PCNPP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sex differentiation (GO:0007548)8.09680255
2negative regulation of type 2 immune response (GO:0002829)7.92596372
3positive regulation of uterine smooth muscle contraction (GO:0070474)7.90393364
4tachykinin receptor signaling pathway (GO:0007217)7.41130013
5regulation of establishment of cell polarity (GO:2000114)7.06729155
6activation of MAPKKK activity (GO:0000185)6.94682956
7alternative mRNA splicing, via spliceosome (GO:0000380)6.88207644
8cytoplasmic mRNA processing body assembly (GO:0033962)6.86585896
9regulation of MHC class I biosynthetic process (GO:0045343)6.70957183
10negative regulation of multicellular organism growth (GO:0040015)6.67945396
11regulation of uterine smooth muscle contraction (GO:0070472)5.85657701
12hyperosmotic salinity response (GO:0042538)5.75058589
13sterol catabolic process (GO:0016127)5.71284994
14cholesterol catabolic process (GO:0006707)5.71284994
15regulation of metalloenzyme activity (GO:0048552)5.70454962
16regulation of establishment or maintenance of cell polarity (GO:0032878)5.67384074
17cerebellar Purkinje cell differentiation (GO:0021702)5.58940738
18synaptic transmission, cholinergic (GO:0007271)5.41730026
19stress granule assembly (GO:0034063)5.41407646
20primary amino compound metabolic process (GO:1901160)5.39862480
21regulation of dopamine metabolic process (GO:0042053)5.17255043
22regulation of catecholamine metabolic process (GO:0042069)5.17255043
23negative regulation of retinoic acid receptor signaling pathway (GO:0048387)5.14090640
24G-protein coupled glutamate receptor signaling pathway (GO:0007216)5.05339295
25positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)5.01020685
26regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)5.01020685
27serotonin metabolic process (GO:0042428)4.97077018
28chaperone-mediated protein complex assembly (GO:0051131)4.88283416
29kynurenine metabolic process (GO:0070189)4.71110633
30positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO4.69079655
31regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)4.69079655
32RNA destabilization (GO:0050779)4.68093276
33positive regulation of vasculogenesis (GO:2001214)4.65407795
34tryptophan metabolic process (GO:0006568)4.63190145
35regulation of interleukin-13 production (GO:0032656)4.48629841
36regulation of glucocorticoid secretion (GO:2000849)4.17036334
37regulation of retinoic acid receptor signaling pathway (GO:0048385)4.16984813
38behavioral response to nicotine (GO:0035095)4.09974053
39negative regulation of interleukin-1 beta production (GO:0032691)4.05521944
40negative regulation of receptor-mediated endocytosis (GO:0048261)3.96506876
41ADP metabolic process (GO:0046031)3.95480024
42central nervous system projection neuron axonogenesis (GO:0021952)3.90797014
43positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)3.81713480
44dopamine biosynthetic process (GO:0042416)3.81649929
45regulation of feeding behavior (GO:0060259)3.80669584
46indole-containing compound catabolic process (GO:0042436)3.77857613
47indolalkylamine catabolic process (GO:0046218)3.77857613
48tryptophan catabolic process (GO:0006569)3.77857613
49regulation of interleukin-5 production (GO:0032674)3.74727607
50positive regulation of mRNA catabolic process (GO:0061014)3.68708840
51positive regulation of mRNA 3-end processing (GO:0031442)3.68456343
52neuronal action potential propagation (GO:0019227)3.67952603
53lipid particle organization (GO:0034389)3.66905456
54indole-containing compound metabolic process (GO:0042430)3.54434437
55catecholamine biosynthetic process (GO:0042423)3.52240007
56catechol-containing compound biosynthetic process (GO:0009713)3.52240007
57regulation of vasculogenesis (GO:2001212)3.51618010
58negative regulation of interleukin-1 production (GO:0032692)3.51122596
59dopamine transport (GO:0015872)3.49428133
60embryonic hemopoiesis (GO:0035162)3.49149991
61fucose catabolic process (GO:0019317)3.47096624
62L-fucose metabolic process (GO:0042354)3.47096624
63L-fucose catabolic process (GO:0042355)3.47096624
64positive regulation of dendritic spine morphogenesis (GO:0061003)3.41335499
65short-term memory (GO:0007614)3.37448729
66NAD biosynthetic process (GO:0009435)3.34665156
67negative regulation of endothelial cell apoptotic process (GO:2000352)3.33335435
68positive regulation of dendritic spine development (GO:0060999)3.33263604
69regulation of corticosteroid hormone secretion (GO:2000846)3.31153849
70seminiferous tubule development (GO:0072520)3.29296882
71negative regulation of endothelial cell proliferation (GO:0001937)3.26538840
72central nervous system neuron axonogenesis (GO:0021955)3.23995219
73regulation of mRNA catabolic process (GO:0061013)3.19618950
74negative regulation of mast cell activation (GO:0033004)3.18698729
75negative regulation of calcium ion transport into cytosol (GO:0010523)3.17266949
76L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.12646240
77glycerophospholipid catabolic process (GO:0046475)3.09629594
78negative regulation of macroautophagy (GO:0016242)3.07218584
79steroid catabolic process (GO:0006706)3.05258324
80phosphatidylglycerol biosynthetic process (GO:0006655)3.02144975
81response to cocaine (GO:0042220)3.01571202
82peptidyl-threonine dephosphorylation (GO:0035970)3.01354616
83indolalkylamine metabolic process (GO:0006586)3.01203855
84nucleoside diphosphate catabolic process (GO:0009134)2.98191142
85positive regulation of heart rate (GO:0010460)2.97388204
86histone H3-K4 trimethylation (GO:0080182)2.94418596
87regulation of mRNA 3-end processing (GO:0031440)2.93020514
88negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.91632166
89bile acid biosynthetic process (GO:0006699)2.88094375
90regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.82664246
91regulation of translational elongation (GO:0006448)2.79823716
92amino acid salvage (GO:0043102)2.74121947
93L-methionine salvage (GO:0071267)2.74121947
94L-methionine biosynthetic process (GO:0071265)2.74121947
95protein autoprocessing (GO:0016540)2.70771329
96lipid translocation (GO:0034204)2.70613728
97phospholipid translocation (GO:0045332)2.70613728
98regulation of gene silencing by miRNA (GO:0060964)2.70020943
99adaptation of signaling pathway (GO:0023058)13.8200263
100regulation of memory T cell differentiation (GO:0043380)10.1822620

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse6.52769049
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.94148507
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse5.07968727
4VDR_22108803_ChIP-Seq_LS180_Human4.16599771
5SALL1_21062744_ChIP-ChIP_HESCs_Human4.09624090
6TAF15_26573619_Chip-Seq_HEK293_Human3.29862520
7IGF1R_20145208_ChIP-Seq_DFB_Human3.12537864
8EZH2_22144423_ChIP-Seq_EOC_Human3.06831349
9GBX2_23144817_ChIP-Seq_PC3_Human2.69416522
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.39844077
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.34160577
12ZNF274_21170338_ChIP-Seq_K562_Hela2.19762467
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.14063264
14NOTCH1_21737748_ChIP-Seq_TLL_Human1.93723761
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.92959123
16CTBP1_25329375_ChIP-Seq_LNCAP_Human1.86443196
17LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.84161335
18BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.83972456
19POU3F2_20337985_ChIP-ChIP_501MEL_Human1.76015323
20FUS_26573619_Chip-Seq_HEK293_Human1.75537340
21TP53_16413492_ChIP-PET_HCT116_Human1.71933256
22TDRD3_21172665_ChIP-Seq_MCF-7_Human1.70808243
23SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.64595891
24IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.64542865
25CBP_20019798_ChIP-Seq_JUKART_Human1.64542865
26FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.63924665
27NR3C1_21868756_ChIP-Seq_MCF10A_Human1.60170539
28WDR5_24793694_ChIP-Seq_LNCAP_Human1.59231379
29EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.56362940
30TBL1_22424771_ChIP-Seq_293T_Human1.55250777
31AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.53755369
32KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.50757688
33VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.49467511
34TP53_22573176_ChIP-Seq_HFKS_Human1.48393361
35TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48372910
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.48315694
37MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.46270260
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45030472
39POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.43906120
40TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43906120
41PRDM14_20953172_ChIP-Seq_ESCs_Human1.42641004
42OCT1_27270436_Chip-Seq_PROSTATE_Human1.42137293
43ER_23166858_ChIP-Seq_MCF-7_Human1.40436857
44UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.37135438
45OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35004367
46MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.32870495
47TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.30644778
48GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.30064347
49STAT3_23295773_ChIP-Seq_U87_Human1.29965206
50SMAD4_21799915_ChIP-Seq_A2780_Human1.29135308
51NFYB_21822215_ChIP-Seq_K562_Human1.26672642
52BCAT_22108803_ChIP-Seq_LS180_Human1.26136735
53TAL1_26923725_Chip-Seq_HPCs_Mouse1.25874499
54REST_21632747_ChIP-Seq_MESCs_Mouse1.21771213
55RUNX2_22187159_ChIP-Seq_PCA_Human1.21386220
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21017128
57IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.17406539
58ZNF217_24962896_ChIP-Seq_MCF-7_Human1.16525985
59ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.16514365
60EGR1_23403033_ChIP-Seq_LIVER_Mouse1.13078621
61NFYA_21822215_ChIP-Seq_K562_Human1.09199100
62STAT6_21828071_ChIP-Seq_BEAS2B_Human1.08845269
63IRF1_19129219_ChIP-ChIP_H3396_Human1.07990332
64AR_25329375_ChIP-Seq_VCAP_Human1.06557581
65SMAD4_21741376_ChIP-Seq_EPCs_Human1.05899867
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04650672
67DROSHA_22980978_ChIP-Seq_HELA_Human1.04432030
68P300_19829295_ChIP-Seq_ESCs_Human1.03578746
69SCL_19346495_ChIP-Seq_HPC-7_Human1.03571583
70MYB_26560356_Chip-Seq_TH2_Human1.03093866
71LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02694783
72SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01595257
73FLI1_21867929_ChIP-Seq_TH2_Mouse1.01306793
74PHF8_20622853_ChIP-Seq_HELA_Human1.00730956
75TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99676459
76FOXA1_27270436_Chip-Seq_PROSTATE_Human0.99505913
77FOXA1_25329375_ChIP-Seq_VCAP_Human0.99505913
78GATA1_26923725_Chip-Seq_HPCs_Mouse0.97588937
79RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96790185
80ETV2_25802403_ChIP-Seq_MESCs_Mouse0.95678196
81FOXA1_21572438_ChIP-Seq_LNCaP_Human0.95214895
82TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95072773
83KDM2B_26808549_Chip-Seq_REH_Human0.94982744
84NCOR_22424771_ChIP-Seq_293T_Human0.94751577
85ETV1_20927104_ChIP-Seq_GIST48_Human0.94709659
86KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.94506235
87MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91965728
88FOXM1_26456572_ChIP-Seq_MCF-7_Human0.91413664
89GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.90825404
90TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.89763982
91ARNT_22903824_ChIP-Seq_MCF-7_Human0.88583793
92HNFA_21074721_ChIP-Seq_CACO-2_Human0.88191646
93SMAD3_21741376_ChIP-Seq_EPCs_Human0.88070691
94AHR_22903824_ChIP-Seq_MCF-7_Human0.88031112
95TCF4_23295773_ChIP-Seq_U87_Human0.87394253
96KAP1_22055183_ChIP-Seq_ESCs_Mouse0.87251270
97TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.86967438
98BMI1_23680149_ChIP-Seq_NPCS_Mouse0.85926437
99HIF1A_21447827_ChIP-Seq_MCF-7_Human0.84709354
100HTT_18923047_ChIP-ChIP_STHdh_Human0.84550630

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation7.88772687
2MP0009697_abnormal_copulation3.63496519
3MP0003252_abnormal_bile_duct3.44032280
4MP0002138_abnormal_hepatobiliary_system3.29897931
5MP0001986_abnormal_taste_sensitivity3.20122463
6MP0005171_absent_coat_pigmentation2.98386818
7MP0001968_abnormal_touch/_nociception2.96226417
8MP0002736_abnormal_nociception_after2.79905953
9MP0000371_diluted_coat_color2.58661552
10MP0003011_delayed_dark_adaptation2.49485265
11MP0009745_abnormal_behavioral_response2.47981421
12MP0003787_abnormal_imprinting2.38395236
13MP0001529_abnormal_vocalization2.09500934
14MP0000383_abnormal_hair_follicle2.07361995
15MP0004147_increased_porphyrin_level1.99881521
16MP0003195_calcinosis1.94882748
17MP0002009_preneoplasia1.93080664
18MP0001905_abnormal_dopamine_level1.82860791
19MP0004924_abnormal_behavior1.66447162
20MP0005386_behavior/neurological_phenoty1.66447162
21MP0003172_abnormal_lysosome_physiology1.58274349
22MP0004133_heterotaxia1.52426871
23MP0010678_abnormal_skin_adnexa1.47202137
24MP0001879_abnormal_lymphatic_vessel1.47119771
25MP0001501_abnormal_sleep_pattern1.43216294
26MP0002837_dystrophic_cardiac_calcinosis1.41380863
27MP0000372_irregular_coat_pigmentation1.38422804
28MP0002693_abnormal_pancreas_physiology1.38133040
29MP0008057_abnormal_DNA_replication1.37677975
30MP0000358_abnormal_cell_content/1.34094867
31MP0006072_abnormal_retinal_apoptosis1.31723623
32MP0003880_abnormal_central_pattern1.31612382
33MP0001440_abnormal_grooming_behavior1.22974481
34MP0003186_abnormal_redox_activity1.22910283
35MP0003943_abnormal_hepatobiliary_system1.22899384
36MP0002168_other_aberrant_phenotype1.18096416
37MP0002075_abnormal_coat/hair_pigmentati1.17675004
38MP0005083_abnormal_biliary_tract1.17404187
39MP0002572_abnormal_emotion/affect_behav1.17312931
40MP0002272_abnormal_nervous_system1.14877003
41MP0004130_abnormal_muscle_cell1.13495100
42MP0003656_abnormal_erythrocyte_physiolo1.13429454
43MP0006035_abnormal_mitochondrial_morpho1.12278405
44MP0005253_abnormal_eye_physiology1.11043162
45MP0005220_abnormal_exocrine_pancreas1.08930664
46MP0004859_abnormal_synaptic_plasticity1.08576956
47MP0002751_abnormal_autonomic_nervous1.08489865
48MP0008961_abnormal_basal_metabolism1.05175497
49MP0005395_other_phenotype1.04649537
50MP0005551_abnormal_eye_electrophysiolog0.98235755
51MP0003638_abnormal_response/metabolism_0.98196113
52MP0005084_abnormal_gallbladder_morpholo0.98040485
53MP0002063_abnormal_learning/memory/cond0.97990127
54MP0009785_altered_susceptibility_to0.97617507
55MP0005671_abnormal_response_to0.97350010
56MP0001186_pigmentation_phenotype0.97049406
57MP0000427_abnormal_hair_cycle0.92500476
58MP0003718_maternal_effect0.91295588
59MP0000428_abnormal_craniofacial_morphol0.88636190
60MP0005410_abnormal_fertilization0.88388655
61MP0003121_genomic_imprinting0.87836579
62MP0003635_abnormal_synaptic_transmissio0.87814075
63MP0002166_altered_tumor_susceptibility0.86656214
64MP0001944_abnormal_pancreas_morphology0.85842625
65MP0001188_hyperpigmentation0.85459016
66MP0002909_abnormal_adrenal_gland0.84509817
67MP0002064_seizures0.84023191
68MP0005646_abnormal_pituitary_gland0.82147473
69MP0002877_abnormal_melanocyte_morpholog0.80913933
70MP0001486_abnormal_startle_reflex0.80775374
71MP0010386_abnormal_urinary_bladder0.80285026
72MP0005636_abnormal_mineral_homeostasis0.78319219
73MP0005423_abnormal_somatic_nervous0.77429538
74MP0002733_abnormal_thermal_nociception0.76450560
75MP0003937_abnormal_limbs/digits/tail_de0.74914294
76MP0005187_abnormal_penis_morphology0.73855175
77MP0009840_abnormal_foam_cell0.73540398
78MP0005075_abnormal_melanosome_morpholog0.73384198
79MP0005310_abnormal_salivary_gland0.71072739
80MP0002102_abnormal_ear_morphology0.69829408
81MP0000470_abnormal_stomach_morphology0.69516169
82MP0001764_abnormal_homeostasis0.69268308
83MP0002098_abnormal_vibrissa_morphology0.69245161
84MP0003699_abnormal_female_reproductive0.69038931
85MP0001324_abnormal_eye_pigmentation0.68840159
86MP0005025_abnormal_response_to0.67967670
87MP0003942_abnormal_urinary_system0.64285910
88MP0003632_abnormal_nervous_system0.63102641
89MP0003866_abnormal_defecation0.60915583
90MP0002069_abnormal_eating/drinking_beha0.60430983
91MP0002229_neurodegeneration0.59733637
92MP0005266_abnormal_metabolism0.58839355
93MP0003119_abnormal_digestive_system0.58499071
94MP0008770_decreased_survivor_rate0.58135179
95MP0002210_abnormal_sex_determination0.57824724
96MP0002161_abnormal_fertility/fecundity0.57196636
97MP0000609_abnormal_liver_physiology0.56829107
98MP0004808_abnormal_hematopoietic_stem0.56669410
99MP0002723_abnormal_immune_serum0.56573834
100MP0003631_nervous_system_phenotype0.56011686

Predicted human phenotypes

RankGene SetZ-score
1Action tremor (HP:0002345)8.40556271
2Genetic anticipation (HP:0003743)8.00015558
3Dysmetric saccades (HP:0000641)6.83514718
4Progressive cerebellar ataxia (HP:0002073)6.38443484
5Prostate neoplasm (HP:0100787)6.13061945
6Impaired proprioception (HP:0010831)4.68693069
7Retinal atrophy (HP:0001105)4.38278573
8Gaze-evoked nystagmus (HP:0000640)4.31819874
9Abnormality of the hepatic vasculature (HP:0006707)4.30677325
10Postural tremor (HP:0002174)4.21494568
11Abnormality of the prostate (HP:0008775)4.19358653
12Slow saccadic eye movements (HP:0000514)4.16639414
13Acute lymphatic leukemia (HP:0006721)4.15302946
14Absence seizures (HP:0002121)4.06651346
15Focal seizures (HP:0007359)3.72173354
16Hypothermia (HP:0002045)3.71475729
17Dialeptic seizures (HP:0011146)3.68379961
18Urinary bladder sphincter dysfunction (HP:0002839)3.63155952
19Pendular nystagmus (HP:0012043)3.58780852
20Limb ataxia (HP:0002070)3.49792015
21Hyperventilation (HP:0002883)3.29173748
22Hypochromic microcytic anemia (HP:0004840)3.17455733
23Severe visual impairment (HP:0001141)3.09358464
24Slender build (HP:0001533)3.05051753
25Impaired vibratory sensation (HP:0002495)3.02487886
26Focal motor seizures (HP:0011153)2.87599015
27Postural instability (HP:0002172)2.87442910
28Dysdiadochokinesis (HP:0002075)2.77378094
29Abnormality of male internal genitalia (HP:0000022)2.76439379
30Diastasis recti (HP:0001540)2.55576368
31Bilateral microphthalmos (HP:0007633)2.51535978
32Abnormality of macular pigmentation (HP:0008002)2.49270826
33Gastrointestinal infarctions (HP:0005244)2.42495486
34Clumsiness (HP:0002312)2.38209832
35Cortical visual impairment (HP:0100704)2.36682302
36Impaired smooth pursuit (HP:0007772)2.36281596
37Atonic seizures (HP:0010819)2.32349510
38Poor suck (HP:0002033)2.30576697
39Aplasia/Hypoplasia of the tibia (HP:0005772)2.29898325
40Rib fusion (HP:0000902)2.24415392
41Decreased testicular size (HP:0008734)2.23856257
42Termporal pattern (HP:0011008)2.21975419
43Insidious onset (HP:0003587)2.21975419
44Hypophosphatemic rickets (HP:0004912)2.20710592
45Short tibia (HP:0005736)2.14932776
46Status epilepticus (HP:0002133)2.13135765
47Aplasia/Hypoplasia involving the musculature (HP:0001460)2.09482078
48Bony spicule pigmentary retinopathy (HP:0007737)2.09395052
49Loss of speech (HP:0002371)2.00596698
50Hypochromic anemia (HP:0001931)1.99774840
51Carpal bone hypoplasia (HP:0001498)1.98194990
52Ureteral obstruction (HP:0006000)1.95716167
53Depressed nasal tip (HP:0000437)1.95457158
54Spinal muscular atrophy (HP:0007269)1.95003901
55Pancreatic cysts (HP:0001737)1.94794962
56Congenital stationary night blindness (HP:0007642)1.94179084
57Hypoproteinemia (HP:0003075)1.93323406
58Decreased muscle mass (HP:0003199)1.93308640
59Aplasia/hypoplasia of the humerus (HP:0006507)1.93276820
60Aplasia/Hypoplasia of the macula (HP:0008059)1.91661374
61Elevated erythrocyte sedimentation rate (HP:0003565)1.91048472
62Hypogonadotrophic hypogonadism (HP:0000044)1.89318084
63Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.84472414
64Orthostatic hypotension (HP:0001278)1.84095309
65Spontaneous hematomas (HP:0007420)1.84095027
66Macroglossia (HP:0000158)1.82100550
67Abnormality of the sella turcica (HP:0002679)1.81352294
68Postnatal microcephaly (HP:0005484)1.79544457
69Fair hair (HP:0002286)1.78909728
70Periodontitis (HP:0000704)1.78420252
71Amaurosis fugax (HP:0100576)1.77956350
72Aplasia/Hypoplasia affecting the retina (HP:0008061)1.75735328
73Chest pain (HP:0100749)1.74492102
74Incomplete penetrance (HP:0003829)1.74270733
75Arterial thrombosis (HP:0004420)1.73269205
76Short humerus (HP:0005792)1.71529210
77Progressive sensorineural hearing impairment (HP:0000408)1.70443865
78Anorexia (HP:0002039)1.68581807
79Retinitis pigmentosa (HP:0000510)1.67614425
80Metaphyseal dysplasia (HP:0100255)1.65380852
81Progressive hearing impairment (HP:0001730)1.65155771
82J-shaped sella turcica (HP:0002680)1.64625377
83Abnormality of homocysteine metabolism (HP:0010919)1.62510396
84Homocystinuria (HP:0002156)1.62510396
85Abnormality of vision evoked potentials (HP:0000649)1.62137520
86Flat occiput (HP:0005469)1.61203254
87Attenuation of retinal blood vessels (HP:0007843)1.60814547
88Deformed sella turcica (HP:0002681)1.59320976
89Sensory axonal neuropathy (HP:0003390)1.58423704
90Portal hypertension (HP:0001409)1.57645047
91Microcytic anemia (HP:0001935)1.57611679
92Arthropathy (HP:0003040)1.56503183
93Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.56304557
94Breast aplasia (HP:0100783)1.54881069
95Gingival bleeding (HP:0000225)1.54653316
96Tented upper lip vermilion (HP:0010804)1.52793566
97Prominent supraorbital ridges (HP:0000336)1.52161444
98Oculomotor apraxia (HP:0000657)1.52047559
99Hypoplasia of the odontoid process (HP:0003311)1.51599255
100Papillary thyroid carcinoma (HP:0002895)1.50602096

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK198.97973583
2OXSR14.54666104
3FRK3.67724115
4MKNK23.60660436
5MAP4K22.90276359
6TAOK12.62715561
7TAOK32.40196351
8SIK32.10284163
9MKNK11.92685167
10ADRBK21.88608279
11ALK1.79693448
12MARK11.69521539
13TLK11.69029825
14SCYL21.68792795
15ZAK1.67377873
16CSNK1G31.54944639
17PRKCG1.43389459
18SRPK11.41838721
19MAP4K11.37950166
20PRKCQ1.34461699
21CSNK1G21.34063955
22NTRK21.33501408
23CASK1.30344384
24MAPK151.25904618
25ERBB31.25674973
26WNK31.23260908
27GRK11.20158869
28SIK21.19444894
29MAP3K71.17890977
30TXK1.13789321
31CSNK1G11.04865392
32SGK11.04361405
33PNCK1.02836486
34FGR1.01021604
35TNK20.97608048
36LATS20.96223695
37MARK30.95276960
38RPS6KB20.94032922
39RPS6KA40.89958785
40ACVR1B0.89794812
41MAP3K110.89685510
42GRK60.88470065
43STK160.88201934
44MAPK130.83103614
45ERBB40.81907089
46MAP3K40.78314685
47MAP3K140.76434560
48MAP3K120.75697786
49WNK40.72326579
50PRKCE0.70954186
51PRKCZ0.70201492
52PTK2B0.58995535
53PDK20.56731359
54MAPKAPK50.56415025
55STK110.53842887
56SIK10.53801551
57CAMK40.53216973
58PKN10.52785972
59VRK10.49861750
60CHEK10.49000119
61CHEK20.46910509
62RPS6KA10.44087628
63MAP3K90.44006681
64FER0.42298397
65ERBB20.41364035
66CDK11A0.40711767
67STK30.39625618
68HIPK20.39049919
69PRKCD0.36411390
70STK240.36237687
71ITK0.35781145
72RPS6KA50.35305316
73MAPK100.33634860
74MAP2K20.33614599
75CDK150.33596860
76CDK140.32980613
77BTK0.31769001
78CDK180.30748029
79CSNK1A10.28461488
80IRAK30.28237286
81MAPK90.27589996
82CSNK1A1L0.26803265
83MAPK70.26355297
84MARK20.25191216
85CHUK0.24489422
86IKBKB0.23953635
87TGFBR20.23902897
88PRKG10.23851786
89JAK20.23832502
90CSF1R0.22782654
91CAMK2A0.22645335
92AKT10.21899633
93MTOR0.21737724
94MAP3K50.20758886
95RPS6KA20.20094659
96CDK70.19956708
97PLK30.19849301
98MAP3K10.19720632
99PRKD20.19377503
100PAK10.19126232

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001205.94380696
2Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.47208955
3Dorso-ventral axis formation_Homo sapiens_hsa043203.02337090
4Fatty acid biosynthesis_Homo sapiens_hsa000612.62157143
5Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.38312109
6Folate biosynthesis_Homo sapiens_hsa007902.27766672
7Nicotine addiction_Homo sapiens_hsa050332.06370560
8Sulfur relay system_Homo sapiens_hsa041221.96258292
9Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.95593817
10Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.82131154
11Glutamatergic synapse_Homo sapiens_hsa047241.63515874
12Amphetamine addiction_Homo sapiens_hsa050311.62380301
13Long-term depression_Homo sapiens_hsa047301.61688797
14Long-term potentiation_Homo sapiens_hsa047201.55746415
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.53141095
16Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.51363432
17Systemic lupus erythematosus_Homo sapiens_hsa053221.49736941
18Regulation of autophagy_Homo sapiens_hsa041401.47794668
19Taste transduction_Homo sapiens_hsa047421.47321265
20Olfactory transduction_Homo sapiens_hsa047401.46915347
21Caffeine metabolism_Homo sapiens_hsa002321.45185926
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.43105840
23T cell receptor signaling pathway_Homo sapiens_hsa046601.36873446
24RNA polymerase_Homo sapiens_hsa030201.35390021
25Alcoholism_Homo sapiens_hsa050341.32226654
26Phototransduction_Homo sapiens_hsa047441.26318853
27Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.24296281
28Calcium signaling pathway_Homo sapiens_hsa040201.20302788
29Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.16592741
30Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.14206040
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.13149687
32Glycosaminoglycan degradation_Homo sapiens_hsa005311.12452114
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.09337379
34Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.06030145
35Steroid hormone biosynthesis_Homo sapiens_hsa001401.05879681
36Ether lipid metabolism_Homo sapiens_hsa005651.05051095
37Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.04936383
38Oocyte meiosis_Homo sapiens_hsa041141.01928147
39Tryptophan metabolism_Homo sapiens_hsa003801.00589799
40Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.98599652
41Viral carcinogenesis_Homo sapiens_hsa052030.94622646
42Transcriptional misregulation in cancer_Homo sapiens_hsa052020.92838653
43MAPK signaling pathway_Homo sapiens_hsa040100.92134631
44Linoleic acid metabolism_Homo sapiens_hsa005910.91086942
45Serotonergic synapse_Homo sapiens_hsa047260.88532394
46Cocaine addiction_Homo sapiens_hsa050300.88066640
47Protein export_Homo sapiens_hsa030600.86653233
48Retinol metabolism_Homo sapiens_hsa008300.85912632
49Jak-STAT signaling pathway_Homo sapiens_hsa046300.84944467
50Basal transcription factors_Homo sapiens_hsa030220.83818930
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.80338133
52cAMP signaling pathway_Homo sapiens_hsa040240.79073306
53Dopaminergic synapse_Homo sapiens_hsa047280.78193836
54Lysine degradation_Homo sapiens_hsa003100.77594723
55B cell receptor signaling pathway_Homo sapiens_hsa046620.73555090
56Herpes simplex infection_Homo sapiens_hsa051680.73042151
57Gap junction_Homo sapiens_hsa045400.71420540
58Morphine addiction_Homo sapiens_hsa050320.71231775
59NF-kappa B signaling pathway_Homo sapiens_hsa040640.70969176
60alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.69655793
61Renin secretion_Homo sapiens_hsa049240.69057806
62Lysosome_Homo sapiens_hsa041420.63109872
63Circadian entrainment_Homo sapiens_hsa047130.60813990
64Pyrimidine metabolism_Homo sapiens_hsa002400.60668840
65Type II diabetes mellitus_Homo sapiens_hsa049300.60406217
66Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59514974
67Phospholipase D signaling pathway_Homo sapiens_hsa040720.58961706
68Intestinal immune network for IgA production_Homo sapiens_hsa046720.58336857
69Osteoclast differentiation_Homo sapiens_hsa043800.56834100
70Influenza A_Homo sapiens_hsa051640.55498384
71Synaptic vesicle cycle_Homo sapiens_hsa047210.54152190
72Sphingolipid metabolism_Homo sapiens_hsa006000.53951520
73Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.53922501
74Cysteine and methionine metabolism_Homo sapiens_hsa002700.53220948
75Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.51748969
76Ovarian steroidogenesis_Homo sapiens_hsa049130.51451170
77Hepatitis C_Homo sapiens_hsa051600.50199200
78Oxytocin signaling pathway_Homo sapiens_hsa049210.49315267
79Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48393062
80NOD-like receptor signaling pathway_Homo sapiens_hsa046210.48056129
81Other glycan degradation_Homo sapiens_hsa005110.47724809
82Butanoate metabolism_Homo sapiens_hsa006500.46749628
83Cholinergic synapse_Homo sapiens_hsa047250.46089082
84GABAergic synapse_Homo sapiens_hsa047270.45563768
85Purine metabolism_Homo sapiens_hsa002300.44763860
86Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.41525793
87Rheumatoid arthritis_Homo sapiens_hsa053230.40765314
88RNA degradation_Homo sapiens_hsa030180.39076149
89Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.37511131
90VEGF signaling pathway_Homo sapiens_hsa043700.37482820
91Prolactin signaling pathway_Homo sapiens_hsa049170.36917638
92TGF-beta signaling pathway_Homo sapiens_hsa043500.36849126
93Nitrogen metabolism_Homo sapiens_hsa009100.36660135
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.33736994
95Ras signaling pathway_Homo sapiens_hsa040140.33270293
96mTOR signaling pathway_Homo sapiens_hsa041500.33249384
97RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.31918300
98Circadian rhythm_Homo sapiens_hsa047100.31499517
99Non-homologous end-joining_Homo sapiens_hsa034500.31468935
100Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.31317975

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