PCDHGB8P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.87522876
2epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.88332723
3fucose catabolic process (GO:0019317)4.45525211
4L-fucose metabolic process (GO:0042354)4.45525211
5L-fucose catabolic process (GO:0042355)4.45525211
6indolalkylamine metabolic process (GO:0006586)3.88183888
7indole-containing compound catabolic process (GO:0042436)3.69045110
8indolalkylamine catabolic process (GO:0046218)3.69045110
9tryptophan catabolic process (GO:0006569)3.69045110
10detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.64802473
11pyrimidine nucleobase catabolic process (GO:0006208)3.55598156
12kynurenine metabolic process (GO:0070189)3.55129294
13tryptophan metabolic process (GO:0006568)3.47478485
14water-soluble vitamin biosynthetic process (GO:0042364)3.47332812
15DNA deamination (GO:0045006)3.46339924
16epithelial cilium movement (GO:0003351)3.44026946
17primary amino compound metabolic process (GO:1901160)3.41106616
18protein K11-linked deubiquitination (GO:0035871)3.40298416
19kidney morphogenesis (GO:0060993)3.34074799
20protein polyglutamylation (GO:0018095)3.22584387
21positive regulation of prostaglandin secretion (GO:0032308)3.19241024
22regulation of hexokinase activity (GO:1903299)3.18462860
23regulation of glucokinase activity (GO:0033131)3.18462860
24indole-containing compound metabolic process (GO:0042430)3.17667093
25serotonin metabolic process (GO:0042428)3.15026451
26positive regulation of fatty acid transport (GO:2000193)3.12559668
27regulation of action potential (GO:0098900)3.11555511
28reflex (GO:0060004)3.10720529
29nucleobase catabolic process (GO:0046113)3.10347608
30cilium or flagellum-dependent cell motility (GO:0001539)3.08182045
31nonmotile primary cilium assembly (GO:0035058)3.07434845
32somite development (GO:0061053)3.05288459
33rRNA catabolic process (GO:0016075)3.05084618
34axoneme assembly (GO:0035082)3.03623620
35response to pheromone (GO:0019236)3.01548056
36synaptic transmission, cholinergic (GO:0007271)2.95623910
37regulation of nuclear cell cycle DNA replication (GO:0033262)2.94089031
38negative regulation of synaptic transmission, GABAergic (GO:0032229)2.92298731
39negative regulation of cytosolic calcium ion concentration (GO:0051481)2.92104745
40cellular ketone body metabolic process (GO:0046950)2.89053654
41protein complex biogenesis (GO:0070271)2.88460416
42cellular biogenic amine catabolic process (GO:0042402)2.85029936
43amine catabolic process (GO:0009310)2.85029936
44protein localization to cilium (GO:0061512)2.84254275
45neuronal action potential (GO:0019228)2.84125787
46negative regulation of telomere maintenance (GO:0032205)2.82817804
47mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.81621399
48mitochondrial respiratory chain complex I assembly (GO:0032981)2.81621399
49NADH dehydrogenase complex assembly (GO:0010257)2.81621399
50positive regulation of icosanoid secretion (GO:0032305)2.81241984
51cornea development in camera-type eye (GO:0061303)2.80376015
52photoreceptor cell development (GO:0042461)2.77997964
53hindbrain development (GO:0030902)2.77437018
54cilium movement (GO:0003341)2.76204413
55phosphatidylinositol acyl-chain remodeling (GO:0036149)2.74364685
56protein-cofactor linkage (GO:0018065)2.73931805
57postsynaptic membrane organization (GO:0001941)2.73311237
58respiratory chain complex IV assembly (GO:0008535)2.72017392
59cilium organization (GO:0044782)2.71741921
60regulation of cilium movement (GO:0003352)2.69449092
61cilium assembly (GO:0042384)2.69203262
62regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.68899394
63cAMP catabolic process (GO:0006198)2.68425079
64cilium morphogenesis (GO:0060271)2.67558218
65nephron tubule morphogenesis (GO:0072078)2.66239342
66nephron epithelium morphogenesis (GO:0072088)2.66239342
67DNA double-strand break processing (GO:0000729)2.65581231
68base-excision repair, AP site formation (GO:0006285)2.65567101
69ubiquinone metabolic process (GO:0006743)2.65059890
70ubiquinone biosynthetic process (GO:0006744)2.63696028
71atrial cardiac muscle cell action potential (GO:0086014)2.60475781
72gamma-aminobutyric acid transport (GO:0015812)2.60211304
73negative regulation of transcription regulatory region DNA binding (GO:2000678)2.59322271
74axonemal dynein complex assembly (GO:0070286)2.58916610
75mitochondrial respiratory chain complex assembly (GO:0033108)2.58535344
76detection of light stimulus involved in visual perception (GO:0050908)2.56518109
77detection of light stimulus involved in sensory perception (GO:0050962)2.56518109
78piRNA metabolic process (GO:0034587)2.56462519
79alkaloid metabolic process (GO:0009820)2.54682108
80head development (GO:0060322)2.53098457
81ketone body metabolic process (GO:1902224)2.52526259
82membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.52365174
83fucosylation (GO:0036065)2.50350977
84limb bud formation (GO:0060174)2.49038828
85auditory behavior (GO:0031223)2.48383009
86intraciliary transport (GO:0042073)2.48079204
87detection of mechanical stimulus involved in sensory perception (GO:0050974)2.47579486
88benzene-containing compound metabolic process (GO:0042537)2.46410879
89regulation of microtubule-based movement (GO:0060632)2.45309992
90anterograde synaptic vesicle transport (GO:0048490)2.44723063
91positive regulation of oligodendrocyte differentiation (GO:0048714)2.44309507
92neural tube formation (GO:0001841)2.43374534
93sulfation (GO:0051923)2.43328136
94regulation of prostaglandin secretion (GO:0032306)2.43238325
95phosphatidylserine acyl-chain remodeling (GO:0036150)2.43210516
96mannosylation (GO:0097502)2.42935417
97platelet dense granule organization (GO:0060155)2.41423447
98positive regulation of organic acid transport (GO:0032892)2.40899203
99negative regulation of astrocyte differentiation (GO:0048712)2.39611882
100eye photoreceptor cell development (GO:0042462)2.39431451

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.03072618
2EZH2_22144423_ChIP-Seq_EOC_Human3.71599314
3VDR_22108803_ChIP-Seq_LS180_Human3.11951979
4GBX2_23144817_ChIP-Seq_PC3_Human2.99761381
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.75250718
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.64695381
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.55893790
8NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.22347187
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.19547672
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.08475780
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.04592937
12FUS_26573619_Chip-Seq_HEK293_Human2.00593569
13CTBP1_25329375_ChIP-Seq_LNCAP_Human2.00527056
14EWS_26573619_Chip-Seq_HEK293_Human1.98445997
15TAF15_26573619_Chip-Seq_HEK293_Human1.97420710
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.90457233
17IGF1R_20145208_ChIP-Seq_DFB_Human1.89645579
18P300_19829295_ChIP-Seq_ESCs_Human1.87597679
19CBX2_27304074_Chip-Seq_ESCs_Mouse1.74527952
20ER_23166858_ChIP-Seq_MCF-7_Human1.71590362
21REST_21632747_ChIP-Seq_MESCs_Mouse1.67526730
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.67385531
23FLI1_27457419_Chip-Seq_LIVER_Mouse1.64431862
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.61288773
25SALL1_21062744_ChIP-ChIP_HESCs_Human1.60400995
26EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.59692492
27BMI1_23680149_ChIP-Seq_NPCS_Mouse1.57820983
28UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.55345232
29MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.53525957
30PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.50311589
31STAT3_23295773_ChIP-Seq_U87_Human1.49783689
32SMAD4_21799915_ChIP-Seq_A2780_Human1.49395142
33PIAS1_25552417_ChIP-Seq_VCAP_Human1.47964405
34AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.47772903
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.47083374
36AR_25329375_ChIP-Seq_VCAP_Human1.47000596
37TP53_22573176_ChIP-Seq_HFKS_Human1.46909776
38RNF2_27304074_Chip-Seq_NSC_Mouse1.45165134
39TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44498579
40POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.44498579
41SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42560981
42IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42048435
43CBP_20019798_ChIP-Seq_JUKART_Human1.42048435
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.40312440
45TCF4_23295773_ChIP-Seq_U87_Human1.39074686
46PCGF2_27294783_Chip-Seq_ESCs_Mouse1.38435328
47BCAT_22108803_ChIP-Seq_LS180_Human1.37596466
48E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.36291342
49TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36182279
50EED_16625203_ChIP-ChIP_MESCs_Mouse1.34290223
51MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.33431242
52NOTCH1_21737748_ChIP-Seq_TLL_Human1.33164713
53GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.32574663
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.31974759
55EZH2_27304074_Chip-Seq_ESCs_Mouse1.30261155
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28973009
57SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.28931248
58MYC_18940864_ChIP-ChIP_HL60_Human1.28380455
59RUNX2_22187159_ChIP-Seq_PCA_Human1.28137262
60NR3C1_21868756_ChIP-Seq_MCF10A_Human1.27429718
61FOXA1_25329375_ChIP-Seq_VCAP_Human1.26027213
62FOXA1_27270436_Chip-Seq_PROSTATE_Human1.26027213
63POU5F1_16153702_ChIP-ChIP_HESCs_Human1.23955410
64SMAD4_21741376_ChIP-Seq_EPCs_Human1.23337509
65NANOG_19829295_ChIP-Seq_ESCs_Human1.22038840
66SOX2_19829295_ChIP-Seq_ESCs_Human1.22038840
67* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21394327
68JARID2_20064375_ChIP-Seq_MESCs_Mouse1.20767386
69IRF1_19129219_ChIP-ChIP_H3396_Human1.20583253
70GATA3_21878914_ChIP-Seq_MCF-7_Human1.19154811
71TCF4_22108803_ChIP-Seq_LS180_Human1.19132525
72ETV2_25802403_ChIP-Seq_MESCs_Mouse1.18598295
73REST_18959480_ChIP-ChIP_MESCs_Mouse1.18389978
74FLI1_21867929_ChIP-Seq_TH2_Mouse1.14536169
75SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13771731
76NCOR_22424771_ChIP-Seq_293T_Human1.11924217
77RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11684342
78GABP_17652178_ChIP-ChIP_JURKAT_Human1.11345000
79TP53_16413492_ChIP-PET_HCT116_Human1.11304285
80PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10192023
81BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.10043078
82PRDM14_20953172_ChIP-Seq_ESCs_Human1.09946349
83HOXB7_26014856_ChIP-Seq_BT474_Human1.09408509
84EZH2_27294783_Chip-Seq_ESCs_Mouse1.09358530
85SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09354673
86DROSHA_22980978_ChIP-Seq_HELA_Human1.05820837
87OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05617077
88AR_21572438_ChIP-Seq_LNCaP_Human1.04650873
89NANOG_18555785_Chip-Seq_ESCs_Mouse1.04517242
90EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04385888
91SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.03726905
92FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.02402063
93CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01821562
94TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01572281
95NFE2_27457419_Chip-Seq_LIVER_Mouse1.01484849
96TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01199088
97SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.00596279
98P53_22387025_ChIP-Seq_ESCs_Mouse0.99140641
99KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.99104900
100FOXA1_21572438_ChIP-Seq_LNCaP_Human0.98987160

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology3.38416426
2MP0000569_abnormal_digit_pigmentation2.79869286
3MP0001968_abnormal_touch/_nociception2.60045839
4MP0008877_abnormal_DNA_methylation2.59637118
5MP0006292_abnormal_olfactory_placode2.32135931
6MP0005551_abnormal_eye_electrophysiolog2.27167056
7MP0003646_muscle_fatigue2.22177868
8MP0002638_abnormal_pupillary_reflex2.06862889
9MP0003880_abnormal_central_pattern2.06055770
10MP0004133_heterotaxia2.03850161
11MP0006072_abnormal_retinal_apoptosis2.01551564
12MP0009046_muscle_twitch1.96080116
13MP0009745_abnormal_behavioral_response1.94936006
14MP0005645_abnormal_hypothalamus_physiol1.94603230
15MP0002837_dystrophic_cardiac_calcinosis1.91498661
16MP0001986_abnormal_taste_sensitivity1.87486766
17MP0006276_abnormal_autonomic_nervous1.84660832
18MP0003195_calcinosis1.83567617
19MP0004885_abnormal_endolymph1.82483530
20MP0004142_abnormal_muscle_tone1.79342888
21MP0000631_abnormal_neuroendocrine_gland1.78285653
22MP0005253_abnormal_eye_physiology1.77916098
23MP0003787_abnormal_imprinting1.75161627
24MP0002938_white_spotting1.74636173
25MP0005646_abnormal_pituitary_gland1.72840176
26MP0008872_abnormal_physiological_respon1.66975784
27MP0002736_abnormal_nociception_after1.65983916
28MP0002557_abnormal_social/conspecific_i1.60161813
29MP0001501_abnormal_sleep_pattern1.56604891
30MP0005377_hearing/vestibular/ear_phenot1.56481979
31MP0003878_abnormal_ear_physiology1.56481979
32MP0002735_abnormal_chemical_nociception1.56411766
33MP0001486_abnormal_startle_reflex1.55845028
34MP0002272_abnormal_nervous_system1.55078081
35MP0004147_increased_porphyrin_level1.54246607
36MP0001485_abnormal_pinna_reflex1.54068055
37MP0001905_abnormal_dopamine_level1.53782961
38MP0001529_abnormal_vocalization1.52843567
39MP0002876_abnormal_thyroid_physiology1.48951122
40MP0008875_abnormal_xenobiotic_pharmacok1.48726321
41MP0001984_abnormal_olfaction1.48724741
42MP0000427_abnormal_hair_cycle1.48407924
43MP0003122_maternal_imprinting1.44359639
44MP0008995_early_reproductive_senescence1.43420923
45MP0002572_abnormal_emotion/affect_behav1.43074678
46MP0002064_seizures1.41758601
47MP0000372_irregular_coat_pigmentation1.39711779
48MP0004924_abnormal_behavior1.39661567
49MP0005386_behavior/neurological_phenoty1.39661567
50MP0002909_abnormal_adrenal_gland1.39414779
51MP0000778_abnormal_nervous_system1.36598941
52MP0002733_abnormal_thermal_nociception1.34898887
53MP0003121_genomic_imprinting1.34680751
54MP0002653_abnormal_ependyma_morphology1.34631349
55MP0003136_yellow_coat_color1.33108329
56MP0003011_delayed_dark_adaptation1.33082678
57MP0004742_abnormal_vestibular_system1.31809923
58MP0004145_abnormal_muscle_electrophysio1.31619089
59MP0000383_abnormal_hair_follicle1.31017636
60MP0005084_abnormal_gallbladder_morpholo1.30759925
61MP0003635_abnormal_synaptic_transmissio1.29758964
62MP0002067_abnormal_sensory_capabilities1.28474064
63MP0001970_abnormal_pain_threshold1.26737049
64MP0002063_abnormal_learning/memory/cond1.26669322
65MP0005423_abnormal_somatic_nervous1.25105516
66MP0004043_abnormal_pH_regulation1.24353955
67MP0002163_abnormal_gland_morphology1.21122575
68MP0002822_catalepsy1.12017196
69MP0005379_endocrine/exocrine_gland_phen1.10811066
70MP0002160_abnormal_reproductive_system1.09784069
71MP0005195_abnormal_posterior_eye1.09407042
72MP0000026_abnormal_inner_ear1.08663151
73MP0003937_abnormal_limbs/digits/tail_de1.06738413
74MP0010386_abnormal_urinary_bladder1.03389805
75MP0002234_abnormal_pharynx_morphology1.03220622
76MP0002734_abnormal_mechanical_nocicepti1.03060654
77MP0001502_abnormal_circadian_rhythm1.01588833
78MP0008775_abnormal_heart_ventricle0.99819591
79MP0004215_abnormal_myocardial_fiber0.99006831
80MP0005389_reproductive_system_phenotype0.97997897
81MP0003137_abnormal_impulse_conducting0.97142017
82MP0002752_abnormal_somatic_nervous0.94707130
83MP0001963_abnormal_hearing_physiology0.92774428
84MP0000049_abnormal_middle_ear0.90913697
85MP0003890_abnormal_embryonic-extraembry0.90263873
86MP0002184_abnormal_innervation0.89619054
87MP0003119_abnormal_digestive_system0.89606445
88MP0002751_abnormal_autonomic_nervous0.88836315
89MP0001293_anophthalmia0.88716633
90MP0008789_abnormal_olfactory_epithelium0.88497363
91MP0002928_abnormal_bile_duct0.88017464
92MP0001440_abnormal_grooming_behavior0.86348289
93MP0004859_abnormal_synaptic_plasticity0.85398734
94MP0005394_taste/olfaction_phenotype0.84996264
95MP0005499_abnormal_olfactory_system0.84996264
96MP0002229_neurodegeneration0.83281280
97MP0003283_abnormal_digestive_organ0.81860684
98MP0002095_abnormal_skin_pigmentation0.80036546
99MP0003938_abnormal_ear_development0.79607586
100MP0002277_abnormal_respiratory_mucosa0.79433799

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.43317596
2Pancreatic fibrosis (HP:0100732)4.25632841
3Abnormality of midbrain morphology (HP:0002418)4.23094058
4Molar tooth sign on MRI (HP:0002419)4.23094058
5True hermaphroditism (HP:0010459)3.77466854
6Congenital stationary night blindness (HP:0007642)3.64048868
7Nephronophthisis (HP:0000090)3.63235379
8Pendular nystagmus (HP:0012043)3.30309846
9Chronic hepatic failure (HP:0100626)3.26109159
10Abnormality of the renal medulla (HP:0100957)3.17403737
11Type II lissencephaly (HP:0007260)3.13266658
12Hyperventilation (HP:0002883)3.11344042
13Medial flaring of the eyebrow (HP:0010747)3.03015556
14Limb dystonia (HP:0002451)2.95584478
15Abnormality of the renal cortex (HP:0011035)2.87702064
16Abnormal respiratory epithelium morphology (HP:0012253)2.75117120
17Abnormal respiratory motile cilium morphology (HP:0005938)2.75117120
183-Methylglutaconic aciduria (HP:0003535)2.73143091
19Hypothermia (HP:0002045)2.73138902
20Cystic liver disease (HP:0006706)2.72210792
21Gait imbalance (HP:0002141)2.68513749
22Decreased circulating renin level (HP:0003351)2.58972095
23Abolished electroretinogram (ERG) (HP:0000550)2.58942862
24Abnormal biliary tract physiology (HP:0012439)2.58884359
25Bile duct proliferation (HP:0001408)2.58884359
26Congenital primary aphakia (HP:0007707)2.51410825
27Keratoconus (HP:0000563)2.50904061
28Increased corneal curvature (HP:0100692)2.50904061
29Protruding tongue (HP:0010808)2.50517666
30Tubular atrophy (HP:0000092)2.36938366
31Abnormal drinking behavior (HP:0030082)2.35439252
32Polydipsia (HP:0001959)2.35439252
33Broad-based gait (HP:0002136)2.33280871
34Aplasia/Hypoplasia of the tongue (HP:0010295)2.31771849
35Inability to walk (HP:0002540)2.31538267
36Nephrogenic diabetes insipidus (HP:0009806)2.30593879
37Chorioretinal atrophy (HP:0000533)2.28597511
38Sclerocornea (HP:0000647)2.27826662
39Genital tract atresia (HP:0001827)2.27292700
40Lissencephaly (HP:0001339)2.27137972
41Cerebellar dysplasia (HP:0007033)2.19628883
42Vaginal atresia (HP:0000148)2.19187897
43Optic nerve hypoplasia (HP:0000609)2.15759268
44Birth length less than 3rd percentile (HP:0003561)2.14588498
45Aplasia/Hypoplasia of the patella (HP:0006498)2.10912534
46Aplasia/Hypoplasia of the tibia (HP:0005772)2.10788617
47Febrile seizures (HP:0002373)2.09902682
48Attenuation of retinal blood vessels (HP:0007843)2.08719861
49Congenital hepatic fibrosis (HP:0002612)2.07887931
50Concave nail (HP:0001598)2.07256361
51Abnormal rod and cone electroretinograms (HP:0008323)2.04806602
52Renal cortical cysts (HP:0000803)2.04789395
53Pachygyria (HP:0001302)2.03967300
54Abnormality of alanine metabolism (HP:0010916)2.02124561
55Hyperalaninemia (HP:0003348)2.02124561
56Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.02124561
57Patellar aplasia (HP:0006443)2.02042508
58Postaxial foot polydactyly (HP:0001830)2.01279009
59Anencephaly (HP:0002323)2.00457975
60Furrowed tongue (HP:0000221)1.99826161
61Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.97029418
62Gaze-evoked nystagmus (HP:0000640)1.96416689
63Polyphagia (HP:0002591)1.96161989
64Supernumerary spleens (HP:0009799)1.95214083
65Acute necrotizing encephalopathy (HP:0006965)1.94921797
66Polyuria (HP:0000103)1.94567470
67Drooling (HP:0002307)1.94272963
68Retinal dysplasia (HP:0007973)1.92922297
69Dynein arm defect of respiratory motile cilia (HP:0012255)1.92852440
70Absent/shortened dynein arms (HP:0200106)1.92852440
71Progressive inability to walk (HP:0002505)1.92688210
72Progressive macrocephaly (HP:0004481)1.92579963
73Male pseudohermaphroditism (HP:0000037)1.91911137
74Mitochondrial inheritance (HP:0001427)1.89839751
75Abnormal ciliary motility (HP:0012262)1.88890714
76Postaxial hand polydactyly (HP:0001162)1.88686114
77Aplasia/Hypoplasia of the spleen (HP:0010451)1.88118860
78Hemiparesis (HP:0001269)1.85887810
79Abnormality of the labia minora (HP:0012880)1.85837907
80Agitation (HP:0000713)1.85814694
81Decreased central vision (HP:0007663)1.84216961
82Abnormality of the renal collecting system (HP:0004742)1.83446939
83Genetic anticipation (HP:0003743)1.82413229
84Fair hair (HP:0002286)1.81117680
85Poor coordination (HP:0002370)1.75925048
86Stomach cancer (HP:0012126)1.74767622
87Short tibia (HP:0005736)1.74499018
88Hypoplasia of the pons (HP:0012110)1.73547378
89Increased CSF lactate (HP:0002490)1.73195164
90Progressive cerebellar ataxia (HP:0002073)1.72319172
91Excessive salivation (HP:0003781)1.71713941
92Asplenia (HP:0001746)1.71162496
93Severe muscular hypotonia (HP:0006829)1.70670264
94Abnormality of the pons (HP:0007361)1.69899693
95Narrow forehead (HP:0000341)1.68218057
96Aplasia/Hypoplasia of the uvula (HP:0010293)1.67643872
97Duplicated collecting system (HP:0000081)1.66478443
98Decreased electroretinogram (ERG) amplitude (HP:0000654)1.66365480
99Septo-optic dysplasia (HP:0100842)1.65904177
100Colon cancer (HP:0003003)1.64582234

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.10021391
2ADRBK23.63456736
3GRK12.94871301
4CASK2.84115596
5MAP3K42.72414408
6WNK32.67966871
7BMPR1B2.61408752
8TAOK32.41767302
9MAPK132.35188126
10TLK12.28765425
11MAP4K22.24896329
12MARK12.19421767
13ZAK2.17035575
14WNK42.12160839
15PINK12.00445418
16DAPK21.90073134
17INSRR1.87745652
18NTRK31.84234932
19MAP2K71.75667505
20ACVR1B1.68279939
21PNCK1.66373617
22NUAK11.65206561
23STK391.47035326
24TNIK1.43547161
25MKNK21.35786131
26OXSR11.35231296
27DYRK21.34397805
28TIE11.26616655
29PAK31.25727295
30NTRK21.24317125
31PHKG21.17924336
32PHKG11.17924336
33BCKDK1.08884261
34PRKCG1.07858968
35ADRBK11.06730295
36FGFR21.06442760
37TXK1.05441574
38MUSK1.04010555
39PRKCE0.97813981
40MAPKAPK50.93431449
41MAP2K40.91886151
42AKT30.89757124
43PLK20.84166853
44CAMKK20.79702080
45TGFBR10.76980858
46OBSCN0.74606270
47PIK3CA0.73039645
48BCR0.72503257
49VRK10.70347506
50TRIM280.69125004
51CSNK1G20.67991196
52CSNK1G10.67792515
53CAMK2A0.67209337
54STK38L0.67087769
55STK160.63939571
56MKNK10.63610669
57PLK40.59674538
58PTK2B0.59548163
59CAMK10.59534546
60PKN10.59412337
61MAPKAPK30.58944768
62MAPK150.58927257
63PRKACA0.56846754
64PRKAA10.56090153
65RPS6KA50.54983134
66CAMK1D0.53994032
67CSNK1G30.53514241
68PRKCQ0.52421852
69PRKAA20.51580774
70ERBB20.50094383
71EPHA30.49035586
72TNK20.48749599
73PRKCI0.48606253
74BRSK20.48041510
75CSNK1A10.47235088
76CAMK40.45350823
77WEE10.44340216
78EPHA40.42775499
79MAP2K60.42252838
80DYRK1A0.41147816
81TEC0.40883236
82CSNK1A1L0.40515561
83SGK20.38276956
84CAMK1G0.37648375
85NLK0.36747394
86ERBB30.35880834
87DYRK30.35368132
88CAMK2D0.35244180
89PRKD20.34924367
90PRKG10.34796515
91PRKCA0.34152965
92STK110.33384046
93CAMK2B0.32145309
94IKBKB0.31183388
95SGK2230.31142245
96SGK4940.31142245
97CDK50.29560580
98PRKACB0.29536733
99FER0.29532558
100NME10.28302490

Predicted pathways (KEGG)

RankGene SetZ-score
1Linoleic acid metabolism_Homo sapiens_hsa005913.01391814
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.99436575
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.94713835
4Nicotine addiction_Homo sapiens_hsa050332.87620431
5Phototransduction_Homo sapiens_hsa047442.76733947
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.44215120
7Butanoate metabolism_Homo sapiens_hsa006502.38050877
8Oxidative phosphorylation_Homo sapiens_hsa001902.31237129
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.20328505
10Nitrogen metabolism_Homo sapiens_hsa009102.13758374
11Ether lipid metabolism_Homo sapiens_hsa005652.08747153
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.98317657
13Selenocompound metabolism_Homo sapiens_hsa004501.98188731
14Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.96932194
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.95245768
16Maturity onset diabetes of the young_Homo sapiens_hsa049501.91212851
17Tryptophan metabolism_Homo sapiens_hsa003801.89589495
18Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.82004181
19Parkinsons disease_Homo sapiens_hsa050121.79461823
20Taste transduction_Homo sapiens_hsa047421.62729458
21Morphine addiction_Homo sapiens_hsa050321.62723516
22Homologous recombination_Homo sapiens_hsa034401.57881611
23Basal transcription factors_Homo sapiens_hsa030221.54419319
24Protein export_Homo sapiens_hsa030601.53185533
25Fanconi anemia pathway_Homo sapiens_hsa034601.48084966
26Cardiac muscle contraction_Homo sapiens_hsa042601.48029809
27Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.44483321
28GABAergic synapse_Homo sapiens_hsa047271.36570908
29RNA polymerase_Homo sapiens_hsa030201.34207165
30Caffeine metabolism_Homo sapiens_hsa002321.31025333
31Olfactory transduction_Homo sapiens_hsa047401.26338757
32Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.24517024
33Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.22412181
34Regulation of autophagy_Homo sapiens_hsa041401.22364201
35Serotonergic synapse_Homo sapiens_hsa047261.20713253
36Circadian entrainment_Homo sapiens_hsa047131.19207215
37Glutamatergic synapse_Homo sapiens_hsa047241.15617027
38Primary bile acid biosynthesis_Homo sapiens_hsa001201.12038351
39Fat digestion and absorption_Homo sapiens_hsa049751.11118778
40Insulin secretion_Homo sapiens_hsa049111.09975627
41Huntingtons disease_Homo sapiens_hsa050161.09448234
42Arachidonic acid metabolism_Homo sapiens_hsa005901.07520810
43Alzheimers disease_Homo sapiens_hsa050101.06763204
44Peroxisome_Homo sapiens_hsa041461.05673379
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.05552634
46Steroid hormone biosynthesis_Homo sapiens_hsa001401.04558677
47Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.96246382
48ABC transporters_Homo sapiens_hsa020100.94869662
49Cocaine addiction_Homo sapiens_hsa050300.94075534
50Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.94036975
51Chemical carcinogenesis_Homo sapiens_hsa052040.93567217
52Mineral absorption_Homo sapiens_hsa049780.93056179
53Retinol metabolism_Homo sapiens_hsa008300.90330333
54Cyanoamino acid metabolism_Homo sapiens_hsa004600.89654674
55Propanoate metabolism_Homo sapiens_hsa006400.89216674
56Histidine metabolism_Homo sapiens_hsa003400.88440084
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86504234
58Dopaminergic synapse_Homo sapiens_hsa047280.84916738
59Ovarian steroidogenesis_Homo sapiens_hsa049130.81476227
60Collecting duct acid secretion_Homo sapiens_hsa049660.79932423
61RNA degradation_Homo sapiens_hsa030180.78447525
62Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.78005758
63Steroid biosynthesis_Homo sapiens_hsa001000.74359012
64Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73707970
65Amphetamine addiction_Homo sapiens_hsa050310.71558202
66Glycerolipid metabolism_Homo sapiens_hsa005610.68842406
67Calcium signaling pathway_Homo sapiens_hsa040200.66090979
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64217106
69Cholinergic synapse_Homo sapiens_hsa047250.63851050
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.58540465
71Salivary secretion_Homo sapiens_hsa049700.57887314
72Pentose and glucuronate interconversions_Homo sapiens_hsa000400.56329480
73beta-Alanine metabolism_Homo sapiens_hsa004100.55297794
74Intestinal immune network for IgA production_Homo sapiens_hsa046720.54739849
75Glycerophospholipid metabolism_Homo sapiens_hsa005640.53785417
76Metabolic pathways_Homo sapiens_hsa011000.53533278
77Alcoholism_Homo sapiens_hsa050340.53413131
78Sulfur metabolism_Homo sapiens_hsa009200.51904336
79Axon guidance_Homo sapiens_hsa043600.50564520
80cAMP signaling pathway_Homo sapiens_hsa040240.49185673
81Sulfur relay system_Homo sapiens_hsa041220.48477439
82Basal cell carcinoma_Homo sapiens_hsa052170.47142945
83Purine metabolism_Homo sapiens_hsa002300.45785906
84Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.45472560
85Ribosome_Homo sapiens_hsa030100.45002791
86Oxytocin signaling pathway_Homo sapiens_hsa049210.44532837
87Hedgehog signaling pathway_Homo sapiens_hsa043400.42419207
88One carbon pool by folate_Homo sapiens_hsa006700.42147100
89Dorso-ventral axis formation_Homo sapiens_hsa043200.40003106
90Synaptic vesicle cycle_Homo sapiens_hsa047210.39905212
91Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.35706037
92Circadian rhythm_Homo sapiens_hsa047100.35463544
93Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.34745885
94Long-term depression_Homo sapiens_hsa047300.33500462
95Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.32749502
96Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.31677903
97Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.30805271
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30610356
99Cysteine and methionine metabolism_Homo sapiens_hsa002700.30455761
100Vitamin digestion and absorption_Homo sapiens_hsa049770.28370406

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