PCDHGA6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1alkaloid metabolic process (GO:0009820)5.80711426
2serotonin metabolic process (GO:0042428)5.74907778
3indolalkylamine metabolic process (GO:0006586)5.37092489
4locomotory exploration behavior (GO:0035641)5.34859465
5behavioral response to nicotine (GO:0035095)5.33878189
6epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.24329295
7primary amino compound metabolic process (GO:1901160)5.23799855
8synaptic vesicle maturation (GO:0016188)5.14181263
9regulation of short-term neuronal synaptic plasticity (GO:0048172)5.04659404
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.91260838
11dopamine biosynthetic process (GO:0042416)4.90306135
12positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.75056428
13vocalization behavior (GO:0071625)4.63738832
14toxin metabolic process (GO:0009404)4.63079338
15synaptic vesicle docking involved in exocytosis (GO:0016081)4.53547176
16regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.49585421
17regulation of synapse structural plasticity (GO:0051823)4.30541335
18glutamate secretion (GO:0014047)4.21714785
19regulation of glutamate receptor signaling pathway (GO:1900449)4.13387549
20layer formation in cerebral cortex (GO:0021819)4.12190753
21response to insecticide (GO:0017085)4.11164992
22synaptic vesicle exocytosis (GO:0016079)4.02294733
23indole-containing compound metabolic process (GO:0042430)3.97422468
24regulation of long-term neuronal synaptic plasticity (GO:0048169)3.94634884
25regulation of synaptic vesicle exocytosis (GO:2000300)3.91822858
26dendritic spine morphogenesis (GO:0060997)3.91680326
27membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.88902926
28exploration behavior (GO:0035640)3.88098241
29detection of light stimulus involved in visual perception (GO:0050908)3.84002943
30detection of light stimulus involved in sensory perception (GO:0050962)3.84002943
31ionotropic glutamate receptor signaling pathway (GO:0035235)3.82105831
32neurotransmitter-gated ion channel clustering (GO:0072578)3.78942408
33gamma-aminobutyric acid transport (GO:0015812)3.78505424
34regulation of neuronal synaptic plasticity (GO:0048168)3.78284955
35mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.76275711
36neuron cell-cell adhesion (GO:0007158)3.74269613
37auditory behavior (GO:0031223)3.69240453
38protein localization to synapse (GO:0035418)3.67268062
39neurotransmitter secretion (GO:0007269)3.62087225
40platelet dense granule organization (GO:0060155)3.60305609
41cellular potassium ion homeostasis (GO:0030007)3.55777989
42response to auditory stimulus (GO:0010996)3.50800649
43cell communication by electrical coupling (GO:0010644)3.50038366
44protein-cofactor linkage (GO:0018065)3.49076492
45regulation of hippo signaling (GO:0035330)3.48455981
46positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.47696134
47epithelial cilium movement (GO:0003351)3.45692496
48cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.44727983
49glutamate receptor signaling pathway (GO:0007215)3.44564056
50synaptic transmission, glutamatergic (GO:0035249)3.44001141
51sodium ion export (GO:0071436)3.43491969
52activation of protein kinase A activity (GO:0034199)3.42953792
53long-term memory (GO:0007616)3.41522989
54regulation of synaptic vesicle transport (GO:1902803)3.40115606
55L-fucose catabolic process (GO:0042355)3.39213623
56fucose catabolic process (GO:0019317)3.39213623
57L-fucose metabolic process (GO:0042354)3.39213623
58positive regulation of synapse maturation (GO:0090129)3.38251773
59hindbrain development (GO:0030902)3.37897657
60regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.36862966
61dendrite morphogenesis (GO:0048813)3.36030152
62neuromuscular process controlling balance (GO:0050885)3.33057799
63proline transport (GO:0015824)3.31100214
64postsynaptic membrane organization (GO:0001941)3.30148310
65regulation of excitatory postsynaptic membrane potential (GO:0060079)3.28827805
66neuron recognition (GO:0008038)3.28779118
67energy coupled proton transport, down electrochemical gradient (GO:0015985)3.25925383
68ATP synthesis coupled proton transport (GO:0015986)3.25925383
69regulation of dendritic spine morphogenesis (GO:0061001)3.24240012
70neuronal action potential propagation (GO:0019227)3.24176760
71axonal fasciculation (GO:0007413)3.23921753
72negative regulation of telomere maintenance (GO:0032205)3.22636634
73water-soluble vitamin biosynthetic process (GO:0042364)3.21806840
74catechol-containing compound biosynthetic process (GO:0009713)3.19175218
75catecholamine biosynthetic process (GO:0042423)3.19175218
76positive regulation of membrane potential (GO:0045838)3.17750295
77positive regulation of synaptic transmission, GABAergic (GO:0032230)3.17195817
78DNA deamination (GO:0045006)3.16326523
79neuron-neuron synaptic transmission (GO:0007270)3.15009090
80prepulse inhibition (GO:0060134)3.14111750
81nephron tubule morphogenesis (GO:0072078)3.12830356
82nephron epithelium morphogenesis (GO:0072088)3.12830356
83regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.12623760
84innervation (GO:0060384)3.10389130
85kidney morphogenesis (GO:0060993)3.10077359
86regulation of postsynaptic membrane potential (GO:0060078)3.09144869
87kynurenine metabolic process (GO:0070189)3.06411838
88urinary tract smooth muscle contraction (GO:0014848)3.05728892
89histone H3-K9 methylation (GO:0051567)3.05055235
90neuronal action potential (GO:0019228)3.04560005
91establishment of nucleus localization (GO:0040023)3.04543933
92nonmotile primary cilium assembly (GO:0035058)3.03251711
93regulation of synaptic transmission, glutamatergic (GO:0051966)3.00923611
94multicellular organismal aging (GO:0010259)3.00815651
95indole-containing compound catabolic process (GO:0042436)3.00115937
96indolalkylamine catabolic process (GO:0046218)3.00115937
97tryptophan catabolic process (GO:0006569)3.00115937
98positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.98551086
99cornea development in camera-type eye (GO:0061303)2.98312915
100negative regulation of cytosolic calcium ion concentration (GO:0051481)2.97171873
101regulation of action potential (GO:0098900)2.96823585
102regulation of synaptic plasticity (GO:0048167)2.96004775
103cellular ketone body metabolic process (GO:0046950)2.95991334
104negative regulation of synaptic transmission, GABAergic (GO:0032229)2.94892163
105RNA destabilization (GO:0050779)2.94838851
106glycine transport (GO:0015816)2.94544480
107peristalsis (GO:0030432)2.92735075
108potassium ion import (GO:0010107)2.92602622
109G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.91807402
110pyrimidine nucleobase catabolic process (GO:0006208)2.91685275
111detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.90561420
112cerebellar granule cell differentiation (GO:0021707)2.90138563
113cerebellar Purkinje cell differentiation (GO:0021702)2.89719721
114regulation of cilium movement (GO:0003352)2.89600417
115regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.89555505
116L-amino acid import (GO:0043092)2.88450788
117regulation of vesicle fusion (GO:0031338)2.86503170
118synapse assembly (GO:0007416)2.86377653
119positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.85644409
120regulation of rhodopsin mediated signaling pathway (GO:0022400)2.83838406
121membrane hyperpolarization (GO:0060081)2.80568514
122regulation of ARF protein signal transduction (GO:0032012)2.79329203
123vesicle transport along microtubule (GO:0047496)2.78438271
124neurotransmitter transport (GO:0006836)2.78186732
125striatum development (GO:0021756)2.77856767
126cilium movement (GO:0003341)2.77038582
127somite development (GO:0061053)2.76152738
128cellular biogenic amine biosynthetic process (GO:0042401)2.75621686
129mechanosensory behavior (GO:0007638)2.75572188
130neuronal ion channel clustering (GO:0045161)2.74946395
131regulation of neurotransmitter secretion (GO:0046928)2.74719329
132membrane depolarization during action potential (GO:0086010)2.73286393
133rhodopsin mediated signaling pathway (GO:0016056)2.73256284
134alanine transport (GO:0032328)2.72996743
135cilium organization (GO:0044782)2.72319102
136transmission of nerve impulse (GO:0019226)2.71757464
137regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.71481813
138regulation of dendritic spine development (GO:0060998)2.71249488
139axoneme assembly (GO:0035082)2.71024793
140opioid receptor signaling pathway (GO:0038003)2.70925887
141cell migration in hindbrain (GO:0021535)2.70811384
142dendritic spine organization (GO:0097061)2.70310796
143regulation of glucokinase activity (GO:0033131)2.69393981
144regulation of hexokinase activity (GO:1903299)2.69393981
145axonemal dynein complex assembly (GO:0070286)2.69362395
146membrane depolarization (GO:0051899)2.69168304
147retinal cone cell development (GO:0046549)2.69122275
148presynaptic membrane organization (GO:0097090)2.68835274
149potassium ion homeostasis (GO:0055075)2.68092789
150protein polyglutamylation (GO:0018095)2.67997493
151cilium assembly (GO:0042384)2.67685098
152positive regulation of dendritic spine development (GO:0060999)2.67637952
153regulation of synapse maturation (GO:0090128)2.67119593
154cerebellar Purkinje cell layer development (GO:0021680)2.66969869
155regulation of telomere maintenance (GO:0032204)2.66900894
156cellular sodium ion homeostasis (GO:0006883)2.66874606
157synapse organization (GO:0050808)2.66522147
158phasic smooth muscle contraction (GO:0014821)2.66327405
159ketone body metabolic process (GO:1902224)2.65809480
160positive regulation of action potential (GO:0045760)2.64561585
161central nervous system projection neuron axonogenesis (GO:0021952)2.64505288
162long-term synaptic potentiation (GO:0060291)2.63579697
163regulation of neurotransmitter levels (GO:0001505)2.62492439
164regulation of membrane repolarization (GO:0060306)2.62214835
165cell communication involved in cardiac conduction (GO:0086065)2.60770923
166positive regulation of vesicle fusion (GO:0031340)2.59788417
167regulation of microtubule-based movement (GO:0060632)2.59541828
168presynaptic membrane assembly (GO:0097105)2.59483466
169neuromuscular process (GO:0050905)2.58930271
170regulation of neurotransmitter transport (GO:0051588)2.58880961
171G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.58129902
172amine biosynthetic process (GO:0009309)2.57723959
173renal tubule morphogenesis (GO:0061333)2.55575940
174nucleobase catabolic process (GO:0046113)2.55300599
175respiratory chain complex IV assembly (GO:0008535)2.54742864
176regulation of mesoderm development (GO:2000380)2.54251311
177mannosylation (GO:0097502)2.54223474
178inner ear receptor stereocilium organization (GO:0060122)2.54129357
179cilium morphogenesis (GO:0060271)2.51730819
180protein complex biogenesis (GO:0070271)2.51502960
181atrial cardiac muscle cell action potential (GO:0086014)2.51002539
182pseudouridine synthesis (GO:0001522)2.50425607
183behavioral response to ethanol (GO:0048149)2.47801097
184reflex (GO:0060004)2.45955179
185response to pheromone (GO:0019236)2.45707392
186synaptic transmission, cholinergic (GO:0007271)2.45570778
187piRNA metabolic process (GO:0034587)2.45351922
188tachykinin receptor signaling pathway (GO:0007217)2.44700319
189tryptophan metabolic process (GO:0006568)2.43326160
190cAMP catabolic process (GO:0006198)2.42597619
191C4-dicarboxylate transport (GO:0015740)2.41483613

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.78830853
2VDR_22108803_ChIP-Seq_LS180_Human3.74821359
3GBX2_23144817_ChIP-Seq_PC3_Human3.08520072
4* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.94070587
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.89814952
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.70444788
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.65886508
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.65886508
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.55780157
10DROSHA_22980978_ChIP-Seq_HELA_Human2.53681916
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.48793781
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.48373524
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.46378914
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.43905258
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.40024415
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.36419153
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.33559535
18RARB_27405468_Chip-Seq_BRAIN_Mouse2.29391030
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.23639547
20REST_21632747_ChIP-Seq_MESCs_Mouse2.18268937
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.16308988
22FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.15271427
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.14385629
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.12120808
25SUZ12_27294783_Chip-Seq_ESCs_Mouse2.11168510
26TAF15_26573619_Chip-Seq_HEK293_Human2.10101228
27POU3F2_20337985_ChIP-ChIP_501MEL_Human2.04074954
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.99998323
29FLI1_27457419_Chip-Seq_LIVER_Mouse1.95893196
30EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.95258485
31IGF1R_20145208_ChIP-Seq_DFB_Human1.92043607
32AR_21572438_ChIP-Seq_LNCaP_Human1.89396614
33SALL1_21062744_ChIP-ChIP_HESCs_Human1.87502849
34FUS_26573619_Chip-Seq_HEK293_Human1.87455176
35EWS_26573619_Chip-Seq_HEK293_Human1.83638843
36REST_18959480_ChIP-ChIP_MESCs_Mouse1.79093512
37* MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.73342214
38IKZF1_21737484_ChIP-ChIP_HCT116_Human1.72239869
39PCGF2_27294783_Chip-Seq_ESCs_Mouse1.71692588
40ER_23166858_ChIP-Seq_MCF-7_Human1.70374720
41BMI1_23680149_ChIP-Seq_NPCS_Mouse1.66571708
42CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.61705625
43HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.56013118
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.55054659
45UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.52051688
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.49281070
47SMAD4_21799915_ChIP-Seq_A2780_Human1.46805972
48RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43744462
49ZNF217_24962896_ChIP-Seq_MCF-7_Human1.43158026
50PCGF2_27294783_Chip-Seq_NPCs_Mouse1.42897575
51WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.42355970
52WT1_25993318_ChIP-Seq_PODOCYTE_Human1.42012918
53CTBP2_25329375_ChIP-Seq_LNCAP_Human1.41921509
54ERG_21242973_ChIP-ChIP_JURKAT_Human1.41321153
55RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.40758032
56PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.39762780
57MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.39388811
58RNF2_27304074_Chip-Seq_NSC_Mouse1.37857228
59EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.37519076
60MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.37288329
61NOTCH1_21737748_ChIP-Seq_TLL_Human1.36215929
62RING1B_27294783_Chip-Seq_ESCs_Mouse1.33281749
63SMAD_19615063_ChIP-ChIP_OVARY_Human1.33110014
64SOX2_21211035_ChIP-Seq_LN229_Gbm1.32874331
65CDX2_19796622_ChIP-Seq_MESCs_Mouse1.31733901
66TP53_22573176_ChIP-Seq_HFKS_Human1.31161699
67SUZ12_27294783_Chip-Seq_NPCs_Mouse1.30774187
68ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.29831545
69MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29590813
70AR_19668381_ChIP-Seq_PC3_Human1.29220916
71NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.27615349
72POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.25193213
73TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25193213
74SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25179003
75PIAS1_25552417_ChIP-Seq_VCAP_Human1.24943312
76BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.24143738
77TCF4_22108803_ChIP-Seq_LS180_Human1.23786386
78CBP_20019798_ChIP-Seq_JUKART_Human1.23332551
79IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.23332551
80KDM2B_26808549_Chip-Seq_K562_Human1.22315242
81TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22280726
82TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.21429128
83CTBP1_25329375_ChIP-Seq_LNCAP_Human1.21279827
84NFE2_27457419_Chip-Seq_LIVER_Mouse1.20778667
85EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.20631635
86AHR_22903824_ChIP-Seq_MCF-7_Human1.20329820
87* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.19262706
88NR3C1_23031785_ChIP-Seq_PC12_Mouse1.19171936
89STAT3_23295773_ChIP-Seq_U87_Human1.17894370
90NANOG_18555785_Chip-Seq_ESCs_Mouse1.17878415
91RING1B_27294783_Chip-Seq_NPCs_Mouse1.17661694
92ARNT_22903824_ChIP-Seq_MCF-7_Human1.16144118
93TP53_16413492_ChIP-PET_HCT116_Human1.16070016
94DNAJC2_21179169_ChIP-ChIP_NT2_Human1.14765528
95SMAD3_21741376_ChIP-Seq_EPCs_Human1.14218445
96ZFP281_18757296_ChIP-ChIP_E14_Mouse1.14068278
97TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13419616
98PRDM14_20953172_ChIP-Seq_ESCs_Human1.13274612
99NANOG_19829295_ChIP-Seq_ESCs_Human1.13099752
100SOX2_19829295_ChIP-Seq_ESCs_Human1.13099752
101EP300_21415370_ChIP-Seq_HL-1_Mouse1.12924972
102FOXA1_27270436_Chip-Seq_PROSTATE_Human1.12678165
103FOXA1_25329375_ChIP-Seq_VCAP_Human1.12678165
104POU5F1_16153702_ChIP-ChIP_HESCs_Human1.12534069
105AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12317875
106HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.11905501
107VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.11492949
108YAP1_20516196_ChIP-Seq_MESCs_Mouse1.11357036
109P53_22387025_ChIP-Seq_ESCs_Mouse1.11208406
110AR_25329375_ChIP-Seq_VCAP_Human1.09896056
111CTNNB1_20460455_ChIP-Seq_HCT116_Human1.09877462
112FLI1_21867929_ChIP-Seq_TH2_Mouse1.09231327
113SMAD4_21741376_ChIP-Seq_EPCs_Human1.09202874
114EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.09066471
115GATA3_21878914_ChIP-Seq_MCF-7_Human1.08937142
116P300_19829295_ChIP-Seq_ESCs_Human1.06835860
117OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06032021
118SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05555503
119RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.05120153
120SMAD4_21741376_ChIP-Seq_HESCs_Human1.05049985
121TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.04929642
122MYC_18940864_ChIP-ChIP_HL60_Human1.04613015
123RXR_22108803_ChIP-Seq_LS180_Human1.04554866
124KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03730966
125EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.03548345
126ETV2_25802403_ChIP-Seq_MESCs_Mouse1.03318974
127EZH2_27294783_Chip-Seq_NPCs_Mouse1.02493954
128TCF4_23295773_ChIP-Seq_U87_Human1.02328764
129EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.02312446
130SMAD3_21741376_ChIP-Seq_HESCs_Human1.02173382
131FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02109422
132CBX2_27304074_Chip-Seq_ESCs_Mouse1.01880547
133ZNF274_21170338_ChIP-Seq_K562_Hela1.01345713
134CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00815837
135ZFP57_27257070_Chip-Seq_ESCs_Mouse0.99478645
136P53_22127205_ChIP-Seq_FIBROBLAST_Human0.98914115
137PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.98890052
138TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98810269
139NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98350540
140BCAT_22108803_ChIP-Seq_LS180_Human0.97524945
141TRIM28_21343339_ChIP-Seq_HEK293_Human0.97488432
142DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.97265499
143TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96759750
144SMAD3_21741376_ChIP-Seq_ESCs_Human0.96318420
145TP53_20018659_ChIP-ChIP_R1E_Mouse0.95835862
146MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95235732
147ZFP281_27345836_Chip-Seq_ESCs_Mouse0.94789474
148CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.94756313
149TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.94082761
150BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.93997425
151TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.92345852
152ISL1_27105846_Chip-Seq_CPCs_Mouse0.90870050
153OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.90546077
154RUNX2_22187159_ChIP-Seq_PCA_Human0.86943320

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.97230453
2MP0003635_abnormal_synaptic_transmissio3.74085459
3MP0004270_analgesia3.42137576
4MP0003880_abnormal_central_pattern3.19621495
5MP0002822_catalepsy2.96411243
6MP0002063_abnormal_learning/memory/cond2.93381178
7MP0009780_abnormal_chondrocyte_physiolo2.92857233
8MP0009745_abnormal_behavioral_response2.88050572
9MP0005423_abnormal_somatic_nervous2.83584392
10MP0003195_calcinosis2.65073344
11MP0009046_muscle_twitch2.64666734
12MP0002064_seizures2.62495207
13MP0002572_abnormal_emotion/affect_behav2.36617454
14MP0002734_abnormal_mechanical_nocicepti2.32526892
15MP0008877_abnormal_DNA_methylation2.30320561
16MP0001968_abnormal_touch/_nociception2.29717350
17MP0001486_abnormal_startle_reflex2.28082499
18MP0002909_abnormal_adrenal_gland2.14055894
19MP0002272_abnormal_nervous_system2.10251204
20MP0006292_abnormal_olfactory_placode2.03742223
21MP0000778_abnormal_nervous_system2.01206526
22MP0004858_abnormal_nervous_system1.97220793
23MP0002102_abnormal_ear_morphology1.96113033
24MP0003283_abnormal_digestive_organ1.95990823
25MP0003646_muscle_fatigue1.93649668
26MP0002876_abnormal_thyroid_physiology1.93004640
27MP0004885_abnormal_endolymph1.88874579
28MP0006072_abnormal_retinal_apoptosis1.87508874
29MP0008569_lethality_at_weaning1.87172723
30MP0008872_abnormal_physiological_respon1.84476079
31MP0005646_abnormal_pituitary_gland1.80134110
32MP0002735_abnormal_chemical_nociception1.75379594
33MP0004811_abnormal_neuron_physiology1.72250511
34MP0002733_abnormal_thermal_nociception1.69266462
35MP0000013_abnormal_adipose_tissue1.68130651
36MP0002736_abnormal_nociception_after1.65527838
37MP0000955_abnormal_spinal_cord1.63477518
38MP0004133_heterotaxia1.61732202
39MP0001986_abnormal_taste_sensitivity1.60266042
40MP0002184_abnormal_innervation1.59748332
41MP0002557_abnormal_social/conspecific_i1.58997763
42MP0001970_abnormal_pain_threshold1.58630483
43MP0001440_abnormal_grooming_behavior1.56656667
44MP0005253_abnormal_eye_physiology1.54263927
45MP0002067_abnormal_sensory_capabilities1.54093580
46MP0003879_abnormal_hair_cell1.53732151
47MP0001501_abnormal_sleep_pattern1.53021952
48MP0004742_abnormal_vestibular_system1.45984120
49MP0000751_myopathy1.45042944
50MP0003011_delayed_dark_adaptation1.44816911
51MP0008875_abnormal_xenobiotic_pharmacok1.42818663
52MP0000569_abnormal_digit_pigmentation1.41241276
53MP0005386_behavior/neurological_phenoty1.38167851
54MP0004924_abnormal_behavior1.38167851
55MP0002638_abnormal_pupillary_reflex1.37603355
56MP0003329_amyloid_beta_deposits1.37411563
57MP0005645_abnormal_hypothalamus_physiol1.35906017
58MP0002882_abnormal_neuron_morphology1.35839423
59MP0003633_abnormal_nervous_system1.35830146
60MP0004147_increased_porphyrin_level1.34481889
61MP0001905_abnormal_dopamine_level1.33866835
62MP0001984_abnormal_olfaction1.32990871
63MP0003136_yellow_coat_color1.31584186
64MP0005075_abnormal_melanosome_morpholog1.30847580
65MP0000427_abnormal_hair_cycle1.29162934
66MP0004233_abnormal_muscle_weight1.28946391
67MP0002938_white_spotting1.28741854
68MP0003121_genomic_imprinting1.26992544
69MP0001299_abnormal_eye_distance/1.25020331
70MP0003122_maternal_imprinting1.22090749
71MP0002066_abnormal_motor_capabilities/c1.21758735
72MP0003690_abnormal_glial_cell1.16485133
73MP0001485_abnormal_pinna_reflex1.16431780
74MP0002751_abnormal_autonomic_nervous1.15225365
75MP0005379_endocrine/exocrine_gland_phen1.15163952
76MP0001177_atelectasis1.14785940
77MP0001502_abnormal_circadian_rhythm1.14441239
78MP0002163_abnormal_gland_morphology1.14062857
79MP0002152_abnormal_brain_morphology1.11828106
80MP0000372_irregular_coat_pigmentation1.09171462
81MP0005195_abnormal_posterior_eye1.07763189
82MP0003631_nervous_system_phenotype1.07742143
83MP0004145_abnormal_muscle_electrophysio1.06470653
84MP0000647_abnormal_sebaceous_gland1.04898780
85MP0001348_abnormal_lacrimal_gland1.03702250
86MP0008961_abnormal_basal_metabolism1.03303397
87MP0005623_abnormal_meninges_morphology1.03215057
88MP0004215_abnormal_myocardial_fiber1.02765726
89MP0002653_abnormal_ependyma_morphology1.01453095
90MP0004085_abnormal_heartbeat1.00390385
91MP0005389_reproductive_system_phenotype1.00248705
92MP0003634_abnormal_glial_cell0.98473500
93MP0003787_abnormal_imprinting0.98175156
94MP0003937_abnormal_limbs/digits/tail_de0.97492014
95MP0003890_abnormal_embryonic-extraembry0.97216206
96MP0004130_abnormal_muscle_cell0.96439278
97MP0002160_abnormal_reproductive_system0.95973366
98MP0003137_abnormal_impulse_conducting0.93890489
99MP0004381_abnormal_hair_follicle0.93212469
100MP0002234_abnormal_pharynx_morphology0.91622998
101MP0005377_hearing/vestibular/ear_phenot0.90101726
102MP0003878_abnormal_ear_physiology0.90101726
103MP0000003_abnormal_adipose_tissue0.89816338
104MP0000026_abnormal_inner_ear0.88817160
105MP0001188_hyperpigmentation0.88496826
106MP0003045_fibrosis0.88381268
107MP0005409_darkened_coat_color0.87541934
108MP0002837_dystrophic_cardiac_calcinosis0.87075273
109MP0000230_abnormal_systemic_arterial0.86867284
110MP0005084_abnormal_gallbladder_morpholo0.85537823
111MP0002069_abnormal_eating/drinking_beha0.84837474
112MP0000631_abnormal_neuroendocrine_gland0.83652905
113MP0000049_abnormal_middle_ear0.83599522
114MP0002928_abnormal_bile_duct0.83223659
115MP0002095_abnormal_skin_pigmentation0.82897162
116MP0003075_altered_response_to0.80753471
117MP0005167_abnormal_blood-brain_barrier0.80626534
118MP0003942_abnormal_urinary_system0.78408387
119MP0000534_abnormal_ureter_morphology0.78140328
120MP0005187_abnormal_penis_morphology0.78079269
121MP0005499_abnormal_olfactory_system0.77742721
122MP0005394_taste/olfaction_phenotype0.77742721
123MP0001324_abnormal_eye_pigmentation0.77644854
124MP0003938_abnormal_ear_development0.75712989
125MP0010386_abnormal_urinary_bladder0.75450921
126MP0003632_abnormal_nervous_system0.73623498
127MP0001919_abnormal_reproductive_system0.72501963
128MP0002090_abnormal_vision0.72348549
129MP0002896_abnormal_bone_mineralization0.68423272
130MP0005551_abnormal_eye_electrophysiolog0.68321432
131MP0000920_abnormal_myelination0.68125228
132MP0002229_neurodegeneration0.67081799
133MP0001529_abnormal_vocalization0.66585096
134MP0003861_abnormal_nervous_system0.66428984
135MP0002108_abnormal_muscle_morphology0.66365400
136MP0004043_abnormal_pH_regulation0.66004276
137MP0001943_abnormal_respiration0.65819430
138MP0004142_abnormal_muscle_tone0.65469225
139MP0002752_abnormal_somatic_nervous0.64966794
140MP0005620_abnormal_muscle_contractility0.63816043
141MP0003183_abnormal_peptide_metabolism0.62880676
142MP0006276_abnormal_autonomic_nervous0.62358047
143MP0005503_abnormal_tendon_morphology0.61580142
144MP0008874_decreased_physiological_sensi0.59960126
145MP0005535_abnormal_body_temperature0.59513698
146MP0002089_abnormal_postnatal_growth/wei0.58015162
147MP0003172_abnormal_lysosome_physiology0.56741035

Predicted human phenotypes

RankGene SetZ-score
1Hypothermia (HP:0002045)6.15711822
2Myokymia (HP:0002411)5.37683668
3Focal motor seizures (HP:0011153)5.16109916
4Type II lissencephaly (HP:0007260)4.72453684
5Medial flaring of the eyebrow (HP:0010747)4.38385788
6Focal seizures (HP:0007359)4.37804249
7Limb hypertonia (HP:0002509)4.27787465
8Molar tooth sign on MRI (HP:0002419)4.22573293
9Abnormality of midbrain morphology (HP:0002418)4.22573293
10Abnormal pupillary function (HP:0007686)4.09782885
11Pancreatic cysts (HP:0001737)4.06047616
12Action tremor (HP:0002345)3.91685581
13Progressive cerebellar ataxia (HP:0002073)3.75239412
14Congenital stationary night blindness (HP:0007642)3.67100132
15Epileptic encephalopathy (HP:0200134)3.64608947
16Pancreatic fibrosis (HP:0100732)3.50015695
17Retinal dysplasia (HP:0007973)3.48768431
18Visual hallucinations (HP:0002367)3.43069579
19True hermaphroditism (HP:0010459)3.28567919
20Nephronophthisis (HP:0000090)3.16697226
21Megalencephaly (HP:0001355)3.14309873
22Cerebellar dysplasia (HP:0007033)3.14144548
23Ankle clonus (HP:0011448)3.08642447
24Supranuclear gaze palsy (HP:0000605)3.04778809
25Genetic anticipation (HP:0003743)3.02128614
26Febrile seizures (HP:0002373)3.01370334
27Chronic hepatic failure (HP:0100626)2.98468786
28Lissencephaly (HP:0001339)2.96202803
29Atonic seizures (HP:0010819)2.90568277
30Broad-based gait (HP:0002136)2.89948758
31Poor eye contact (HP:0000817)2.89907043
32Aplasia involving bones of the upper limbs (HP:0009823)2.86566049
33Aplasia of the phalanges of the hand (HP:0009802)2.86566049
34Aplasia involving bones of the extremities (HP:0009825)2.86566049
35Abnormality of the renal medulla (HP:0100957)2.76353260
36Depression (HP:0000716)2.76133401
37Hemiparesis (HP:0001269)2.74999398
38Dysdiadochokinesis (HP:0002075)2.71991152
39Absence seizures (HP:0002121)2.69951061
40Generalized tonic-clonic seizures (HP:0002069)2.68214045
41Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.68062647
42Impaired social interactions (HP:0000735)2.67617293
43Abnormal social behavior (HP:0012433)2.67617293
44Truncal ataxia (HP:0002078)2.66256739
45Papilledema (HP:0001085)2.66190554
46Gait imbalance (HP:0002141)2.65568519
47Abnormality of the renal cortex (HP:0011035)2.63914501
48Abnormal respiratory motile cilium morphology (HP:0005938)2.63107303
49Abnormal respiratory epithelium morphology (HP:0012253)2.63107303
50Postural instability (HP:0002172)2.62832084
51Urinary bladder sphincter dysfunction (HP:0002839)2.62737746
52Ankyloglossia (HP:0010296)2.62118843
53Hemiplegia (HP:0002301)2.60391345
54Torticollis (HP:0000473)2.60014985
55Impaired vibration sensation in the lower limbs (HP:0002166)2.59094357
56Protruding tongue (HP:0010808)2.58959465
57Abolished electroretinogram (ERG) (HP:0000550)2.55539194
58Inability to walk (HP:0002540)2.54855447
59Decreased central vision (HP:0007663)2.54670324
60Dialeptic seizures (HP:0011146)2.53087191
61Prolonged QT interval (HP:0001657)2.52608653
62Gaze-evoked nystagmus (HP:0000640)2.52543876
63Large for gestational age (HP:0001520)2.52493942
64Dysmetric saccades (HP:0000641)2.47276048
653-Methylglutaconic aciduria (HP:0003535)2.45386018
66Anxiety (HP:0000739)2.42573989
67Pendular nystagmus (HP:0012043)2.42514719
68Congenital primary aphakia (HP:0007707)2.41365199
69Anterior segment dysgenesis (HP:0007700)2.40108060
70Dysmetria (HP:0001310)2.39987943
71Excessive salivation (HP:0003781)2.37571575
72Drooling (HP:0002307)2.37571575
73Scanning speech (HP:0002168)2.37215611
74Bony spicule pigmentary retinopathy (HP:0007737)2.36478058
75Increased hepatocellular lipid droplets (HP:0006565)2.34475313
76Chorioretinal atrophy (HP:0000533)2.34133192
77Abnormal eating behavior (HP:0100738)2.32688685
78Abnormality of alanine metabolism (HP:0010916)2.32310118
79Hyperalaninemia (HP:0003348)2.32310118
80Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.32310118
81Concave nail (HP:0001598)2.31387753
82Pachygyria (HP:0001302)2.30740112
83Macroorchidism (HP:0000053)2.29931611
84Impaired smooth pursuit (HP:0007772)2.29804254
85Hyperventilation (HP:0002883)2.29405909
86Focal dystonia (HP:0004373)2.27942316
87Genital tract atresia (HP:0001827)2.27804734
88Bronchomalacia (HP:0002780)2.25541816
89Severe muscular hypotonia (HP:0006829)2.25365970
90Abnormal number of erythroid precursors (HP:0012131)2.25108345
91Cystic liver disease (HP:0006706)2.23591461
92Lipid accumulation in hepatocytes (HP:0006561)2.21981882
93Aplasia/Hypoplasia of the tibia (HP:0005772)2.21242452
94Progressive inability to walk (HP:0002505)2.20716101
95Bundle branch block (HP:0011710)2.18935372
96Intention tremor (HP:0002080)2.18536633
97Nephrogenic diabetes insipidus (HP:0009806)2.18437958
98Lower limb muscle weakness (HP:0007340)2.16547911
99Abnormal EKG (HP:0003115)2.15579935
100Mutism (HP:0002300)2.15066513
101Vaginal atresia (HP:0000148)2.15049415
102Keratoconus (HP:0000563)2.14931475
103Increased corneal curvature (HP:0100692)2.14931475
104Stereotypic behavior (HP:0000733)2.14760699
105Abnormal ciliary motility (HP:0012262)2.13820073
106Spastic gait (HP:0002064)2.12397036
107Neurofibrillary tangles (HP:0002185)2.12112854
108Attenuation of retinal blood vessels (HP:0007843)2.11704170
109Shallow orbits (HP:0000586)2.09890846
110Congenital, generalized hypertrichosis (HP:0004540)2.09817037
111Pointed chin (HP:0000307)2.09401037
112Mitochondrial inheritance (HP:0001427)2.08870286
113Polydipsia (HP:0001959)2.08840393
114Abnormal drinking behavior (HP:0030082)2.08840393
115Tubular atrophy (HP:0000092)2.08325083
116Lower limb amyotrophy (HP:0007210)2.06845051
117Dynein arm defect of respiratory motile cilia (HP:0012255)2.05937157
118Absent/shortened dynein arms (HP:0200106)2.05937157
119Ventricular fibrillation (HP:0001663)2.05027790
120Abnormal rod and cone electroretinograms (HP:0008323)2.04796070
121Hypoventilation (HP:0002791)2.03305113
122Abnormality of the lower motor neuron (HP:0002366)2.02588846
123Diplopia (HP:0000651)2.02468604
124Abnormality of binocular vision (HP:0011514)2.02468604
125Renal cortical cysts (HP:0000803)2.01775835
126Progressive macrocephaly (HP:0004481)2.00638614
127Annular pancreas (HP:0001734)2.00597836
128Postaxial hand polydactyly (HP:0001162)1.99018642
129Sclerocornea (HP:0000647)1.98236404
130Craniofacial dystonia (HP:0012179)1.98177440
131Obstructive sleep apnea (HP:0002870)1.97600818
132Agitation (HP:0000713)1.97040599
133Neoplasm of the heart (HP:0100544)1.96451362
134Abnormality of ocular smooth pursuit (HP:0000617)1.96257038
135Aplasia/Hypoplasia of the tongue (HP:0010295)1.95908095
136EEG with generalized epileptiform discharges (HP:0011198)1.95463856
137Increased CSF lactate (HP:0002490)1.95165111
138Epileptiform EEG discharges (HP:0011182)1.94920497
139Furrowed tongue (HP:0000221)1.93942555
140Patellar aplasia (HP:0006443)1.93865521
141Abnormality of the pons (HP:0007361)1.91953816
142Cerebral inclusion bodies (HP:0100314)1.90800216
143Hypsarrhythmia (HP:0002521)1.90587981
144Aplasia/Hypoplasia of the patella (HP:0006498)1.90567375
145Optic nerve hypoplasia (HP:0000609)1.89873810
146Insomnia (HP:0100785)1.89578278
147Urinary urgency (HP:0000012)1.89500979
148Overgrowth (HP:0001548)1.87847494
149Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.87712747
150Prominent nasal bridge (HP:0000426)1.86481846
151Narrow nasal bridge (HP:0000446)1.85548560
152Acute necrotizing encephalopathy (HP:0006965)1.85535438
153Abnormality of oral frenula (HP:0000190)1.85434084
154Renal Fanconi syndrome (HP:0001994)1.84641493
155Aqueductal stenosis (HP:0002410)1.84348811
156Hypoplasia of the pons (HP:0012110)1.84339566
157Exertional dyspnea (HP:0002875)1.84299495
158Bilateral microphthalmos (HP:0007633)1.81123260
159Stomach cancer (HP:0012126)1.80799208
160Broad metatarsal (HP:0001783)1.79601548
161Decreased electroretinogram (ERG) amplitude (HP:0000654)1.79361948
162Narrow forehead (HP:0000341)1.78371064
163Bradykinesia (HP:0002067)1.77774282
164Birth length less than 3rd percentile (HP:0003561)1.76873699
165Short tibia (HP:0005736)1.76774703
166Congenital hepatic fibrosis (HP:0002612)1.76571518
167Atrial fibrillation (HP:0005110)1.76442478
168Resting tremor (HP:0002322)1.76341332
169Amblyopia (HP:0000646)1.76211829
170Termporal pattern (HP:0011008)1.75514095
171Insidious onset (HP:0003587)1.75514095
172Poor coordination (HP:0002370)1.73739979
173Limb dystonia (HP:0002451)1.72968801
174Decreased circulating renin level (HP:0003351)1.72624805
175Spinal canal stenosis (HP:0003416)1.72581602
176Turricephaly (HP:0000262)1.72475807
177Clonus (HP:0002169)1.72160099
178Primary atrial arrhythmia (HP:0001692)1.71893349
179Anencephaly (HP:0002323)1.71518815
180Male pseudohermaphroditism (HP:0000037)1.70029109
181Impaired vibratory sensation (HP:0002495)1.69567786
182Cutaneous finger syndactyly (HP:0010554)1.68721627
183Aplasia/hypoplasia of the uterus (HP:0008684)1.68239892
184Absent speech (HP:0001344)1.64781991
185Incomplete penetrance (HP:0003829)1.59131397
186Bradycardia (HP:0001662)1.56641678
187Blue irides (HP:0000635)1.55929003
188Supraventricular tachycardia (HP:0004755)1.55404340

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.82530968
2EPHA44.17686818
3ADRBK23.74076682
4NTRK33.65554705
5MARK13.37427430
6MAP3K93.22266753
7PRKD33.21767707
8GRK12.68544171
9BMPR1B2.59165571
10TLK12.37234515
11ACVR1B2.34262008
12DAPK22.30631514
13ZAK2.29035905
14MINK12.23053111
15MAP4K22.18175927
16OXSR12.16165370
17PAK62.13582174
18NTRK22.06704312
19NUAK12.05079952
20CAMKK12.02693723
21MAP3K42.02426216
22NTRK11.87135711
23KSR21.83517848
24TAOK31.79977534
25PHKG21.74844235
26PHKG11.74844235
27STK391.58461486
28ICK1.54032548
29KSR11.51463986
30PNCK1.47591887
31MKNK21.47273775
32TNIK1.45313256
33CAMKK21.45097834
34TXK1.43837432
35CDK51.42258304
36LMTK21.40400281
37TYRO31.34512505
38MAP2K71.32864856
39CASK1.32441376
40TAOK21.31282633
41MAPK131.31226530
42TAOK11.27421709
43STK381.25943219
44PRKCH1.21787334
45DYRK21.21234562
46ADRBK11.19990064
47ARAF1.17434547
48SGK2231.16574732
49SGK4941.16574732
50TIE11.15923813
51PDGFRA1.14299623
52TRIB31.13198320
53UHMK11.11810146
54DDR21.11700565
55PRPF4B1.11423254
56RIPK11.11383790
57MAP3K21.11229759
58SGK21.10888776
59LATS21.08170790
60MAP3K131.07046481
61SGK31.06569342
62DAPK11.04057856
63MARK21.04035586
64MAP2K41.03073567
65PAK31.02861408
66RET1.02796674
67SIK21.02405486
68PRKCG0.99092997
69WNK10.93608798
70TGFBR10.91925871
71FGFR20.90561578
72CDC42BPA0.85672785
73CDK190.84194526
74PLK20.82933346
75DMPK0.81472591
76MAPK150.80687335
77MUSK0.79243880
78RIPK40.77465697
79SGK10.76281824
80MAPKAPK30.76015502
81STK110.75831376
82CAMK10.75480513
83CAMK2A0.73604357
84PKN10.73074927
85CDK150.72423148
86CDK180.72136302
87STK38L0.72094885
88CAMK1G0.69144226
89ALK0.68797693
90CDK140.68771333
91ERBB20.67969547
92PDPK10.67284475
93INSRR0.66665421
94BCR0.65250068
95MAP2K20.63518030
96PDK10.62269134
97CDK11A0.60362723
98MAPKAPK50.60064957
99SIK10.60025947
100DYRK1A0.59750579
101LIMK10.59643691
102VRK10.59306552
103PRKD20.58883940
104FES0.58201902
105BRD40.57948674
106MAP3K10.56853264
107GRK50.56206008
108ROCK10.56174008
109RPS6KA30.55926353
110CAMK40.55226004
111PRKACA0.54403093
112WNK30.54388001
113PRKCE0.54167544
114PINK10.53524496
115RAF10.51920745
116RPS6KA50.51377844
117PRKD10.51372655
118FGFR10.51267647
119CSNK1G30.49961597
120PRKCZ0.49743733
121NEK60.49577670
122EPHB20.49573974
123CAMK2B0.49483570
124NEK20.49461879
125CSNK1G10.49240866
126CSNK1A10.49038464
127CHUK0.48975311
128PTK2B0.48960760
129OBSCN0.48934155
130MKNK10.47998029
131IKBKB0.47689915
132TEC0.47516422
133FYN0.47376376
134MAP2K60.44728632
135MAPK100.44263142
136PIK3CA0.44002421
137TRIM280.43671683
138WNK40.43438191
139FER0.43146958
140TAF10.43023284
141PLK40.41819952
142NME10.40861097
143FGFR30.40700943
144MAP3K70.39605309
145MYLK0.39417744
146AKT30.39275447
147SCYL20.38857570
148CAMK2D0.37973801
149PTK20.37665320
150CSNK1G20.37654493
151PRKAA10.37526553
152BCKDK0.37445223
153PRKG10.37414095
154BRSK20.35921521
155CSNK1A1L0.35463614
156PRKCA0.34314937
157ITK0.34240431
158CSNK1D0.33994211
159STK30.33040829
160PRKACB0.32290547
161KIT0.30242348
162PRKCQ0.29150969

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.73558685
2Circadian entrainment_Homo sapiens_hsa047132.48385960
3Olfactory transduction_Homo sapiens_hsa047402.44538244
4Tryptophan metabolism_Homo sapiens_hsa003802.44396724
5Oxidative phosphorylation_Homo sapiens_hsa001902.39664166
6Synaptic vesicle cycle_Homo sapiens_hsa047212.37910656
7GABAergic synapse_Homo sapiens_hsa047272.33752445
8Histidine metabolism_Homo sapiens_hsa003402.32303990
9Glutamatergic synapse_Homo sapiens_hsa047242.28918286
10Long-term potentiation_Homo sapiens_hsa047202.25510428
11Linoleic acid metabolism_Homo sapiens_hsa005912.21247799
12Morphine addiction_Homo sapiens_hsa050322.20633970
13Insulin secretion_Homo sapiens_hsa049112.14762394
14Amphetamine addiction_Homo sapiens_hsa050312.12232789
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.11656264
16Phenylalanine metabolism_Homo sapiens_hsa003602.05619487
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.96257689
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.93514655
19Selenocompound metabolism_Homo sapiens_hsa004501.91686161
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.89510092
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.89038103
22Salivary secretion_Homo sapiens_hsa049701.88035880
23Dopaminergic synapse_Homo sapiens_hsa047281.86700661
24Parkinsons disease_Homo sapiens_hsa050121.86225763
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.81769005
26Nitrogen metabolism_Homo sapiens_hsa009101.81632869
27Cholinergic synapse_Homo sapiens_hsa047251.80692972
28Butanoate metabolism_Homo sapiens_hsa006501.76072134
29Cocaine addiction_Homo sapiens_hsa050301.75906443
30Gastric acid secretion_Homo sapiens_hsa049711.74492135
31Caffeine metabolism_Homo sapiens_hsa002321.72005908
32Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.68768974
33Maturity onset diabetes of the young_Homo sapiens_hsa049501.68123326
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.65079145
35Renin secretion_Homo sapiens_hsa049241.58831320
36Oxytocin signaling pathway_Homo sapiens_hsa049211.51880778
37Ether lipid metabolism_Homo sapiens_hsa005651.51820517
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.44022913
39Calcium signaling pathway_Homo sapiens_hsa040201.43019769
40Type II diabetes mellitus_Homo sapiens_hsa049301.42667784
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.41000473
42Gap junction_Homo sapiens_hsa045401.38925327
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.38437282
44Long-term depression_Homo sapiens_hsa047301.37702023
45Taste transduction_Homo sapiens_hsa047421.37470893
46GnRH signaling pathway_Homo sapiens_hsa049121.36126465
47Protein export_Homo sapiens_hsa030601.35455995
48Tyrosine metabolism_Homo sapiens_hsa003501.33792089
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.32463696
50cAMP signaling pathway_Homo sapiens_hsa040241.30455946
51RNA polymerase_Homo sapiens_hsa030201.30436249
52Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.28688752
53Axon guidance_Homo sapiens_hsa043601.28312089
54Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.28198566
55Glioma_Homo sapiens_hsa052141.23288845
56Basal transcription factors_Homo sapiens_hsa030221.22657012
57ABC transporters_Homo sapiens_hsa020101.21984255
58Serotonergic synapse_Homo sapiens_hsa047261.21357080
59Alzheimers disease_Homo sapiens_hsa050101.21201914
60Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.20357187
61Estrogen signaling pathway_Homo sapiens_hsa049151.18251384
62Dorso-ventral axis formation_Homo sapiens_hsa043201.17708798
63Melanogenesis_Homo sapiens_hsa049161.16516699
64Dilated cardiomyopathy_Homo sapiens_hsa054141.15591571
65Huntingtons disease_Homo sapiens_hsa050161.12951383
66cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09363690
67Primary bile acid biosynthesis_Homo sapiens_hsa001201.07044922
68Phosphatidylinositol signaling system_Homo sapiens_hsa040701.04940958
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.04347192
70Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.00580567
71ErbB signaling pathway_Homo sapiens_hsa040120.99602063
72Chemical carcinogenesis_Homo sapiens_hsa052040.98759965
73Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.96048714
74Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.95220443
75Phospholipase D signaling pathway_Homo sapiens_hsa040720.94951199
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.90726504
77Peroxisome_Homo sapiens_hsa041460.90683004
78Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.90186205
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.89858775
80Thyroid hormone signaling pathway_Homo sapiens_hsa049190.87936765
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.87380357
82Thyroid hormone synthesis_Homo sapiens_hsa049180.86796112
83Pancreatic secretion_Homo sapiens_hsa049720.85759398
84Retinol metabolism_Homo sapiens_hsa008300.84899979
85mTOR signaling pathway_Homo sapiens_hsa041500.83707807
86Glucagon signaling pathway_Homo sapiens_hsa049220.82564093
87Homologous recombination_Homo sapiens_hsa034400.79284278
88Endometrial cancer_Homo sapiens_hsa052130.78714585
89Fatty acid biosynthesis_Homo sapiens_hsa000610.78237159
90Rap1 signaling pathway_Homo sapiens_hsa040150.77959066
91Circadian rhythm_Homo sapiens_hsa047100.77768880
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.76450870
93RNA degradation_Homo sapiens_hsa030180.76066375
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.75824323
95Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.75057066
96MAPK signaling pathway_Homo sapiens_hsa040100.74812904
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.74399358
98Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.73266295
99Neurotrophin signaling pathway_Homo sapiens_hsa047220.71636527
100Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.71557780
101Insulin signaling pathway_Homo sapiens_hsa049100.69371727
102Propanoate metabolism_Homo sapiens_hsa006400.69361629
103Choline metabolism in cancer_Homo sapiens_hsa052310.68858460
104Oocyte meiosis_Homo sapiens_hsa041140.66726448
105Bile secretion_Homo sapiens_hsa049760.63919811
106Wnt signaling pathway_Homo sapiens_hsa043100.63450483
107beta-Alanine metabolism_Homo sapiens_hsa004100.63370485
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62282890
109Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61755158
110Fanconi anemia pathway_Homo sapiens_hsa034600.61576371
111Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.61395283
112Cardiac muscle contraction_Homo sapiens_hsa042600.60661267
113Non-small cell lung cancer_Homo sapiens_hsa052230.60271146
114Ras signaling pathway_Homo sapiens_hsa040140.59073550
115Prion diseases_Homo sapiens_hsa050200.57518481
116Arachidonic acid metabolism_Homo sapiens_hsa005900.57281120
117Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57174697
118VEGF signaling pathway_Homo sapiens_hsa043700.57082120
119Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54915764
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.54035370
121Endocytosis_Homo sapiens_hsa041440.52302233
122Renal cell carcinoma_Homo sapiens_hsa052110.51684555
123Focal adhesion_Homo sapiens_hsa045100.51140426
124Inositol phosphate metabolism_Homo sapiens_hsa005620.50030973
125Purine metabolism_Homo sapiens_hsa002300.49835811
126Phototransduction_Homo sapiens_hsa047440.48849281
127Vibrio cholerae infection_Homo sapiens_hsa051100.48583429
128Proteoglycans in cancer_Homo sapiens_hsa052050.48528942
129Metabolic pathways_Homo sapiens_hsa011000.48037532
130Hedgehog signaling pathway_Homo sapiens_hsa043400.47713239
131Collecting duct acid secretion_Homo sapiens_hsa049660.46097572
132Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45587569
133Basal cell carcinoma_Homo sapiens_hsa052170.45535386
134Intestinal immune network for IgA production_Homo sapiens_hsa046720.45257317
135Sulfur metabolism_Homo sapiens_hsa009200.44775259
136Glycerolipid metabolism_Homo sapiens_hsa005610.44727413
137Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.44077128
138Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43793595
139Hippo signaling pathway_Homo sapiens_hsa043900.43789665
140Alcoholism_Homo sapiens_hsa050340.43731943
141Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43144093
142Type I diabetes mellitus_Homo sapiens_hsa049400.43061310
143Regulation of autophagy_Homo sapiens_hsa041400.42811484
144Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42616846
145Adipocytokine signaling pathway_Homo sapiens_hsa049200.41900852
146Ovarian steroidogenesis_Homo sapiens_hsa049130.41082257
147Fat digestion and absorption_Homo sapiens_hsa049750.41017254
148One carbon pool by folate_Homo sapiens_hsa006700.40571976
149Insulin resistance_Homo sapiens_hsa049310.40426375
150Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39570571
151Tight junction_Homo sapiens_hsa045300.39316549
152AMPK signaling pathway_Homo sapiens_hsa041520.38720966
153Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38522378
154Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.38405696
155Fatty acid elongation_Homo sapiens_hsa000620.36099968
156Steroid biosynthesis_Homo sapiens_hsa001000.32765339
157SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28142490
158Mineral absorption_Homo sapiens_hsa049780.27701295

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