PCDHB9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to synapse (GO:0035418)6.07876232
2vocalization behavior (GO:0071625)5.78786785
3neuron cell-cell adhesion (GO:0007158)5.60335939
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.48731591
5synaptic vesicle exocytosis (GO:0016079)5.46006197
6neurotransmitter-gated ion channel clustering (GO:0072578)5.33011953
7positive regulation of synapse maturation (GO:0090129)5.21742028
8behavioral response to nicotine (GO:0035095)5.18630318
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.17331818
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.15169229
11gamma-aminobutyric acid signaling pathway (GO:0007214)5.04804944
12pyrimidine nucleobase catabolic process (GO:0006208)4.74340363
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.73223748
14regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.55079610
15regulation of synaptic vesicle exocytosis (GO:2000300)4.49578921
16regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.48880350
17glutamate secretion (GO:0014047)4.40229386
18regulation of glutamate receptor signaling pathway (GO:1900449)4.39221945
19regulation of synapse maturation (GO:0090128)4.36535188
20ionotropic glutamate receptor signaling pathway (GO:0035235)4.30368389
21presynaptic membrane assembly (GO:0097105)4.29790028
22L-fucose catabolic process (GO:0042355)4.27668107
23fucose catabolic process (GO:0019317)4.27668107
24L-fucose metabolic process (GO:0042354)4.27668107
25cellular potassium ion homeostasis (GO:0030007)4.25708379
26synaptic vesicle docking involved in exocytosis (GO:0016081)4.23456269
27retinal rod cell development (GO:0046548)4.16971595
28glutamate receptor signaling pathway (GO:0007215)4.16612553
29neuron-neuron synaptic transmission (GO:0007270)4.15008251
30synaptic vesicle maturation (GO:0016188)4.14699297
31response to pheromone (GO:0019236)4.10958324
32synaptic transmission, glutamatergic (GO:0035249)4.09696465
33postsynaptic membrane organization (GO:0001941)4.08097051
34G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.07976630
35nucleobase catabolic process (GO:0046113)3.89281840
36regulation of synaptic vesicle transport (GO:1902803)3.87761696
37presynaptic membrane organization (GO:0097090)3.85831311
38regulation of synapse structural plasticity (GO:0051823)3.78914326
39neuron recognition (GO:0008038)3.78149145
40synaptic vesicle endocytosis (GO:0048488)3.77785402
41regulation of synaptic transmission, glutamatergic (GO:0051966)3.76634202
42neurotransmitter secretion (GO:0007269)3.75795804
43locomotory exploration behavior (GO:0035641)3.75779051
44regulation of excitatory postsynaptic membrane potential (GO:0060079)3.71544728
45regulation of postsynaptic membrane potential (GO:0060078)3.68760061
46positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.67829556
47axonal fasciculation (GO:0007413)3.64486913
48layer formation in cerebral cortex (GO:0021819)3.64079989
49exploration behavior (GO:0035640)3.63799200
50long-term synaptic potentiation (GO:0060291)3.62677592
51striatum development (GO:0021756)3.51666154
52negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.50355620
53transmission of nerve impulse (GO:0019226)3.50306825
54cerebellar granule cell differentiation (GO:0021707)3.47415720
55positive regulation of membrane potential (GO:0045838)3.43072327
56nonmotile primary cilium assembly (GO:0035058)3.42296002
57mating behavior (GO:0007617)3.41456084
58regulation of neuronal synaptic plasticity (GO:0048168)3.40780437
59membrane hyperpolarization (GO:0060081)3.40412639
60positive regulation of dendritic spine morphogenesis (GO:0061003)3.39379260
61protein polyglutamylation (GO:0018095)3.38139139
62regulation of long-term neuronal synaptic plasticity (GO:0048169)3.35748648
63positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.34618629
64gamma-aminobutyric acid transport (GO:0015812)3.34375737
65innervation (GO:0060384)3.29983150
66regulation of vesicle fusion (GO:0031338)3.27273087
67* synapse assembly (GO:0007416)3.25644617
68behavioral fear response (GO:0001662)3.24500736
69behavioral defense response (GO:0002209)3.24500736
70response to histamine (GO:0034776)3.23062812
71membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.22070417
72retinal ganglion cell axon guidance (GO:0031290)3.21974314
73detection of light stimulus involved in visual perception (GO:0050908)3.21881270
74detection of light stimulus involved in sensory perception (GO:0050962)3.21881270
75regulation of synaptic plasticity (GO:0048167)3.21028953
76dendrite morphogenesis (GO:0048813)3.21012504
77neurotransmitter transport (GO:0006836)3.19943165
78long term synaptic depression (GO:0060292)3.17849142
79regulation of neurotransmitter secretion (GO:0046928)3.14975330
80fear response (GO:0042596)3.14158369
81response to auditory stimulus (GO:0010996)3.13810098
82negative regulation of synaptic transmission, GABAergic (GO:0032229)3.12327418
83potassium ion homeostasis (GO:0055075)3.09728788
84learning (GO:0007612)3.08973113
85auditory behavior (GO:0031223)3.08674211
86membrane depolarization (GO:0051899)3.05587732
87photoreceptor cell development (GO:0042461)3.04135764
88protein-cofactor linkage (GO:0018065)3.03050281
89neuronal action potential propagation (GO:0019227)3.03031886
90mitochondrial respiratory chain complex I assembly (GO:0032981)3.02297641
91NADH dehydrogenase complex assembly (GO:0010257)3.02297641
92mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.02297641
93membrane depolarization during action potential (GO:0086010)3.02294732
94* calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.00942875
95long-term memory (GO:0007616)3.00782833
96detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.00372465
97negative regulation of telomere maintenance (GO:0032205)2.99706726
98regulation of voltage-gated calcium channel activity (GO:1901385)2.99701108
99mechanosensory behavior (GO:0007638)2.99684994
100* synaptic transmission (GO:0007268)2.99010928
101protein localization to cilium (GO:0061512)2.98738987
102cerebellar Purkinje cell differentiation (GO:0021702)2.98558289
103regulation of dendritic spine morphogenesis (GO:0061001)2.97430579
104startle response (GO:0001964)2.97354616
105hindbrain development (GO:0030902)2.97304277
106positive regulation of synaptic transmission (GO:0050806)2.92841422
107negative regulation of oligodendrocyte differentiation (GO:0048715)2.92768504
108dendrite development (GO:0016358)2.91905930
109positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.91022484
110intraspecies interaction between organisms (GO:0051703)2.90915585
111social behavior (GO:0035176)2.90915585
112somite development (GO:0061053)2.89816266
113positive regulation of sodium ion transmembrane transport (GO:1902307)2.89107326
114cornea development in camera-type eye (GO:0061303)2.88470229
115spinal cord motor neuron differentiation (GO:0021522)2.88347368
116regulation of neurotransmitter transport (GO:0051588)2.87933705
117water-soluble vitamin biosynthetic process (GO:0042364)2.87669501
118protein complex biogenesis (GO:0070271)2.87051714
119synaptic transmission, cholinergic (GO:0007271)2.86740164
120sodium ion export (GO:0071436)2.84444705
121cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.84435582
122adaptation of signaling pathway (GO:0023058)2.84150913
123synaptic vesicle transport (GO:0048489)2.83655544
124establishment of synaptic vesicle localization (GO:0097480)2.83655544
125regulation of synaptic transmission (GO:0050804)2.83600785
126regulation of cilium movement (GO:0003352)2.83566690
127dendritic spine morphogenesis (GO:0060997)2.83390315
128neuronal action potential (GO:0019228)2.83332561
129platelet dense granule organization (GO:0060155)2.83295274
130behavioral response to ethanol (GO:0048149)2.81668865
131cilium morphogenesis (GO:0060271)2.81069729
132* synapse organization (GO:0050808)2.80645599
133positive regulation of potassium ion transmembrane transport (GO:1901381)2.79958083
134nephron epithelium morphogenesis (GO:0072088)2.79571392
135nephron tubule morphogenesis (GO:0072078)2.79571392
136regulation of neurotransmitter uptake (GO:0051580)2.78383996
137DNA deamination (GO:0045006)2.78352708
138regulation of female receptivity (GO:0045924)2.77559491
139head development (GO:0060322)2.76314576
140neuron fate determination (GO:0048664)2.75420068
141axoneme assembly (GO:0035082)2.73884787
142forebrain neuron differentiation (GO:0021879)2.73047426
143eye photoreceptor cell development (GO:0042462)2.72353419
144epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.66155898
145neural tube formation (GO:0001841)2.66107337
146negative regulation of cytosolic calcium ion concentration (GO:0051481)2.62642608
147negative regulation of transcription regulatory region DNA binding (GO:2000678)2.62577551
148limb bud formation (GO:0060174)2.61987854
149retinal cone cell development (GO:0046549)2.61973268
150epithelial cilium movement (GO:0003351)2.61727669
151regulation of action potential (GO:0098900)2.61427725
152positive regulation of oligodendrocyte differentiation (GO:0048714)2.61224297
153cellular ketone body metabolic process (GO:0046950)2.59540524
154mitochondrial respiratory chain complex assembly (GO:0033108)2.56445430
155kidney morphogenesis (GO:0060993)2.55768832
156piRNA metabolic process (GO:0034587)2.55453145
157mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.54674894
158central nervous system myelination (GO:0022010)2.54202419
159axon ensheathment in central nervous system (GO:0032291)2.54202419
160regulation of microtubule-based movement (GO:0060632)2.53947341
161renal tubule morphogenesis (GO:0061333)2.53601105
162regulation of collateral sprouting (GO:0048670)2.51941696
163* homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.51780679
164spinal cord development (GO:0021510)2.51404179
165respiratory chain complex IV assembly (GO:0008535)2.50836659
166pattern specification involved in kidney development (GO:0061004)2.50811014
167reflex (GO:0060004)2.48185744
168protein neddylation (GO:0045116)2.48022798
169cell differentiation in spinal cord (GO:0021515)2.47623811
170ubiquinone metabolic process (GO:0006743)2.47617965
171cell proliferation in forebrain (GO:0021846)2.44711557
172preassembly of GPI anchor in ER membrane (GO:0016254)2.43832111
173regulation of oligodendrocyte differentiation (GO:0048713)2.43610619
174sulfation (GO:0051923)2.40821295
175regulation of rhodopsin mediated signaling pathway (GO:0022400)2.40291755
176alanine transport (GO:0032328)2.40084160
177intraciliary transport (GO:0042073)2.39937118

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.04931037
2GBX2_23144817_ChIP-Seq_PC3_Human4.27025934
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.09260455
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.03202258
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.83727991
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.61313627
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.61313627
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.60922280
9SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.60549257
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.54886529
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.51141766
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.50948271
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.38502925
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.38442962
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.36702078
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.35206856
17REST_21632747_ChIP-Seq_MESCs_Mouse2.33017351
18EZH2_27294783_Chip-Seq_ESCs_Mouse2.26924822
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.17674446
20RNF2_27304074_Chip-Seq_ESCs_Mouse2.17393963
21TAF15_26573619_Chip-Seq_HEK293_Human2.16667095
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.16133233
23CTBP1_25329375_ChIP-Seq_LNCAP_Human2.05942303
24CTBP2_25329375_ChIP-Seq_LNCAP_Human2.04564211
25DROSHA_22980978_ChIP-Seq_HELA_Human2.02292469
26AR_21572438_ChIP-Seq_LNCaP_Human2.01076371
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.00785390
28RARB_27405468_Chip-Seq_BRAIN_Mouse2.00120474
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.93456393
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.93343930
31REST_18959480_ChIP-ChIP_MESCs_Mouse1.88553792
32CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.84813419
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.84608315
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.83408437
35EWS_26573619_Chip-Seq_HEK293_Human1.81413951
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.76965780
37SMAD4_21799915_ChIP-Seq_A2780_Human1.73553005
38FLI1_27457419_Chip-Seq_LIVER_Mouse1.72988556
39PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.69854072
40BMI1_23680149_ChIP-Seq_NPCS_Mouse1.67339891
41P300_19829295_ChIP-Seq_ESCs_Human1.64928112
42RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.62583331
43POU3F2_20337985_ChIP-ChIP_501MEL_Human1.62451841
44E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.61809642
45SMAD_19615063_ChIP-ChIP_OVARY_Human1.58977803
46GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.58636581
47NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.57421181
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.53702501
49SALL1_21062744_ChIP-ChIP_HESCs_Human1.53469866
50SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52796317
51IKZF1_21737484_ChIP-ChIP_HCT116_Human1.51324590
52FUS_26573619_Chip-Seq_HEK293_Human1.49316700
53PCGF2_27294783_Chip-Seq_ESCs_Mouse1.48227623
54MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.48027019
55IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.47427498
56CBP_20019798_ChIP-Seq_JUKART_Human1.47427498
57OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45211502
58CBX2_27304074_Chip-Seq_ESCs_Mouse1.44249712
59POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.39137717
60TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39137717
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.38435792
62PIAS1_25552417_ChIP-Seq_VCAP_Human1.38116250
63GABP_17652178_ChIP-ChIP_JURKAT_Human1.37385962
64VDR_22108803_ChIP-Seq_LS180_Human1.37241194
65ZNF274_21170338_ChIP-Seq_K562_Hela1.37138955
66SOX2_21211035_ChIP-Seq_LN229_Gbm1.36145108
67AR_25329375_ChIP-Seq_VCAP_Human1.34628020
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32899559
69MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.32336308
70PCGF2_27294783_Chip-Seq_NPCs_Mouse1.31514542
71STAT3_23295773_ChIP-Seq_U87_Human1.30699143
72RBPJ_22232070_ChIP-Seq_NCS_Mouse1.30434809
73EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.30403167
74NR3C1_23031785_ChIP-Seq_PC12_Mouse1.29578830
75GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.27363774
76TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.27268772
77ARNT_22903824_ChIP-Seq_MCF-7_Human1.27046640
78RING1B_27294783_Chip-Seq_ESCs_Mouse1.26844434
79PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.26421380
80AHR_22903824_ChIP-Seq_MCF-7_Human1.26322653
81RNF2_27304074_Chip-Seq_NSC_Mouse1.24646244
82KLF5_20875108_ChIP-Seq_MESCs_Mouse1.23192308
83TP53_22573176_ChIP-Seq_HFKS_Human1.22933786
84EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20657336
85VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.19972400
86AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19238385
87IGF1R_20145208_ChIP-Seq_DFB_Human1.18824838
88ER_23166858_ChIP-Seq_MCF-7_Human1.18335728
89ZNF217_24962896_ChIP-Seq_MCF-7_Human1.18165267
90TCF4_23295773_ChIP-Seq_U87_Human1.18099813
91TCF4_22108803_ChIP-Seq_LS180_Human1.16916736
92POU5F1_16153702_ChIP-ChIP_HESCs_Human1.16573717
93FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.14680451
94AR_19668381_ChIP-Seq_PC3_Human1.14534313
95MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.14121219
96RING1B_27294783_Chip-Seq_NPCs_Mouse1.13643171
97MYC_18940864_ChIP-ChIP_HL60_Human1.12998180
98UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11813163
99SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10272444
100SOX2_19829295_ChIP-Seq_ESCs_Human1.09954392
101NANOG_19829295_ChIP-Seq_ESCs_Human1.09954392
102IRF1_19129219_ChIP-ChIP_H3396_Human1.08957028
103ETV2_25802403_ChIP-Seq_MESCs_Mouse1.08098991
104FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.07030106
105PRDM14_20953172_ChIP-Seq_ESCs_Human1.06974517
106EST1_17652178_ChIP-ChIP_JURKAT_Human1.06623729
107RUNX2_22187159_ChIP-Seq_PCA_Human1.06281907
108YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06104920
109SMAD4_21741376_ChIP-Seq_EPCs_Human1.04944892
110KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.04911506
111ERG_21242973_ChIP-ChIP_JURKAT_Human1.04042481
112P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03792135
113CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.03763890
114EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03731082
115CDX2_19796622_ChIP-Seq_MESCs_Mouse1.03224363
116MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03142151
117JUN_21703547_ChIP-Seq_K562_Human1.03115579
118NFE2_27457419_Chip-Seq_LIVER_Mouse1.02474632
119EZH2_27294783_Chip-Seq_NPCs_Mouse1.01891834
120BCAT_22108803_ChIP-Seq_LS180_Human1.01853385
121FLI1_21867929_ChIP-Seq_TH2_Mouse1.00810566
122WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99625243
123MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98967014
124TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97267366
125RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.95453864
126SMAD4_21741376_ChIP-Seq_HESCs_Human0.93586798
127TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93521676
128NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93233355
129DNAJC2_21179169_ChIP-ChIP_NT2_Human0.92852012
130SMAD3_21741376_ChIP-Seq_HESCs_Human0.92768598
131TP53_18474530_ChIP-ChIP_U2OS_Human0.91146687
132TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.90206025
133SOX9_26525672_Chip-Seq_HEART_Mouse0.90024915
134ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.89578068
135NANOG_18555785_Chip-Seq_ESCs_Mouse0.89547124
136TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86971471
137KDM2B_26808549_Chip-Seq_REH_Human0.86843193

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.78763124
2MP0003880_abnormal_central_pattern4.64120424
3MP0003635_abnormal_synaptic_transmissio3.69186209
4MP0004270_analgesia3.27433089
5MP0009745_abnormal_behavioral_response3.17157424
6MP0001984_abnormal_olfaction3.08288890
7MP0002063_abnormal_learning/memory/cond3.06466813
8MP0002064_seizures2.96323119
9MP0009046_muscle_twitch2.73325439
10MP0001968_abnormal_touch/_nociception2.61019547
11MP0003787_abnormal_imprinting2.58603314
12MP0002272_abnormal_nervous_system2.58303479
13MP0002572_abnormal_emotion/affect_behav2.56795531
14MP0001486_abnormal_startle_reflex2.55586311
15MP0002734_abnormal_mechanical_nocicepti2.51638496
16MP0000569_abnormal_digit_pigmentation2.47391935
17MP0002822_catalepsy2.44760753
18MP0005551_abnormal_eye_electrophysiolog2.40058350
19MP0002102_abnormal_ear_morphology2.31487297
20MP0001501_abnormal_sleep_pattern2.17288679
21MP0002067_abnormal_sensory_capabilities2.15797774
22MP0002735_abnormal_chemical_nociception2.14915720
23MP0001440_abnormal_grooming_behavior2.11547722
24MP0003136_yellow_coat_color2.10512760
25MP0005423_abnormal_somatic_nervous2.10243348
26MP0006276_abnormal_autonomic_nervous2.07346261
27MP0002736_abnormal_nociception_after2.06127953
28MP0002184_abnormal_innervation1.94230972
29MP0000778_abnormal_nervous_system1.90861245
30MP0009379_abnormal_foot_pigmentation1.87201475
31MP0003195_calcinosis1.82562820
32MP0005394_taste/olfaction_phenotype1.81502612
33MP0005499_abnormal_olfactory_system1.81502612
34MP0008569_lethality_at_weaning1.73243864
35MP0008789_abnormal_olfactory_epithelium1.71778391
36MP0001970_abnormal_pain_threshold1.71531142
37MP0010386_abnormal_urinary_bladder1.71036769
38MP0003646_muscle_fatigue1.62254899
39MP0002090_abnormal_vision1.59373888
40MP0002882_abnormal_neuron_morphology1.58475304
41MP0002557_abnormal_social/conspecific_i1.54743178
42MP0001529_abnormal_vocalization1.53700373
43MP0003329_amyloid_beta_deposits1.53251894
44MP0001502_abnormal_circadian_rhythm1.49266235
45MP0002938_white_spotting1.48086097
46MP0005386_behavior/neurological_phenoty1.47205155
47MP0004924_abnormal_behavior1.47205155
48MP0002733_abnormal_thermal_nociception1.46964137
49MP0000955_abnormal_spinal_cord1.46764638
50MP0004133_heterotaxia1.45052890
51MP0001188_hyperpigmentation1.44938525
52MP0004811_abnormal_neuron_physiology1.44051224
53MP0005171_absent_coat_pigmentation1.41613170
54MP0005187_abnormal_penis_morphology1.38646901
55MP0001986_abnormal_taste_sensitivity1.37923819
56MP0005646_abnormal_pituitary_gland1.37237971
57MP0002909_abnormal_adrenal_gland1.34176233
58MP0006072_abnormal_retinal_apoptosis1.33894033
59MP0000049_abnormal_middle_ear1.33255486
60MP0002066_abnormal_motor_capabilities/c1.32492244
61MP0000372_irregular_coat_pigmentation1.31853674
62MP0003879_abnormal_hair_cell1.31128354
63MP0004142_abnormal_muscle_tone1.30812457
64MP0004742_abnormal_vestibular_system1.28210244
65MP0002229_neurodegeneration1.25475434
66MP0001905_abnormal_dopamine_level1.25141580
67MP0004858_abnormal_nervous_system1.24757702
68MP0000751_myopathy1.23241997
69MP0004043_abnormal_pH_regulation1.19295927
70MP0003633_abnormal_nervous_system1.18339237
71MP0005084_abnormal_gallbladder_morpholo1.17527721
72MP0005253_abnormal_eye_physiology1.15516524
73MP0002163_abnormal_gland_morphology1.14660636
74MP0004885_abnormal_endolymph1.14653353
75MP0002752_abnormal_somatic_nervous1.13683590
76MP0001177_atelectasis1.12148868
77MP0009780_abnormal_chondrocyte_physiolo1.11716149
78MP0003011_delayed_dark_adaptation1.09367801
79MP0005645_abnormal_hypothalamus_physiol1.09196483
80MP0004215_abnormal_myocardial_fiber1.09172887
81MP0002152_abnormal_brain_morphology1.09143769
82MP0005174_abnormal_tail_pigmentation1.08039030
83MP0001485_abnormal_pinna_reflex1.06849483
84MP0002234_abnormal_pharynx_morphology1.05059032
85MP0005379_endocrine/exocrine_gland_phen1.04606993
86MP0003283_abnormal_digestive_organ1.04214187
87MP0001963_abnormal_hearing_physiology1.03439398
88MP0003634_abnormal_glial_cell1.03153090
89MP0003631_nervous_system_phenotype1.02983927
90MP0005623_abnormal_meninges_morphology1.00185386
91MP0002751_abnormal_autonomic_nervous0.99424820
92MP0003938_abnormal_ear_development0.99151536
93MP0000427_abnormal_hair_cycle0.98756272
94MP0005195_abnormal_posterior_eye0.98442994
95MP0003890_abnormal_embryonic-extraembry0.96507930
96MP0003567_abnormal_fetal_cardiomyocyte0.95640440
97MP0003937_abnormal_limbs/digits/tail_de0.95211749
98MP0004085_abnormal_heartbeat0.95064244
99MP0003119_abnormal_digestive_system0.94272471
100MP0003950_abnormal_plasma_membrane0.93335202
101MP0003137_abnormal_impulse_conducting0.93317449
102MP0002876_abnormal_thyroid_physiology0.92760013
103MP0000013_abnormal_adipose_tissue0.92369548
104MP0002069_abnormal_eating/drinking_beha0.91818802
105MP0000631_abnormal_neuroendocrine_gland0.91646419
106MP0008877_abnormal_DNA_methylation0.88821274
107MP0002638_abnormal_pupillary_reflex0.86872696
108MP0001324_abnormal_eye_pigmentation0.85501298
109MP0004233_abnormal_muscle_weight0.83971143
110MP0005367_renal/urinary_system_phenotyp0.83469708
111MP0000516_abnormal_urinary_system0.83469708
112MP0001919_abnormal_reproductive_system0.81320491
113MP0003755_abnormal_palate_morphology0.81256536
114MP0008875_abnormal_xenobiotic_pharmacok0.80377589
115MP0003122_maternal_imprinting0.79978161
116MP0000383_abnormal_hair_follicle0.79903673
117MP0008872_abnormal_physiological_respon0.76113261
118MP0000920_abnormal_myelination0.74135521
119MP0002837_dystrophic_cardiac_calcinosis0.73163874
120MP0003632_abnormal_nervous_system0.68912802
121MP0000026_abnormal_inner_ear0.67652199
122MP0003690_abnormal_glial_cell0.67161161
123MP0008874_decreased_physiological_sensi0.66483576
124MP0003861_abnormal_nervous_system0.64831739
125MP0004145_abnormal_muscle_electrophysio0.64785665
126MP0000604_amyloidosis0.63846415
127MP0006292_abnormal_olfactory_placode0.61727922
128MP0001943_abnormal_respiration0.60630832
129MP0002653_abnormal_ependyma_morphology0.57887876
130MP0003121_genomic_imprinting0.55362387
131MP0000534_abnormal_ureter_morphology0.54540842

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.30893000
2Epileptic encephalopathy (HP:0200134)5.88311016
3Atonic seizures (HP:0010819)5.75431678
4Febrile seizures (HP:0002373)5.46787297
5Myokymia (HP:0002411)5.19102640
6Focal seizures (HP:0007359)4.84781664
7Absence seizures (HP:0002121)4.84049348
8Congenital stationary night blindness (HP:0007642)4.45441994
9Dialeptic seizures (HP:0011146)4.26375699
10Progressive cerebellar ataxia (HP:0002073)4.21388045
11Hyperventilation (HP:0002883)4.02251126
12Pancreatic cysts (HP:0001737)3.95468395
13Abnormality of midbrain morphology (HP:0002418)3.87427513
14Molar tooth sign on MRI (HP:0002419)3.87427513
15Generalized tonic-clonic seizures (HP:0002069)3.72455749
16Pancreatic fibrosis (HP:0100732)3.71846600
17True hermaphroditism (HP:0010459)3.71730458
18Nephronophthisis (HP:0000090)3.71397445
19Visual hallucinations (HP:0002367)3.65967499
20Central scotoma (HP:0000603)3.36774687
21Broad-based gait (HP:0002136)3.23077769
22Abnormality of macular pigmentation (HP:0008002)3.17230577
23Chorioretinal atrophy (HP:0000533)3.11382973
24Abnormality of the renal medulla (HP:0100957)3.07885635
25Abolished electroretinogram (ERG) (HP:0000550)3.07122929
26Dysdiadochokinesis (HP:0002075)3.02455144
27Abnormal hair whorl (HP:0010721)3.00100518
28Amblyopia (HP:0000646)2.93257957
29Gaze-evoked nystagmus (HP:0000640)2.88258265
30Ankle clonus (HP:0011448)2.86485038
31Gait imbalance (HP:0002141)2.83119723
32Truncal ataxia (HP:0002078)2.82983773
33Excessive salivation (HP:0003781)2.79332345
34Drooling (HP:0002307)2.79332345
35Polyphagia (HP:0002591)2.76627362
36Pendular nystagmus (HP:0012043)2.75995681
37Abnormal rod and cone electroretinograms (HP:0008323)2.71294816
38Supranuclear gaze palsy (HP:0000605)2.66318113
39Impaired vibration sensation in the lower limbs (HP:0002166)2.64606746
40Abnormal eating behavior (HP:0100738)2.63935071
41Depression (HP:0000716)2.63665101
42Sclerocornea (HP:0000647)2.62736875
43Type II lissencephaly (HP:0007260)2.62174356
44Hypothermia (HP:0002045)2.60763930
45Dysmetria (HP:0001310)2.59131066
46Action tremor (HP:0002345)2.58112342
47Lissencephaly (HP:0001339)2.55070353
48Epileptiform EEG discharges (HP:0011182)2.54643659
49Congenital primary aphakia (HP:0007707)2.50747081
50Chronic hepatic failure (HP:0100626)2.49948319
51Abnormality of the renal cortex (HP:0011035)2.47803012
52Cystic liver disease (HP:0006706)2.47396105
53Acute necrotizing encephalopathy (HP:0006965)2.42350791
54Abnormal drinking behavior (HP:0030082)2.41662008
55Polydipsia (HP:0001959)2.41662008
56Nephrogenic diabetes insipidus (HP:0009806)2.40582341
57Abnormal social behavior (HP:0012433)2.40358414
58Impaired social interactions (HP:0000735)2.40358414
59Agitation (HP:0000713)2.39933420
60Attenuation of retinal blood vessels (HP:0007843)2.39675816
61Abnormality of the labia minora (HP:0012880)2.39106946
62Abnormality of the lower motor neuron (HP:0002366)2.37015517
63Neurofibrillary tangles (HP:0002185)2.34452634
64Poor eye contact (HP:0000817)2.33858235
65Decreased central vision (HP:0007663)2.32088870
66Absent rod-and cone-mediated responses on ERG (HP:0007688)2.31449952
67Severe muscular hypotonia (HP:0006829)2.29913925
68Progressive macrocephaly (HP:0004481)2.29805134
69Mutism (HP:0002300)2.27492895
70Scanning speech (HP:0002168)2.25856790
71Methylmalonic acidemia (HP:0002912)2.24996296
72EEG with generalized epileptiform discharges (HP:0011198)2.24782659
73Anencephaly (HP:0002323)2.24490330
74Hemiplegia (HP:0002301)2.22787843
75Pachygyria (HP:0001302)2.22776520
76Intestinal atresia (HP:0011100)2.22015733
77Urinary bladder sphincter dysfunction (HP:0002839)2.21983546
78Postural instability (HP:0002172)2.21966604
79Scotoma (HP:0000575)2.19968468
80Medial flaring of the eyebrow (HP:0010747)2.19628577
81Termporal pattern (HP:0011008)2.18987798
82Insidious onset (HP:0003587)2.18987798
83Anxiety (HP:0000739)2.18039392
84Cerebral inclusion bodies (HP:0100314)2.17476431
85Concave nail (HP:0001598)2.17159227
86Mitochondrial inheritance (HP:0001427)2.17130549
87Genital tract atresia (HP:0001827)2.17062498
88Rib fusion (HP:0000902)2.17036050
89Hemiparesis (HP:0001269)2.16513187
90Protruding tongue (HP:0010808)2.16326312
91Tubular atrophy (HP:0000092)2.15174890
92Spastic gait (HP:0002064)2.14643173
93Aplasia/Hypoplasia of the tongue (HP:0010295)2.14239582
94Postaxial foot polydactyly (HP:0001830)2.13971398
95Congenital, generalized hypertrichosis (HP:0004540)2.13615111
96Acute encephalopathy (HP:0006846)2.10335681
97Vaginal atresia (HP:0000148)2.10092945
98Absent speech (HP:0001344)2.07846266
99Palpebral edema (HP:0100540)2.07460317
100Retinal dysplasia (HP:0007973)2.05996257
101Lower limb muscle weakness (HP:0007340)2.05815864
102Increased corneal curvature (HP:0100692)2.05102609
103Keratoconus (HP:0000563)2.05102609
104Pheochromocytoma (HP:0002666)2.04753853
105Methylmalonic aciduria (HP:0012120)2.03581269
106Postaxial hand polydactyly (HP:0001162)2.03557415
107Congenital hepatic fibrosis (HP:0002612)2.03493508
108Abnormality of salivation (HP:0100755)2.03459943
109Abnormal gallbladder physiology (HP:0012438)2.02762958
110Cholecystitis (HP:0001082)2.02762958
111Abnormal mitochondria in muscle tissue (HP:0008316)2.01503456
1123-Methylglutaconic aciduria (HP:0003535)2.00650282
113Optic nerve hypoplasia (HP:0000609)2.00479397
114Septo-optic dysplasia (HP:0100842)2.00187043
115Inability to walk (HP:0002540)1.99770584
116Bony spicule pigmentary retinopathy (HP:0007737)1.99216580
117Increased CSF lactate (HP:0002490)1.99087925
118Abnormality of the corticospinal tract (HP:0002492)1.99084050
119Specific learning disability (HP:0001328)1.98849666
120Generalized myoclonic seizures (HP:0002123)1.98634564
121Degeneration of the lateral corticospinal tracts (HP:0002314)1.98106891
122Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.98106891
123Optic disc pallor (HP:0000543)1.97530760
124Narrow forehead (HP:0000341)1.93761454
125Impaired smooth pursuit (HP:0007772)1.93549184
126Torticollis (HP:0000473)1.93363587
127Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.91229935
128Blue irides (HP:0000635)1.90398421
129Renal cortical cysts (HP:0000803)1.89812621
130Bradykinesia (HP:0002067)1.89469320
131Incomplete penetrance (HP:0003829)1.89289544
132Poor coordination (HP:0002370)1.87460745
133Impaired pain sensation (HP:0007328)1.86515262
134Abnormality of pain sensation (HP:0010832)1.86515262
135Hypoventilation (HP:0002791)1.86308660
136Male pseudohermaphroditism (HP:0000037)1.84221750
137Growth hormone deficiency (HP:0000824)1.83681930
138Limb dystonia (HP:0002451)1.83178625
139Fetal akinesia sequence (HP:0001989)1.82552618
140Large for gestational age (HP:0001520)1.81487370
141Progressive inability to walk (HP:0002505)1.81120069
142Syncope (HP:0001279)1.80779555
143Furrowed tongue (HP:0000221)1.79672916
144Dysmetric saccades (HP:0000641)1.79636170
145Genetic anticipation (HP:0003743)1.79238129
146Increased hepatocellular lipid droplets (HP:0006565)1.78979521
147Hypsarrhythmia (HP:0002521)1.78802430
148Failure to thrive in infancy (HP:0001531)1.78394258
149Sensory axonal neuropathy (HP:0003390)1.78122757
150Colon cancer (HP:0003003)1.77249027
151Polyuria (HP:0000103)1.76702297
152Prolonged QT interval (HP:0001657)1.76679649
153Patellar aplasia (HP:0006443)1.75034852
154Aplasia/Hypoplasia of the patella (HP:0006498)1.74843039
155Adrenal hypoplasia (HP:0000835)1.73562522
156Anophthalmia (HP:0000528)1.72664651
157Lipid accumulation in hepatocytes (HP:0006561)1.71997909
158Diplopia (HP:0000651)1.71237803
159Abnormality of binocular vision (HP:0011514)1.71237803
160Akinesia (HP:0002304)1.71133034
161Impaired vibratory sensation (HP:0002495)1.70069509
162Anosmia (HP:0000458)1.69644992
163Urinary urgency (HP:0000012)1.68566809
164Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.67905726
165Focal dystonia (HP:0004373)1.67016131
166Decreased circulating renin level (HP:0003351)1.66731302

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.21878706
2BMPR24.01784110
3FRK4.00800475
4ERBB33.89419462
5NTRK33.27331184
6EPHA43.24979317
7MARK12.74519198
8NTRK22.64438738
9MAP2K72.62803331
10MAP3K42.51098519
11PRPF4B2.45314682
12ADRBK22.43050849
13GRK12.41559264
14MINK12.38604968
15DYRK22.28806713
16MAP4K22.15573618
17DAPK21.98118431
18WNK41.93554466
19TNIK1.83898533
20PAK61.79310690
21MKNK21.70336144
22SIK31.64348929
23SIK21.61571764
24TRIM281.55178220
25EPHA31.54212356
26MAP2K41.50807850
27CDK191.44545447
28PLK21.40489558
29NUAK11.39502453
30CSNK1G11.38240714
31NTRK11.31083297
32CDK51.30558070
33MAPK131.30114218
34MAP3K121.29626986
35FES1.25814139
36BCKDK1.25749600
37MAP3K91.23451292
38GRK51.23125284
39CSNK1A1L1.23050449
40SGK4941.18899203
41SGK2231.18899203
42OXSR11.18233200
43CAMK2A1.17773400
44PNCK1.15995466
45PHKG21.15535854
46PHKG11.15535854
47DAPK11.15461508
48ZAK1.12527135
49PRKCG1.09641831
50CAMK2B1.08907148
51TIE11.08106516
52PBK1.07900773
53STK161.06970003
54AKT31.05022268
55MARK21.02163050
56FER0.98547573
57NEK10.98455733
58DYRK1A0.97144928
59ADRBK10.94837074
60CAMK2D0.94184927
61UHMK10.93609273
62LIMK10.88619722
63STK380.87595450
64PRKCE0.86185998
65STK38L0.85918133
66CDK140.85121200
67MAPKAPK30.82544851
68CDK180.81581340
69BCR0.81056115
70STK390.80270116
71RIPK40.79720650
72CDK150.78994323
73MAPK150.78616453
74CAMKK10.77276571
75TGFBR10.77209367
76EPHB20.76814041
77LMTK20.76551940
78KSR20.76026706
79TLK10.75035965
80PRKD30.74544025
81SGK20.72670592
82MKNK10.72642192
83CAMKK20.71932994
84TXK0.71325844
85CDK11A0.69277747
86MAP3K130.68524917
87VRK10.68513578
88MAP3K20.68413675
89CSNK1G20.68148128
90TAOK30.66024447
91KSR10.65423822
92CAMK10.64947696
93CDK30.64034288
94MAPKAPK50.62986141
95PKN10.62480836
96FGFR20.60777375
97CCNB10.60442010
98NME10.60313340
99TNK20.59453036
100CAMK2G0.59311931
101PTK2B0.59294737
102PIK3CA0.56467127
103DYRK30.55746777
104PLK30.55602225
105SGK10.55561697
106PAK30.53837190
107ACVR1B0.53011321
108CSNK1A10.51782862
109ROCK20.49348553
110MAP3K70.49146125
111ERBB20.49071064
112PRKCI0.47646513
113MUSK0.47414896
114RPS6KA50.46975404
115TYRO30.46756458
116WNK30.46346050
117CSNK1D0.44960948
118BMPR1B0.43903879
119STK110.43722758
120GRK70.43431443
121PRKCH0.41704032
122PINK10.40450213
123PLK40.39722718
124TSSK60.38995304
125PRKG10.37877145
126MAP2K10.37446463
127NEK90.36890038
128PRKACA0.36423668
129SGK30.35959894
130RPS6KA20.35452685
131RPS6KA30.35052072
132PRKAA10.33901662
133FYN0.33729283
134MAP3K10.33450459
135CSNK1G30.33281659
136CSNK1E0.33138480
137PRKCQ0.33102733
138CAMK40.33002912
139PRKCB0.32503133
140MAPK100.32450253
141INSRR0.32403727
142ABL20.31648954
143MAPK120.31484096
144PRKCZ0.31339109
145PRKCA0.31069659
146ERBB40.30806894
147NEK60.30365973

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.68256022
2Synaptic vesicle cycle_Homo sapiens_hsa047213.59099375
3GABAergic synapse_Homo sapiens_hsa047273.36927462
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.21406571
5Morphine addiction_Homo sapiens_hsa050323.06399672
6Olfactory transduction_Homo sapiens_hsa047402.81550761
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.80042230
8Circadian entrainment_Homo sapiens_hsa047132.75906379
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.60482986
10Glutamatergic synapse_Homo sapiens_hsa047242.56023515
11Taste transduction_Homo sapiens_hsa047422.32743028
12Collecting duct acid secretion_Homo sapiens_hsa049662.29252055
13Protein export_Homo sapiens_hsa030602.22375121
14Parkinsons disease_Homo sapiens_hsa050122.22042083
15Dopaminergic synapse_Homo sapiens_hsa047282.14848087
16Long-term potentiation_Homo sapiens_hsa047202.08073851
17Amphetamine addiction_Homo sapiens_hsa050312.01311269
18Serotonergic synapse_Homo sapiens_hsa047262.00876598
19Cholinergic synapse_Homo sapiens_hsa047252.00750055
20Salivary secretion_Homo sapiens_hsa049701.94554188
21Insulin secretion_Homo sapiens_hsa049111.84721274
22Renin secretion_Homo sapiens_hsa049241.80945364
23Linoleic acid metabolism_Homo sapiens_hsa005911.78429791
24Nitrogen metabolism_Homo sapiens_hsa009101.73675509
25alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.73178792
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.63937338
27RNA polymerase_Homo sapiens_hsa030201.62955512
28Oxytocin signaling pathway_Homo sapiens_hsa049211.55162458
29Long-term depression_Homo sapiens_hsa047301.50337574
30Gastric acid secretion_Homo sapiens_hsa049711.48077373
31Huntingtons disease_Homo sapiens_hsa050161.46804247
32Calcium signaling pathway_Homo sapiens_hsa040201.46787714
33Aldosterone synthesis and secretion_Homo sapiens_hsa049251.42348260
34Selenocompound metabolism_Homo sapiens_hsa004501.41948914
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.41087411
36Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.40212033
37Vibrio cholerae infection_Homo sapiens_hsa051101.40005714
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.39133455
39Axon guidance_Homo sapiens_hsa043601.38676009
40Basal transcription factors_Homo sapiens_hsa030221.34969974
41Ether lipid metabolism_Homo sapiens_hsa005651.34653899
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.32563958
43Propanoate metabolism_Homo sapiens_hsa006401.32513559
44Phototransduction_Homo sapiens_hsa047441.30277950
45Maturity onset diabetes of the young_Homo sapiens_hsa049501.29229955
46Cocaine addiction_Homo sapiens_hsa050301.26942483
47Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.25481389
48Peroxisome_Homo sapiens_hsa041461.23429007
49Gap junction_Homo sapiens_hsa045401.19996237
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.18994737
51Steroid biosynthesis_Homo sapiens_hsa001001.14283855
52Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.14115806
53Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.12381807
54Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.12135104
55GnRH signaling pathway_Homo sapiens_hsa049121.10413017
56cAMP signaling pathway_Homo sapiens_hsa040241.09084980
57Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.08419671
58Cardiac muscle contraction_Homo sapiens_hsa042601.05884100
59Primary bile acid biosynthesis_Homo sapiens_hsa001201.01831179
60Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.99392611
61Caffeine metabolism_Homo sapiens_hsa002320.98777694
62Tryptophan metabolism_Homo sapiens_hsa003800.96960986
63RNA degradation_Homo sapiens_hsa030180.96229340
64Dilated cardiomyopathy_Homo sapiens_hsa054140.92818516
65Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.91586137
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.90323143
67Phosphatidylinositol signaling system_Homo sapiens_hsa040700.89945786
68Type II diabetes mellitus_Homo sapiens_hsa049300.89077221
69cGMP-PKG signaling pathway_Homo sapiens_hsa040220.85073880
70Circadian rhythm_Homo sapiens_hsa047100.84632224
71Vascular smooth muscle contraction_Homo sapiens_hsa042700.82991977
72Hedgehog signaling pathway_Homo sapiens_hsa043400.80077118
73Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.79553177
74Ribosome_Homo sapiens_hsa030100.75199270
75Steroid hormone biosynthesis_Homo sapiens_hsa001400.74293958
76ErbB signaling pathway_Homo sapiens_hsa040120.73134077
77Pancreatic secretion_Homo sapiens_hsa049720.72939447
78Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.70253266
79Glioma_Homo sapiens_hsa052140.69269383
80ABC transporters_Homo sapiens_hsa020100.68878651
81Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68869436
82Homologous recombination_Homo sapiens_hsa034400.68437361
83Melanogenesis_Homo sapiens_hsa049160.68151735
84beta-Alanine metabolism_Homo sapiens_hsa004100.67627047
85Estrogen signaling pathway_Homo sapiens_hsa049150.65821974
86Proteasome_Homo sapiens_hsa030500.65766421
87Retinol metabolism_Homo sapiens_hsa008300.63825212
88MAPK signaling pathway_Homo sapiens_hsa040100.62856914
89Rheumatoid arthritis_Homo sapiens_hsa053230.62573029
90Fanconi anemia pathway_Homo sapiens_hsa034600.62452576
91Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.62237600
92Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62043503
93Alcoholism_Homo sapiens_hsa050340.61062713
94Metabolic pathways_Homo sapiens_hsa011000.59431341
95Thyroid hormone synthesis_Homo sapiens_hsa049180.58409252
96Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.58368322
97Ras signaling pathway_Homo sapiens_hsa040140.58236541
98Basal cell carcinoma_Homo sapiens_hsa052170.57576533
99Chemical carcinogenesis_Homo sapiens_hsa052040.57553110
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56746395
101Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54510949
102Phospholipase D signaling pathway_Homo sapiens_hsa040720.54366611
103Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53326535
104Alzheimers disease_Homo sapiens_hsa050100.53272772
105Purine metabolism_Homo sapiens_hsa002300.52585095
106Fat digestion and absorption_Homo sapiens_hsa049750.50480366
107Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.49988281
108Glycerolipid metabolism_Homo sapiens_hsa005610.49559486
109Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.48694405
110Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48553888
111Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48542901
112Inositol phosphate metabolism_Homo sapiens_hsa005620.47976735
113Choline metabolism in cancer_Homo sapiens_hsa052310.47820951
114Oocyte meiosis_Homo sapiens_hsa041140.46129011
115Oxidative phosphorylation_Homo sapiens_hsa001900.44324607
116Bile secretion_Homo sapiens_hsa049760.43562004
117Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43059477
118Ovarian steroidogenesis_Homo sapiens_hsa049130.40775302
119Rap1 signaling pathway_Homo sapiens_hsa040150.40185452
120Histidine metabolism_Homo sapiens_hsa003400.40156338
121Arachidonic acid metabolism_Homo sapiens_hsa005900.39970687
122Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.39406463
123Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.39052989
124Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38422331
125Phagosome_Homo sapiens_hsa041450.37963643
126Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37769031
127Cysteine and methionine metabolism_Homo sapiens_hsa002700.35795345
128Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.35434740
129SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34704635
130Fatty acid biosynthesis_Homo sapiens_hsa000610.34691021
131Glucagon signaling pathway_Homo sapiens_hsa049220.33831362
132Hippo signaling pathway_Homo sapiens_hsa043900.33452771
133Dorso-ventral axis formation_Homo sapiens_hsa043200.32924756
134African trypanosomiasis_Homo sapiens_hsa051430.29953019
135Sulfur metabolism_Homo sapiens_hsa009200.28192679
136Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.27730678
137Regulation of autophagy_Homo sapiens_hsa041400.27578194
138Sphingolipid signaling pathway_Homo sapiens_hsa040710.26781467
139Fatty acid metabolism_Homo sapiens_hsa012120.26760749
140Melanoma_Homo sapiens_hsa052180.25180424
141Endocytosis_Homo sapiens_hsa041440.24983624
142Chemokine signaling pathway_Homo sapiens_hsa040620.24868590
143Wnt signaling pathway_Homo sapiens_hsa043100.24706702
144Mineral absorption_Homo sapiens_hsa049780.24565815
145Carbohydrate digestion and absorption_Homo sapiens_hsa049730.24351234
146Butanoate metabolism_Homo sapiens_hsa006500.23647304
147Prion diseases_Homo sapiens_hsa050200.22485816
148Thyroid hormone signaling pathway_Homo sapiens_hsa049190.22186617
149Renal cell carcinoma_Homo sapiens_hsa052110.20807274
150Tight junction_Homo sapiens_hsa045300.20159987
151Sphingolipid metabolism_Homo sapiens_hsa006000.17658850
152Endometrial cancer_Homo sapiens_hsa052130.16815043

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