PCMT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the type II class of protein carboxyl methyltransferase enzymes. The encoded enzyme plays a role in protein repair by recognizing and converting D-aspartyl and L-isoaspartyl residues resulting from spontaneous deamidation back to the normal L-aspartyl form. The encoded protein may play a protective role in the pathogenesis of Alzheimer's disease, and single nucleotide polymorphisms in this gene have been associated with spina bifida and premature ovarian failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)5.12639934
2proteasome assembly (GO:0043248)4.99032108
3neuronal action potential propagation (GO:0019227)4.83970090
4regulation of short-term neuronal synaptic plasticity (GO:0048172)4.80863811
5glutamate secretion (GO:0014047)4.67162759
6regulation of synaptic vesicle exocytosis (GO:2000300)4.47981952
7protein deneddylation (GO:0000338)4.35024649
8neuron cell-cell adhesion (GO:0007158)4.21715268
9protein localization to synapse (GO:0035418)4.19816065
10regulation of synaptic vesicle transport (GO:1902803)4.13178177
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.07707541
12synaptic vesicle docking involved in exocytosis (GO:0016081)4.07597545
13mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.05515701
14vocalization behavior (GO:0071625)4.01725677
15mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.97453850
16synaptic vesicle maturation (GO:0016188)3.95099069
17energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.93628452
18ATP hydrolysis coupled proton transport (GO:0015991)3.93628452
19neurotransmitter secretion (GO:0007269)3.83751668
20regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.80941969
21regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.69386681
22energy coupled proton transport, down electrochemical gradient (GO:0015985)3.64061479
23ATP synthesis coupled proton transport (GO:0015986)3.64061479
24chaperone-mediated protein transport (GO:0072321)3.62337771
25transferrin transport (GO:0033572)3.62164558
26positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.62151946
27negative regulation of synaptic transmission, GABAergic (GO:0032229)3.59260956
28negative regulation of dendrite morphogenesis (GO:0050774)3.57569184
29presynaptic membrane organization (GO:0097090)3.56642015
30regulation of glutamate receptor signaling pathway (GO:1900449)3.55228054
31respiratory electron transport chain (GO:0022904)3.51187447
32L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.50821639
33neuron-neuron synaptic transmission (GO:0007270)3.50702557
34establishment of protein localization to mitochondrial membrane (GO:0090151)3.46405502
35negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.46078523
36electron transport chain (GO:0022900)3.45475686
37synaptic transmission, glutamatergic (GO:0035249)3.41097079
38presynaptic membrane assembly (GO:0097105)3.38017766
39neurotransmitter transport (GO:0006836)3.36727515
40oxidative phosphorylation (GO:0006119)3.36142104
41positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.34943755
42regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.33673424
43calcium ion-dependent exocytosis (GO:0017156)3.33556960
44ionotropic glutamate receptor signaling pathway (GO:0035235)3.32652941
45trivalent inorganic cation transport (GO:0072512)3.31397710
46ferric iron transport (GO:0015682)3.31397710
47positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.30205211
48regulation of cellular amino acid metabolic process (GO:0006521)3.29266756
49respiratory chain complex IV assembly (GO:0008535)3.28894539
50locomotory exploration behavior (GO:0035641)3.25876753
51protein targeting to mitochondrion (GO:0006626)3.23639352
52anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.22863563
53neuromuscular process controlling posture (GO:0050884)3.21834072
54regulation of long-term neuronal synaptic plasticity (GO:0048169)3.20149969
55regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.19213882
56membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.19037453
57regulation of neuronal synaptic plasticity (GO:0048168)3.18451015
58neurotransmitter-gated ion channel clustering (GO:0072578)3.18442029
59glutamate receptor signaling pathway (GO:0007215)3.15517751
60negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.13274659
61negative regulation of ligase activity (GO:0051352)3.13274659
62regulation of neurotransmitter secretion (GO:0046928)3.12849246
63neurotransmitter uptake (GO:0001504)3.11514541
64gamma-aminobutyric acid signaling pathway (GO:0007214)3.10884883
65protein complex biogenesis (GO:0070271)3.10865302
66protein localization to mitochondrion (GO:0070585)3.10806736
67positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.10007115
68proline transport (GO:0015824)3.08859145
69regulation of neurotransmitter levels (GO:0001505)3.06150654
70exploration behavior (GO:0035640)3.06114830
71detection of calcium ion (GO:0005513)3.04346975
72membrane depolarization during action potential (GO:0086010)3.04112471
73transcription elongation from RNA polymerase III promoter (GO:0006385)3.04035642
74termination of RNA polymerase III transcription (GO:0006386)3.04035642
75DNA double-strand break processing (GO:0000729)3.03581648
76negative regulation of microtubule polymerization (GO:0031115)3.03046425
77regulation of mitochondrial translation (GO:0070129)3.02534290
78positive regulation of mitochondrial fission (GO:0090141)3.02527184
79establishment of protein localization to mitochondrion (GO:0072655)3.02124130
80regulation of synapse structural plasticity (GO:0051823)2.99495767
81regulation of excitatory postsynaptic membrane potential (GO:0060079)2.98306847
82calcium-mediated signaling using intracellular calcium source (GO:0035584)2.96333370
83positive regulation of ligase activity (GO:0051351)2.94366193
84regulation of neurotransmitter transport (GO:0051588)2.94071547
85long-term synaptic potentiation (GO:0060291)2.93838311
86regulation of protein kinase A signaling (GO:0010738)2.92592479
87regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.92353421
88CENP-A containing nucleosome assembly (GO:0034080)2.88720849
89negative regulation of cation channel activity (GO:2001258)2.88608093
90positive regulation of neurotransmitter transport (GO:0051590)2.88396510
91DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.87839738
92protein-cofactor linkage (GO:0018065)2.87694939
93regulation of postsynaptic membrane potential (GO:0060078)2.87486386
94protein neddylation (GO:0045116)2.87102882
95deoxyribose phosphate biosynthetic process (GO:0046385)2.86934027
962-deoxyribonucleotide biosynthetic process (GO:0009265)2.86934027
97deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.85516902
98positive regulation of membrane potential (GO:0045838)2.85041259
99regulation of glutamate secretion (GO:0014048)2.83788212
100mitochondrial respiratory chain complex assembly (GO:0033108)2.83210493
101L-methionine salvage (GO:0071267)2.82039773
102L-methionine biosynthetic process (GO:0071265)2.82039773
103amino acid salvage (GO:0043102)2.82039773
104regulation of vesicle fusion (GO:0031338)2.81591384
105chromatin remodeling at centromere (GO:0031055)2.81439339
106cullin deneddylation (GO:0010388)2.81282777
107neuromuscular synaptic transmission (GO:0007274)2.80996404
108signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.80281900
109signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.80281900
110signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.80281900
111synaptic vesicle transport (GO:0048489)2.79987259
112establishment of synaptic vesicle localization (GO:0097480)2.79987259
113DNA damage response, detection of DNA damage (GO:0042769)2.79856795
114positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.79818003
115intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.79579879
116signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.79579879
117mitochondrial respiratory chain complex I assembly (GO:0032981)2.79506085
118NADH dehydrogenase complex assembly (GO:0010257)2.79506085
119mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.79506085
120negative regulation of dendrite development (GO:2000171)2.79393868
121negative regulation of heart rate (GO:0010459)2.78329492
122synaptic vesicle endocytosis (GO:0048488)2.78094592
123ribonucleoprotein complex disassembly (GO:0032988)2.77573177
124ATP biosynthetic process (GO:0006754)2.77286767
125regulation of cell communication by electrical coupling (GO:0010649)2.77279543
126regulation of ubiquitin-protein transferase activity (GO:0051438)2.76721334
127organelle disassembly (GO:1903008)2.76017984
128protein localization to cilium (GO:0061512)2.74945647
129hydrogen ion transmembrane transport (GO:1902600)2.74672930
130NADH metabolic process (GO:0006734)2.74546880
131membrane depolarization (GO:0051899)2.74241491
132de novo protein folding (GO:0006458)2.74117750
133regulation of voltage-gated calcium channel activity (GO:1901385)2.74011166
134synaptic transmission (GO:0007268)2.73841342
135regulation of synaptic plasticity (GO:0048167)2.72728298
136regulation of synaptic transmission, glutamatergic (GO:0051966)2.72705393
137negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.72701809
138activation of protein kinase A activity (GO:0034199)2.72574399
139neuron recognition (GO:0008038)2.72225009
140negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.71496698
141signal transduction involved in cell cycle checkpoint (GO:0072395)2.69871525
142deoxyribonucleotide biosynthetic process (GO:0009263)2.69098428
143positive regulation of synaptic transmission, GABAergic (GO:0032230)2.68904371
144signal transduction involved in DNA integrity checkpoint (GO:0072401)2.68712620
145signal transduction involved in DNA damage checkpoint (GO:0072422)2.68712620
146neuronal action potential (GO:0019228)2.68051336
147de novo posttranslational protein folding (GO:0051084)2.67011872
148ribosome assembly (GO:0042255)2.66613707
149exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.66555915
150iron-sulfur cluster assembly (GO:0016226)2.66438530
151metallo-sulfur cluster assembly (GO:0031163)2.66438530
152behavioral response to cocaine (GO:0048148)2.65920345
153regulation of ligase activity (GO:0051340)2.64974652
154gamma-aminobutyric acid transport (GO:0015812)2.64830470
155cytochrome complex assembly (GO:0017004)2.64552785
156striatum development (GO:0021756)2.64387447
157nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.63624245
158purine nucleoside triphosphate biosynthetic process (GO:0009145)2.63417197
159positive regulation of potassium ion transmembrane transport (GO:1901381)2.62281406
160regulation of coenzyme metabolic process (GO:0051196)2.62215481
161regulation of cofactor metabolic process (GO:0051193)2.62215481
162purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.61412148
163regulation of cellular amine metabolic process (GO:0033238)2.60698125
164DNA replication checkpoint (GO:0000076)2.56943322
165RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.56213447
166tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.56213447
167protein K11-linked ubiquitination (GO:0070979)2.54131382
168mitochondrial transport (GO:0006839)2.53436707
169protein maturation by protein folding (GO:0022417)2.53313157
170spliceosomal snRNP assembly (GO:0000387)2.52013792
171rRNA modification (GO:0000154)2.51779362
172tricarboxylic acid cycle (GO:0006099)2.49922768
173inner mitochondrial membrane organization (GO:0007007)2.49164878
174pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.48721830
175tRNA aminoacylation for protein translation (GO:0006418)2.48664908
176amino acid activation (GO:0043038)2.48099459
177tRNA aminoacylation (GO:0043039)2.48099459
178histone exchange (GO:0043486)2.47573006
179deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.47125590

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.72016555
2GBX2_23144817_ChIP-Seq_PC3_Human3.61027552
3TAF15_26573619_Chip-Seq_HEK293_Human2.85165553
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.77745118
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.77639969
6REST_21632747_ChIP-Seq_MESCs_Mouse2.75127398
7* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.61631965
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.51282360
9CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.50167319
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.46522017
11ELK1_19687146_ChIP-ChIP_HELA_Human2.43695355
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.38324486
13* REST_18959480_ChIP-ChIP_MESCs_Mouse2.35129503
14E2F7_22180533_ChIP-Seq_HELA_Human2.30592888
15NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.27252086
16VDR_23849224_ChIP-Seq_CD4+_Human2.23347183
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.21550097
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.19029471
19ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.17207826
20VDR_22108803_ChIP-Seq_LS180_Human2.16511046
21JARID2_20075857_ChIP-Seq_MESCs_Mouse2.12823254
22CTBP2_25329375_ChIP-Seq_LNCAP_Human2.12679407
23DCP1A_22483619_ChIP-Seq_HELA_Human2.11943551
24ZFP57_27257070_Chip-Seq_ESCs_Mouse2.11773033
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.09670088
26EZH2_27304074_Chip-Seq_ESCs_Mouse2.09142568
27SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.08335430
28SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.07771665
29ZNF274_21170338_ChIP-Seq_K562_Hela2.04986851
30MTF2_20144788_ChIP-Seq_MESCs_Mouse2.02094792
31EZH2_18974828_ChIP-Seq_MESCs_Mouse1.97835405
32RNF2_18974828_ChIP-Seq_MESCs_Mouse1.97835405
33EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.97485456
34SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.96721545
35FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.96058079
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.89327171
37GABP_19822575_ChIP-Seq_HepG2_Human1.88701711
38FOXP3_21729870_ChIP-Seq_TREG_Human1.88350624
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.87044978
40* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.86114134
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.80589394
42BMI1_23680149_ChIP-Seq_NPCS_Mouse1.80537058
43RARB_27405468_Chip-Seq_BRAIN_Mouse1.79833738
44EED_16625203_ChIP-ChIP_MESCs_Mouse1.79391580
45NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.79030403
46SUZ12_27294783_Chip-Seq_ESCs_Mouse1.79010175
47E2F1_18555785_ChIP-Seq_MESCs_Mouse1.77226886
48MYC_19030024_ChIP-ChIP_MESCs_Mouse1.76635530
49P300_19829295_ChIP-Seq_ESCs_Human1.74936753
50POU3F2_20337985_ChIP-ChIP_501MEL_Human1.71459716
51EZH2_27294783_Chip-Seq_ESCs_Mouse1.68730458
52ELF1_17652178_ChIP-ChIP_JURKAT_Human1.67787022
53IKZF1_21737484_ChIP-ChIP_HCT116_Human1.65207805
54EWS_26573619_Chip-Seq_HEK293_Human1.64763969
55* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.62815654
56* SMAD4_21799915_ChIP-Seq_A2780_Human1.62116905
57YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.60643543
58TTF2_22483619_ChIP-Seq_HELA_Human1.55313451
59MYC_18940864_ChIP-ChIP_HL60_Human1.55218626
60RBPJ_22232070_ChIP-Seq_NCS_Mouse1.53879920
61KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.53466218
62PADI4_21655091_ChIP-ChIP_MCF-7_Human1.51862891
63ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.50508830
64RNF2_27304074_Chip-Seq_ESCs_Mouse1.48448098
65PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.46910024
66IGF1R_20145208_ChIP-Seq_DFB_Human1.46211756
67AR_21572438_ChIP-Seq_LNCaP_Human1.42925240
68HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.42744368
69* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.41243683
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.38498630
71XRN2_22483619_ChIP-Seq_HELA_Human1.37407677
72FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.37158316
73YY1_21170310_ChIP-Seq_MESCs_Mouse1.36152279
74RNF2_27304074_Chip-Seq_NSC_Mouse1.35633448
75FUS_26573619_Chip-Seq_HEK293_Human1.33331839
76OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33135574
77SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33082960
78CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.32465582
79JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.31951681
80MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.31498144
81FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.29039814
82* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.28996794
83MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.27691063
84THAP11_20581084_ChIP-Seq_MESCs_Mouse1.27437758
85CBX2_27304074_Chip-Seq_ESCs_Mouse1.27322336
86* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.26599912
87* AR_25329375_ChIP-Seq_VCAP_Human1.25257297
88MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.25162731
89NR3C1_23031785_ChIP-Seq_PC12_Mouse1.23800072
90GABP_17652178_ChIP-ChIP_JURKAT_Human1.23627868
91SALL1_21062744_ChIP-ChIP_HESCs_Human1.22818836
92ER_23166858_ChIP-Seq_MCF-7_Human1.22156833
93HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.21227413
94HTT_18923047_ChIP-ChIP_STHdh_Human1.21212751
95JUN_21703547_ChIP-Seq_K562_Human1.19977542
96UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19848503
97POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.17418479
98KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.16814449
99SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16531753
100HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.15900903
101PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.13199961
102SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.13177284
103SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.12883555
104MYC_19079543_ChIP-ChIP_MESCs_Mouse1.12872797
105SMAD3_21741376_ChIP-Seq_EPCs_Human1.11746360
106TP53_22573176_ChIP-Seq_HFKS_Human1.11236236
107PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.10908676
108POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.10519820
109MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.09818408
110RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.06877351
111* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.06090028
112CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.05573901
113SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.05370465
114FLI1_27457419_Chip-Seq_LIVER_Mouse1.02986343
115SOX2_21211035_ChIP-Seq_LN229_Gbm1.01796151
116GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01414334
117DROSHA_22980978_ChIP-Seq_HELA_Human0.97463114
118* PRDM14_20953172_ChIP-Seq_ESCs_Human0.96205112
119CBP_20019798_ChIP-Seq_JUKART_Human0.95931721
120IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.95931721
121SOX9_26525672_Chip-Seq_HEART_Mouse0.95327794
122NANOG_18555785_Chip-Seq_ESCs_Mouse0.95177111
123E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.94918025
124CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93683875
125REST_19997604_ChIP-ChIP_NEURONS_Mouse0.93513818
126CREB1_15753290_ChIP-ChIP_HEK293T_Human0.92966100
127ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92561944
128P53_22127205_ChIP-Seq_FIBROBLAST_Human0.92465565
129TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.92172279
130* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.91968166
131PCGF2_27294783_Chip-Seq_ESCs_Mouse0.91264216
132NANOG_19829295_ChIP-Seq_ESCs_Human0.90925890
133SOX2_19829295_ChIP-Seq_ESCs_Human0.90925890
134STAT3_23295773_ChIP-Seq_U87_Human0.90417258
135CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.89770027
136ETS1_20019798_ChIP-Seq_JURKAT_Human0.89670499
137RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.88394159
138SRF_21415370_ChIP-Seq_HL-1_Mouse0.87767759
139RUNX2_22187159_ChIP-Seq_PCA_Human0.87480931
140TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.86874536
141EST1_17652178_ChIP-ChIP_JURKAT_Human0.86617236
142AR_21909140_ChIP-Seq_LNCAP_Human0.83597606
143E2F1_21310950_ChIP-Seq_MCF-7_Human0.83531885
144E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.82714756
145KDM5A_27292631_Chip-Seq_BREAST_Human0.82636853
146KLF5_20875108_ChIP-Seq_MESCs_Mouse0.82424506
147MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.82193894
148EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.82168863
149SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.79948901
150* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.79577219
151EZH2_27294783_Chip-Seq_NPCs_Mouse0.79366905
152CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.77851305

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.69411393
2MP0004859_abnormal_synaptic_plasticity4.49749926
3MP0001968_abnormal_touch/_nociception3.63560408
4MP0003635_abnormal_synaptic_transmissio3.46761814
5MP0004270_analgesia3.33808938
6MP0002736_abnormal_nociception_after3.28210277
7MP0002735_abnormal_chemical_nociception3.22261943
8* MP0009745_abnormal_behavioral_response3.07968444
9* MP0002064_seizures2.94467122
10* MP0009046_muscle_twitch2.88469957
11MP0002734_abnormal_mechanical_nocicepti2.84110900
12MP0002063_abnormal_learning/memory/cond2.71246290
13* MP0002272_abnormal_nervous_system2.67150502
14MP0006276_abnormal_autonomic_nervous2.67053966
15MP0002102_abnormal_ear_morphology2.56171300
16MP0002572_abnormal_emotion/affect_behav2.47947420
17MP0005423_abnormal_somatic_nervous2.41758227
18MP0001529_abnormal_vocalization2.40598334
19MP0008058_abnormal_DNA_repair2.34682531
20MP0002733_abnormal_thermal_nociception2.27724045
21MP0001970_abnormal_pain_threshold2.24931090
22MP0002822_catalepsy2.21911267
23MP0002067_abnormal_sensory_capabilities2.11284142
24MP0001440_abnormal_grooming_behavior2.07333479
25MP0001905_abnormal_dopamine_level2.06197197
26MP0001501_abnormal_sleep_pattern2.05959038
27MP0001486_abnormal_startle_reflex1.97781961
28MP0010094_abnormal_chromosome_stability1.88015026
29MP0005646_abnormal_pituitary_gland1.85709722
30MP0001986_abnormal_taste_sensitivity1.85624121
31MP0004142_abnormal_muscle_tone1.81393042
32MP0004924_abnormal_behavior1.76418691
33MP0005386_behavior/neurological_phenoty1.76418691
34MP0001984_abnormal_olfaction1.74003950
35MP0002184_abnormal_innervation1.70567089
36MP0003186_abnormal_redox_activity1.70249823
37MP0002837_dystrophic_cardiac_calcinosis1.69257616
38MP0003329_amyloid_beta_deposits1.67830563
39MP0003693_abnormal_embryo_hatching1.65593309
40MP0008932_abnormal_embryonic_tissue1.64504007
41MP0003122_maternal_imprinting1.61663406
42MP0009697_abnormal_copulation1.55941851
43MP0003718_maternal_effect1.55768539
44MP0004147_increased_porphyrin_level1.55471323
45MP0004811_abnormal_neuron_physiology1.52893180
46MP0008569_lethality_at_weaning1.51552177
47MP0004858_abnormal_nervous_system1.49355134
48MP0003879_abnormal_hair_cell1.48722681
49MP0004145_abnormal_muscle_electrophysio1.47958612
50MP0000751_myopathy1.46404276
51MP0002557_abnormal_social/conspecific_i1.46286457
52MP0010386_abnormal_urinary_bladder1.46091136
53MP0005645_abnormal_hypothalamus_physiol1.44808517
54MP0004957_abnormal_blastocyst_morpholog1.44499241
55MP0002234_abnormal_pharynx_morphology1.44117590
56MP0002090_abnormal_vision1.42563548
57MP0003646_muscle_fatigue1.39467607
58MP0001188_hyperpigmentation1.36465520
59MP0005410_abnormal_fertilization1.35146441
60MP0003786_premature_aging1.35132204
61MP0003111_abnormal_nucleus_morphology1.34731809
62MP0003806_abnormal_nucleotide_metabolis1.34232095
63MP0000955_abnormal_spinal_cord1.29202275
64MP0002066_abnormal_motor_capabilities/c1.29134558
65MP0005187_abnormal_penis_morphology1.28916967
66MP0008789_abnormal_olfactory_epithelium1.26367258
67MP0000778_abnormal_nervous_system1.25451626
68* MP0002882_abnormal_neuron_morphology1.21946082
69MP0003121_genomic_imprinting1.21815030
70MP0008872_abnormal_physiological_respon1.21448092
71MP0006072_abnormal_retinal_apoptosis1.20362483
72MP0000358_abnormal_cell_content/1.18802663
73MP0000013_abnormal_adipose_tissue1.18451129
74MP0002909_abnormal_adrenal_gland1.16368156
75MP0003077_abnormal_cell_cycle1.16238990
76MP0002876_abnormal_thyroid_physiology1.15007070
77MP0008007_abnormal_cellular_replicative1.14768798
78MP0004215_abnormal_myocardial_fiber1.14354390
79MP0003633_abnormal_nervous_system1.11402682
80MP0008995_early_reproductive_senescence1.10936359
81MP0000749_muscle_degeneration1.10339229
82MP0006035_abnormal_mitochondrial_morpho1.09059466
83MP0006036_abnormal_mitochondrial_physio1.07278652
84MP0003787_abnormal_imprinting1.04731006
85MP0003136_yellow_coat_color1.04544516
86MP0004036_abnormal_muscle_relaxation1.03609057
87MP0008877_abnormal_DNA_methylation1.02068607
88MP0005253_abnormal_eye_physiology1.00911348
89MP0005084_abnormal_gallbladder_morpholo0.99966684
90MP0002229_neurodegeneration0.99065300
91MP0009780_abnormal_chondrocyte_physiolo0.98143822
92MP0003631_nervous_system_phenotype0.97991586
93MP0000647_abnormal_sebaceous_gland0.96873680
94MP0000569_abnormal_digit_pigmentation0.95718210
95MP0002638_abnormal_pupillary_reflex0.94776079
96MP0005551_abnormal_eye_electrophysiolog0.93412697
97MP0008260_abnormal_autophagy0.93171806
98MP0002160_abnormal_reproductive_system0.92247270
99MP0001502_abnormal_circadian_rhythm0.92201295
100MP0005535_abnormal_body_temperature0.91438485
101MP0004885_abnormal_endolymph0.87925509
102MP0003656_abnormal_erythrocyte_physiolo0.86137381
103MP0006292_abnormal_olfactory_placode0.85813716
104MP0004742_abnormal_vestibular_system0.85297134
105MP0000631_abnormal_neuroendocrine_gland0.85265966
106MP0001929_abnormal_gametogenesis0.84725228
107MP0000747_muscle_weakness0.84572865
108MP0002210_abnormal_sex_determination0.84375017
109MP0003221_abnormal_cardiomyocyte_apopto0.83495142
110MP0004085_abnormal_heartbeat0.83151919
111MP0005075_abnormal_melanosome_morpholog0.82275747
112MP0003123_paternal_imprinting0.82213260
113MP0001963_abnormal_hearing_physiology0.81300467
114MP0005171_absent_coat_pigmentation0.80017246
115MP0004484_altered_response_of0.79876997
116MP0002069_abnormal_eating/drinking_beha0.79377572
117MP0004043_abnormal_pH_regulation0.79246020
118MP0001664_abnormal_digestion0.76865911
119MP0003567_abnormal_fetal_cardiomyocyte0.74675283
120MP0002752_abnormal_somatic_nervous0.74535279
121MP0001485_abnormal_pinna_reflex0.73947415
122MP0002751_abnormal_autonomic_nervous0.73541733
123* MP0002152_abnormal_brain_morphology0.72516190
124MP0002095_abnormal_skin_pigmentation0.71885818
125MP0003634_abnormal_glial_cell0.70056214
126MP0005499_abnormal_olfactory_system0.67930710
127MP0005394_taste/olfaction_phenotype0.67930710
128MP0003183_abnormal_peptide_metabolism0.67521608
129MP0005620_abnormal_muscle_contractility0.66318146
130MP0000372_irregular_coat_pigmentation0.65746944
131MP0000920_abnormal_myelination0.64106225
132MP0000604_amyloidosis0.63260639
133MP0003698_abnormal_male_reproductive0.62602440
134MP0008874_decreased_physiological_sensi0.61393406
135MP0002163_abnormal_gland_morphology0.58735642
136MP0003632_abnormal_nervous_system0.56167612
137MP0003137_abnormal_impulse_conducting0.55621069
138MP0004233_abnormal_muscle_weight0.55538749

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.34994302
2Myokymia (HP:0002411)5.26332591
3Atonic seizures (HP:0010819)4.61358564
4Acute necrotizing encephalopathy (HP:0006965)4.41192558
5Focal seizures (HP:0007359)4.23435471
6Pheochromocytoma (HP:0002666)4.21568094
7Abnormal mitochondria in muscle tissue (HP:0008316)4.21450878
8Epileptic encephalopathy (HP:0200134)4.19109392
9Neuroendocrine neoplasm (HP:0100634)4.13212210
10Febrile seizures (HP:0002373)3.87967691
11Mitochondrial inheritance (HP:0001427)3.85999378
12Visual hallucinations (HP:0002367)3.79904839
13Progressive macrocephaly (HP:0004481)3.76012449
14Absence seizures (HP:0002121)3.58885435
15Hepatocellular necrosis (HP:0001404)3.39422320
16Increased CSF lactate (HP:0002490)3.38599926
17Dialeptic seizures (HP:0011146)3.37042828
18Acute encephalopathy (HP:0006846)3.36661962
19Generalized tonic-clonic seizures (HP:0002069)3.21271690
20Progressive cerebellar ataxia (HP:0002073)3.13701046
21Hyperventilation (HP:0002883)2.96974715
22Hypothermia (HP:0002045)2.96180526
233-Methylglutaconic aciduria (HP:0003535)2.87945176
24Abnormality of the anterior horn cell (HP:0006802)2.86374813
25Degeneration of anterior horn cells (HP:0002398)2.86374813
26Poor suck (HP:0002033)2.85455879
27Limb dystonia (HP:0002451)2.79819251
28Progressive inability to walk (HP:0002505)2.77335857
29Anxiety (HP:0000739)2.77188267
30Retinal dysplasia (HP:0007973)2.76572873
31Increased serum pyruvate (HP:0003542)2.74655960
32Abnormality of glycolysis (HP:0004366)2.74655960
33Ankle clonus (HP:0011448)2.74424217
34Inability to walk (HP:0002540)2.71763883
35Hepatic necrosis (HP:0002605)2.64827843
36Medial flaring of the eyebrow (HP:0010747)2.57823090
37Decreased activity of mitochondrial respiratory chain (HP:0008972)2.56403440
38Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.56403440
39Gait imbalance (HP:0002141)2.55621060
40Delusions (HP:0000746)2.55548181
41Abnormal hair whorl (HP:0010721)2.51121084
42Optic disc pallor (HP:0000543)2.50125293
43Truncal ataxia (HP:0002078)2.48115892
44Type I transferrin isoform profile (HP:0003642)2.47729870
45Broad-based gait (HP:0002136)2.47510639
46Hypoglycemic coma (HP:0001325)2.45714587
47Abnormal eating behavior (HP:0100738)2.43966982
48CNS hypomyelination (HP:0003429)2.41805217
49Lactic acidosis (HP:0003128)2.41356052
50Methylmalonic acidemia (HP:0002912)2.38643293
51Congenital primary aphakia (HP:0007707)2.36959955
52Absent/shortened dynein arms (HP:0200106)2.36216477
53Dynein arm defect of respiratory motile cilia (HP:0012255)2.36216477
54Neoplasm of the peripheral nervous system (HP:0100007)2.34039340
55Polyphagia (HP:0002591)2.31629649
56Gaze-evoked nystagmus (HP:0000640)2.31217939
57Poor eye contact (HP:0000817)2.29496435
58Increased muscle lipid content (HP:0009058)2.29127935
59Abnormality of the labia minora (HP:0012880)2.28846949
60Exercise intolerance (HP:0003546)2.28742991
61Emotional lability (HP:0000712)2.27203620
62Increased hepatocellular lipid droplets (HP:0006565)2.26781843
63Action tremor (HP:0002345)2.23862342
64Increased serum lactate (HP:0002151)2.23144625
65Abnormal respiratory motile cilium morphology (HP:0005938)2.22881535
66Abnormal respiratory epithelium morphology (HP:0012253)2.22881535
67Fetal akinesia sequence (HP:0001989)2.22476477
68Supranuclear gaze palsy (HP:0000605)2.21079779
69Respiratory failure (HP:0002878)2.19682209
70Leukodystrophy (HP:0002415)2.19658701
71Degeneration of the lateral corticospinal tracts (HP:0002314)2.19589692
72Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.19589692
73Impaired vibration sensation in the lower limbs (HP:0002166)2.18494217
74Oligomenorrhea (HP:0000876)2.17581426
75Hyperglycinemia (HP:0002154)2.16039482
76Generalized aminoaciduria (HP:0002909)2.15836571
77Nephrogenic diabetes insipidus (HP:0009806)2.15154567
78Depression (HP:0000716)2.15091269
79Abnormality of alanine metabolism (HP:0010916)2.14927673
80Hyperalaninemia (HP:0003348)2.14927673
81Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.14927673
82CNS demyelination (HP:0007305)2.14098669
83Abnormal protein glycosylation (HP:0012346)2.12523681
84Abnormal glycosylation (HP:0012345)2.12523681
85Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.12523681
86Abnormal protein N-linked glycosylation (HP:0012347)2.12523681
87Atrophy/Degeneration involving motor neurons (HP:0007373)2.12426544
88Epileptiform EEG discharges (HP:0011182)2.12232779
89Amblyopia (HP:0000646)2.11640034
90Failure to thrive in infancy (HP:0001531)2.09995128
91Exercise-induced muscle cramps (HP:0003710)2.07108388
92Impaired pain sensation (HP:0007328)2.06688601
93Abnormality of pain sensation (HP:0010832)2.06688601
94Unsteady gait (HP:0002317)2.05730370
95Myotonia (HP:0002486)2.05118723
96Lethargy (HP:0001254)2.02616235
97Type II lissencephaly (HP:0007260)2.02093302
98EEG with generalized epileptiform discharges (HP:0011198)1.98474518
99Methylmalonic aciduria (HP:0012120)1.98248966
100Abnormal gallbladder physiology (HP:0012438)1.97999072
101Cholecystitis (HP:0001082)1.97999072
102Reduced antithrombin III activity (HP:0001976)1.97524270
103Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.97365695
104Muscular hypotonia of the trunk (HP:0008936)1.96754519
105Microvesicular hepatic steatosis (HP:0001414)1.96519251
106Increased intramyocellular lipid droplets (HP:0012240)1.95993372
107Urinary urgency (HP:0000012)1.94951045
108Renal cortical cysts (HP:0000803)1.94937244
109Cerebral hypomyelination (HP:0006808)1.94904872
110Hypoventilation (HP:0002791)1.94844354
111Abnormal respiratory motile cilium physiology (HP:0012261)1.93439739
112Bradykinesia (HP:0002067)1.93430065
113Abnormal ciliary motility (HP:0012262)1.92660332
114Abnormality of the corticospinal tract (HP:0002492)1.91375930
115Abnormality of serum amino acid levels (HP:0003112)1.91365692
116Exertional dyspnea (HP:0002875)1.91099452
117Spastic gait (HP:0002064)1.90938935
118Palpitations (HP:0001962)1.89460226
119Genital tract atresia (HP:0001827)1.88398066
120Abnormality of the heme biosynthetic pathway (HP:0010472)1.87863664
121Esotropia (HP:0000565)1.86282428
122Mutism (HP:0002300)1.85801130
123Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.84999265
124X-linked dominant inheritance (HP:0001423)1.84949890
125Hypsarrhythmia (HP:0002521)1.84410701
126Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.84145363
127Cerebral edema (HP:0002181)1.84139120
128Lipid accumulation in hepatocytes (HP:0006561)1.82332894
129Rhinitis (HP:0012384)1.81202078
130Renal Fanconi syndrome (HP:0001994)1.81134857
131Postnatal microcephaly (HP:0005484)1.79758156
132Vaginal atresia (HP:0000148)1.79609729
133Abnormal social behavior (HP:0012433)1.79220888
134Impaired social interactions (HP:0000735)1.79220888
135Progressive microcephaly (HP:0000253)1.77728652
136Nausea (HP:0002018)1.74525102
137Abnormality of urine glucose concentration (HP:0011016)1.73686026
138Glycosuria (HP:0003076)1.73686026
139Shoulder girdle muscle weakness (HP:0003547)1.70275862
140Cortical dysplasia (HP:0002539)1.69114536
141Respiratory difficulties (HP:0002880)1.66114004
142Neoplasm of the adrenal gland (HP:0100631)1.62669549

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K123.85350336
2NTRK33.61913773
3MAP2K73.60675041
4MAP3K43.43800718
5CASK3.39837945
6TRIM283.34750924
7MINK12.60971239
8ARAF2.59902216
9SRPK12.44274097
10MAP2K42.31232911
11MAP4K22.31108655
12MAP3K92.18631374
13CCNB12.14875892
14NME12.11414206
15EPHA41.99286239
16PLK21.97535605
17MARK11.93007227
18CDK191.91262674
19PBK1.86215195
20GRK51.84101858
21EIF2AK31.75469752
22PDK41.75233754
23PDK31.75233754
24BCKDK1.73257327
25MST41.70738550
26DAPK21.70332363
27RIPK41.66784323
28PNCK1.65929101
29DAPK11.64055435
30PLK41.57838238
31CAMKK21.54320821
32CSNK1G11.40230042
33NTRK11.38597953
34MAPK131.37257395
35CSNK1A1L1.30906648
36PRKCG1.27424798
37KSR21.24347962
38BUB11.23571585
39WEE11.21866590
40STK161.21220053
41TTK1.20443399
42BMPR1B1.18285791
43OXSR11.15890024
44LIMK11.15616424
45ZAK1.10419758
46DYRK21.10335212
47PINK11.09697017
48BMPR21.07305196
49TSSK61.06870512
50BRAF1.06320800
51NEK11.05968516
52CDK51.05275823
53PHKG21.03582770
54PHKG11.03582770
55PLK11.02085578
56CAMK2A1.01914725
57EIF2AK11.01333926
58CDC70.99744127
59UHMK10.98785004
60SIK30.97806296
61RPS6KA40.96493450
62NUAK10.95726713
63CDK140.94567563
64CAMKK10.93639931
65PTK2B0.92324978
66NTRK20.91722156
67CDK180.89101880
68PDK20.87331758
69MYLK0.87028558
70SGK2230.85326070
71SGK4940.85326070
72MAPKAPK50.85119279
73PAK60.84056808
74PRPF4B0.84042447
75KSR10.83208112
76CAMK2G0.82793366
77CAMK2B0.82096988
78CSNK1G20.81594485
79CDK150.81154138
80FRK0.80549171
81NME20.80530273
82AKT30.78299836
83BRSK10.78082081
84BCR0.76937103
85GRK70.75407297
86PRKD30.74214655
87TESK10.72847322
88MAP3K20.71293504
89STK390.69888458
90VRK20.69752452
91CDK11A0.69420260
92BRSK20.68666911
93OBSCN0.68601443
94CSNK1G30.68366011
95PRKCE0.67445753
96FES0.66310150
97RAF10.65532637
98SCYL20.62683738
99TNIK0.62320931
100ADRBK10.62062164
101CAMK2D0.60260921
102TESK20.59308120
103ADRBK20.59274960
104INSRR0.58211334
105LMTK20.57430406
106WNK40.56809380
107MAP3K50.56606669
108SGK20.56120940
109MUSK0.55152823
110DYRK30.54058703
111PLK30.53488826
112WNK30.52563831
113CAMK10.51544934
114ILK0.49573882
115GRK10.48234447
116CSNK2A10.45945072
117MKNK10.45686686
118MAP2K10.45545511
119DAPK30.44644310
120RET0.44047407
121CDK80.43738149
122ERBB30.43708079
123CSNK1E0.42315694
124RPS6KA50.41782279
125PIM20.41261603
126AURKB0.41168072
127CSNK1A10.40166600
128ATR0.40077372
129CSNK2A20.39304127
130CDK30.38449643
131TNK20.38405623
132AURKA0.37162677
133VRK10.36668802
134DYRK1A0.36514568
135PRKACA0.34991478
136PAK30.33228551
137STK380.32676541
138WNK10.31387392
139MAP3K10.30714312

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047214.10470997
2Oxidative phosphorylation_Homo sapiens_hsa001903.72749101
3Nicotine addiction_Homo sapiens_hsa050333.50349481
4Collecting duct acid secretion_Homo sapiens_hsa049663.21323378
5Parkinsons disease_Homo sapiens_hsa050123.20084262
6Alzheimers disease_Homo sapiens_hsa050102.49631157
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.48253102
8Olfactory transduction_Homo sapiens_hsa047402.44761683
9GABAergic synapse_Homo sapiens_hsa047272.33932286
10Huntingtons disease_Homo sapiens_hsa050162.28890710
11Proteasome_Homo sapiens_hsa030502.27594761
12Mismatch repair_Homo sapiens_hsa034302.23911311
13Amphetamine addiction_Homo sapiens_hsa050312.23726326
14Circadian entrainment_Homo sapiens_hsa047132.21852979
15Cardiac muscle contraction_Homo sapiens_hsa042602.18273220
16Vibrio cholerae infection_Homo sapiens_hsa051102.13100422
17Morphine addiction_Homo sapiens_hsa050322.12533879
18Long-term potentiation_Homo sapiens_hsa047202.11419008
19Fatty acid elongation_Homo sapiens_hsa000622.03165947
20DNA replication_Homo sapiens_hsa030302.00312122
21Dopaminergic synapse_Homo sapiens_hsa047281.97760301
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.94889925
23Glutamatergic synapse_Homo sapiens_hsa047241.89277375
24Taste transduction_Homo sapiens_hsa047421.89195469
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.87952908
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.81773793
27Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.80482718
28Propanoate metabolism_Homo sapiens_hsa006401.78018105
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.75983997
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.69750797
31Insulin secretion_Homo sapiens_hsa049111.69692236
32Serotonergic synapse_Homo sapiens_hsa047261.65525567
33Homologous recombination_Homo sapiens_hsa034401.51422657
34Salivary secretion_Homo sapiens_hsa049701.46856579
35Phototransduction_Homo sapiens_hsa047441.45405223
36Cholinergic synapse_Homo sapiens_hsa047251.44692410
37Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.43755522
38SNARE interactions in vesicular transport_Homo sapiens_hsa041301.42783590
39Steroid biosynthesis_Homo sapiens_hsa001001.40269067
40Spliceosome_Homo sapiens_hsa030401.39051515
41RNA transport_Homo sapiens_hsa030131.36857013
42Base excision repair_Homo sapiens_hsa034101.36583742
43One carbon pool by folate_Homo sapiens_hsa006701.33825436
44Fanconi anemia pathway_Homo sapiens_hsa034601.33447684
45Non-homologous end-joining_Homo sapiens_hsa034501.32551107
46Renin secretion_Homo sapiens_hsa049241.32188049
47Calcium signaling pathway_Homo sapiens_hsa040201.32102180
48Gastric acid secretion_Homo sapiens_hsa049711.30745190
49Cocaine addiction_Homo sapiens_hsa050301.30579860
50Folate biosynthesis_Homo sapiens_hsa007901.29347860
51Long-term depression_Homo sapiens_hsa047301.29111708
52RNA degradation_Homo sapiens_hsa030181.28328003
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.28288218
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.23484210
55Nucleotide excision repair_Homo sapiens_hsa034201.22599332
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.21188987
57Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.20288459
58Cysteine and methionine metabolism_Homo sapiens_hsa002701.16834100
59Oxytocin signaling pathway_Homo sapiens_hsa049211.16262937
60Oocyte meiosis_Homo sapiens_hsa041141.15119580
61Protein export_Homo sapiens_hsa030601.11453710
62Sulfur metabolism_Homo sapiens_hsa009201.10382709
63Ribosome_Homo sapiens_hsa030101.03414909
64Butanoate metabolism_Homo sapiens_hsa006501.02321547
65Rheumatoid arthritis_Homo sapiens_hsa053231.02290380
66Aldosterone synthesis and secretion_Homo sapiens_hsa049251.01041882
67Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.00778644
68Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.96832034
69Biosynthesis of amino acids_Homo sapiens_hsa012300.94833237
70Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.87894963
71Gap junction_Homo sapiens_hsa045400.87547027
72Regulation of autophagy_Homo sapiens_hsa041400.86362281
73GnRH signaling pathway_Homo sapiens_hsa049120.81709465
74Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.80937836
75Pyruvate metabolism_Homo sapiens_hsa006200.80828807
76Peroxisome_Homo sapiens_hsa041460.80197455
77Cell cycle_Homo sapiens_hsa041100.78880031
78Phagosome_Homo sapiens_hsa041450.78588430
79Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.74252364
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.72476994
81cAMP signaling pathway_Homo sapiens_hsa040240.71789604
82Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70260393
83Arginine and proline metabolism_Homo sapiens_hsa003300.70231262
84Fatty acid metabolism_Homo sapiens_hsa012120.69720812
85Type I diabetes mellitus_Homo sapiens_hsa049400.69682649
86Glutathione metabolism_Homo sapiens_hsa004800.66915810
87Sulfur relay system_Homo sapiens_hsa041220.66165435
88RNA polymerase_Homo sapiens_hsa030200.66129312
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.64471783
90cGMP-PKG signaling pathway_Homo sapiens_hsa040220.62212640
91Selenocompound metabolism_Homo sapiens_hsa004500.62185668
92Vitamin B6 metabolism_Homo sapiens_hsa007500.60504973
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.58081928
94Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.56932035
95Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.55378431
96Alcoholism_Homo sapiens_hsa050340.54712751
97Purine metabolism_Homo sapiens_hsa002300.54208759
98Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54091834
99Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50850228
100Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48694431
101Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.48036522
102Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46679394
103Estrogen signaling pathway_Homo sapiens_hsa049150.46058363
104Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.45031658
105Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44602779
106N-Glycan biosynthesis_Homo sapiens_hsa005100.43284619
107Melanogenesis_Homo sapiens_hsa049160.42652227
108Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.42260206
109Nitrogen metabolism_Homo sapiens_hsa009100.41409910
110Dilated cardiomyopathy_Homo sapiens_hsa054140.40500515
111Glucagon signaling pathway_Homo sapiens_hsa049220.40013972
112mRNA surveillance pathway_Homo sapiens_hsa030150.39982419
113Thyroid hormone synthesis_Homo sapiens_hsa049180.38534697
114ErbB signaling pathway_Homo sapiens_hsa040120.37685835
115Pancreatic secretion_Homo sapiens_hsa049720.37390952
1162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.36582697
117Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.36097518
118beta-Alanine metabolism_Homo sapiens_hsa004100.35410486
119Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.34715200
120Axon guidance_Homo sapiens_hsa043600.33938681
121Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.33816199
122Pentose phosphate pathway_Homo sapiens_hsa000300.33486492
123Type II diabetes mellitus_Homo sapiens_hsa049300.33124358
124Glioma_Homo sapiens_hsa052140.30546305
125MAPK signaling pathway_Homo sapiens_hsa040100.30497425
126Circadian rhythm_Homo sapiens_hsa047100.27072419
127Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.26208549
128Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.24762466
129Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.23959802
130Prion diseases_Homo sapiens_hsa050200.23903679
131Metabolic pathways_Homo sapiens_hsa011000.23549439
132Carbon metabolism_Homo sapiens_hsa012000.23113193
133Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.21824692
134Pyrimidine metabolism_Homo sapiens_hsa002400.20645085
135Basal transcription factors_Homo sapiens_hsa030220.19457819
136Endocytosis_Homo sapiens_hsa041440.19127968
137Ras signaling pathway_Homo sapiens_hsa040140.18896044
138Glycerophospholipid metabolism_Homo sapiens_hsa005640.18374845
139Fructose and mannose metabolism_Homo sapiens_hsa000510.17495972
140Sphingolipid signaling pathway_Homo sapiens_hsa040710.14872292
141Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.14361121
142Insulin signaling pathway_Homo sapiens_hsa049100.12962621
143Neurotrophin signaling pathway_Homo sapiens_hsa047220.12566501
144Dorso-ventral axis formation_Homo sapiens_hsa043200.11286856
145African trypanosomiasis_Homo sapiens_hsa051430.10075876

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