PCK2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a mitochondrial enzyme that catalyzes the conversion of oxaloacetate to phosphoenolpyruvate in the presence of guanosine triphosphate (GTP). A cytosolic form of this protein is encoded by a different gene and is the key enzyme of gluconeogenesis in the liver. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)7.14540232
2epoxygenase P450 pathway (GO:0019373)6.90750262
3urea metabolic process (GO:0019627)6.24591959
4viral transcription (GO:0019083)6.13536776
5urea cycle (GO:0000050)5.96991877
6translational termination (GO:0006415)5.93643795
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.87081338
8regulation of fibrinolysis (GO:0051917)5.78019566
9nitrogen cycle metabolic process (GO:0071941)5.74554624
10negative regulation of fibrinolysis (GO:0051918)5.74448452
11protein targeting to ER (GO:0045047)5.72629113
12cotranslational protein targeting to membrane (GO:0006613)5.69731946
13establishment of protein localization to endoplasmic reticulum (GO:0072599)5.50649335
14very-low-density lipoprotein particle assembly (GO:0034379)5.49106654
15exogenous drug catabolic process (GO:0042738)5.47852910
16drug catabolic process (GO:0042737)5.44938389
17COPI coating of Golgi vesicle (GO:0048205)5.42309199
18Golgi transport vesicle coating (GO:0048200)5.42309199
19translational elongation (GO:0006414)5.40432460
20protein localization to endoplasmic reticulum (GO:0070972)5.31453584
21erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.25330979
22L-phenylalanine catabolic process (GO:0006559)5.25330979
23protein carboxylation (GO:0018214)5.24788016
24peptidyl-glutamic acid carboxylation (GO:0017187)5.24788016
25erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.16254846
26L-phenylalanine metabolic process (GO:0006558)5.16254846
27omega-hydroxylase P450 pathway (GO:0097267)5.07960620
28fat-soluble vitamin biosynthetic process (GO:0042362)5.04914665
29negative regulation of sterol transport (GO:0032372)5.01629147
30negative regulation of cholesterol transport (GO:0032375)5.01629147
31regulation of cholesterol esterification (GO:0010872)5.01294405
32regulation of protein activation cascade (GO:2000257)4.99425193
33plasma lipoprotein particle assembly (GO:0034377)4.94922407
34glyoxylate metabolic process (GO:0046487)4.94748739
35triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.90254833
36complement activation, alternative pathway (GO:0006957)4.88661899
37drug metabolic process (GO:0017144)4.88083347
38regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.87076760
39phospholipid efflux (GO:0033700)4.86063434
40angiotensin maturation (GO:0002003)4.84819095
41proline metabolic process (GO:0006560)4.83149690
42nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.79382778
43ethanol oxidation (GO:0006069)4.75507803
44regulation of complement activation (GO:0030449)4.74157883
45ribosomal small subunit biogenesis (GO:0042274)4.70917558
46regulation of triglyceride catabolic process (GO:0010896)4.69038678
47cellular glucuronidation (GO:0052695)4.68480787
48maturation of SSU-rRNA (GO:0030490)4.67752866
49regulation of bile acid biosynthetic process (GO:0070857)4.63051877
50positive regulation of lipoprotein lipase activity (GO:0051006)4.63045705
51positive regulation of triglyceride lipase activity (GO:0061365)4.63045705
52viral life cycle (GO:0019058)4.62575102
53translational initiation (GO:0006413)4.62405322
54glucuronate metabolic process (GO:0019585)4.59740614
55uronic acid metabolic process (GO:0006063)4.59740614
56intestinal absorption (GO:0050892)4.58556666
57cellular protein complex disassembly (GO:0043624)4.54795075
58plasma lipoprotein particle remodeling (GO:0034369)4.54393857
59protein-lipid complex remodeling (GO:0034368)4.54393857
60macromolecular complex remodeling (GO:0034367)4.54393857
61protein-lipid complex assembly (GO:0065005)4.44960663
62cholesterol efflux (GO:0033344)4.35636219
63folic acid-containing compound biosynthetic process (GO:0009396)4.35236788
64serine family amino acid biosynthetic process (GO:0009070)4.31495203
65high-density lipoprotein particle remodeling (GO:0034375)4.28102227
66fibrinolysis (GO:0042730)4.21922195
67fructose metabolic process (GO:0006000)4.21192704
68protein complex disassembly (GO:0043241)4.15458225
69bile acid metabolic process (GO:0008206)4.12073739
70L-serine metabolic process (GO:0006563)4.07963953
71maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.06605709
72blood coagulation, intrinsic pathway (GO:0007597)4.05625738
73formation of translation preinitiation complex (GO:0001731)4.04787745
74plasma lipoprotein particle organization (GO:0071827)4.00968886
75bile acid and bile salt transport (GO:0015721)4.00842307
76hormone catabolic process (GO:0042447)3.99824418
77glutamine family amino acid biosynthetic process (GO:0009084)3.97295318
78ethanol metabolic process (GO:0006067)3.97157785
79fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.94305742
80DNA strand elongation involved in DNA replication (GO:0006271)3.93899648
81telomere maintenance via semi-conservative replication (GO:0032201)3.92090593
82regulation of plasminogen activation (GO:0010755)3.91643980
83macromolecular complex disassembly (GO:0032984)3.88916242
84DNA unwinding involved in DNA replication (GO:0006268)3.88049501
85protein targeting to membrane (GO:0006612)3.85293785
86protein retention in ER lumen (GO:0006621)3.82653092
87protein-lipid complex subunit organization (GO:0071825)3.79411179
88positive regulation of fatty acid biosynthetic process (GO:0045723)3.79325175
89intestinal cholesterol absorption (GO:0030299)3.76877892
90regulation of cholesterol homeostasis (GO:2000188)3.73892487
91reverse cholesterol transport (GO:0043691)3.73609085
92DNA strand elongation (GO:0022616)3.72169861
93lipoprotein metabolic process (GO:0042157)3.71427789
94regulation of translational fidelity (GO:0006450)3.71009729
95negative regulation of blood coagulation (GO:0030195)3.69788721
96negative regulation of hemostasis (GO:1900047)3.69788721
97low-density lipoprotein particle remodeling (GO:0034374)3.67402796
98glycine metabolic process (GO:0006544)3.66808186
99complement activation, classical pathway (GO:0006958)3.66026429
100acute-phase response (GO:0006953)3.62164427
101arginine metabolic process (GO:0006525)3.61914197
102nuclear-transcribed mRNA catabolic process (GO:0000956)3.61040454
103serine family amino acid catabolic process (GO:0009071)3.57296655
104protein activation cascade (GO:0072376)3.57002261
105IMP biosynthetic process (GO:0006188)3.55811022
106acylglycerol homeostasis (GO:0055090)3.55264810
107triglyceride homeostasis (GO:0070328)3.55264810
108bile acid biosynthetic process (GO:0006699)3.53290264
109translation (GO:0006412)3.52664741
110phenylpropanoid metabolic process (GO:0009698)3.51009068
111positive regulation of nuclease activity (GO:0032075)3.49406452
112diacylglycerol metabolic process (GO:0046339)3.46962576
113ribosomal large subunit biogenesis (GO:0042273)3.45564557
114mRNA catabolic process (GO:0006402)3.45099761
115plasma lipoprotein particle clearance (GO:0034381)3.44649989
116activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.42980727
117positive regulation of lipid catabolic process (GO:0050996)3.41832836
118negative regulation of coagulation (GO:0050819)3.41270333
119antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.40308473
120antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.40308473
121DNA replication initiation (GO:0006270)3.39167062
122complement activation (GO:0006956)3.39036715
123lipoprotein transport (GO:0042953)3.39025771
124cholesterol homeostasis (GO:0042632)3.38726278
125protein maturation by protein folding (GO:0022417)3.37752840
126exocrine pancreas development (GO:0031017)3.37415818
127DNA deamination (GO:0045006)3.35443687
128flavonoid metabolic process (GO:0009812)3.34616050
129sterol homeostasis (GO:0055092)3.34562600
130glutamate metabolic process (GO:0006536)3.33680252
131telomere maintenance via recombination (GO:0000722)3.33155663
132regulation of apoptotic cell clearance (GO:2000425)3.33145473
133RNA catabolic process (GO:0006401)3.29566825
134homocysteine metabolic process (GO:0050667)3.29052442
135serine family amino acid metabolic process (GO:0009069)3.28542409
136pteridine-containing compound biosynthetic process (GO:0042559)3.27896313
137alpha-linolenic acid metabolic process (GO:0036109)3.26010001
138negative regulation of wound healing (GO:0061045)3.25819414
139regulation of nuclease activity (GO:0032069)3.25696221
140aromatic amino acid family catabolic process (GO:0009074)3.24888346
141alkaloid metabolic process (GO:0009820)3.21477811
142negative regulation of fatty acid biosynthetic process (GO:0045717)3.20371351
143protein localization to kinetochore (GO:0034501)3.19553379
144vitamin biosynthetic process (GO:0009110)3.16709166
145* NADH metabolic process (GO:0006734)3.16250266
146proline biosynthetic process (GO:0006561)3.14175260
147antigen processing and presentation via MHC class Ib (GO:0002475)3.12768256
148heme transport (GO:0015886)3.11861028
149ncRNA 3-end processing (GO:0043628)3.06948112
150mitotic recombination (GO:0006312)3.04989496
151definitive hemopoiesis (GO:0060216)3.03029409
152endoplasmic reticulum unfolded protein response (GO:0030968)3.02790360
153ribonucleoprotein complex biogenesis (GO:0022613)3.00576324
154IMP metabolic process (GO:0046040)2.97933811
155cellular response to unfolded protein (GO:0034620)2.94780206
156telomere maintenance via telomere lengthening (GO:0010833)2.90842706
157deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.85929571
158negative regulation of RNA splicing (GO:0033119)2.84593119
159cellular response to topologically incorrect protein (GO:0035967)2.82975969
160retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.81754738
161negative regulation of erythrocyte differentiation (GO:0045647)2.77602694
162nucleotide-excision repair, DNA gap filling (GO:0006297)2.76196566
163antigen processing and presentation of endogenous antigen (GO:0019883)2.70958618
164negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.70292010
165ER-nucleus signaling pathway (GO:0006984)2.68590160
166tRNA aminoacylation for protein translation (GO:0006418)2.67693277
167establishment of protein localization to membrane (GO:0090150)2.65278933
168GDP-mannose metabolic process (GO:0019673)2.63752656
169mitotic nuclear envelope disassembly (GO:0007077)2.62350215
170tRNA aminoacylation (GO:0043039)2.62223719
171amino acid activation (GO:0043038)2.62223719
172dosage compensation (GO:0007549)2.60122334
173protein autoprocessing (GO:0016540)2.57483239
174translesion synthesis (GO:0019985)2.56855043
175protein localization to chromosome, centromeric region (GO:0071459)2.56044431
176peptidyl-proline hydroxylation (GO:0019511)2.55377199
177T cell apoptotic process (GO:0070231)2.53009406
178negative regulation of phagocytosis (GO:0050765)2.48760626
179regulation of protein heterodimerization activity (GO:0043497)2.48334850
180tetrahydrofolate metabolic process (GO:0046653)2.48127414
181rRNA processing (GO:0006364)2.46193201
182DNA duplex unwinding (GO:0032508)2.44996576
183positive regulation of protein deacetylation (GO:0090312)2.44810612
184protein N-linked glycosylation via asparagine (GO:0018279)2.43693928
185DNA geometric change (GO:0032392)2.43455043
186signal peptide processing (GO:0006465)2.42366354
187heterochromatin organization (GO:0070828)2.42342968
188nucleobase biosynthetic process (GO:0046112)2.41877004
189membrane disassembly (GO:0030397)2.41830497
190nuclear envelope disassembly (GO:0051081)2.41830497
191DNA replication checkpoint (GO:0000076)2.41556994
192establishment of protein localization to organelle (GO:0072594)2.41423212
193endosome to pigment granule transport (GO:0043485)2.41290039
194endosome to melanosome transport (GO:0035646)2.41290039
195peptidyl-asparagine modification (GO:0018196)2.41020694
196protein targeting (GO:0006605)2.39251026
197response to endoplasmic reticulum stress (GO:0034976)2.39199627
198L-alpha-amino acid transmembrane transport (GO:1902475)2.39196291
199rRNA metabolic process (GO:0016072)2.37331872

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.51167301
2E2F7_22180533_ChIP-Seq_HELA_Human6.72518913
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.55889358
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.23068983
5PPARA_22158963_ChIP-Seq_LIVER_Mouse4.07483840
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.04856946
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.76056987
8LXR_22158963_ChIP-Seq_LIVER_Mouse3.37044509
9EGR1_23403033_ChIP-Seq_LIVER_Mouse3.27104347
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.02191670
11CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.99280303
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.70181788
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.67209395
14* MYC_22102868_ChIP-Seq_BL_Human2.64871204
15HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.61917672
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.55449402
17CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.45728575
18MYC_18358816_ChIP-ChIP_MESCs_Mouse2.35471644
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.32402489
20EST1_17652178_ChIP-ChIP_JURKAT_Human2.32398147
21ETS1_20019798_ChIP-Seq_JURKAT_Human2.29373448
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.29095833
23TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.27960075
24GABP_17652178_ChIP-ChIP_JURKAT_Human2.27702606
25* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.22906938
26* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.19591655
27TP63_17297297_ChIP-ChIP_HaCaT_Human2.19561297
28ZNF263_19887448_ChIP-Seq_K562_Human2.15433252
29XRN2_22483619_ChIP-Seq_HELA_Human2.15099847
30LXR_22292898_ChIP-Seq_THP-1_Human2.14184669
31VDR_21846776_ChIP-Seq_THP-1_Human2.08532700
32KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.07193406
33JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.06815416
34HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.06647616
35FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.02334639
36ELF1_17652178_ChIP-ChIP_JURKAT_Human2.01718750
37NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.96247225
38CIITA_25753668_ChIP-Seq_RAJI_Human1.95750584
39SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.92209544
40NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.89444266
41CDX2_20551321_ChIP-Seq_CACO-2_Human1.89159249
42THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.86795384
43VDR_23849224_ChIP-Seq_CD4+_Human1.84339171
44FOXP3_21729870_ChIP-Seq_TREG_Human1.82046990
45CLOCK_20551151_ChIP-Seq_293T_Human1.81992896
46NELFA_20434984_ChIP-Seq_ESCs_Mouse1.80685766
47TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77153134
48CREB1_15753290_ChIP-ChIP_HEK293T_Human1.77071991
49SCL_19346495_ChIP-Seq_HPC-7_Human1.76140074
50* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.73371963
51* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.72042839
52* DCP1A_22483619_ChIP-Seq_HELA_Human1.71505123
53FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.71069270
54RARG_19884340_ChIP-ChIP_MEFs_Mouse1.70600887
55SOX2_27498859_Chip-Seq_STOMACH_Mouse1.70535087
56TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69658602
57* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.69561622
58GABP_19822575_ChIP-Seq_HepG2_Human1.69305350
59ZFX_18555785_ChIP-Seq_MESCs_Mouse1.68046240
60TTF2_22483619_ChIP-Seq_HELA_Human1.67342198
61* RACK7_27058665_Chip-Seq_MCF-7_Human1.64317727
62E2F1_21310950_ChIP-Seq_MCF-7_Human1.63390529
63* HNF4A_19822575_ChIP-Seq_HepG2_Human1.61610360
64* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.61565268
65* GATA6_25053715_ChIP-Seq_YYC3_Human1.61206811
66NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.61138109
67TFEB_21752829_ChIP-Seq_HELA_Human1.57994241
68GATA1_22025678_ChIP-Seq_K562_Human1.57078169
69ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.56257926
70RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.54436527
71HOXB4_20404135_ChIP-ChIP_EML_Mouse1.54120774
72RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.49507988
73ESR1_15608294_ChIP-ChIP_MCF-7_Human1.49410062
74FOXA2_19822575_ChIP-Seq_HepG2_Human1.49358190
75PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49183123
76CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.48734504
77SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.48170969
78IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.48107858
79TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.45567044
80FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.45193273
81ELK1_19687146_ChIP-ChIP_HELA_Human1.43962878
82CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.42894889
83THAP11_20581084_ChIP-Seq_MESCs_Mouse1.37225208
84GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.35992575
85* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.35890396
86* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.33760021
87* SPI1_23547873_ChIP-Seq_NB4_Human1.32340756
88POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.31889263
89GATA1_22383799_ChIP-Seq_G1ME_Mouse1.30628814
90DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.29741315
91KDM5A_27292631_Chip-Seq_BREAST_Human1.29636548
92STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.28408845
93IRF8_22096565_ChIP-ChIP_GC-B_Human1.28125421
94MYB_21317192_ChIP-Seq_ERMYB_Mouse1.28012875
95AR_21909140_ChIP-Seq_LNCAP_Human1.27054748
96* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.26883573
97* GATA4_25053715_ChIP-Seq_YYC3_Human1.26719585
98SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.24253213
99POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.23034291
100* VDR_24763502_ChIP-Seq_THP-1_Human1.23010676
101KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.20963335
102HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.20142007
103CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.18681569
104* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.18032474
105NANOG_18555785_ChIP-Seq_MESCs_Mouse1.17525100
106UTX_26944678_Chip-Seq_JUKART_Human1.17177798
107CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17013513
108TET1_21451524_ChIP-Seq_MESCs_Mouse1.16488383
109PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.15594251
110NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.13101469
111SRF_21415370_ChIP-Seq_HL-1_Mouse1.13014966
112CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.12530713
113ESR2_21235772_ChIP-Seq_MCF-7_Human1.11824054
114STAT3_1855785_ChIP-Seq_MESCs_Mouse1.11419207
115* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.10918412
116* MAF_26560356_Chip-Seq_TH1_Human1.10888774
117TCF7_22412390_ChIP-Seq_EML_Mouse1.10767976
118TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.10252022
119KLF4_18555785_ChIP-Seq_MESCs_Mouse1.10025554
120RUNX1_22412390_ChIP-Seq_EML_Mouse1.10021540
121* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.09834261
122DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.09140939
123* ELK3_25401928_ChIP-Seq_HUVEC_Human1.08968610
124* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08671147
125IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.08490290
126SRY_22984422_ChIP-ChIP_TESTIS_Rat1.08283792
127NOTCH1_21737748_ChIP-Seq_TLL_Human1.07236285
128YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05956714
129NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.05436401
130CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.05204902
131* SOX2_20726797_ChIP-Seq_SW620_Human1.04869952
132SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04111998
133OCT4_18692474_ChIP-Seq_MEFs_Mouse1.03562186
134HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.02929229
135TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.02837049
136CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.02375871
137BRD4_27068464_Chip-Seq_AML-cells_Mouse1.02338616
138MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.02295781
139NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.01461309
140RXRA_24833708_ChIP-Seq_LIVER_Mouse1.00748559
141YY1_21170310_ChIP-Seq_MESCs_Mouse1.00321865
142BCOR_27268052_Chip-Seq_Bcells_Human1.00150805
143MYB_26560356_Chip-Seq_TH2_Human1.00016985
144ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.99903157
145GATA2_22383799_ChIP-Seq_G1ME_Mouse0.99184096
146* ATF3_27146783_Chip-Seq_COLON_Human0.99095232
147SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.98719274
148CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.98556215
149BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.97342266
150* MYB_26560356_Chip-Seq_TH1_Human0.96786727
151ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.96546565
152ELK1_22589737_ChIP-Seq_MCF10A_Human0.96377738
153* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95587796
154CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.95168801
155RARA_24833708_ChIP-Seq_LIVER_Mouse0.94257612
156KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.93634666
157P68_20966046_ChIP-Seq_HELA_Human0.89739787
158SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.89256550
159ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.89090772
160E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.88283989
161ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.88017217
162NCOR1_26117541_ChIP-Seq_K562_Human0.87827891
163* SA1_27219007_Chip-Seq_Bcells_Human0.87821144
164MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.87394142
165TCF3_18692474_ChIP-Seq_MEFs_Mouse0.86496053
166BCL6_27268052_Chip-Seq_Bcells_Human0.85473807
167TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85034819
168SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.83733627
169CREB1_26743006_Chip-Seq_LNCaP_Human0.82783583
170SA1_27219007_Chip-Seq_ERYTHROID_Human0.82752755
171PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82508357
172ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.82374081
173ERG_21242973_ChIP-ChIP_JURKAT_Human0.81568298
174PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.81483277
175CTCF_27219007_Chip-Seq_ERYTHROID_Human0.81131851
176* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.81128502
177CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80431256
178GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.80299810
179SMC4_20622854_ChIP-Seq_HELA_Human0.79101099

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.81896660
2MP0002139_abnormal_hepatobiliary_system7.53887208
3MP0005365_abnormal_bile_salt4.99462001
4MP0005085_abnormal_gallbladder_physiolo4.88171907
5MP0001666_abnormal_nutrient_absorption4.04878110
6MP0009840_abnormal_foam_cell3.59380253
7MP0006054_spinal_hemorrhage3.56197634
8MP0003693_abnormal_embryo_hatching3.20138178
9MP0002396_abnormal_hematopoietic_system3.08974762
10MP0008875_abnormal_xenobiotic_pharmacok3.01015550
11MP0008438_abnormal_cutaneous_collagen2.99409759
12MP0003195_calcinosis2.87348852
13MP0002877_abnormal_melanocyte_morpholog2.80892408
14MP0010352_gastrointestinal_tract_polyps2.69458311
15MP0010329_abnormal_lipoprotein_level2.68337207
16MP0004808_abnormal_hematopoietic_stem2.56736777
17MP0005220_abnormal_exocrine_pancreas2.51001426
18MP0003806_abnormal_nucleotide_metabolis2.50822148
19MP0003868_abnormal_feces_composition2.50720973
20MP0004957_abnormal_blastocyst_morpholog2.46336945
21MP0004019_abnormal_vitamin_homeostasis2.35630664
22MP0005332_abnormal_amino_acid2.35280856
23MP0003252_abnormal_bile_duct2.27872033
24MP0002138_abnormal_hepatobiliary_system2.22024657
25MP0005451_abnormal_body_composition2.21660353
26MP0000490_abnormal_crypts_of2.18945069
27MP0003111_abnormal_nucleus_morphology2.07862067
28MP0003077_abnormal_cell_cycle2.04143377
29MP0010094_abnormal_chromosome_stability1.97362369
30MP0003191_abnormal_cellular_cholesterol1.96732228
31MP0003300_gastrointestinal_ulcer1.91841073
32MP0008007_abnormal_cellular_replicative1.91024908
33MP0003283_abnormal_digestive_organ1.89896056
34MP0000609_abnormal_liver_physiology1.84017879
35MP0001545_abnormal_hematopoietic_system1.78945893
36MP0005397_hematopoietic_system_phenotyp1.78945893
37MP0003279_aneurysm1.72537488
38MP0001764_abnormal_homeostasis1.70226548
39MP0003566_abnormal_cell_adhesion1.69838089
40MP0010234_abnormal_vibrissa_follicle1.66669412
41MP0005503_abnormal_tendon_morphology1.66549052
42MP0010307_abnormal_tumor_latency1.58527631
43MP0002118_abnormal_lipid_homeostasis1.56148111
44MP0001944_abnormal_pancreas_morphology1.55678971
45MP0003705_abnormal_hypodermis_morpholog1.53431377
46MP0000013_abnormal_adipose_tissue1.48967168
47MP0009697_abnormal_copulation1.46284023
48MP0009643_abnormal_urine_homeostasis1.45239582
49MP0009278_abnormal_bone_marrow1.45146095
50MP0005670_abnormal_white_adipose1.38950063
51MP0005023_abnormal_wound_healing1.34370453
52MP0002693_abnormal_pancreas_physiology1.33989402
53MP0000350_abnormal_cell_proliferation1.33506342
54MP0009333_abnormal_splenocyte_physiolog1.32753790
55MP0000858_altered_metastatic_potential1.31627701
56MP0005076_abnormal_cell_differentiation1.31570287
57MP0000465_gastrointestinal_hemorrhage1.31383754
58MP0009379_abnormal_foot_pigmentation1.30924003
59MP0002398_abnormal_bone_marrow1.27482927
60MP0005275_abnormal_skin_tensile1.25569439
61MP0001873_stomach_inflammation1.25450519
62MP0005319_abnormal_enzyme/_coenzyme1.24928327
63MP0002019_abnormal_tumor_incidence1.19419006
64MP0008057_abnormal_DNA_replication1.19085346
65MP0004264_abnormal_extraembryonic_tissu1.18773646
66MP0005174_abnormal_tail_pigmentation1.18182840
67MP0003763_abnormal_thymus_physiology1.16256044
68MP0001986_abnormal_taste_sensitivity1.15107629
69MP0008058_abnormal_DNA_repair1.14603059
70MP0005464_abnormal_platelet_physiology1.14586453
71MP0001348_abnormal_lacrimal_gland1.14332175
72MP0002876_abnormal_thyroid_physiology1.14312899
73MP0002254_reproductive_system_inflammat1.14152786
74MP0003172_abnormal_lysosome_physiology1.13997040
75MP0000003_abnormal_adipose_tissue1.13156643
76MP0001730_embryonic_growth_arrest1.12908065
77MP0003123_paternal_imprinting1.11792650
78MP0003866_abnormal_defecation1.10788313
79MP0000313_abnormal_cell_death1.10570738
80MP0005636_abnormal_mineral_homeostasis1.10201482
81MP0000678_abnormal_parathyroid_gland1.10058727
82MP0002166_altered_tumor_susceptibility1.10027105
83MP0000689_abnormal_spleen_morphology1.08384860
84MP0002722_abnormal_immune_system1.08323441
85MP0000685_abnormal_immune_system1.08238588
86MP0002080_prenatal_lethality1.06901368
87MP0000703_abnormal_thymus_morphology1.05892738
88MP0000604_amyloidosis1.04096729
89MP0004858_abnormal_nervous_system1.03818317
90MP0005584_abnormal_enzyme/coenzyme_acti1.03565213
91MP0000598_abnormal_liver_morphology1.03244749
92MP0005408_hypopigmentation1.02641699
93MP0008932_abnormal_embryonic_tissue1.02009588
94MP0003183_abnormal_peptide_metabolism1.01495554
95MP0005409_darkened_coat_color0.99817923
96MP0008469_abnormal_protein_level0.97303791
97MP0002429_abnormal_blood_cell0.96678077
98MP0000358_abnormal_cell_content/0.94611286
99MP0002060_abnormal_skin_morphology0.94105651
100MP0001697_abnormal_embryo_size0.93431349
101MP0000477_abnormal_intestine_morphology0.92716481
102MP0003656_abnormal_erythrocyte_physiolo0.91045598
103MP0002933_joint_inflammation0.90440745
104MP0005058_abnormal_lysosome_morphology0.90366413
105MP0002896_abnormal_bone_mineralization0.87935423
106MP0002971_abnormal_brown_adipose0.86938199
107MP0001661_extended_life_span0.85826378
108MP0009642_abnormal_blood_homeostasis0.85294741
109MP0004782_abnormal_surfactant_physiolog0.85007463
110MP0010155_abnormal_intestine_physiology0.84569753
111MP0004147_increased_porphyrin_level0.83788377
112MP0010386_abnormal_urinary_bladder0.82603015
113MP0005621_abnormal_cell_physiology0.82469679
114MP0004197_abnormal_fetal_growth/weight/0.82381458
115MP0000716_abnormal_immune_system0.82113714
116MP0003436_decreased_susceptibility_to0.81259086
117MP0001958_emphysema0.81121856
118MP0002796_impaired_skin_barrier0.80906538
119MP0001835_abnormal_antigen_presentation0.80310678
120MP0002132_abnormal_respiratory_system0.78615036
121MP0003941_abnormal_skin_development0.78538466
122MP0005384_cellular_phenotype0.78459563
123MP0003718_maternal_effect0.77696405
124MP0003795_abnormal_bone_structure0.77538037
125MP0002095_abnormal_skin_pigmentation0.76720407
126MP0002086_abnormal_extraembryonic_tissu0.76471625
127MP0008260_abnormal_autophagy0.75685200
128MP0003984_embryonic_growth_retardation0.75424252
129MP0002420_abnormal_adaptive_immunity0.74722921
130MP0002136_abnormal_kidney_physiology0.74311184
131MP0005508_abnormal_skeleton_morphology0.74039390
132MP0000566_synostosis0.73647436
133MP0002089_abnormal_postnatal_growth/wei0.73571701
134MP0009785_altered_susceptibility_to0.73371237
135MP0002088_abnormal_embryonic_growth/wei0.73246756
136MP0002452_abnormal_antigen_presenting0.73194382
137MP0001672_abnormal_embryogenesis/_devel0.71971582
138MP0005380_embryogenesis_phenotype0.71971582
139MP0001243_abnormal_dermal_layer0.71548833
140MP0001270_distended_abdomen0.71496849
141MP0001819_abnormal_immune_cell0.71490925
142MP0001800_abnormal_humoral_immune0.71208165
143MP0005166_decreased_susceptibility_to0.70601096
144MP0003786_premature_aging0.70495963
145MP0002084_abnormal_developmental_patter0.69890527
146MP0002085_abnormal_embryonic_tissue0.69381317
147MP0002928_abnormal_bile_duct0.67624157
148MP0002113_abnormal_skeleton_development0.67568158
149MP0005257_abnormal_intraocular_pressure0.67483190
150MP0003943_abnormal_hepatobiliary_system0.67087560
151MP0009763_increased_sensitivity_to0.66660537
152MP0005666_abnormal_adipose_tissue0.65627768
153MP0003186_abnormal_redox_activity0.65443897
154MP0003879_abnormal_hair_cell0.65176512
155MP0001845_abnormal_inflammatory_respons0.64734045
156MP0001849_ear_inflammation0.64062179
157MP0005501_abnormal_skin_physiology0.63498411
158MP0009115_abnormal_fat_cell0.62919422
159MP0001915_intracranial_hemorrhage0.61593250
160MP0003075_altered_response_to0.56877425
161MP0005395_other_phenotype0.55092010
162MP0002078_abnormal_glucose_homeostasis0.54994768
163MP0003453_abnormal_keratinocyte_physiol0.54974864
164MP0001881_abnormal_mammary_gland0.54823933
165MP0001756_abnormal_urination0.54387404
166MP0000538_abnormal_urinary_bladder0.54209715
167MP0005025_abnormal_response_to0.53143540
168MP0005376_homeostasis/metabolism_phenot0.52985082
169MP0005334_abnormal_fat_pad0.51895067
170MP0004272_abnormal_basement_membrane0.50585000
171MP0005448_abnormal_energy_balance0.49959449
172MP0003329_amyloid_beta_deposits0.48000248
173MP0004947_skin_inflammation0.47503580

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.40823773
2Abnormality of monocarboxylic acid metabolism (HP:0010996)7.09392683
3Hypobetalipoproteinemia (HP:0003563)6.58140915
4Abnormality of glutamine family amino acid metabolism (HP:0010902)5.89182369
5Complement deficiency (HP:0004431)5.82663056
6Prolonged partial thromboplastin time (HP:0003645)5.72706734
7Systemic lupus erythematosus (HP:0002725)5.71856693
8Abnormality of aromatic amino acid family metabolism (HP:0004338)5.07928114
9Abnormality of complement system (HP:0005339)4.99282125
10Xanthomatosis (HP:0000991)4.80058121
11Protrusio acetabuli (HP:0003179)4.59206338
12Thrombocytosis (HP:0001894)4.37119510
13Abnormality of cells of the erythroid lineage (HP:0012130)4.30395041
14Joint hemorrhage (HP:0005261)4.29610343
15Glomerulonephritis (HP:0000099)4.13418308
16Reticulocytopenia (HP:0001896)4.10777683
17Abnormal number of erythroid precursors (HP:0012131)4.07098517
18Abnormality of proline metabolism (HP:0010907)3.91401977
19Hydroxyprolinuria (HP:0003080)3.91401977
20Aplastic anemia (HP:0001915)3.79746218
21Intrahepatic cholestasis (HP:0001406)3.72911008
22Conjugated hyperbilirubinemia (HP:0002908)3.72799513
23Abnormality of pyrimidine metabolism (HP:0004353)3.72457463
24Hypolipoproteinemia (HP:0010981)3.70627097
25Hemorrhage of the eye (HP:0011885)3.59487392
26Fat malabsorption (HP:0002630)3.50445395
27Cervical subluxation (HP:0003308)3.43969633
28Abnormality of glycine metabolism (HP:0010895)3.33732188
29Abnormality of serine family amino acid metabolism (HP:0010894)3.33732188
30Hyperglycinuria (HP:0003108)3.24133896
31Hyperammonemia (HP:0001987)3.21609617
32Malnutrition (HP:0004395)3.20123630
33Premature rupture of membranes (HP:0001788)3.16243020
34Abnormality of the common coagulation pathway (HP:0010990)3.09844090
35Hyperlipoproteinemia (HP:0010980)3.03184156
36Pallor (HP:0000980)2.95018905
37Ankle contracture (HP:0006466)2.94340576
3811 pairs of ribs (HP:0000878)2.93831321
39Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.87670666
40Hypercholesterolemia (HP:0003124)2.80954603
41Nephritis (HP:0000123)2.77113256
42Biconcave vertebral bodies (HP:0004586)2.69384957
43Vertebral compression fractures (HP:0002953)2.64319647
44Hypoplasia of the pons (HP:0012110)2.62564343
45Colon cancer (HP:0003003)2.61369313
46Myocardial infarction (HP:0001658)2.60652706
47Acanthocytosis (HP:0001927)2.59478583
48Widely patent fontanelles and sutures (HP:0004492)2.58910171
49Recurrent gram-negative bacterial infections (HP:0005420)2.55766422
50Abnormality of nucleobase metabolism (HP:0010932)2.54061546
51Rickets (HP:0002748)2.51361697
52IgM deficiency (HP:0002850)2.49874262
53Purpura (HP:0000979)2.47880476
54Steatorrhea (HP:0002570)2.47818084
55Vascular calcification (HP:0004934)2.46802047
56Abnormal gallbladder physiology (HP:0012438)2.46244957
57Cholecystitis (HP:0001082)2.46244957
58Slender long bone (HP:0003100)2.44479904
59Abnormality of aspartate family amino acid metabolism (HP:0010899)2.44155362
60Abnormality of sulfur amino acid metabolism (HP:0004339)2.43813618
61Macrocytic anemia (HP:0001972)2.43381182
62Abnormality of the intrinsic pathway (HP:0010989)2.42393663
63Missing ribs (HP:0000921)2.38378379
64Beaking of vertebral bodies (HP:0004568)2.37665240
65Hypophosphatemia (HP:0002148)2.37311972
66Abnormality of the calcaneus (HP:0008364)2.35409727
67Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.34908948
68Abnormal protein N-linked glycosylation (HP:0012347)2.34908948
69Abnormal protein glycosylation (HP:0012346)2.34908948
70Abnormal glycosylation (HP:0012345)2.34908948
71Ileus (HP:0002595)2.34399957
72Epidermoid cyst (HP:0200040)2.33835767
73Bowel diverticulosis (HP:0005222)2.33124380
74Petechiae (HP:0000967)2.31463472
75Cellulitis (HP:0100658)2.30947794
76Type I transferrin isoform profile (HP:0003642)2.29801941
77Nonimmune hydrops fetalis (HP:0001790)2.29607660
78Abnormality of vitamin metabolism (HP:0100508)2.29431589
79Generalized aminoaciduria (HP:0002909)2.27778723
80Soft skin (HP:0000977)2.27432037
81Thoracolumbar scoliosis (HP:0002944)2.26970886
82Hepatocellular carcinoma (HP:0001402)2.25849797
83Abnormality of alkaline phosphatase activity (HP:0004379)2.25442600
84Abnormal enzyme/coenzyme activity (HP:0012379)2.25157817
85Broad face (HP:0000283)2.23898869
86Joint stiffness (HP:0001387)2.22518869
87Abnormality of subcutaneous fat tissue (HP:0001001)2.22342750
88Hyperglycinemia (HP:0002154)2.21107651
89Cardiovascular calcification (HP:0011915)2.20659361
90Elevated alkaline phosphatase (HP:0003155)2.20385282
91Gout (HP:0001997)2.19337838
92Genu recurvatum (HP:0002816)2.16506152
93Abnormality of the pons (HP:0007361)2.15585252
94Severe short stature (HP:0003510)2.14371863
95Cerebral aneurysm (HP:0004944)2.13057894
96Megaloblastic anemia (HP:0001889)2.11668133
97Nausea (HP:0002018)2.09468213
98Thin bony cortex (HP:0002753)2.09349152
99Trismus (HP:0000211)2.08955579
100Spontaneous abortion (HP:0005268)2.08055856
101Gingival bleeding (HP:0000225)2.07373552
102Hyperbilirubinemia (HP:0002904)2.07244791
103Abnormality of T cell physiology (HP:0011840)2.06345348
104Abnormality of the acetabulum (HP:0003170)2.05518018
105Proximal tubulopathy (HP:0000114)2.05339426
106Fragile skin (HP:0001030)2.05246287
107Aortic aneurysm (HP:0004942)2.05010323
108Aortic dissection (HP:0002647)2.04197188
109Hypoalphalipoproteinemia (HP:0003233)2.03979700
110Myelodysplasia (HP:0002863)2.03721161
111Abnormality of dentin (HP:0010299)2.03551389
112Microretrognathia (HP:0000308)2.02964534
113Abnormality of urine glucose concentration (HP:0011016)2.02939571
114Glycosuria (HP:0003076)2.02939571
115Abnormality of the Achilles tendon (HP:0005109)2.02867998
116Prolonged bleeding time (HP:0003010)2.02090782
117Selective tooth agenesis (HP:0001592)2.01465398
118Reduced antithrombin III activity (HP:0001976)2.00965431
119Abnormality of purine metabolism (HP:0004352)1.99796750
120Aplasia/Hypoplasia of the sacrum (HP:0008517)1.99637082
121Abdominal distention (HP:0003270)1.98920087
122Metabolic acidosis (HP:0001942)1.97868619
123Nephrolithiasis (HP:0000787)1.97141366
124Wide cranial sutures (HP:0010537)1.96270287
125Abnormality of the anterior horn cell (HP:0006802)1.95321573
126Degeneration of anterior horn cells (HP:0002398)1.95321573
127Abnormality of serum amino acid levels (HP:0003112)1.95118481
128Abnormality of the heme biosynthetic pathway (HP:0010472)1.94982441
129Menorrhagia (HP:0000132)1.94300407
130Hypophosphatemic rickets (HP:0004912)1.94193800
131Abnormality of methionine metabolism (HP:0010901)1.93893319
132Bladder diverticulum (HP:0000015)1.93475713
133Cutaneous melanoma (HP:0012056)1.93088852
134Carpal bone hypoplasia (HP:0001498)1.91453407
135Delayed CNS myelination (HP:0002188)1.90088905
136Platyspondyly (HP:0000926)1.89360227
137Rectal prolapse (HP:0002035)1.89131990
138Radial bowing (HP:0002986)1.88637475
139Increased density of long bones (HP:0006392)1.88503013
140Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.87939563
141Vertebral hypoplasia (HP:0008417)1.87939563
142Coxa valga (HP:0002673)1.87288710
143Abnormality of endocrine pancreas physiology (HP:0012093)1.86931632
144Abnormality of the pancreatic islet cells (HP:0006476)1.86931632
145Broad palm (HP:0001169)1.86350737
146Irritability (HP:0000737)1.86277490
147Increased purine levels (HP:0004368)1.85281221
148Hyperuricemia (HP:0002149)1.85281221
149Flat acetabular roof (HP:0003180)1.85094313
150Neoplasm of the pancreas (HP:0002894)1.84287608
151Thrombophlebitis (HP:0004418)1.83718787
152Skin nodule (HP:0200036)1.83661049
153Abnormal urine phosphate concentration (HP:0012599)1.83196708
154Hyperphosphaturia (HP:0003109)1.83134746
155Dilatation of the ascending aorta (HP:0005111)1.82442718
156Decreased skull ossification (HP:0004331)1.82099716
157Abnormality of carpal bone ossification (HP:0006257)1.80504919
158Wormian bones (HP:0002645)1.79632253
159Metaphyseal cupping (HP:0003021)1.78626712
160Peritonitis (HP:0002586)1.78468340
161Cholelithiasis (HP:0001081)1.78436837
162Chronic otitis media (HP:0000389)1.78145240
163Increased serum ferritin (HP:0003281)1.77369981
164Abnormal platelet function (HP:0011869)1.77231843
165Impaired platelet aggregation (HP:0003540)1.77231843
166Abnormality of skull ossification (HP:0002703)1.77226503
167Abnormal tarsal ossification (HP:0008369)1.76915300
168Hyperacusis (HP:0010780)1.76889880
169Gastrointestinal inflammation (HP:0004386)1.75874622
170Poikilocytosis (HP:0004447)1.75744119
171Atrophic scars (HP:0001075)1.75238642
172Osteomalacia (HP:0002749)1.75072007
173Interstitial pulmonary disease (HP:0006530)1.74393195
174Recurrent bronchitis (HP:0002837)1.73875137
175Aortic regurgitation (HP:0001659)1.73500173
176Abnormal foot bone ossification (HP:0010675)1.72713283
177Chronic diarrhea (HP:0002028)1.72584853
178Mitral stenosis (HP:0001718)1.72025818
179Focal segmental glomerulosclerosis (HP:0000097)1.70675772
180Urinary glycosaminoglycan excretion (HP:0003541)1.70079501
181Mucopolysacchariduria (HP:0008155)1.70079501
182Progressive muscle weakness (HP:0003323)1.69838354
183Hypotension (HP:0002615)1.69191619
184Alkalosis (HP:0001948)1.68602109
185High pitched voice (HP:0001620)1.65773458
186Abnormality of reticulocytes (HP:0004312)1.65716042
187Enlarged penis (HP:0000040)1.63655363
188Basal cell carcinoma (HP:0002671)1.63139797
189Ulnar deviation of the wrist (HP:0003049)1.63125608
190Spinal cord compression (HP:0002176)1.63095621
191Blue sclerae (HP:0000592)1.62725370
192Flattened epiphyses (HP:0003071)1.62677598
193Hypoplasia of the odontoid process (HP:0003311)1.62390858
194Hand muscle atrophy (HP:0009130)1.61397519
195Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.58390429
196Abnormal platelet volume (HP:0011876)1.57885500

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K4.86762669
2FGFR44.64075248
3SMG13.62922274
4NME23.17369350
5FLT33.15943801
6PKN23.09592265
7ERN13.02150996
8TRIB33.00655073
9PASK3.00297039
10MST1R2.68247479
11SCYL22.61803718
12IRAK32.48315538
13ICK2.30177829
14WEE12.16797662
15CDC72.10400265
16RPS6KB22.06246286
17TGFBR12.02404258
18TAOK31.93514097
19PRPF4B1.91561352
20MAPKAPK31.90991424
21EIF2AK31.90540586
22BCKDK1.78149631
23FGFR31.73989142
24NEK21.69744513
25LRRK21.68830333
26MAP3K101.63117645
27BUB11.56702002
28PIM21.55805645
29BRSK21.55077585
30TLK11.47988591
31RPS6KA41.41407429
32PAK41.39194788
33BTK1.36472420
34MAP2K31.30251755
35HIPK21.24792941
36KIT1.24330244
37MAP4K11.22046493
38PDGFRA1.20262037
39VRK11.18347230
40ACVR1B1.17868467
41CDK81.17045855
42ZAP701.13301842
43JAK31.12747953
44PDPK11.12477816
45TSSK61.08058123
46CDK71.07243109
47EIF2AK11.03254477
48PAK20.97886176
49NEK10.93857352
50PIK3CG0.93514835
51MAP3K110.92574168
52MAP3K10.92505138
53ATR0.92288271
54TEC0.91028014
55CDC42BPA0.90500029
56AURKB0.87632071
57TAOK20.87112638
58LMTK20.86892623
59MAP3K80.86070970
60RIPK40.85983288
61MAPK150.84622490
62PTK60.84105483
63DYRK30.83903945
64SIK10.80090792
65TGFBR20.79804714
66TTK0.79051425
67STK160.78844330
68MET0.78258970
69MAP3K140.78233293
70TTN0.77212556
71PRKAA20.76040617
72MATK0.75140290
73PIK3CA0.75015016
74CSF1R0.73817072
75MAP2K20.73717329
76MAP3K130.71910625
77TAOK10.71553566
78TRPM70.71550815
79PIM10.70880559
80MAP3K20.69552206
81CAMKK20.69339665
82ILK0.69275539
83VRK20.68741497
84PTK20.68033905
85STK100.67927373
86CAMK1D0.66551126
87CDK40.65826611
88FRK0.65537603
89CCNB10.65455604
90PLK10.62529721
91EPHA20.61501529
92BRSK10.60159061
93TESK10.60115179
94CDK190.59616764
95KSR20.59242415
96PDK10.59202290
97RPS6KA60.58288455
98TBK10.58029255
99ABL20.57460640
100CDK60.57387048
101BMX0.57248531
102TAF10.57150690
103PDK20.56436413
104MTOR0.54995339
105RPS6KC10.54649950
106RPS6KL10.54649950
107PRKACG0.53401877
108WNK40.50355371
109SYK0.49966784
110DDR20.49497325
111ALK0.49041944
112SRPK10.48635739
113DYRK1B0.48602970
114MAPK110.48309041
115MAP3K30.45492592
116NEK90.44587793
117EPHB10.42506693
118RPS6KA20.42459279
119MAPKAPK50.42293531
120FGR0.41074493
121PAK10.40600571
122TESK20.40514717
123PRKG20.40471886
124CDK120.40274356
125GRK60.40083965
126RIPK10.39817426
127NLK0.38992051
128CSNK2A20.38893850
129CLK10.38842462
130RET0.38800054
131IRAK40.38626012
132FGFR10.38064577
133TYK20.37884682
134MAPKAPK20.37094664
135CHEK10.37041241
136AURKA0.36595025
137LYN0.36130374
138MKNK10.35729280
139KDR0.35691801
140AKT30.35445975
141RPS6KB10.35172303
142PRKD20.34746285
143MELK0.34713991
144JAK10.31714023
145STK240.31610052
146SRC0.30675598
147ARAF0.30411291
148PRKD30.29713611
149DAPK10.29526774
150DAPK30.28896458
151PRKCZ0.25624967
152BRAF0.24474121

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.31538430
2DNA replication_Homo sapiens_hsa030304.12456661
3Mismatch repair_Homo sapiens_hsa034303.38373977
4Arginine biosynthesis_Homo sapiens_hsa002203.09206246
5Protein export_Homo sapiens_hsa030603.03035791
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.01095785
7Complement and coagulation cascades_Homo sapiens_hsa046102.91673771
8Caffeine metabolism_Homo sapiens_hsa002322.84955918
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.79147569
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.75592762
11Primary bile acid biosynthesis_Homo sapiens_hsa001202.63813605
12Pentose and glucuronate interconversions_Homo sapiens_hsa000402.61608069
13Retinol metabolism_Homo sapiens_hsa008302.61359671
14One carbon pool by folate_Homo sapiens_hsa006702.53132395
15Base excision repair_Homo sapiens_hsa034102.53112132
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.51616713
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.49333258
18Fat digestion and absorption_Homo sapiens_hsa049752.39995907
19Drug metabolism - other enzymes_Homo sapiens_hsa009832.32057160
20Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.31049142
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.23061541
22Chemical carcinogenesis_Homo sapiens_hsa052042.21184080
23Fatty acid degradation_Homo sapiens_hsa000712.19876568
24Phenylalanine metabolism_Homo sapiens_hsa003602.18705891
25Vitamin digestion and absorption_Homo sapiens_hsa049772.14417466
26Nucleotide excision repair_Homo sapiens_hsa034202.14196097
27N-Glycan biosynthesis_Homo sapiens_hsa005102.07040175
28Histidine metabolism_Homo sapiens_hsa003402.05913948
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.03192542
30Maturity onset diabetes of the young_Homo sapiens_hsa049502.01230720
31Spliceosome_Homo sapiens_hsa030402.00386601
32Homologous recombination_Homo sapiens_hsa034401.97734312
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.90902320
34Starch and sucrose metabolism_Homo sapiens_hsa005001.90581152
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.88850694
36Cell cycle_Homo sapiens_hsa041101.85756816
37RNA transport_Homo sapiens_hsa030131.79721268
38Pyrimidine metabolism_Homo sapiens_hsa002401.72134285
39Bile secretion_Homo sapiens_hsa049761.70744692
40Tyrosine metabolism_Homo sapiens_hsa003501.70217025
41Other glycan degradation_Homo sapiens_hsa005111.68312678
42* PPAR signaling pathway_Homo sapiens_hsa033201.60664385
43Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.60406294
44Vitamin B6 metabolism_Homo sapiens_hsa007501.55193751
45RNA polymerase_Homo sapiens_hsa030201.53120388
46Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.50223017
47Arginine and proline metabolism_Homo sapiens_hsa003301.49960698
48Tryptophan metabolism_Homo sapiens_hsa003801.45062401
49p53 signaling pathway_Homo sapiens_hsa041151.44359739
50Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.41737622
51Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.36434507
52Carbon metabolism_Homo sapiens_hsa012001.35306606
53Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.31477270
54Non-homologous end-joining_Homo sapiens_hsa034501.31399944
55Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.31229012
56Staphylococcus aureus infection_Homo sapiens_hsa051501.29859831
57Protein digestion and absorption_Homo sapiens_hsa049741.29346213
58Sulfur metabolism_Homo sapiens_hsa009201.27228286
59Linoleic acid metabolism_Homo sapiens_hsa005911.20501727
60Antigen processing and presentation_Homo sapiens_hsa046121.20375540
61Proteasome_Homo sapiens_hsa030501.16516034
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.14664427
63Folate biosynthesis_Homo sapiens_hsa007901.11471687
64RNA degradation_Homo sapiens_hsa030181.10620327
65* Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.10532952
66Chronic myeloid leukemia_Homo sapiens_hsa052201.09032516
67Sulfur relay system_Homo sapiens_hsa041221.08929662
68Cysteine and methionine metabolism_Homo sapiens_hsa002701.06656555
69Butanoate metabolism_Homo sapiens_hsa006501.04650942
70Fatty acid metabolism_Homo sapiens_hsa012121.04467639
71Mineral absorption_Homo sapiens_hsa049781.04462939
72Peroxisome_Homo sapiens_hsa041461.04107553
73Selenocompound metabolism_Homo sapiens_hsa004501.00810782
74Fanconi anemia pathway_Homo sapiens_hsa034601.00070604
75Thyroid cancer_Homo sapiens_hsa052160.99923310
76Viral carcinogenesis_Homo sapiens_hsa052030.99861039
77Arachidonic acid metabolism_Homo sapiens_hsa005900.97502741
78Bladder cancer_Homo sapiens_hsa052190.93971916
79Cyanoamino acid metabolism_Homo sapiens_hsa004600.92289054
80* Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.91145437
81Pancreatic secretion_Homo sapiens_hsa049720.89921290
82Small cell lung cancer_Homo sapiens_hsa052220.88757259
83* Pyruvate metabolism_Homo sapiens_hsa006200.85591288
84HTLV-I infection_Homo sapiens_hsa051660.85497102
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.84477215
86Glycosaminoglycan degradation_Homo sapiens_hsa005310.84377983
87mRNA surveillance pathway_Homo sapiens_hsa030150.83762686
88Acute myeloid leukemia_Homo sapiens_hsa052210.83632910
89Prion diseases_Homo sapiens_hsa050200.83344300
90Legionellosis_Homo sapiens_hsa051340.81555454
91Herpes simplex infection_Homo sapiens_hsa051680.81478100
92Epstein-Barr virus infection_Homo sapiens_hsa051690.78322756
93Platelet activation_Homo sapiens_hsa046110.78076094
94Apoptosis_Homo sapiens_hsa042100.77751244
95Hepatitis B_Homo sapiens_hsa051610.77545881
96Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.76584701
97Purine metabolism_Homo sapiens_hsa002300.76350056
98ECM-receptor interaction_Homo sapiens_hsa045120.75902892
99beta-Alanine metabolism_Homo sapiens_hsa004100.72451847
100Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.71526706
101B cell receptor signaling pathway_Homo sapiens_hsa046620.71320681
102Hematopoietic cell lineage_Homo sapiens_hsa046400.70422045
103Primary immunodeficiency_Homo sapiens_hsa053400.68984581
104Galactose metabolism_Homo sapiens_hsa000520.65466041
105Glutathione metabolism_Homo sapiens_hsa004800.65244903
106Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64741768
107Glycerolipid metabolism_Homo sapiens_hsa005610.64442246
108Renin-angiotensin system_Homo sapiens_hsa046140.63237121
109AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.62260223
110Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59370172
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.59313398
112Shigellosis_Homo sapiens_hsa051310.58760518
113Propanoate metabolism_Homo sapiens_hsa006400.58076106
114Non-small cell lung cancer_Homo sapiens_hsa052230.58013653
115Focal adhesion_Homo sapiens_hsa045100.57985450
116mTOR signaling pathway_Homo sapiens_hsa041500.56481636
117Fatty acid elongation_Homo sapiens_hsa000620.55490285
118Pancreatic cancer_Homo sapiens_hsa052120.54718710
119Systemic lupus erythematosus_Homo sapiens_hsa053220.54621996
120Measles_Homo sapiens_hsa051620.53988100
121Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53964184
122Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.52351702
123Basal transcription factors_Homo sapiens_hsa030220.50691031
124MicroRNAs in cancer_Homo sapiens_hsa052060.50141331
125HIF-1 signaling pathway_Homo sapiens_hsa040660.50116109
126Pentose phosphate pathway_Homo sapiens_hsa000300.48656986
127* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.46962074
128Neurotrophin signaling pathway_Homo sapiens_hsa047220.46465187
129Lysosome_Homo sapiens_hsa041420.45863446
130* Metabolic pathways_Homo sapiens_hsa011000.44725662
131Prostate cancer_Homo sapiens_hsa052150.44042215
132Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.43593387
133Leishmaniasis_Homo sapiens_hsa051400.43343180
134* Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.42778098
135Biosynthesis of amino acids_Homo sapiens_hsa012300.42746865
136Alcoholism_Homo sapiens_hsa050340.42605479
137Notch signaling pathway_Homo sapiens_hsa043300.42604913
138Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.42527419
139Jak-STAT signaling pathway_Homo sapiens_hsa046300.41607455
140Colorectal cancer_Homo sapiens_hsa052100.41434636
141ABC transporters_Homo sapiens_hsa020100.41328744
142Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.41301827
143alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.41097178
144Influenza A_Homo sapiens_hsa051640.40801227
145Fructose and mannose metabolism_Homo sapiens_hsa000510.40471871
146Vibrio cholerae infection_Homo sapiens_hsa051100.40264821
147Proteoglycans in cancer_Homo sapiens_hsa052050.39445581
148Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39066683
149Lysine degradation_Homo sapiens_hsa003100.37921360
150Fatty acid biosynthesis_Homo sapiens_hsa000610.37705318
151Toxoplasmosis_Homo sapiens_hsa051450.36835789
152Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.36516115
153* Insulin resistance_Homo sapiens_hsa049310.35346879
154Leukocyte transendothelial migration_Homo sapiens_hsa046700.35345552
155Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.34303198
156NF-kappa B signaling pathway_Homo sapiens_hsa040640.34062956
157Carbohydrate digestion and absorption_Homo sapiens_hsa049730.32794144
158Prolactin signaling pathway_Homo sapiens_hsa049170.32132553
159Pathways in cancer_Homo sapiens_hsa052000.31838731
160Sphingolipid metabolism_Homo sapiens_hsa006000.30996792
161Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.30448643
162SNARE interactions in vesicular transport_Homo sapiens_hsa041300.30011105
163Pertussis_Homo sapiens_hsa051330.29180006
164Steroid biosynthesis_Homo sapiens_hsa001000.28813030
165Glycerophospholipid metabolism_Homo sapiens_hsa005640.15455514
166* Glucagon signaling pathway_Homo sapiens_hsa049220.10659240
167* Adipocytokine signaling pathway_Homo sapiens_hsa049200.09119796
168Thyroid hormone synthesis_Homo sapiens_hsa049180.03752117
169Hepatitis C_Homo sapiens_hsa051600.03254707
170Amoebiasis_Homo sapiens_hsa05146-0.0594940
171Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601-0.0431329
172Ether lipid metabolism_Homo sapiens_hsa00565-0.0392298
173Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760-0.0314976
174Asthma_Homo sapiens_hsa05310-0.0201717
175* AMPK signaling pathway_Homo sapiens_hsa04152-0.0112522

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