PCDHGA3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)5.42940327
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.33808754
3synaptic vesicle maturation (GO:0016188)5.15103477
4vocalization behavior (GO:0071625)5.04228103
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.01988077
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.89892611
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.82416078
8synaptic vesicle exocytosis (GO:0016079)4.64100880
9layer formation in cerebral cortex (GO:0021819)4.57270871
10synaptic vesicle docking involved in exocytosis (GO:0016081)4.51236985
11protein localization to synapse (GO:0035418)4.46533329
12glutamate secretion (GO:0014047)4.34410276
13regulation of glutamate receptor signaling pathway (GO:1900449)4.34150782
14dendritic spine morphogenesis (GO:0060997)4.27933417
15regulation of synapse structural plasticity (GO:0051823)4.26139356
16regulation of synaptic vesicle exocytosis (GO:2000300)4.24686258
17exploration behavior (GO:0035640)4.23278798
18ionotropic glutamate receptor signaling pathway (GO:0035235)4.20296175
19neuron cell-cell adhesion (GO:0007158)4.11674139
20regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.03151765
21regulation of long-term neuronal synaptic plasticity (GO:0048169)4.00242842
22positive regulation of synapse maturation (GO:0090129)3.95969731
23neurotransmitter-gated ion channel clustering (GO:0072578)3.91655633
24dendrite morphogenesis (GO:0048813)3.90668561
25synaptic transmission, glutamatergic (GO:0035249)3.90131207
26regulation of neuronal synaptic plasticity (GO:0048168)3.86982688
27regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.84691935
28axonal fasciculation (GO:0007413)3.75893311
29establishment of nucleus localization (GO:0040023)3.75185174
30central nervous system projection neuron axonogenesis (GO:0021952)3.74548795
31glutamate receptor signaling pathway (GO:0007215)3.71217057
32regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.70871288
33neuron recognition (GO:0008038)3.70677489
34regulation of synaptic vesicle transport (GO:1902803)3.70160849
35neurotransmitter secretion (GO:0007269)3.64757646
36pyrimidine nucleobase catabolic process (GO:0006208)3.62294395
37neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.58431570
38innervation (GO:0060384)3.56205265
39neuron-neuron synaptic transmission (GO:0007270)3.56050447
40dermatan sulfate biosynthetic process (GO:0030208)3.53506079
41cerebellar Purkinje cell layer development (GO:0021680)3.52621814
42regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.51327240
43membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.46739868
44regulation of excitatory postsynaptic membrane potential (GO:0060079)3.46328848
45response to pheromone (GO:0019236)3.44709261
46sodium ion export (GO:0071436)3.44560974
47synaptic vesicle endocytosis (GO:0048488)3.42367844
48positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.41873537
49cellular potassium ion homeostasis (GO:0030007)3.38647774
50cell communication by electrical coupling (GO:0010644)3.37290263
51negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.35562546
52regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.35434654
53dermatan sulfate metabolic process (GO:0030205)3.34716524
54cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.33869912
55regulation of postsynaptic membrane potential (GO:0060078)3.32575026
56regulation of dendritic spine morphogenesis (GO:0061001)3.32434776
57neuronal action potential propagation (GO:0019227)3.32099385
58long-term memory (GO:0007616)3.32031297
59cell communication involved in cardiac conduction (GO:0086065)3.31152402
60auditory behavior (GO:0031223)3.29783184
61cell migration in hindbrain (GO:0021535)3.24056482
62positive regulation of membrane potential (GO:0045838)3.23498820
63peripheral nervous system axon ensheathment (GO:0032292)3.21387784
64myelination in peripheral nervous system (GO:0022011)3.21387784
65response to auditory stimulus (GO:0010996)3.21250224
66proline transport (GO:0015824)3.20544602
67gamma-aminobutyric acid transport (GO:0015812)3.18628990
68cardiac myofibril assembly (GO:0055003)3.17031295
69neuromuscular process controlling balance (GO:0050885)3.14522516
70postsynaptic membrane organization (GO:0001941)3.12640266
71activation of protein kinase A activity (GO:0034199)3.12365907
72membrane hyperpolarization (GO:0060081)3.09632391
73cerebellar Purkinje cell differentiation (GO:0021702)3.07008752
74cerebellar granule cell differentiation (GO:0021707)3.06663531
75chondroitin sulfate catabolic process (GO:0030207)3.06625659
76regulation of synaptic transmission, glutamatergic (GO:0051966)3.05807193
77regulation of synaptic plasticity (GO:0048167)3.04611913
78positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.02040678
79clathrin coat assembly (GO:0048268)3.00003364
80positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.97641451
81dendritic spine organization (GO:0097061)2.94414818
82transmission of nerve impulse (GO:0019226)2.94223272
83long-term synaptic potentiation (GO:0060291)2.93864198
84regulation of synapse maturation (GO:0090128)2.89919370
85positive regulation of synaptic transmission, GABAergic (GO:0032230)2.89603196
86regulation of actin filament-based movement (GO:1903115)2.89360671
87nucleobase catabolic process (GO:0046113)2.89267834
88central nervous system neuron axonogenesis (GO:0021955)2.88417868
89cardiac muscle contraction (GO:0060048)2.87828107
90regulation of neurotransmitter secretion (GO:0046928)2.87673080
91synapse assembly (GO:0007416)2.86468183
92neurotransmitter transport (GO:0006836)2.84677903
93axon extension (GO:0048675)2.84497678
94membrane depolarization (GO:0051899)2.84244015
95positive regulation of dendritic spine morphogenesis (GO:0061003)2.83186782
96collagen fibril organization (GO:0030199)2.83055976
97synapse organization (GO:0050808)2.82178408
98G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.81023451
99behavioral fear response (GO:0001662)2.80761807
100behavioral defense response (GO:0002209)2.80761807
101negative regulation of cytosolic calcium ion concentration (GO:0051481)2.79450295
102gamma-aminobutyric acid signaling pathway (GO:0007214)2.79057378
103extracellular matrix assembly (GO:0085029)2.78642837
104neuromuscular process (GO:0050905)2.77323545
105membrane depolarization during action potential (GO:0086010)2.77299490
106positive regulation of dendritic spine development (GO:0060999)2.77056623
107regulation of dendritic spine development (GO:0060998)2.76991783
108striatum development (GO:0021756)2.76267304
109learning (GO:0007612)2.75703738
110regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.75638903
111regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.74228332
112protein heterotrimerization (GO:0070208)2.73412819
113regulation of vesicle fusion (GO:0031338)2.72631978
114G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.72450605
115presynaptic membrane organization (GO:0097090)2.72427955
116negative regulation of dendrite development (GO:2000171)2.72024041
117prepulse inhibition (GO:0060134)2.68951076
118negative regulation of catenin import into nucleus (GO:0035414)2.68787604
119regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.68708381
120* homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.68557185
121presynaptic membrane assembly (GO:0097105)2.66783718
122response to histamine (GO:0034776)2.66578645
123neuronal ion channel clustering (GO:0045161)2.66389318
124cardiac muscle hypertrophy (GO:0003300)2.61468002
125positive regulation of axon extension (GO:0045773)2.61140577
126response to epinephrine (GO:0071871)2.61092305
127cell morphogenesis involved in neuron differentiation (GO:0048667)2.57340723
128cytoskeletal anchoring at plasma membrane (GO:0007016)2.56898558
129striated muscle hypertrophy (GO:0014897)2.55874422
130cellular response to epinephrine stimulus (GO:0071872)2.55743373
131regulation of cell communication by electrical coupling (GO:0010649)2.54483804
132myofibril assembly (GO:0030239)2.54075515
133cellular response to monoamine stimulus (GO:0071868)2.53571959
134cellular response to catecholamine stimulus (GO:0071870)2.53571959
135sarcomere organization (GO:0045214)2.52796282
136regulation of cardiac muscle cell contraction (GO:0086004)2.51513562
137response to catecholamine (GO:0071869)2.51448276
138response to monoamine (GO:0071867)2.51448276
139regulation of the force of heart contraction (GO:0002026)2.51246024
140detection of calcium ion (GO:0005513)2.50821022
141regulation of glycogen (starch) synthase activity (GO:2000465)2.47181261
142cAMP biosynthetic process (GO:0006171)2.43831807
143positive regulation of osteoblast proliferation (GO:0033690)2.39336805
144cGMP-mediated signaling (GO:0019934)2.36683211
145potassium ion homeostasis (GO:0055075)2.36572343
146growth hormone secretion (GO:0030252)2.32197750
147regulation of axon extension involved in axon guidance (GO:0048841)2.31392437
148bone trabecula formation (GO:0060346)2.30800268
149cardiac muscle hypertrophy in response to stress (GO:0014898)2.26582725
150muscle hypertrophy in response to stress (GO:0003299)2.26582725
151cardiac muscle adaptation (GO:0014887)2.26582725
152endodermal cell differentiation (GO:0035987)2.26149526
153outflow tract septum morphogenesis (GO:0003148)2.25303972
154chondrocyte proliferation (GO:0035988)2.24527516
155ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.24266916
156neuron projection extension (GO:1990138)2.23334109
157actomyosin structure organization (GO:0031032)2.23123716
158relaxation of cardiac muscle (GO:0055119)2.22707065
159calcium-mediated signaling using intracellular calcium source (GO:0035584)2.22204141
160membrane assembly (GO:0071709)2.21359956
161positive regulation of vascular permeability (GO:0043117)2.20618165
162amino acid import (GO:0043090)2.19730596
163potassium ion import (GO:0010107)2.19485431
164sequestering of extracellular ligand from receptor (GO:0035581)2.19420590
165positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.18741107
166L-amino acid import (GO:0043092)2.18298843
167cAMP-mediated signaling (GO:0019933)2.18107605
168adherens junction assembly (GO:0034333)2.17812546

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.06295677
2GBX2_23144817_ChIP-Seq_PC3_Human3.44769303
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.11051697
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.97414389
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.94409126
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.73728692
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.73418401
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.73418401
9* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.59051080
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.57102874
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.54415771
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.54062771
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.43262694
14DROSHA_22980978_ChIP-Seq_HELA_Human2.42822529
15* EED_16625203_ChIP-ChIP_MESCs_Mouse2.40095014
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.37703011
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.31399207
18REST_21632747_ChIP-Seq_MESCs_Mouse2.28902541
19CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.28587508
20TRIM28_21343339_ChIP-Seq_HEK293_Human2.24545768
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.22013122
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.21239116
23RARB_27405468_Chip-Seq_BRAIN_Mouse2.20342297
24SUZ12_27294783_Chip-Seq_ESCs_Mouse2.18032218
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.06754059
26PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.97473689
27ZNF274_21170338_ChIP-Seq_K562_Hela1.96916431
28REST_18959480_ChIP-ChIP_MESCs_Mouse1.91797372
29AR_21572438_ChIP-Seq_LNCaP_Human1.85834993
30EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.83031760
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.81041659
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.73479507
33MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.70494001
34IKZF1_21737484_ChIP-ChIP_HCT116_Human1.69680873
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.66077175
36THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.62761963
37* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.59336993
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58426839
39* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.57171845
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54117892
41SMAD4_21799915_ChIP-Seq_A2780_Human1.52548269
42RING1B_27294783_Chip-Seq_ESCs_Mouse1.43531454
43RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43529506
44RARG_19884340_ChIP-ChIP_MEFs_Mouse1.40499896
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.37566767
46TAF15_26573619_Chip-Seq_HEK293_Human1.37397135
47P300_19829295_ChIP-Seq_ESCs_Human1.35996031
48SOX2_21211035_ChIP-Seq_LN229_Gbm1.35373142
49WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.35056170
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.34618220
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31896039
52ZNF217_24962896_ChIP-Seq_MCF-7_Human1.29209594
53AR_19668381_ChIP-Seq_PC3_Human1.28227543
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.27139334
55ERG_21242973_ChIP-ChIP_JURKAT_Human1.26837857
56ISL1_27105846_Chip-Seq_CPCs_Mouse1.24384079
57NR3C1_23031785_ChIP-Seq_PC12_Mouse1.24358724
58WT1_25993318_ChIP-Seq_PODOCYTE_Human1.23464288
59RING1B_27294783_Chip-Seq_NPCs_Mouse1.23238203
60STAT3_23295773_ChIP-Seq_U87_Human1.22921055
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.22889583
62* AR_25329375_ChIP-Seq_VCAP_Human1.22308191
63TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19966767
64TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19713958
65OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19689007
66ZFP281_18757296_ChIP-ChIP_E14_Mouse1.19620955
67YAP1_20516196_ChIP-Seq_MESCs_Mouse1.19506456
68ARNT_22903824_ChIP-Seq_MCF-7_Human1.15340328
69SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14913043
70TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14380515
71TBX20_22328084_ChIP-Seq_HEART_Mouse1.13339338
72TBX20_22080862_ChIP-Seq_HEART_Mouse1.13339338
73NFIB_24661679_ChIP-Seq_LUNG_Mouse1.11038243
74TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.11025895
75CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09572911
76TP53_18474530_ChIP-ChIP_U2OS_Human1.09454109
77NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09110336
78CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.08296213
79BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.07995517
80RBPJ_22232070_ChIP-Seq_NCS_Mouse1.07990741
81EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.07690141
82KDM2B_26808549_Chip-Seq_K562_Human1.07434084
83ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.07249755
84CJUN_26792858_Chip-Seq_BT549_Human1.07062290
85VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.06534203
86ESR2_21235772_ChIP-Seq_MCF-7_Human1.06395130
87RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.06083882
88AHR_22903824_ChIP-Seq_MCF-7_Human1.05188531
89TP53_16413492_ChIP-PET_HCT116_Human1.04632795
90AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04336668
91TCF4_23295773_ChIP-Seq_U87_Human1.04140133
92MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03503497
93CTNNB1_20460455_ChIP-Seq_HCT116_Human1.02684067
94SMAD_19615063_ChIP-ChIP_OVARY_Human1.02297135
95EP300_21415370_ChIP-Seq_HL-1_Mouse1.02236930
96HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.01801708
97IGF1R_20145208_ChIP-Seq_DFB_Human1.01522702
98* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.01102869
99RNF2_27304074_Chip-Seq_NSC_Mouse1.00597135
100TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00459066
101WT1_19549856_ChIP-ChIP_CCG9911_Human1.00159441
102STAT6_21828071_ChIP-Seq_BEAS2B_Human1.00055049
103BMI1_23680149_ChIP-Seq_NPCS_Mouse0.99779374
104P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99458855
105DNAJC2_21179169_ChIP-ChIP_NT2_Human0.98452789
106SMAD3_21741376_ChIP-Seq_ESCs_Human0.97950058
107OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.97929462
108EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.97876127
109SMAD4_21741376_ChIP-Seq_HESCs_Human0.97662862
110POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97605807
111TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97605807
112TP53_20018659_ChIP-ChIP_R1E_Mouse0.97408848
113RUNX2_22187159_ChIP-Seq_PCA_Human0.97180936
114SMAD3_21741376_ChIP-Seq_HESCs_Human0.96407037
115* TP53_23651856_ChIP-Seq_MEFs_Mouse0.95907611
116TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95823608
117DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.94902203
118NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.94411681
119FUS_26573619_Chip-Seq_HEK293_Human0.93677505
120CTCF_27219007_Chip-Seq_Bcells_Human0.93138042
121ZFP281_27345836_Chip-Seq_ESCs_Mouse0.92758701
122TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91507891
123RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.91047526
124LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90505349
125NRF2_20460467_ChIP-Seq_MEFs_Mouse0.90149714
126NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.90149714
127MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.90101251
128SOX9_26525672_Chip-Seq_HEART_Mouse0.88178106
129CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.87102660

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.05845958
2MP0008438_abnormal_cutaneous_collagen5.05068143
3MP0003880_abnormal_central_pattern3.89621026
4MP0003635_abnormal_synaptic_transmissio3.85769097
5MP0004270_analgesia3.69573894
6MP0002063_abnormal_learning/memory/cond3.13579175
7MP0005275_abnormal_skin_tensile3.07171536
8MP0009745_abnormal_behavioral_response2.97718229
9MP0002064_seizures2.71808366
10MP0004272_abnormal_basement_membrane2.57793404
11MP0002572_abnormal_emotion/affect_behav2.51895375
12MP0005423_abnormal_somatic_nervous2.51350607
13MP0009046_muscle_twitch2.50727287
14MP0001958_emphysema2.50190780
15MP0001486_abnormal_startle_reflex2.45716848
16MP0002734_abnormal_mechanical_nocicepti2.44901551
17MP0003705_abnormal_hypodermis_morpholog2.37969486
18MP0000778_abnormal_nervous_system2.35933611
19MP0001968_abnormal_touch/_nociception2.32593703
20MP0003279_aneurysm2.30222919
21MP0004084_abnormal_cardiac_muscle2.29718625
22MP0005257_abnormal_intraocular_pressure2.29109941
23MP0009780_abnormal_chondrocyte_physiolo2.20326822
24MP0002272_abnormal_nervous_system2.12445216
25MP0002735_abnormal_chemical_nociception2.10119962
26MP0005171_absent_coat_pigmentation2.04914548
27MP0002184_abnormal_innervation2.00630736
28MP0000569_abnormal_digit_pigmentation2.00440304
29MP0010368_abnormal_lymphatic_system2.00172348
30MP0001440_abnormal_grooming_behavior1.95788707
31MP0003122_maternal_imprinting1.95628441
32MP0002638_abnormal_pupillary_reflex1.90854888
33MP0004858_abnormal_nervous_system1.90484828
34MP0003879_abnormal_hair_cell1.81593847
35MP0002822_catalepsy1.77753711
36MP0002067_abnormal_sensory_capabilities1.77147517
37MP0002733_abnormal_thermal_nociception1.77031651
38MP0002909_abnormal_adrenal_gland1.76555028
39MP0004811_abnormal_neuron_physiology1.75011834
40MP0002736_abnormal_nociception_after1.70424794
41MP0002557_abnormal_social/conspecific_i1.69478449
42MP0001970_abnormal_pain_threshold1.67100451
43MP0003646_muscle_fatigue1.66725264
44MP0005670_abnormal_white_adipose1.66007623
45MP0008569_lethality_at_weaning1.65372478
46MP0006138_congestive_heart_failure1.64309379
47MP0000955_abnormal_spinal_cord1.61817217
48MP0004036_abnormal_muscle_relaxation1.60593430
49MP0002882_abnormal_neuron_morphology1.54283188
50MP0003329_amyloid_beta_deposits1.52306391
51MP0004924_abnormal_behavior1.51320212
52MP0005386_behavior/neurological_phenoty1.51320212
53MP0006276_abnormal_autonomic_nervous1.50916622
54MP0002295_abnormal_pulmonary_circulatio1.48506880
55MP0001501_abnormal_sleep_pattern1.45766071
56MP0004885_abnormal_endolymph1.40166257
57MP0005409_darkened_coat_color1.37631248
58MP0000749_muscle_degeneration1.37450178
59MP0001984_abnormal_olfaction1.32570131
60MP0002066_abnormal_motor_capabilities/c1.32161003
61MP0001661_extended_life_span1.31658996
62MP0003787_abnormal_imprinting1.31589629
63MP0005646_abnormal_pituitary_gland1.30784998
64MP0005551_abnormal_eye_electrophysiolog1.28220952
65MP0000751_myopathy1.26624024
66MP0002152_abnormal_brain_morphology1.26031272
67MP0000462_abnormal_digestive_system1.24695048
68MP0004145_abnormal_muscle_electrophysio1.20624195
69MP0001502_abnormal_circadian_rhythm1.20497261
70MP0001299_abnormal_eye_distance/1.19988672
71MP0002972_abnormal_cardiac_muscle1.19233221
72MP0004510_myositis1.18197769
73MP0001879_abnormal_lymphatic_vessel1.17728885
74MP0001529_abnormal_vocalization1.16958479
75MP0005623_abnormal_meninges_morphology1.16092610
76MP0004087_abnormal_muscle_fiber1.15778482
77MP0003633_abnormal_nervous_system1.14624921
78MP0004233_abnormal_muscle_weight1.12369204
79MP0003690_abnormal_glial_cell1.11573955
80MP0000759_abnormal_skeletal_muscle1.11035085
81MP0004130_abnormal_muscle_cell1.10725295
82MP0005330_cardiomyopathy1.09982848
83MP0003137_abnormal_impulse_conducting1.09818249
84MP0000750_abnormal_muscle_regeneration1.08225396
85MP0001188_hyperpigmentation1.05265765
86MP0002127_abnormal_cardiovascular_syste1.02642481
87MP0004085_abnormal_heartbeat1.02408178
88MP0005369_muscle_phenotype1.01641308
89MP0000631_abnormal_neuroendocrine_gland1.01581347
90MP0003283_abnormal_digestive_organ1.00509361
91MP0001177_atelectasis1.00425011
92MP0000747_muscle_weakness1.00409423
93MP0002269_muscular_atrophy0.99640483
94MP0005253_abnormal_eye_physiology0.98973267
95MP0003631_nervous_system_phenotype0.98343436
96MP0005503_abnormal_tendon_morphology0.97028850
97MP0002106_abnormal_muscle_physiology0.96737329
98MP0000920_abnormal_myelination0.96638158
99MP0005187_abnormal_penis_morphology0.95867860
100MP0003634_abnormal_glial_cell0.95606024
101MP0009384_cardiac_valve_regurgitation0.95531888
102MP0009250_abnormal_appendicular_skeleto0.95126122
103MP0005508_abnormal_skeleton_morphology0.94655858
104MP0003950_abnormal_plasma_membrane0.93652305
105MP0000767_abnormal_smooth_muscle0.93387547
106MP0002752_abnormal_somatic_nervous0.92404467
107MP0002896_abnormal_bone_mineralization0.91570831
108MP0000534_abnormal_ureter_morphology0.91515615
109MP0004134_abnormal_chest_morphology0.90794335
110MP0005595_abnormal_vascular_smooth0.90666720
111MP0003861_abnormal_nervous_system0.90619670
112MP0002229_neurodegeneration0.89086293
113MP0003385_abnormal_body_wall0.88200082
114MP0000733_abnormal_muscle_development0.87414821
115MP0002060_abnormal_skin_morphology0.87386235
116MP0002069_abnormal_eating/drinking_beha0.87127045
117MP0001485_abnormal_pinna_reflex0.85209647
118MP0000013_abnormal_adipose_tissue0.84825638
119MP0008961_abnormal_basal_metabolism0.84651712
120MP0003091_abnormal_cell_migration0.83121317
121MP0000428_abnormal_craniofacial_morphol0.82455189
122MP0002090_abnormal_vision0.82002561
123MP0002089_abnormal_postnatal_growth/wei0.80988717
124MP0005394_taste/olfaction_phenotype0.80229132
125MP0005499_abnormal_olfactory_system0.80229132
126MP0004484_altered_response_of0.80167316
127MP0002249_abnormal_larynx_morphology0.79950629
128MP0005645_abnormal_hypothalamus_physiol0.78953023
129MP0001544_abnormal_cardiovascular_syste0.78101522
130MP0005385_cardiovascular_system_phenoty0.78101522
131MP0003121_genomic_imprinting0.77595381
132MP0004215_abnormal_myocardial_fiber0.77549139
133MP0003136_yellow_coat_color0.76804118
134MP0010386_abnormal_urinary_bladder0.76732105
135MP0003632_abnormal_nervous_system0.75876664
136MP0004142_abnormal_muscle_tone0.75782386
137MP0002837_dystrophic_cardiac_calcinosis0.75513522
138MP0001963_abnormal_hearing_physiology0.73974463
139MP0001905_abnormal_dopamine_level0.73248514
140MP0004742_abnormal_vestibular_system0.70761581
141MP0003942_abnormal_urinary_system0.69735101
142MP0006072_abnormal_retinal_apoptosis0.67948869
143MP0001943_abnormal_respiration0.65005857
144MP0008874_decreased_physiological_sensi0.64884316
145MP0003045_fibrosis0.64884001
146MP0002653_abnormal_ependyma_morphology0.61591796
147MP0005248_abnormal_Harderian_gland0.61510658
148MP0010769_abnormal_survival0.60212656
149MP0002108_abnormal_muscle_morphology0.59616533
150MP0002081_perinatal_lethality0.59542300
151MP0005620_abnormal_muscle_contractility0.59254035
152MP0002082_postnatal_lethality0.59198719
153MP0010770_preweaning_lethality0.59198719

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.22139917
2Visual hallucinations (HP:0002367)5.70685712
3Focal seizures (HP:0007359)5.53057677
4Premature rupture of membranes (HP:0001788)5.27799655
5Myokymia (HP:0002411)5.00420292
6Protrusio acetabuli (HP:0003179)4.74514949
7Absence seizures (HP:0002121)4.57577289
8Epileptic encephalopathy (HP:0200134)3.97857751
9Dialeptic seizures (HP:0011146)3.88281361
10Bundle branch block (HP:0011710)3.56036145
11Action tremor (HP:0002345)3.50314986
12Abnormality of dentin (HP:0010299)3.46328584
13Aortic dissection (HP:0002647)3.45483111
14Vascular tortuosity (HP:0004948)3.42331087
15Atonic seizures (HP:0010819)3.39221313
16Febrile seizures (HP:0002373)3.37352536
17Type 1 muscle fiber predominance (HP:0003803)3.33878784
18Aortic aneurysm (HP:0004942)3.31879972
19Sudden death (HP:0001699)3.31777373
20Progressive cerebellar ataxia (HP:0002073)3.27555816
21Neonatal short-limb short stature (HP:0008921)3.20508123
22Bladder diverticulum (HP:0000015)3.19860820
23Arterial tortuosity (HP:0005116)3.13066333
24Generalized tonic-clonic seizures (HP:0002069)3.09444298
25Increased variability in muscle fiber diameter (HP:0003557)2.97984933
26Hyporeflexia of lower limbs (HP:0002600)2.97262905
27Soft skin (HP:0000977)2.96754105
28Supranuclear gaze palsy (HP:0000605)2.90936357
29Atrial fibrillation (HP:0005110)2.89888014
30Broad-based gait (HP:0002136)2.84836488
31Muscle fiber splitting (HP:0003555)2.78482694
32Distal lower limb muscle weakness (HP:0009053)2.78452685
33Excessive salivation (HP:0003781)2.78177629
34Drooling (HP:0002307)2.78177629
35Impaired vibration sensation in the lower limbs (HP:0002166)2.77928378
36Spinal rigidity (HP:0003306)2.77806727
37Poor eye contact (HP:0000817)2.76548354
38Broad metatarsal (HP:0001783)2.70800181
39Genetic anticipation (HP:0003743)2.70719673
40Depression (HP:0000716)2.68880167
41Urinary bladder sphincter dysfunction (HP:0002839)2.68584999
42Atrophic scars (HP:0001075)2.66345332
43Primary atrial arrhythmia (HP:0001692)2.66199342
44Ankle clonus (HP:0011448)2.65815558
45Mutism (HP:0002300)2.61704870
46Supraventricular tachycardia (HP:0004755)2.60800093
47Truncal ataxia (HP:0002078)2.59411748
48Supraventricular arrhythmia (HP:0005115)2.58974416
49Dysdiadochokinesis (HP:0002075)2.56650816
50Abnormal social behavior (HP:0012433)2.55672159
51Impaired social interactions (HP:0000735)2.55672159
52Gaze-evoked nystagmus (HP:0000640)2.53704994
53Turricephaly (HP:0000262)2.45998676
54Syncope (HP:0001279)2.44403103
55Ventricular tachycardia (HP:0004756)2.43173681
56Abnormality of skeletal muscle fiber size (HP:0012084)2.40992321
57Abnormal atrioventricular conduction (HP:0005150)2.40979187
58Fragile skin (HP:0001030)2.39884353
59Heart block (HP:0012722)2.39737087
60Natal tooth (HP:0000695)2.39340968
61Epileptiform EEG discharges (HP:0011182)2.38594348
62Peritonitis (HP:0002586)2.38546259
63Abnormality of the lower motor neuron (HP:0002366)2.38330464
64Bowel diverticulosis (HP:0005222)2.38283133
65Hyperventilation (HP:0002883)2.38103613
66Neoplasm of the heart (HP:0100544)2.37988787
67Torticollis (HP:0000473)2.37591017
68Genu recurvatum (HP:0002816)2.33431357
69Megalencephaly (HP:0001355)2.33182740
70Abnormality of the calf musculature (HP:0001430)2.32528084
71Abnormal eating behavior (HP:0100738)2.32296712
72EEG with generalized epileptiform discharges (HP:0011198)2.31098125
73Wormian bones (HP:0002645)2.25859025
74Impaired smooth pursuit (HP:0007772)2.25243403
75Dysmetria (HP:0001310)2.24407032
76Urinary urgency (HP:0000012)2.24318467
77Asymmetric septal hypertrophy (HP:0001670)2.22818543
78Atrioventricular block (HP:0001678)2.22766242
79Follicular hyperkeratosis (HP:0007502)2.22303590
80Hemiparesis (HP:0001269)2.22184637
81Insidious onset (HP:0003587)2.21607969
82Termporal pattern (HP:0011008)2.21607969
83Increased connective tissue (HP:0009025)2.21583427
84Pulmonary artery stenosis (HP:0004415)2.21484262
85Cerebral aneurysm (HP:0004944)2.21356509
86Hypsarrhythmia (HP:0002521)2.20861929
87Amblyopia (HP:0000646)2.19093550
88Neurofibrillary tangles (HP:0002185)2.17498603
89Mitral valve prolapse (HP:0001634)2.16681567
90Papilledema (HP:0001085)2.16570156
91Persistence of primary teeth (HP:0006335)2.16391169
92Mildly elevated creatine phosphokinase (HP:0008180)2.16159748
93Postural instability (HP:0002172)2.15593669
94Cerebral inclusion bodies (HP:0100314)2.15509297
95Round ear (HP:0100830)2.15212905
96Ankle contracture (HP:0006466)2.15120806
97Wide anterior fontanel (HP:0000260)2.14487423
98Abnormality of the corticospinal tract (HP:0002492)2.14035558
99Mitral regurgitation (HP:0001653)2.12872196
100Spastic gait (HP:0002064)2.12632805
101Amyotrophic lateral sclerosis (HP:0007354)2.12229171
102Focal dystonia (HP:0004373)2.10336236
103Anxiety (HP:0000739)2.08704638
104Absent speech (HP:0001344)2.07687061
105Intention tremor (HP:0002080)2.07391557
106Infantile muscular hypotonia (HP:0008947)2.06764473
107Dilatation of the ascending aorta (HP:0005111)2.05561267
108Lipoatrophy (HP:0100578)2.04258931
109Hemiplegia (HP:0002301)2.03180306
110Abnormality of ocular smooth pursuit (HP:0000617)2.01195007
111Stereotypic behavior (HP:0000733)1.99551734
112Pheochromocytoma (HP:0002666)1.98947296
113Hepatoblastoma (HP:0002884)1.98066240
114Rapidly progressive (HP:0003678)1.96954150
115Difficulty running (HP:0009046)1.95158964
116Hypoplasia of the iris (HP:0007676)1.94933749
117Polyphagia (HP:0002591)1.94690875
118Lower limb muscle weakness (HP:0007340)1.92825066
119Hypoplasia of the brainstem (HP:0002365)1.91963260
120Aplasia/Hypoplasia of the brainstem (HP:0007362)1.91963260
121Fetal akinesia sequence (HP:0001989)1.91793817
122Hypoventilation (HP:0002791)1.91326651
123Agitation (HP:0000713)1.90948426
124Abnormality of the 4th metacarpal (HP:0010012)1.90514784
125Pointed chin (HP:0000307)1.89710791
126Right ventricular cardiomyopathy (HP:0011663)1.88758760
127Wrist flexion contracture (HP:0001239)1.88578186
128Scanning speech (HP:0002168)1.87722233
129Aqueductal stenosis (HP:0002410)1.87668822
130Central scotoma (HP:0000603)1.87453661
131Craniofacial dystonia (HP:0012179)1.86662432
132Dysmetric saccades (HP:0000641)1.86086769
133Slender build (HP:0001533)1.86052853
134Bronchomalacia (HP:0002780)1.85728520
135Diplopia (HP:0000651)1.85372254
136Abnormality of binocular vision (HP:0011514)1.85372254
137Generalized myoclonic seizures (HP:0002123)1.85371592
138Aortic regurgitation (HP:0001659)1.85189989
139Mild short stature (HP:0003502)1.84645436
140Abnormality of the ischium (HP:0003174)1.84637910
141Disproportionate tall stature (HP:0001519)1.84610966
142Aneurysm (HP:0002617)1.83760329
143Advanced eruption of teeth (HP:0006288)1.83265923
144Broad ribs (HP:0000885)1.83129406
145Venous insufficiency (HP:0005293)1.83044173
146Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.82390907
147Short 4th metacarpal (HP:0010044)1.82390907
148Joint laxity (HP:0001388)1.80465421
149Distal lower limb amyotrophy (HP:0008944)1.80382758
150Ventricular arrhythmia (HP:0004308)1.79482725
151Coronal craniosynostosis (HP:0004440)1.79378635
152Glucose intolerance (HP:0000833)1.78894453
153Venous abnormality (HP:0002624)1.78818293
154Lower limb amyotrophy (HP:0007210)1.78583626
155Shallow orbits (HP:0000586)1.78534453
156Hyperextensible skin (HP:0000974)1.78129467
157Limb dystonia (HP:0002451)1.77030760
158Hyperacusis (HP:0010780)1.75828074
159Biconcave vertebral bodies (HP:0004586)1.75225435
160Ulnar bowing (HP:0003031)1.74360563
161Congenital stationary night blindness (HP:0007642)1.73635282
162Impaired vibratory sensation (HP:0002495)1.72451335
163EMG: neuropathic changes (HP:0003445)1.72068622
164Megalocornea (HP:0000485)1.71876010
165Exotropia (HP:0000577)1.71722042
166Abnormality of salivation (HP:0100755)1.71687633
167Insomnia (HP:0100785)1.70980377
168Mitral stenosis (HP:0001718)1.70092837
169Abnormality of the astrocytes (HP:0100707)1.68872826
170Astrocytoma (HP:0009592)1.68872826
171Ectopia lentis (HP:0001083)1.68719627
172Akinesia (HP:0002304)1.67836055
173Macroorchidism (HP:0000053)1.67733794
174Chin dimple (HP:0010751)1.67699565
175Progressive inability to walk (HP:0002505)1.66883957
176Bradykinesia (HP:0002067)1.65869395
177Prolonged QT interval (HP:0001657)1.65484505
178Open mouth (HP:0000194)1.65284264
179Abnormal delivery (HP:0001787)1.65225870
180Neuroendocrine neoplasm (HP:0100634)1.63559622
181Incomplete penetrance (HP:0003829)1.62694998
182Obstructive sleep apnea (HP:0002870)1.61122544
183Abnormality of pain sensation (HP:0010832)1.58999031
184Impaired pain sensation (HP:0007328)1.58999031
185Overgrowth (HP:0001548)1.58434614
186Neuronal loss in central nervous system (HP:0002529)1.58162540
187Specific learning disability (HP:0001328)1.58052719

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK24.95614581
2MARK14.53211029
3NTRK33.68129547
4EPHA43.50017489
5MYLK3.17188248
6MAP3K92.84598427
7MINK12.78023068
8MAP3K42.63967511
9TTN2.55878878
10GRK12.46642396
11NTRK22.44862351
12PRKD32.13427955
13PAK62.12102605
14TRIB32.05138440
15MAP2K72.02340926
16KSR11.97158677
17DAPK21.91399804
18MAP3K121.85711837
19BLK1.83100444
20MAP2K41.79521452
21CASK1.79317641
22CAMKK11.65032396
23LATS21.63386955
24NTRK11.58937158
25KSR21.56880912
26TYRO31.52359117
27MAPK131.48642236
28PNCK1.47317609
29CDK51.47310620
30PHKG11.44287297
31PHKG21.44287297
32PRPF4B1.43442052
33SIK31.35088264
34WNK11.32463214
35RIPK11.32139812
36SIK21.31575470
37CAMK1G1.28223222
38TNIK1.26356781
39NEK91.23699855
40PAK31.20021172
41TESK11.19999319
42FGFR21.18523604
43PLK21.16306747
44STK381.14133836
45CDK181.13216796
46MAP3K71.11253912
47PRKCG1.09037134
48CDK151.06557128
49CAMKK21.02994450
50UHMK11.02668716
51CDK141.02653767
52DAPK11.02061554
53PAK20.99027858
54TAOK10.98463681
55PRKD10.97985645
56RET0.95419912
57MARK20.93905865
58PDGFRA0.93291706
59CDK11A0.92120712
60ERBB30.90510631
61MAPK70.90017858
62FER0.87266836
63PRKCH0.86950690
64CAMK2A0.84044630
65PDGFRB0.83305467
66SGK4940.80975887
67SGK2230.80975887
68MAP3K20.80547688
69FES0.80376437
70GRK50.79923209
71CAMK10.78933504
72DYRK1A0.78772229
73BCR0.77861509
74DYRK20.77402518
75LMTK20.76754952
76TRPM70.75656994
77STK110.74727744
78PIK3CA0.74714755
79OBSCN0.74670633
80DMPK0.74299140
81CAMK2G0.74289373
82PRKAA10.72191663
83CSNK1G20.71063220
84SGK20.69642163
85DDR20.69051294
86GRK70.66909854
87PTK2B0.66609742
88RPS6KA20.65461526
89PRKD20.65194475
90TGFBR20.65012579
91MAP3K60.64910629
92SGK10.63925559
93MOS0.62961688
94CAMK2B0.62073634
95CDC42BPA0.60440368
96PRKCE0.60127596
97CDK190.60067896
98SGK30.59524447
99PRKG20.58192955
100PRKCZ0.57777717
101EPHB20.57730972
102ALK0.57626086
103NEK10.56123708
104RPS6KA30.54115784
105MAPK100.53263127
106MTOR0.52741085
107ABL20.51883146
108FYN0.51795584
109AKT20.50454150
110MAP2K10.49589466
111RIPK40.48938560
112ROCK10.48934030
113MAPK40.48367219
114PKN20.47775090
115AKT30.47265745
116PKN10.46114750
117PDPK10.45723081
118CAMK40.45471149
119MAPK150.43812567
120ERBB20.43143287
121ADRBK10.42576290
122PRKG10.42493113
123SCYL20.41843187
124ROCK20.41765129
125FGFR10.40753929
126LIMK10.40509022
127GSK3A0.40263466
128CAMK1D0.39415672
129ICK0.39257149
130PRKACG0.37811242
131PTK20.37746107
132WNK30.37682559
133CAMK2D0.37188561
134SIK10.36952694
135MAPK120.35502563
136NEK60.35208384

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.36282594
2Synaptic vesicle cycle_Homo sapiens_hsa047212.78175216
3Circadian entrainment_Homo sapiens_hsa047132.55015208
4GABAergic synapse_Homo sapiens_hsa047272.46170766
5Glutamatergic synapse_Homo sapiens_hsa047242.40828382
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.38455491
7Long-term potentiation_Homo sapiens_hsa047202.34842647
8ECM-receptor interaction_Homo sapiens_hsa045122.33510901
9Olfactory transduction_Homo sapiens_hsa047402.30182011
10Morphine addiction_Homo sapiens_hsa050322.26899184
11Amphetamine addiction_Homo sapiens_hsa050312.15778932
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.13281324
13Dopaminergic synapse_Homo sapiens_hsa047282.07798301
14Insulin secretion_Homo sapiens_hsa049112.04062951
15Cholinergic synapse_Homo sapiens_hsa047251.90120881
16Salivary secretion_Homo sapiens_hsa049701.89560875
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.78619513
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.77026276
19Axon guidance_Homo sapiens_hsa043601.71205614
20Cocaine addiction_Homo sapiens_hsa050301.69715582
21Gastric acid secretion_Homo sapiens_hsa049711.63977244
22Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.63972720
23Oxytocin signaling pathway_Homo sapiens_hsa049211.60673165
24Renin secretion_Homo sapiens_hsa049241.55914261
25Long-term depression_Homo sapiens_hsa047301.51473051
26Taste transduction_Homo sapiens_hsa047421.46006025
27Calcium signaling pathway_Homo sapiens_hsa040201.43102146
28Gap junction_Homo sapiens_hsa045401.42347257
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.42303563
30Serotonergic synapse_Homo sapiens_hsa047261.39629967
31GnRH signaling pathway_Homo sapiens_hsa049121.37028306
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.33955609
33Protein digestion and absorption_Homo sapiens_hsa049741.30644775
34Type II diabetes mellitus_Homo sapiens_hsa049301.29869381
35Glioma_Homo sapiens_hsa052141.26212766
36cAMP signaling pathway_Homo sapiens_hsa040241.23859355
37Estrogen signaling pathway_Homo sapiens_hsa049151.22594765
38Phototransduction_Homo sapiens_hsa047441.20098101
39Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.19788189
40Dilated cardiomyopathy_Homo sapiens_hsa054141.15474318
41ErbB signaling pathway_Homo sapiens_hsa040121.13674782
42Melanogenesis_Homo sapiens_hsa049161.13439462
43cGMP-PKG signaling pathway_Homo sapiens_hsa040221.12385822
44Amoebiasis_Homo sapiens_hsa051461.08331905
45Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.99877221
46Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.99328098
47Phosphatidylinositol signaling system_Homo sapiens_hsa040700.96922571
48Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.96419577
49Cardiac muscle contraction_Homo sapiens_hsa042600.94151637
50Vascular smooth muscle contraction_Homo sapiens_hsa042700.92024845
51Endometrial cancer_Homo sapiens_hsa052130.90865829
52Collecting duct acid secretion_Homo sapiens_hsa049660.87236247
53Oocyte meiosis_Homo sapiens_hsa041140.85086462
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.84485799
55Thyroid hormone signaling pathway_Homo sapiens_hsa049190.84056927
56AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.83575432
57Phospholipase D signaling pathway_Homo sapiens_hsa040720.83512046
58Ovarian steroidogenesis_Homo sapiens_hsa049130.82711164
59Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.82409217
60Thyroid hormone synthesis_Homo sapiens_hsa049180.81784813
61PPAR signaling pathway_Homo sapiens_hsa033200.80325153
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.79372314
63Regulation of actin cytoskeleton_Homo sapiens_hsa048100.78553977
64mTOR signaling pathway_Homo sapiens_hsa041500.78201439
65Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.77513920
66MAPK signaling pathway_Homo sapiens_hsa040100.77346336
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.77147357
68Dorso-ventral axis formation_Homo sapiens_hsa043200.76166045
69Wnt signaling pathway_Homo sapiens_hsa043100.75487732
70Pancreatic secretion_Homo sapiens_hsa049720.75474543
71Choline metabolism in cancer_Homo sapiens_hsa052310.74667164
72Colorectal cancer_Homo sapiens_hsa052100.74336755
73Adherens junction_Homo sapiens_hsa045200.72437322
74Vibrio cholerae infection_Homo sapiens_hsa051100.72373760
75PI3K-Akt signaling pathway_Homo sapiens_hsa041510.70427482
76VEGF signaling pathway_Homo sapiens_hsa043700.70400563
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.70164367
78Rap1 signaling pathway_Homo sapiens_hsa040150.67559533
79Nitrogen metabolism_Homo sapiens_hsa009100.67386286
80ABC transporters_Homo sapiens_hsa020100.66313575
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66289585
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.65851537
83Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.64187893
84Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.64007948
85Ras signaling pathway_Homo sapiens_hsa040140.63364027
86Platelet activation_Homo sapiens_hsa046110.63094588
87Glucagon signaling pathway_Homo sapiens_hsa049220.63026282
88Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62694800
89Hedgehog signaling pathway_Homo sapiens_hsa043400.61880522
90Notch signaling pathway_Homo sapiens_hsa043300.61450049
91Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60226018
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60218676
93Alcoholism_Homo sapiens_hsa050340.60052635
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58386547
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57755536
96Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57573846
97Basal cell carcinoma_Homo sapiens_hsa052170.56707803
98Hippo signaling pathway_Homo sapiens_hsa043900.55993751
99Renal cell carcinoma_Homo sapiens_hsa052110.55902271
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.54982798
101Non-small cell lung cancer_Homo sapiens_hsa052230.54902762
102Small cell lung cancer_Homo sapiens_hsa052220.53674486
103Pathways in cancer_Homo sapiens_hsa052000.53113650
104Circadian rhythm_Homo sapiens_hsa047100.51828751
105Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51786321
106Insulin signaling pathway_Homo sapiens_hsa049100.51109062
107Prion diseases_Homo sapiens_hsa050200.49736639
108Chronic myeloid leukemia_Homo sapiens_hsa052200.48468188
109Endocytosis_Homo sapiens_hsa041440.47819160
110Fatty acid biosynthesis_Homo sapiens_hsa000610.45886031
111MicroRNAs in cancer_Homo sapiens_hsa052060.45875377
112Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45499241
113Bile secretion_Homo sapiens_hsa049760.41883428
114Focal adhesion_Homo sapiens_hsa045100.41019496
115Proteoglycans in cancer_Homo sapiens_hsa052050.39520931
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39087732
117Inositol phosphate metabolism_Homo sapiens_hsa005620.38930218
118Central carbon metabolism in cancer_Homo sapiens_hsa052300.37573083
119Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.36870979
120Tight junction_Homo sapiens_hsa045300.35422757
121Melanoma_Homo sapiens_hsa052180.35386960
122AMPK signaling pathway_Homo sapiens_hsa041520.35181064
123Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.34657402

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