PCNPP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1peptidyl-histidine modification (GO:0018202)5.23891369
2regulation of translational termination (GO:0006449)4.70097271
3ubiquinone metabolic process (GO:0006743)4.65909088
4protein-cofactor linkage (GO:0018065)4.65236159
5positive regulation of mitotic sister chromatid separation (GO:1901970)4.61206600
6positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.61206600
7positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.61206600
8kynurenine metabolic process (GO:0070189)4.49903319
9deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.48949329
10C4-dicarboxylate transport (GO:0015740)4.42298920
11acrosome reaction (GO:0007340)4.39353752
12establishment of integrated proviral latency (GO:0075713)4.37398284
13adaptation of signaling pathway (GO:0023058)4.35908744
14maternal behavior (GO:0042711)4.33860669
15regulation of mitotic spindle organization (GO:0060236)4.30695203
16regulation of translational fidelity (GO:0006450)4.09029298
17phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)4.05357561
18neuron remodeling (GO:0016322)4.04913087
19positive regulation of macroautophagy (GO:0016239)4.04435353
20mitochondrial RNA metabolic process (GO:0000959)3.94720570
21regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.89624368
22regulation of mitotic spindle checkpoint (GO:1903504)3.89624368
23ribosome assembly (GO:0042255)3.87936150
24parental behavior (GO:0060746)3.84539140
25righting reflex (GO:0060013)3.82582259
26alanine transport (GO:0032328)3.70013712
27regulation of alternative mRNA splicing, via spliceosome (GO:0000381)3.65456158
28positive regulation of response to extracellular stimulus (GO:0032106)3.64950709
29positive regulation of response to nutrient levels (GO:0032109)3.64950709
30rRNA modification (GO:0000154)3.59907845
31rRNA methylation (GO:0031167)3.57481244
32developmental pigmentation (GO:0048066)3.56116952
33glucosamine-containing compound catabolic process (GO:1901072)3.55810674
34regulation of type B pancreatic cell apoptotic process (GO:2000674)3.52487887
35tryptophan metabolic process (GO:0006568)3.51675174
36regulation of hexokinase activity (GO:1903299)3.50999283
37regulation of glucokinase activity (GO:0033131)3.50999283
38protein complex biogenesis (GO:0070271)3.50594009
39establishment of viral latency (GO:0019043)3.40255128
40fusion of sperm to egg plasma membrane (GO:0007342)3.38883372
41fatty acid elongation (GO:0030497)3.38756271
42endosome to melanosome transport (GO:0035646)3.37621897
43endosome to pigment granule transport (GO:0043485)3.37621897
44embryonic placenta development (GO:0001892)3.27991464
45proline biosynthetic process (GO:0006561)3.27119008
46respiratory chain complex IV assembly (GO:0008535)3.25348413
47negative regulation of JAK-STAT cascade (GO:0046426)3.22155952
48lens fiber cell differentiation (GO:0070306)3.19990395
49mitochondrial respiratory chain complex assembly (GO:0033108)3.19529537
50mitochondrial calcium ion transport (GO:0006851)3.18788353
51intestinal epithelial cell development (GO:0060576)3.17717398
52coenzyme A metabolic process (GO:0015936)3.13933966
53folic acid-containing compound biosynthetic process (GO:0009396)3.12792302
54regulation of metalloenzyme activity (GO:0048552)3.12751748
55regulation of translational elongation (GO:0006448)3.10882964
56tryptophan catabolic process (GO:0006569)3.07187923
57indole-containing compound catabolic process (GO:0042436)3.07187923
58indolalkylamine catabolic process (GO:0046218)3.07187923
59isoprenoid biosynthetic process (GO:0008299)3.06518133
60sperm-egg recognition (GO:0035036)3.03072367
61protein peptidyl-prolyl isomerization (GO:0000413)3.01799868
62negative regulation of striated muscle cell apoptotic process (GO:0010664)2.99419646
63cytochrome complex assembly (GO:0017004)2.99393321
64binding of sperm to zona pellucida (GO:0007339)2.97187225
65fructose metabolic process (GO:0006000)2.95602253
66ribosomal large subunit biogenesis (GO:0042273)2.95111921
67endoderm development (GO:0007492)2.95060375
68positive regulation of muscle cell apoptotic process (GO:0010661)2.94441517
69regulation of spindle checkpoint (GO:0090231)2.92961947
70cellular response to zinc ion (GO:0071294)2.92294707
71aggressive behavior (GO:0002118)2.91626136
72platelet dense granule organization (GO:0060155)2.90797212
73seminiferous tubule development (GO:0072520)2.90697474
74regulation of penile erection (GO:0060405)2.83048515
75regulation of meiosis I (GO:0060631)2.82047375
76establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.77101069
77mitochondrion transport along microtubule (GO:0047497)2.77101069
78regulation of mRNA splicing, via spliceosome (GO:0048024)2.75747473
79purine-containing compound salvage (GO:0043101)2.74666426
80positive regulation of chromosome segregation (GO:0051984)2.73416398
81mitochondrial calcium ion homeostasis (GO:0051560)2.73265839
82cellular response to dsRNA (GO:0071359)2.69727162
83tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.68966462
84RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.68966462
85transcription from mitochondrial promoter (GO:0006390)2.67134300
86positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.66339502
87negative regulation of viral release from host cell (GO:1902187)2.65163038
88positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.64709218
89L-alpha-amino acid transmembrane transport (GO:1902475)2.64613220
90negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.63991409
91regulation of histone phosphorylation (GO:0033127)2.63206763
92positive regulation of skeletal muscle tissue development (GO:0048643)2.62559970
93de novo protein folding (GO:0006458)2.62473128
94antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.62431857
95negative regulation of insulin secretion (GO:0046676)2.62404824
96indolalkylamine metabolic process (GO:0006586)2.62319466
97regulation of pigment cell differentiation (GO:0050932)2.60747761
98pyrimidine nucleoside salvage (GO:0043097)2.60708871
99pyrimidine-containing compound salvage (GO:0008655)2.60708871
100magnesium ion transport (GO:0015693)2.59547016

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.91329536
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.29587627
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.91985155
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.39667860
5ETS1_20019798_ChIP-Seq_JURKAT_Human3.24053780
6ELK1_19687146_ChIP-ChIP_HELA_Human3.17905121
7CREB1_15753290_ChIP-ChIP_HEK293T_Human2.99357342
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.87532022
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.86471931
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.86303177
11TFEB_21752829_ChIP-Seq_HELA_Human2.71925086
12DCP1A_22483619_ChIP-Seq_HELA_Human2.71520189
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.71160689
14ZNF274_21170338_ChIP-Seq_K562_Hela2.59380085
15SMAD_19615063_ChIP-ChIP_OVARY_Human2.51987074
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.44513093
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.40842196
18VDR_23849224_ChIP-Seq_CD4+_Human2.36535726
19SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.31598314
20ZNF263_19887448_ChIP-Seq_K562_Human2.16706311
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.11434742
22FOXP3_21729870_ChIP-Seq_TREG_Human2.01343826
23MYC_18555785_ChIP-Seq_MESCs_Mouse1.85340228
24MYC_18358816_ChIP-ChIP_MESCs_Mouse1.83615910
25ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.83494233
26SRF_21415370_ChIP-Seq_HL-1_Mouse1.80195691
27SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.79953868
28EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.76267117
29SALL1_21062744_ChIP-ChIP_HESCs_Human1.74449390
30ELK1_22589737_ChIP-Seq_MCF10A_Human1.67863144
31IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.66867675
32FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.66202618
33MYC_18940864_ChIP-ChIP_HL60_Human1.63892290
34GABP_19822575_ChIP-Seq_HepG2_Human1.62218013
35NOTCH1_21737748_ChIP-Seq_TLL_Human1.62056402
36E2F1_18555785_ChIP-Seq_MESCs_Mouse1.61982544
37EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.46561247
38LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.44946893
39CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.44415298
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.42475354
41VDR_22108803_ChIP-Seq_LS180_Human1.41910600
42PADI4_21655091_ChIP-ChIP_MCF-7_Human1.40858529
43PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.40501695
44FOXA1_27270436_Chip-Seq_PROSTATE_Human1.39140911
45FOXA1_25329375_ChIP-Seq_VCAP_Human1.39140911
46NELFA_20434984_ChIP-Seq_ESCs_Mouse1.37853467
47HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.37146251
48FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.36207136
49PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.33946812
50FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.32837006
51CTCF_18555785_ChIP-Seq_MESCs_Mouse1.31430215
52MYC_19030024_ChIP-ChIP_MESCs_Mouse1.31258852
53PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.29574578
54CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.29129220
55YY1_21170310_ChIP-Seq_MESCs_Mouse1.26204819
56TTF2_22483619_ChIP-Seq_HELA_Human1.25530109
57FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.24264462
58MYC_19079543_ChIP-ChIP_MESCs_Mouse1.18856828
59FUS_26573619_Chip-Seq_HEK293_Human1.17517496
60ELF5_23300383_ChIP-Seq_T47D_Human1.15670446
61AUTS2_25519132_ChIP-Seq_293T-REX_Human1.14920248
62SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.14357082
63JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11024141
64POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.10277139
65MYCN_18555785_ChIP-Seq_MESCs_Mouse1.09725738
66MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.08550049
67NCOR_22424771_ChIP-Seq_293T_Human1.07194674
68ZFX_18555785_ChIP-Seq_MESCs_Mouse0.98592321
69MYB_26560356_Chip-Seq_TH2_Human0.98345047
70PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.97822001
71EWS_26573619_Chip-Seq_HEK293_Human0.96888856
72IRF8_21731497_ChIP-ChIP_J774_Mouse0.95650944
73CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.94171729
74ER_23166858_ChIP-Seq_MCF-7_Human0.93997911
75STAT1_20625510_ChIP-Seq_HELA_Human0.93689139
76IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.93085832
77GATA3_26560356_Chip-Seq_TH2_Human0.92798415
78PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.92249424
79PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.88747042
80GATA1_19941826_ChIP-Seq_K562_Human0.86468379
81TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.85394445
82FOXH1_21741376_ChIP-Seq_EPCs_Human0.83068796
83RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.82735141
84FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.81678841
85MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.80047806
86TAF2_19829295_ChIP-Seq_ESCs_Human0.79336275
87SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.79083721
88STAT4_19710469_ChIP-ChIP_TH1__Mouse0.78969053
89JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78450249
90LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.78108549
91NANOG_16153702_ChIP-ChIP_HESCs_Human0.77734737
92CTBP2_25329375_ChIP-Seq_LNCAP_Human0.77016423
93TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.75933030
94ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.75702324
95CTBP1_25329375_ChIP-Seq_LNCAP_Human0.74674332
96HTT_18923047_ChIP-ChIP_STHdh_Human0.73270836
97PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.72149996
98STAT3_1855785_ChIP-Seq_MESCs_Mouse0.71470721
99EOMES_21245162_ChIP-Seq_HESCs_Human0.71250245
100XRN2_22483619_ChIP-Seq_HELA_Human0.71049454

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation9.18336152
2MP0005409_darkened_coat_color5.67735661
3MP0001188_hyperpigmentation4.10978142
4MP0002138_abnormal_hepatobiliary_system4.06388967
5MP0005174_abnormal_tail_pigmentation3.46928862
6MP0003303_peritoneal_inflammation3.35548183
7MP0002102_abnormal_ear_morphology3.25604883
8MP0000015_abnormal_ear_pigmentation3.23571819
9MP0002837_dystrophic_cardiac_calcinosis3.09768963
10MP0008007_abnormal_cellular_replicative2.97046363
11MP0001542_abnormal_bone_strength2.50797398
12MP0005187_abnormal_penis_morphology2.46515885
13MP0008057_abnormal_DNA_replication2.34463028
14MP0005410_abnormal_fertilization2.22870177
15MP0003646_muscle_fatigue2.20070625
16MP0000647_abnormal_sebaceous_gland2.06842249
17MP0009697_abnormal_copulation2.04332833
18MP0005464_abnormal_platelet_physiology1.99780346
19MP0005084_abnormal_gallbladder_morpholo1.96400708
20MP0003283_abnormal_digestive_organ1.82787445
21MP0009840_abnormal_foam_cell1.73783402
22MP0002095_abnormal_skin_pigmentation1.68204854
23MP0002638_abnormal_pupillary_reflex1.62216508
24MP0003252_abnormal_bile_duct1.57078616
25MP0009785_altered_susceptibility_to1.51392807
26MP0004510_myositis1.49679480
27MP0002693_abnormal_pancreas_physiology1.42657071
28MP0005058_abnormal_lysosome_morphology1.41784157
29MP0008058_abnormal_DNA_repair1.41436005
30MP0000383_abnormal_hair_follicle1.37422108
31MP0001968_abnormal_touch/_nociception1.27697200
32MP0001986_abnormal_taste_sensitivity1.21791442
33MP0001243_abnormal_dermal_layer1.18774107
34MP0010678_abnormal_skin_adnexa1.17387698
35MP0000372_irregular_coat_pigmentation1.17128984
36MP0003111_abnormal_nucleus_morphology1.16266369
37MP0002269_muscular_atrophy1.15393272
38MP0000604_amyloidosis1.12430641
39MP0003786_premature_aging1.10629819
40MP0005171_absent_coat_pigmentation1.09947377
41MP0002928_abnormal_bile_duct1.08009650
42MP0006036_abnormal_mitochondrial_physio1.05334979
43MP0009333_abnormal_splenocyte_physiolog1.03439481
44MP0005636_abnormal_mineral_homeostasis0.97846206
45MP0002282_abnormal_trachea_morphology0.96732760
46MP0002139_abnormal_hepatobiliary_system0.95865541
47MP0002736_abnormal_nociception_after0.95434174
48MP0000613_abnormal_salivary_gland0.93845431
49MP0003075_altered_response_to0.92968780
50MP0002148_abnormal_hypersensitivity_rea0.92088004
51MP0005165_increased_susceptibility_to0.85349866
52MP0002177_abnormal_outer_ear0.84017282
53MP0005266_abnormal_metabolism0.83804064
54MP0003195_calcinosis0.83168483
55MP0003806_abnormal_nucleotide_metabolis0.80611890
56MP0005166_decreased_susceptibility_to0.78426873
57MP0003718_maternal_effect0.77484997
58MP0001661_extended_life_span0.73902156
59MP0003448_altered_tumor_morphology0.73223451
60MP0001845_abnormal_inflammatory_respons0.71915491
61MP0002332_abnormal_exercise_endurance0.68706903
62MP0002127_abnormal_cardiovascular_syste0.66843808
63MP0003186_abnormal_redox_activity0.66092211
64MP0000343_altered_response_to0.64758213
65MP0005595_abnormal_vascular_smooth0.64230952
66MP0002106_abnormal_muscle_physiology0.63688093
67MP0006035_abnormal_mitochondrial_morpho0.62951790
68MP0008260_abnormal_autophagy0.62581977
69MP0000750_abnormal_muscle_regeneration0.60863091
70MP0001905_abnormal_dopamine_level0.60319712
71MP0002733_abnormal_thermal_nociception0.58723357
72MP0002163_abnormal_gland_morphology0.58229596
73MP0002405_respiratory_system_inflammati0.57699459
74MP0008872_abnormal_physiological_respon0.56457572
75MP0008873_increased_physiological_sensi0.56228925
76MP0008469_abnormal_protein_level0.56226760
77MP0002098_abnormal_vibrissa_morphology0.55637197
78MP0005623_abnormal_meninges_morphology0.55588986
79MP0010386_abnormal_urinary_bladder0.55123079
80MP0005395_other_phenotype0.52827917
81MP0001765_abnormal_ion_homeostasis0.52661296
82MP0003279_aneurysm0.52620218
83MP0001944_abnormal_pancreas_morphology0.52557389
84MP0005367_renal/urinary_system_phenotyp0.51639551
85MP0000516_abnormal_urinary_system0.51639551
86MP0001730_embryonic_growth_arrest0.50154311
87MP0004957_abnormal_blastocyst_morpholog0.49669626
88MP0003795_abnormal_bone_structure0.49451671
89MP0000230_abnormal_systemic_arterial0.49065134
90MP0005671_abnormal_response_to0.48904159
91MP0000467_abnormal_esophagus_morphology0.48793654
92MP0002019_abnormal_tumor_incidence0.48454330
93MP0002938_white_spotting0.48198211
94MP0005330_cardiomyopathy0.47726271
95MP0001348_abnormal_lacrimal_gland0.47452284
96MP0006072_abnormal_retinal_apoptosis0.45973162
97MP0002877_abnormal_melanocyte_morpholog0.44779651
98MP0010771_integument_phenotype0.44485723
99MP0003941_abnormal_skin_development0.43569237
100MP0005164_abnormal_response_to0.43013187

Predicted human phenotypes

RankGene SetZ-score
1Decreased activity of mitochondrial respiratory chain (HP:0008972)4.05693160
2Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.05693160
3Fibular aplasia (HP:0002990)3.86989249
4Ependymoma (HP:0002888)3.72552094
5Choroideremia (HP:0001139)3.70694984
6Hypoglycemic seizures (HP:0002173)3.62470351
7Facial hemangioma (HP:0000329)3.57922796
8Buphthalmos (HP:0000557)3.52229785
9Increased intramyocellular lipid droplets (HP:0012240)3.47661609
10Methylmalonic acidemia (HP:0002912)3.43826465
11Hepatocellular necrosis (HP:0001404)3.39919402
12Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.34713783
13Hypothermia (HP:0002045)3.25796807
14Conjunctival telangiectasia (HP:0000524)3.24856611
15Congenital glaucoma (HP:0001087)3.12544082
16Reduced antithrombin III activity (HP:0001976)3.07091236
17Abnormality of the costochondral junction (HP:0000919)3.07018632
18Medulloblastoma (HP:0002885)3.05312945
19Limb-girdle muscle atrophy (HP:0003797)2.98542040
20Vacuolated lymphocytes (HP:0001922)2.97555332
21Large for gestational age (HP:0001520)2.95077901
22Astrocytoma (HP:0009592)2.92598907
23Abnormality of the astrocytes (HP:0100707)2.92598907
24Hyperinsulinemic hypoglycemia (HP:0000825)2.90951077
25Symptomatic seizures (HP:0011145)2.90545611
26Hepatic necrosis (HP:0002605)2.89835763
27Cortical dysplasia (HP:0002539)2.87219410
28Distal lower limb amyotrophy (HP:0008944)2.85773223
29Type I transferrin isoform profile (HP:0003642)2.85089773
30Late onset (HP:0003584)2.84518229
31Type I diabetes mellitus (HP:0100651)2.80497820
32Aplasia cutis congenita (HP:0001057)2.77092925
33Hypoglycemic coma (HP:0001325)2.75501810
34Metaphyseal dysplasia (HP:0100255)2.72825644
35Increased muscle lipid content (HP:0009058)2.72565342
36Lower limb hyperreflexia (HP:0002395)2.70042964
37Beaking of vertebral bodies (HP:0004568)2.69648277
38Ketoacidosis (HP:0001993)2.68374405
39Rhabdomyosarcoma (HP:0002859)2.64820356
40Abnormal pupillary function (HP:0007686)2.58626158
41Abnormal mitochondria in muscle tissue (HP:0008316)2.57347751
42Autoamputation (HP:0001218)2.53169078
43Abnormality of the vasculature of the conjunctiva (HP:0008054)2.52350503
44Abnormality of endocrine pancreas physiology (HP:0012093)2.50440160
45Abnormality of the pancreatic islet cells (HP:0006476)2.50440160
46Exocrine pancreatic insufficiency (HP:0001738)2.49953046
47Increased CSF lactate (HP:0002490)2.48118672
48Lower limb amyotrophy (HP:0007210)2.41051595
49Brushfield spots (HP:0001088)2.38224973
50Mitochondrial inheritance (HP:0001427)2.37723299
51Spastic paraparesis (HP:0002313)2.36632954
52Insulin-resistant diabetes mellitus (HP:0000831)2.35564808
53Abnormal gallbladder physiology (HP:0012438)2.33853247
54Cholecystitis (HP:0001082)2.33853247
55Neoplasm of striated muscle (HP:0009728)2.33584493
56Hyperglycemia (HP:0003074)2.29464348
573-Methylglutaconic aciduria (HP:0003535)2.28619016
58Increased hepatocellular lipid droplets (HP:0006565)2.26903722
59Onycholysis (HP:0001806)2.25561010
60Methylmalonic aciduria (HP:0012120)2.21976638
61Zonular cataract (HP:0010920)2.16326648
62Glioma (HP:0009733)2.14414607
63Chronic diarrhea (HP:0002028)2.13318476
64Acute necrotizing encephalopathy (HP:0006965)2.10532967
65Heterochromia iridis (HP:0001100)2.07721045
66Insulin resistance (HP:0000855)2.07480062
67Corneal dystrophy (HP:0001131)2.05937915
68Upper limb muscle weakness (HP:0003484)2.01989953
69Osteolytic defects of the phalanges of the hand (HP:0009771)1.99440934
70Osteolytic defects of the hand bones (HP:0009699)1.99440934
71Respiratory failure (HP:0002878)1.98321074
72Tongue fasciculations (HP:0001308)1.96920794
73Chronic bronchitis (HP:0004469)1.96055337
74Steatorrhea (HP:0002570)1.95239893
75Lipid accumulation in hepatocytes (HP:0006561)1.93839331
76Progressive macrocephaly (HP:0004481)1.93831797
77Dyskinesia (HP:0100660)1.93551729
78Abnormal trabecular bone morphology (HP:0100671)1.92579435
79Delayed closure of the anterior fontanelle (HP:0001476)1.91876591
80Rough bone trabeculation (HP:0100670)1.91224551
81Renal cortical cysts (HP:0000803)1.91153319
82Aplasia/Hypoplasia of the fovea (HP:0008060)1.90784688
83Hypoplasia of the fovea (HP:0007750)1.90784688
84Abnormality of subcutaneous fat tissue (HP:0001001)1.89097824
85Hamartoma of the eye (HP:0010568)1.87475409
86Porencephaly (HP:0002132)1.87380141
87Palpitations (HP:0001962)1.87307105
88Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.86347534
89Abnormal protein N-linked glycosylation (HP:0012347)1.86347534
90Abnormal protein glycosylation (HP:0012346)1.86347534
91Abnormal glycosylation (HP:0012345)1.86347534
92Adrenal hypoplasia (HP:0000835)1.83999441
93Termporal pattern (HP:0011008)1.83842057
94Insidious onset (HP:0003587)1.83842057
95Abnormality of liposaccharide metabolism (HP:0010968)1.82361385
96Abnormality of glycosphingolipid metabolism (HP:0004343)1.82361385
97Abnormality of glycolipid metabolism (HP:0010969)1.82361385
98Neoplasm of the adrenal cortex (HP:0100641)1.82319252
99Synostosis involving the elbow (HP:0003938)1.82229138
100Humeroradial synostosis (HP:0003041)1.82229138

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PINK15.93152547
2BUB14.55126440
3SCYL23.67066286
4IRAK33.18457307
5CDC73.00241119
6MST42.86108101
7LIMK12.77518923
8TESK12.54168064
9EPHA22.44719123
10NEK12.40611978
11MAP4K22.26047613
12EIF2AK12.23358678
13TRIM282.20841900
14MAPKAPK32.06085466
15STK161.91641497
16TESK21.89709662
17STK241.81259098
18NME21.73718343
19PASK1.55677973
20ERBB41.43290028
21STK38L1.39579056
22CSNK1G31.28419560
23MAP2K61.27397355
24ERBB31.24841019
25SRPK11.23443189
26JAK31.21814278
27MINK11.21757632
28CSNK1G11.21650475
29MST1R1.16465230
30FRK1.15526842
31DAPK11.08042944
32TRPM71.06319841
33PAK41.03877161
34MAP3K91.03793211
35CSNK1A1L1.00342865
36STK30.98615255
37TSSK60.97230965
38GRK10.96300407
39RPS6KA40.95394787
40ADRBK20.92241044
41LMTK20.91475124
42PIM20.88531974
43PRKD30.87221034
44CDK60.84526007
45ATR0.79207702
46MAP3K80.79102266
47STK100.77809914
48MAP3K120.74723711
49CSNK1G20.74693023
50PLK20.70163985
51PAK60.69832115
52PHKG10.69084934
53PHKG20.69084934
54GSK3A0.68571769
55PLK30.65892681
56TTK0.62808853
57DAPK20.59894443
58MAP3K30.58494835
59VRK20.58492366
60PRKD20.55556991
61EIF2AK30.55251085
62MAP2K70.54529686
63KDR0.54448951
64ADRBK10.50947993
65STK390.50581119
66IKBKB0.47436244
67PLK40.47019526
68IGF1R0.45037972
69CAMK2G0.42796971
70WNK30.41851423
71ROCK20.41363356
72WEE10.41020349
73IRAK20.40953565
74WNK40.39089490
75ROCK10.38869259
76CLK10.37716110
77ABL20.37580049
78PTK2B0.37109678
79NTRK30.36718190
80INSRR0.35711624
81EGFR0.35696574
82PRKCI0.35335818
83ALK0.35247693
84CAMK2A0.35012695
85ABL10.34815170
86BCKDK0.34625117
87CSNK1A10.34398827
88MYLK0.33049228
89FLT30.32821737
90AURKA0.31873825
91FGFR30.31640471
92LRRK20.31368765
93PAK10.27779318
94MKNK10.26797235
95TAOK20.25812205
96MAPK110.25204358
97DAPK30.25121946
98LATS10.24965586
99GRK70.24749936
100NUAK10.24216340

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.98452618
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.80132136
3Maturity onset diabetes of the young_Homo sapiens_hsa049503.59577267
4Protein export_Homo sapiens_hsa030603.32504874
5Oxidative phosphorylation_Homo sapiens_hsa001902.84819076
6Sulfur metabolism_Homo sapiens_hsa009202.83462514
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.60682998
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.40902328
9One carbon pool by folate_Homo sapiens_hsa006702.35175163
10Collecting duct acid secretion_Homo sapiens_hsa049662.27788262
11Mismatch repair_Homo sapiens_hsa034302.21331158
12Vibrio cholerae infection_Homo sapiens_hsa051102.20325208
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.07003020
14African trypanosomiasis_Homo sapiens_hsa051431.94399995
15Renin secretion_Homo sapiens_hsa049241.93889153
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.87671280
17Parkinsons disease_Homo sapiens_hsa050121.82387214
18Rheumatoid arthritis_Homo sapiens_hsa053231.79112656
19Selenocompound metabolism_Homo sapiens_hsa004501.73283635
20RNA polymerase_Homo sapiens_hsa030201.65127679
21Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.47795673
22DNA replication_Homo sapiens_hsa030301.47362917
23Primary bile acid biosynthesis_Homo sapiens_hsa001201.46751471
24Purine metabolism_Homo sapiens_hsa002301.41444859
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.38728165
26Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.38038573
27Fatty acid elongation_Homo sapiens_hsa000621.35237622
28Pyrimidine metabolism_Homo sapiens_hsa002401.29523022
29Alzheimers disease_Homo sapiens_hsa050101.23576630
30Antigen processing and presentation_Homo sapiens_hsa046121.23182512
31Type II diabetes mellitus_Homo sapiens_hsa049301.17829132
32Tryptophan metabolism_Homo sapiens_hsa003801.15876703
33Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.13859994
34Vitamin B6 metabolism_Homo sapiens_hsa007501.08216743
35Nitrogen metabolism_Homo sapiens_hsa009101.07382282
36Salivary secretion_Homo sapiens_hsa049701.05102842
37Huntingtons disease_Homo sapiens_hsa050161.03326630
38Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.98126699
39RNA transport_Homo sapiens_hsa030130.97433752
40Glutathione metabolism_Homo sapiens_hsa004800.97416380
41Fructose and mannose metabolism_Homo sapiens_hsa000510.92086613
42Tyrosine metabolism_Homo sapiens_hsa003500.89817259
43Phototransduction_Homo sapiens_hsa047440.89259329
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.84815612
45Type I diabetes mellitus_Homo sapiens_hsa049400.83743153
46Legionellosis_Homo sapiens_hsa051340.83405065
47Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.82979505
48Biosynthesis of amino acids_Homo sapiens_hsa012300.82698027
49Arginine and proline metabolism_Homo sapiens_hsa003300.81367058
50Synaptic vesicle cycle_Homo sapiens_hsa047210.79956520
51Butanoate metabolism_Homo sapiens_hsa006500.75385054
52Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.73947756
53Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.73915320
54Galactose metabolism_Homo sapiens_hsa000520.73312431
55Pyruvate metabolism_Homo sapiens_hsa006200.71562004
56Ribosome_Homo sapiens_hsa030100.70742086
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.70511681
58RNA degradation_Homo sapiens_hsa030180.64701260
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64549646
60Peroxisome_Homo sapiens_hsa041460.63012981
61Lysosome_Homo sapiens_hsa041420.62163364
62Starch and sucrose metabolism_Homo sapiens_hsa005000.62031042
63NF-kappa B signaling pathway_Homo sapiens_hsa040640.61833088
64Primary immunodeficiency_Homo sapiens_hsa053400.61276287
65Folate biosynthesis_Homo sapiens_hsa007900.61136628
66Homologous recombination_Homo sapiens_hsa034400.58608364
67Arginine biosynthesis_Homo sapiens_hsa002200.55582026
68Mineral absorption_Homo sapiens_hsa049780.54918828
69Insulin secretion_Homo sapiens_hsa049110.52617567
70Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.52390385
71Metabolic pathways_Homo sapiens_hsa011000.52226887
72N-Glycan biosynthesis_Homo sapiens_hsa005100.51713695
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.50343889
74Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50295813
75Hematopoietic cell lineage_Homo sapiens_hsa046400.49530263
76Cysteine and methionine metabolism_Homo sapiens_hsa002700.47205629
77Malaria_Homo sapiens_hsa051440.46950624
78Basal transcription factors_Homo sapiens_hsa030220.46859397
79Graft-versus-host disease_Homo sapiens_hsa053320.44447237
80Propanoate metabolism_Homo sapiens_hsa006400.43762584
81Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.43537383
82mRNA surveillance pathway_Homo sapiens_hsa030150.41688678
83Cardiac muscle contraction_Homo sapiens_hsa042600.41272053
84Fatty acid degradation_Homo sapiens_hsa000710.39460837
85Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.36466677
86Circadian entrainment_Homo sapiens_hsa047130.36320577
87Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.34413169
88Nucleotide excision repair_Homo sapiens_hsa034200.33965174
89Olfactory transduction_Homo sapiens_hsa047400.29231942
90Amoebiasis_Homo sapiens_hsa051460.28611243
91Steroid biosynthesis_Homo sapiens_hsa001000.28167645
92Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.26253353
93Carbon metabolism_Homo sapiens_hsa012000.25158655
94Base excision repair_Homo sapiens_hsa034100.24419769
95Thyroid hormone synthesis_Homo sapiens_hsa049180.24298484
96Bile secretion_Homo sapiens_hsa049760.22639493
97TNF signaling pathway_Homo sapiens_hsa046680.22433582
98Sphingolipid metabolism_Homo sapiens_hsa006000.22324342
99Salmonella infection_Homo sapiens_hsa051320.20718529
100Viral myocarditis_Homo sapiens_hsa054160.20641272

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