.73382132
97response to nitrosative stress (GO:0051409)3.70757791
98* lipoprotein metabolic process (GO:0042157)3.70542820
99aldehyde catabolic process (GO:0046185)3.69409013
100L-serine metabolic process (GO:0006563)3.60951689
101protein-lipid complex subunit organization (GO:0071825)3.60433051
102regulation of translational fidelity (GO:0006450)3.60333780
103positive regulation of lipid catabolic process (GO:0050996)3.56971552
104cofactor catabolic process (GO:0051187)3.55645028
105protein activation cascade (GO:0072376)3.50413877
106organic acid catabolic process (GO:0016054)3.48579678
107carboxylic acid catabolic process (GO:0046395)3.48579678
108ketone body metabolic process (GO:1902224)3.48312018
109complement activation, classical pathway (GO:0006958)3.47213935
110negative regulation of complement activation (GO:0045916)3.44825116
111acute-phase response (GO:0006953)3.44425688
112acetyl-CoA metabolic process (GO:0006084)3.44253238
113heterochromatin organization (GO:0070828)3.42222153
114low-density lipoprotein particle clearance (GO:0034383)3.32658018
115establishment of apical/basal cell polarity (GO:0035089)3.23529557
116glucose 6-phosphate metabolic process (GO:0051156)3.18546586
117COPI coating of Golgi vesicle (GO:0048205)3.15483666
118Golgi transport vesicle coating (GO:0048200)3.15483666
119lung epithelium development (GO:0060428)3.14876380
120fatty acid homeostasis (GO:0055089)3.14605923
121nuclear pore organization (GO:0006999)3.14229313
122positive regulation of fatty acid biosynthetic process (GO:0045723)3.13022052
123positive regulation of hormone biosynthetic process (GO:0046886)3.06061337
124glutamine family amino acid biosynthetic process (GO:0009084)3.05359447
125regulation of cholesterol metabolic process (GO:0090181)2.95184704
126cholesterol biosynthetic process (GO:0006695)2.92914627
127DNA unwinding involved in DNA replication (GO:0006268)2.89068927
128midgut development (GO:0007494)2.88431891
129long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.88232413
130biotin metabolic process (GO:0006768)2.87032021
131positive regulation of hormone metabolic process (GO:0032352)2.86471162
132desmosome organization (GO:0002934)2.86276547
133gap junction assembly (GO:0016264)2.85398830
134basement membrane organization (GO:0071711)2.78246206
135maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.74548449
136regulation of fatty acid biosynthetic process (GO:0042304)2.66793316
137positive regulation of steroid metabolic process (GO:0045940)2.66179338
138regulation of posttranscriptional gene silencing (GO:0060147)2.65756360
139regulation of gene silencing by miRNA (GO:0060964)2.65756360
140regulation of gene silencing by RNA (GO:0060966)2.65756360
141sterol transport (GO:0015918)2.64679249
142cholesterol transport (GO:0030301)2.64679249
143pore complex assembly (GO:0046931)2.62849356
144fatty-acyl-CoA biosynthetic process (GO:0046949)2.61014772
145regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.59726806
146polarized epithelial cell differentiation (GO:0030859)2.58504811
147protein retention in ER lumen (GO:0006621)2.57653277

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.25428543
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.20718236
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.46924158
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.43391916
5E2F7_22180533_ChIP-Seq_HELA_Human5.68344368
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.18501689
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.06687183
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.58784212
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.09317726
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.02110897
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.83393412
12FOXM1_23109430_ChIP-Seq_U2OS_Human2.52951459
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.51567243
14HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.30869763
15CLOCK_20551151_ChIP-Seq_293T_Human2.10049457
16TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.08604460
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.02932114
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.01653646
19ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.7112997
20TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.95160842
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.90196317
22MYC_19030024_ChIP-ChIP_MESCs_Mouse1.87680178
23POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.86004619
24MYC_18358816_ChIP-ChIP_MESCs_Mouse1.84848814
25PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.84462843
26ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.83888861
27FOXA2_19822575_ChIP-Seq_HepG2_Human1.75568083
28GATA1_22025678_ChIP-Seq_K562_Human1.74357556
29MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.62910658
30NELFA_20434984_ChIP-Seq_ESCs_Mouse1.62828197
31NANOG_18555785_ChIP-Seq_MESCs_Mouse1.62207150
32KLF4_18555785_ChIP-Seq_MESCs_Mouse1.55814996
33ZFX_18555785_ChIP-Seq_MESCs_Mouse1.54985420
34XRN2_22483619_ChIP-Seq_HELA_Human1.53996433
35* HNF4A_19822575_ChIP-Seq_HepG2_Human1.53904613
36DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.51991062
37ESR1_15608294_ChIP-ChIP_MCF-7_Human1.50403834
38SOX2_27498859_Chip-Seq_STOMACH_Mouse1.49205206
39MYC_22102868_ChIP-Seq_BL_Human1.46771954
40CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.46384450
41CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.36695875
42KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.36272815
43EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36266924
44HIF1A_21447827_ChIP-Seq_MCF-7_Human1.34772598
45TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33989521
46HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.31246193
47MYCN_18555785_ChIP-Seq_MESCs_Mouse1.30380819
48E2F1_18555785_ChIP-Seq_MESCs_Mouse1.29331007
49FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.29188677
50NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.24566695
51KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.23802183
52POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.23585239
53STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.22824319
54GATA4_25053715_ChIP-Seq_YYC3_Human1.22777021
55HTT_18923047_ChIP-ChIP_STHdh_Human1.20238440
56ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.19691925
57STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.19657055
58SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.19268792
59CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.17544280
60ELK3_25401928_ChIP-Seq_HUVEC_Human1.17261198
61ZFP281_18757296_ChIP-ChIP_E14_Mouse1.17091663
62E2F1_21310950_ChIP-Seq_MCF-7_Human1.15488234
63NCOR1_26117541_ChIP-Seq_K562_Human1.14555086
64NANOG_21062744_ChIP-ChIP_HESCs_Human1.13393247
65THAP11_20581084_ChIP-Seq_MESCs_Mouse1.13299552
66DCP1A_22483619_ChIP-Seq_HELA_Human1.11833575
67SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.10100429
68* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.09723584
69RXRA_24833708_ChIP-Seq_LIVER_Mouse1.09029337
70DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.08237413
71MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.07108380
72RARG_19884340_ChIP-ChIP_MEFs_Mouse1.06757192
73POU5F1_16518401_ChIP-PET_MESCs_Mouse1.05355626
74E2F4_17652178_ChIP-ChIP_JURKAT_Human1.05141072
75TCF3_18692474_ChIP-Seq_MEFs_Mouse1.02789399
76KAP1_27257070_Chip-Seq_ESCs_Mouse1.02603653
77SOX17_20123909_ChIP-Seq_XEN_Mouse0.98775228
78TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.98323427
79* ERG_21242973_ChIP-ChIP_JURKAT_Human0.98213869
80SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.98137941
81SMC4_20622854_ChIP-Seq_HELA_Human0.97300877
82TTF2_22483619_ChIP-Seq_HELA_Human0.97029610
83CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.96256759
84P300_27058665_Chip-Seq_ZR-75-30cells_Human0.95656175
85NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.95399571
86ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.95301348
87KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.94928491
88GATA6_25053715_ChIP-Seq_YYC3_Human0.94734984
89CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.92687916
90THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.90777959
91RARA_24833708_ChIP-Seq_LIVER_Mouse0.89988527
92ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.89732551
93SALL4_18804426_ChIP-ChIP_XEN_Mouse0.87442530
94ESR2_21235772_ChIP-Seq_MCF-7_Human0.86047288
95* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.82811751
96SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.81983490
97LXR_22292898_ChIP-Seq_THP-1_Human0.81024379
98FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.79757640
99CDX2_20551321_ChIP-Seq_CACO-2_Human0.79462901
100PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.75986364
101GATA1_19941826_ChIP-Seq_K562_Human0.75017338
102CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.74681387
103BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.73640738
104RARB_24833708_ChIP-Seq_LIVER_Mouse0.71924190
105PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.71893347
106NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.71013230
107FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.69840403
108FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.66947170
109ESR1_21235772_ChIP-Seq_MCF-7_Human0.66686324
110AUTS2_25519132_ChIP-Seq_293T-REX_Human0.66634436
111FOXO3_23340844_ChIP-Seq_DLD1_Human0.66581674
112FOXA1_25552417_ChIP-Seq_VCAP_Human0.66220727
113ESR1_20079471_ChIP-ChIP_T-47D_Human0.65117283
114STAT3_1855785_ChIP-Seq_MESCs_Mouse0.62829596
115RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.62414209
116ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.62022190
117NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.61971899
118TP63_17297297_ChIP-ChIP_HaCaT_Human0.61366047
119IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.60516925
120* ZNF263_19887448_ChIP-Seq_K562_Human0.60027548
121NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.59630243
122PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.59179030
123PPAR_26484153_Chip-Seq_NCI-H1993_Human0.58706704
124* SOX2_20726797_ChIP-Seq_SW620_Human0.58672725
125* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.58056193
126* RACK7_27058665_Chip-Seq_MCF-7_Human0.58050026
127BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.57569659
128ATF3_27146783_Chip-Seq_COLON_Human0.57336445
129AR_21909140_ChIP-Seq_LNCAP_Human0.57293713
130CREB1_26743006_Chip-Seq_LNCaP_Human0.56966187
131NRF2_20460467_ChIP-Seq_MEFs_Mouse0.56446975
132NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.56446975
133GATA2_19941826_ChIP-Seq_K562_Human0.54569260
134* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.53746554
135GATA3_24758297_ChIP-Seq_MCF-7_Human0.51073138
136TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.51057657
137TRIM28_21343339_ChIP-Seq_HEK293_Human0.50474970
138CEBPB_22108803_ChIP-Seq_LS180_Human0.50444094
139NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.50287788
140Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.49270597
141RAD21_21589869_ChIP-Seq_MESCs_Mouse0.49201940
142KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.48943874
143AR_20517297_ChIP-Seq_VCAP_Human0.47843594
144MYC_19915707_ChIP-ChIP_AK7_Human0.47239974
145GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.47238115
146KAP1_22055183_ChIP-Seq_ESCs_Mouse0.46759803
147NFIB_24661679_ChIP-Seq_LUNG_Mouse0.46690706
148SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.45334969
149GATA1_19941827_ChIP-Seq_MEL_Mouse0.43456107
150ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.43305821
151CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.43186541
152CBP_21632823_ChIP-Seq_H3396_Human0.43140055
153SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.40900421
154TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.40175227
155FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.40098232
156P53_21459846_ChIP-Seq_SAOS-2_Human0.40031426
157EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.39403315
158ERG_20517297_ChIP-Seq_VCAP_Human0.38911250
159TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.37988414

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.30056831
2MP0005360_urolithiasis7.31042926
3MP0005085_abnormal_gallbladder_physiolo6.29289738
4MP0005365_abnormal_bile_salt5.96244968
5MP0008875_abnormal_xenobiotic_pharmacok4.84602110
6MP0003252_abnormal_bile_duct3.98769448
7MP0003806_abnormal_nucleotide_metabolis3.94843331
8* MP0010329_abnormal_lipoprotein_level3.50766190
9MP0005083_abnormal_biliary_tract3.38123833
10MP0009840_abnormal_foam_cell3.35887529
11MP0000566_synostosis3.14079146
12MP0003195_calcinosis3.03936029
13MP0001666_abnormal_nutrient_absorption2.86231702
14MP0003122_maternal_imprinting2.72893803
15MP0005332_abnormal_amino_acid2.58476211
16MP0004272_abnormal_basement_membrane2.23388761
17MP0000609_abnormal_liver_physiology2.20790245
18MP0002089_abnormal_postnatal_growth/wei2.20235991
19MP0003191_abnormal_cellular_cholesterol2.16647749
20MP0003123_paternal_imprinting2.13526983
21MP0003868_abnormal_feces_composition2.10263516
22MP0004019_abnormal_vitamin_homeostasis2.06565875
23MP0003566_abnormal_cell_adhesion2.06375876
24* MP0002118_abnormal_lipid_homeostasis2.03999028
25MP0004957_abnormal_blastocyst_morpholog1.99106537
26MP0002138_abnormal_hepatobiliary_system1.97205232
27MP0003941_abnormal_skin_development1.96054840
28MP0003693_abnormal_embryo_hatching1.90587513
29MP0003111_abnormal_nucleus_morphology1.90339242
30MP0005076_abnormal_cell_differentiation1.84578046
31MP0001915_intracranial_hemorrhage1.72688292
32MP0005319_abnormal_enzyme/_coenzyme1.71022642
33MP0004233_abnormal_muscle_weight1.60758429
34MP0003705_abnormal_hypodermis_morpholog1.60466531
35MP0001730_embryonic_growth_arrest1.57427725
36MP0005257_abnormal_intraocular_pressure1.56812633
37MP0005409_darkened_coat_color1.55915416
38MP0001764_abnormal_homeostasis1.43777432
39MP0003011_delayed_dark_adaptation1.40678677
40MP0005584_abnormal_enzyme/coenzyme_acti1.38133215
41MP0003890_abnormal_embryonic-extraembry1.36629183
42MP0009643_abnormal_urine_homeostasis1.35230258
43MP0008932_abnormal_embryonic_tissue1.34583768
44MP0009697_abnormal_copulation1.34553473
45MP0010030_abnormal_orbit_morphology1.33262394
46MP0001849_ear_inflammation1.32586093
47MP0000678_abnormal_parathyroid_gland1.29719268
48MP0005220_abnormal_exocrine_pancreas1.29656333
49MP0003656_abnormal_erythrocyte_physiolo1.29524245
50MP0002697_abnormal_eye_size1.27161821
51MP0000598_abnormal_liver_morphology1.24250054
52MP0003115_abnormal_respiratory_system1.20729164
53MP0005380_embryogenesis_phenotype1.20452299
54MP0001672_abnormal_embryogenesis/_devel1.20452299
55MP0004185_abnormal_adipocyte_glucose1.18566757
56MP0000003_abnormal_adipose_tissue1.17220191
57MP0010094_abnormal_chromosome_stability1.16164905
58MP0003984_embryonic_growth_retardation1.15978026
59MP0002086_abnormal_extraembryonic_tissu1.12994661
60MP0008260_abnormal_autophagy1.11987939
61MP0002088_abnormal_embryonic_growth/wei1.10363695
62MP0003172_abnormal_lysosome_physiology1.09976893
63MP0003950_abnormal_plasma_membrane1.08382720
64MP0001697_abnormal_embryo_size1.08152652
65MP0002080_prenatal_lethality1.07738309
66MP0003315_abnormal_perineum_morphology1.06833665
67MP0005451_abnormal_body_composition1.06429701
68MP0000762_abnormal_tongue_morphology1.04850740
69MP0005501_abnormal_skin_physiology1.02935988
70MP0003186_abnormal_redox_activity1.02902396
71MP0009053_abnormal_anal_canal1.01636008
72MP0005084_abnormal_gallbladder_morpholo1.01503427
73MP0005636_abnormal_mineral_homeostasis1.00630234
74MP0005408_hypopigmentation1.00177603
75MP0000604_amyloidosis0.97663080
76MP0003937_abnormal_limbs/digits/tail_de0.95786823
77MP0002254_reproductive_system_inflammat0.94207187
78MP0002078_abnormal_glucose_homeostasis0.94140378
79MP0009763_increased_sensitivity_to0.94091305
80MP0002084_abnormal_developmental_patter0.93731224
81MP0003077_abnormal_cell_cycle0.93648860
82MP0003942_abnormal_urinary_system0.92559835
83MP0003567_abnormal_fetal_cardiomyocyte0.92201979
84MP0009703_decreased_birth_body0.89878432
85MP0004197_abnormal_fetal_growth/weight/0.88818623
86* MP0009642_abnormal_blood_homeostasis0.87963728
87MP0003121_genomic_imprinting0.87890965
88MP0003119_abnormal_digestive_system0.87683819
89MP0000350_abnormal_cell_proliferation0.87565314
90MP0002111_abnormal_tail_morphology0.87505097
91MP0009764_decreased_sensitivity_to0.85755712
92MP0004858_abnormal_nervous_system0.85717376
93MP0003385_abnormal_body_wall0.83793836
94MP0002092_abnormal_eye_morphology0.83574329
95MP0002085_abnormal_embryonic_tissue0.83347063
96MP0010234_abnormal_vibrissa_follicle0.83039267
97MP0004264_abnormal_extraembryonic_tissu0.82580711
98MP0000467_abnormal_esophagus_morphology0.80873293
99MP0002938_white_spotting0.80829148
100MP0005647_abnormal_sex_gland0.80253690
101MP0010630_abnormal_cardiac_muscle0.79302787
102MP0002876_abnormal_thyroid_physiology0.79138126
103MP0008438_abnormal_cutaneous_collagen0.78351143
104MP0010368_abnormal_lymphatic_system0.77289165
105MP0008469_abnormal_protein_level0.76172467
106MP0010352_gastrointestinal_tract_polyps0.75959182
107MP0006036_abnormal_mitochondrial_physio0.75140018
108MP0005670_abnormal_white_adipose0.74955280
109MP0008007_abnormal_cellular_replicative0.74597531
110MP0002233_abnormal_nose_morphology0.74283551
111MP0000537_abnormal_urethra_morphology0.74036569
112MP0001286_abnormal_eye_development0.73899886
113MP0001944_abnormal_pancreas_morphology0.71700355
114MP0001216_abnormal_epidermal_layer0.69229508
115MP0000013_abnormal_adipose_tissue0.68423571
116MP0009765_abnormal_xenobiotic_induced0.67657110
117MP0003329_amyloid_beta_deposits0.67097413
118MP0002928_abnormal_bile_duct0.66331604
119MP0005376_homeostasis/metabolism_phenot0.66302152
120MP0005334_abnormal_fat_pad0.63917226
121MP0005448_abnormal_energy_balance0.61180253
122MP0001756_abnormal_urination0.61149800
123MP0002971_abnormal_brown_adipose0.59887609
124MP0009672_abnormal_birth_weight0.59666616
125MP0005248_abnormal_Harderian_gland0.56716489
126MP0003300_gastrointestinal_ulcer0.56661984
127MP0001661_extended_life_span0.55484045
128MP0005266_abnormal_metabolism0.55278642
129MP0005187_abnormal_penis_morphology0.53914034
130MP0000639_abnormal_adrenal_gland0.53434901
131MP0003953_abnormal_hormone_level0.49949911
132MP0005535_abnormal_body_temperature0.47374981
133MP0005167_abnormal_blood-brain_barrier0.47286459
134MP0004043_abnormal_pH_regulation0.46681778
135MP0008873_increased_physiological_sensi0.46483925
136MP0006035_abnormal_mitochondrial_morpho0.45596648
137MP0005395_other_phenotype0.44129766
138MP0002136_abnormal_kidney_physiology0.43627683
139MP0002877_abnormal_melanocyte_morpholog0.42580925
140MP0005464_abnormal_platelet_physiology0.42002765
141MP0009384_cardiac_valve_regurgitation0.41960807
142MP0002693_abnormal_pancreas_physiology0.41832904
143MP0003718_maternal_effect0.40945535
144MP0003690_abnormal_glial_cell0.40764893
145MP0004130_abnormal_muscle_cell0.40020691
146MP0005666_abnormal_adipose_tissue0.39683640
147MP0003638_abnormal_response/metabolism_0.38248055
148MP0002060_abnormal_skin_morphology0.37859341
149MP0002822_catalepsy0.35816214
150MP0005058_abnormal_lysosome_morphology0.34907331
151MP0001243_abnormal_dermal_layer0.34738182
152MP0009379_abnormal_foot_pigmentation0.33008482
153MP0009780_abnormal_chondrocyte_physiolo0.32841006
154MP0002970_abnormal_white_adipose0.32803027
155MP0002837_dystrophic_cardiac_calcinosis0.32481668
156MP0002796_impaired_skin_barrier0.32103953
157MP0003453_abnormal_keratinocyte_physiol0.31402718
158MP0002896_abnormal_bone_mineralization0.31209751
159MP0000462_abnormal_digestive_system0.30686779
160MP0000579_abnormal_nail_morphology0.30216386
161MP0005023_abnormal_wound_healing0.29876481
162MP0001881_abnormal_mammary_gland0.27711392
163MP0002168_other_aberrant_phenotype0.27463290
164MP0002909_abnormal_adrenal_gland0.26998087
165MP0000249_abnormal_blood_vessel0.26885752

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.28953689
2Intrahepatic cholestasis (HP:0001406)7.28509716
3Abnormality of aromatic amino acid family metabolism (HP:0004338)7.22607047
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.66158066
5Hypobetalipoproteinemia (HP:0003563)6.46551795
6Prolonged partial thromboplastin time (HP:0003645)6.31062345
7Xanthomatosis (HP:0000991)6.19700999
8Complement deficiency (HP:0004431)4.84173062
9Hyperlipoproteinemia (HP:0010980)4.80875657
10Hypolipoproteinemia (HP:0010981)4.76155552
11Abnormality of the common coagulation pathway (HP:0010990)4.63175865
12Joint hemorrhage (HP:0005261)4.59388811
13Epidermoid cyst (HP:0200040)4.47098620
14Hyperammonemia (HP:0001987)4.36462923
15Hypoglycemic coma (HP:0001325)4.35150548
16Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.22601580
17Abnormality of glutamine family amino acid metabolism (HP:0010902)4.21202627
18Fat malabsorption (HP:0002630)4.13497003
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.11472841
20Ketosis (HP:0001946)4.09589354
21Hyperglycinemia (HP:0002154)4.05134410
22Abnormality of the intrinsic pathway (HP:0010989)4.01795609
23Abnormality of methionine metabolism (HP:0010901)4.00016295
24Hypoalphalipoproteinemia (HP:0003233)3.97107522
25Conjugated hyperbilirubinemia (HP:0002908)3.90545229
26Abnormality of aspartate family amino acid metabolism (HP:0010899)3.86770454
27Abnormality of glycine metabolism (HP:0010895)3.63121701
28Abnormality of serine family amino acid metabolism (HP:0010894)3.63121701
29Abnormality of complement system (HP:0005339)3.59771611
30Abnormality of pyrimidine metabolism (HP:0004353)3.58757169
31Hyperbilirubinemia (HP:0002904)3.58195229
32Hyperglycinuria (HP:0003108)3.55865993
33Acanthocytosis (HP:0001927)3.31885863
34Hypoglycemic seizures (HP:0002173)3.19710022
35Ketoacidosis (HP:0001993)3.17820020
36* Hypercholesterolemia (HP:0003124)3.12662194
37Hepatocellular carcinoma (HP:0001402)3.11691431
38Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.02301796
39Abnormality of nucleobase metabolism (HP:0010932)2.98858557
40Skin nodule (HP:0200036)2.97574213
41Abnormality of glycolysis (HP:0004366)2.95883195
42Increased serum pyruvate (HP:0003542)2.89562877
43Cholecystitis (HP:0001082)2.87120547
44Abnormal gallbladder physiology (HP:0012438)2.87120547
45Hypochromic microcytic anemia (HP:0004840)2.86265939
46Abnormality of fatty-acid metabolism (HP:0004359)2.85503928
47Hyperinsulinemic hypoglycemia (HP:0000825)2.84836294
48Late onset (HP:0003584)2.83869076
49Spontaneous abortion (HP:0005268)2.83549096
50Steatorrhea (HP:0002570)2.80683427
51Abnormal gallbladder morphology (HP:0012437)2.78328910
52Delayed CNS myelination (HP:0002188)2.74570493
53Myocardial infarction (HP:0001658)2.73261734
54Abnormality of serum amino acid levels (HP:0003112)2.72993934
55Malnutrition (HP:0004395)2.71095496
56Abnormality of purine metabolism (HP:0004352)2.68909251
57Asymmetry of the thorax (HP:0001555)2.66208930
58Cholelithiasis (HP:0001081)2.63953211
59Broad alveolar ridges (HP:0000187)2.61810414
60Vaginal fistula (HP:0004320)2.61213171
61Metabolic acidosis (HP:0001942)2.59977742
62Poikilocytosis (HP:0004447)2.52749154
63Spastic diplegia (HP:0001264)2.51855181
64Overlapping toe (HP:0001845)2.47950269
65Abnormality of carpal bone ossification (HP:0006257)2.47159601
66Gout (HP:0001997)2.46093515
67Esophageal varix (HP:0002040)2.43434027
68Lethargy (HP:0001254)2.40065176
69Abnormality of dicarboxylic acid metabolism (HP:0010995)2.39104758
70Dicarboxylic aciduria (HP:0003215)2.39104758
71Vascular calcification (HP:0004934)2.38775409
72Hepatoblastoma (HP:0002884)2.35498404
73Ulnar bowing (HP:0003031)2.32584934
74Irritability (HP:0000737)2.32503856
75Impaired pain sensation (HP:0007328)2.31811551
76Abnormality of pain sensation (HP:0010832)2.31811551
77Flat acetabular roof (HP:0003180)2.31698441
78Small epiphyses (HP:0010585)2.28740402
79Symptomatic seizures (HP:0011145)2.28567578
80Abnormality of the nasal septum (HP:0000419)2.28211572
81Abnormality of the Achilles tendon (HP:0005109)2.27829469
82Systemic lupus erythematosus (HP:0002725)2.27503624
83Glomerulonephritis (HP:0000099)2.26341143
84Abnormality of the gallbladder (HP:0005264)2.26239346
85Renal duplication (HP:0000075)2.24644746
86Mitral stenosis (HP:0001718)2.21222939
87Sensorimotor neuropathy (HP:0007141)2.20219096
88Hyperglycemia (HP:0003074)2.20071926
89Ankyloglossia (HP:0010296)2.17603028
90Neonatal onset (HP:0003623)2.17277797
91Menorrhagia (HP:0000132)2.15217339
92Cerebral edema (HP:0002181)2.14466136
93Back pain (HP:0003418)2.13583332
94Amyloidosis (HP:0011034)2.13025249
95Deviation of the thumb (HP:0009603)2.12686507
96Bronchomalacia (HP:0002780)2.12435413
97Cardiovascular calcification (HP:0011915)2.12215306
98Pancreatitis (HP:0001733)2.09430149
99Increased nuchal translucency (HP:0010880)2.09036394
100Abnormality of the pancreatic islet cells (HP:0006476)2.07496142
101Abnormality of endocrine pancreas physiology (HP:0012093)2.07496142
102Abnormal cartilage morphology (HP:0002763)2.05940663
103Gingival bleeding (HP:0000225)2.04670159
104Abnormal ossification of hand bones (HP:0005921)2.04151138
105Reticulocytosis (HP:0001923)2.03881736
106Generalized aminoaciduria (HP:0002909)2.03632744
107Advanced eruption of teeth (HP:0006288)2.03141913
108Brushfield spots (HP:0001088)2.02773830
109Enlarged kidneys (HP:0000105)2.02067290
110Right ventricular cardiomyopathy (HP:0011663)2.01879880
111Pancreatic islet-cell hyperplasia (HP:0004510)2.01714832
112Hemorrhage of the eye (HP:0011885)2.00791442
113Rickets (HP:0002748)1.98565905
114Abnormal enzyme/coenzyme activity (HP:0012379)1.97366525
115Abnormal tarsal ossification (HP:0008369)1.96361316
116Hypoplasia of the capital femoral epiphysis (HP:0003090)1.95773261
117Proximal placement of thumb (HP:0009623)1.95746790
118Bifid scrotum (HP:0000048)1.93275275
119Thrombophlebitis (HP:0004418)1.93063421
120Septate vagina (HP:0001153)1.92610449
121Abnormality of transition element cation homeostasis (HP:0011030)1.90991393
122Vomiting (HP:0002013)1.89145766
123Pterygium (HP:0001059)1.88003466
124Biconcave vertebral bodies (HP:0004586)1.87560885
125Hydroxyprolinuria (HP:0003080)1.86269415
126Abnormality of proline metabolism (HP:0010907)1.86269415
127Broad palm (HP:0001169)1.85757024
128Opisthotonus (HP:0002179)1.84985967
129Abnormality of the lacrimal duct (HP:0011481)1.84881847
130Abnormality of reticulocytes (HP:0004312)1.84766625
131Protrusio acetabuli (HP:0003179)1.83772653
132Abnormality of iron homeostasis (HP:0011031)1.83470825
133Abnormal delivery (HP:0001787)1.83192119
134Glycosuria (HP:0003076)1.82816200
135Abnormality of urine glucose concentration (HP:0011016)1.82816200
136Acute hepatic failure (HP:0006554)1.81969272
137Alkalosis (HP:0001948)1.78645233
138Achilles tendon contracture (HP:0001771)1.77734257
139Hypophosphatemic rickets (HP:0004912)1.77657956
140Heterotopia (HP:0002282)1.77605664
141Dysmetric saccades (HP:0000641)1.76467838
142Osteomalacia (HP:0002749)1.75087138
143Abnormality of oral frenula (HP:0000190)1.74191117
144Choanal stenosis (HP:0000452)1.73717766
145Premature rupture of membranes (HP:0001788)1.68899646
146Neonatal death (HP:0003811)1.68708835
147Abnormality of the lumbar spine (HP:0100712)1.66989141
148Nephroblastoma (Wilms tumor) (HP:0002667)1.65667265
149Wide nose (HP:0000445)1.64528517
150Hyperacusis (HP:0010780)1.64446824
151Abnormal hand bone ossification (HP:0010660)1.64106370
152Nasolacrimal duct obstruction (HP:0000579)1.63191293
153Alacrima (HP:0000522)1.63056664
154Arnold-Chiari malformation (HP:0002308)1.61542736
155Submucous cleft hard palate (HP:0000176)1.60364021
156Abnormality of the alveolar ridges (HP:0006477)1.60157989
157Diastasis recti (HP:0001540)1.57701179
158Abnormality of the acetabulum (HP:0003170)1.57668805
15911 pairs of ribs (HP:0000878)1.57632011
160Limited elbow extension (HP:0001377)1.57606946
161Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.57256438
162Absent epiphyses (HP:0010577)1.57256438

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.55354095
2ERN14.29607181
3SIK14.20256926
4FGFR43.82475515
5INSRR3.74405762
6EEF2K3.50308970
7TAOK33.35691909
8CDK123.24224440
9SMG13.04587195
10PKN22.94758370
11TRIB32.72838563
12ERBB42.53870695
13MST1R2.48051728
14PTK62.31928889
15LATS12.27906966
16WNK42.21258832
17MAP3K102.18666732
18FLT32.16655746
19FRK2.06352350
20PDK22.00368322
21MAP3K32.00048073
22MAPK111.80689398
23EPHA21.79987415
24MAP3K21.76658295
25MAPK151.59405371
26PTK21.52827788
27MET1.44967917
28CDC71.42861789
29TYRO31.38974375
30MAP2K41.36371566
31MAP2K21.35848884
32EIF2AK11.33662727
33TSSK61.30155169
34CAMK1G1.28174623
35ERBB21.27211326
36NEK91.24764414
37BUB11.22946745
38ABL21.20382985
39NEK21.20362921
40RIPK11.17935491
41CDK71.15925379
42TYK21.13999689
43NME21.11713838
44DYRK1B1.08139967
45PIK3CG1.07194491
46PAK41.03984214
47CDK61.03850365
48PDGFRA1.02623901
49KDR1.01973541
50JAK21.00689277
51BRSK21.00527372
52PRKAA20.99639186
53TTN0.98783242
54IRAK30.97940292
55MAP3K90.96266539
56KSR20.95660606
57NME10.95226030
58BRSK10.94275925
59GRK60.92755606
60WNK10.89679324
61MAP3K70.87323570
62SRPK10.86390356
63GSK3A0.84297017
64MAP3K110.83876272
65DAPK20.80835648
66STK38L0.80025304
67MAP2K10.79358013
68CHEK20.75888343
69BRD40.75612052
70EPHB20.74568586
71FGFR20.73360931
72MAP2K30.71575883
73PRKACG0.70970521
74MTOR0.70904116
75PASK0.68222016
76CHEK10.68169923
77PRKCZ0.65706348
78PRKG20.65568485
79PRKAA10.63647557
80MAPKAPK50.62463574
81CAMK1D0.59760621
82CDK10.59210962
83ICK0.57100533
84JAK10.56477839
85MAP3K10.55760457
86ALK0.55744252
87CDK40.55274098
88AURKB0.54548468
89CAMK2G0.54527334
90BMX0.54507496
91ATR0.54257960
92RPS6KB10.54081925
93PLK10.53168561
94AKT20.53051055
95TBK10.52699172
96CDK20.52574280
97BRAF0.51967764
98PLK30.51634620
99FER0.51205740
100STK30.50814496
101PAK30.50600174
102PRPF4B0.48717475
103IRAK20.48537112
104MAP2K60.48515215
105MKNK10.47297441
106CSK0.47247791
107MAPK40.45380923
108RAF10.45092896
109MAP3K80.44730322
110EPHB10.44179000
111YES10.43267706
112SIK20.42898764
113CAMKK10.42200602
114AURKA0.40667258
115ATM0.40300873
116PBK0.39867018
117CDK80.39038106
118SCYL20.38656359
119LMTK20.38250419
120WEE10.38013454
121RPS6KA10.37936943
122PIM20.37637471
123CLK10.37386355
124ARAF0.37099849
125IGF1R0.36035639
126RET0.35975767
127CSNK1G10.35869402
128PAK20.34994198
129FGFR10.32237578
130CSNK1E0.31994461
131MAPK140.31858208
132GSK3B0.31070894
133PRKDC0.30972053
134CSNK2A20.30687539
135EPHA30.30141972
136TTK0.29198314
137IRAK10.28630471
138TGFBR20.27507850
139LATS20.27273667
140PDPK10.27225047
141MAP3K140.25813997
142EGFR0.25613193
143HIPK20.25470353
144NEK10.23926964
145SGK30.22872327
146PRKCA0.22709127
147FGFR30.21969582
148CHUK0.21967309
149NTRK10.21483602
150RPS6KB20.20858592
151GRK10.19484314
152MAP3K50.19314711
153CSNK1A1L0.18669788
154MAPK30.17195935

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.13024722
2Nitrogen metabolism_Homo sapiens_hsa009103.91696845
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.52269451
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.25476164
5Arginine biosynthesis_Homo sapiens_hsa002203.04084695
6Tryptophan metabolism_Homo sapiens_hsa003802.68207650
7Complement and coagulation cascades_Homo sapiens_hsa046102.65750004
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.54397310
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.53521043
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.48013599
11Fatty acid degradation_Homo sapiens_hsa000712.41790462
12Pentose and glucuronate interconversions_Homo sapiens_hsa000402.29590528
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.23251610
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.10464865
15Butanoate metabolism_Homo sapiens_hsa006502.08991226
16Maturity onset diabetes of the young_Homo sapiens_hsa049502.06945398
17Histidine metabolism_Homo sapiens_hsa003401.89153995
18Chemical carcinogenesis_Homo sapiens_hsa052041.88156965
19Selenocompound metabolism_Homo sapiens_hsa004501.87366005
20Peroxisome_Homo sapiens_hsa041461.85094931
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.84924124
22Drug metabolism - other enzymes_Homo sapiens_hsa009831.75126444
23Steroid hormone biosynthesis_Homo sapiens_hsa001401.73374536
24Fatty acid metabolism_Homo sapiens_hsa012121.72943256
25PPAR signaling pathway_Homo sapiens_hsa033201.72092851
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.71651778
27Propanoate metabolism_Homo sapiens_hsa006401.70202171
28Sulfur metabolism_Homo sapiens_hsa009201.61152161
29Retinol metabolism_Homo sapiens_hsa008301.60729473
30beta-Alanine metabolism_Homo sapiens_hsa004101.57185334
31Steroid biosynthesis_Homo sapiens_hsa001001.54878772
32Staphylococcus aureus infection_Homo sapiens_hsa051501.54656764
33Bile secretion_Homo sapiens_hsa049761.54186967
34Caffeine metabolism_Homo sapiens_hsa002321.51026848
35Phenylalanine metabolism_Homo sapiens_hsa003601.50118264
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.47419588
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.44639375
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.42562949
39Fat digestion and absorption_Homo sapiens_hsa049751.41516187
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.41090888
41Pyruvate metabolism_Homo sapiens_hsa006201.38431651
42Starch and sucrose metabolism_Homo sapiens_hsa005001.37609730
43Biosynthesis of amino acids_Homo sapiens_hsa012301.33858651
44Tyrosine metabolism_Homo sapiens_hsa003501.33017019
45Other glycan degradation_Homo sapiens_hsa005111.29689489
46ABC transporters_Homo sapiens_hsa020101.28102858
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.27950136
48Folate biosynthesis_Homo sapiens_hsa007901.27738618
49DNA replication_Homo sapiens_hsa030301.21322726
50Carbon metabolism_Homo sapiens_hsa012001.20016909
51Fatty acid elongation_Homo sapiens_hsa000621.18167345
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.12903466
53Cyanoamino acid metabolism_Homo sapiens_hsa004601.07229813
54Arginine and proline metabolism_Homo sapiens_hsa003301.04281180
55One carbon pool by folate_Homo sapiens_hsa006700.98796468
56Vitamin B6 metabolism_Homo sapiens_hsa007500.96430891
57Lysine degradation_Homo sapiens_hsa003100.90801271
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.87053663
59Vitamin digestion and absorption_Homo sapiens_hsa049770.86904672
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.86447705
61Sulfur relay system_Homo sapiens_hsa041220.86079738
62Glutathione metabolism_Homo sapiens_hsa004800.80484893
63ECM-receptor interaction_Homo sapiens_hsa045120.79680781
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.79337842
65Thyroid cancer_Homo sapiens_hsa052160.74476789
66Pentose phosphate pathway_Homo sapiens_hsa000300.73093256
67Adherens junction_Homo sapiens_hsa045200.71632106
68Spliceosome_Homo sapiens_hsa030400.70328071
69Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.70135636
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.69157480
71RNA transport_Homo sapiens_hsa030130.68642893
72Cell cycle_Homo sapiens_hsa041100.68320723
73Glycerolipid metabolism_Homo sapiens_hsa005610.66801235
74mRNA surveillance pathway_Homo sapiens_hsa030150.66016098
75Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.64994926
76Small cell lung cancer_Homo sapiens_hsa052220.64549336
77Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.63047313
78Mismatch repair_Homo sapiens_hsa034300.58136943
79Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.53297052
80Fatty acid biosynthesis_Homo sapiens_hsa000610.46947439
81Nucleotide excision repair_Homo sapiens_hsa034200.46420257
82Metabolic pathways_Homo sapiens_hsa011000.44040361
83Galactose metabolism_Homo sapiens_hsa000520.42912470
84Base excision repair_Homo sapiens_hsa034100.42593190
85Fructose and mannose metabolism_Homo sapiens_hsa000510.39608111
86Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39455836
87MicroRNAs in cancer_Homo sapiens_hsa052060.35671398
88Sphingolipid metabolism_Homo sapiens_hsa006000.34358949
89Hippo signaling pathway_Homo sapiens_hsa043900.33713475
90Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.32166231
91Basal cell carcinoma_Homo sapiens_hsa052170.32078679
92Prion diseases_Homo sapiens_hsa050200.31801478
93Non-homologous end-joining_Homo sapiens_hsa034500.30729734
94Insulin resistance_Homo sapiens_hsa049310.30494457
95alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.23140194
96Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.21385491
97Glucagon signaling pathway_Homo sapiens_hsa049220.20780375
98Adipocytokine signaling pathway_Homo sapiens_hsa049200.17298923
99Linoleic acid metabolism_Homo sapiens_hsa005910.15037438
100Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.12966259
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.11934988
102AMPK signaling pathway_Homo sapiens_hsa041520.07038832
103Thyroid hormone synthesis_Homo sapiens_hsa049180.00744286
104Bladder cancer_Homo sapiens_hsa052190.00252627
105Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.2062070
106Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2021997
107Mineral absorption_Homo sapiens_hsa04978-0.1940157
108Protein digestion and absorption_Homo sapiens_hsa04974-0.1855372
109Protein export_Homo sapiens_hsa03060-0.1833407
110Hepatitis C_Homo sapiens_hsa05160-0.1767147
111Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.1534476
112Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1420071
113N-Glycan biosynthesis_Homo sapiens_hsa00510-0.1387000
114Type II diabetes mellitus_Homo sapiens_hsa04930-0.1299347
115Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1178656
116Renin-angiotensin system_Homo sapiens_hsa04614-0.1133950
117Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0829075
118Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0653272
119Insulin signaling pathway_Homo sapiens_hsa04910-0.0533714
120Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970-0.0340993
121Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0102300

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