PCDHGB5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1skin morphogenesis (GO:0043589)5.02927893
2cell adhesion mediated by integrin (GO:0033627)4.79125946
3locomotory exploration behavior (GO:0035641)4.78565202
4hemidesmosome assembly (GO:0031581)4.76214947
5protein heterotrimerization (GO:0070208)4.59587017
6endodermal cell differentiation (GO:0035987)4.51002707
7cell-substrate junction assembly (GO:0007044)4.33178217
8collagen fibril organization (GO:0030199)4.32027090
9regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.04911653
10Golgi transport vesicle coating (GO:0048200)4.03423261
11COPI coating of Golgi vesicle (GO:0048205)4.03423261
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.98637817
13vocalization behavior (GO:0071625)3.97710093
14chondrocyte proliferation (GO:0035988)3.96555009
15type B pancreatic cell proliferation (GO:0044342)3.89276520
16synaptic vesicle maturation (GO:0016188)3.87280015
17extracellular matrix assembly (GO:0085029)3.80654432
18dendrite morphogenesis (GO:0048813)3.78760245
19positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.76418991
20layer formation in cerebral cortex (GO:0021819)3.75362030
21regulation of short-term neuronal synaptic plasticity (GO:0048172)3.69167028
22sequestering of extracellular ligand from receptor (GO:0035581)3.69112582
23regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.68646021
24cell migration involved in heart development (GO:0060973)3.63484519
25bone trabecula formation (GO:0060346)3.62446805
26neuron cell-cell adhesion (GO:0007158)3.59217566
27exploration behavior (GO:0035640)3.59061157
28positive regulation of blood vessel endothelial cell migration (GO:0043536)3.56810708
29cell-substrate adherens junction assembly (GO:0007045)3.54905858
30focal adhesion assembly (GO:0048041)3.54905858
31adherens junction assembly (GO:0034333)3.52486476
32regulation of glutamate receptor signaling pathway (GO:1900449)3.51964166
33kidney mesenchyme development (GO:0072074)3.51923707
34basement membrane organization (GO:0071711)3.49491642
35endocardial cushion development (GO:0003197)3.48740127
36protein localization to endosome (GO:0036010)3.48495030
37vascular endothelial growth factor signaling pathway (GO:0038084)3.47417380
38cell communication by electrical coupling (GO:0010644)3.40340913
39substrate-dependent cell migration (GO:0006929)3.37975240
40planar cell polarity pathway involved in neural tube closure (GO:0090179)3.37018390
41cerebral cortex radially oriented cell migration (GO:0021799)3.36885460
42protein retention in ER lumen (GO:0006621)3.34640195
43maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.33438831
44cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.32662655
45postsynaptic membrane organization (GO:0001941)3.32441706
46ionotropic glutamate receptor signaling pathway (GO:0035235)3.32414268
47dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.31737986
48dendritic spine morphogenesis (GO:0060997)3.30079631
49protein localization to synapse (GO:0035418)3.27456736
50central nervous system projection neuron axonogenesis (GO:0021952)3.26584292
51establishment of nucleus localization (GO:0040023)3.24916717
52positive regulation of endothelial cell apoptotic process (GO:2000353)3.23717918
53cellular response to vitamin (GO:0071295)3.23612993
54regulation of synapse structural plasticity (GO:0051823)3.23292673
55collagen metabolic process (GO:0032963)3.21766235
56innervation (GO:0060384)3.20842033
57heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.19224576
58synaptic transmission, glutamatergic (GO:0035249)3.18596614
59mesenchymal-epithelial cell signaling (GO:0060638)3.17453191
60regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.16062415
61desmosome organization (GO:0002934)3.15502918
62pyrimidine nucleobase catabolic process (GO:0006208)3.14563399
63virion attachment to host cell (GO:0019062)3.13222158
64adhesion of symbiont to host cell (GO:0044650)3.13222158
65regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.10136937
66membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.08761036
67negative regulation of fatty acid transport (GO:2000192)3.08617084
68regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.08451538
69regulation of long-term neuronal synaptic plasticity (GO:0048169)3.07394627
70hypotonic response (GO:0006971)3.07364723
71cell migration involved in sprouting angiogenesis (GO:0002042)3.05369140
72positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.04607174
73collagen catabolic process (GO:0030574)3.04156896
74negative regulation of smooth muscle cell migration (GO:0014912)3.04092909
75extracellular matrix disassembly (GO:0022617)3.02522699
76glutamate receptor signaling pathway (GO:0007215)3.02450644
77negative regulation of axon extension involved in axon guidance (GO:0048843)2.98453660
78wound healing, spreading of epidermal cells (GO:0035313)2.96973062
79multicellular organismal macromolecule metabolic process (GO:0044259)2.96952320
80regulation of axon extension involved in axon guidance (GO:0048841)2.96517846
81negative regulation of chondrocyte differentiation (GO:0032331)2.95828980
82glomerular basement membrane development (GO:0032836)2.95651743
83regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.95290485
84neurotransmitter-gated ion channel clustering (GO:0072578)2.93664635
85response to auditory stimulus (GO:0010996)2.93416496
86positive regulation of osteoblast proliferation (GO:0033690)2.92910755
87response to pheromone (GO:0019236)2.92335956
88regulation of synaptic vesicle exocytosis (GO:2000300)2.92219384
89regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.91298538
90axonal fasciculation (GO:0007413)2.90769080
91neuron recognition (GO:0008038)2.90380965
92auditory behavior (GO:0031223)2.90175562
93endothelial cell morphogenesis (GO:0001886)2.89581923
94mesodermal cell differentiation (GO:0048333)2.89280586
95barbed-end actin filament capping (GO:0051016)2.86532679
96adhesion of symbiont to host (GO:0044406)2.86268381
97cell migration in hindbrain (GO:0021535)2.84790949
98vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.84625129
99* homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.84275770
100stress fiber assembly (GO:0043149)2.84123054
101cellular response to vitamin D (GO:0071305)2.83521719
102metanephric mesenchyme development (GO:0072075)2.82752795
103semaphorin-plexin signaling pathway (GO:0071526)2.80926881
104multicellular organismal metabolic process (GO:0044236)2.80729629
105blood vessel maturation (GO:0001955)2.80454509
106regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.78477050
107synaptic vesicle docking involved in exocytosis (GO:0016081)2.76932972
108multicellular organismal catabolic process (GO:0044243)2.73944471
109apoptotic cell clearance (GO:0043277)2.73649522
110prepulse inhibition (GO:0060134)2.73351304
111extracellular matrix organization (GO:0030198)2.73314186
112synapse assembly (GO:0007416)2.72551337
113extracellular structure organization (GO:0043062)2.72262257
114regulation of neuronal synaptic plasticity (GO:0048168)2.71974121
115neuron-neuron synaptic transmission (GO:0007270)2.71816166
116regulation of NFAT protein import into nucleus (GO:0051532)2.71468963
117retina vasculature morphogenesis in camera-type eye (GO:0061299)2.71424460
118wound healing, spreading of cells (GO:0044319)2.70724222
119venous blood vessel morphogenesis (GO:0048845)2.70350954
120atrioventricular valve morphogenesis (GO:0003181)2.69991460
121muscle cell migration (GO:0014812)2.68554007
122regulation of extracellular matrix disassembly (GO:0010715)2.68053653
123glutamate secretion (GO:0014047)2.67887730
124heparan sulfate proteoglycan metabolic process (GO:0030201)2.67525483
125glial cell proliferation (GO:0014009)2.66971699
126axon extension involved in axon guidance (GO:0048846)2.66967128
127neuron projection extension involved in neuron projection guidance (GO:1902284)2.66967128
128negative regulation of osteoblast proliferation (GO:0033689)2.66447391
129epithelial cell-cell adhesion (GO:0090136)2.66263892
130fibroblast migration (GO:0010761)2.65669166
131cardiac myofibril assembly (GO:0055003)2.65446298
132paraxial mesoderm development (GO:0048339)2.64434052
133extracellular fibril organization (GO:0043206)2.63886793
134axon extension (GO:0048675)2.63823008
135Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.63759033
136cerebellar granule cell differentiation (GO:0021707)2.63654715
137negative regulation of adherens junction organization (GO:1903392)2.63444709
138negative regulation of focal adhesion assembly (GO:0051895)2.63444709
139negative regulation of cell junction assembly (GO:1901889)2.63444709
140COPII vesicle coating (GO:0048208)2.63369645
141positive regulation of endothelial cell migration (GO:0010595)2.62711430
142calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.62239317
143retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.61805068
144nucleus localization (GO:0051647)2.61556714
145cytoskeletal anchoring at plasma membrane (GO:0007016)2.61128327
146chondrocyte development (GO:0002063)2.59208564
147synaptic vesicle exocytosis (GO:0016079)2.58670639
148regulation of synaptic vesicle transport (GO:1902803)2.57921008
149substrate adhesion-dependent cell spreading (GO:0034446)2.57832919
150mitochondrion transport along microtubule (GO:0047497)2.57257267
151establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.57257267
152G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.56405210
153positive regulation of axon extension (GO:0045773)2.56248186
154regulation of axon guidance (GO:1902667)2.55930297
155regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.55624260
156substrate-independent telencephalic tangential migration (GO:0021826)2.55048978
157substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.55048978
158negative regulation of stem cell proliferation (GO:2000647)2.54636910
159regulation of establishment of planar polarity (GO:0090175)2.54188411
160pericardium development (GO:0060039)2.53715630
161dermatan sulfate biosynthetic process (GO:0030208)2.53678616
162negative regulation of sodium ion transport (GO:0010766)2.53650244
163positive regulation of synapse maturation (GO:0090129)2.52906661
164positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.51513134
165proline transport (GO:0015824)2.48660130
166presynaptic membrane assembly (GO:0097105)2.48131971
167central nervous system neuron axonogenesis (GO:0021955)2.47321892
168sodium ion export (GO:0071436)2.46462857
169long-term memory (GO:0007616)2.44413213
170cell communication involved in cardiac conduction (GO:0086065)2.42378496
171regulation of excitatory postsynaptic membrane potential (GO:0060079)2.40875923
172negative regulation of synaptic transmission, GABAergic (GO:0032229)2.40666695
173negative regulation of oligodendrocyte differentiation (GO:0048715)2.40143585
174gamma-aminobutyric acid transport (GO:0015812)2.39797467
175activation of protein kinase A activity (GO:0034199)2.39712268
176neuromuscular process controlling balance (GO:0050885)2.39612790
177negative regulation of cytosolic calcium ion concentration (GO:0051481)2.39558111
178establishment of mitochondrion localization (GO:0051654)2.39376436
179dermatan sulfate metabolic process (GO:0030205)2.37669837
180neuron projection morphogenesis (GO:0048812)2.36845700
181cellular potassium ion homeostasis (GO:0030007)2.36603733
182regulation of postsynaptic membrane potential (GO:0060078)2.36244945
183synapse organization (GO:0050808)2.36167383
184synaptic vesicle endocytosis (GO:0048488)2.36028858
185nucleobase catabolic process (GO:0046113)2.35135623
186regulation of synaptic transmission, glutamatergic (GO:0051966)2.34913126
187regulation of dendritic spine morphogenesis (GO:0061001)2.33388920
188dendritic spine organization (GO:0097061)2.30561128
189peripheral nervous system axon ensheathment (GO:0032292)2.29768139
190myelination in peripheral nervous system (GO:0022011)2.29768139
191cerebellar Purkinje cell differentiation (GO:0021702)2.29464660
192regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.29374480
193camera-type eye morphogenesis (GO:0048593)2.28767686
194positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.28357540
195regulation of cAMP-dependent protein kinase activity (GO:2000479)2.28181872
196chondroitin sulfate catabolic process (GO:0030207)2.28011372
197insulin-like growth factor receptor signaling pathway (GO:0048009)2.27761639

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.50290590
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.08724437
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.87037634
4GBX2_23144817_ChIP-Seq_PC3_Human3.83743043
5EZH2_22144423_ChIP-Seq_EOC_Human3.80178322
6PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.73179501
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.88097807
8ESR2_21235772_ChIP-Seq_MCF-7_Human2.82976742
9ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.68101560
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.65923996
11RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.54793983
12TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.52945008
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.48513237
14JARID2_20064375_ChIP-Seq_MESCs_Mouse2.45331750
15* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.44856759
16DROSHA_22980978_ChIP-Seq_HELA_Human2.34408028
17TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.28612881
18RNF2_18974828_ChIP-Seq_MESCs_Mouse2.26448083
19EZH2_18974828_ChIP-Seq_MESCs_Mouse2.26448083
20CLOCK_20551151_ChIP-Seq_293T_Human2.22067670
21BRD4_25478319_ChIP-Seq_HGPS_Human2.22012023
22* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.20387163
23EZH2_27304074_Chip-Seq_ESCs_Mouse2.16761515
24* EED_16625203_ChIP-ChIP_MESCs_Mouse2.15398261
25ELK3_25401928_ChIP-Seq_HUVEC_Human2.13938462
26ESR1_21235772_ChIP-Seq_MCF-7_Human2.12374084
27JARID2_20075857_ChIP-Seq_MESCs_Mouse2.09946502
28SALL1_21062744_ChIP-ChIP_HESCs_Human2.09882683
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.06550823
30* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.05305283
31AR_21572438_ChIP-Seq_LNCaP_Human2.04938667
32SMAD_19615063_ChIP-ChIP_OVARY_Human2.00787216
33TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.99353388
34SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.96520850
35STAT6_21828071_ChIP-Seq_BEAS2B_Human1.95116482
36* RNF2_27304074_Chip-Seq_ESCs_Mouse1.94345429
37WT1_19549856_ChIP-ChIP_CCG9911_Human1.94257589
38CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.93455860
39* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.91680614
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.90621406
41CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.88785352
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.87538733
43HIF1A_21447827_ChIP-Seq_MCF-7_Human1.85981413
44CJUN_26792858_Chip-Seq_BT549_Human1.84723762
45TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.80744119
46* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.79816311
47* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.79629329
48* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.79629329
49P300_27058665_Chip-Seq_ZR-75-30cells_Human1.79468502
50* EZH2_27294783_Chip-Seq_ESCs_Mouse1.78076508
51SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.75652913
52KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.75098840
53SOX9_24532713_ChIP-Seq_HFSC_Mouse1.71828693
54SMAD4_21799915_ChIP-Seq_A2780_Human1.71488110
55REST_21632747_ChIP-Seq_MESCs_Mouse1.70142904
56THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.69007246
57* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.66627580
58* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.64499256
59TP53_22127205_ChIP-Seq_IMR90_Human1.63019244
60RACK7_27058665_Chip-Seq_MCF-7_Human1.62646571
61ESR1_20079471_ChIP-ChIP_T-47D_Human1.60326900
62ZNF217_24962896_ChIP-Seq_MCF-7_Human1.60142682
63PIAS1_25552417_ChIP-Seq_VCAP_Human1.58121591
64GATA2_21666600_ChIP-Seq_HMVEC_Human1.56676754
65UBF1/2_26484160_Chip-Seq_HMECs_Human1.56094741
66RBPJ_22232070_ChIP-Seq_NCS_Mouse1.54698612
67CTBP2_25329375_ChIP-Seq_LNCAP_Human1.53332115
68SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.52530083
69* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.52485803
70VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.51717753
71CDX2_19796622_ChIP-Seq_MESCs_Mouse1.51221481
72P300_19829295_ChIP-Seq_ESCs_Human1.51090282
73EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48460051
74CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.48413179
75AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.47332984
76ZFP57_27257070_Chip-Seq_ESCs_Mouse1.43991157
77STAT3_23295773_ChIP-Seq_U87_Human1.43659280
78AHR_22903824_ChIP-Seq_MCF-7_Human1.43053517
79RARB_27405468_Chip-Seq_BRAIN_Mouse1.42934058
80ZNF263_19887448_ChIP-Seq_K562_Human1.42353259
81PPAR_26484153_Chip-Seq_NCI-H1993_Human1.41894242
82* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.41082848
83TBX20_22080862_ChIP-Seq_HEART_Mouse1.37809224
84TBX20_22328084_ChIP-Seq_HEART_Mouse1.37809224
85SMC1_22415368_ChIP-Seq_MEFs_Mouse1.37701438
86SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37224984
87SMAD3_21741376_ChIP-Seq_EPCs_Human1.37189486
88ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.37118578
89SOX2_21211035_ChIP-Seq_LN229_Gbm1.35555023
90ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.35335781
91ARNT_22903824_ChIP-Seq_MCF-7_Human1.35168215
92* TP53_23651856_ChIP-Seq_MEFs_Mouse1.34986678
93EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.34967880
94UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.34818219
95KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.34767600
96YAP1_20516196_ChIP-Seq_MESCs_Mouse1.32945083
97MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.32077354
98SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31234046
99TP53_20018659_ChIP-ChIP_R1E_Mouse1.31065643
100NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.30824236
101NRF2_20460467_ChIP-Seq_MEFs_Mouse1.30824236
102KDM2B_26808549_Chip-Seq_K562_Human1.30444020
103AR_19668381_ChIP-Seq_PC3_Human1.30296726
104KDM2B_26808549_Chip-Seq_SUP-B15_Human1.29314224
105WT1_25993318_ChIP-Seq_PODOCYTE_Human1.29292713
106POU3F2_20337985_ChIP-ChIP_501MEL_Human1.28603951
107OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28248073
108NFIB_24661679_ChIP-Seq_LUNG_Mouse1.27886198
109EP300_21415370_ChIP-Seq_HL-1_Mouse1.26920576
110ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.25487886
111TCF4_23295773_ChIP-Seq_U87_Human1.24940294
112LXR_22292898_ChIP-Seq_THP-1_Human1.24849832
113ZFP281_18757296_ChIP-ChIP_E14_Mouse1.24541540
114CTNNB1_20460455_ChIP-Seq_HCT116_Human1.24517254
115ZNF274_21170338_ChIP-Seq_K562_Hela1.22908295
116TAF15_26573619_Chip-Seq_HEK293_Human1.22606952
117NR3C1_23031785_ChIP-Seq_PC12_Mouse1.22469138
118TCF4_18268006_ChIP-ChIP_LS174T_Human1.22231166
119WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.21805604
120JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.21573988
121GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20370519
122TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.20253228
123TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.19958742
124RING1B_27294783_Chip-Seq_ESCs_Mouse1.19658045
125NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18719785
126CBX2_27304074_Chip-Seq_ESCs_Mouse1.18372421
127NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.16864646
128P63_26484246_Chip-Seq_KERATINOCYTES_Human1.16853069
129ESR1_15608294_ChIP-ChIP_MCF-7_Human1.16492398
130ZFP281_27345836_Chip-Seq_ESCs_Mouse1.16299684
131DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.16173575
132AR_25329375_ChIP-Seq_VCAP_Human1.15023383
133HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.13961931
134ATF3_27146783_Chip-Seq_COLON_Human1.13602270
135ERG_21242973_ChIP-ChIP_JURKAT_Human1.13253139
136SMC3_22415368_ChIP-Seq_MEFs_Mouse1.12876607
137* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.12629518
138TP53_18474530_ChIP-ChIP_U2OS_Human1.12619742
139RING1B_27294783_Chip-Seq_NPCs_Mouse1.12348807
140TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.12241815
141TET1_21490601_ChIP-Seq_MESCs_Mouse1.11661466
142TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11060090
143TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10941401
144MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.10803655
145REST_18959480_ChIP-ChIP_MESCs_Mouse1.10175837
146RXR_22108803_ChIP-Seq_LS180_Human1.09957341
147SMAD3_21741376_ChIP-Seq_HESCs_Human1.09905998
148CTBP1_25329375_ChIP-Seq_LNCAP_Human1.08508603
149RUNX2_22187159_ChIP-Seq_PCA_Human1.08439663
150NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.08228026
151TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07779239
152POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07779239
153P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07309885
154TP53_16413492_ChIP-PET_HCT116_Human1.07124307
155SMAD4_21741376_ChIP-Seq_HESCs_Human1.06221900
156TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05790972
157JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04979909
158CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03766515
159ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.02592205
160ER_23166858_ChIP-Seq_MCF-7_Human1.01950830
161SA1_22415368_ChIP-Seq_MEFs_Mouse1.01852690
162EGR1_19374776_ChIP-ChIP_THP-1_Human1.01218345
163UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00711773
164HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.98175811
165ISL1_27105846_Chip-Seq_CPCs_Mouse0.97673509
166BCAT_22108803_ChIP-Seq_LS180_Human0.97382141
167TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97190458
168NANOG_18555785_Chip-Seq_ESCs_Mouse0.96880390
169SMAD3_21741376_ChIP-Seq_ESCs_Human0.96308914
170SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.96074053

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog5.24927360
2MP0004859_abnormal_synaptic_plasticity4.48754190
3MP0004272_abnormal_basement_membrane3.85935118
4MP0005275_abnormal_skin_tensile3.68575073
5MP0000569_abnormal_digit_pigmentation3.65322215
6MP0003279_aneurysm3.49041100
7MP0003566_abnormal_cell_adhesion3.20145444
8MP0003635_abnormal_synaptic_transmissio2.71063702
9MP0000778_abnormal_nervous_system2.63546506
10MP0004270_analgesia2.52241425
11MP0009384_cardiac_valve_regurgitation2.46455595
12MP0010368_abnormal_lymphatic_system2.37790607
13MP0005248_abnormal_Harderian_gland2.37636101
14MP0009780_abnormal_chondrocyte_physiolo2.36955755
15MP0002063_abnormal_learning/memory/cond2.27949986
16MP0003950_abnormal_plasma_membrane2.16759653
17MP0001486_abnormal_startle_reflex2.14069693
18MP0002877_abnormal_melanocyte_morpholog2.00825589
19MP0005423_abnormal_somatic_nervous2.00587974
20MP0004858_abnormal_nervous_system2.00374980
21MP0002060_abnormal_skin_morphology1.93173539
22MP0000767_abnormal_smooth_muscle1.91634111
23MP0005023_abnormal_wound_healing1.89868076
24MP0006054_spinal_hemorrhage1.89454803
25MP0001542_abnormal_bone_strength1.89160633
26MP0005645_abnormal_hypothalamus_physiol1.87607708
27MP0001968_abnormal_touch/_nociception1.85928638
28MP0009745_abnormal_behavioral_response1.85532503
29MP0010352_gastrointestinal_tract_polyps1.80352283
30MP0009046_muscle_twitch1.78954819
31MP0003880_abnormal_central_pattern1.78889481
32MP0010030_abnormal_orbit_morphology1.78139729
33MP0003941_abnormal_skin_development1.75033660
34MP0005646_abnormal_pituitary_gland1.74262095
35MP0002572_abnormal_emotion/affect_behav1.72360756
36MP0003787_abnormal_imprinting1.69737643
37MP0002734_abnormal_mechanical_nocicepti1.66834346
38MP0005508_abnormal_skeleton_morphology1.66043415
39MP0002184_abnormal_innervation1.61806375
40MP0002736_abnormal_nociception_after1.61133667
41MP0002064_seizures1.59120635
42MP0002896_abnormal_bone_mineralization1.57113686
43MP0002557_abnormal_social/conspecific_i1.56534695
44MP0001299_abnormal_eye_distance/1.53621254
45MP0002295_abnormal_pulmonary_circulatio1.50062682
46MP0004811_abnormal_neuron_physiology1.48195859
47MP0004215_abnormal_myocardial_fiber1.45348264
48MP0000013_abnormal_adipose_tissue1.45164355
49MP0000566_synostosis1.41899541
50MP0001849_ear_inflammation1.41182313
51MP0003385_abnormal_body_wall1.40359512
52MP0009053_abnormal_anal_canal1.40341352
53MP0000955_abnormal_spinal_cord1.40289159
54MP0004885_abnormal_endolymph1.39487645
55MP0001346_abnormal_lacrimal_gland1.39225933
56MP0001502_abnormal_circadian_rhythm1.38819859
57MP0005386_behavior/neurological_phenoty1.38307040
58MP0004924_abnormal_behavior1.38307040
59MP0002067_abnormal_sensory_capabilities1.37453567
60MP0000751_myopathy1.35219599
61MP0000762_abnormal_tongue_morphology1.33639034
62MP0001348_abnormal_lacrimal_gland1.33194807
63MP0002735_abnormal_chemical_nociception1.31904669
64MP0001243_abnormal_dermal_layer1.31581311
65MP0001440_abnormal_grooming_behavior1.29779486
66MP0000631_abnormal_neuroendocrine_gland1.28376931
67MP0002882_abnormal_neuron_morphology1.26896683
68MP0005257_abnormal_intraocular_pressure1.24800981
69MP0008569_lethality_at_weaning1.24479757
70MP0001958_emphysema1.23429104
71MP0004510_myositis1.22918109
72MP0001177_atelectasis1.22497343
73MP0000462_abnormal_digestive_system1.22171547
74MP0005595_abnormal_vascular_smooth1.21371467
75MP0009250_abnormal_appendicular_skeleto1.18881623
76MP0002152_abnormal_brain_morphology1.17035148
77MP0005503_abnormal_tendon_morphology1.15374790
78MP0005409_darkened_coat_color1.14723778
79MP0005171_absent_coat_pigmentation1.13541859
80MP0003634_abnormal_glial_cell1.13037889
81MP0000534_abnormal_ureter_morphology1.12376188
82MP0000579_abnormal_nail_morphology1.11362227
83MP0003861_abnormal_nervous_system1.11007279
84MP0002254_reproductive_system_inflammat1.10203618
85MP0002733_abnormal_thermal_nociception1.10015660
86MP0002272_abnormal_nervous_system1.09238546
87MP0004233_abnormal_muscle_weight1.08223618
88MP0000467_abnormal_esophagus_morphology1.07538721
89MP0003045_fibrosis1.04594380
90MP0008775_abnormal_heart_ventricle1.03406324
91MP0000733_abnormal_muscle_development1.03404298
92MP0003191_abnormal_cellular_cholesterol1.03007318
93MP0005623_abnormal_meninges_morphology1.02945056
94MP0003122_maternal_imprinting1.02497807
95MP0003755_abnormal_palate_morphology1.02387891
96MP0000537_abnormal_urethra_morphology1.01100639
97MP0002796_impaired_skin_barrier1.00364762
98MP0004084_abnormal_cardiac_muscle0.98048729
99MP0003935_abnormal_craniofacial_develop0.97928098
100MP0003283_abnormal_digestive_organ0.97805531
101MP0001879_abnormal_lymphatic_vessel0.97795579
102MP0001188_hyperpigmentation0.97558496
103MP0005076_abnormal_cell_differentiation0.97285489
104MP0003115_abnormal_respiratory_system0.96689968
105MP0005197_abnormal_uvea_morphology0.94138728
106MP0002066_abnormal_motor_capabilities/c0.93945764
107MP0002909_abnormal_adrenal_gland0.93813158
108MP0010386_abnormal_urinary_bladder0.92909705
109MP0004134_abnormal_chest_morphology0.92564632
110MP0001970_abnormal_pain_threshold0.91838556
111MP0002116_abnormal_craniofacial_bone0.91751157
112MP0000003_abnormal_adipose_tissue0.91115128
113MP0003183_abnormal_peptide_metabolism0.90781569
114MP0003137_abnormal_impulse_conducting0.90572340
115MP0009840_abnormal_foam_cell0.90564772
116MP0005551_abnormal_eye_electrophysiolog0.90162075
117MP0004085_abnormal_heartbeat0.89737454
118MP0008438_abnormal_cutaneous_collagen0.89558146
119MP0003300_gastrointestinal_ulcer0.89457154
120MP0000428_abnormal_craniofacial_morphol0.89097377
121MP0004130_abnormal_muscle_cell0.87872542
122MP0004484_altered_response_of0.87206220
123MP0000759_abnormal_skeletal_muscle0.86924824
124MP0000538_abnormal_urinary_bladder0.85227628
125MP0005187_abnormal_penis_morphology0.85153852
126MP0005390_skeleton_phenotype0.84820748
127MP0003091_abnormal_cell_migration0.84495310
128MP0002233_abnormal_nose_morphology0.83838097
129MP0002108_abnormal_muscle_morphology0.83209099
130MP0000432_abnormal_head_morphology0.82989647
131MP0005164_abnormal_response_to0.82358934
132MP0000163_abnormal_cartilage_morphology0.82076360
133MP0002234_abnormal_pharynx_morphology0.81207831
134MP0001915_intracranial_hemorrhage0.81129868
135MP0002168_other_aberrant_phenotype0.80952586
136MP0002249_abnormal_larynx_morphology0.79233678
137MP0003938_abnormal_ear_development0.79053433
138MP0003942_abnormal_urinary_system0.78199868
139MP0002128_abnormal_blood_circulation0.78108257
140MP0004145_abnormal_muscle_electrophysio0.78052985
141MP0000749_muscle_degeneration0.77173209
142MP0003633_abnormal_nervous_system0.75980264
143MP0003121_genomic_imprinting0.75456324
144MP0000049_abnormal_middle_ear0.74620292
145MP0001614_abnormal_blood_vessel0.74245801
146MP0005501_abnormal_skin_physiology0.73065640
147MP0003690_abnormal_glial_cell0.72182804
148MP0002752_abnormal_somatic_nervous0.72080536
149MP0008961_abnormal_basal_metabolism0.71858012
150MP0002089_abnormal_postnatal_growth/wei0.71211134
151MP0003448_altered_tumor_morphology0.71119386
152MP0002081_perinatal_lethality0.70927559
153MP0000750_abnormal_muscle_regeneration0.70593869
154MP0003453_abnormal_keratinocyte_physiol0.70427225
155MP0002932_abnormal_joint_morphology0.68851281
156MP0002177_abnormal_outer_ear0.68562291
157MP0006138_congestive_heart_failure0.67560589
158MP0002115_abnormal_skeleton_extremities0.67434929
159MP0010771_integument_phenotype0.67423067
160MP0002113_abnormal_skeleton_development0.67422308
161MP0002925_abnormal_cardiovascular_devel0.66347913
162MP0000627_abnormal_mammary_gland0.66341137
163MP0005621_abnormal_cell_physiology0.62958973
164MP0005193_abnormal_anterior_eye0.60332123
165MP0001216_abnormal_epidermal_layer0.59956575
166MP0005165_increased_susceptibility_to0.59575913
167MP0002282_abnormal_trachea_morphology0.58118502
168MP0002114_abnormal_axial_skeleton0.57434794
169MP0004087_abnormal_muscle_fiber0.57091919

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)6.74145901
2Protrusio acetabuli (HP:0003179)6.58122741
3Aortic aneurysm (HP:0004942)4.63308537
4Ankle contracture (HP:0006466)4.54162391
5Aortic dissection (HP:0002647)4.51505117
6Vascular tortuosity (HP:0004948)4.45719439
7Follicular hyperkeratosis (HP:0007502)4.17437998
8Atrophic scars (HP:0001075)4.11447748
9Spinal rigidity (HP:0003306)3.92931675
10Type 1 muscle fiber predominance (HP:0003803)3.85905854
11Bladder diverticulum (HP:0000015)3.62773860
12Abnormality of dentin (HP:0010299)3.47048543
13Fragile skin (HP:0001030)3.40465944
14Cervical subluxation (HP:0003308)3.39961671
15Soft skin (HP:0000977)3.37423000
16Wormian bones (HP:0002645)3.35708011
17Slender build (HP:0001533)3.26421427
18Short 4th metacarpal (HP:0010044)3.24406925
19Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.24406925
20Neonatal short-limb short stature (HP:0008921)3.15090202
21Mildly elevated creatine phosphokinase (HP:0008180)3.06852547
22Genu recurvatum (HP:0002816)3.05977807
23Genetic anticipation (HP:0003743)3.01053902
24Progressive cerebellar ataxia (HP:0002073)2.96943281
25Blue sclerae (HP:0000592)2.88092872
26Vertebral compression fractures (HP:0002953)2.87226952
27Spondylolisthesis (HP:0003302)2.85864643
28Aqueductal stenosis (HP:0002410)2.84315046
29Dilatation of the ascending aorta (HP:0005111)2.77090882
30Increased variability in muscle fiber diameter (HP:0003557)2.76766390
31Mitral valve prolapse (HP:0001634)2.70120173
32Joint laxity (HP:0001388)2.64768340
33Midline defect of the nose (HP:0004122)2.61627844
34Action tremor (HP:0002345)2.60712510
35Bowel diverticulosis (HP:0005222)2.59860392
36Broad metatarsal (HP:0001783)2.59150680
37Excessive salivation (HP:0003781)2.57678364
38Drooling (HP:0002307)2.57678364
39Mitral regurgitation (HP:0001653)2.56784727
40Aortic regurgitation (HP:0001659)2.55322296
41Focal seizures (HP:0007359)2.55107775
42Elbow flexion contracture (HP:0002987)2.54561945
43Epileptic encephalopathy (HP:0200134)2.54529320
44Cerebral aneurysm (HP:0004944)2.50844695
45Short nail (HP:0001799)2.49356673
46Prolonged QT interval (HP:0001657)2.47019713
47Biconcave vertebral bodies (HP:0004586)2.46662637
48Hypoventilation (HP:0002791)2.44203141
49Abnormality of the 4th metacarpal (HP:0010012)2.43343601
50Shallow orbits (HP:0000586)2.43232636
51Aneurysm (HP:0002617)2.40371628
52Urinary bladder sphincter dysfunction (HP:0002839)2.40177974
53Osteolytic defects of the phalanges of the hand (HP:0009771)2.38537752
54Osteolytic defects of the hand bones (HP:0009699)2.38537752
55Bundle branch block (HP:0011710)2.38247800
56Hyperextensible skin (HP:0000974)2.36227253
57Abnormality of skeletal muscle fiber size (HP:0012084)2.35742649
58Increased connective tissue (HP:0009025)2.32062729
59Distal upper limb amyotrophy (HP:0007149)2.30582109
60Upper limb amyotrophy (HP:0009129)2.30582109
61Natal tooth (HP:0000695)2.29494643
62Ulnar bowing (HP:0003031)2.28827128
63Scanning speech (HP:0002168)2.24890246
64Hyperacusis (HP:0010780)2.24365403
65Long toe (HP:0010511)2.23373371
66Abnormality of the acetabulum (HP:0003170)2.23300988
67Aplasia involving bones of the upper limbs (HP:0009823)2.23122042
68Aplasia of the phalanges of the hand (HP:0009802)2.23122042
69Aplasia involving bones of the extremities (HP:0009825)2.23122042
70Achilles tendon contracture (HP:0001771)2.22256383
71Wrist flexion contracture (HP:0001239)2.21720523
72Wide anterior fontanel (HP:0000260)2.21018724
73Abnormality of the nasal septum (HP:0000419)2.17572974
74Peritonitis (HP:0002586)2.15930706
75Distal lower limb amyotrophy (HP:0008944)2.14522957
76Disproportionate tall stature (HP:0001519)2.10788311
77Distal lower limb muscle weakness (HP:0009053)2.09730285
78Generalized amyotrophy (HP:0003700)2.08834806
79Mitral stenosis (HP:0001718)2.08536458
80Papillary thyroid carcinoma (HP:0002895)2.06579470
81Focal motor seizures (HP:0011153)2.05314122
82Febrile seizures (HP:0002373)2.04477356
83Cutaneous finger syndactyly (HP:0010554)2.03976443
84Chronic hepatic failure (HP:0100626)2.02205894
85Congenital glaucoma (HP:0001087)2.02155878
86Asymmetry of the thorax (HP:0001555)2.01684399
87Lower limb amyotrophy (HP:0007210)1.99905386
88Obsessive-compulsive behavior (HP:0000722)1.99345276
89Cardiovascular calcification (HP:0011915)1.98906091
90Alacrima (HP:0000522)1.98257297
91Macroorchidism (HP:0000053)1.98160942
92Aortic valve stenosis (HP:0001650)1.98137444
93Myokymia (HP:0002411)1.96054080
94Abnormal delivery (HP:0001787)1.95711642
95Urinary urgency (HP:0000012)1.94372310
96Abnormality of the Achilles tendon (HP:0005109)1.94236672
97Hepatoblastoma (HP:0002884)1.92645418
98Decreased lacrimation (HP:0000633)1.92364897
99Coronal craniosynostosis (HP:0004440)1.92266665
100Renal duplication (HP:0000075)1.91885444
101Joint stiffness (HP:0001387)1.91626896
102Broad face (HP:0000283)1.91520290
103Mutism (HP:0002300)1.91225958
104Trigonocephaly (HP:0000243)1.90299718
105Dysdiadochokinesis (HP:0002075)1.89737334
106Round ear (HP:0100830)1.89280219
107Atrial fibrillation (HP:0005110)1.88030162
108Cutaneous syndactyly (HP:0012725)1.87616734
109Impaired vibration sensation in the lower limbs (HP:0002166)1.87589105
110Glioma (HP:0009733)1.86317179
111Hallux valgus (HP:0001822)1.86254906
112Camptodactyly of toe (HP:0001836)1.85921568
113Deviation of the hallux (HP:0010051)1.84854417
114Broad-based gait (HP:0002136)1.84360275
115Subacute progressive viral hepatitis (HP:0006572)1.84170468
116Supranuclear gaze palsy (HP:0000605)1.84087581
117Protruding ear (HP:0000411)1.83722646
118Syncope (HP:0001279)1.83253644
119Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.81550485
120Postural instability (HP:0002172)1.81451332
121Spinal cord lesions (HP:0100561)1.80629295
122Syringomyelia (HP:0003396)1.80629295
123Renovascular hypertension (HP:0100817)1.80165541
124Advanced eruption of teeth (HP:0006288)1.80009084
125Primary atrial arrhythmia (HP:0001692)1.79429619
126Buphthalmos (HP:0000557)1.78910534
127Uterine leiomyosarcoma (HP:0002891)1.78828431
128Leiomyosarcoma (HP:0100243)1.78828431
129Thin bony cortex (HP:0002753)1.78628348
130Open mouth (HP:0000194)1.78443385
131Limb-girdle muscle weakness (HP:0003325)1.77706483
132Anterior segment dysgenesis (HP:0007700)1.77223299
133Abnormality of the corticospinal tract (HP:0002492)1.76456726
134Abnormality of the parietal bone (HP:0002696)1.76297977
135Astrocytoma (HP:0009592)1.76280239
136Abnormality of the astrocytes (HP:0100707)1.76280239
137Inappropriate behavior (HP:0000719)1.75954593
138Mild short stature (HP:0003502)1.74270790
139Elfin facies (HP:0004428)1.73301397
140Knee flexion contracture (HP:0006380)1.72514465
141Abnormality of salivation (HP:0100755)1.72374427
142Abnormality of the distal phalanges of the toes (HP:0010182)1.71955649
143Papilledema (HP:0001085)1.71818848
144Abnormal EKG (HP:0003115)1.71681572
145Ovoid vertebral bodies (HP:0003300)1.71092532
146Meningioma (HP:0002858)1.70613944
147Hand muscle atrophy (HP:0009130)1.70508621
148Coxa vara (HP:0002812)1.70476884
149Gaze-evoked nystagmus (HP:0000640)1.70124073
150Ectopia lentis (HP:0001083)1.69456131
151Narrow palate (HP:0000189)1.68547487
152Relative macrocephaly (HP:0004482)1.68357943
153Abnormal ossification of hand bones (HP:0005921)1.67888031
154Stereotypic behavior (HP:0000733)1.67102302
155Bell-shaped thorax (HP:0001591)1.66658682
156Central scotoma (HP:0000603)1.66278125
157Pachygyria (HP:0001302)1.66228867
158Inguinal hernia (HP:0000023)1.65994771
159Protruding tongue (HP:0010808)1.65737557
160Neoplasm of the heart (HP:0100544)1.65502578
161Breech presentation (HP:0001623)1.65445733
162Visual hallucinations (HP:0002367)1.62264875
163Sudden death (HP:0001699)1.61731147
164Exotropia (HP:0000577)1.61508061
165Hydroureter (HP:0000072)1.60619186
166Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.60530330
167Bronchomalacia (HP:0002780)1.60006705
168Supraventricular tachycardia (HP:0004755)1.59575292
169Pointed chin (HP:0000307)1.59365043
170Tibial bowing (HP:0002982)1.59189466
171Abnormality of the umbilical cord (HP:0010881)1.58876662
172Supraventricular arrhythmia (HP:0005115)1.57477355
173Obstructive sleep apnea (HP:0002870)1.57194880
174Neoplasm of the peripheral nervous system (HP:0100007)1.56975035
175Ankle clonus (HP:0011448)1.55844965
176Transitional cell carcinoma of the bladder (HP:0006740)1.55200749
177Anophthalmia (HP:0000528)1.53929342
178Overgrowth (HP:0001548)1.53643912
179Lower limb muscle weakness (HP:0007340)1.52443266
180Aplasia/Hypoplasia of the brainstem (HP:0007362)1.52388484
181Hypoplasia of the brainstem (HP:0002365)1.52388484
182Flat cornea (HP:0007720)1.51351031
183Volvulus (HP:0002580)1.51050746
184Arterial tortuosity (HP:0005116)1.50865718
185Poor eye contact (HP:0000817)1.50627725
186Megalencephaly (HP:0001355)1.49713969
187Deep philtrum (HP:0002002)1.49357942
188Absent frontal sinuses (HP:0002688)1.47993162
189Deeply set eye (HP:0000490)1.47552147
190Narrow nasal bridge (HP:0000446)1.47532981
191Truncal ataxia (HP:0002078)1.46946625

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.66949472
2MYLK3.73409691
3TRIB33.70530028
4TTN3.25624355
5TNIK2.82798701
6PTK22.76600363
7NTRK32.56370432
8NTRK22.28359123
9PDGFRA2.19921906
10MAPK132.18691084
11PAK22.11815605
12PRKD32.06831693
13PAK62.03012488
14EPHA22.02036824
15NEK91.99199677
16PHKG11.94570073
17PHKG21.94570073
18KSR11.94035389
19DMPK1.92278363
20TESK11.90949082
21MET1.84902009
22LIMK11.82424299
23TGFBR21.79123370
24EPHB21.78787234
25ERN11.77968119
26PKN21.77390777
27PAK41.76338997
28SGK21.72621937
29PRPF4B1.67304688
30ERBB31.67135637
31ICK1.65990537
32CASK1.64604640
33MINK11.62979091
34LATS21.61169234
35SMG11.59792218
36CAMK1G1.54946254
37MAP3K121.48696745
38SGK31.42708291
39SCYL21.41824305
40MST1R1.37341252
41EEF2K1.34342037
42MAP3K91.33822112
43EPHA41.32930059
44CAMK1D1.30015323
45TRPM71.28536642
46DAPK21.25168394
47AKT31.24564512
48LATS11.23943605
49NEK61.22800618
50EPHB11.22030924
51ERBB41.20021471
52CAMKK11.18689082
53PRKCH1.16131490
54MAP3K41.15319826
55SGK2231.14123949
56SGK4941.14123949
57ROCK21.10285115
58PLK21.10085356
59PDGFRB1.09290441
60MAPKAPK31.07898623
61DYRK21.07479769
62CDK51.06633226
63BRD41.01493865
64PAK31.01379965
65FGFR20.97020520
66CDK120.93417879
67PKN10.93382239
68ERBB20.90627888
69ALK0.87874357
70SIK20.87081315
71FLT30.85162599
72STK380.83717456
73TIE10.83572105
74DYRK1A0.83443841
75MOS0.83232985
76MARK20.83026281
77CAMK40.82764614
78OBSCN0.82642289
79PRKG20.82601185
80PIK3CA0.82138732
81PIM20.81729848
82PIK3CG0.81718866
83IRAK30.80695195
84INSRR0.80315960
85CDC42BPA0.80150979
86STK240.79753114
87TAOK20.79706606
88MAP3K30.78955942
89ILK0.78557223
90GRK70.78118284
91MAP2K70.77934708
92RIPK10.77452461
93SGK10.77237412
94LMTK20.76963318
95ARAF0.73268921
96PTK60.73026157
97RPS6KA20.71210647
98RET0.71147710
99NTRK10.69992681
100MAP2K10.68329736
101ABL20.67528906
102PRKCG0.67257719
103ROCK10.66735842
104DAPK30.66660948
105MAP2K40.66407378
106FGFR40.66387410
107ZAK0.65766536
108YES10.64957445
109CAMK2G0.64433372
110SIK10.64377096
111PTK2B0.64074987
112STK110.62243267
113CDK80.60289260
114TYRO30.59610127
115EPHA30.58734646
116PRKCE0.56572834
117CSNK1D0.56485964
118MAP3K60.56186879
119CAMK2B0.56071465
120MELK0.55802185
121GRK50.55185479
122DDR20.54987763
123CAMK10.54573876
124RPS6KL10.53877411
125RPS6KC10.53877411
126SIK30.52959894
127CLK10.51930746
128PRKD10.51868801
129RPS6KA30.51665650
130ADRBK10.51653206
131PRKCZ0.50940552
132MAPK100.50828049
133CAMK2A0.50520608
134MTOR0.49827320
135FYN0.49580518
136MAPK80.49165657
137GSK3A0.48841886
138FER0.48073824
139PRKAA10.47676581
140EIF2AK20.47433641
141MAPK70.46766474
142GSK3B0.46509730
143MAPK120.46458825
144FGFR30.46020347
145PNCK0.45936480
146CSNK1G20.44594592
147KSR20.44045589
148FES0.42687634
149PRKD20.42561303
150DYRK1B0.42372597
151CAMKK20.41785505
152JAK10.41468694
153FGFR10.41406050
154WNK10.39372607
155PRKG10.39198295
156PDPK10.38670058
157CHUK0.38116805
158STK38L0.36709389
159RPS6KB20.34433467
160MAPKAPK20.34188724
161RPS6KA60.33769475
162CAMK2D0.32547013
163AKT20.28161534
164MAP3K70.28042615
165SRC0.28017593
166PAK10.27456629

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.52476635
2Circadian entrainment_Homo sapiens_hsa047132.05660270
3Glycosaminoglycan degradation_Homo sapiens_hsa005311.98905794
4Amoebiasis_Homo sapiens_hsa051461.88264486
5Olfactory transduction_Homo sapiens_hsa047401.85588011
6Bladder cancer_Homo sapiens_hsa052191.85232644
7Glutamatergic synapse_Homo sapiens_hsa047241.85117179
8Morphine addiction_Homo sapiens_hsa050321.83487085
9Small cell lung cancer_Homo sapiens_hsa052221.76438708
10GABAergic synapse_Homo sapiens_hsa047271.76091672
11Axon guidance_Homo sapiens_hsa043601.74529182
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.74389455
13Long-term potentiation_Homo sapiens_hsa047201.72600123
14Dilated cardiomyopathy_Homo sapiens_hsa054141.68054425
15Insulin secretion_Homo sapiens_hsa049111.66141423
16Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.59994842
17Glioma_Homo sapiens_hsa052141.54872424
18Cholinergic synapse_Homo sapiens_hsa047251.54084616
19Protein digestion and absorption_Homo sapiens_hsa049741.52817284
20Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.50826280
21Synaptic vesicle cycle_Homo sapiens_hsa047211.50373370
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.48314072
23Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.46488890
24Renin secretion_Homo sapiens_hsa049241.46169414
25Salivary secretion_Homo sapiens_hsa049701.46056083
26Dopaminergic synapse_Homo sapiens_hsa047281.45297846
27Amphetamine addiction_Homo sapiens_hsa050311.42475622
28Oxytocin signaling pathway_Homo sapiens_hsa049211.40927492
29Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.40286383
30Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.38974695
31Type II diabetes mellitus_Homo sapiens_hsa049301.38019332
32Gap junction_Homo sapiens_hsa045401.36718607
33Cocaine addiction_Homo sapiens_hsa050301.33986267
34Endometrial cancer_Homo sapiens_hsa052131.33116851
35PI3K-Akt signaling pathway_Homo sapiens_hsa041511.32637157
36ErbB signaling pathway_Homo sapiens_hsa040121.30407899
37Thyroid cancer_Homo sapiens_hsa052161.30292757
38Prion diseases_Homo sapiens_hsa050201.28629954
39Gastric acid secretion_Homo sapiens_hsa049711.28439118
40Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.27260684
41Thyroid hormone signaling pathway_Homo sapiens_hsa049191.26397764
42cAMP signaling pathway_Homo sapiens_hsa040241.25094847
43Long-term depression_Homo sapiens_hsa047301.23027801
44Calcium signaling pathway_Homo sapiens_hsa040201.22680899
45Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.22483726
46Basal cell carcinoma_Homo sapiens_hsa052171.21581116
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.21072464
48Melanogenesis_Homo sapiens_hsa049161.20655824
49Taste transduction_Homo sapiens_hsa047421.13989745
50cGMP-PKG signaling pathway_Homo sapiens_hsa040221.13931979
51Phototransduction_Homo sapiens_hsa047441.13826388
52GnRH signaling pathway_Homo sapiens_hsa049121.13397596
53Serotonergic synapse_Homo sapiens_hsa047261.13084049
54TGF-beta signaling pathway_Homo sapiens_hsa043501.11785004
55Estrogen signaling pathway_Homo sapiens_hsa049151.11461205
56Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.07712447
57Phosphatidylinositol signaling system_Homo sapiens_hsa040701.05072409
58Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.04931286
59Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.04872097
60Vibrio cholerae infection_Homo sapiens_hsa051101.04725756
61Phospholipase D signaling pathway_Homo sapiens_hsa040721.03198761
62Other glycan degradation_Homo sapiens_hsa005111.01145391
63Wnt signaling pathway_Homo sapiens_hsa043101.00242087
64Adherens junction_Homo sapiens_hsa045200.99765347
65Leukocyte transendothelial migration_Homo sapiens_hsa046700.97592603
66Choline metabolism in cancer_Homo sapiens_hsa052310.97513271
67Hippo signaling pathway_Homo sapiens_hsa043900.96243452
68Lysine degradation_Homo sapiens_hsa003100.95219807
69Renal cell carcinoma_Homo sapiens_hsa052110.92943221
70Notch signaling pathway_Homo sapiens_hsa043300.92816264
71Melanoma_Homo sapiens_hsa052180.91180376
72Hedgehog signaling pathway_Homo sapiens_hsa043400.89911895
73Focal adhesion_Homo sapiens_hsa045100.89734013
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.89657782
75Rap1 signaling pathway_Homo sapiens_hsa040150.89043147
76Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.89039450
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.88706791
78MicroRNAs in cancer_Homo sapiens_hsa052060.86439317
79MAPK signaling pathway_Homo sapiens_hsa040100.86257795
80Longevity regulating pathway - mammal_Homo sapiens_hsa042110.86002605
81Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.84785007
82N-Glycan biosynthesis_Homo sapiens_hsa005100.84204420
83VEGF signaling pathway_Homo sapiens_hsa043700.83074246
84Endocytosis_Homo sapiens_hsa041440.82253891
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.80909389
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.80906878
87Regulation of actin cytoskeleton_Homo sapiens_hsa048100.80426304
88Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.80329710
89Colorectal cancer_Homo sapiens_hsa052100.79949966
90Non-small cell lung cancer_Homo sapiens_hsa052230.79084455
91AMPK signaling pathway_Homo sapiens_hsa041520.78854128
92Dorso-ventral axis formation_Homo sapiens_hsa043200.77898479
93Shigellosis_Homo sapiens_hsa051310.76067631
94Ras signaling pathway_Homo sapiens_hsa040140.75967990
95Proteoglycans in cancer_Homo sapiens_hsa052050.75101373
96Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73362298
97Lysosome_Homo sapiens_hsa041420.73129955
98mTOR signaling pathway_Homo sapiens_hsa041500.72021959
99Acute myeloid leukemia_Homo sapiens_hsa052210.71993194
100Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.71246721
101Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69498316
102Viral myocarditis_Homo sapiens_hsa054160.69494070
103Central carbon metabolism in cancer_Homo sapiens_hsa052300.69231071
104Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.69081959
105Insulin signaling pathway_Homo sapiens_hsa049100.67574290
106Prostate cancer_Homo sapiens_hsa052150.66987888
107Chronic myeloid leukemia_Homo sapiens_hsa052200.66987493
108Circadian rhythm_Homo sapiens_hsa047100.64327150
109Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63385957
110Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.63304547
111Sphingolipid metabolism_Homo sapiens_hsa006000.63205877
112Chemokine signaling pathway_Homo sapiens_hsa040620.59991576
113Sphingolipid signaling pathway_Homo sapiens_hsa040710.59193152
114AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.58116501
115Complement and coagulation cascades_Homo sapiens_hsa046100.57825844
116Tight junction_Homo sapiens_hsa045300.57216312
117Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56904250
118Pentose phosphate pathway_Homo sapiens_hsa000300.56548261
119ECM-receptor interaction_Homo sapiens_hsa045120.55121065
120Prolactin signaling pathway_Homo sapiens_hsa049170.53967949
121Thyroid hormone synthesis_Homo sapiens_hsa049180.53885434
122Insulin resistance_Homo sapiens_hsa049310.53554294
123Inositol phosphate metabolism_Homo sapiens_hsa005620.53550410
124Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53368112
125Malaria_Homo sapiens_hsa051440.52579763
126Pathways in cancer_Homo sapiens_hsa052000.51509153
127Pancreatic cancer_Homo sapiens_hsa052120.50584003
128p53 signaling pathway_Homo sapiens_hsa041150.50495914
129Platelet activation_Homo sapiens_hsa046110.50290439
130Salmonella infection_Homo sapiens_hsa051320.49820378
131Hepatitis C_Homo sapiens_hsa051600.48125907
132TNF signaling pathway_Homo sapiens_hsa046680.45996275
133Glucagon signaling pathway_Homo sapiens_hsa049220.43968678
134Hepatitis B_Homo sapiens_hsa051610.42574999
135Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.42328898

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