PCDHB19P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of synaptic transmission, glutamatergic (GO:0051967)7.38083759
2fucose catabolic process (GO:0019317)6.20521318
3L-fucose metabolic process (GO:0042354)6.20521318
4L-fucose catabolic process (GO:0042355)6.20521318
5activated T cell proliferation (GO:0050798)5.18790237
6tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.76945365
7RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.76945365
8positive regulation of catecholamine secretion (GO:0033605)4.61288550
9behavioral response to nicotine (GO:0035095)4.58498859
10negative regulation of membrane potential (GO:0045837)4.10979551
11cardiac left ventricle morphogenesis (GO:0003214)4.09609166
12fucosylation (GO:0036065)4.04087099
13acrosome reaction (GO:0007340)3.97398958
14regulation of feeding behavior (GO:0060259)3.79039974
15regulation of dopamine secretion (GO:0014059)3.78338931
16regulation of non-canonical Wnt signaling pathway (GO:2000050)3.75580579
17transmission of nerve impulse (GO:0019226)3.71773072
18peristalsis (GO:0030432)3.69368076
19mechanosensory behavior (GO:0007638)3.61096868
20indolalkylamine metabolic process (GO:0006586)3.56851914
21behavioral response to ethanol (GO:0048149)3.56392978
22kynurenine metabolic process (GO:0070189)3.55526673
23negative regulation of neurological system process (GO:0031645)3.53441528
24substrate-independent telencephalic tangential migration (GO:0021826)3.33657996
25substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.33657996
26viral transcription (GO:0019083)3.32259935
27negative regulation of Rho protein signal transduction (GO:0035024)3.30772301
28sequestering of actin monomers (GO:0042989)3.25555901
29retinal ganglion cell axon guidance (GO:0031290)3.22499461
30positive regulation of fatty acid oxidation (GO:0046321)3.20596850
31translational termination (GO:0006415)3.18951414
32detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.11476176
33platelet dense granule organization (GO:0060155)3.02413985
34response to histamine (GO:0034776)3.00904244
35epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.00280413
36regulation of circadian sleep/wake cycle, sleep (GO:0045187)2.97135728
37regulation of circadian sleep/wake cycle (GO:0042749)2.97135728
38indole-containing compound catabolic process (GO:0042436)2.95129394
39indolalkylamine catabolic process (GO:0046218)2.95129394
40tryptophan catabolic process (GO:0006569)2.95129394
41inner ear receptor cell development (GO:0060119)2.94315962
42somite development (GO:0061053)2.91903217
43mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.91842909
44mitochondrial respiratory chain complex I assembly (GO:0032981)2.91842909
45NADH dehydrogenase complex assembly (GO:0010257)2.91842909
46phosphorylated carbohydrate dephosphorylation (GO:0046838)2.89334840
47inositol phosphate dephosphorylation (GO:0046855)2.89334840
48nonmotile primary cilium assembly (GO:0035058)2.88813612
49nitric oxide mediated signal transduction (GO:0007263)2.87067735
50regulation of action potential (GO:0098900)2.86423998
51cotranslational protein targeting to membrane (GO:0006613)2.86310594
52detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)2.86240562
53G-protein coupled receptor internalization (GO:0002031)2.85585061
54positive regulation of amine transport (GO:0051954)2.85418864
55SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.85268012
56inositol phosphate catabolic process (GO:0071545)2.84498709
57sulfation (GO:0051923)2.84256721
58respiratory chain complex IV assembly (GO:0008535)2.83362095
59positive regulation of fatty acid transport (GO:2000193)2.81546856
60regulation of glucokinase activity (GO:0033131)2.81336369
61regulation of hexokinase activity (GO:1903299)2.81336369
62inositol metabolic process (GO:0006020)2.79554256
63phasic smooth muscle contraction (GO:0014821)2.79427990
64protein targeting to ER (GO:0045047)2.78722327
65positive regulation of action potential (GO:0045760)2.78190674
66valine metabolic process (GO:0006573)2.75103693
67epithelial cilium movement (GO:0003351)2.74998367
68negative regulation of synaptic transmission, GABAergic (GO:0032229)2.74572852
69fucose metabolic process (GO:0006004)2.73000766
70protein complex biogenesis (GO:0070271)2.72856014
71tRNA processing (GO:0008033)2.72585082
72neuron fate determination (GO:0048664)2.72055597
73intraciliary transport (GO:0042073)2.71942818
74startle response (GO:0001964)2.68264982
75detection of chemical stimulus involved in sensory perception of taste (GO:0050912)2.68185943
76negative regulation of mast cell activation (GO:0033004)2.66716074
77negative regulation of oligodendrocyte differentiation (GO:0048715)2.66287303
78regulation of rhodopsin mediated signaling pathway (GO:0022400)2.63796135
79establishment of protein localization to endoplasmic reticulum (GO:0072599)2.62735158
80positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.62726488
81auditory behavior (GO:0031223)2.61956271
82protein-cofactor linkage (GO:0018065)2.60551938
83pseudouridine synthesis (GO:0001522)2.59497299
84behavioral fear response (GO:0001662)2.58635379
85behavioral defense response (GO:0002209)2.58635379
86regulation of meiosis I (GO:0060631)2.58549254
87protein localization to endoplasmic reticulum (GO:0070972)2.58019775
88protein targeting to vacuole (GO:0006623)2.57129946
89protein targeting to lysosome (GO:0006622)2.57129946
90establishment of protein localization to vacuole (GO:0072666)2.57129946
91indole-containing compound metabolic process (GO:0042430)2.56143157
92axoneme assembly (GO:0035082)2.55611321
93positive regulation of smooth muscle contraction (GO:0045987)2.55314476
94ribosomal small subunit biogenesis (GO:0042274)2.53139984
95regulation of sensory perception (GO:0051931)2.53026335
96regulation of sensory perception of pain (GO:0051930)2.53026335
97negative regulation of cytosolic calcium ion concentration (GO:0051481)2.53017635
98cell proliferation in forebrain (GO:0021846)2.52679297
99striatum development (GO:0021756)2.52476853
100translational elongation (GO:0006414)2.50769213

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.80237933
2* ZNF274_21170338_ChIP-Seq_K562_Hela3.29443896
3GBX2_23144817_ChIP-Seq_PC3_Human3.28631718
4VDR_22108803_ChIP-Seq_LS180_Human3.25245645
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.92979053
6IRF1_19129219_ChIP-ChIP_H3396_Human2.72106632
7CBX2_27304074_Chip-Seq_ESCs_Mouse2.58286495
8RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.48677245
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.38051858
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.34466246
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.21683107
12FUS_26573619_Chip-Seq_HEK293_Human2.17974893
13MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human2.16448570
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.10060214
15TAF15_26573619_Chip-Seq_HEK293_Human2.02701185
16CTBP1_25329375_ChIP-Seq_LNCAP_Human2.01178996
17PIAS1_25552417_ChIP-Seq_VCAP_Human2.01047654
18CTBP2_25329375_ChIP-Seq_LNCAP_Human1.96730112
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.94952498
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.93599924
21GABP_17652178_ChIP-ChIP_JURKAT_Human1.92999687
22EWS_26573619_Chip-Seq_HEK293_Human1.87803483
23CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.80230222
24IGF1R_20145208_ChIP-Seq_DFB_Human1.74706182
25POU3F2_20337985_ChIP-ChIP_501MEL_Human1.71095901
26MYC_18940864_ChIP-ChIP_HL60_Human1.68245302
27ELK1_19687146_ChIP-ChIP_HELA_Human1.67664232
28SALL1_21062744_ChIP-ChIP_HESCs_Human1.66543563
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.66265375
30P300_19829295_ChIP-Seq_ESCs_Human1.65768246
31LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65517193
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.63402006
33CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.61317945
34BCAT_22108803_ChIP-Seq_LS180_Human1.60589345
35KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.59591995
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.57971086
37IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.55092113
38CBP_20019798_ChIP-Seq_JUKART_Human1.55092113
39AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.53757990
40TP63_19390658_ChIP-ChIP_HaCaT_Human1.50161886
41EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.48774242
42ER_23166858_ChIP-Seq_MCF-7_Human1.44806047
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44402621
44EZH2_27304074_Chip-Seq_ESCs_Mouse1.43207197
45SUZ12_27294783_Chip-Seq_NPCs_Mouse1.41711669
46ETV2_25802403_ChIP-Seq_MESCs_Mouse1.40906208
47TP53_22573176_ChIP-Seq_HFKS_Human1.40463796
48PCGF2_27294783_Chip-Seq_NPCs_Mouse1.39329583
49NOTCH1_21737748_ChIP-Seq_TLL_Human1.39039676
50UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.38235105
51REST_21632747_ChIP-Seq_MESCs_Mouse1.37757919
52BMI1_23680149_ChIP-Seq_NPCS_Mouse1.36550339
53POU5F1_16153702_ChIP-ChIP_HESCs_Human1.35251741
54ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.34087105
55SMAD4_21799915_ChIP-Seq_A2780_Human1.33479907
56TCF4_23295773_ChIP-Seq_U87_Human1.33475144
57MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.32842308
58NR3C1_21868756_ChIP-Seq_MCF10A_Human1.30427865
59SMAD3_21741376_ChIP-Seq_EPCs_Human1.30321491
60STAT3_23295773_ChIP-Seq_U87_Human1.29889644
61SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28001903
62RBPJ_22232070_ChIP-Seq_NCS_Mouse1.26359851
63TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26159325
64CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26010339
65EED_16625203_ChIP-ChIP_MESCs_Mouse1.20393548
66NFE2_27457419_Chip-Seq_LIVER_Mouse1.19860031
67SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.18320086
68SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.18309673
69SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.17476022
70EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15785134
71SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13647029
72FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.13615678
73REST_18959480_ChIP-ChIP_MESCs_Mouse1.13332094
74P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12383312
75JARID2_20064375_ChIP-Seq_MESCs_Mouse1.12249386
76AR_25329375_ChIP-Seq_VCAP_Human1.09590893
77KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.09400647
78EST1_17652178_ChIP-ChIP_JURKAT_Human1.08960540
79OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08630478
80RNF2_27304074_Chip-Seq_NSC_Mouse1.08529551
81SMAD4_21741376_ChIP-Seq_EPCs_Human1.08324018
82SUZ12_27294783_Chip-Seq_ESCs_Mouse1.07915816
83SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.07844199
84NANOG_18555785_Chip-Seq_ESCs_Mouse1.05945451
85TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04769017
86JARID2_20075857_ChIP-Seq_MESCs_Mouse1.03553507
87TCF4_22108803_ChIP-Seq_LS180_Human1.03391968
88PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.03342764
89RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.02086341
90RUNX2_22187159_ChIP-Seq_PCA_Human1.01977025
91GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01483825
92P53_22387025_ChIP-Seq_ESCs_Mouse1.01227107
93AR_20517297_ChIP-Seq_VCAP_Human1.01155396
94MYC_19829295_ChIP-Seq_ESCs_Human1.01114754
95AUTS2_25519132_ChIP-Seq_293T-REX_Human1.00586035
96SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.00359609
97EZH2_27294783_Chip-Seq_ESCs_Mouse0.98162482
98NCOR_22424771_ChIP-Seq_293T_Human0.98087832
99SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.97637832
100TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.97376034

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy3.88915769
2MP0001188_hyperpigmentation3.48981754
3MP0002638_abnormal_pupillary_reflex3.26784199
4MP0006292_abnormal_olfactory_placode2.61148536
5MP0010030_abnormal_orbit_morphology2.42342883
6MP0005646_abnormal_pituitary_gland2.25609075
7MP0002102_abnormal_ear_morphology2.14967894
8MP0005084_abnormal_gallbladder_morpholo2.13142539
9MP0004885_abnormal_endolymph2.13028441
10MP0005187_abnormal_penis_morphology2.11288134
11MP0005248_abnormal_Harderian_gland1.99943407
12MP0005551_abnormal_eye_electrophysiolog1.95072010
13MP0001529_abnormal_vocalization1.85866787
14MP0001984_abnormal_olfaction1.78346712
15MP0006276_abnormal_autonomic_nervous1.77482857
16MP0009384_cardiac_valve_regurgitation1.72567018
17MP0001486_abnormal_startle_reflex1.72469824
18MP0009745_abnormal_behavioral_response1.69405467
19MP0000049_abnormal_middle_ear1.67848943
20MP0001501_abnormal_sleep_pattern1.67738005
21MP0002138_abnormal_hepatobiliary_system1.65450165
22MP0001502_abnormal_circadian_rhythm1.64192810
23MP0009053_abnormal_anal_canal1.63570571
24MP0008877_abnormal_DNA_methylation1.63202843
25MP0002736_abnormal_nociception_after1.60831522
26MP0001879_abnormal_lymphatic_vessel1.60236506
27MP0006072_abnormal_retinal_apoptosis1.59219543
28MP0002653_abnormal_ependyma_morphology1.57610356
29MP0000631_abnormal_neuroendocrine_gland1.57359787
30MP0003787_abnormal_imprinting1.55356245
31MP0008789_abnormal_olfactory_epithelium1.54819661
32MP0002272_abnormal_nervous_system1.52260632
33MP0003195_calcinosis1.51538528
34MP0000026_abnormal_inner_ear1.49484945
35MP0004133_heterotaxia1.48942477
36MP0002837_dystrophic_cardiac_calcinosis1.45163272
37MP0002752_abnormal_somatic_nervous1.44986009
38MP0000778_abnormal_nervous_system1.44466263
39MP0005195_abnormal_posterior_eye1.44350842
40MP0000647_abnormal_sebaceous_gland1.43526951
41MP0005499_abnormal_olfactory_system1.42664384
42MP0005394_taste/olfaction_phenotype1.42664384
43MP0003937_abnormal_limbs/digits/tail_de1.40096874
44MP0003880_abnormal_central_pattern1.37976635
45MP0001968_abnormal_touch/_nociception1.35273221
46MP0001286_abnormal_eye_development1.34809520
47MP0008775_abnormal_heart_ventricle1.32006461
48MP0002938_white_spotting1.29327520
49MP0002132_abnormal_respiratory_system1.29113945
50MP0002067_abnormal_sensory_capabilities1.26709901
51MP0002184_abnormal_innervation1.26118729
52MP0002064_seizures1.25722465
53MP0001324_abnormal_eye_pigmentation1.24232969
54MP0003119_abnormal_digestive_system1.22687500
55MP0002572_abnormal_emotion/affect_behav1.22660050
56MP0000537_abnormal_urethra_morphology1.22581336
57MP0002751_abnormal_autonomic_nervous1.21414906
58MP0002557_abnormal_social/conspecific_i1.19671230
59MP0005253_abnormal_eye_physiology1.17603703
60MP0003942_abnormal_urinary_system1.17094134
61MP0002733_abnormal_thermal_nociception1.13650995
62MP0002063_abnormal_learning/memory/cond1.12557754
63MP0001963_abnormal_hearing_physiology1.12170317
64MP0001293_anophthalmia1.11859987
65MP0000230_abnormal_systemic_arterial1.09394914
66MP0004924_abnormal_behavior1.05757118
67MP0005386_behavior/neurological_phenoty1.05757118
68MP0002882_abnormal_neuron_morphology1.04591992
69MP0003635_abnormal_synaptic_transmissio1.04451117
70MP0004742_abnormal_vestibular_system1.02556073
71MP0000462_abnormal_digestive_system1.01708202
72MP0009379_abnormal_foot_pigmentation1.01181825
73MP0003122_maternal_imprinting0.99581263
74MP0000383_abnormal_hair_follicle0.98436043
75MP0003136_yellow_coat_color0.96322730
76MP0004142_abnormal_muscle_tone0.96295507
77MP0002928_abnormal_bile_duct0.95907277
78MP0001919_abnormal_reproductive_system0.94108383
79MP0009046_muscle_twitch0.91893784
80MP0004145_abnormal_muscle_electrophysio0.91373141
81MP0002735_abnormal_chemical_nociception0.91252162
82MP0005423_abnormal_somatic_nervous0.91220497
83MP0003011_delayed_dark_adaptation0.89474445
84MP0004085_abnormal_heartbeat0.88870169
85MP0003186_abnormal_redox_activity0.87043474
86MP0002233_abnormal_nose_morphology0.86416574
87MP0003698_abnormal_male_reproductive0.85722749
88MP0000955_abnormal_spinal_cord0.85303216
89MP0001905_abnormal_dopamine_level0.85085253
90MP0001270_distended_abdomen0.84223583
91MP0001970_abnormal_pain_threshold0.80660908
92MP0002152_abnormal_brain_morphology0.79515463
93MP0003861_abnormal_nervous_system0.79331232
94MP0005645_abnormal_hypothalamus_physiol0.78759271
95MP0005389_reproductive_system_phenotype0.78658821
96MP0002095_abnormal_skin_pigmentation0.78386031
97MP0002876_abnormal_thyroid_physiology0.78057214
98MP0000613_abnormal_salivary_gland0.77127979
99MP0005391_vision/eye_phenotype0.74440777
100MP0002909_abnormal_adrenal_gland0.72098177

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)5.85627472
2Pigmentary retinal degeneration (HP:0001146)4.00350852
3Chorioretinal atrophy (HP:0000533)3.99387002
4Pendular nystagmus (HP:0012043)3.88190514
5Type II lissencephaly (HP:0007260)3.81432563
6Pancreatic fibrosis (HP:0100732)3.41318087
7Decreased electroretinogram (ERG) amplitude (HP:0000654)3.36578067
8Abnormality of midbrain morphology (HP:0002418)3.18886664
9Molar tooth sign on MRI (HP:0002419)3.18886664
10Abnormality of the labia minora (HP:0012880)3.01961781
11Medial flaring of the eyebrow (HP:0010747)2.97748991
12Cerebellar dysplasia (HP:0007033)2.97634897
13Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.94969431
14Abnormality of alanine metabolism (HP:0010916)2.94969431
15Hyperalaninemia (HP:0003348)2.94969431
16Retinal dysplasia (HP:0007973)2.92351715
17Lissencephaly (HP:0001339)2.82256837
18Hypoplasia of the pons (HP:0012110)2.82242086
19Nephrogenic diabetes insipidus (HP:0009806)2.73222191
20Abnormality of cells of the erythroid lineage (HP:0012130)2.69672348
21Pancreatic cysts (HP:0001737)2.65540794
22Global brain atrophy (HP:0002283)2.65222840
23Gait imbalance (HP:0002141)2.56298605
24Symphalangism affecting the phalanges of the hand (HP:0009773)2.55426196
25Abnormal drinking behavior (HP:0030082)2.51745439
26Polydipsia (HP:0001959)2.51745439
27Ectopic kidney (HP:0000086)2.51551152
28Congenital primary aphakia (HP:0007707)2.50596039
29Abnormality of the pons (HP:0007361)2.50022773
30Abnormal number of erythroid precursors (HP:0012131)2.48854982
31Rib fusion (HP:0000902)2.45921171
32Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.44804861
33Absent rod-and cone-mediated responses on ERG (HP:0007688)2.32639951
34Septo-optic dysplasia (HP:0100842)2.31183461
35Abnormality of the parathyroid morphology (HP:0011766)2.26408931
36Anencephaly (HP:0002323)2.22193091
37Limb dystonia (HP:0002451)2.21455979
38Humeroradial synostosis (HP:0003041)2.20053926
39Synostosis involving the elbow (HP:0003938)2.20053926
40Decreased central vision (HP:0007663)2.19376231
41Oligodactyly (hands) (HP:0001180)2.17422628
42Genital tract atresia (HP:0001827)2.16651276
43Aplasia/Hypoplasia of the tibia (HP:0005772)2.15898214
44Abnormal rod and cone electroretinograms (HP:0008323)2.14919600
45Vaginal atresia (HP:0000148)2.13752398
46Type I diabetes mellitus (HP:0100651)2.12321594
47Polyuria (HP:0000103)2.12187446
48True hermaphroditism (HP:0010459)2.11457998
49Nephronophthisis (HP:0000090)2.09266914
50Hepatocellular necrosis (HP:0001404)2.06831961
51Optic nerve hypoplasia (HP:0000609)2.05600833
52Cutaneous finger syndactyly (HP:0010554)2.04534613
53Abnormality of the 4th metacarpal (HP:0010012)2.01474839
54Chronic hepatic failure (HP:0100626)2.00128026
55Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.98598686
56Reticulocytopenia (HP:0001896)1.97540683
57Abnormality of the pubic bones (HP:0003172)1.97513036
58Abnormality of the phalanges of the 5th finger (HP:0004213)1.97181641
59Hepatoblastoma (HP:0002884)1.96535662
60Short tibia (HP:0005736)1.90924121
61Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.90846269
62Tubular atrophy (HP:0000092)1.89913035
63Aplasia/Hypoplasia of the uvula (HP:0010293)1.89273957
64Stenosis of the external auditory canal (HP:0000402)1.86883578
65Hyperglycinemia (HP:0002154)1.84425894
66Macrocytic anemia (HP:0001972)1.82092356
67Abolished electroretinogram (ERG) (HP:0000550)1.81339050
68Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.81251245
69Short 1st metacarpal (HP:0010034)1.81251245
70Agitation (HP:0000713)1.79544769
71Focal motor seizures (HP:0011153)1.79274558
72Aplasia/Hypoplasia of the patella (HP:0006498)1.78725355
73Abnormality of the renal cortex (HP:0011035)1.78498260
74Abnormal urine output (HP:0012590)1.76848092
75Attenuation of retinal blood vessels (HP:0007843)1.75352401
76Esophageal atresia (HP:0002032)1.74939042
77Abnormality of DNA repair (HP:0003254)1.74863826
78Poor coordination (HP:0002370)1.74760709
79Congenital sensorineural hearing impairment (HP:0008527)1.73315791
80Mitochondrial inheritance (HP:0001427)1.73143328
81Patellar aplasia (HP:0006443)1.72668077
82Pheochromocytoma (HP:0002666)1.71826265
83Adactyly (HP:0009776)1.71577085
84Keratoconus (HP:0000563)1.70932456
85Increased corneal curvature (HP:0100692)1.70932456
86Sclerocornea (HP:0000647)1.70760926
87Drooling (HP:0002307)1.70535850
88Hepatic necrosis (HP:0002605)1.68910717
89Abnormality of the renal medulla (HP:0100957)1.68594957
90Abnormal ciliary motility (HP:0012262)1.67500010
91Hemivertebrae (HP:0002937)1.66337154
92Cutaneous syndactyly (HP:0012725)1.64723624
93Dyskinesia (HP:0100660)1.64543328
94Occipital encephalocele (HP:0002085)1.61869912
95Abnormality of the anterior horn cell (HP:0006802)1.61390061
96Degeneration of anterior horn cells (HP:0002398)1.61390061
97Hypophosphatemic rickets (HP:0004912)1.61158774
98Lipid accumulation in hepatocytes (HP:0006561)1.59313175
99Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.59125255
100Short phalanx of the thumb (HP:0009660)1.59010668

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PIK3CA4.36891407
2ADRBK23.44590141
3FRK3.16908810
4BCKDK2.68282236
5GRK12.66830460
6MAP3K92.51736599
7TAOK32.46908879
8NUAK12.32349224
9STK392.20266619
10MAPK132.14646858
11PINK12.13363037
12MAP3K42.12658987
13MAP2K72.09084285
14NTRK22.03692243
15PRKD31.98190577
16EPHB21.97519679
17CASK1.82910153
18TLK11.65998887
19EPHA31.65843907
20MAP4K21.59330755
21WNK41.57715130
22WNK31.50930629
23TIE11.47177456
24MARK11.46964953
25PASK1.46200275
26MAP3K131.37697399
27ADRBK11.37453601
28DYRK31.32208664
29CSNK1G31.31001927
30PLK21.25392030
31CSNK1G11.25118188
32CSNK1G21.23701793
33PRKCG1.15328678
34RPS6KA51.11628110
35CSNK1A1L1.09354199
36INSRR1.08885995
37DYRK21.07715453
38DYRK1B1.01703769
39MST41.00301173
40PAK30.99307245
41STK240.97968660
42PRKCE0.96462098
43VRK10.94362069
44BRSK20.93112651
45DYRK1A0.90233966
46BMPR1B0.88935620
47RPS6KA40.88853994
48EPHA40.88477446
49PLK40.85446019
50TGFBR10.82989208
51PTK60.82359659
52CAMKK20.78927313
53TNIK0.76286632
54OXSR10.74822012
55BCR0.73703584
56STK38L0.72668372
57PTK2B0.70846701
58IRAK10.69868218
59CAMK2B0.66969854
60MAP2K20.66856369
61PRKCI0.66481269
62NLK0.66056349
63NTRK30.63283675
64CAMK2A0.62187770
65DAPK20.61085845
66MAPK150.58962607
67PRKCQ0.58033286
68SGK20.55763244
69ACVR1B0.52818587
70CLK10.51064671
71ARAF0.50472349
72PRKACA0.50260166
73CAMK2D0.49326655
74DMPK0.48181329
75CSNK1A10.48090744
76ERBB20.45198978
77SGK4940.44273777
78SGK2230.44273777
79CSNK1D0.44030410
80FGFR10.43618559
81CAMK2G0.42670923
82TXK0.42387553
83PRKD20.41154857
84CDK50.41034780
85GRK70.38563550
86MAP2K40.38295926
87RAF10.38161130
88WEE10.37692646
89PRKG10.36820994
90STK30.36204894
91ABL20.34671995
92PKN10.32559832
93PLK10.31928920
94ZAK0.31735364
95PHKG20.30863573
96PHKG10.30863573
97PRKCH0.30743343
98MOS0.30396056
99BRD40.30176771
100KSR10.29009124

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006034.46081190
2Phototransduction_Homo sapiens_hsa047443.43370877
3Ribosome_Homo sapiens_hsa030103.16143931
4Protein export_Homo sapiens_hsa030602.66826174
5Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.49132716
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.46706903
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.35666305
8Selenocompound metabolism_Homo sapiens_hsa004502.29071267
9Tryptophan metabolism_Homo sapiens_hsa003802.15738333
10Butanoate metabolism_Homo sapiens_hsa006502.15385057
11Oxidative phosphorylation_Homo sapiens_hsa001902.08061299
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.05967227
13Taste transduction_Homo sapiens_hsa047422.00175329
14Nicotine addiction_Homo sapiens_hsa050331.93036210
15Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.92652845
16Linoleic acid metabolism_Homo sapiens_hsa005911.86852449
17Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.85674762
18RNA polymerase_Homo sapiens_hsa030201.83681874
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.81579789
20Parkinsons disease_Homo sapiens_hsa050121.70206324
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.70196702
22Propanoate metabolism_Homo sapiens_hsa006401.69253599
23Cardiac muscle contraction_Homo sapiens_hsa042601.68372795
24alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.58443215
25Fanconi anemia pathway_Homo sapiens_hsa034601.49149721
26Nitrogen metabolism_Homo sapiens_hsa009101.37777890
27Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.37373597
28Ether lipid metabolism_Homo sapiens_hsa005651.36448332
29Basal transcription factors_Homo sapiens_hsa030221.35185764
30Olfactory transduction_Homo sapiens_hsa047401.34820718
31Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.25098981
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.23683764
33Huntingtons disease_Homo sapiens_hsa050161.20718617
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.15227012
35Serotonergic synapse_Homo sapiens_hsa047261.13181279
36Dorso-ventral axis formation_Homo sapiens_hsa043201.08832781
37Hedgehog signaling pathway_Homo sapiens_hsa043401.08248307
38Homologous recombination_Homo sapiens_hsa034401.07362964
39Basal cell carcinoma_Homo sapiens_hsa052171.05973433
40Alzheimers disease_Homo sapiens_hsa050101.01853507
41RNA degradation_Homo sapiens_hsa030181.01058682
42Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.94637555
43Cocaine addiction_Homo sapiens_hsa050300.91453984
44Insulin secretion_Homo sapiens_hsa049110.89146696
45Folate biosynthesis_Homo sapiens_hsa007900.88653546
46p53 signaling pathway_Homo sapiens_hsa041150.88181852
47Cysteine and methionine metabolism_Homo sapiens_hsa002700.83915402
48RNA transport_Homo sapiens_hsa030130.83254435
49Sulfur metabolism_Homo sapiens_hsa009200.83137291
50Morphine addiction_Homo sapiens_hsa050320.82879308
51GABAergic synapse_Homo sapiens_hsa047270.79470983
52Axon guidance_Homo sapiens_hsa043600.78554570
53Caffeine metabolism_Homo sapiens_hsa002320.77812066
54Purine metabolism_Homo sapiens_hsa002300.76886690
55Maturity onset diabetes of the young_Homo sapiens_hsa049500.74292625
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.71550037
57beta-Alanine metabolism_Homo sapiens_hsa004100.71360404
58Calcium signaling pathway_Homo sapiens_hsa040200.70488600
59Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.70335803
60Circadian entrainment_Homo sapiens_hsa047130.70138385
61Circadian rhythm_Homo sapiens_hsa047100.66435550
62Nucleotide excision repair_Homo sapiens_hsa034200.65586741
63Fat digestion and absorption_Homo sapiens_hsa049750.64906615
64Peroxisome_Homo sapiens_hsa041460.64510999
65Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.62379283
66Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.62154664
67Retinol metabolism_Homo sapiens_hsa008300.61262941
68Chemical carcinogenesis_Homo sapiens_hsa052040.61091261
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.61054912
70Arachidonic acid metabolism_Homo sapiens_hsa005900.59415916
71Fatty acid biosynthesis_Homo sapiens_hsa000610.57806118
72Metabolic pathways_Homo sapiens_hsa011000.51470171
73Proteasome_Homo sapiens_hsa030500.50442700
74Tyrosine metabolism_Homo sapiens_hsa003500.49984384
75Fatty acid degradation_Homo sapiens_hsa000710.49767834
76Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.49194645
77Glycerolipid metabolism_Homo sapiens_hsa005610.48511898
78Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.46462219
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45910590
80Phenylalanine metabolism_Homo sapiens_hsa003600.45739898
81Oxytocin signaling pathway_Homo sapiens_hsa049210.45584863
82Hippo signaling pathway_Homo sapiens_hsa043900.45110106
83Glutamatergic synapse_Homo sapiens_hsa047240.43345983
84Mismatch repair_Homo sapiens_hsa034300.43073144
85Dopaminergic synapse_Homo sapiens_hsa047280.42918976
86Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42772805
87Amphetamine addiction_Homo sapiens_hsa050310.41288359
88Cholinergic synapse_Homo sapiens_hsa047250.41022010
89Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.40685141
90ABC transporters_Homo sapiens_hsa020100.39018799
91Salivary secretion_Homo sapiens_hsa049700.38515298
92Vascular smooth muscle contraction_Homo sapiens_hsa042700.37546540
93Synaptic vesicle cycle_Homo sapiens_hsa047210.35748994
94Pyrimidine metabolism_Homo sapiens_hsa002400.35403281
95Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.33183987
96Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33048198
97Long-term depression_Homo sapiens_hsa047300.32891308
98Gastric acid secretion_Homo sapiens_hsa049710.32444676
99Regulation of autophagy_Homo sapiens_hsa041400.31869145
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30803198

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