PCDHGA4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.49803348
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.48157825
3response to pheromone (GO:0019236)5.34649662
4locomotory exploration behavior (GO:0035641)5.20098739
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.16924692
6regulation of synapse structural plasticity (GO:0051823)4.91243589
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.84011518
8vocalization behavior (GO:0071625)4.78966185
9layer formation in cerebral cortex (GO:0021819)4.70877152
10protein heterotrimerization (GO:0070208)4.58162717
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.56048250
12regulation of synaptic vesicle exocytosis (GO:2000300)4.52499318
13synaptic vesicle exocytosis (GO:0016079)4.52157102
14type B pancreatic cell proliferation (GO:0044342)4.44191230
15protein localization to synapse (GO:0035418)4.42417318
16skin morphogenesis (GO:0043589)4.41209586
17collagen fibril organization (GO:0030199)4.37493511
18regulation of glutamate receptor signaling pathway (GO:1900449)4.31462485
19endodermal cell differentiation (GO:0035987)4.31028492
20neuron cell-cell adhesion (GO:0007158)4.30466079
21cell adhesion mediated by integrin (GO:0033627)4.28499040
22glutamate secretion (GO:0014047)4.26672961
23pyrimidine nucleobase catabolic process (GO:0006208)4.13425122
24exploration behavior (GO:0035640)4.06047480
25extracellular matrix assembly (GO:0085029)4.05545550
26synaptic vesicle docking involved in exocytosis (GO:0016081)4.05329545
27sodium ion export (GO:0071436)4.05213053
28sequestering of extracellular ligand from receptor (GO:0035581)4.04649344
29dendrite morphogenesis (GO:0048813)4.02861532
30chondrocyte proliferation (GO:0035988)4.01360939
31positive regulation of synapse maturation (GO:0090129)3.95741825
32cell communication by electrical coupling (GO:0010644)3.91913852
33regulation of synaptic vesicle transport (GO:1902803)3.85846997
34cellular potassium ion homeostasis (GO:0030007)3.85307570
35neurotransmitter secretion (GO:0007269)3.84815920
36dendritic spine morphogenesis (GO:0060997)3.83960293
37cell migration in hindbrain (GO:0021535)3.82055196
38neurotransmitter-gated ion channel clustering (GO:0072578)3.77172868
39axonal fasciculation (GO:0007413)3.75470268
40membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.72670484
41regulation of neuronal synaptic plasticity (GO:0048168)3.71405898
42blood vessel maturation (GO:0001955)3.68015194
43neuron recognition (GO:0008038)3.66419319
44kidney mesenchyme development (GO:0072074)3.63908028
45cell migration involved in heart development (GO:0060973)3.58004337
46regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.57447765
47ionotropic glutamate receptor signaling pathway (GO:0035235)3.56195019
48cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.55325872
49establishment of nucleus localization (GO:0040023)3.55273879
50cerebellar Purkinje cell differentiation (GO:0021702)3.51665391
51cerebellar Purkinje cell layer development (GO:0021680)3.50281234
52cell-substrate junction assembly (GO:0007044)3.48627015
53regulation of long-term neuronal synaptic plasticity (GO:0048169)3.48170026
54bone trabecula formation (GO:0060346)3.47536445
55regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.45900331
56positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.44342615
57substrate-dependent cell migration (GO:0006929)3.40763240
58mesenchymal-epithelial cell signaling (GO:0060638)3.40701870
59metanephric mesenchyme development (GO:0072075)3.39222203
60regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.38191077
61gamma-aminobutyric acid transport (GO:0015812)3.37994406
62cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.36409035
63prepulse inhibition (GO:0060134)3.35907288
64negative regulation of cytosolic calcium ion concentration (GO:0051481)3.34900171
65synaptic transmission, glutamatergic (GO:0035249)3.33139378
66response to auditory stimulus (GO:0010996)3.32951183
67synaptic vesicle endocytosis (GO:0048488)3.32327782
68positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.30803500
69glutamate receptor signaling pathway (GO:0007215)3.30707741
70proline transport (GO:0015824)3.27155486
71nucleobase catabolic process (GO:0046113)3.25199161
72pericardium development (GO:0060039)3.22162284
73vascular endothelial growth factor signaling pathway (GO:0038084)3.21694398
74central nervous system projection neuron axonogenesis (GO:0021952)3.21362742
75neuromuscular process controlling balance (GO:0050885)3.21129973
76long-term memory (GO:0007616)3.19711091
77endocardial cushion development (GO:0003197)3.19136405
78negative regulation of smooth muscle cell migration (GO:0014912)3.18403218
79extracellular fibril organization (GO:0043206)3.17826231
80positive regulation of membrane potential (GO:0045838)3.17604038
81innervation (GO:0060384)3.16856104
82negative regulation of microtubule polymerization (GO:0031115)3.16594764
83activation of protein kinase A activity (GO:0034199)3.16286467
84neuron-neuron synaptic transmission (GO:0007270)3.13811557
85collagen metabolic process (GO:0032963)3.11901977
86synapse assembly (GO:0007416)3.10011540
87chondrocyte development (GO:0002063)3.06866470
88auditory behavior (GO:0031223)3.05849461
89adherens junction assembly (GO:0034333)3.04823407
90regulation of dendritic spine morphogenesis (GO:0061001)3.04684705
91venous blood vessel morphogenesis (GO:0048845)3.02447239
92regulation of excitatory postsynaptic membrane potential (GO:0060079)3.01627675
93positive regulation of blood vessel endothelial cell migration (GO:0043536)3.01313705
94membrane hyperpolarization (GO:0060081)3.01280242
95membrane depolarization during action potential (GO:0086010)3.00457179
96wound healing, spreading of epidermal cells (GO:0035313)3.00349915
97positive regulation of endothelial cell apoptotic process (GO:2000353)3.00169694
98neurotransmitter transport (GO:0006836)3.00038745
99G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.99491760
100cerebellar granule cell differentiation (GO:0021707)2.98809129
101negative regulation of fatty acid transport (GO:2000192)2.98735518
102regulation of postsynaptic membrane potential (GO:0060078)2.98592318
103regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.98573848
104stress fiber assembly (GO:0043149)2.98326402
105collagen catabolic process (GO:0030574)2.98183528
106hemidesmosome assembly (GO:0031581)2.97738213
107positive regulation of fibroblast migration (GO:0010763)2.97455620
108cell migration involved in sprouting angiogenesis (GO:0002042)2.96602983
109focal adhesion assembly (GO:0048041)2.96069960
110cell-substrate adherens junction assembly (GO:0007045)2.96069960
111peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.94157240
112regulation of synapse maturation (GO:0090128)2.93555642
113basement membrane organization (GO:0071711)2.93512348
114regulation of synaptic transmission, glutamatergic (GO:0051966)2.93448992
115synapse organization (GO:0050808)2.92045156
116multicellular organismal macromolecule metabolic process (GO:0044259)2.91520900
117adhesion of symbiont to host cell (GO:0044650)2.90282941
118virion attachment to host cell (GO:0019062)2.90282941
119potassium ion homeostasis (GO:0055075)2.89743739
120dermatan sulfate biosynthetic process (GO:0030208)2.88739936
121positive regulation of synaptic transmission, GABAergic (GO:0032230)2.88552270
122regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.88218717
123neuronal action potential propagation (GO:0019227)2.87790822
124negative regulation of osteoblast proliferation (GO:0033689)2.87542622
125neuronal ion channel clustering (GO:0045161)2.87268020
126transmission of nerve impulse (GO:0019226)2.87170063
127cell communication involved in cardiac conduction (GO:0086065)2.86939881
128dermatan sulfate metabolic process (GO:0030205)2.85966550
129positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.85381063
130regulation of neurotransmitter secretion (GO:0046928)2.83967870
131postsynaptic membrane organization (GO:0001941)2.83421492
132hypotonic response (GO:0006971)2.82189177
133regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.81931724
134regulation of synaptic plasticity (GO:0048167)2.81903640
135extracellular matrix disassembly (GO:0022617)2.81703155
136regulation of ARF protein signal transduction (GO:0032012)2.79998694
137glomerular basement membrane development (GO:0032836)2.79946880
138positive regulation of dendritic spine development (GO:0060999)2.77539962
139cellular response to vitamin (GO:0071295)2.76281283
140potassium ion import (GO:0010107)2.75988263
141axon cargo transport (GO:0008088)2.75503884
142positive regulation of osteoblast proliferation (GO:0033690)2.75480734
143regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.75438243
144regulation of axon extension involved in axon guidance (GO:0048841)2.75307370
145regulation of respiratory system process (GO:0044065)2.74596811
146gamma-aminobutyric acid signaling pathway (GO:0007214)2.73815163
147cellular sodium ion homeostasis (GO:0006883)2.73377393
148multicellular organismal metabolic process (GO:0044236)2.73170301
149negative regulation of chondrocyte differentiation (GO:0032331)2.72540473
150regulation of neurotransmitter levels (GO:0001505)2.72195174
151lymphangiogenesis (GO:0001946)2.71873683
152regulation of respiratory gaseous exchange (GO:0043576)2.71560616
153neuromuscular process controlling posture (GO:0050884)2.70639185
154dopamine receptor signaling pathway (GO:0007212)2.70165943
155multicellular organismal catabolic process (GO:0044243)2.67626547
156membrane depolarization (GO:0051899)2.67552618
157behavioral defense response (GO:0002209)2.67527207
158behavioral fear response (GO:0001662)2.67527207
159planar cell polarity pathway involved in neural tube closure (GO:0090179)2.67365478
160barbed-end actin filament capping (GO:0051016)2.66140111
161fibril organization (GO:0097435)2.66043105
162regulation of extracellular matrix disassembly (GO:0010715)2.65539929
163* homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.65394363
164neuron projection extension involved in neuron projection guidance (GO:1902284)2.65198825
165axon extension involved in axon guidance (GO:0048846)2.65198825
166extracellular matrix organization (GO:0030198)2.65023807
167extracellular structure organization (GO:0043062)2.63938840
168heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.62699858
169endothelial cell morphogenesis (GO:0001886)2.61011096
170actin filament depolymerization (GO:0030042)2.60125467
171protein retention in ER lumen (GO:0006621)2.59808583
172protein localization to cell surface (GO:0034394)2.57832225
173retina vasculature morphogenesis in camera-type eye (GO:0061299)2.57360787
174substrate adhesion-dependent cell spreading (GO:0034446)2.57282403
175cytoskeletal anchoring at plasma membrane (GO:0007016)2.57278132
176regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.56571709
177smooth muscle tissue development (GO:0048745)2.54584560
178negative regulation of BMP signaling pathway (GO:0030514)2.53458543
179vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.51009330
180protein targeting to plasma membrane (GO:0072661)2.49742916
181adhesion of symbiont to host (GO:0044406)2.49644625
182mesodermal cell differentiation (GO:0048333)2.49449941
183muscle cell migration (GO:0014812)2.47445428
184maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.46635799
185cortical actin cytoskeleton organization (GO:0030866)2.46125781
186axon extension (GO:0048675)2.45945602
187regulation of smooth muscle cell migration (GO:0014910)2.45835555
188negative regulation of axon extension involved in axon guidance (GO:0048843)2.45109402
189regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.44185553
190Golgi transport vesicle coating (GO:0048200)2.44018231
191COPI coating of Golgi vesicle (GO:0048205)2.44018231
192apoptotic cell clearance (GO:0043277)2.42812328
193insulin-like growth factor receptor signaling pathway (GO:0048009)2.42240407
194protein localization to endosome (GO:0036010)2.41498510
195regulation of osteoblast proliferation (GO:0033688)2.41256238
196cardiac myofibril assembly (GO:0055003)2.39872377
197extracellular negative regulation of signal transduction (GO:1900116)2.38497276
198extracellular regulation of signal transduction (GO:1900115)2.38497276
199positive regulation of axon extension (GO:0045773)2.38051860

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.95576922
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.13971504
3PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.79267020
4RARG_19884340_ChIP-ChIP_MEFs_Mouse3.32797206
5GBX2_23144817_ChIP-Seq_PC3_Human2.99007675
6* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.95836441
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.92666828
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.78416530
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.70231450
10DROSHA_22980978_ChIP-Seq_HELA_Human2.65930115
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.63209822
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.63209822
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.55015378
14REST_21632747_ChIP-Seq_MESCs_Mouse2.53729691
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.51990823
16* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.50727346
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.44513996
18SMAD_19615063_ChIP-ChIP_OVARY_Human2.43087709
19MTF2_20144788_ChIP-Seq_MESCs_Mouse2.42993422
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.41193445
21CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.40481658
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.39149812
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.37964832
24RARB_27405468_Chip-Seq_BRAIN_Mouse2.37423234
25SUZ12_27294783_Chip-Seq_ESCs_Mouse2.35070679
26TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.33332903
27RNF2_27304074_Chip-Seq_ESCs_Mouse2.29260309
28EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.27131037
29EED_16625203_ChIP-ChIP_MESCs_Mouse2.23848191
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.23194965
31REST_18959480_ChIP-ChIP_MESCs_Mouse2.08927613
32BRD4_25478319_ChIP-Seq_HGPS_Human2.07862198
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.07814645
34RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.06416030
35NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.04984582
36CJUN_26792858_Chip-Seq_BT549_Human1.99900798
37THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.94808739
38ESR2_21235772_ChIP-Seq_MCF-7_Human1.93182589
39WT1_19549856_ChIP-ChIP_CCG9911_Human1.87704267
40AR_21572438_ChIP-Seq_LNCaP_Human1.83774034
41NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.74654435
42CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.74400130
43MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.69992933
44CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.68650795
45GATA2_21666600_ChIP-Seq_HMVEC_Human1.67927545
46TP53_16413492_ChIP-PET_HCT116_Human1.65892563
47NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.65803862
48NRF2_20460467_ChIP-Seq_MEFs_Mouse1.65803862
49CDX2_19796622_ChIP-Seq_MESCs_Mouse1.61740357
50IKZF1_21737484_ChIP-ChIP_HCT116_Human1.59339631
51CLOCK_20551151_ChIP-Seq_293T_Human1.57416735
52TP53_18474530_ChIP-ChIP_U2OS_Human1.53960113
53ZFP281_18757296_ChIP-ChIP_E14_Mouse1.51474331
54SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51409203
55CTBP2_25329375_ChIP-Seq_LNCAP_Human1.48759761
56RING1B_27294783_Chip-Seq_ESCs_Mouse1.47846751
57ELK3_25401928_ChIP-Seq_HUVEC_Human1.47268748
58PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45787155
59PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.45219759
60RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.45120077
61CTNNB1_20460455_ChIP-Seq_HCT116_Human1.43859501
62HIF1A_21447827_ChIP-Seq_MCF-7_Human1.43508245
63SOX9_24532713_ChIP-Seq_HFSC_Mouse1.41849393
64ZNF274_21170338_ChIP-Seq_K562_Hela1.41618176
65TBX20_22328084_ChIP-Seq_HEART_Mouse1.41380745
66TBX20_22080862_ChIP-Seq_HEART_Mouse1.41380745
67IGF1R_20145208_ChIP-Seq_DFB_Human1.41029794
68* TP53_23651856_ChIP-Seq_MEFs_Mouse1.40929856
69NFIB_24661679_ChIP-Seq_LUNG_Mouse1.39699754
70KDM2B_26808549_Chip-Seq_K562_Human1.39060866
71AR_19668381_ChIP-Seq_PC3_Human1.37997233
72SMAD4_21799915_ChIP-Seq_A2780_Human1.37599150
73WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.37064283
74* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.31999694
75RING1B_27294783_Chip-Seq_NPCs_Mouse1.31519700
76WT1_25993318_ChIP-Seq_PODOCYTE_Human1.30855605
77TP53_22127205_ChIP-Seq_IMR90_Human1.28558913
78SOX2_21211035_ChIP-Seq_LN229_Gbm1.28529816
79P300_27058665_Chip-Seq_ZR-75-30cells_Human1.26665220
80RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.26018569
81* ERG_21242973_ChIP-ChIP_JURKAT_Human1.25091985
82DNAJC2_21179169_ChIP-ChIP_NT2_Human1.24464197
83EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.24109129
84PPAR_26484153_Chip-Seq_NCI-H1993_Human1.23435028
85CTBP1_25329375_ChIP-Seq_LNCAP_Human1.23075442
86SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19232277
87SMC1_22415368_ChIP-Seq_MEFs_Mouse1.18724065
88* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.18114987
89* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.18114987
90CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.16370724
91TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.16343757
92NR3C1_23031785_ChIP-Seq_PC12_Mouse1.15891751
93OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.15743946
94SMAD3_21741376_ChIP-Seq_EPCs_Human1.14746140
95NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.13617369
96ZFP281_27345836_Chip-Seq_ESCs_Mouse1.13536800
97TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.12986182
98STAT3_23295773_ChIP-Seq_U87_Human1.12349862
99HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.11509622
100EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.11259979
101YAP1_20516196_ChIP-Seq_MESCs_Mouse1.11162447
102CBX2_27304074_Chip-Seq_ESCs_Mouse1.10780856
103TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.10260004
104ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09422875
105SMAD4_21741376_ChIP-Seq_HESCs_Human1.09210571
106ESR1_21235772_ChIP-Seq_MCF-7_Human1.08928014
107P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06709305
108MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.06317597
109SA1_22415368_ChIP-Seq_MEFs_Mouse1.06150906
110ARNT_22903824_ChIP-Seq_MCF-7_Human1.05149333
111AR_25329375_ChIP-Seq_VCAP_Human1.05014814
112VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.04997414
113ESR1_20079471_ChIP-ChIP_T-47D_Human1.04820089
114DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.04410981
115AHR_22903824_ChIP-Seq_MCF-7_Human1.03879677
116RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.03284038
117SMAD3_21741376_ChIP-Seq_ESCs_Human1.03238662
118JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03049444
119TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02843408
120TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.01855036
121OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01796464
122ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.01685306
123JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01600786
124SMC3_22415368_ChIP-Seq_MEFs_Mouse1.00964715
125PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.00652273
126UBF1/2_26484160_Chip-Seq_HMECs_Human0.99572071
127SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98430488
128PIAS1_25552417_ChIP-Seq_VCAP_Human0.98093863
129BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.97672214
130TET1_21490601_ChIP-Seq_MESCs_Mouse0.97669494
131RNF2_27304074_Chip-Seq_NSC_Mouse0.96987864
132UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.96480066
133SMAD3_21741376_ChIP-Seq_HESCs_Human0.96433512
134NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96032826
135SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.95992667
136MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94748809
137TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94245358
138ELK4_26923725_Chip-Seq_MESODERM_Mouse0.93628483
139P300_19829295_ChIP-Seq_ESCs_Human0.92845617
140ZFP57_27257070_Chip-Seq_ESCs_Mouse0.92594762
141BMI1_23680149_ChIP-Seq_NPCS_Mouse0.92518100
142TCF4_23295773_ChIP-Seq_U87_Human0.89907694
143GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88732887
144TP53_20018659_ChIP-ChIP_R1E_Mouse0.88157302
145KDM2B_26808549_Chip-Seq_SUP-B15_Human0.87870932
146TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86676925
147ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.85223788
148EP300_21415370_ChIP-Seq_HL-1_Mouse0.84943037
149AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.84822585
150ISL1_27105846_Chip-Seq_CPCs_Mouse0.84283278
151TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84247247

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen7.48084608
2MP0004859_abnormal_synaptic_plasticity5.86105394
3MP0003705_abnormal_hypodermis_morpholog4.37639932
4MP0005503_abnormal_tendon_morphology4.20563249
5MP0005275_abnormal_skin_tensile4.11946509
6MP0004272_abnormal_basement_membrane3.89436943
7MP0001958_emphysema3.83877380
8MP0003279_aneurysm3.81682381
9MP0003635_abnormal_synaptic_transmissio3.71654955
10MP0003880_abnormal_central_pattern3.58329731
11MP0004270_analgesia3.40649517
12MP0005257_abnormal_intraocular_pressure3.15952671
13MP0002063_abnormal_learning/memory/cond3.10277765
14MP0005423_abnormal_somatic_nervous2.97482716
15MP0009745_abnormal_behavioral_response2.76406601
16MP0003566_abnormal_cell_adhesion2.66362723
17MP0002064_seizures2.63879460
18MP0009046_muscle_twitch2.57190212
19MP0001486_abnormal_startle_reflex2.48766727
20MP0009384_cardiac_valve_regurgitation2.44731697
21MP0010368_abnormal_lymphatic_system2.39081976
22MP0002572_abnormal_emotion/affect_behav2.37397528
23MP0002734_abnormal_mechanical_nocicepti2.33176380
24MP0001968_abnormal_touch/_nociception2.17705318
25MP0000778_abnormal_nervous_system2.16223236
26MP0009780_abnormal_chondrocyte_physiolo2.11676153
27MP0002272_abnormal_nervous_system2.11410165
28MP0003950_abnormal_plasma_membrane2.02680226
29MP0002909_abnormal_adrenal_gland2.01994334
30MP0003122_maternal_imprinting2.00940035
31MP0001984_abnormal_olfaction2.00152190
32MP0000569_abnormal_digit_pigmentation1.99733884
33MP0002822_catalepsy1.99435516
34MP0006054_spinal_hemorrhage1.99280939
35MP0001440_abnormal_grooming_behavior1.97822070
36MP0000767_abnormal_smooth_muscle1.92180082
37MP0002184_abnormal_innervation1.90545665
38MP0004811_abnormal_neuron_physiology1.89181709
39MP0001542_abnormal_bone_strength1.88425949
40MP0003091_abnormal_cell_migration1.84492130
41MP0002295_abnormal_pulmonary_circulatio1.82260955
42MP0003329_amyloid_beta_deposits1.81182963
43MP0004858_abnormal_nervous_system1.81143634
44MP0005551_abnormal_eye_electrophysiolog1.79825774
45MP0002733_abnormal_thermal_nociception1.78885293
46MP0002557_abnormal_social/conspecific_i1.75507011
47MP0005508_abnormal_skeleton_morphology1.75234558
48MP0008569_lethality_at_weaning1.74922817
49MP0002067_abnormal_sensory_capabilities1.69058464
50MP0006276_abnormal_autonomic_nervous1.67632658
51MP0002108_abnormal_muscle_morphology1.67410669
52MP0001970_abnormal_pain_threshold1.65278880
53MP0000751_myopathy1.64805098
54MP0008961_abnormal_basal_metabolism1.63121951
55MP0001501_abnormal_sleep_pattern1.61679029
56MP0000955_abnormal_spinal_cord1.61062041
57MP0005409_darkened_coat_color1.60864008
58MP0004885_abnormal_endolymph1.59857131
59MP0005023_abnormal_wound_healing1.59746039
60MP0002882_abnormal_neuron_morphology1.54604662
61MP0002896_abnormal_bone_mineralization1.53817885
62MP0001502_abnormal_circadian_rhythm1.53649923
63MP0002060_abnormal_skin_morphology1.51850295
64MP0002735_abnormal_chemical_nociception1.47313505
65MP0004924_abnormal_behavior1.47304937
66MP0005386_behavior/neurological_phenoty1.47304937
67MP0004233_abnormal_muscle_weight1.39040234
68MP0002736_abnormal_nociception_after1.36537916
69MP0000013_abnormal_adipose_tissue1.35242462
70MP0000733_abnormal_muscle_development1.31142684
71MP0010352_gastrointestinal_tract_polyps1.31093357
72MP0002066_abnormal_motor_capabilities/c1.29803730
73MP0002653_abnormal_ependyma_morphology1.28228747
74MP0005623_abnormal_meninges_morphology1.27633761
75MP0002152_abnormal_brain_morphology1.26943252
76MP0009250_abnormal_appendicular_skeleto1.26302255
77MP0005595_abnormal_vascular_smooth1.26113895
78MP0002877_abnormal_melanocyte_morpholog1.24589887
79MP0003941_abnormal_skin_development1.22704191
80MP0001529_abnormal_vocalization1.22061169
81MP0004084_abnormal_cardiac_muscle1.20654056
82MP0003283_abnormal_digestive_organ1.20411244
83MP0004145_abnormal_muscle_electrophysio1.18797158
84MP0003633_abnormal_nervous_system1.18309932
85MP0001879_abnormal_lymphatic_vessel1.17517604
86MP0002090_abnormal_vision1.16976527
87MP0005645_abnormal_hypothalamus_physiol1.16809781
88MP0003137_abnormal_impulse_conducting1.16364898
89MP0004215_abnormal_myocardial_fiber1.13464380
90MP0002638_abnormal_pupillary_reflex1.12998749
91MP0003879_abnormal_hair_cell1.12967379
92MP0003942_abnormal_urinary_system1.12280992
93MP0000749_muscle_degeneration1.11557822
94MP0001299_abnormal_eye_distance/1.11209446
95MP0004036_abnormal_muscle_relaxation1.10172774
96MP0000428_abnormal_craniofacial_morphol1.08492757
97MP0003634_abnormal_glial_cell1.08271892
98MP0000462_abnormal_digestive_system1.06844830
99MP0005646_abnormal_pituitary_gland1.06666819
100MP0000759_abnormal_skeletal_muscle1.05079754
101MP0001177_atelectasis1.05048813
102MP0001243_abnormal_dermal_layer1.04622749
103MP0010386_abnormal_urinary_bladder1.04500618
104MP0004085_abnormal_heartbeat1.03091178
105MP0003631_nervous_system_phenotype1.01723824
106MP0006072_abnormal_retinal_apoptosis0.98759623
107MP0002229_neurodegeneration0.98702025
108MP0001348_abnormal_lacrimal_gland0.98155168
109MP0000003_abnormal_adipose_tissue0.98036850
110MP0000631_abnormal_neuroendocrine_gland0.96889634
111MP0003787_abnormal_imprinting0.96180761
112MP0002089_abnormal_postnatal_growth/wei0.96103450
113MP0004142_abnormal_muscle_tone0.94489939
114MP0000762_abnormal_tongue_morphology0.94296342
115MP0004134_abnormal_chest_morphology0.93846532
116MP0006138_congestive_heart_failure0.93750200
117MP0000534_abnormal_ureter_morphology0.91872954
118MP0003385_abnormal_body_wall0.91772003
119MP0002752_abnormal_somatic_nervous0.89884321
120MP0002168_other_aberrant_phenotype0.89595348
121MP0000163_abnormal_cartilage_morphology0.89426526
122MP0002069_abnormal_eating/drinking_beha0.89250539
123MP0005253_abnormal_eye_physiology0.89217637
124MP0002128_abnormal_blood_circulation0.88719308
125MP0004742_abnormal_vestibular_system0.86715889
126MP0003861_abnormal_nervous_system0.86365380
127MP0009053_abnormal_anal_canal0.85782248
128MP0005187_abnormal_penis_morphology0.85664502
129MP0009840_abnormal_foam_cell0.83783799
130MP0005164_abnormal_response_to0.82353631
131MP0003632_abnormal_nervous_system0.81406548
132MP0000750_abnormal_muscle_regeneration0.81244943
133MP0005390_skeleton_phenotype0.80965363
134MP0005197_abnormal_uvea_morphology0.79511603
135MP0001614_abnormal_blood_vessel0.79372906
136MP0004510_myositis0.78588169
137MP0005171_absent_coat_pigmentation0.78316273
138MP0001915_intracranial_hemorrhage0.78118668
139MP0003121_genomic_imprinting0.76844616
140MP0005620_abnormal_muscle_contractility0.76470474
141MP0002127_abnormal_cardiovascular_syste0.75816431
142MP0000538_abnormal_urinary_bladder0.75738871
143MP0002249_abnormal_larynx_morphology0.75550493
144MP0002115_abnormal_skeleton_extremities0.75334745
145MP0000432_abnormal_head_morphology0.75286664
146MP0003115_abnormal_respiratory_system0.74952681
147MP0004087_abnormal_muscle_fiber0.74569958
148MP0003690_abnormal_glial_cell0.71528313
149MP0000604_amyloidosis0.71267793
150MP0002925_abnormal_cardiovascular_devel0.68839298
151MP0005369_muscle_phenotype0.68160744
152MP0003890_abnormal_embryonic-extraembry0.68125155
153MP0003935_abnormal_craniofacial_develop0.67981622
154MP0003868_abnormal_feces_composition0.66504823
155MP0000920_abnormal_myelination0.66503186
156MP0002933_joint_inflammation0.65484386
157MP0005248_abnormal_Harderian_gland0.65035132
158MP0001943_abnormal_respiration0.64013395
159MP0005195_abnormal_posterior_eye0.63419566
160MP0002116_abnormal_craniofacial_bone0.63213274
161MP0002133_abnormal_respiratory_system0.62911502
162MP0005388_respiratory_system_phenotype0.62911502
163MP0001963_abnormal_hearing_physiology0.62688109
164MP0010030_abnormal_orbit_morphology0.62385507
165MP0001175_abnormal_lung_morphology0.62221345
166MP0010769_abnormal_survival0.61807326
167MP0005165_increased_susceptibility_to0.61745639
168MP0003191_abnormal_cellular_cholesterol0.61704943
169MP0001849_ear_inflammation0.61511196
170MP0002082_postnatal_lethality0.60713462
171MP0010770_preweaning_lethality0.60713462
172MP0004130_abnormal_muscle_cell0.60595309
173MP0002113_abnormal_skeleton_development0.60015959
174MP0000049_abnormal_middle_ear0.59618784
175MP0000747_muscle_weakness0.58994390
176MP0002114_abnormal_axial_skeleton0.58829983
177MP0004133_heterotaxia0.58298892
178MP0003755_abnormal_palate_morphology0.58205491
179MP0003045_fibrosis0.58029698
180MP0001905_abnormal_dopamine_level0.57630597
181MP0002932_abnormal_joint_morphology0.56861941
182MP0002998_abnormal_bone_remodeling0.54362740

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)6.86385374
2Protrusio acetabuli (HP:0003179)6.78882990
3Myokymia (HP:0002411)5.40056636
4Aortic aneurysm (HP:0004942)5.36307822
5Focal motor seizures (HP:0011153)5.07560021
6Aortic dissection (HP:0002647)5.05630058
7Vascular tortuosity (HP:0004948)4.53004397
8Focal seizures (HP:0007359)4.37629209
9Ankle contracture (HP:0006466)4.37237297
10Follicular hyperkeratosis (HP:0007502)4.20982857
11Arterial tortuosity (HP:0005116)4.08100990
12Type 1 muscle fiber predominance (HP:0003803)4.06763871
13Visual hallucinations (HP:0002367)4.01878360
14Bladder diverticulum (HP:0000015)3.97567564
15Soft skin (HP:0000977)3.87814319
16Abnormality of dentin (HP:0010299)3.86195569
17Epileptic encephalopathy (HP:0200134)3.77749513
18Spinal rigidity (HP:0003306)3.76091645
19Action tremor (HP:0002345)3.64765150
20Progressive cerebellar ataxia (HP:0002073)3.60643934
21Atrophic scars (HP:0001075)3.58309066
22Wormian bones (HP:0002645)3.50330189
23Ankle clonus (HP:0011448)3.43343501
24Cervical subluxation (HP:0003308)3.39970565
25Neonatal short-limb short stature (HP:0008921)3.30704920
26Spondylolisthesis (HP:0003302)3.30526718
27Overgrowth (HP:0001548)3.13407561
28Depression (HP:0000716)3.12078469
29Slender build (HP:0001533)3.11467211
30Fragile skin (HP:0001030)3.07596460
31Central scotoma (HP:0000603)3.05699250
32Febrile seizures (HP:0002373)3.05126238
33Supranuclear gaze palsy (HP:0000605)3.02622287
34Polyphagia (HP:0002591)3.00928627
35Increased variability in muscle fiber diameter (HP:0003557)2.99593601
36Abnormal eating behavior (HP:0100738)2.98729418
37Dilatation of the ascending aorta (HP:0005111)2.96184137
38Mutism (HP:0002300)2.95497684
39Congenital stationary night blindness (HP:0007642)2.95450784
40Genu recurvatum (HP:0002816)2.93541740
41Genetic anticipation (HP:0003743)2.92863071
42Absence seizures (HP:0002121)2.91658992
43Mitral valve prolapse (HP:0001634)2.90895187
44Cerebral aneurysm (HP:0004944)2.90288770
45Blue sclerae (HP:0000592)2.86235905
46Bowel diverticulosis (HP:0005222)2.83106259
47Joint laxity (HP:0001388)2.82713491
48Hemiparesis (HP:0001269)2.81604456
49Truncal ataxia (HP:0002078)2.80787957
50Dysdiadochokinesis (HP:0002075)2.80289328
51Aortic regurgitation (HP:0001659)2.77514343
52Impaired vibration sensation in the lower limbs (HP:0002166)2.73056325
53Poor eye contact (HP:0000817)2.72034051
54Hemiplegia (HP:0002301)2.70994225
55Vertebral compression fractures (HP:0002953)2.70174712
56Aneurysm (HP:0002617)2.67040996
57Mildly elevated creatine phosphokinase (HP:0008180)2.66694872
58Generalized tonic-clonic seizures (HP:0002069)2.64650477
59Obstructive sleep apnea (HP:0002870)2.62860348
60Abnormal social behavior (HP:0012433)2.61939146
61Impaired social interactions (HP:0000735)2.61939146
62Broad-based gait (HP:0002136)2.60990349
63Papilledema (HP:0001085)2.58823483
64Hyperextensible skin (HP:0000974)2.58156334
65Failure to thrive in infancy (HP:0001531)2.57547563
66Biconcave vertebral bodies (HP:0004586)2.56444709
67Short nail (HP:0001799)2.54345441
68Abnormality of skeletal muscle fiber size (HP:0012084)2.53452118
69Dialeptic seizures (HP:0011146)2.52814530
70Urinary urgency (HP:0000012)2.50607841
71Urinary bladder sphincter dysfunction (HP:0002839)2.50458924
72Drooling (HP:0002307)2.49620302
73Excessive salivation (HP:0003781)2.49620302
74Torticollis (HP:0000473)2.48449789
75Peritonitis (HP:0002586)2.47822663
76Wide anterior fontanel (HP:0000260)2.47505892
77Hypoventilation (HP:0002791)2.47110614
78Abnormality of the lower motor neuron (HP:0002366)2.46576902
79Osteolytic defects of the phalanges of the hand (HP:0009771)2.44848035
80Osteolytic defects of the hand bones (HP:0009699)2.44848035
81Mitral regurgitation (HP:0001653)2.40629549
82Spastic gait (HP:0002064)2.39700996
83Agitation (HP:0000713)2.38202770
84Mild short stature (HP:0003502)2.37447708
85Atonic seizures (HP:0010819)2.36599045
86Limb dystonia (HP:0002451)2.36480057
87Scotoma (HP:0000575)2.36298374
88Neoplasm of the heart (HP:0100544)2.35873769
89Anxiety (HP:0000739)2.35552721
90Gaze-evoked nystagmus (HP:0000640)2.33657162
91Megalencephaly (HP:0001355)2.32761863
92Insomnia (HP:0100785)2.30273420
93Postural instability (HP:0002172)2.27303386
94Dysmetria (HP:0001310)2.26347375
95Aortic valve stenosis (HP:0001650)2.21546851
96Disproportionate tall stature (HP:0001519)2.21296248
97Pointed chin (HP:0000307)2.20504720
98Elbow flexion contracture (HP:0002987)2.18508480
99Intention tremor (HP:0002080)2.17360319
100Scanning speech (HP:0002168)2.16697191
101Increased connective tissue (HP:0009025)2.16485385
102Insidious onset (HP:0003587)2.15806848
103Termporal pattern (HP:0011008)2.15806848
104Amblyopia (HP:0000646)2.14135023
105Abnormality of the corticospinal tract (HP:0002492)2.13331411
106Impaired smooth pursuit (HP:0007772)2.13189380
107EEG with generalized epileptiform discharges (HP:0011198)2.11622980
108Pheochromocytoma (HP:0002666)2.11515462
109Lower limb muscle weakness (HP:0007340)2.10934981
110Neurofibrillary tangles (HP:0002185)2.10828260
111Round ear (HP:0100830)2.09621717
112Broad face (HP:0000283)2.09267509
113Abnormality of macular pigmentation (HP:0008002)2.09205002
114Epileptiform EEG discharges (HP:0011182)2.07862001
115Joint stiffness (HP:0001387)2.07422812
116Focal dystonia (HP:0004373)2.07135446
117Natal tooth (HP:0000695)2.07031919
118Abnormality of the acetabulum (HP:0003170)2.05107019
119Amyotrophic lateral sclerosis (HP:0007354)2.04164805
120Upper limb amyotrophy (HP:0009129)2.03901901
121Distal upper limb amyotrophy (HP:0007149)2.03901901
122Hypsarrhythmia (HP:0002521)2.02717680
123Wrist flexion contracture (HP:0001239)2.02544380
124Abnormality of ocular smooth pursuit (HP:0000617)2.01811468
125Diplopia (HP:0000651)1.99968467
126Abnormality of binocular vision (HP:0011514)1.99968467
127Hyperacusis (HP:0010780)1.99592920
128Elfin facies (HP:0004428)1.99503851
129Long toe (HP:0010511)1.99220662
130Ulnar bowing (HP:0003031)1.97941149
131Protruding ear (HP:0000411)1.97552137
132Dysmetric saccades (HP:0000641)1.95295686
133Abnormal delivery (HP:0001787)1.94805159
134Ectopia lentis (HP:0001083)1.94228918
135Distal lower limb amyotrophy (HP:0008944)1.94015297
136Cerebral inclusion bodies (HP:0100314)1.92972295
137Broad ribs (HP:0000885)1.92873914
138Craniofacial dystonia (HP:0012179)1.92330283
139Prolonged QT interval (HP:0001657)1.91276974
140Abnormal EKG (HP:0003115)1.90709832
141Coronal craniosynostosis (HP:0004440)1.90017523
142Mitral stenosis (HP:0001718)1.88744253
143Stereotypic behavior (HP:0000733)1.88570036
144Hypoplasia of the brainstem (HP:0002365)1.87398129
145Aplasia/Hypoplasia of the brainstem (HP:0007362)1.87398129
146Bradykinesia (HP:0002067)1.86512748
147Hypoplasia of the iris (HP:0007676)1.86190489
148Ventricular fibrillation (HP:0001663)1.84745334
149Broad metatarsal (HP:0001783)1.84401795
150Ovoid vertebral bodies (HP:0003300)1.83865021
151Camptodactyly of toe (HP:0001836)1.82538523
152Generalized amyotrophy (HP:0003700)1.82102436
153Bony spicule pigmentary retinopathy (HP:0007737)1.82059272
154Shallow orbits (HP:0000586)1.81811326
155Ankyloglossia (HP:0010296)1.81777297
156Pulmonary artery stenosis (HP:0004415)1.81616046
157Exotropia (HP:0000577)1.81501551
158Aplasia involving bones of the extremities (HP:0009825)1.81409627
159Aplasia involving bones of the upper limbs (HP:0009823)1.81409627
160Aplasia of the phalanges of the hand (HP:0009802)1.81409627
161Cardiovascular calcification (HP:0011915)1.81273020
162Open mouth (HP:0000194)1.80355531
163Progressive inability to walk (HP:0002505)1.80316191
164Specific learning disability (HP:0001328)1.79001353
165Astrocytoma (HP:0009592)1.78629904
166Abnormality of the astrocytes (HP:0100707)1.78629904
167Narrow nasal bridge (HP:0000446)1.77674127
168Premature skin wrinkling (HP:0100678)1.77534852
169Macroorchidism (HP:0000053)1.77410996
170Lower limb amyotrophy (HP:0007210)1.76226005
171Sleep apnea (HP:0010535)1.75939623
172Infantile muscular hypotonia (HP:0008947)1.75104557
173Aqueductal stenosis (HP:0002410)1.73698654
174Bradycardia (HP:0001662)1.72770238
175Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.72542704
176Inguinal hernia (HP:0000023)1.71290287
177Asymmetric septal hypertrophy (HP:0001670)1.69696509
178Achilles tendon contracture (HP:0001771)1.69488199
179Tibial bowing (HP:0002982)1.67122099
180Arachnodactyly (HP:0001166)1.66605245
181Coxa vara (HP:0002812)1.66442160
182Flared iliac wings (HP:0002869)1.66005413
183Absent frontal sinuses (HP:0002688)1.65771427
184Hydroureter (HP:0000072)1.65571689
185Flat cornea (HP:0007720)1.64618290
186Limited hip movement (HP:0008800)1.64477609
187Spinal cord lesions (HP:0100561)1.63098367
188Syringomyelia (HP:0003396)1.63098367
189Congenital glaucoma (HP:0001087)1.62505785
190Hand muscle atrophy (HP:0009130)1.62236424
191Limb-girdle muscle weakness (HP:0003325)1.62041340
192Deviation of the hallux (HP:0010051)1.61997865
193Abnormality of skull ossification (HP:0002703)1.61862087
194Delayed cranial suture closure (HP:0000270)1.61641232
195Hallux valgus (HP:0001822)1.61083647
196Osteoarthritis (HP:0002758)1.60856718

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.90409858
2MYLK4.65846386
3MARK14.40190028
4TTN3.32928689
5NTRK33.27206638
6NTRK22.95128898
7PAK62.79390275
8EPHA42.75947789
9MINK12.63555867
10FGFR22.34267106
11MAP3K42.33913030
12NEK92.12059361
13PAK22.07838911
14CAMKK12.07005892
15TYRO32.06337517
16PRKD32.03496413
17KSR12.01716917
18TGFBR22.00453221
19SIK31.98989593
20TESK11.84478395
21SIK11.76197412
22UHMK11.72202287
23DAPK21.67945878
24ERN11.67222339
25PHKG11.66399182
26PHKG21.66399182
27TIE11.61519895
28PRKD21.56973927
29KSR21.54616130
30PRPF4B1.53802817
31AKT31.46775929
32CDK51.45532666
33MAPK131.44243810
34LATS11.44190156
35SIK21.42989968
36MAP2K71.42339755
37MET1.40192586
38CDK121.37405470
39MAP2K41.36847420
40NTRK11.33354902
41BCR1.26832286
42PDGFRA1.25382451
43ERBB31.21781089
44MTOR1.20169216
45MAP3K61.16235124
46TRPM71.15860119
47CAMKK21.14912206
48PAK31.14893376
49CDK191.14549151
50MOS1.12895224
51RIPK11.12657468
52RET1.12041327
53STK381.11938226
54LATS21.10609584
55PAK41.09648877
56WNK11.09162441
57LMTK21.05795905
58CDK181.05632149
59TNIK1.05407763
60PKN21.02189546
61PIK3CG0.98624774
62ERBB40.98499370
63CDK150.96066570
64PTK2B0.94320338
65FLT30.93385373
66CDK140.93066262
67CAMK1G0.92089786
68PRKCG0.90768914
69MAP3K120.86286773
70MAPK70.86282584
71MARK20.84852754
72ARAF0.83353022
73CDK11A0.82617884
74PRKCH0.81612433
75DYRK20.79891728
76DYRK1A0.79321141
77EPHA30.78908342
78ICK0.76876481
79DMPK0.76548249
80STK110.76367682
81CAMK10.76034812
82EPHB10.75626693
83ADRBK10.74216416
84CDC42BPA0.72648826
85IRAK20.70787484
86NEK10.70403801
87MAP2K10.70120287
88SGK2230.69886146
89SGK4940.69886146
90DAPK30.69804659
91FGFR40.69451805
92DDR20.68511477
93TAOK10.68489774
94FGFR10.67831739
95GRK70.67091560
96MAP3K130.66600261
97FER0.66308691
98PINK10.65822492
99MELK0.64651513
100LIMK10.64047470
101PRKG20.63495446
102MAP3K20.63383021
103CAMK2G0.63104642
104INSRR0.61588933
105ABL20.61364116
106CAMK2A0.61335800
107JAK10.60577764
108DAPK10.60461489
109TRIB30.60362303
110GSK3A0.56473990
111PRKCZ0.56324552
112PRKD10.55817686
113EPHB20.55781377
114PNCK0.55347492
115FES0.55186114
116CSNK1G20.55052535
117PLK20.54628489
118CAMK40.51705933
119FYN0.51413325
120MAP3K70.51267924
121FGFR30.51243369
122ALK0.49467960
123ROCK10.49426449
124CAMK2B0.48038107
125SGK10.48000979
126CAMK2D0.47592365
127ILK0.47368099
128GRK10.47270141
129STK38L0.47177428
130WNK30.47133208
131KIT0.45875559
132CAMK1D0.45700395
133RPS6KA30.45615944
134MAPK100.45605101
135ERBB20.45579959
136SGK30.44212815
137CDK80.42965123
138GRK50.42239066
139PIK3CA0.41398623
140RPS6KA20.40367585
141DYRK1B0.39569371
142SCYL20.39415120
143PDPK10.38869147
144SGK20.38427462
145MAPK90.36786137
146SRC0.35535595
147PDGFRB0.35382602
148PRKCE0.34848996
149ROCK20.34515823
150PTK20.34481282
151EEF2K0.34019293
152EPHA20.33928236
153MAPK40.32945671
154RPS6KL10.31943941
155RPS6KC10.31943941
156PRKAA10.31126334
157HIPK20.30499482
158PIM20.30055124

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.68623261
2Nicotine addiction_Homo sapiens_hsa050333.13788539
3Synaptic vesicle cycle_Homo sapiens_hsa047212.86067774
4GABAergic synapse_Homo sapiens_hsa047272.60327240
5Circadian entrainment_Homo sapiens_hsa047132.46471976
6Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.39873645
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.31533881
8Morphine addiction_Homo sapiens_hsa050322.23871938
9Olfactory transduction_Homo sapiens_hsa047402.23092409
10Glutamatergic synapse_Homo sapiens_hsa047242.21672955
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.05973136
12Insulin secretion_Homo sapiens_hsa049112.03607197
13Glycosaminoglycan degradation_Homo sapiens_hsa005312.03396176
14Dopaminergic synapse_Homo sapiens_hsa047281.98505439
15Long-term potentiation_Homo sapiens_hsa047201.95718538
16Cholinergic synapse_Homo sapiens_hsa047251.93957890
17Amphetamine addiction_Homo sapiens_hsa050311.79204929
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.78105434
19Salivary secretion_Homo sapiens_hsa049701.78093501
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.77233936
21Protein digestion and absorption_Homo sapiens_hsa049741.74280314
22Oxytocin signaling pathway_Homo sapiens_hsa049211.58521674
23Amoebiasis_Homo sapiens_hsa051461.58158822
24AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.57385662
25Renin secretion_Homo sapiens_hsa049241.55113586
26Regulation of actin cytoskeleton_Homo sapiens_hsa048101.54914482
27Gastric acid secretion_Homo sapiens_hsa049711.53017045
28Cocaine addiction_Homo sapiens_hsa050301.52681126
29Axon guidance_Homo sapiens_hsa043601.50368320
30Gap junction_Homo sapiens_hsa045401.50032230
31Adherens junction_Homo sapiens_hsa045201.47146782
32Phototransduction_Homo sapiens_hsa047441.43131453
33Type II diabetes mellitus_Homo sapiens_hsa049301.42160847
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.41954905
35GnRH signaling pathway_Homo sapiens_hsa049121.39925787
36Taste transduction_Homo sapiens_hsa047421.37431402
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.34709771
38Melanoma_Homo sapiens_hsa052181.34191337
39Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.33626768
40Calcium signaling pathway_Homo sapiens_hsa040201.31348409
41Serotonergic synapse_Homo sapiens_hsa047261.30132873
42Long-term depression_Homo sapiens_hsa047301.29340431
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.28234818
44Small cell lung cancer_Homo sapiens_hsa052221.26445406
45PI3K-Akt signaling pathway_Homo sapiens_hsa041511.24205155
46MicroRNAs in cancer_Homo sapiens_hsa052061.22959354
47Bladder cancer_Homo sapiens_hsa052191.22530003
48Dilated cardiomyopathy_Homo sapiens_hsa054141.21889094
49Glioma_Homo sapiens_hsa052141.17155954
50cAMP signaling pathway_Homo sapiens_hsa040241.15661735
51ErbB signaling pathway_Homo sapiens_hsa040121.15207591
52Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.14672502
53Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.13235166
54Estrogen signaling pathway_Homo sapiens_hsa049151.06765905
55Chronic myeloid leukemia_Homo sapiens_hsa052201.06315587
56TGF-beta signaling pathway_Homo sapiens_hsa043501.05722990
57Nitrogen metabolism_Homo sapiens_hsa009101.04930225
58Phosphatidylinositol signaling system_Homo sapiens_hsa040701.03988055
59cGMP-PKG signaling pathway_Homo sapiens_hsa040221.03777314
60Pathways in cancer_Homo sapiens_hsa052000.98992572
61Melanogenesis_Homo sapiens_hsa049160.97413393
62Phospholipase D signaling pathway_Homo sapiens_hsa040720.96858794
63Circadian rhythm_Homo sapiens_hsa047100.93472079
64Prostate cancer_Homo sapiens_hsa052150.88880133
65Thyroid hormone signaling pathway_Homo sapiens_hsa049190.87959867
66Lysine degradation_Homo sapiens_hsa003100.87565382
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.87454367
68Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.86177524
69mTOR signaling pathway_Homo sapiens_hsa041500.85086080
70Cardiac muscle contraction_Homo sapiens_hsa042600.84756133
71Endometrial cancer_Homo sapiens_hsa052130.82734073
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80574128
73Oocyte meiosis_Homo sapiens_hsa041140.80369053
74Carbohydrate digestion and absorption_Homo sapiens_hsa049730.79018130
75Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.78532976
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78311647
77MAPK signaling pathway_Homo sapiens_hsa040100.78075512
78Other glycan degradation_Homo sapiens_hsa005110.77626519
79Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.77160799
80VEGF signaling pathway_Homo sapiens_hsa043700.76163631
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.75519189
82Notch signaling pathway_Homo sapiens_hsa043300.75087375
83Pancreatic cancer_Homo sapiens_hsa052120.74326719
84Choline metabolism in cancer_Homo sapiens_hsa052310.74306970
85Vibrio cholerae infection_Homo sapiens_hsa051100.72934608
86Platelet activation_Homo sapiens_hsa046110.72570562
87Renal cell carcinoma_Homo sapiens_hsa052110.71203894
88Rap1 signaling pathway_Homo sapiens_hsa040150.68704647
89Leukocyte transendothelial migration_Homo sapiens_hsa046700.68578161
90Collecting duct acid secretion_Homo sapiens_hsa049660.68159621
91Dorso-ventral axis formation_Homo sapiens_hsa043200.67900453
92Thyroid hormone synthesis_Homo sapiens_hsa049180.67789835
93Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.66609918
94Pancreatic secretion_Homo sapiens_hsa049720.66247442
95Ras signaling pathway_Homo sapiens_hsa040140.66071145
96Complement and coagulation cascades_Homo sapiens_hsa046100.65449557
97Endocytosis_Homo sapiens_hsa041440.64899227
98Hippo signaling pathway_Homo sapiens_hsa043900.64869279
99Colorectal cancer_Homo sapiens_hsa052100.64522909
100Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.63286677
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62819825
102Wnt signaling pathway_Homo sapiens_hsa043100.62782126
103Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62512936
104Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61293942
105Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60771657
106Thyroid cancer_Homo sapiens_hsa052160.60328587
107Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.58965131
108Insulin signaling pathway_Homo sapiens_hsa049100.58141586
109Alcoholism_Homo sapiens_hsa050340.57945319
110Inositol phosphate metabolism_Homo sapiens_hsa005620.57890571
111Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57677541
112Glucagon signaling pathway_Homo sapiens_hsa049220.57640976
113Non-small cell lung cancer_Homo sapiens_hsa052230.55528833
114Sphingolipid signaling pathway_Homo sapiens_hsa040710.54060890
115Bile secretion_Homo sapiens_hsa049760.52206076
116Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.52014973
117Hedgehog signaling pathway_Homo sapiens_hsa043400.51665845
118Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50188337
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.50093233
120Prion diseases_Homo sapiens_hsa050200.48368757
121Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.47808774
122Proteoglycans in cancer_Homo sapiens_hsa052050.47433168
123Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46148489
124Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44601360
125Basal cell carcinoma_Homo sapiens_hsa052170.43398616
126Tight junction_Homo sapiens_hsa045300.40232884
127Focal adhesion_Homo sapiens_hsa045100.40088412
128AMPK signaling pathway_Homo sapiens_hsa041520.38507649

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